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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DMWD-LIMS1 (FusionGDB2 ID:HG1762TG3987)

Fusion Gene Summary for DMWD-LIMS1

check button Fusion gene summary
Fusion gene informationFusion gene name: DMWD-LIMS1
Fusion gene ID: hg1762tg3987
HgeneTgene
Gene symbol

DMWD

LIMS1

Gene ID

1762

3987

Gene nameDM1 locus, WD repeat containingLIM zinc finger domain containing 1
SynonymsD19S593E|DMR-N9|DMRN9|gene59PINCH|PINCH-1|PINCH1
Cytomap('DMWD')('LIMS1')

19q13.32

2q12.3

Type of geneprotein-codingprotein-coding
Descriptiondystrophia myotonica WD repeat-containing proteindystrophia myotonica, WD repeat containingdystrophia myotonica-containing WD repeat motif proteinprotein 59LIM and senescent cell antigen-like-containing domain protein 1LIM and senescent cell antigen-like domains 1LIM-type zinc finger domains 1particularly interesting new Cys-His protein 1renal carcinoma antigen NY-REN-48senescent cell antigen
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000270223, ENST00000377735, 
ENST00000601370, 
Fusion gene scores* DoF score6 X 3 X 6=1082 X 2 X 2=8
# samples 82
** MAII scorelog2(8/108*10)=-0.432959407276106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: DMWD [Title/Abstract] AND LIMS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDMWD(46294163)-LIMS1(109300341), # samples:1
Anticipated loss of major functional domain due to fusion event.DMWD-LIMS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DMWD-LIMS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLIMS1

GO:0045892

negative regulation of transcription, DNA-templated

21390327


check buttonFusion gene breakpoints across DMWD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across LIMS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-5721-01ADMWDchr19

46294163

-LIMS1chr2

109300341

+


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Fusion Gene ORF analysis for DMWD-LIMS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000270223ENST00000393314DMWDchr19

