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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DYNC1I1-ASB4 (FusionGDB2 ID:HG1780TG51666)

Fusion Gene Summary for DYNC1I1-ASB4

Fusion gene summary

Fusion gene information	Fusion gene name: DYNC1I1-ASB4
	Fusion gene ID: hg1780tg51666
		Hgene	Tgene
	Gene symbol	DYNC1I1	ASB4
	Gene ID	1780	51666
	Gene name	dynein cytoplasmic 1 intermediate chain 1	ankyrin repeat and SOCS box containing 4
	Synonyms	DNCI1\|DNCIC1	ASB-4
	Cytomap	('DYNC1I1')('ASB4') 7q21.3	7q21.3
	Type of gene	protein-coding	protein-coding
	Description	cytoplasmic dynein 1 intermediate chain 1DH IC-1cytoplasmic dynein intermediate chain 1dynein intermediate chain 1, cytosolicdynein, cytoplasmic, intermediate polypeptide 1	ankyrin repeat and SOCS box protein 4
	Modification date	20200313	20200313
	UniProtAcc	.	Q9Y574
	Ensembl transtripts involved in fusion gene	ENST00000324972, ENST00000359388, ENST00000437599, ENST00000447467, ENST00000457059, ENST00000537881, ENST00000413338, ENST00000497626,	ENST00000324972, ENST00000359388, ENST00000413338, ENST00000437599, ENST00000447467, ENST00000457059, ENST00000537881, ENST00000497626,
Fusion gene scores	* DoF score	6 X 5 X 6=180	3 X 3 X 3=27
	# samples	7	3
	** MAII score	log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: DYNC1I1 [Title/Abstract] AND ASB4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DYNC1I1(95499310)-ASB4(95125070), # samples:3
Anticipated loss of major functional domain due to fusion event.	DYNC1I1-ASB4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DYNC1I1-ASB4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DYNC1I1-ASB4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DYNC1I1-ASB4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DYNC1I1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ASB4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ACC	TCGA-OR-A5J1-01A	DYNC1I1	chr7	95499310	-	ASB4	chr7	95125070	+
ChimerDB4	ACC	TCGA-OR-A5J1-01A	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+

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Fusion Gene ORF analysis for DYNC1I1-ASB4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000324972	ENST00000257621	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
5CDS-3UTR	ENST00000324972	ENST00000428113	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
5CDS-3UTR	ENST00000359388	ENST00000257621	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
5CDS-3UTR	ENST00000359388	ENST00000428113	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
5CDS-3UTR	ENST00000437599	ENST00000257621	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
5CDS-3UTR	ENST00000437599	ENST00000428113	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
5CDS-3UTR	ENST00000447467	ENST00000257621	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
5CDS-3UTR	ENST00000447467	ENST00000428113	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
5CDS-3UTR	ENST00000457059	ENST00000257621	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
5CDS-3UTR	ENST00000457059	ENST00000428113	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
5CDS-3UTR	ENST00000537881	ENST00000257621	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
5CDS-3UTR	ENST00000537881	ENST00000428113	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
In-frame	ENST00000324972	ENST00000325885	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
In-frame	ENST00000359388	ENST00000325885	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
In-frame	ENST00000437599	ENST00000325885	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
In-frame	ENST00000447467	ENST00000325885	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
In-frame	ENST00000457059	ENST00000325885	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
In-frame	ENST00000537881	ENST00000325885	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
intron-3CDS	ENST00000413338	ENST00000325885	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
intron-3CDS	ENST00000497626	ENST00000325885	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
intron-3UTR	ENST00000413338	ENST00000257621	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
intron-3UTR	ENST00000413338	ENST00000428113	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
intron-3UTR	ENST00000497626	ENST00000257621	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+
intron-3UTR	ENST00000497626	ENST00000428113	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000447467	DYNC1I1	chr7	95499310	+	ENST00000325885	ASB4	chr7	95125070	+	4286	719	154	1812	552
ENST00000324972	DYNC1I1	chr7	95499310	+	ENST00000325885	ASB4	chr7	95125070	+	4301	734	118	1827	569
ENST00000537881	DYNC1I1	chr7	95499310	+	ENST00000325885	ASB4	chr7	95125070	+	4186	619	114	1712	532
ENST00000437599	DYNC1I1	chr7	95499310	+	ENST00000325885	ASB4	chr7	95125070	+	4234	667	111	1760	549
ENST00000359388	DYNC1I1	chr7	95499310	+	ENST00000325885	ASB4	chr7	95125070	+	4182	615	110	1708	532
ENST00000457059	DYNC1I1	chr7	95499310	+	ENST00000325885	ASB4	chr7	95125070	+	4157	590	73	1683	536

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000447467	ENST00000325885	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+	0.000655939	0.99934405
ENST00000324972	ENST00000325885	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+	0.000510701	0.9994893
ENST00000537881	ENST00000325885	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+	0.000485065	0.99951494
ENST00000437599	ENST00000325885	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+	0.000442644	0.9995573
ENST00000359388	ENST00000325885	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+	0.000480774	0.9995192
ENST00000457059	ENST00000325885	DYNC1I1	chr7	95499310	+	ASB4	chr7	95125070	+	0.000754831	0.99924517

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Fusion Genomic Features for DYNC1I1-ASB4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
DYNC1I1	chr7	95499310	+	ASB4	chr7	95125069	+	0.056653623	0.94334644
DYNC1I1	chr7	95499310	+	ASB4	chr7	95125069	+	0.056653623	0.94334644

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DYNC1I1-ASB4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:95499310/chr7:95125070)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ASB4 Q9Y574
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ASB4

chr7:95499310

chr7:95125070

ENST00000325885

371_423

427.0

Domain

SOCS box

Tgene

ASB4

chr7:95499310

chr7:95125070

ENST00000428113

371_423

350.0

Domain

SOCS box

Tgene

ASB4

chr7:95499310

chr7:95125070

ENST00000325885

106_135

427.0

Repeat

Note=ANK 2

Tgene

ASB4

chr7:95499310

chr7:95125070

ENST00000325885

139_168

427.0

Repeat

Note=ANK 3

Tgene

ASB4

chr7:95499310

chr7:95125070

ENST00000325885

174_203

427.0

Repeat

Note=ANK 4

Tgene

ASB4

chr7:95499310

chr7:95125070

ENST00000325885

207_247

427.0

Repeat

Note=ANK 5

Tgene

ASB4

chr7:95499310

chr7:95125070

ENST00000325885

251_280

427.0

Repeat

Note=ANK 6

Tgene

ASB4

chr7:95499310

chr7:95125070

ENST00000325885

74_103

427.0

Repeat

Note=ANK 1

Tgene

ASB4

chr7:95499310

chr7:95125070

ENST00000428113

106_135

350.0

Repeat

Note=ANK 2

Tgene

ASB4

chr7:95499310

chr7:95125070

ENST00000428113

139_168

350.0

Repeat

Note=ANK 3

Tgene

ASB4

chr7:95499310

chr7:95125070

ENST00000428113

174_203

350.0

Repeat

Note=ANK 4

Tgene

ASB4

chr7:95499310

chr7:95125070

ENST00000428113

207_247

350.0

Repeat

Note=ANK 5

Tgene

ASB4

chr7:95499310

chr7:95125070

ENST00000428113

251_280

350.0

Repeat

Note=ANK 6

Tgene

ASB4

chr7:95499310

chr7:95125070

ENST00000428113

74_103

350.0

Repeat

Note=ANK 1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000324972

285_334

180

646.0

Repeat

Note=WD 1

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000324972

338_378

180

646.0

Repeat

Note=WD 2

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000324972

387_428

180

646.0

Repeat

Note=WD 3

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000324972

437_477

180

646.0

Repeat

Note=WD 4

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000324972

482_527

180

646.0

Repeat

Note=WD 5

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000324972

530_570

180

646.0

Repeat

Note=WD 6

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000324972

576_615

180

646.0

Repeat

Note=WD 7

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000359388

285_334

143

609.0

Repeat

Note=WD 1

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000359388

338_378

143

609.0

Repeat

Note=WD 2

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000359388

387_428

143

609.0

Repeat

Note=WD 3

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000359388

437_477

143

609.0

Repeat

Note=WD 4

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000359388

482_527

143

609.0

Repeat

Note=WD 5

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000359388

530_570

143

609.0

Repeat

Note=WD 6

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000359388

576_615

143

609.0

Repeat

Note=WD 7

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000447467

285_334

163

629.0

Repeat

Note=WD 1

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000447467

338_378

163

629.0

Repeat

Note=WD 2

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000447467

387_428

163

629.0

Repeat

Note=WD 3

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000447467

437_477

163

629.0

Repeat

Note=WD 4

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000447467

482_527

163

629.0

Repeat

Note=WD 5

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000447467

530_570

163

629.0

Repeat

Note=WD 6

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000447467

576_615

163

629.0

Repeat

Note=WD 7

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000457059

285_334

163

629.0

Repeat

Note=WD 1

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000457059

338_378

163

629.0

Repeat

Note=WD 2

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000457059

387_428

163

629.0

Repeat

Note=WD 3

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000457059

437_477

163

629.0

Repeat

Note=WD 4

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000457059

482_527

163

629.0

Repeat

Note=WD 5

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000457059

530_570

163

629.0

Repeat

Note=WD 6

Hgene

DYNC1I1

chr7:95499310

chr7:95125070

ENST00000457059

576_615

163

629.0

Repeat

Note=WD 7

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Fusion Gene Sequence for DYNC1I1-ASB4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>24610_24610_1_DYNC1I1-ASB4_DYNC1I1_chr7_95499310_ENST00000324972_ASB4_chr7_95125070_ENST00000325885_length(transcript)=4301nt_BP=734nt
CTGGGAGAGAGGAAGTGATCGCTCCCGGAGGAGCGCGAGCCGAGCGGCCGGCGCAGCGTGAGACAGCACATCCTGCCCGCGCCGGCCCCG
CCACCTTCGGGAGCCGCCTGCACCAACGCTGCCGCCGCCCAGGAGCCGCCGCCGGCTCGGGGAGCCCAGTTCCGCCGCTGCCGAGCGCGT
CCAGGAAACCAACATGTCTGACAAAAGTGACTTAAAAGCTGAGCTAGAGCGCAAAAAGCAGCGCTTAGCACAGATAAGAGAAGAGAAGAA
ACGGAAGGAAGAGGAGAGGAAAAAGAAAGAGGCTGATATGCAGCAGAAGAAAGAACCCGTTCAGGACGACTCTGATCTGGATCGCAAACG
ACGAGAGACAGAGGCTTTGCTGCAAAGCATTGGTATCTCACCGGAGCCGCCTCTAGTGCAGCCGCTGCATTTTTTAACATGGGATACCTG
TTATTTTCATTATTTAGTCCCAACCCCTATGTCTCCCTCCTCGAAATCAGTGAGCACTCCCAGTGAAGCTGGAAGCCAAGACTCAGGCGA
TCTGGGGCCATTAACAAGGACCCTGCAGTGGGACACAGACCCCTCAGTGCTCCAGCTGCAGTCAGACTCAGAACTTGGAAGAAGACTGCA
TAAACTGGGCGTGTCAAAGGTCACCCAAGTGGATTTCCTGCCAAGGGAAGTAGTGTCCTACTCAAAGGAGACCCAGACTCCTCTTGCCAC
GCATCAGTCTGAAGGTTACTGGTTGCCTAGCTATAAATTGAAGTCTTCCTGGGCCACAGGCCTCCATCTCTCTGTCTTGTTTGGCCATGT
GGAATGTCTTCTGGTGCTACTGGACCACAATGCTACAATCAACTGTAGACCCAATGGGAAAACCCCTCTTCACGTGGCTTGTGAAATGGC
CAATGTGGATTGTGTTAAGATCCTCTGTGATCGTGGGGCAAAGCTCAATTGCTACTCCTTAAGTGGACACACAGCTTTGCACTTTTGTAC
AACTCCAAGTTCCATTCTCTGTGCCAAGCAATTGGTTTGGAGAGGGGCGAATGTGAACATGAAGACCAACAACCAAGATGAGGAGACGCC
CTTGCACACGGCTGCCCACTTCGGCCTTTCGGAGCTGGTGGCCTTCTACGTGGAACACGGGGCCATAGTGGACAGCGTGAATGCCCACAT
GGAGACCCCCCTGGCCATCGCCGCCTACTGGGCCCTCCGCTTTAAGGAGCAGGAGTACAGCACGGAGCACCACCTGGTCTGCCGCATGCT
GCTTGACTACAAAGCCGAAGTCAATGCCCGAGATGACGACTTTAAATCTCCCCTCCACAAGGCAGCCTGGAACTGTGACCACGTGCTCAT
GCACATGATGCTGGAAGCTGGCGCCGAAGCCAATCTCATGGATATCAACGGCTGTGCTGCCATCCAGTACGTGCTGAAGGTCACCTCCGT
GCGCCCTGCTGCCCAGCCTGAGATCTGCTACCAGCTCCTGTTGAACCATGGGGCTGCCCGAATATACCCTCCACAGTTCCATAAGGTGAT
ACAGGCCTGCCATTCTTGTCCTAAAGCAATTGAAGTTGTAGTCAATGCCTATGAACACATCAGATGGAACACAAAGTGGAGAAGAGCTAT
CCCCGATGATGACTTGGAGAAATACTGGGATTTTTACCACTCTCTCTTTACTGTGTGCTGTAACTCTCCAAGGACTCTCATGCACTTATC
GAGATGTGCCATTAGAAGAACATTACACAACAGATGCCATAGAGCAATTCCTTTGCTTTCCCTCCCATTGTCATTGAAAAAGTACTTGCT
TTTAGAGCCAGAGGGAATTATTTATTAAGCCTTATGAGACAGCAGTTCCCAATCCTAGGTATTTAAGTGGACTTGCTGGGTAGACACAGT
TTGCCTAAATAAAATGGTACTTGGGTTGATTATAACACTTCAGGGATTTCAAAACACTTTACAAACACTGCCATTAATCCTAGAATATCA
TGGTATGGGGAAATAAAGAAGAAGTAAAGTTAAGGAATTTTCAAAGACAAGGATGTATTCAGAATGTACTGATAGAACAGTAATAACTAA
TATGTATAGTGTTCTTACTAAGTACCTGAAATATTTTTGTAAAACTTCTTATATCTTATCTCATCTGAAATGGGACCCAGGTTTTCTTCC
AACCAATATAATTCTGTGCCTTATCAGTAATATGTTTACATTCTCATTCAAATGGCCATATAGCAGGCTTTGCAATTGGCCTCTTAAACT
TGGTGTTTTCCCCCATTACCCCTTAGCAGTAATTACTGTCACTAGTTTTGCAAACTCCTACTCCCCAAACCAAGCTACTCAAGTTTATTT
CAGTGATGAAGGCATATGAGCATAGTCAAAACAAGGAGATCTTGGAGTCAAATTAGAAATGAGAAAGAAACATCAGTCCAGTTAATAGTC
AAGAATGGACATTTGAACCAGACATCACTGAGCCAGAGACTGGAGATGCAAAGATGAGTCCCATGTGACTCCTGCCTTCCAGGATCTCAC
CATTTAGCAGAGGATCCAGACATACACACAGCTAACTGCAATATAAAGTGATGGGGCAAGAGTACAGGTGCAGACTCACTTTTAATGCTT
ATCTTTCAAAGTTGTGTTTCTGACATGAAGTGTGATTTTTCTTTTAAGCATGAAGTTAAAGAGTGAAGGGGTTATGTAAAGTAGAGGGAT
CTCCTGCTCTTGTTAGGGTATTTTTAAGGTTTTTTCTAGATAGTGTGTCTTTTTGGTATGGTTTCTTGGTTAGTATTAATACTTTCCCAG
ACTCCTTGAGAAAAATATTGCACACTCAATGGCTCCAGTGCATGTGACAAGGAAGCATAGGAAAATGGGGGAAAGAAAGTGTGTGAGGGG
ACCTAGTTGATTACTTCGGTCTTTTTATGTAGCAGACTGACATTTCATAGCATTGTAGCTAAGAGATAAGGAGCACTTTGCTAGTGACAG
TGGGCTACGAAAAGTAAATAGAGAGACTTTTTGAAAATGGTAAAAGTTTGAGAAACTTGGGAAGATTAGTGTGTTAATCAGGCTTGCTAG
TTAGTGGATTGCAGAAAGAAAAATGTAGGTGATTAAGCTCTGGGCCTTGTGGTTTATGAGGTCAATTTTGCTTCACTTTTTTTTTTGTTC
TTGCTATAATCACTTTTAGATAAGCTCATTGCTCTTAGCATCATTTTTTAGAGGTTAAAGCAGAAGTAAATTGCAAACAAATCTGTCAGT
TGTGAGCAGATTTCTTTTATGTGTGTGGTTCTCCATCATATTTAACTTTGGATGCTGGAGTGTTGAATAGAGATGATGTCAGATATTCCA
ATAGGCTATCATTTAATGTTAACTGGCAATCACCTAACTGGTTAATCTCAGTTGAGACTGTGCTTCTGAACTGGGATTGTCTTACTCCCA
GGGCTGTGTAAGAAAAGTCATAGGTGGATACAATAATCTCTTTTAAGTATCAGTTTTACTCAGATATTTTGGTGGAGATATTTTGTACTA
AAACAAGATCTATATCATGGAATAGAATGCTGAATTTGTATGAATTATTCACATAAAGCTTGATCTTTCAAAAAATAGTTTGCTTGCAGC
AAGTGGTATTAGAACACATCCTAAAACAGAATGAAATGATGTCTTTTGCAGCAACTTGGATGGAGCTGGAGGCCATTATTCTAAGTGAAG
TAACTCAGGAATGGAAAGTGAAATACCATATGTTCTCACTTATAAGTGGGAGCTAAGCAATGAGGATGCAAAGACATCCAGAGTGATATA
ATGGACTATGGGGACTTGCAAGGGGAAGCTTGAGAGTGGGGTGAGGGATAAAAGACTACATATTGGGTACAGTGTACACTGCTCCAGTGA
TGGGTGCACTAAAATCTCAAAATTCACCACTAAAGAATGTATCCATGTAACCAAAAACCACCTGTACCCCCAAAACTATTGAAATCTTAA
AATAGTAATAATTAACAAAGTAAAACAAGATCACACCCTGGAACAATTGGAGGATTGCTTGCTGCCCTGCATCTTAAGGCGTATTCTAGC
AGCAAAGCTTGTGATGCACTGACTTGGGGCAAGTAAAACTGATGCTGAGGACAAAGGGAGAAGATGTTCCTCGCCCAGGGAAATGAAAAC
TTTTCTTATTCACCTTGCTTGTGCTTAAACACTTATGTTCATCTAGTGTAGAATACATGGCTACTTGTTTGTAATTTTTTTATTGGTGGA
ATTAAAGTAATTTTTCCTTATCTTTGAACTTTTATTTAGAGAACTTAAATAAAGCTCTTCTGTCTCCTTTC

>24610_24610_1_DYNC1I1-ASB4_DYNC1I1_chr7_95499310_ENST00000324972_ASB4_chr7_95125070_ENST00000325885_length(amino acids)=569AA_BP=205
MPPPRSRRRLGEPSSAAAERVQETNMSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQS
IGISPEPPLVQPLHFLTWDTCYFHYLVPTPMSPSSKSVSTPSEAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGRRLHKLGVSKVTQ
VDFLPREVVSYSKETQTPLATHQSEGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILC
DRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAY
WALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEIC
YQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPDDDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLH
NRCHRAIPLLSLPLSLKKYLLLEPEGIIY

--------------------------------------------------------------
>24610_24610_2_DYNC1I1-ASB4_DYNC1I1_chr7_95499310_ENST00000359388_ASB4_chr7_95125070_ENST00000325885_length(transcript)=4182nt_BP=615nt
GAGGAAGTGATCGCTCCCGGAGGAGCGCGAGCCGAGCGGCCGGCGCAGCGTGAGACAGCACATCCTGCCCGCGCCGGCCCCGCCACCTTC
GGGAGCCGCCTGCACCAACGCTGCCGCCGCCCAGGAGCCGCCGCCGGCTCGGGGAGCCCAGTTCCGCCGCTGCCGAGCGCGTCCAGGAAA
CCAACATGTCTGACAAAAGTGACTTAAAAGCTGAGCTAGAGCGCAAAAAGCAGCGCTTAGCACAGATAAGAGAAGAGAAGAAACGGAAGG
AAGAGGAGAGGAAAAAGAAAGAGGCTGATATGCAGCAGAAGAAAGAACCCGTTCAGGACGACTCTGATCTGGATCGCAAACGACGAGAGA
CAGAGGCTTTGCTGCAAAGCATTGGTATCTCACCGGAGCCGCCTCTAGTCCCAACCCCTATGTCTCCCTCCTCGAAATCAGTGAGCACTC
CCAGTGAAGCTGGAAGCCAAGACTCAGGCGATCTGGGGCCATTAACAAGAAGAAGACTGCATAAACTGGGCGTGTCAAAGGTCACCCAAG
TGGATTTCCTGCCAAGGGAAGTAGTGTCCTACTCAAAGGAGACCCAGACTCCTCTTGCCACGCATCAGTCTGAAGGTTACTGGTTGCCTA
GCTATAAATTGAAGTCTTCCTGGGCCACAGGCCTCCATCTCTCTGTCTTGTTTGGCCATGTGGAATGTCTTCTGGTGCTACTGGACCACA
ATGCTACAATCAACTGTAGACCCAATGGGAAAACCCCTCTTCACGTGGCTTGTGAAATGGCCAATGTGGATTGTGTTAAGATCCTCTGTG
ATCGTGGGGCAAAGCTCAATTGCTACTCCTTAAGTGGACACACAGCTTTGCACTTTTGTACAACTCCAAGTTCCATTCTCTGTGCCAAGC
AATTGGTTTGGAGAGGGGCGAATGTGAACATGAAGACCAACAACCAAGATGAGGAGACGCCCTTGCACACGGCTGCCCACTTCGGCCTTT
CGGAGCTGGTGGCCTTCTACGTGGAACACGGGGCCATAGTGGACAGCGTGAATGCCCACATGGAGACCCCCCTGGCCATCGCCGCCTACT
GGGCCCTCCGCTTTAAGGAGCAGGAGTACAGCACGGAGCACCACCTGGTCTGCCGCATGCTGCTTGACTACAAAGCCGAAGTCAATGCCC
GAGATGACGACTTTAAATCTCCCCTCCACAAGGCAGCCTGGAACTGTGACCACGTGCTCATGCACATGATGCTGGAAGCTGGCGCCGAAG
CCAATCTCATGGATATCAACGGCTGTGCTGCCATCCAGTACGTGCTGAAGGTCACCTCCGTGCGCCCTGCTGCCCAGCCTGAGATCTGCT
ACCAGCTCCTGTTGAACCATGGGGCTGCCCGAATATACCCTCCACAGTTCCATAAGGTGATACAGGCCTGCCATTCTTGTCCTAAAGCAA
TTGAAGTTGTAGTCAATGCCTATGAACACATCAGATGGAACACAAAGTGGAGAAGAGCTATCCCCGATGATGACTTGGAGAAATACTGGG
ATTTTTACCACTCTCTCTTTACTGTGTGCTGTAACTCTCCAAGGACTCTCATGCACTTATCGAGATGTGCCATTAGAAGAACATTACACA
ACAGATGCCATAGAGCAATTCCTTTGCTTTCCCTCCCATTGTCATTGAAAAAGTACTTGCTTTTAGAGCCAGAGGGAATTATTTATTAAG
CCTTATGAGACAGCAGTTCCCAATCCTAGGTATTTAAGTGGACTTGCTGGGTAGACACAGTTTGCCTAAATAAAATGGTACTTGGGTTGA
TTATAACACTTCAGGGATTTCAAAACACTTTACAAACACTGCCATTAATCCTAGAATATCATGGTATGGGGAAATAAAGAAGAAGTAAAG
TTAAGGAATTTTCAAAGACAAGGATGTATTCAGAATGTACTGATAGAACAGTAATAACTAATATGTATAGTGTTCTTACTAAGTACCTGA
AATATTTTTGTAAAACTTCTTATATCTTATCTCATCTGAAATGGGACCCAGGTTTTCTTCCAACCAATATAATTCTGTGCCTTATCAGTA
ATATGTTTACATTCTCATTCAAATGGCCATATAGCAGGCTTTGCAATTGGCCTCTTAAACTTGGTGTTTTCCCCCATTACCCCTTAGCAG
TAATTACTGTCACTAGTTTTGCAAACTCCTACTCCCCAAACCAAGCTACTCAAGTTTATTTCAGTGATGAAGGCATATGAGCATAGTCAA
AACAAGGAGATCTTGGAGTCAAATTAGAAATGAGAAAGAAACATCAGTCCAGTTAATAGTCAAGAATGGACATTTGAACCAGACATCACT
GAGCCAGAGACTGGAGATGCAAAGATGAGTCCCATGTGACTCCTGCCTTCCAGGATCTCACCATTTAGCAGAGGATCCAGACATACACAC
AGCTAACTGCAATATAAAGTGATGGGGCAAGAGTACAGGTGCAGACTCACTTTTAATGCTTATCTTTCAAAGTTGTGTTTCTGACATGAA
GTGTGATTTTTCTTTTAAGCATGAAGTTAAAGAGTGAAGGGGTTATGTAAAGTAGAGGGATCTCCTGCTCTTGTTAGGGTATTTTTAAGG
TTTTTTCTAGATAGTGTGTCTTTTTGGTATGGTTTCTTGGTTAGTATTAATACTTTCCCAGACTCCTTGAGAAAAATATTGCACACTCAA
TGGCTCCAGTGCATGTGACAAGGAAGCATAGGAAAATGGGGGAAAGAAAGTGTGTGAGGGGACCTAGTTGATTACTTCGGTCTTTTTATG
TAGCAGACTGACATTTCATAGCATTGTAGCTAAGAGATAAGGAGCACTTTGCTAGTGACAGTGGGCTACGAAAAGTAAATAGAGAGACTT
TTTGAAAATGGTAAAAGTTTGAGAAACTTGGGAAGATTAGTGTGTTAATCAGGCTTGCTAGTTAGTGGATTGCAGAAAGAAAAATGTAGG
TGATTAAGCTCTGGGCCTTGTGGTTTATGAGGTCAATTTTGCTTCACTTTTTTTTTTGTTCTTGCTATAATCACTTTTAGATAAGCTCAT
TGCTCTTAGCATCATTTTTTAGAGGTTAAAGCAGAAGTAAATTGCAAACAAATCTGTCAGTTGTGAGCAGATTTCTTTTATGTGTGTGGT
TCTCCATCATATTTAACTTTGGATGCTGGAGTGTTGAATAGAGATGATGTCAGATATTCCAATAGGCTATCATTTAATGTTAACTGGCAA
TCACCTAACTGGTTAATCTCAGTTGAGACTGTGCTTCTGAACTGGGATTGTCTTACTCCCAGGGCTGTGTAAGAAAAGTCATAGGTGGAT
ACAATAATCTCTTTTAAGTATCAGTTTTACTCAGATATTTTGGTGGAGATATTTTGTACTAAAACAAGATCTATATCATGGAATAGAATG
CTGAATTTGTATGAATTATTCACATAAAGCTTGATCTTTCAAAAAATAGTTTGCTTGCAGCAAGTGGTATTAGAACACATCCTAAAACAG
AATGAAATGATGTCTTTTGCAGCAACTTGGATGGAGCTGGAGGCCATTATTCTAAGTGAAGTAACTCAGGAATGGAAAGTGAAATACCAT
ATGTTCTCACTTATAAGTGGGAGCTAAGCAATGAGGATGCAAAGACATCCAGAGTGATATAATGGACTATGGGGACTTGCAAGGGGAAGC
TTGAGAGTGGGGTGAGGGATAAAAGACTACATATTGGGTACAGTGTACACTGCTCCAGTGATGGGTGCACTAAAATCTCAAAATTCACCA
CTAAAGAATGTATCCATGTAACCAAAAACCACCTGTACCCCCAAAACTATTGAAATCTTAAAATAGTAATAATTAACAAAGTAAAACAAG
ATCACACCCTGGAACAATTGGAGGATTGCTTGCTGCCCTGCATCTTAAGGCGTATTCTAGCAGCAAAGCTTGTGATGCACTGACTTGGGG
CAAGTAAAACTGATGCTGAGGACAAAGGGAGAAGATGTTCCTCGCCCAGGGAAATGAAAACTTTTCTTATTCACCTTGCTTGTGCTTAAA
CACTTATGTTCATCTAGTGTAGAATACATGGCTACTTGTTTGTAATTTTTTTATTGGTGGAATTAAAGTAATTTTTCCTTATCTTTGAAC
TTTTATTTAGAGAACTTAAATAAAGCTCTTCTGTCTCCTTTC

>24610_24610_2_DYNC1I1-ASB4_DYNC1I1_chr7_95499310_ENST00000359388_ASB4_chr7_95125070_ENST00000325885_length(amino acids)=532AA_BP=168
MPPPRSRRRLGEPSSAAAERVQETNMSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQS
IGISPEPPLVPTPMSPSSKSVSTPSEAGSQDSGDLGPLTRRRLHKLGVSKVTQVDFLPREVVSYSKETQTPLATHQSEGYWLPSYKLKSS
WATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGA
NVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKS
PLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNA
YEHIRWNTKWRRAIPDDDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLEPEGIIY

--------------------------------------------------------------
>24610_24610_3_DYNC1I1-ASB4_DYNC1I1_chr7_95499310_ENST00000437599_ASB4_chr7_95125070_ENST00000325885_length(transcript)=4234nt_BP=667nt
AGAGGAAGTGATCGCTCCCGGAGGAGCGCGAGCCGAGCGGCCGGCGCAGCGTGAGACAGCACATCCTGCCCGCGCCGGCCCCGCCACCTT
CGGGAGCCGCCTGCACCAACGCTGCCGCCGCCCAGGAGCCGCCGCCGGCTCGGGGAGCCCAGTTCCGCCGCTGCCGAGCGCGTCCAGGAA
ACCAACATGTCTGACAAAAGTGACTTAAAAGCTGAGCTAGAGCGCAAAAAGCAGCGCTTAGCACAGATAAGAGAAGAGAAGAAACGGAAG
GAAGAGGAGAGGAAAAAGAAAGAGGCTGATATGCAGCAGAAGAAAGAACCCGTTCAGGACGACTCTGATCTGGATCGCAAACGACGAGAG
ACAGAGGCTTTGCTGCAAAGCATTGGTATCTCACCGGAGCCGCCTCTAGTGCAGCCGCTGCATTTTTTAACATGGGATACCTGTTATTTT
CATTATTTAGTCCCAACCCCTATGTCTCCCTCCTCGAAATCAGTGAGCACTCCCAGTGAAGCTGGAAGCCAAGACTCAGGCGATCTGGGG
CCATTAACAAGAAGAAGACTGCATAAACTGGGCGTGTCAAAGGTCACCCAAGTGGATTTCCTGCCAAGGGAAGTAGTGTCCTACTCAAAG
GAGACCCAGACTCCTCTTGCCACGCATCAGTCTGAAGGTTACTGGTTGCCTAGCTATAAATTGAAGTCTTCCTGGGCCACAGGCCTCCAT
CTCTCTGTCTTGTTTGGCCATGTGGAATGTCTTCTGGTGCTACTGGACCACAATGCTACAATCAACTGTAGACCCAATGGGAAAACCCCT
CTTCACGTGGCTTGTGAAATGGCCAATGTGGATTGTGTTAAGATCCTCTGTGATCGTGGGGCAAAGCTCAATTGCTACTCCTTAAGTGGA
CACACAGCTTTGCACTTTTGTACAACTCCAAGTTCCATTCTCTGTGCCAAGCAATTGGTTTGGAGAGGGGCGAATGTGAACATGAAGACC
AACAACCAAGATGAGGAGACGCCCTTGCACACGGCTGCCCACTTCGGCCTTTCGGAGCTGGTGGCCTTCTACGTGGAACACGGGGCCATA
GTGGACAGCGTGAATGCCCACATGGAGACCCCCCTGGCCATCGCCGCCTACTGGGCCCTCCGCTTTAAGGAGCAGGAGTACAGCACGGAG
CACCACCTGGTCTGCCGCATGCTGCTTGACTACAAAGCCGAAGTCAATGCCCGAGATGACGACTTTAAATCTCCCCTCCACAAGGCAGCC
TGGAACTGTGACCACGTGCTCATGCACATGATGCTGGAAGCTGGCGCCGAAGCCAATCTCATGGATATCAACGGCTGTGCTGCCATCCAG
TACGTGCTGAAGGTCACCTCCGTGCGCCCTGCTGCCCAGCCTGAGATCTGCTACCAGCTCCTGTTGAACCATGGGGCTGCCCGAATATAC
CCTCCACAGTTCCATAAGGTGATACAGGCCTGCCATTCTTGTCCTAAAGCAATTGAAGTTGTAGTCAATGCCTATGAACACATCAGATGG
AACACAAAGTGGAGAAGAGCTATCCCCGATGATGACTTGGAGAAATACTGGGATTTTTACCACTCTCTCTTTACTGTGTGCTGTAACTCT
CCAAGGACTCTCATGCACTTATCGAGATGTGCCATTAGAAGAACATTACACAACAGATGCCATAGAGCAATTCCTTTGCTTTCCCTCCCA
TTGTCATTGAAAAAGTACTTGCTTTTAGAGCCAGAGGGAATTATTTATTAAGCCTTATGAGACAGCAGTTCCCAATCCTAGGTATTTAAG
TGGACTTGCTGGGTAGACACAGTTTGCCTAAATAAAATGGTACTTGGGTTGATTATAACACTTCAGGGATTTCAAAACACTTTACAAACA
CTGCCATTAATCCTAGAATATCATGGTATGGGGAAATAAAGAAGAAGTAAAGTTAAGGAATTTTCAAAGACAAGGATGTATTCAGAATGT
ACTGATAGAACAGTAATAACTAATATGTATAGTGTTCTTACTAAGTACCTGAAATATTTTTGTAAAACTTCTTATATCTTATCTCATCTG
AAATGGGACCCAGGTTTTCTTCCAACCAATATAATTCTGTGCCTTATCAGTAATATGTTTACATTCTCATTCAAATGGCCATATAGCAGG
CTTTGCAATTGGCCTCTTAAACTTGGTGTTTTCCCCCATTACCCCTTAGCAGTAATTACTGTCACTAGTTTTGCAAACTCCTACTCCCCA
AACCAAGCTACTCAAGTTTATTTCAGTGATGAAGGCATATGAGCATAGTCAAAACAAGGAGATCTTGGAGTCAAATTAGAAATGAGAAAG
AAACATCAGTCCAGTTAATAGTCAAGAATGGACATTTGAACCAGACATCACTGAGCCAGAGACTGGAGATGCAAAGATGAGTCCCATGTG
ACTCCTGCCTTCCAGGATCTCACCATTTAGCAGAGGATCCAGACATACACACAGCTAACTGCAATATAAAGTGATGGGGCAAGAGTACAG
GTGCAGACTCACTTTTAATGCTTATCTTTCAAAGTTGTGTTTCTGACATGAAGTGTGATTTTTCTTTTAAGCATGAAGTTAAAGAGTGAA
GGGGTTATGTAAAGTAGAGGGATCTCCTGCTCTTGTTAGGGTATTTTTAAGGTTTTTTCTAGATAGTGTGTCTTTTTGGTATGGTTTCTT
GGTTAGTATTAATACTTTCCCAGACTCCTTGAGAAAAATATTGCACACTCAATGGCTCCAGTGCATGTGACAAGGAAGCATAGGAAAATG
GGGGAAAGAAAGTGTGTGAGGGGACCTAGTTGATTACTTCGGTCTTTTTATGTAGCAGACTGACATTTCATAGCATTGTAGCTAAGAGAT
AAGGAGCACTTTGCTAGTGACAGTGGGCTACGAAAAGTAAATAGAGAGACTTTTTGAAAATGGTAAAAGTTTGAGAAACTTGGGAAGATT
AGTGTGTTAATCAGGCTTGCTAGTTAGTGGATTGCAGAAAGAAAAATGTAGGTGATTAAGCTCTGGGCCTTGTGGTTTATGAGGTCAATT
TTGCTTCACTTTTTTTTTTGTTCTTGCTATAATCACTTTTAGATAAGCTCATTGCTCTTAGCATCATTTTTTAGAGGTTAAAGCAGAAGT
AAATTGCAAACAAATCTGTCAGTTGTGAGCAGATTTCTTTTATGTGTGTGGTTCTCCATCATATTTAACTTTGGATGCTGGAGTGTTGAA
TAGAGATGATGTCAGATATTCCAATAGGCTATCATTTAATGTTAACTGGCAATCACCTAACTGGTTAATCTCAGTTGAGACTGTGCTTCT
GAACTGGGATTGTCTTACTCCCAGGGCTGTGTAAGAAAAGTCATAGGTGGATACAATAATCTCTTTTAAGTATCAGTTTTACTCAGATAT
TTTGGTGGAGATATTTTGTACTAAAACAAGATCTATATCATGGAATAGAATGCTGAATTTGTATGAATTATTCACATAAAGCTTGATCTT
TCAAAAAATAGTTTGCTTGCAGCAAGTGGTATTAGAACACATCCTAAAACAGAATGAAATGATGTCTTTTGCAGCAACTTGGATGGAGCT
GGAGGCCATTATTCTAAGTGAAGTAACTCAGGAATGGAAAGTGAAATACCATATGTTCTCACTTATAAGTGGGAGCTAAGCAATGAGGAT
GCAAAGACATCCAGAGTGATATAATGGACTATGGGGACTTGCAAGGGGAAGCTTGAGAGTGGGGTGAGGGATAAAAGACTACATATTGGG
TACAGTGTACACTGCTCCAGTGATGGGTGCACTAAAATCTCAAAATTCACCACTAAAGAATGTATCCATGTAACCAAAAACCACCTGTAC
CCCCAAAACTATTGAAATCTTAAAATAGTAATAATTAACAAAGTAAAACAAGATCACACCCTGGAACAATTGGAGGATTGCTTGCTGCCC
TGCATCTTAAGGCGTATTCTAGCAGCAAAGCTTGTGATGCACTGACTTGGGGCAAGTAAAACTGATGCTGAGGACAAAGGGAGAAGATGT
TCCTCGCCCAGGGAAATGAAAACTTTTCTTATTCACCTTGCTTGTGCTTAAACACTTATGTTCATCTAGTGTAGAATACATGGCTACTTG
TTTGTAATTTTTTTATTGGTGGAATTAAAGTAATTTTTCCTTATCTTTGAACTTTTATTTAGAGAACTTAAATAAAGCTCTTCTGTCTCC
TTTC

