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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNM2-ILF3 (FusionGDB2 ID:HG1785TG3609)

Fusion Gene Summary for DNM2-ILF3

check button Fusion gene summary
Fusion gene informationFusion gene name: DNM2-ILF3
Fusion gene ID: hg1785tg3609
HgeneTgene
Gene symbol

DNM2

ILF3

Gene ID

1785

3609

Gene namedynamin 2interleukin enhancer binding factor 3
SynonymsCMT2M|CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII|LCCS5CBTF|DRBF|DRBP76|MMP4|MPHOSPH4|MPP4|MPP4110|NF-AT-90|NF110|NF110b|NF90|NF90a|NF90b|NF90c|NF90ctv|NFAR|NFAR-1|NFAR-2|NFAR110|NFAR2|NFAR90|TCP110|TCP80
Cytomap('DNM2')('ILF3')

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptiondynamin-2dynamin IIinterleukin enhancer-binding factor 3M phase phosphoprotein 4, nuclear factor associated with DS RNAM-phase phosphoprotein 4double-stranded RNA-binding protein, 76 kDdsRNA binding protein NFAR-2/MPP4interleukin enhancer binding factor 3, 90kDinterle
Modification date2020032920200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000314646, ENST00000355667, 
ENST00000359692, ENST00000389253, 
ENST00000408974, ENST00000585892, 
ENST00000591819, 
ENST00000591819, 
ENST00000314646, ENST00000355667, 
ENST00000359692, ENST00000389253, 
ENST00000408974, ENST00000585892, 
Fusion gene scores* DoF score36 X 17 X 17=1040417 X 23 X 6=2346
# samples 4925
** MAII scorelog2(49/10404*10)=-4.40821274494042
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(25/2346*10)=-3.23020301336642
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNM2 [Title/Abstract] AND ILF3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNM2(10934575)-ILF3(10799226), # samples:2
DNM2(10829079)-ILF3(10787839), # samples:2
Anticipated loss of major functional domain due to fusion event.DNM2-ILF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-ILF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-ILF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-ILF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ILF3-DNM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ILF3-DNM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-ILF3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
DNM2-ILF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNM2

GO:1903526

negative regulation of membrane tubulation

18388313

TgeneILF3

GO:0006468

protein phosphorylation

21123651

TgeneILF3

GO:0045892

negative regulation of transcription, DNA-templated

11739746

TgeneILF3

GO:0045893

positive regulation of transcription, DNA-templated

11739746


check buttonFusion gene breakpoints across DNM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ILF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-GM-A2DB-01ADNM2chr19

10934575

-ILF3chr19

10798022

+
ChimerDB4BRCATCGA-GM-A2DB-01ADNM2chr19

10934575

+ILF3chr19

10799226

+
ChimerDB4BRCATCGA-UU-A93S-01ADNM2chr19

10829079

-ILF3chr19

10787839

+
ChimerDB4BRCATCGA-UU-A93S-01ADNM2chr19

10829079

+ILF3chr19

10787839

+
ChimerDB4UCECTCGA-E6-A1LZ-01ADNM2chr19

10887892

+ILF3chr19

10789289

+
ChimerDB4UCECTCGA-E6-A1LZDNM2chr19

10887892

+ILF3chr19

10789288

+


Top

Fusion Gene ORF analysis for DNM2-ILF3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000314646ENST00000586544DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-3UTRENST00000355667ENST00000586544DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-3UTRENST00000359692ENST00000586544DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-3UTRENST00000389253ENST00000586544DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-3UTRENST00000408974ENST00000586544DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-3UTRENST00000585892ENST00000586544DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000314646ENST00000250241DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000314646ENST00000250241DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000314646ENST00000318511DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000314646ENST00000318511DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000314646ENST00000407004DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000314646ENST00000407004DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000314646ENST00000420083DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000314646ENST00000420083DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000314646ENST00000449870DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000314646ENST00000449870DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000314646ENST00000586544DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000314646ENST00000586544DNM2chr19

10829079

+ILF3chr19

10787839

+
5CDS-intronENST00000314646ENST00000586544DNM2chr19

10887892

+ILF3chr19

10789289

+
5CDS-intronENST00000314646ENST00000586544DNM2chr19

10887892

+ILF3chr19

10789288

+
5CDS-intronENST00000314646ENST00000588657DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000314646ENST00000588657DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000314646ENST00000589998DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000314646ENST00000589998DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000314646ENST00000590261DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000314646ENST00000590261DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000314646ENST00000592763DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000314646ENST00000592763DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000355667ENST00000250241DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000355667ENST00000250241DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000355667ENST00000318511DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000355667ENST00000318511DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000355667ENST00000407004DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000355667ENST00000407004DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000355667ENST00000420083DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000355667ENST00000420083DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000355667ENST00000449870DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000355667ENST00000449870DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000355667ENST00000586544DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000355667ENST00000586544DNM2chr19

10829079

+ILF3chr19

10787839

+
5CDS-intronENST00000355667ENST00000586544DNM2chr19

10887892

+ILF3chr19

10789289

+
5CDS-intronENST00000355667ENST00000586544DNM2chr19

10887892

+ILF3chr19

10789288

+
5CDS-intronENST00000355667ENST00000588657DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000355667ENST00000588657DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000355667ENST00000589998DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000355667ENST00000589998DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000355667ENST00000590261DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000355667ENST00000590261DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000355667ENST00000592763DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000355667ENST00000592763DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000359692ENST00000250241DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000359692ENST00000250241DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000359692ENST00000318511DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000359692ENST00000318511DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000359692ENST00000407004DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000359692ENST00000407004DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000359692ENST00000420083DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000359692ENST00000420083DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000359692ENST00000449870DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000359692ENST00000449870DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000359692ENST00000586544DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000359692ENST00000586544DNM2chr19