46294163

-LIMS1chr2

109300341

+
5CDS-intronENST00000270223ENST00000462817DMWDchr19

46294163

-LIMS1chr2

109300341

+
5CDS-intronENST00000270223ENST00000542845DMWDchr19

46294163

-LIMS1chr2

109300341

+
5CDS-intronENST00000377735ENST00000393314DMWDchr19

46294163

-LIMS1chr2

109300341

+
5CDS-intronENST00000377735ENST00000462817DMWDchr19

46294163

-LIMS1chr2

109300341

+
5CDS-intronENST00000377735ENST00000542845DMWDchr19

46294163

-LIMS1chr2

109300341

+
5UTR-3CDSENST00000601370ENST00000332345DMWDchr19

46294163

-LIMS1chr2

109300341

+
5UTR-3CDSENST00000601370ENST00000338045DMWDchr19

46294163

-LIMS1chr2

109300341

+
5UTR-3CDSENST00000601370ENST00000393310DMWDchr19

46294163

-LIMS1chr2

109300341

+
5UTR-3CDSENST00000601370ENST00000409441DMWDchr19

46294163

-LIMS1chr2

109300341

+
5UTR-3CDSENST00000601370ENST00000410093DMWDchr19

46294163

-LIMS1chr2

109300341

+
5UTR-3CDSENST00000601370ENST00000544547DMWDchr19

46294163

-LIMS1chr2

109300341

+
5UTR-intronENST00000601370ENST00000393314DMWDchr19

46294163

-LIMS1chr2

109300341

+
5UTR-intronENST00000601370ENST00000462817DMWDchr19

46294163

-LIMS1chr2

109300341

+
5UTR-intronENST00000601370ENST00000542845DMWDchr19

46294163

-LIMS1chr2

109300341

+
Frame-shiftENST00000270223ENST00000338045DMWDchr19

46294163

-LIMS1chr2

109300341

+
Frame-shiftENST00000270223ENST00000393310DMWDchr19

46294163

-LIMS1chr2

109300341

+
Frame-shiftENST00000270223ENST00000409441DMWDchr19

46294163

-LIMS1chr2

109300341

+
Frame-shiftENST00000270223ENST00000410093DMWDchr19

46294163

-LIMS1chr2

109300341

+
Frame-shiftENST00000377735ENST00000338045DMWDchr19

46294163

-LIMS1chr2

109300341

+
Frame-shiftENST00000377735ENST00000393310DMWDchr19

46294163

-LIMS1chr2

109300341

+
Frame-shiftENST00000377735ENST00000409441DMWDchr19

46294163

-LIMS1chr2

109300341

+
Frame-shiftENST00000377735ENST00000410093DMWDchr19

46294163

-LIMS1chr2

109300341

+
In-frameENST00000270223ENST00000332345DMWDchr19

46294163

-LIMS1chr2

109300341

+
In-frameENST00000270223ENST00000544547DMWDchr19

46294163

-LIMS1chr2

109300341

+
In-frameENST00000377735ENST00000332345DMWDchr19

46294163

-LIMS1chr2

109300341

+
In-frameENST00000377735ENST00000544547DMWDchr19

46294163

-LIMS1chr2

109300341

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000377735DMWDchr1946294163-ENST00000544547LIMS1chr2109300341+137667046675209
ENST00000377735DMWDchr1946294163-ENST00000332345LIMS1chr2109300341+92367046675209
ENST00000270223DMWDchr1946294163-ENST00000544547LIMS1chr2109300341+137667046675209
ENST00000270223DMWDchr1946294163-ENST00000332345LIMS1chr2109300341+92367046675209

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377735ENST00000544547DMWDchr1946294163-LIMS1chr2109300341+0.0067497070.99325037
ENST00000377735ENST00000332345DMWDchr1946294163-LIMS1chr2109300341+0.034741220.9652587
ENST00000270223ENST00000544547DMWDchr1946294163-LIMS1chr2109300341+0.0067497070.99325037
ENST00000270223ENST00000332345DMWDchr1946294163-LIMS1chr2109300341+0.034741220.9652587