>24610_24610_3_DYNC1I1-ASB4_DYNC1I1_chr7_95499310_ENST00000437599_ASB4_chr7_95125070_ENST00000325885_length(amino acids)=549AA_BP=185
MPPPRSRRRLGEPSSAAAERVQETNMSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQS
IGISPEPPLVQPLHFLTWDTCYFHYLVPTPMSPSSKSVSTPSEAGSQDSGDLGPLTRRRLHKLGVSKVTQVDFLPREVVSYSKETQTPLA
THQSEGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFC
TTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRM
LLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKV
IQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPDDDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYL
LLEPEGIIY

--------------------------------------------------------------
>24610_24610_4_DYNC1I1-ASB4_DYNC1I1_chr7_95499310_ENST00000447467_ASB4_chr7_95125070_ENST00000325885_length(transcript)=4286nt_BP=719nt
AGACTGAGTGCTCCGGGGAGCTGTCAGTGTCAGGCTCTGGGAGAGAGGAAGTGATCGCTCCCGGAGGAGCGCGAGCCGAGCGGCCGGCGC
AGCGTGAGACAGCACATCCTGCCCGCGCCGGCCCCGCCACCTTCGGGAGCCGCCTGCACCAACGCTGCCGCCGCCCAGGAGCCGCCGCCG
GCTCGGGGAGCCCAGTTCCGCCGCTGCCGAGCGCGTCCAGGAAACCAACATGTCTGACAAAAGTGACTTAAAAGCTGAGCTAGAGCGCAA
AAAGCAGCGCTTAGCACAGATAAGAGAAGAGAAGAAACGGAAGGAAGAGGAGAGGAAAAAGAAAGAGGCTGATATGCAGCAGAAGAAAGA
ACCCGTTCAGGACGACTCTGATCTGGATCGCAAACGACGAGAGACAGAGGCTTTGCTGCAAAGCATTGGTATCTCACCGGAGCCGCCTCT
AGTCCCAACCCCTATGTCTCCCTCCTCGAAATCAGTGAGCACTCCCAGTGAAGCTGGAAGCCAAGACTCAGGCGATCTGGGGCCATTAAC
AAGGACCCTGCAGTGGGACACAGACCCCTCAGTGCTCCAGCTGCAGTCAGACTCAGAACTTGGAAGAAGACTGCATAAACTGGGCGTGTC
AAAGGTCACCCAAGTGGATTTCCTGCCAAGGGAAGTAGTGTCCTACTCAAAGGAGACCCAGACTCCTCTTGCCACGCATCAGTCTGAAGG
TTACTGGTTGCCTAGCTATAAATTGAAGTCTTCCTGGGCCACAGGCCTCCATCTCTCTGTCTTGTTTGGCCATGTGGAATGTCTTCTGGT
GCTACTGGACCACAATGCTACAATCAACTGTAGACCCAATGGGAAAACCCCTCTTCACGTGGCTTGTGAAATGGCCAATGTGGATTGTGT
TAAGATCCTCTGTGATCGTGGGGCAAAGCTCAATTGCTACTCCTTAAGTGGACACACAGCTTTGCACTTTTGTACAACTCCAAGTTCCAT
TCTCTGTGCCAAGCAATTGGTTTGGAGAGGGGCGAATGTGAACATGAAGACCAACAACCAAGATGAGGAGACGCCCTTGCACACGGCTGC
CCACTTCGGCCTTTCGGAGCTGGTGGCCTTCTACGTGGAACACGGGGCCATAGTGGACAGCGTGAATGCCCACATGGAGACCCCCCTGGC
CATCGCCGCCTACTGGGCCCTCCGCTTTAAGGAGCAGGAGTACAGCACGGAGCACCACCTGGTCTGCCGCATGCTGCTTGACTACAAAGC
CGAAGTCAATGCCCGAGATGACGACTTTAAATCTCCCCTCCACAAGGCAGCCTGGAACTGTGACCACGTGCTCATGCACATGATGCTGGA
AGCTGGCGCCGAAGCCAATCTCATGGATATCAACGGCTGTGCTGCCATCCAGTACGTGCTGAAGGTCACCTCCGTGCGCCCTGCTGCCCA
GCCTGAGATCTGCTACCAGCTCCTGTTGAACCATGGGGCTGCCCGAATATACCCTCCACAGTTCCATAAGGTGATACAGGCCTGCCATTC
TTGTCCTAAAGCAATTGAAGTTGTAGTCAATGCCTATGAACACATCAGATGGAACACAAAGTGGAGAAGAGCTATCCCCGATGATGACTT
GGAGAAATACTGGGATTTTTACCACTCTCTCTTTACTGTGTGCTGTAACTCTCCAAGGACTCTCATGCACTTATCGAGATGTGCCATTAG
AAGAACATTACACAACAGATGCCATAGAGCAATTCCTTTGCTTTCCCTCCCATTGTCATTGAAAAAGTACTTGCTTTTAGAGCCAGAGGG
AATTATTTATTAAGCCTTATGAGACAGCAGTTCCCAATCCTAGGTATTTAAGTGGACTTGCTGGGTAGACACAGTTTGCCTAAATAAAAT
GGTACTTGGGTTGATTATAACACTTCAGGGATTTCAAAACACTTTACAAACACTGCCATTAATCCTAGAATATCATGGTATGGGGAAATA
AAGAAGAAGTAAAGTTAAGGAATTTTCAAAGACAAGGATGTATTCAGAATGTACTGATAGAACAGTAATAACTAATATGTATAGTGTTCT
TACTAAGTACCTGAAATATTTTTGTAAAACTTCTTATATCTTATCTCATCTGAAATGGGACCCAGGTTTTCTTCCAACCAATATAATTCT
GTGCCTTATCAGTAATATGTTTACATTCTCATTCAAATGGCCATATAGCAGGCTTTGCAATTGGCCTCTTAAACTTGGTGTTTTCCCCCA
TTACCCCTTAGCAGTAATTACTGTCACTAGTTTTGCAAACTCCTACTCCCCAAACCAAGCTACTCAAGTTTATTTCAGTGATGAAGGCAT
ATGAGCATAGTCAAAACAAGGAGATCTTGGAGTCAAATTAGAAATGAGAAAGAAACATCAGTCCAGTTAATAGTCAAGAATGGACATTTG
AACCAGACATCACTGAGCCAGAGACTGGAGATGCAAAGATGAGTCCCATGTGACTCCTGCCTTCCAGGATCTCACCATTTAGCAGAGGAT
CCAGACATACACACAGCTAACTGCAATATAAAGTGATGGGGCAAGAGTACAGGTGCAGACTCACTTTTAATGCTTATCTTTCAAAGTTGT
GTTTCTGACATGAAGTGTGATTTTTCTTTTAAGCATGAAGTTAAAGAGTGAAGGGGTTATGTAAAGTAGAGGGATCTCCTGCTCTTGTTA
GGGTATTTTTAAGGTTTTTTCTAGATAGTGTGTCTTTTTGGTATGGTTTCTTGGTTAGTATTAATACTTTCCCAGACTCCTTGAGAAAAA
TATTGCACACTCAATGGCTCCAGTGCATGTGACAAGGAAGCATAGGAAAATGGGGGAAAGAAAGTGTGTGAGGGGACCTAGTTGATTACT
TCGGTCTTTTTATGTAGCAGACTGACATTTCATAGCATTGTAGCTAAGAGATAAGGAGCACTTTGCTAGTGACAGTGGGCTACGAAAAGT
AAATAGAGAGACTTTTTGAAAATGGTAAAAGTTTGAGAAACTTGGGAAGATTAGTGTGTTAATCAGGCTTGCTAGTTAGTGGATTGCAGA
AAGAAAAATGTAGGTGATTAAGCTCTGGGCCTTGTGGTTTATGAGGTCAATTTTGCTTCACTTTTTTTTTTGTTCTTGCTATAATCACTT
TTAGATAAGCTCATTGCTCTTAGCATCATTTTTTAGAGGTTAAAGCAGAAGTAAATTGCAAACAAATCTGTCAGTTGTGAGCAGATTTCT
TTTATGTGTGTGGTTCTCCATCATATTTAACTTTGGATGCTGGAGTGTTGAATAGAGATGATGTCAGATATTCCAATAGGCTATCATTTA
ATGTTAACTGGCAATCACCTAACTGGTTAATCTCAGTTGAGACTGTGCTTCTGAACTGGGATTGTCTTACTCCCAGGGCTGTGTAAGAAA
AGTCATAGGTGGATACAATAATCTCTTTTAAGTATCAGTTTTACTCAGATATTTTGGTGGAGATATTTTGTACTAAAACAAGATCTATAT
CATGGAATAGAATGCTGAATTTGTATGAATTATTCACATAAAGCTTGATCTTTCAAAAAATAGTTTGCTTGCAGCAAGTGGTATTAGAAC
ACATCCTAAAACAGAATGAAATGATGTCTTTTGCAGCAACTTGGATGGAGCTGGAGGCCATTATTCTAAGTGAAGTAACTCAGGAATGGA
AAGTGAAATACCATATGTTCTCACTTATAAGTGGGAGCTAAGCAATGAGGATGCAAAGACATCCAGAGTGATATAATGGACTATGGGGAC
TTGCAAGGGGAAGCTTGAGAGTGGGGTGAGGGATAAAAGACTACATATTGGGTACAGTGTACACTGCTCCAGTGATGGGTGCACTAAAAT
CTCAAAATTCACCACTAAAGAATGTATCCATGTAACCAAAAACCACCTGTACCCCCAAAACTATTGAAATCTTAAAATAGTAATAATTAA
CAAAGTAAAACAAGATCACACCCTGGAACAATTGGAGGATTGCTTGCTGCCCTGCATCTTAAGGCGTATTCTAGCAGCAAAGCTTGTGAT
GCACTGACTTGGGGCAAGTAAAACTGATGCTGAGGACAAAGGGAGAAGATGTTCCTCGCCCAGGGAAATGAAAACTTTTCTTATTCACCT
TGCTTGTGCTTAAACACTTATGTTCATCTAGTGTAGAATACATGGCTACTTGTTTGTAATTTTTTTATTGGTGGAATTAAAGTAATTTTT
CCTTATCTTTGAACTTTTATTTAGAGAACTTAAATAAAGCTCTTCTGTCTCCTTTC