10829079

+ILF3chr19

10787839

+
5CDS-intronENST00000359692ENST00000586544DNM2chr19

10887892

+ILF3chr19

10789289

+
5CDS-intronENST00000359692ENST00000586544DNM2chr19

10887892

+ILF3chr19

10789288

+
5CDS-intronENST00000359692ENST00000588657DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000359692ENST00000588657DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000359692ENST00000589998DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000359692ENST00000589998DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000359692ENST00000590261DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000359692ENST00000590261DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000359692ENST00000592763DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000359692ENST00000592763DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000389253ENST00000250241DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000389253ENST00000250241DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000389253ENST00000318511DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000389253ENST00000318511DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000389253ENST00000407004DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000389253ENST00000407004DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000389253ENST00000420083DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000389253ENST00000420083DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000389253ENST00000449870DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000389253ENST00000449870DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000389253ENST00000586544DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000389253ENST00000586544DNM2chr19

10829079

+ILF3chr19

10787839

+
5CDS-intronENST00000389253ENST00000586544DNM2chr19

10887892

+ILF3chr19

10789289

+
5CDS-intronENST00000389253ENST00000586544DNM2chr19

10887892

+ILF3chr19

10789288

+
5CDS-intronENST00000389253ENST00000588657DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000389253ENST00000588657DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000389253ENST00000589998DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000389253ENST00000589998DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000389253ENST00000590261DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000389253ENST00000590261DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000389253ENST00000592763DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000389253ENST00000592763DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000408974ENST00000250241DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000408974ENST00000250241DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000408974ENST00000318511DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000408974ENST00000318511DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000408974ENST00000407004DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000408974ENST00000407004DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000408974ENST00000420083DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000408974ENST00000420083DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000408974ENST00000449870DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000408974ENST00000449870DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000408974ENST00000586544DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000408974ENST00000586544DNM2chr19

10829079

+ILF3chr19

10787839

+
5CDS-intronENST00000408974ENST00000586544DNM2chr19

10887892

+ILF3chr19

10789289

+
5CDS-intronENST00000408974ENST00000586544DNM2chr19

10887892

+ILF3chr19

10789288

+
5CDS-intronENST00000408974ENST00000588657DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000408974ENST00000588657DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000408974ENST00000589998DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000408974ENST00000589998DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000408974ENST00000590261DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000408974ENST00000590261DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000408974ENST00000592763DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000408974ENST00000592763DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000585892ENST00000250241DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000585892ENST00000250241DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000585892ENST00000318511DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000585892ENST00000318511DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000585892ENST00000407004DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000585892ENST00000407004DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000585892ENST00000420083DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000585892ENST00000420083DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000585892ENST00000449870DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000585892ENST00000449870DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000585892ENST00000586544DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000585892ENST00000586544DNM2chr19

10829079

+ILF3chr19

10787839

+
5CDS-intronENST00000585892ENST00000586544DNM2chr19

10887892

+ILF3chr19

10789289

+
5CDS-intronENST00000585892ENST00000586544DNM2chr19

10887892

+ILF3chr19

10789288

+
5CDS-intronENST00000585892ENST00000588657DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000585892ENST00000588657DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000585892ENST00000589998DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000585892ENST00000589998DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000585892ENST00000590261DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000585892ENST00000590261DNM2chr19

10934575

+ILF3chr19

10799226

+
5CDS-intronENST00000585892ENST00000592763DNM2chr19

10934575

-ILF3chr19

10798022

+
5CDS-intronENST00000585892ENST00000592763DNM2chr19

10934575

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Frame-shiftENST00000314646ENST00000318511DNM2chr19

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Frame-shiftENST00000314646ENST00000449870DNM2chr19

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intron-3CDSENST00000591819ENST00000250241DNM2chr19

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intron-3CDSENST00000591819ENST00000250241DNM2chr19

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intron-3CDSENST00000591819ENST00000250241DNM2chr19

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intron-3CDSENST00000591819ENST00000318511DNM2chr19

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intron-3CDSENST00000591819ENST00000318511DNM2chr19

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intron-3CDSENST00000591819ENST00000318511DNM2chr19

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intron-3CDSENST00000591819ENST00000407004DNM2chr19

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intron-3CDSENST00000591819ENST00000407004DNM2chr19

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intron-3CDSENST00000591819ENST00000407004DNM2chr19

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intron-3CDSENST00000591819ENST00000420083DNM2chr19

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intron-3CDSENST00000591819ENST00000420083DNM2chr19

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intron-3CDSENST00000591819ENST00000420083DNM2chr19

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intron-3CDSENST00000591819ENST00000449870DNM2chr19

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intron-3CDSENST00000591819ENST00000449870DNM2chr19

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intron-3CDSENST00000591819ENST00000449870DNM2chr19

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intron-3CDSENST00000591819ENST00000588657DNM2chr19

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intron-3CDSENST00000591819ENST00000588657DNM2chr19

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intron-3CDSENST00000591819ENST00000588657DNM2chr19

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intron-3CDSENST00000591819ENST00000589998DNM2chr19