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Fusion Genomic Features for DMWD-LIMS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DMWDchr1946294162-LIMS1chr2109300340+2.04E-070.99999976
DMWDchr1946294162-LIMS1chr2109300340+2.04E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DMWD-LIMS1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:46294163/chr2:109300341)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDMWDchr19:46294163chr2:109300341ENST00000270223-25157_202208675.0RepeatNote=WD 2
HgeneDMWDchr19:46294163chr2:109300341ENST00000270223-2586_156208675.0RepeatNote=WD 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDMWDchr19:46294163chr2:109300341ENST00000270223-25203_274208675.0RepeatNote=WD 3
HgeneDMWDchr19:46294163chr2:109300341ENST00000270223-25275_316208675.0RepeatNote=WD 4
HgeneDMWDchr19:46294163chr2:109300341ENST00000270223-25317_394208675.0RepeatNote=WD 5
HgeneDMWDchr19:46294163chr2:109300341ENST00000270223-25395_444208675.0RepeatNote=WD 6
TgeneLIMS1chr19:46294163chr2:109300341ENST0000033234581010_62287326.0DomainLIM zinc-binding 1
TgeneLIMS1chr19:46294163chr2:109300341ENST00000332345810135_184287326.0DomainLIM zinc-binding 3
TgeneLIMS1chr19:46294163chr2:109300341ENST00000332345810193_243287326.0DomainLIM zinc-binding 4
TgeneLIMS1chr19:46294163chr2:109300341ENST00000332345810252_303287326.0DomainLIM zinc-binding 5
TgeneLIMS1chr19:46294163chr2:109300341ENST0000033234581071_121287326.0DomainLIM zinc-binding 2
TgeneLIMS1chr19:46294163chr2:109300341ENST0000033804581010_62287326.0DomainLIM zinc-binding 1
TgeneLIMS1chr19:46294163chr2:109300341ENST00000338045810135_184287326.0DomainLIM zinc-binding 3
TgeneLIMS1chr19:46294163chr2:109300341ENST00000338045810193_243287326.0DomainLIM zinc-binding 4
TgeneLIMS1chr19:46294163chr2:109300341ENST00000338045810252_303287326.0DomainLIM zinc-binding 5
TgeneLIMS1chr19:46294163chr2:109300341ENST0000033804581071_121287326.0DomainLIM zinc-binding 2
TgeneLIMS1chr19:46294163chr2:109300341ENST0000039331081010_62287326.0DomainLIM zinc-binding 1
TgeneLIMS1chr19:46294163chr2:109300341ENST00000393310810135_184287326.0DomainLIM zinc-binding 3
TgeneLIMS1chr19:46294163chr2:109300341ENST00000393310810193_243287326.0DomainLIM zinc-binding 4
TgeneLIMS1chr19:46294163chr2:109300341ENST00000393310810252_303287326.0DomainLIM zinc-binding 5
TgeneLIMS1chr19:46294163chr2:109300341ENST0000039331081071_121287326.0DomainLIM zinc-binding 2
TgeneLIMS1chr19:46294163chr2:109300341ENST0000040944181010_62324363.0DomainLIM zinc-binding 1
TgeneLIMS1chr19:46294163chr2:109300341ENST00000409441810135_184324363.0DomainLIM zinc-binding 3
TgeneLIMS1chr19:46294163chr2:109300341ENST00000409441810193_243324363.0DomainLIM zinc-binding 4
TgeneLIMS1chr19:46294163chr2:109300341ENST00000409441810252_303324363.0DomainLIM zinc-binding 5
TgeneLIMS1chr19:46294163chr2:109300341ENST0000040944181071_121324363.0DomainLIM zinc-binding 2
TgeneLIMS1chr19:46294163chr2:109300341ENST0000041009381010_62291330.0DomainLIM zinc-binding 1
TgeneLIMS1chr19:46294163chr2:109300341ENST00000410093810135_184291330.0DomainLIM zinc-binding 3
TgeneLIMS1chr19:46294163chr2:109300341ENST00000410093810193_243291330.0DomainLIM zinc-binding 4
TgeneLIMS1chr19:46294163chr2:109300341ENST00000410093810252_303291330.0DomainLIM zinc-binding 5
TgeneLIMS1chr19:46294163chr2:109300341ENST0000041009381071_121291330.0DomainLIM zinc-binding 2
TgeneLIMS1chr19:46294163chr2:109300341ENST0000054284581010_62349388.0DomainLIM zinc-binding 1
TgeneLIMS1chr19:46294163chr2:109300341ENST00000542845810135_184349388.0DomainLIM zinc-binding 3
TgeneLIMS1chr19:46294163chr2:109300341ENST00000542845810193_243349388.0DomainLIM zinc-binding 4
TgeneLIMS1chr19:46294163chr2:109300341ENST00000542845810252_303349388.0DomainLIM zinc-binding 5
TgeneLIMS1chr19:46294163chr2:109300341ENST0000054284581071_121349388.0DomainLIM zinc-binding 2
TgeneLIMS1chr19:46294163chr2:109300341ENST0000054454781010_62299338.0DomainLIM zinc-binding 1
TgeneLIMS1chr19:46294163chr2:109300341ENST00000544547810135_184299338.0DomainLIM zinc-binding 3
TgeneLIMS1chr19:46294163chr2:109300341ENST00000544547810193_243299338.0DomainLIM zinc-binding 4
TgeneLIMS1chr19:46294163chr2:109300341ENST00000544547810252_303299338.0DomainLIM zinc-binding 5
TgeneLIMS1chr19:46294163chr2:109300341ENST0000054454781071_121299338.0DomainLIM zinc-binding 2