>24610_24610_4_DYNC1I1-ASB4_DYNC1I1_chr7_95499310_ENST00000447467_ASB4_chr7_95125070_ENST00000325885_length(amino acids)=552AA_BP=188
MPPPRSRRRLGEPSSAAAERVQETNMSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQS
IGISPEPPLVPTPMSPSSKSVSTPSEAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGRRLHKLGVSKVTQVDFLPREVVSYSKETQT
PLATHQSEGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTAL
HFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLV
CRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQF
HKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPDDDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLK
KYLLLEPEGIIY

--------------------------------------------------------------
>24610_24610_5_DYNC1I1-ASB4_DYNC1I1_chr7_95499310_ENST00000457059_ASB4_chr7_95125070_ENST00000325885_length(transcript)=4157nt_BP=590nt
ATATCTCTAGGGGTTTATGACAGGCTGTTTTCTTTTCTCAGTGTGGGGATGAATTGCTCCATTATCATCTAAATTGGAAGTCATGATGAT
GGAAACCAACATGTCTGACAAAAGTGACTTAAAAGCTGAGCTAGAGCGCAAAAAGCAGCGCTTAGCACAGATAAGAGAAGAGAAGAAACG
GAAGGAAGAGGAGAGGAAAAAGAAAGAGGCTGATATGCAGCAGAAGAAAGAACCCGTTCAGGACGACTCTGATCTGGATCGCAAACGACG
AGAGACAGAGGCTTTGCTGCAAAGCATTGGTATCTCACCGGAGCCGCCTCTAGTCCCAACCCCTATGTCTCCCTCCTCGAAATCAGTGAG
CACTCCCAGTGAAGCTGGAAGCCAAGACTCAGGCGATCTGGGGCCATTAACAAGGACCCTGCAGTGGGACACAGACCCCTCAGTGCTCCA
GCTGCAGTCAGACTCAGAACTTGGAAGAAGACTGCATAAACTGGGCGTGTCAAAGGTCACCCAAGTGGATTTCCTGCCAAGGGAAGTAGT
GTCCTACTCAAAGGAGACCCAGACTCCTCTTGCCACGCATCAGTCTGAAGGTTACTGGTTGCCTAGCTATAAATTGAAGTCTTCCTGGGC
CACAGGCCTCCATCTCTCTGTCTTGTTTGGCCATGTGGAATGTCTTCTGGTGCTACTGGACCACAATGCTACAATCAACTGTAGACCCAA
TGGGAAAACCCCTCTTCACGTGGCTTGTGAAATGGCCAATGTGGATTGTGTTAAGATCCTCTGTGATCGTGGGGCAAAGCTCAATTGCTA
CTCCTTAAGTGGACACACAGCTTTGCACTTTTGTACAACTCCAAGTTCCATTCTCTGTGCCAAGCAATTGGTTTGGAGAGGGGCGAATGT
GAACATGAAGACCAACAACCAAGATGAGGAGACGCCCTTGCACACGGCTGCCCACTTCGGCCTTTCGGAGCTGGTGGCCTTCTACGTGGA
ACACGGGGCCATAGTGGACAGCGTGAATGCCCACATGGAGACCCCCCTGGCCATCGCCGCCTACTGGGCCCTCCGCTTTAAGGAGCAGGA
GTACAGCACGGAGCACCACCTGGTCTGCCGCATGCTGCTTGACTACAAAGCCGAAGTCAATGCCCGAGATGACGACTTTAAATCTCCCCT
CCACAAGGCAGCCTGGAACTGTGACCACGTGCTCATGCACATGATGCTGGAAGCTGGCGCCGAAGCCAATCTCATGGATATCAACGGCTG
TGCTGCCATCCAGTACGTGCTGAAGGTCACCTCCGTGCGCCCTGCTGCCCAGCCTGAGATCTGCTACCAGCTCCTGTTGAACCATGGGGC
TGCCCGAATATACCCTCCACAGTTCCATAAGGTGATACAGGCCTGCCATTCTTGTCCTAAAGCAATTGAAGTTGTAGTCAATGCCTATGA
ACACATCAGATGGAACACAAAGTGGAGAAGAGCTATCCCCGATGATGACTTGGAGAAATACTGGGATTTTTACCACTCTCTCTTTACTGT
GTGCTGTAACTCTCCAAGGACTCTCATGCACTTATCGAGATGTGCCATTAGAAGAACATTACACAACAGATGCCATAGAGCAATTCCTTT
GCTTTCCCTCCCATTGTCATTGAAAAAGTACTTGCTTTTAGAGCCAGAGGGAATTATTTATTAAGCCTTATGAGACAGCAGTTCCCAATC
CTAGGTATTTAAGTGGACTTGCTGGGTAGACACAGTTTGCCTAAATAAAATGGTACTTGGGTTGATTATAACACTTCAGGGATTTCAAAA
CACTTTACAAACACTGCCATTAATCCTAGAATATCATGGTATGGGGAAATAAAGAAGAAGTAAAGTTAAGGAATTTTCAAAGACAAGGAT
GTATTCAGAATGTACTGATAGAACAGTAATAACTAATATGTATAGTGTTCTTACTAAGTACCTGAAATATTTTTGTAAAACTTCTTATAT
CTTATCTCATCTGAAATGGGACCCAGGTTTTCTTCCAACCAATATAATTCTGTGCCTTATCAGTAATATGTTTACATTCTCATTCAAATG
GCCATATAGCAGGCTTTGCAATTGGCCTCTTAAACTTGGTGTTTTCCCCCATTACCCCTTAGCAGTAATTACTGTCACTAGTTTTGCAAA
CTCCTACTCCCCAAACCAAGCTACTCAAGTTTATTTCAGTGATGAAGGCATATGAGCATAGTCAAAACAAGGAGATCTTGGAGTCAAATT
AGAAATGAGAAAGAAACATCAGTCCAGTTAATAGTCAAGAATGGACATTTGAACCAGACATCACTGAGCCAGAGACTGGAGATGCAAAGA
TGAGTCCCATGTGACTCCTGCCTTCCAGGATCTCACCATTTAGCAGAGGATCCAGACATACACACAGCTAACTGCAATATAAAGTGATGG
GGCAAGAGTACAGGTGCAGACTCACTTTTAATGCTTATCTTTCAAAGTTGTGTTTCTGACATGAAGTGTGATTTTTCTTTTAAGCATGAA
GTTAAAGAGTGAAGGGGTTATGTAAAGTAGAGGGATCTCCTGCTCTTGTTAGGGTATTTTTAAGGTTTTTTCTAGATAGTGTGTCTTTTT
GGTATGGTTTCTTGGTTAGTATTAATACTTTCCCAGACTCCTTGAGAAAAATATTGCACACTCAATGGCTCCAGTGCATGTGACAAGGAA
GCATAGGAAAATGGGGGAAAGAAAGTGTGTGAGGGGACCTAGTTGATTACTTCGGTCTTTTTATGTAGCAGACTGACATTTCATAGCATT
GTAGCTAAGAGATAAGGAGCACTTTGCTAGTGACAGTGGGCTACGAAAAGTAAATAGAGAGACTTTTTGAAAATGGTAAAAGTTTGAGAA
ACTTGGGAAGATTAGTGTGTTAATCAGGCTTGCTAGTTAGTGGATTGCAGAAAGAAAAATGTAGGTGATTAAGCTCTGGGCCTTGTGGTT
TATGAGGTCAATTTTGCTTCACTTTTTTTTTTGTTCTTGCTATAATCACTTTTAGATAAGCTCATTGCTCTTAGCATCATTTTTTAGAGG
TTAAAGCAGAAGTAAATTGCAAACAAATCTGTCAGTTGTGAGCAGATTTCTTTTATGTGTGTGGTTCTCCATCATATTTAACTTTGGATG
CTGGAGTGTTGAATAGAGATGATGTCAGATATTCCAATAGGCTATCATTTAATGTTAACTGGCAATCACCTAACTGGTTAATCTCAGTTG
AGACTGTGCTTCTGAACTGGGATTGTCTTACTCCCAGGGCTGTGTAAGAAAAGTCATAGGTGGATACAATAATCTCTTTTAAGTATCAGT
TTTACTCAGATATTTTGGTGGAGATATTTTGTACTAAAACAAGATCTATATCATGGAATAGAATGCTGAATTTGTATGAATTATTCACAT
AAAGCTTGATCTTTCAAAAAATAGTTTGCTTGCAGCAAGTGGTATTAGAACACATCCTAAAACAGAATGAAATGATGTCTTTTGCAGCAA
CTTGGATGGAGCTGGAGGCCATTATTCTAAGTGAAGTAACTCAGGAATGGAAAGTGAAATACCATATGTTCTCACTTATAAGTGGGAGCT
AAGCAATGAGGATGCAAAGACATCCAGAGTGATATAATGGACTATGGGGACTTGCAAGGGGAAGCTTGAGAGTGGGGTGAGGGATAAAAG
ACTACATATTGGGTACAGTGTACACTGCTCCAGTGATGGGTGCACTAAAATCTCAAAATTCACCACTAAAGAATGTATCCATGTAACCAA
AAACCACCTGTACCCCCAAAACTATTGAAATCTTAAAATAGTAATAATTAACAAAGTAAAACAAGATCACACCCTGGAACAATTGGAGGA
TTGCTTGCTGCCCTGCATCTTAAGGCGTATTCTAGCAGCAAAGCTTGTGATGCACTGACTTGGGGCAAGTAAAACTGATGCTGAGGACAA
AGGGAGAAGATGTTCCTCGCCCAGGGAAATGAAAACTTTTCTTATTCACCTTGCTTGTGCTTAAACACTTATGTTCATCTAGTGTAGAAT
ACATGGCTACTTGTTTGTAATTTTTTTATTGGTGGAATTAAAGTAATTTTTCCTTATCTTTGAACTTTTATTTAGAGAACTTAAATAAAG
CTCTTCTGTCTCCTTTC

>24610_24610_5_DYNC1I1-ASB4_DYNC1I1_chr7_95499310_ENST00000457059_ASB4_chr7_95125070_ENST00000325885_length(amino acids)=536AA_BP=172
MEVMMMETNMSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQSIGISPEPPLVPTPMSP
SSKSVSTPSEAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGRRLHKLGVSKVTQVDFLPREVVSYSKETQTPLATHQSEGYWLPSYK
LKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLV
WRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDD
DFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEV
VVNAYEHIRWNTKWRRAIPDDDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLEPEGIIY

--------------------------------------------------------------
>24610_24610_6_DYNC1I1-ASB4_DYNC1I1_chr7_95499310_ENST00000537881_ASB4_chr7_95125070_ENST00000325885_length(transcript)=4186nt_BP=619nt
GAGAGAGGAAGTGATCGCTCCCGGAGGAGCGCGAGCCGAGCGGCCGGCGCAGCGTGAGACAGCACATCCTGCCCGCGCCGGCCCCGCCAC
CTTCGGGAGCCGCCTGCACCAACGCTGCCGCCGCCCAGGAGCCGCCGCCGGCTCGGGGAGCCCAGTTCCGCCGCTGCCGAGCGCGTCCAG
GAAACCAACATGTCTGACAAAAGTGACTTAAAAGCTGAGCTAGAGCGCAAAAAGCAGCGCTTAGCACAGATAAGAGAAGAGAAGAAACGG
AAGGAAGAGGAGAGGAAAAAGAAAGAGGCTGATATGCAGCAGAAGAAAGAACCCGTTCAGGACGACTCTGATCTGGATCGCAAACGACGA
GAGACAGAGGCTTTGCTGCAAAGCATTGGTATCTCACCGGAGCCGCCTCTAGTCCCAACCCCTATGTCTCCCTCCTCGAAATCAGTGAGC
ACTCCCAGTGAAGCTGGAAGCCAAGACTCAGGCGATCTGGGGCCATTAACAAGAAGAAGACTGCATAAACTGGGCGTGTCAAAGGTCACC
CAAGTGGATTTCCTGCCAAGGGAAGTAGTGTCCTACTCAAAGGAGACCCAGACTCCTCTTGCCACGCATCAGTCTGAAGGTTACTGGTTG
CCTAGCTATAAATTGAAGTCTTCCTGGGCCACAGGCCTCCATCTCTCTGTCTTGTTTGGCCATGTGGAATGTCTTCTGGTGCTACTGGAC
CACAATGCTACAATCAACTGTAGACCCAATGGGAAAACCCCTCTTCACGTGGCTTGTGAAATGGCCAATGTGGATTGTGTTAAGATCCTC
TGTGATCGTGGGGCAAAGCTCAATTGCTACTCCTTAAGTGGACACACAGCTTTGCACTTTTGTACAACTCCAAGTTCCATTCTCTGTGCC
AAGCAATTGGTTTGGAGAGGGGCGAATGTGAACATGAAGACCAACAACCAAGATGAGGAGACGCCCTTGCACACGGCTGCCCACTTCGGC
CTTTCGGAGCTGGTGGCCTTCTACGTGGAACACGGGGCCATAGTGGACAGCGTGAATGCCCACATGGAGACCCCCCTGGCCATCGCCGCC
TACTGGGCCCTCCGCTTTAAGGAGCAGGAGTACAGCACGGAGCACCACCTGGTCTGCCGCATGCTGCTTGACTACAAAGCCGAAGTCAAT
GCCCGAGATGACGACTTTAAATCTCCCCTCCACAAGGCAGCCTGGAACTGTGACCACGTGCTCATGCACATGATGCTGGAAGCTGGCGCC
GAAGCCAATCTCATGGATATCAACGGCTGTGCTGCCATCCAGTACGTGCTGAAGGTCACCTCCGTGCGCCCTGCTGCCCAGCCTGAGATC
TGCTACCAGCTCCTGTTGAACCATGGGGCTGCCCGAATATACCCTCCACAGTTCCATAAGGTGATACAGGCCTGCCATTCTTGTCCTAAA
GCAATTGAAGTTGTAGTCAATGCCTATGAACACATCAGATGGAACACAAAGTGGAGAAGAGCTATCCCCGATGATGACTTGGAGAAATAC
TGGGATTTTTACCACTCTCTCTTTACTGTGTGCTGTAACTCTCCAAGGACTCTCATGCACTTATCGAGATGTGCCATTAGAAGAACATTA
CACAACAGATGCCATAGAGCAATTCCTTTGCTTTCCCTCCCATTGTCATTGAAAAAGTACTTGCTTTTAGAGCCAGAGGGAATTATTTAT
TAAGCCTTATGAGACAGCAGTTCCCAATCCTAGGTATTTAAGTGGACTTGCTGGGTAGACACAGTTTGCCTAAATAAAATGGTACTTGGG
TTGATTATAACACTTCAGGGATTTCAAAACACTTTACAAACACTGCCATTAATCCTAGAATATCATGGTATGGGGAAATAAAGAAGAAGT
AAAGTTAAGGAATTTTCAAAGACAAGGATGTATTCAGAATGTACTGATAGAACAGTAATAACTAATATGTATAGTGTTCTTACTAAGTAC
CTGAAATATTTTTGTAAAACTTCTTATATCTTATCTCATCTGAAATGGGACCCAGGTTTTCTTCCAACCAATATAATTCTGTGCCTTATC
AGTAATATGTTTACATTCTCATTCAAATGGCCATATAGCAGGCTTTGCAATTGGCCTCTTAAACTTGGTGTTTTCCCCCATTACCCCTTA
GCAGTAATTACTGTCACTAGTTTTGCAAACTCCTACTCCCCAAACCAAGCTACTCAAGTTTATTTCAGTGATGAAGGCATATGAGCATAG
TCAAAACAAGGAGATCTTGGAGTCAAATTAGAAATGAGAAAGAAACATCAGTCCAGTTAATAGTCAAGAATGGACATTTGAACCAGACAT
CACTGAGCCAGAGACTGGAGATGCAAAGATGAGTCCCATGTGACTCCTGCCTTCCAGGATCTCACCATTTAGCAGAGGATCCAGACATAC
ACACAGCTAACTGCAATATAAAGTGATGGGGCAAGAGTACAGGTGCAGACTCACTTTTAATGCTTATCTTTCAAAGTTGTGTTTCTGACA
TGAAGTGTGATTTTTCTTTTAAGCATGAAGTTAAAGAGTGAAGGGGTTATGTAAAGTAGAGGGATCTCCTGCTCTTGTTAGGGTATTTTT
AAGGTTTTTTCTAGATAGTGTGTCTTTTTGGTATGGTTTCTTGGTTAGTATTAATACTTTCCCAGACTCCTTGAGAAAAATATTGCACAC
TCAATGGCTCCAGTGCATGTGACAAGGAAGCATAGGAAAATGGGGGAAAGAAAGTGTGTGAGGGGACCTAGTTGATTACTTCGGTCTTTT
TATGTAGCAGACTGACATTTCATAGCATTGTAGCTAAGAGATAAGGAGCACTTTGCTAGTGACAGTGGGCTACGAAAAGTAAATAGAGAG
ACTTTTTGAAAATGGTAAAAGTTTGAGAAACTTGGGAAGATTAGTGTGTTAATCAGGCTTGCTAGTTAGTGGATTGCAGAAAGAAAAATG
TAGGTGATTAAGCTCTGGGCCTTGTGGTTTATGAGGTCAATTTTGCTTCACTTTTTTTTTTGTTCTTGCTATAATCACTTTTAGATAAGC
TCATTGCTCTTAGCATCATTTTTTAGAGGTTAAAGCAGAAGTAAATTGCAAACAAATCTGTCAGTTGTGAGCAGATTTCTTTTATGTGTG
TGGTTCTCCATCATATTTAACTTTGGATGCTGGAGTGTTGAATAGAGATGATGTCAGATATTCCAATAGGCTATCATTTAATGTTAACTG
GCAATCACCTAACTGGTTAATCTCAGTTGAGACTGTGCTTCTGAACTGGGATTGTCTTACTCCCAGGGCTGTGTAAGAAAAGTCATAGGT
GGATACAATAATCTCTTTTAAGTATCAGTTTTACTCAGATATTTTGGTGGAGATATTTTGTACTAAAACAAGATCTATATCATGGAATAG
AATGCTGAATTTGTATGAATTATTCACATAAAGCTTGATCTTTCAAAAAATAGTTTGCTTGCAGCAAGTGGTATTAGAACACATCCTAAA
ACAGAATGAAATGATGTCTTTTGCAGCAACTTGGATGGAGCTGGAGGCCATTATTCTAAGTGAAGTAACTCAGGAATGGAAAGTGAAATA
CCATATGTTCTCACTTATAAGTGGGAGCTAAGCAATGAGGATGCAAAGACATCCAGAGTGATATAATGGACTATGGGGACTTGCAAGGGG
AAGCTTGAGAGTGGGGTGAGGGATAAAAGACTACATATTGGGTACAGTGTACACTGCTCCAGTGATGGGTGCACTAAAATCTCAAAATTC
ACCACTAAAGAATGTATCCATGTAACCAAAAACCACCTGTACCCCCAAAACTATTGAAATCTTAAAATAGTAATAATTAACAAAGTAAAA
CAAGATCACACCCTGGAACAATTGGAGGATTGCTTGCTGCCCTGCATCTTAAGGCGTATTCTAGCAGCAAAGCTTGTGATGCACTGACTT
GGGGCAAGTAAAACTGATGCTGAGGACAAAGGGAGAAGATGTTCCTCGCCCAGGGAAATGAAAACTTTTCTTATTCACCTTGCTTGTGCT
TAAACACTTATGTTCATCTAGTGTAGAATACATGGCTACTTGTTTGTAATTTTTTTATTGGTGGAATTAAAGTAATTTTTCCTTATCTTT
GAACTTTTATTTAGAGAACTTAAATAAAGCTCTTCTGTCTCCTTTC

>24610_24610_6_DYNC1I1-ASB4_DYNC1I1_chr7_95499310_ENST00000537881_ASB4_chr7_95125070_ENST00000325885_length(amino acids)=532AA_BP=168
MPPPRSRRRLGEPSSAAAERVQETNMSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQS
IGISPEPPLVPTPMSPSSKSVSTPSEAGSQDSGDLGPLTRRRLHKLGVSKVTQVDFLPREVVSYSKETQTPLATHQSEGYWLPSYKLKSS
WATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGA
NVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKS
PLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNA
YEHIRWNTKWRRAIPDDDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLEPEGIIY

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DYNC1I1-ASB4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	DYNC1I1	chr7:95499310	chr7:95125070	ENST00000324972	+	6	17	2_123	180.33333333333334	646.0	DCTN1
Hgene	DYNC1I1	chr7:95499310	chr7:95125070	ENST00000359388	+	5	16	2_123	143.33333333333334	609.0	DCTN1
Hgene	DYNC1I1	chr7:95499310	chr7:95125070	ENST00000447467	+	6	17	2_123	163.33333333333334	629.0	DCTN1
Hgene	DYNC1I1	chr7:95499310	chr7:95125070	ENST00000457059	+	6	17	2_123	163.33333333333334	629.0	DCTN1
Hgene	DYNC1I1	chr7:95499310	chr7:95125070	ENST00000324972	+	6	17	147_163	180.33333333333334	646.0	DYNLT1
Hgene	DYNC1I1	chr7:95499310	chr7:95125070	ENST00000447467	+	6	17	147_163	163.33333333333334	629.0	DYNLT1
Hgene	DYNC1I1	chr7:95499310	chr7:95125070	ENST00000457059	+	6	17	147_163	163.33333333333334	629.0	DYNLT1

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	DYNC1I1	chr7:95499310	chr7:95125070	ENST00000359388	+	5	16	147_163	143.33333333333334	609.0	DYNLT1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for DYNC1I1-ASB4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DYNC1I1-ASB4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	DYNC1I1	C4721453	Peripheral Nervous System Diseases	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:DYNC1I1-ASB4 (FusionGDB2 ID:HG1780TG51666)

Fusion Gene Summary for DYNC1I1-ASB4

Fusion Gene ORF analysis for DYNC1I1-ASB4

Fusion Genomic Features for DYNC1I1-ASB4

Fusion Protein Features for DYNC1I1-ASB4

Fusion Gene Sequence for DYNC1I1-ASB4

Fusion Gene PPI Analysis for DYNC1I1-ASB4

Related Drugs for DYNC1I1-ASB4

Related Diseases for DYNC1I1-ASB4

Fusion Gene Studies
in Kim Lab