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intron-3CDSENST00000591819ENST00000589998DNM2chr19

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intron-3CDSENST00000591819ENST00000589998DNM2chr19

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intron-3CDSENST00000591819ENST00000590261DNM2chr19

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intron-3CDSENST00000591819ENST00000590261DNM2chr19

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intron-3CDSENST00000591819ENST00000590261DNM2chr19

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intron-3CDSENST00000591819ENST00000592763DNM2chr19

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intron-3CDSENST00000591819ENST00000592763DNM2chr19

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intron-3CDSENST00000591819ENST00000592763DNM2chr19

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intron-3UTRENST00000591819ENST00000586544DNM2chr19

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intron-intronENST00000591819ENST00000250241DNM2chr19

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intron-intronENST00000591819ENST00000250241DNM2chr19

10934575

+ILF3chr19

10799226

+
intron-intronENST00000591819ENST00000318511DNM2chr19

10934575

-ILF3chr19

10798022

+
intron-intronENST00000591819ENST00000318511DNM2chr19

10934575

+ILF3chr19

10799226

+
intron-intronENST00000591819ENST00000407004DNM2chr19

10934575

-ILF3chr19

10798022

+
intron-intronENST00000591819ENST00000407004DNM2chr19

10934575

+ILF3chr19

10799226

+
intron-intronENST00000591819ENST00000420083DNM2chr19

10934575

-ILF3chr19

10798022

+
intron-intronENST00000591819ENST00000420083DNM2chr19

10934575

+ILF3chr19

10799226

+
intron-intronENST00000591819ENST00000449870DNM2chr19

10934575

-ILF3chr19

10798022

+
intron-intronENST00000591819ENST00000449870DNM2chr19

10934575

+ILF3chr19

10799226

+
intron-intronENST00000591819ENST00000586544DNM2chr19

10934575

-ILF3chr19

10798022

+
intron-intronENST00000591819ENST00000586544DNM2chr19

10829079

+ILF3chr19

10787839

+
intron-intronENST00000591819ENST00000586544DNM2chr19

10887892

+ILF3chr19

10789289

+
intron-intronENST00000591819ENST00000586544DNM2chr19

10887892

+ILF3chr19

10789288

+
intron-intronENST00000591819ENST00000588657DNM2chr19

10934575

-ILF3chr19

10798022

+
intron-intronENST00000591819ENST00000588657DNM2chr19

10934575

+ILF3chr19

10799226

+
intron-intronENST00000591819ENST00000589998DNM2chr19

10934575

-ILF3chr19

10798022

+
intron-intronENST00000591819ENST00000589998DNM2chr19

10934575

+ILF3chr19

10799226

+
intron-intronENST00000591819ENST00000590261DNM2chr19

10934575

-ILF3chr19

10798022

+
intron-intronENST00000591819ENST00000590261DNM2chr19

10934575

+ILF3chr19

10799226

+
intron-intronENST00000591819ENST00000592763DNM2chr19

10934575

-ILF3chr19

10798022

+
intron-intronENST00000591819ENST00000592763DNM2chr19

10934575

+ILF3chr19

10799226

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for DNM2-ILF3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DNM2chr1910934575+ILF3chr1910799225+7.48E-050.99992526
DNM2chr1910829079+ILF3chr1910787838+5.32E-131
DNM2chr1910887892+ILF3chr1910789288+1.28E-121
DNM2chr1910887892+ILF3chr1910789288+1.28E-121
DNM2chr1910934575+ILF3chr1910799225+7.48E-050.99992526
DNM2chr1910829079+ILF3chr1910787838+5.32E-131
DNM2chr1910887892+ILF3chr1910789288+1.28E-121
DNM2chr1910887892+ILF3chr1910789288+1.28E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for DNM2-ILF3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:10934575/chr19:10799226)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM2chr19:10887892chr19:10789288ENST00000355667+521205_211229871.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789288ENST00000355667+52138_46229871.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789288ENST00000359692+520205_211229867.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789288ENST00000359692+52038_46229867.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789288ENST00000389253+521205_211229871.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789288ENST00000389253+52138_46229871.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789288ENST00000408974+520205_211229867.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789288ENST00000408974+52038_46229867.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789288ENST00000585892+521205_211229870.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789288ENST00000585892+52138_46229870.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789289ENST00000355667+521205_211229871.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789289ENST00000355667+52138_46229871.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789289ENST00000359692+520205_211229867.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789289ENST00000359692+52038_46229867.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789289ENST00000389253+521205_211229871.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789289ENST00000389253+52138_46229871.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789289ENST00000408974+520205_211229867.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789289ENST00000408974+52038_46229867.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789289ENST00000585892+521205_211229870.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789289ENST00000585892+52138_46229870.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789288ENST00000355667+521136_139229871.0RegionG3 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000355667+521205_208229871.0RegionG4 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000355667+52138_45229871.0RegionG1 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000355667+52164_66229871.0RegionG2 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000359692+520136_139229867.0RegionG3 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000359692+520205_208229867.0RegionG4 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000359692+52038_45229867.0RegionG1 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000359692+52064_66229867.0RegionG2 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000389253+521136_139229871.0RegionG3 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000389253+521205_208229871.0RegionG4 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000389253+52138_45229871.0RegionG1 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000389253+52164_66229871.0RegionG2 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000408974+520136_139229867.0RegionG3 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000408974+520205_208229867.0RegionG4 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000408974+52038_45229867.0RegionG1 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000408974+52064_66229867.0RegionG2 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000585892+521136_139229870.0RegionG3 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000585892+521205_208229870.0RegionG4 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000585892+52138_45229870.0RegionG1 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000585892+52164_66229870.0RegionG2 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000355667+521136_139229871.0RegionG3 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000355667+521205_208229871.0RegionG4 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000355667+52138_45229871.0RegionG1 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000355667+52164_66229871.0RegionG2 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000359692+520136_139229867.0RegionG3 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000359692+520205_208229867.0RegionG4 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000359692+52038_45229867.0RegionG1 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000359692+52064_66229867.0RegionG2 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000389253+521136_139229871.0RegionG3 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000389253+521205_208229871.0RegionG4 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000389253+52138_45229871.0RegionG1 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000389253+52164_66229871.0RegionG2 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000408974+520136_139229867.0RegionG3 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000408974+520205_208229867.0RegionG4 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000408974+52038_45229867.0RegionG1 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000408974+52064_66229867.0RegionG2 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000585892+521136_139229870.0RegionG3 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000585892+521205_208229870.0RegionG4 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000585892+52138_45229870.0RegionG1 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000585892+52164_66229870.0RegionG2 motif
TgeneILF3chr19:10887892chr19:10789288ENST00000250241317385_389186691.0Compositional biasNote=Poly-Lys
TgeneILF3chr19:10887892chr19:10789288ENST00000250241317634_637186691.0Compositional biasNote=Poly-Pro
TgeneILF3chr19:10887892chr19:10789288ENST00000250241317640_659186691.0Compositional biasNote=Arg/Gly-rich
TgeneILF3chr19:10887892chr19:10789288ENST00000250241317701_709186691.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789288ENST00000250241317794_798186691.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789288ENST00000318511420385_389186895.0Compositional biasNote=Poly-Lys
TgeneILF3chr19:10887892chr19:10789288ENST00000318511420634_637186895.0Compositional biasNote=Poly-Pro
TgeneILF3chr19:10887892chr19:10789288ENST00000318511420640_659186895.0Compositional biasNote=Arg/Gly-rich
TgeneILF3chr19:10887892chr19:10789288ENST00000318511420701_709186895.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789288ENST00000318511420794_798186895.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789288ENST00000407004418385_389186707.0Compositional biasNote=Poly-Lys
TgeneILF3chr19:10887892chr19:10789288ENST00000407004418634_637186707.0Compositional biasNote=Poly-Pro
TgeneILF3chr19:10887892chr19:10789288ENST00000407004418640_659186707.0Compositional biasNote=Arg/Gly-rich
TgeneILF3chr19:10887892chr19:10789288ENST00000407004418701_709186707.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789288ENST00000407004418794_798186707.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789288ENST00000420083418385_389186691.0Compositional biasNote=Poly-Lys
TgeneILF3chr19:10887892chr19:10789288ENST00000420083418634_637186691.0Compositional biasNote=Poly-Pro
TgeneILF3chr19:10887892chr19:10789288ENST00000420083418640_659186691.0Compositional biasNote=Arg/Gly-rich
TgeneILF3chr19:10887892chr19:10789288ENST00000420083418701_709186691.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789288ENST00000420083418794_798186691.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789288ENST00000449870420385_389186899.0Compositional biasNote=Poly-Lys
TgeneILF3chr19:10887892chr19:10789288ENST00000449870420634_637186899.0Compositional biasNote=Poly-Pro
TgeneILF3chr19:10887892chr19:10789288ENST00000449870420640_659186899.0Compositional biasNote=Arg/Gly-rich
TgeneILF3chr19:10887892chr19:10789288ENST00000449870420701_709186899.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789288ENST00000449870420794_798186899.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789288ENST00000588657319385_389186899.0Compositional biasNote=Poly-Lys
TgeneILF3chr19:10887892chr19:10789288ENST00000588657319634_637186899.0Compositional biasNote=Poly-Pro
TgeneILF3chr19:10887892chr19:10789288ENST00000588657319640_659186899.0Compositional biasNote=Arg/Gly-rich
TgeneILF3chr19:10887892chr19:10789288ENST00000588657319701_709186899.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789288ENST00000588657319794_798186899.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789288ENST00000589998418385_389186703.0Compositional biasNote=Poly-Lys
TgeneILF3chr19:10887892chr19:10789288ENST00000589998418634_637186703.0Compositional biasNote=Poly-Pro
TgeneILF3chr19:10887892chr19:10789288ENST00000589998418640_659186703.0Compositional biasNote=Arg/Gly-rich
TgeneILF3chr19:10887892chr19:10789288ENST00000589998418701_709186703.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789288ENST00000589998418794_798186703.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789288ENST00000590261319385_389186895.0Compositional biasNote=Poly-Lys
TgeneILF3chr19:10887892chr19:10789288ENST00000590261319634_637186895.0Compositional biasNote=Poly-Pro
TgeneILF3chr19:10887892chr19:10789288ENST00000590261319640_659186895.0Compositional biasNote=Arg/Gly-rich
TgeneILF3chr19:10887892chr19:10789288ENST00000590261319701_709186895.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789288ENST00000590261319794_798186895.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789288ENST00000592763316385_389186699.0Compositional biasNote=Poly-Lys
TgeneILF3chr19:10887892chr19:10789288ENST00000592763316634_637186699.0Compositional biasNote=Poly-Pro
TgeneILF3chr19:10887892chr19:10789288ENST00000592763316640_659186699.0Compositional biasNote=Arg/Gly-rich
TgeneILF3chr19:10887892chr19:10789288ENST00000592763316701_709186699.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789288ENST00000592763316794_798186699.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789289ENST00000250241317385_389186691.0Compositional biasNote=Poly-Lys
TgeneILF3chr19:10887892chr19:10789289ENST00000250241317634_637186691.0Compositional biasNote=Poly-Pro
TgeneILF3chr19:10887892chr19:10789289ENST00000250241317640_659186691.0Compositional biasNote=Arg/Gly-rich
TgeneILF3chr19:10887892chr19:10789289ENST00000250241317701_709186691.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789289ENST00000250241317794_798186691.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789289ENST00000318511420385_389186895.0Compositional biasNote=Poly-Lys
TgeneILF3chr19:10887892chr19:10789289ENST00000318511420634_637186895.0Compositional biasNote=Poly-Pro
TgeneILF3chr19:10887892chr19:10789289ENST00000318511420640_659186895.0Compositional biasNote=Arg/Gly-rich
TgeneILF3chr19:10887892chr19:10789289ENST00000318511420701_709186895.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789289ENST00000318511420794_798186895.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789289ENST00000407004418385_389186707.0Compositional biasNote=Poly-Lys
TgeneILF3chr19:10887892chr19:10789289ENST00000407004418634_637186707.0Compositional biasNote=Poly-Pro
TgeneILF3chr19:10887892chr19:10789289ENST00000407004418640_659186707.0Compositional biasNote=Arg/Gly-rich
TgeneILF3chr19:10887892chr19:10789289ENST00000407004418701_709186707.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789289ENST00000407004418794_798186707.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789289ENST00000420083418385_389186691.0Compositional biasNote=Poly-Lys
TgeneILF3chr19:10887892chr19:10789289ENST00000420083418634_637186691.0Compositional biasNote=Poly-Pro
TgeneILF3chr19:10887892chr19:10789289ENST00000420083418640_659186691.0Compositional biasNote=Arg/Gly-rich
TgeneILF3chr19:10887892chr19:10789289ENST00000420083418701_709186691.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789289ENST00000420083418794_798186691.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789289ENST00000449870420385_389186899.0Compositional biasNote=Poly-Lys
TgeneILF3chr19:10887892chr19:10789289ENST00000449870420634_637186899.0Compositional biasNote=Poly-Pro
TgeneILF3chr19:10887892chr19:10789289ENST00000449870420640_659186899.0Compositional biasNote=Arg/Gly-rich
TgeneILF3chr19:10887892chr19:10789289ENST00000449870420701_709186899.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789289ENST00000449870420794_798186899.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789289ENST00000588657319385_389186899.0Compositional biasNote=Poly-Lys
TgeneILF3chr19:10887892chr19:10789289ENST00000588657319634_637186899.0Compositional biasNote=Poly-Pro
TgeneILF3chr19:10887892chr19:10789289ENST00000588657319640_659186899.0Compositional biasNote=Arg/Gly-rich
TgeneILF3chr19:10887892chr19:10789289ENST00000588657319701_709186899.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789289ENST00000588657319794_798186899.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789289ENST00000589998418385_389186703.0Compositional biasNote=Poly-Lys
TgeneILF3chr19:10887892chr19:10789289ENST00000589998418634_637186703.0Compositional biasNote=Poly-Pro
TgeneILF3chr19:10887892chr19:10789289ENST00000589998418640_659186703.0Compositional biasNote=Arg/Gly-rich
TgeneILF3chr19:10887892chr19:10789289ENST00000589998418701_709186703.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789289ENST00000589998418794_798186703.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789289ENST00000590261319385_389186895.0Compositional biasNote=Poly-Lys
TgeneILF3chr19:10887892chr19:10789289ENST00000590261319634_637186895.0Compositional biasNote=Poly-Pro
TgeneILF3chr19:10887892chr19:10789289ENST00000590261319640_659186895.0Compositional biasNote=Arg/Gly-rich
TgeneILF3chr19:10887892chr19:10789289ENST00000590261319701_709186895.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789289ENST00000590261319794_798186895.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789289ENST00000592763316385_389186699.0Compositional biasNote=Poly-Lys
TgeneILF3chr19:10887892chr19:10789289ENST00000592763316634_637186699.0Compositional biasNote=Poly-Pro
TgeneILF3chr19:10887892chr19:10789289ENST00000592763316640_659186699.0Compositional biasNote=Arg/Gly-rich
TgeneILF3chr19:10887892chr19:10789289ENST00000592763316701_709186699.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789289ENST00000592763316794_798186699.0Compositional biasNote=Poly-Gly
TgeneILF3chr19:10887892chr19:10789288ENST00000250241317398_467186691.0DomainDRBM 1
TgeneILF3chr19:10887892chr19:10789288ENST00000250241317524_590186691.0DomainDRBM 2
TgeneILF3chr19:10887892chr19:10789288ENST00000318511420398_467186895.0DomainDRBM 1
TgeneILF3chr19:10887892chr19:10789288ENST00000318511420524_590186895.0DomainDRBM 2
TgeneILF3chr19:10887892chr19:10789288ENST00000407004418398_467186707.0DomainDRBM 1
TgeneILF3chr19:10887892chr19:10789288ENST00000407004418524_590186707.0DomainDRBM 2
TgeneILF3chr19:10887892chr19:10789288ENST00000420083418398_467186691.0DomainDRBM 1
TgeneILF3chr19:10887892chr19:10789288ENST00000420083418524_590186691.0DomainDRBM 2
TgeneILF3chr19:10887892chr19:10789288ENST00000449870420398_467186899.0DomainDRBM 1
TgeneILF3chr19:10887892chr19:10789288ENST00000449870420524_590186899.0DomainDRBM 2
TgeneILF3chr19:10887892chr19:10789288ENST00000588657319398_467186899.0DomainDRBM 1
TgeneILF3chr19:10887892chr19:10789288ENST00000588657319524_590186899.0DomainDRBM 2
TgeneILF3chr19:10887892chr19:10789288ENST00000589998418398_467186703.0DomainDRBM 1
TgeneILF3chr19:10887892chr19:10789288ENST00000589998418524_590186703.0DomainDRBM 2
TgeneILF3chr19:10887892chr19:10789288ENST00000590261319398_467186895.0DomainDRBM 1
TgeneILF3chr19:10887892chr19:10789288ENST00000590261319524_590186895.0DomainDRBM 2
TgeneILF3chr19:10887892chr19:10789288ENST00000592763316398_467186699.0DomainDRBM 1
TgeneILF3chr19:10887892chr19:10789288ENST00000592763316524_590186699.0DomainDRBM 2
TgeneILF3chr19:10887892chr19:10789289ENST00000250241317398_467186691.0DomainDRBM 1
TgeneILF3chr19:10887892chr19:10789289ENST00000250241317524_590186691.0DomainDRBM 2
TgeneILF3chr19:10887892chr19:10789289ENST00000318511420398_467186895.0DomainDRBM 1
TgeneILF3chr19:10887892chr19:10789289ENST00000318511420524_590186895.0DomainDRBM 2
TgeneILF3chr19:10887892chr19:10789289ENST00000407004418398_467186707.0DomainDRBM 1
TgeneILF3chr19:10887892chr19:10789289ENST00000407004418524_590186707.0DomainDRBM 2
TgeneILF3chr19:10887892chr19:10789289ENST00000420083418398_467186691.0DomainDRBM 1
TgeneILF3chr19:10887892chr19:10789289ENST00000420083418524_590186691.0DomainDRBM 2
TgeneILF3chr19:10887892chr19:10789289ENST00000449870420398_467186899.0DomainDRBM 1
TgeneILF3chr19:10887892chr19:10789289ENST00000449870420524_590186899.0DomainDRBM 2
TgeneILF3chr19:10887892chr19:10789289ENST00000588657319398_467186899.0DomainDRBM 1
TgeneILF3chr19:10887892chr19:10789289ENST00000588657319524_590186899.0DomainDRBM 2
TgeneILF3chr19:10887892chr19:10789289ENST00000589998418398_467186703.0DomainDRBM 1
TgeneILF3chr19:10887892chr19:10789289ENST00000589998418524_590186703.0DomainDRBM 2
TgeneILF3chr19:10887892chr19:10789289ENST00000590261319398_467186895.0DomainDRBM 1
TgeneILF3chr19:10887892chr19:10789289ENST00000590261319524_590186895.0DomainDRBM 2
TgeneILF3chr19:10887892chr19:10789289ENST00000592763316398_467186699.0DomainDRBM 1
TgeneILF3chr19:10887892chr19:10789289ENST00000592763316524_590186699.0DomainDRBM 2
TgeneILF3chr19:10887892chr19:10789288ENST00000250241317371_389186691.0MotifBipartite nuclear localization signal
TgeneILF3chr19:10887892chr19:10789288ENST00000318511420371_389186895.0MotifBipartite nuclear localization signal
TgeneILF3chr19:10887892chr19:10789288ENST00000407004418371_389186707.0MotifBipartite nuclear localization signal
TgeneILF3chr19:10887892chr19:10789288ENST00000420083418371_389186691.0MotifBipartite nuclear localization signal
TgeneILF3chr19:10887892chr19:10789288ENST00000449870420371_389186899.0MotifBipartite nuclear localization signal
TgeneILF3chr19:10887892chr19:10789288ENST00000588657319371_389186899.0MotifBipartite nuclear localization signal
TgeneILF3chr19:10887892chr19:10789288ENST00000589998418371_389186703.0MotifBipartite nuclear localization signal
TgeneILF3chr19:10887892chr19:10789288ENST00000590261319371_389186895.0MotifBipartite nuclear localization signal
TgeneILF3chr19:10887892chr19:10789288ENST00000592763316371_389186699.0MotifBipartite nuclear localization signal
TgeneILF3chr19:10887892chr19:10789289ENST00000250241317371_389186691.0MotifBipartite nuclear localization signal
TgeneILF3chr19:10887892chr19:10789289ENST00000318511420371_389186895.0MotifBipartite nuclear localization signal
TgeneILF3chr19:10887892chr19:10789289ENST00000407004418371_389186707.0MotifBipartite nuclear localization signal
TgeneILF3chr19:10887892chr19:10789289ENST00000420083418371_389186691.0MotifBipartite nuclear localization signal
TgeneILF3chr19:10887892chr19:10789289ENST00000449870420371_389186899.0MotifBipartite nuclear localization signal
TgeneILF3chr19:10887892chr19:10789289ENST00000588657319371_389186899.0MotifBipartite nuclear localization signal
TgeneILF3chr19:10887892chr19:10789289ENST00000589998418371_389186703.0MotifBipartite nuclear localization signal
TgeneILF3chr19:10887892chr19:10789289ENST00000590261319371_389186895.0MotifBipartite nuclear localization signal
TgeneILF3chr19:10887892chr19:10789289ENST00000592763316371_389186699.0MotifBipartite nuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM2chr19:10887892chr19:10789288ENST00000355667+521747_866229871.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10887892chr19:10789288ENST00000359692+520747_866229867.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10887892chr19:10789288ENST00000389253+521747_866229871.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10887892chr19:10789288ENST00000408974+520747_866229867.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10887892chr19:10789288ENST00000585892+521747_866229870.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10887892chr19:10789289ENST00000355667+521747_866229871.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10887892chr19:10789289ENST00000359692+520747_866229867.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10887892chr19:10789289ENST00000389253+521747_866229871.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10887892chr19:10789289ENST00000408974+520747_866229867.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10887892chr19:10789289ENST00000585892+521747_866229870.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10887892chr19:10789288ENST00000355667+52128_294229871.0DomainDynamin-type G
HgeneDNM2chr19:10887892chr19:10789288ENST00000355667+521519_625229871.0DomainPH
HgeneDNM2chr19:10887892chr19:10789288ENST00000355667+521653_744229871.0DomainGED
HgeneDNM2chr19:10887892chr19:10789288ENST00000359692+52028_294229867.0DomainDynamin-type G
HgeneDNM2chr19:10887892chr19:10789288ENST00000359692+520519_625229867.0DomainPH
HgeneDNM2chr19:10887892chr19:10789288ENST00000359692+520653_744229867.0DomainGED
HgeneDNM2chr19:10887892chr19:10789288ENST00000389253+52128_294229871.0DomainDynamin-type G
HgeneDNM2chr19:10887892chr19:10789288ENST00000389253+521519_625229871.0DomainPH
HgeneDNM2chr19:10887892chr19:10789288ENST00000389253+521653_744229871.0DomainGED
HgeneDNM2chr19:10887892chr19:10789288ENST00000408974+52028_294229867.0DomainDynamin-type G
HgeneDNM2chr19:10887892chr19:10789288ENST00000408974+520519_625229867.0DomainPH
HgeneDNM2chr19:10887892chr19:10789288ENST00000408974+520653_744229867.0DomainGED
HgeneDNM2chr19:10887892chr19:10789288ENST00000585892+52128_294229870.0DomainDynamin-type G
HgeneDNM2chr19:10887892chr19:10789288ENST00000585892+521519_625229870.0DomainPH
HgeneDNM2chr19:10887892chr19:10789288ENST00000585892+521653_744229870.0DomainGED
HgeneDNM2chr19:10887892chr19:10789289ENST00000355667+52128_294229871.0DomainDynamin-type G
HgeneDNM2chr19:10887892chr19:10789289ENST00000355667+521519_625229871.0DomainPH
HgeneDNM2chr19:10887892chr19:10789289ENST00000355667+521653_744229871.0DomainGED
HgeneDNM2chr19:10887892chr19:10789289ENST00000359692+52028_294229867.0DomainDynamin-type G
HgeneDNM2chr19:10887892chr19:10789289ENST00000359692+520519_625229867.0DomainPH
HgeneDNM2chr19:10887892chr19:10789289ENST00000359692+520653_744229867.0DomainGED
HgeneDNM2chr19:10887892chr19:10789289ENST00000389253+52128_294229871.0DomainDynamin-type G
HgeneDNM2chr19:10887892chr19:10789289ENST00000389253+521519_625229871.0DomainPH
HgeneDNM2chr19:10887892chr19:10789289ENST00000389253+521653_744229871.0DomainGED
HgeneDNM2chr19:10887892chr19:10789289ENST00000408974+52028_294229867.0DomainDynamin-type G
HgeneDNM2chr19:10887892chr19:10789289ENST00000408974+520519_625229867.0DomainPH
HgeneDNM2chr19:10887892chr19:10789289ENST00000408974+520653_744229867.0DomainGED
HgeneDNM2chr19:10887892chr19:10789289ENST00000585892+52128_294229870.0DomainDynamin-type G
HgeneDNM2chr19:10887892chr19:10789289ENST00000585892+521519_625229870.0DomainPH
HgeneDNM2chr19:10887892chr19:10789289ENST00000585892+521653_744229870.0DomainGED
HgeneDNM2chr19:10887892chr19:10789288ENST00000355667+521236_239229871.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789288ENST00000359692+520236_239229867.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789288ENST00000389253+521236_239229871.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789288ENST00000408974+520236_239229867.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789288ENST00000585892+521236_239229870.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789289ENST00000355667+521236_239229871.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789289ENST00000359692+520236_239229867.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789289ENST00000389253+521236_239229871.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789289ENST00000408974+520236_239229867.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789289ENST00000585892+521236_239229870.0Nucleotide bindingGTP
HgeneDNM2chr19:10887892chr19:10789288ENST00000355667+521235_238229871.0RegionG5 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000359692+520235_238229867.0RegionG5 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000389253+521235_238229871.0RegionG5 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000408974+520235_238229867.0RegionG5 motif
HgeneDNM2chr19:10887892chr19:10789288ENST00000585892+521235_238229870.0RegionG5 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000355667+521235_238229871.0RegionG5 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000359692+520235_238229867.0RegionG5 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000389253+521235_238229871.0RegionG5 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000408974+520235_238229867.0RegionG5 motif
HgeneDNM2chr19:10887892chr19:10789289ENST00000585892+521235_238229870.0RegionG5 motif
TgeneILF3chr19:10887892chr19:10789288ENST000002502413175_378186691.0DomainDZF
TgeneILF3chr19:10887892chr19:10789288ENST000003185114205_378186895.0DomainDZF
TgeneILF3chr19:10887892chr19:10789288ENST000004070044185_378186707.0DomainDZF
TgeneILF3chr19:10887892chr19:10789288ENST000004200834185_378186691.0DomainDZF
TgeneILF3chr19:10887892chr19:10789288ENST000004498704205_378186899.0DomainDZF
TgeneILF3chr19:10887892chr19:10789288ENST000005886573195_378186899.0DomainDZF
TgeneILF3chr19:10887892chr19:10789288ENST000005899984185_378186703.0DomainDZF
TgeneILF3chr19:10887892chr19:10789288ENST000005902613195_378186895.0DomainDZF
TgeneILF3chr19:10887892chr19:10789288ENST000005927633165_378186699.0DomainDZF
TgeneILF3chr19:10887892chr19:10789289ENST000002502413175_378186691.0DomainDZF
TgeneILF3chr19:10887892chr19:10789289ENST000003185114205_378186895.0DomainDZF
TgeneILF3chr19:10887892chr19:10789289ENST000004070044185_378186707.0DomainDZF
TgeneILF3chr19:10887892chr19:10789289ENST000004200834185_378186691.0DomainDZF
TgeneILF3chr19:10887892chr19:10789289ENST000004498704205_378186899.0DomainDZF
TgeneILF3chr19:10887892chr19:10789289ENST000005886573195_378186899.0DomainDZF
TgeneILF3chr19:10887892chr19:10789289ENST000005899984185_378186703.0DomainDZF
TgeneILF3chr19:10887892chr19:10789289ENST000005902613195_378186895.0DomainDZF
TgeneILF3chr19:10887892chr19:10789289ENST000005927633165_378186699.0DomainDZF