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Fusion Gene Sequence for DMWD-LIMS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23273_23273_1_DMWD-LIMS1_DMWD_chr19_46294163_ENST00000270223_LIMS1_chr2_109300341_ENST00000332345_length(transcript)=923nt_BP=670nt
CTGCGGGCGGCAGTCCGGCAGTGGCGGGGCCCGGGGGGCGCCCAAGATGGCGGCGGGCGGCGCGGAGGGCGGCTCGGGCCCCGGCGCCGC
CATGGGGGACTGCGCGGAGATTAAGTCGCAATTCCGCACGCGCGAGGGTTTCTACAAGCTACTCCCGGGCGACGGCGCCGCTCGCAGGTC
GGGTCCGGCTTCCGCCCAGACTCCGGTGCCGCCTCAGCCACCGCAGCCCCCGCCCGGCCCTGCCTCCGCCTCCGGTCCCGGCGCTGCAGG
CCCCGCGTCGTCCCCGCCGCCCGCAGGCCCCGGACCCGGGCCCGCCCTGCCCGCCGTGCGCCTCAGCCTCGTGCGCCTCGGGGAGCCGGA
CAGCGCCGGGGCCGGGGAGCCGCCCGCCACGCCCGCGGGGCTGGGCTCGGGGGGAGACCGCGTCTGCTTCAACTTGGGCCGTGAGCTCTA
TTTCTACCCAGGCTGCTGTCGTCGTGGGAGCCAACGGTCCATTGACCTCAACAAGCCAATTGACAAGCGGATCTACAAGGGCACCCAGCC
CACCTGCCACGATTTCAACCAGTTCACTGCTGCCACCGAGACCATCTCGCTGCTGGTGGGCTTCTCAGCGGGTCAAGTGCAGTACCTGGA
TCTCATCAAAAAGGACACCAGCAAGCTGTTCAATGAGGAGGAATAAGTTTGTGGAGTTTGACATGAAGCCAGTCTGTAAGAAGTGCTATG
AGAAATTTCCATTGGAGCTGAAGAAAAGACTTAAGAAACTAGCTGAGACCTTAGGAAGGAAATAAGTTCCTTTATTTTTTCTTTTCTATG
CAAGATAAGAGATTACCAACATTACTTGTCTTGATCTACCCATATTTAAAGCTATATCTCAAAGCAGTTGAGAGAAGAGGACCTATATGA

>23273_23273_1_DMWD-LIMS1_DMWD_chr19_46294163_ENST00000270223_LIMS1_chr2_109300341_ENST00000332345_length(amino acids)=209AA_BP=
MAAGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSPPPAGPGPGPA
LPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDRVCFNLGRELYFYPGCCRRGSQRSIDLNKPIDKRIYKGTQPTCHDFNQFTAATETI

--------------------------------------------------------------
>23273_23273_2_DMWD-LIMS1_DMWD_chr19_46294163_ENST00000270223_LIMS1_chr2_109300341_ENST00000544547_length(transcript)=1376nt_BP=670nt
CTGCGGGCGGCAGTCCGGCAGTGGCGGGGCCCGGGGGGCGCCCAAGATGGCGGCGGGCGGCGCGGAGGGCGGCTCGGGCCCCGGCGCCGC
CATGGGGGACTGCGCGGAGATTAAGTCGCAATTCCGCACGCGCGAGGGTTTCTACAAGCTACTCCCGGGCGACGGCGCCGCTCGCAGGTC
GGGTCCGGCTTCCGCCCAGACTCCGGTGCCGCCTCAGCCACCGCAGCCCCCGCCCGGCCCTGCCTCCGCCTCCGGTCCCGGCGCTGCAGG
CCCCGCGTCGTCCCCGCCGCCCGCAGGCCCCGGACCCGGGCCCGCCCTGCCCGCCGTGCGCCTCAGCCTCGTGCGCCTCGGGGAGCCGGA
CAGCGCCGGGGCCGGGGAGCCGCCCGCCACGCCCGCGGGGCTGGGCTCGGGGGGAGACCGCGTCTGCTTCAACTTGGGCCGTGAGCTCTA
TTTCTACCCAGGCTGCTGTCGTCGTGGGAGCCAACGGTCCATTGACCTCAACAAGCCAATTGACAAGCGGATCTACAAGGGCACCCAGCC
CACCTGCCACGATTTCAACCAGTTCACTGCTGCCACCGAGACCATCTCGCTGCTGGTGGGCTTCTCAGCGGGTCAAGTGCAGTACCTGGA
TCTCATCAAAAAGGACACCAGCAAGCTGTTCAATGAGGAGGAATAAGTTTGTGGAGTTTGACATGAAGCCAGTCTGTAAGAAGTGCTATG
AGAAATTTCCATTGGAGCTGAAGAAAAGACTTAAGAAACTAGCTGAGACCTTAGGAAGGAAATAAGTTCCTTTATTTTTTCTTTTCTATG
CAAGATAAGAGATTACCAACATTACTTGTCTTGATCTACCCATATTTAAAGCTATATCTCAAAGCAGTTGAGAGAAGAGGACCTATATGA
ATGGTTTTATGTCATTTTTTTAATTAAAAAAGAAAAATTCATATAATCGTGTTTAAAACACAAATGAAGTCAGTATTTGCCTTTGTTAAC
CCTTATCCATTTGTTGACATGTAGACTGTTTACAAAAAAAAAACACATGGTTAAATGTTAAATTTTAATTAAGGCCCCCAAAAATTAAAT
ATAACTTTTTAAAATGAAAGGAGTCACCTTTTACATGACTCAGGTGAAAAAACAGTATAAACATTAATTTACTTTGTGTTCAAAAGAAAA
TTCCAACTGCTGTTGGGGAAGGACACAGAAAAGAAAAATAACCACCCAAGAAAAACAAAAACAAGAAAAACAAATCTTATACAATCTTAG
TATATTTATCAAACTAGTAGCTAGAAAGTGAATATGCACATTACTAAGACAAAAAACAAGTGTAATTCAGAACTACTTGATTTTTTTTAG

>23273_23273_2_DMWD-LIMS1_DMWD_chr19_46294163_ENST00000270223_LIMS1_chr2_109300341_ENST00000544547_length(amino acids)=209AA_BP=
MAAGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSPPPAGPGPGPA
LPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDRVCFNLGRELYFYPGCCRRGSQRSIDLNKPIDKRIYKGTQPTCHDFNQFTAATETI

--------------------------------------------------------------
>23273_23273_3_DMWD-LIMS1_DMWD_chr19_46294163_ENST00000377735_LIMS1_chr2_109300341_ENST00000332345_length(transcript)=923nt_BP=670nt
CTGCGGGCGGCAGTCCGGCAGTGGCGGGGCCCGGGGGGCGCCCAAGATGGCGGCGGGCGGCGCGGAGGGCGGCTCGGGCCCCGGCGCCGC
CATGGGGGACTGCGCGGAGATTAAGTCGCAATTCCGCACGCGCGAGGGTTTCTACAAGCTACTCCCGGGCGACGGCGCCGCTCGCAGGTC
GGGTCCGGCTTCCGCCCAGACTCCGGTGCCGCCTCAGCCACCGCAGCCCCCGCCCGGCCCTGCCTCCGCCTCCGGTCCCGGCGCTGCAGG
CCCCGCGTCGTCCCCGCCGCCCGCAGGCCCCGGACCCGGGCCCGCCCTGCCCGCCGTGCGCCTCAGCCTCGTGCGCCTCGGGGAGCCGGA
CAGCGCCGGGGCCGGGGAGCCGCCCGCCACGCCCGCGGGGCTGGGCTCGGGGGGAGACCGCGTCTGCTTCAACTTGGGCCGTGAGCTCTA
TTTCTACCCAGGCTGCTGTCGTCGTGGGAGCCAACGGTCCATTGACCTCAACAAGCCAATTGACAAGCGGATCTACAAGGGCACCCAGCC
CACCTGCCACGATTTCAACCAGTTCACTGCTGCCACCGAGACCATCTCGCTGCTGGTGGGCTTCTCAGCGGGTCAAGTGCAGTACCTGGA
TCTCATCAAAAAGGACACCAGCAAGCTGTTCAATGAGGAGGAATAAGTTTGTGGAGTTTGACATGAAGCCAGTCTGTAAGAAGTGCTATG
AGAAATTTCCATTGGAGCTGAAGAAAAGACTTAAGAAACTAGCTGAGACCTTAGGAAGGAAATAAGTTCCTTTATTTTTTCTTTTCTATG
CAAGATAAGAGATTACCAACATTACTTGTCTTGATCTACCCATATTTAAAGCTATATCTCAAAGCAGTTGAGAGAAGAGGACCTATATGA