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Fusion Gene Sequence for DNM2-ILF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DNM2-ILF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneILF3chr19:10887892chr19:10789288ENST00000250241317609_894186.33333333333334691.0PRMT1
TgeneILF3chr19:10887892chr19:10789288ENST00000318511420609_894186.33333333333334895.0PRMT1
TgeneILF3chr19:10887892chr19:10789288ENST00000407004418609_894186.33333333333334707.0PRMT1
TgeneILF3chr19:10887892chr19:10789288ENST00000420083418609_894186.33333333333334691.0PRMT1
TgeneILF3chr19:10887892chr19:10789288ENST00000449870420609_894186.33333333333334899.0PRMT1
TgeneILF3chr19:10887892chr19:10789288ENST00000588657319609_894186.33333333333334899.0PRMT1
TgeneILF3chr19:10887892chr19:10789288ENST00000589998418609_894186.33333333333334703.0PRMT1
TgeneILF3chr19:10887892chr19:10789288ENST00000590261319609_894186.33333333333334895.0PRMT1
TgeneILF3chr19:10887892chr19:10789288ENST00000592763316609_894186.33333333333334699.0PRMT1
TgeneILF3chr19:10887892chr19:10789289ENST00000250241317609_894186.33333333333334691.0PRMT1
TgeneILF3chr19:10887892chr19:10789289ENST00000318511420609_894186.33333333333334895.0PRMT1
TgeneILF3chr19:10887892chr19:10789289ENST00000407004418609_894186.33333333333334707.0PRMT1
TgeneILF3chr19:10887892chr19:10789289ENST00000420083418609_894186.33333333333334691.0PRMT1
TgeneILF3chr19:10887892chr19:10789289ENST00000449870420609_894186.33333333333334899.0PRMT1
TgeneILF3chr19:10887892chr19:10789289ENST00000588657319609_894186.33333333333334899.0PRMT1
TgeneILF3chr19:10887892chr19:10789289ENST00000589998418609_894186.33333333333334703.0PRMT1
TgeneILF3chr19:10887892chr19:10789289ENST00000590261319609_894186.33333333333334895.0PRMT1
TgeneILF3chr19:10887892chr19:10789289ENST00000592763316609_894186.33333333333334699.0PRMT1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNM2-ILF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DNM2-ILF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNM2C4551952Myopathy, Centronuclear, 113CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneDNM2C1847902CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE B (disorder)8CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneDNM2C1834558Myopathy, Centronuclear, Autosomal Dominant7CLINGEN;CTD_human;ORPHANET
HgeneDNM2C0175709Centronuclear myopathy2CTD_human;GENOMICS_ENGLAND
HgeneDNM2C3809272LETHAL CONGENITAL CONTRACTURE SYNDROME 52CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneDNM2C0410203X-linked centronuclear myopathy1CTD_human
HgeneDNM2C0410207Tubular Aggregate Myopathy1CTD_human
HgeneDNM2C0546264Congenital Fiber Type Disproportion1CTD_human
HgeneDNM2C0752282Congenital Structural Myopathy1CTD_human
HgeneDNM2C3645536Autosomal Recessive Centronuclear Myopathy1CTD_human
HgeneDNM2C3661489Autosomal Dominant Myotubular Myopathy1CTD_human