>23273_23273_3_DMWD-LIMS1_DMWD_chr19_46294163_ENST00000377735_LIMS1_chr2_109300341_ENST00000332345_length(amino acids)=209AA_BP=
MAAGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSPPPAGPGPGPA
LPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDRVCFNLGRELYFYPGCCRRGSQRSIDLNKPIDKRIYKGTQPTCHDFNQFTAATETI

--------------------------------------------------------------
>23273_23273_4_DMWD-LIMS1_DMWD_chr19_46294163_ENST00000377735_LIMS1_chr2_109300341_ENST00000544547_length(transcript)=1376nt_BP=670nt
CTGCGGGCGGCAGTCCGGCAGTGGCGGGGCCCGGGGGGCGCCCAAGATGGCGGCGGGCGGCGCGGAGGGCGGCTCGGGCCCCGGCGCCGC
CATGGGGGACTGCGCGGAGATTAAGTCGCAATTCCGCACGCGCGAGGGTTTCTACAAGCTACTCCCGGGCGACGGCGCCGCTCGCAGGTC
GGGTCCGGCTTCCGCCCAGACTCCGGTGCCGCCTCAGCCACCGCAGCCCCCGCCCGGCCCTGCCTCCGCCTCCGGTCCCGGCGCTGCAGG
CCCCGCGTCGTCCCCGCCGCCCGCAGGCCCCGGACCCGGGCCCGCCCTGCCCGCCGTGCGCCTCAGCCTCGTGCGCCTCGGGGAGCCGGA
CAGCGCCGGGGCCGGGGAGCCGCCCGCCACGCCCGCGGGGCTGGGCTCGGGGGGAGACCGCGTCTGCTTCAACTTGGGCCGTGAGCTCTA
TTTCTACCCAGGCTGCTGTCGTCGTGGGAGCCAACGGTCCATTGACCTCAACAAGCCAATTGACAAGCGGATCTACAAGGGCACCCAGCC
CACCTGCCACGATTTCAACCAGTTCACTGCTGCCACCGAGACCATCTCGCTGCTGGTGGGCTTCTCAGCGGGTCAAGTGCAGTACCTGGA
TCTCATCAAAAAGGACACCAGCAAGCTGTTCAATGAGGAGGAATAAGTTTGTGGAGTTTGACATGAAGCCAGTCTGTAAGAAGTGCTATG
AGAAATTTCCATTGGAGCTGAAGAAAAGACTTAAGAAACTAGCTGAGACCTTAGGAAGGAAATAAGTTCCTTTATTTTTTCTTTTCTATG
CAAGATAAGAGATTACCAACATTACTTGTCTTGATCTACCCATATTTAAAGCTATATCTCAAAGCAGTTGAGAGAAGAGGACCTATATGA
ATGGTTTTATGTCATTTTTTTAATTAAAAAAGAAAAATTCATATAATCGTGTTTAAAACACAAATGAAGTCAGTATTTGCCTTTGTTAAC
CCTTATCCATTTGTTGACATGTAGACTGTTTACAAAAAAAAAACACATGGTTAAATGTTAAATTTTAATTAAGGCCCCCAAAAATTAAAT
ATAACTTTTTAAAATGAAAGGAGTCACCTTTTACATGACTCAGGTGAAAAAACAGTATAAACATTAATTTACTTTGTGTTCAAAAGAAAA
TTCCAACTGCTGTTGGGGAAGGACACAGAAAAGAAAAATAACCACCCAAGAAAAACAAAAACAAGAAAAACAAATCTTATACAATCTTAG
TATATTTATCAAACTAGTAGCTAGAAAGTGAATATGCACATTACTAAGACAAAAAACAAGTGTAATTCAGAACTACTTGATTTTTTTTAG

>23273_23273_4_DMWD-LIMS1_DMWD_chr19_46294163_ENST00000377735_LIMS1_chr2_109300341_ENST00000544547_length(amino acids)=209AA_BP=
MAAGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSPPPAGPGPGPA
LPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDRVCFNLGRELYFYPGCCRRGSQRSIDLNKPIDKRIYKGTQPTCHDFNQFTAATETI

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Fusion Gene PPI Analysis for DMWD-LIMS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DMWD-LIMS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DMWD-LIMS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource