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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNM2-P2RY11 (FusionGDB2 ID:HG1785TG5032)

Fusion Gene Summary for DNM2-P2RY11

check button Fusion gene summary
Fusion gene informationFusion gene name: DNM2-P2RY11
Fusion gene ID: hg1785tg5032
HgeneTgene
Gene symbol

DNM2

P2RY11

Gene ID

1785

5032

Gene namedynamin 2purinergic receptor P2Y11
SynonymsCMT2M|CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII|LCCS5P2Y11
Cytomap('DNM2')('P2RY11')

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptiondynamin-2dynamin IIP2Y purinoceptor 11purinergic receptor P2Y, G-protein coupled, 11
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000314646, ENST00000355667, 
ENST00000359692, ENST00000389253, 
ENST00000408974, ENST00000585892, 
ENST00000591819, 
Fusion gene scores* DoF score36 X 17 X 17=104042 X 2 X 1=4
# samples 492
** MAII scorelog2(49/10404*10)=-4.40821274494042
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: DNM2 [Title/Abstract] AND P2RY11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNM2(10913034)-P2RY11(10224309), # samples:2
Anticipated loss of major functional domain due to fusion event.DNM2-P2RY11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-P2RY11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-P2RY11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-P2RY11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNM2

GO:1903526

negative regulation of membrane tubulation

18388313

TgeneP2RY11

GO:0007186

G protein-coupled receptor signaling pathway

18048695

TgeneP2RY11

GO:0019722

calcium-mediated signaling

18048695

TgeneP2RY11

GO:0023041

neuronal signal transduction

18048695

TgeneP2RY11

GO:0071318

cellular response to ATP

18048695


check buttonFusion gene breakpoints across DNM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across P2RY11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A1JL-01ADNM2chr19

10913034

+P2RY11chr19

10224309

+


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Fusion Gene ORF analysis for DNM2-P2RY11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000314646ENST00000471843DNM2chr19

10913034

+P2RY11chr19

10224309

+
5CDS-3UTRENST00000355667ENST00000471843DNM2chr19

10913034

+P2RY11chr19

10224309

+
5CDS-3UTRENST00000359692ENST00000471843DNM2chr19

10913034

+P2RY11chr19

10224309

+
5CDS-3UTRENST00000389253ENST00000471843DNM2chr19

10913034

+P2RY11chr19

10224309

+
5CDS-3UTRENST00000408974ENST00000471843DNM2chr19

10913034

+P2RY11chr19

10224309

+
5CDS-3UTRENST00000585892ENST00000471843DNM2chr19

10913034

+P2RY11chr19

10224309

+
In-frameENST00000314646ENST00000321826DNM2chr19

10913034

+P2RY11chr19

10224309

+
In-frameENST00000355667ENST00000321826DNM2chr19

10913034

+P2RY11chr19

10224309

+
In-frameENST00000359692ENST00000321826DNM2chr19

10913034

+P2RY11chr19

10224309

+
In-frameENST00000389253ENST00000321826DNM2chr19

10913034

+P2RY11chr19

10224309

+
In-frameENST00000408974ENST00000321826DNM2chr19

10913034

+P2RY11chr19

10224309

+
In-frameENST00000585892ENST00000321826DNM2chr19

10913034

+P2RY11chr19

10224309

+
intron-3CDSENST00000591819ENST00000321826DNM2chr19

10913034

+P2RY11chr19

10224309

+
intron-3UTRENST00000591819ENST00000471843DNM2chr19

10913034

+P2RY11chr19

10224309

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000585892DNM2chr1910913034+ENST00000321826P2RY11chr1910224309+339716571641750528
ENST00000314646DNM2chr1910913034+ENST00000321826P2RY11chr1910224309+339716571641750528
ENST00000359692DNM2chr1910913034+ENST00000321826P2RY11chr1910224309+338316431501736528
ENST00000389253DNM2chr1910913034+ENST00000321826P2RY11chr1910224309+334516051121698528
ENST00000355667DNM2chr1910913034+ENST00000321826P2RY11chr1910224309+33131573801666528
ENST00000408974DNM2chr1910913034+ENST00000321826P2RY11chr1910224309+32681528351621528

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000585892ENST00000321826DNM2chr1910913034+P2RY11chr1910224309+0.0168991890.9831009
ENST00000314646ENST00000321826DNM2chr1910913034+P2RY11chr1910224309+0.0162992810.9837007
ENST00000359692ENST00000321826DNM2chr1910913034+P2RY11chr1910224309+0.0166717230.9833282
ENST00000389253ENST00000321826DNM2chr1910913034+P2RY11chr1910224309+0.0157028980.9842971
ENST00000355667ENST00000321826DNM2chr1910913034+P2RY11chr1910224309+0.016207250.9837928
ENST00000408974ENST00000321826DNM2chr1910913034+P2RY11chr1910224309+0.0162868390.98371315

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Fusion Genomic Features for DNM2-P2RY11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DNM2chr1910913034+P2RY11chr1910224308+1.79E-081
DNM2chr1910913034+P2RY11chr1910224308+1.79E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DNM2-P2RY11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:10913034/chr19:10224309)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM2chr19:10913034chr19:10224309ENST00000355667+122128_294497871.0DomainDynamin-type G
HgeneDNM2chr19:10913034chr19:10224309ENST00000359692+122028_294497867.0DomainDynamin-type G
HgeneDNM2chr19:10913034chr19:10224309ENST00000389253+122128_294497871.0DomainDynamin-type G
HgeneDNM2chr19:10913034chr19:10224309ENST00000408974+122028_294497867.0DomainDynamin-type G
HgeneDNM2chr19:10913034chr19:10224309ENST00000585892+122128_294497870.0DomainDynamin-type G
HgeneDNM2chr19:10913034chr19:10224309ENST00000355667+1221205_211497871.0Nucleotide bindingGTP
HgeneDNM2chr19:10913034chr19:10224309ENST00000355667+1221236_239497871.0Nucleotide bindingGTP
HgeneDNM2chr19:10913034chr19:10224309ENST00000355667+122138_46497871.0Nucleotide bindingGTP
HgeneDNM2chr19:10913034chr19:10224309ENST00000359692+1220205_211497867.0Nucleotide bindingGTP
HgeneDNM2chr19:10913034chr19:10224309ENST00000359692+1220236_239497867.0Nucleotide bindingGTP
HgeneDNM2chr19:10913034chr19:10224309ENST00000359692+122038_46497867.0Nucleotide bindingGTP
HgeneDNM2chr19:10913034chr19:10224309ENST00000389253+1221205_211497871.0Nucleotide bindingGTP
HgeneDNM2chr19:10913034chr19:10224309ENST00000389253+1221236_239497871.0Nucleotide bindingGTP
HgeneDNM2chr19:10913034chr19:10224309ENST00000389253+122138_46497871.0Nucleotide bindingGTP
HgeneDNM2chr19:10913034chr19:10224309ENST00000408974+1220205_211497867.0Nucleotide bindingGTP
HgeneDNM2chr19:10913034chr19:10224309ENST00000408974+1220236_239497867.0Nucleotide bindingGTP
HgeneDNM2chr19:10913034chr19:10224309ENST00000408974+122038_46497867.0Nucleotide bindingGTP
HgeneDNM2chr19:10913034chr19:10224309ENST00000585892+1221205_211497870.0Nucleotide bindingGTP
HgeneDNM2chr19:10913034chr19:10224309ENST00000585892+1221236_239497870.0Nucleotide bindingGTP
HgeneDNM2chr19:10913034chr19:10224309ENST00000585892+122138_46497870.0Nucleotide bindingGTP
HgeneDNM2chr19:10913034chr19:10224309ENST00000355667+1221136_139497871.0RegionG3 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000355667+1221205_208497871.0RegionG4 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000355667+1221235_238497871.0RegionG5 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000355667+122138_45497871.0RegionG1 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000355667+122164_66497871.0RegionG2 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000359692+1220136_139497867.0RegionG3 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000359692+1220205_208497867.0RegionG4 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000359692+1220235_238497867.0RegionG5 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000359692+122038_45497867.0RegionG1 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000359692+122064_66497867.0RegionG2 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000389253+1221136_139497871.0RegionG3 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000389253+1221205_208497871.0RegionG4 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000389253+1221235_238497871.0RegionG5 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000389253+122138_45497871.0RegionG1 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000389253+122164_66497871.0RegionG2 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000408974+1220136_139497867.0RegionG3 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000408974+1220205_208497867.0RegionG4 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000408974+1220235_238497867.0RegionG5 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000408974+122038_45497867.0RegionG1 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000408974+122064_66497867.0RegionG2 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000585892+1221136_139497870.0RegionG3 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000585892+1221205_208497870.0RegionG4 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000585892+1221235_238497870.0RegionG5 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000585892+122138_45497870.0RegionG1 motif
HgeneDNM2chr19:10913034chr19:10224309ENST00000585892+122164_66497870.0RegionG2 motif
TgeneP2RY11chr19:10913034chr19:10224309ENST0000032182602138_1466375.0Topological domainCytoplasmic
TgeneP2RY11chr19:10913034chr19:10224309ENST0000032182602168_2066375.0Topological domainExtracellular
TgeneP2RY11chr19:10913034chr19:10224309ENST0000032182602228_2456375.0Topological domainCytoplasmic
TgeneP2RY11chr19:10913034chr19:10224309ENST0000032182602267_3086375.0Topological domainExtracellular
TgeneP2RY11chr19:10913034chr19:10224309ENST0000032182602330_3746375.0Topological domainCytoplasmic
TgeneP2RY11chr19:10913034chr19:10224309ENST000003218260251_646375.0Topological domainCytoplasmic
TgeneP2RY11chr19:10913034chr19:10224309ENST000003218260286_1166375.0Topological domainExtracellular
TgeneP2RY11chr19:10913034chr19:10224309ENST0000032182602117_1376375.0TransmembraneHelical%3B Name%3D3
TgeneP2RY11chr19:10913034chr19:10224309ENST0000032182602147_1676375.0TransmembraneHelical%3B Name%3D4
TgeneP2RY11chr19:10913034chr19:10224309ENST0000032182602207_2276375.0TransmembraneHelical%3B Name%3D5
TgeneP2RY11chr19:10913034chr19:10224309ENST0000032182602246_2666375.0TransmembraneHelical%3B Name%3D6
TgeneP2RY11chr19:10913034chr19:10224309ENST0000032182602309_3296375.0TransmembraneHelical%3B Name%3D7
TgeneP2RY11chr19:10913034chr19:10224309ENST000003218260230_506375.0TransmembraneHelical%3B Name%3D1
TgeneP2RY11chr19:10913034chr19:10224309ENST000003218260265_856375.0TransmembraneHelical%3B Name%3D2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM2chr19:10913034chr19:10224309ENST00000355667+1221747_866497871.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10913034chr19:10224309ENST00000359692+1220747_866497867.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10913034chr19:10224309ENST00000389253+1221747_866497871.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10913034chr19:10224309ENST00000408974+1220747_866497867.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10913034chr19:10224309ENST00000585892+1221747_866497870.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10913034chr19:10224309ENST00000355667+1221519_625497871.0DomainPH
HgeneDNM2chr19:10913034chr19:10224309ENST00000355667+1221653_744497871.0DomainGED
HgeneDNM2chr19:10913034chr19:10224309ENST00000359692+1220519_625497867.0DomainPH
HgeneDNM2chr19:10913034chr19:10224309ENST00000359692+1220653_744497867.0DomainGED
HgeneDNM2chr19:10913034chr19:10224309ENST00000389253+1221519_625497871.0DomainPH
HgeneDNM2chr19:10913034chr19:10224309ENST00000389253+1221653_744497871.0DomainGED
HgeneDNM2chr19:10913034chr19:10224309ENST00000408974+1220519_625497867.0DomainPH
HgeneDNM2chr19:10913034chr19:10224309ENST00000408974+1220653_744497867.0DomainGED
HgeneDNM2chr19:10913034chr19:10224309ENST00000585892+1221519_625497870.0DomainPH
HgeneDNM2chr19:10913034chr19:10224309ENST00000585892+1221653_744497870.0DomainGED
TgeneP2RY11chr19:10913034chr19:10224309ENST00000321826021_296375.0Topological domainExtracellular


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Fusion Gene Sequence for DNM2-P2RY11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23648_23648_1_DNM2-P2RY11_DNM2_chr19_10913034_ENST00000314646_P2RY11_chr19_10224309_ENST00000321826_length(transcript)=3397nt_BP=1657nt
GAGAACCGGATGAGGCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACG
CCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGA
TGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTG
TAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGGACTTCCTTCCCCGCGGTTCAGGAATCGTCACCC
GGCGGCCTCTCATTCTGCAGCTCATCTTCTCAAAAACAGAACATGCCGAGTTTTTGCACTGCAAGTCCAAAAAGTTTACAGACTTTGATG
AAGTCCGGCAGGAGATTGAAGCAGAGACCGACAGGGTCACGGGGACCAACAAAGGCATCTCCCCAGTGCCCATCAACCTTCGAGTCTACT
CGCCACACGTGTTGAACTTGACCCTCATCGACCTCCCGGGTATCACCAAGGTGCCTGTGGGCGACCAGCCTCCAGACATCGAGTACCAGA
TCAAGGACATGATCCTGCAGTTCATCAGCCGGGAGAGCAGCCTCATTCTGGCTGTCACGCCCGCCAACATGGACCTGGCCAACTCCGACG
CCCTCAAGCTGGCCAAGGAAGTCGATCCCCAAGGCCTACGGACCATCGGTGTCATCACCAAGCTTGACCTGATGGACGAGGGCACCGACG
CCAGGGACGTCTTGGAGAACAAGTTGCTCCCGTTGAGAAGAGGCTACATTGGCGTGGTGAACCGCAGCCAGAAGGATATTGAGGGCAAGA
AGGACATCCGTGCAGCACTGGCAGCTGAGAGGAAGTTCTTCCTCTCCCACCCGGCCTACCGGCACATGGCCGACCGCATGGGCACGCCAC
ATCTGCAGAAGACGCTGAATCAGCAACTGACCAACCACATCCGGGAGTCGCTGCCGGCCCTACGTAGCAAACTACAGAGCCAGCTGCTGT
CCCTGGAGAAGGAGGTGGAGGAGTACAAGAACTTTCGGCCCGACGACCCCACCCGCAAAACCAAAGCCCTGCTGCAGATGGTCCAGCAGT
TTGGGGTGGATTTTGAGAAGAGGATCGAGGGCTCAGGAGATCAGGTGGACACTCTGGAGCTCTCCGGGGGCGCCCGAATCAATCGCATCT
TCCACGAGCGGTTCCCATTTGAGCTGGTGAAGATGGAGTTTGACGAGAAGGACTTACGACGGGAGATCAGCTATGCCATTAAGAACATCC
ATGGAGTCAGGACGGGGCTCTTCACCCCCGACATGGCCTTTGAAGCCATTGTGAAAAAACAGATTGTAAAACTCAAAGAGCCGAGTTTGA
AGTGTGTTGATCTCGTGGTCTCAGAGCTGGCCACGGTCATAAAAAAGTGTGCCGAGAAGCTCAGTTCCTACCCCCGGTTGCGAGAGGAGA
CAGAGCGAATCGTCACCACTTACATCCGGGAACGGGAGGGGAGAACGAAGGACCAGATTCTTCTGCTGATCGACATTGAGCAGTCCTACA
TCAACACGAACCATGAGGACTTCATCGGGTTTGCCAAGTGCCAAGTCCTGCCCTGCCAACTTCTTGGCAGCTGCCGACGACAAACTCAGT
GGGTTCCAGGGGGACTTCCTGTGGCCCATACTGGTGGTTGAGTTCCTGGTGGCCGTGGCCAGCAATGGCCTGGCCCTGTACCGCTTCAGC
ATCCGGAAGCAGCGCCCATGGCACCCCGCCGTGGTCTTCTCTGTCCAGCTGGCAGTCAGCGACCTGCTCTGCGCCCTGACGCTGCCCCCG
CTGGCCGCCTACCTCTATCCCCCCAAGCACTGGCGCTATGGGGAGGCCGCGTGCCGCCTGGAGCGCTTCCTCTTCACCTGCAACCTGCTG
GGCAGCGTCATCTTCATCACCTGCATCAGCCTCAACCGCTACCTGGGCATCGTGCACCCCTTCTTCGCCCGAAGCCACCTGCGACCCAAG
CACGCCTGGGCCGTGAGCGCTGCCGGCTGGGTCCTGGCCGCCCTGCTGGCCATGCCCACACTCAGCTTCTCCCACCTGAAGAGGCCGCAG
CAGGGGGCGGGCAACTGCAGCGTGGCCAGGCCCGAGGCCTGCATCAAGTGTCTGGGGACAGCAGACCACGGGCTGGCGGCCTACAGAGCG
TATAGCCTGGTGCTGGCGGGGTTGGGCTGCGGCCTGCCGCTGCTGCTCACGCTGGCAGCCTACGGCGCCCTCGGGCGGGCCGTGCTACGC
AGCCCAGGCATGACTGTGGCCGAGAAGCTGCGTGTGGCAGCGTTGGTGGCCAGTGGTGTGGCCCTCTACGCCAGCTCCTATGTGCCCTAC
CACATCATGCGGGTGCTCAACGTGGATGCTCGGCGGCGCTGGAGCACCCGCTGCCCGAGCTTTGCAGACATAGCCCAGGCCACAGCAGCC
CTGGAGCTGGGGCCCTACGTGGGCTACCAGGTGATGCGGGGCCTCATGCCCCTGGCCTTCTGTGTCCACCCTCTACTCTACATGGCCGCA
GTGCCCAGCCTGGGCTGCTGCTGCCGACACTGCCCCGGCTACAGGGACAGCTGGAACCCAGAGGACGCCAAGAGCACTGGCCAAGCCCTG
CCCCTCAATGCCACAGCCGCCCCTAAACCGTCAGAGCCCCAGTCCCGTGAGCTGAGCCAATGATGTGGCCTAGCGGAAGCTGCCTCCTCA
CCCTAGGTGTTGCTGGAGAACCCTGAGGGCAGGGCCCGAGCCCCGACACATCCCTTCCCCCAAAAAGCAACACCTGTGCTTGCAGCCAGG
TCAGGCCCAGCTGCAGCCCAGGCAGGAGCAGTCGCCTTTCCCACCCACAGCGCTGGCCACAGGGCTCCCTGCAGGGTCAGGGACCAGACC
ACGCCCAGAGGAGGGGAGGCACTGGCCCCCGCCACAGGACTGGAGACGCAAGAACAAAAAGAACCAAGTAGAGAGAGTGGAGCTGCTTTA
TTGCCCTTGGAGCCCGCGCTCTCGGAGGCTGTCTTCTGTCGCCAAGGGTCCCGGACCGAGTACACAGTGGCAGCTGGCTTAGTTGGTGGA
CGGCCTGGGGTAGGGGAGGGTGGCAGGTATAAGACTTCTGGGGGCACCCCAAGACCCCAGACACCCAAGTGGCATCTTGGGGGTGGGTGG
GCAGAGGACGGGGTAATGTGAGGACGAAGCGGGCACGGAGCCAGATGGCCAGTCTCCAGGCCTGGTCCACGGACTGGCAGGGACCCCAGG
CACAAGAGCTGCCACCCCTCTGCCCGGTTTTGGAAAAAAACAATAAAGGACTGTCCCCTCAAAACCA

>23648_23648_1_DNM2-P2RY11_DNM2_chr19_10913034_ENST00000314646_P2RY11_chr19_10224309_ENST00000321826_length(amino acids)=528AA_BP=498
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQIVKLKEPSLKCVDLVVSELATVIKKCAEKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFAKCQVLPCQLLGSCRRQTQWVPGGLPVAHTGG

--------------------------------------------------------------
>23648_23648_2_DNM2-P2RY11_DNM2_chr19_10913034_ENST00000355667_P2RY11_chr19_10224309_ENST00000321826_length(transcript)=3313nt_BP=1573nt
CAGACGCCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACC
GCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGA
TCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGGACTTCCTTCCCCGCGGTTCAGGAATCG
TCACCCGGCGGCCTCTCATTCTGCAGCTCATCTTCTCAAAAACAGAACATGCCGAGTTTTTGCACTGCAAGTCCAAAAAGTTTACAGACT
TTGATGAAGTCCGGCAGGAGATTGAAGCAGAGACCGACAGGGTCACGGGGACCAACAAAGGCATCTCCCCAGTGCCCATCAACCTTCGAG
TCTACTCGCCACACGTGTTGAACTTGACCCTCATCGACCTCCCGGGTATCACCAAGGTGCCTGTGGGCGACCAGCCTCCAGACATCGAGT
ACCAGATCAAGGACATGATCCTGCAGTTCATCAGCCGGGAGAGCAGCCTCATTCTGGCTGTCACGCCCGCCAACATGGACCTGGCCAACT
CCGACGCCCTCAAGCTGGCCAAGGAAGTCGATCCCCAAGGCCTACGGACCATCGGTGTCATCACCAAGCTTGACCTGATGGACGAGGGCA
CCGACGCCAGGGACGTCTTGGAGAACAAGTTGCTCCCGTTGAGAAGAGGCTACATTGGCGTGGTGAACCGCAGCCAGAAGGATATTGAGG
GCAAGAAGGACATCCGTGCAGCACTGGCAGCTGAGAGGAAGTTCTTCCTCTCCCACCCGGCCTACCGGCACATGGCCGACCGCATGGGCA
CGCCACATCTGCAGAAGACGCTGAATCAGCAACTGACCAACCACATCCGGGAGTCGCTGCCGGCCCTACGTAGCAAACTACAGAGCCAGC
TGCTGTCCCTGGAGAAGGAGGTGGAGGAGTACAAGAACTTTCGGCCCGACGACCCCACCCGCAAAACCAAAGCCCTGCTGCAGATGGTCC
AGCAGTTTGGGGTGGATTTTGAGAAGAGGATCGAGGGCTCAGGAGATCAGGTGGACACTCTGGAGCTCTCCGGGGGCGCCCGAATCAATC
GCATCTTCCACGAGCGGTTCCCATTTGAGCTGGTGAAGATGGAGTTTGACGAGAAGGACTTACGACGGGAGATCAGCTATGCCATTAAGA
ACATCCATGGAGTCAGGACCGGGCTTTTCACCCCGGACTTGGCATTCGAGGCCATTGTGAAAAAGCAGGTCGTCAAGCTGAAAGAGCCCT
GTCTGAAATGTGTCGACCTGGTTATCCAGGAGCTAATCAATACAGTTAGGCAGTGTACCAGTAAGCTCAGTTCCTACCCCCGGTTGCGAG
AGGAGACAGAGCGAATCGTCACCACTTACATCCGGGAACGGGAGGGGAGAACGAAGGACCAGATTCTTCTGCTGATCGACATTGAGCAGT
CCTACATCAACACGAACCATGAGGACTTCATCGGGTTTGCCAAGTGCCAAGTCCTGCCCTGCCAACTTCTTGGCAGCTGCCGACGACAAA
CTCAGTGGGTTCCAGGGGGACTTCCTGTGGCCCATACTGGTGGTTGAGTTCCTGGTGGCCGTGGCCAGCAATGGCCTGGCCCTGTACCGC
TTCAGCATCCGGAAGCAGCGCCCATGGCACCCCGCCGTGGTCTTCTCTGTCCAGCTGGCAGTCAGCGACCTGCTCTGCGCCCTGACGCTG
CCCCCGCTGGCCGCCTACCTCTATCCCCCCAAGCACTGGCGCTATGGGGAGGCCGCGTGCCGCCTGGAGCGCTTCCTCTTCACCTGCAAC
CTGCTGGGCAGCGTCATCTTCATCACCTGCATCAGCCTCAACCGCTACCTGGGCATCGTGCACCCCTTCTTCGCCCGAAGCCACCTGCGA
CCCAAGCACGCCTGGGCCGTGAGCGCTGCCGGCTGGGTCCTGGCCGCCCTGCTGGCCATGCCCACACTCAGCTTCTCCCACCTGAAGAGG
CCGCAGCAGGGGGCGGGCAACTGCAGCGTGGCCAGGCCCGAGGCCTGCATCAAGTGTCTGGGGACAGCAGACCACGGGCTGGCGGCCTAC
AGAGCGTATAGCCTGGTGCTGGCGGGGTTGGGCTGCGGCCTGCCGCTGCTGCTCACGCTGGCAGCCTACGGCGCCCTCGGGCGGGCCGTG
CTACGCAGCCCAGGCATGACTGTGGCCGAGAAGCTGCGTGTGGCAGCGTTGGTGGCCAGTGGTGTGGCCCTCTACGCCAGCTCCTATGTG
CCCTACCACATCATGCGGGTGCTCAACGTGGATGCTCGGCGGCGCTGGAGCACCCGCTGCCCGAGCTTTGCAGACATAGCCCAGGCCACA
GCAGCCCTGGAGCTGGGGCCCTACGTGGGCTACCAGGTGATGCGGGGCCTCATGCCCCTGGCCTTCTGTGTCCACCCTCTACTCTACATG
GCCGCAGTGCCCAGCCTGGGCTGCTGCTGCCGACACTGCCCCGGCTACAGGGACAGCTGGAACCCAGAGGACGCCAAGAGCACTGGCCAA
GCCCTGCCCCTCAATGCCACAGCCGCCCCTAAACCGTCAGAGCCCCAGTCCCGTGAGCTGAGCCAATGATGTGGCCTAGCGGAAGCTGCC
TCCTCACCCTAGGTGTTGCTGGAGAACCCTGAGGGCAGGGCCCGAGCCCCGACACATCCCTTCCCCCAAAAAGCAACACCTGTGCTTGCA
GCCAGGTCAGGCCCAGCTGCAGCCCAGGCAGGAGCAGTCGCCTTTCCCACCCACAGCGCTGGCCACAGGGCTCCCTGCAGGGTCAGGGAC
CAGACCACGCCCAGAGGAGGGGAGGCACTGGCCCCCGCCACAGGACTGGAGACGCAAGAACAAAAAGAACCAAGTAGAGAGAGTGGAGCT
GCTTTATTGCCCTTGGAGCCCGCGCTCTCGGAGGCTGTCTTCTGTCGCCAAGGGTCCCGGACCGAGTACACAGTGGCAGCTGGCTTAGTT
GGTGGACGGCCTGGGGTAGGGGAGGGTGGCAGGTATAAGACTTCTGGGGGCACCCCAAGACCCCAGACACCCAAGTGGCATCTTGGGGGT
GGGTGGGCAGAGGACGGGGTAATGTGAGGACGAAGCGGGCACGGAGCCAGATGGCCAGTCTCCAGGCCTGGTCCACGGACTGGCAGGGAC
CCCAGGCACAAGAGCTGCCACCCCTCTGCCCGGTTTTGGAAAAAAACAATAAAGGACTGTCCCCTCAAAACCA

>23648_23648_2_DNM2-P2RY11_DNM2_chr19_10913034_ENST00000355667_P2RY11_chr19_10224309_ENST00000321826_length(amino acids)=528AA_BP=498
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFAKCQVLPCQLLGSCRRQTQWVPGGLPVAHTGG

--------------------------------------------------------------
>23648_23648_3_DNM2-P2RY11_DNM2_chr19_10913034_ENST00000359692_P2RY11_chr19_10224309_ENST00000321826_length(transcript)=3383nt_BP=1643nt
GCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACGCCGCGGGGCCAGGT
CGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATC
CCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAG
AGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGGACTTCCTTCCCCGCGGTTCAGGAATCGTCACCCGGCGGCCTCTCATT
CTGCAGCTCATCTTCTCAAAAACAGAACATGCCGAGTTTTTGCACTGCAAGTCCAAAAAGTTTACAGACTTTGATGAAGTCCGGCAGGAG
ATTGAAGCAGAGACCGACAGGGTCACGGGGACCAACAAAGGCATCTCCCCAGTGCCCATCAACCTTCGAGTCTACTCGCCACACGTGTTG
AACTTGACCCTCATCGACCTCCCGGGTATCACCAAGGTGCCTGTGGGCGACCAGCCTCCAGACATCGAGTACCAGATCAAGGACATGATC
CTGCAGTTCATCAGCCGGGAGAGCAGCCTCATTCTGGCTGTCACGCCCGCCAACATGGACCTGGCCAACTCCGACGCCCTCAAGCTGGCC
AAGGAAGTCGATCCCCAAGGCCTACGGACCATCGGTGTCATCACCAAGCTTGACCTGATGGACGAGGGCACCGACGCCAGGGACGTCTTG
GAGAACAAGTTGCTCCCGTTGAGAAGAGGCTACATTGGCGTGGTGAACCGCAGCCAGAAGGATATTGAGGGCAAGAAGGACATCCGTGCA
GCACTGGCAGCTGAGAGGAAGTTCTTCCTCTCCCACCCGGCCTACCGGCACATGGCCGACCGCATGGGCACGCCACATCTGCAGAAGACG
CTGAATCAGCAACTGACCAACCACATCCGGGAGTCGCTGCCGGCCCTACGTAGCAAACTACAGAGCCAGCTGCTGTCCCTGGAGAAGGAG
GTGGAGGAGTACAAGAACTTTCGGCCCGACGACCCCACCCGCAAAACCAAAGCCCTGCTGCAGATGGTCCAGCAGTTTGGGGTGGATTTT
GAGAAGAGGATCGAGGGCTCAGGAGATCAGGTGGACACTCTGGAGCTCTCCGGGGGCGCCCGAATCAATCGCATCTTCCACGAGCGGTTC
CCATTTGAGCTGGTGAAGATGGAGTTTGACGAGAAGGACTTACGACGGGAGATCAGCTATGCCATTAAGAACATCCATGGAGTCAGGACC
GGGCTTTTCACCCCGGACTTGGCATTCGAGGCCATTGTGAAAAAGCAGGTCGTCAAGCTGAAAGAGCCCTGTCTGAAATGTGTCGACCTG
GTTATCCAGGAGCTAATCAATACAGTTAGGCAGTGTACCAGTAAGCTCAGTTCCTACCCCCGGTTGCGAGAGGAGACAGAGCGAATCGTC
ACCACTTACATCCGGGAACGGGAGGGGAGAACGAAGGACCAGATTCTTCTGCTGATCGACATTGAGCAGTCCTACATCAACACGAACCAT
GAGGACTTCATCGGGTTTGCCAAGTGCCAAGTCCTGCCCTGCCAACTTCTTGGCAGCTGCCGACGACAAACTCAGTGGGTTCCAGGGGGA
CTTCCTGTGGCCCATACTGGTGGTTGAGTTCCTGGTGGCCGTGGCCAGCAATGGCCTGGCCCTGTACCGCTTCAGCATCCGGAAGCAGCG
CCCATGGCACCCCGCCGTGGTCTTCTCTGTCCAGCTGGCAGTCAGCGACCTGCTCTGCGCCCTGACGCTGCCCCCGCTGGCCGCCTACCT
CTATCCCCCCAAGCACTGGCGCTATGGGGAGGCCGCGTGCCGCCTGGAGCGCTTCCTCTTCACCTGCAACCTGCTGGGCAGCGTCATCTT
CATCACCTGCATCAGCCTCAACCGCTACCTGGGCATCGTGCACCCCTTCTTCGCCCGAAGCCACCTGCGACCCAAGCACGCCTGGGCCGT
GAGCGCTGCCGGCTGGGTCCTGGCCGCCCTGCTGGCCATGCCCACACTCAGCTTCTCCCACCTGAAGAGGCCGCAGCAGGGGGCGGGCAA
CTGCAGCGTGGCCAGGCCCGAGGCCTGCATCAAGTGTCTGGGGACAGCAGACCACGGGCTGGCGGCCTACAGAGCGTATAGCCTGGTGCT
GGCGGGGTTGGGCTGCGGCCTGCCGCTGCTGCTCACGCTGGCAGCCTACGGCGCCCTCGGGCGGGCCGTGCTACGCAGCCCAGGCATGAC
TGTGGCCGAGAAGCTGCGTGTGGCAGCGTTGGTGGCCAGTGGTGTGGCCCTCTACGCCAGCTCCTATGTGCCCTACCACATCATGCGGGT
GCTCAACGTGGATGCTCGGCGGCGCTGGAGCACCCGCTGCCCGAGCTTTGCAGACATAGCCCAGGCCACAGCAGCCCTGGAGCTGGGGCC
CTACGTGGGCTACCAGGTGATGCGGGGCCTCATGCCCCTGGCCTTCTGTGTCCACCCTCTACTCTACATGGCCGCAGTGCCCAGCCTGGG
CTGCTGCTGCCGACACTGCCCCGGCTACAGGGACAGCTGGAACCCAGAGGACGCCAAGAGCACTGGCCAAGCCCTGCCCCTCAATGCCAC
AGCCGCCCCTAAACCGTCAGAGCCCCAGTCCCGTGAGCTGAGCCAATGATGTGGCCTAGCGGAAGCTGCCTCCTCACCCTAGGTGTTGCT
GGAGAACCCTGAGGGCAGGGCCCGAGCCCCGACACATCCCTTCCCCCAAAAAGCAACACCTGTGCTTGCAGCCAGGTCAGGCCCAGCTGC
AGCCCAGGCAGGAGCAGTCGCCTTTCCCACCCACAGCGCTGGCCACAGGGCTCCCTGCAGGGTCAGGGACCAGACCACGCCCAGAGGAGG
GGAGGCACTGGCCCCCGCCACAGGACTGGAGACGCAAGAACAAAAAGAACCAAGTAGAGAGAGTGGAGCTGCTTTATTGCCCTTGGAGCC
CGCGCTCTCGGAGGCTGTCTTCTGTCGCCAAGGGTCCCGGACCGAGTACACAGTGGCAGCTGGCTTAGTTGGTGGACGGCCTGGGGTAGG
GGAGGGTGGCAGGTATAAGACTTCTGGGGGCACCCCAAGACCCCAGACACCCAAGTGGCATCTTGGGGGTGGGTGGGCAGAGGACGGGGT
AATGTGAGGACGAAGCGGGCACGGAGCCAGATGGCCAGTCTCCAGGCCTGGTCCACGGACTGGCAGGGACCCCAGGCACAAGAGCTGCCA
CCCCTCTGCCCGGTTTTGGAAAAAAACAATAAAGGACTGTCCCCTCAAAACCA

>23648_23648_3_DNM2-P2RY11_DNM2_chr19_10913034_ENST00000359692_P2RY11_chr19_10224309_ENST00000321826_length(amino acids)=528AA_BP=498
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFAKCQVLPCQLLGSCRRQTQWVPGGLPVAHTGG

--------------------------------------------------------------
>23648_23648_4_DNM2-P2RY11_DNM2_chr19_10913034_ENST00000389253_P2RY11_chr19_10224309_ENST00000321826_length(transcript)=3345nt_BP=1605nt
CCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACGCCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCT
CGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCAT
CGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGG
CCGGGACTTCCTTCCCCGCGGTTCAGGAATCGTCACCCGGCGGCCTCTCATTCTGCAGCTCATCTTCTCAAAAACAGAACATGCCGAGTT
TTTGCACTGCAAGTCCAAAAAGTTTACAGACTTTGATGAAGTCCGGCAGGAGATTGAAGCAGAGACCGACAGGGTCACGGGGACCAACAA
AGGCATCTCCCCAGTGCCCATCAACCTTCGAGTCTACTCGCCACACGTGTTGAACTTGACCCTCATCGACCTCCCGGGTATCACCAAGGT
GCCTGTGGGCGACCAGCCTCCAGACATCGAGTACCAGATCAAGGACATGATCCTGCAGTTCATCAGCCGGGAGAGCAGCCTCATTCTGGC
TGTCACGCCCGCCAACATGGACCTGGCCAACTCCGACGCCCTCAAGCTGGCCAAGGAAGTCGATCCCCAAGGCCTACGGACCATCGGTGT
CATCACCAAGCTTGACCTGATGGACGAGGGCACCGACGCCAGGGACGTCTTGGAGAACAAGTTGCTCCCGTTGAGAAGAGGCTACATTGG
CGTGGTGAACCGCAGCCAGAAGGATATTGAGGGCAAGAAGGACATCCGTGCAGCACTGGCAGCTGAGAGGAAGTTCTTCCTCTCCCACCC
GGCCTACCGGCACATGGCCGACCGCATGGGCACGCCACATCTGCAGAAGACGCTGAATCAGCAACTGACCAACCACATCCGGGAGTCGCT
GCCGGCCCTACGTAGCAAACTACAGAGCCAGCTGCTGTCCCTGGAGAAGGAGGTGGAGGAGTACAAGAACTTTCGGCCCGACGACCCCAC
CCGCAAAACCAAAGCCCTGCTGCAGATGGTCCAGCAGTTTGGGGTGGATTTTGAGAAGAGGATCGAGGGCTCAGGAGATCAGGTGGACAC
TCTGGAGCTCTCCGGGGGCGCCCGAATCAATCGCATCTTCCACGAGCGGTTCCCATTTGAGCTGGTGAAGATGGAGTTTGACGAGAAGGA
CTTACGACGGGAGATCAGCTATGCCATTAAGAACATCCATGGAGTCAGGACGGGGCTCTTCACCCCCGACATGGCCTTTGAAGCCATTGT
GAAAAAACAGATTGTAAAACTCAAAGAGCCGAGTTTGAAGTGTGTTGATCTCGTGGTCTCAGAGCTGGCCACGGTCATAAAAAAGTGTGC
CGAGAAGCTCAGTTCCTACCCCCGGTTGCGAGAGGAGACAGAGCGAATCGTCACCACTTACATCCGGGAACGGGAGGGGAGAACGAAGGA
CCAGATTCTTCTGCTGATCGACATTGAGCAGTCCTACATCAACACGAACCATGAGGACTTCATCGGGTTTGCCAAGTGCCAAGTCCTGCC
CTGCCAACTTCTTGGCAGCTGCCGACGACAAACTCAGTGGGTTCCAGGGGGACTTCCTGTGGCCCATACTGGTGGTTGAGTTCCTGGTGG
CCGTGGCCAGCAATGGCCTGGCCCTGTACCGCTTCAGCATCCGGAAGCAGCGCCCATGGCACCCCGCCGTGGTCTTCTCTGTCCAGCTGG
CAGTCAGCGACCTGCTCTGCGCCCTGACGCTGCCCCCGCTGGCCGCCTACCTCTATCCCCCCAAGCACTGGCGCTATGGGGAGGCCGCGT
GCCGCCTGGAGCGCTTCCTCTTCACCTGCAACCTGCTGGGCAGCGTCATCTTCATCACCTGCATCAGCCTCAACCGCTACCTGGGCATCG
TGCACCCCTTCTTCGCCCGAAGCCACCTGCGACCCAAGCACGCCTGGGCCGTGAGCGCTGCCGGCTGGGTCCTGGCCGCCCTGCTGGCCA
TGCCCACACTCAGCTTCTCCCACCTGAAGAGGCCGCAGCAGGGGGCGGGCAACTGCAGCGTGGCCAGGCCCGAGGCCTGCATCAAGTGTC
TGGGGACAGCAGACCACGGGCTGGCGGCCTACAGAGCGTATAGCCTGGTGCTGGCGGGGTTGGGCTGCGGCCTGCCGCTGCTGCTCACGC
TGGCAGCCTACGGCGCCCTCGGGCGGGCCGTGCTACGCAGCCCAGGCATGACTGTGGCCGAGAAGCTGCGTGTGGCAGCGTTGGTGGCCA
GTGGTGTGGCCCTCTACGCCAGCTCCTATGTGCCCTACCACATCATGCGGGTGCTCAACGTGGATGCTCGGCGGCGCTGGAGCACCCGCT
GCCCGAGCTTTGCAGACATAGCCCAGGCCACAGCAGCCCTGGAGCTGGGGCCCTACGTGGGCTACCAGGTGATGCGGGGCCTCATGCCCC
TGGCCTTCTGTGTCCACCCTCTACTCTACATGGCCGCAGTGCCCAGCCTGGGCTGCTGCTGCCGACACTGCCCCGGCTACAGGGACAGCT
GGAACCCAGAGGACGCCAAGAGCACTGGCCAAGCCCTGCCCCTCAATGCCACAGCCGCCCCTAAACCGTCAGAGCCCCAGTCCCGTGAGC
TGAGCCAATGATGTGGCCTAGCGGAAGCTGCCTCCTCACCCTAGGTGTTGCTGGAGAACCCTGAGGGCAGGGCCCGAGCCCCGACACATC
CCTTCCCCCAAAAAGCAACACCTGTGCTTGCAGCCAGGTCAGGCCCAGCTGCAGCCCAGGCAGGAGCAGTCGCCTTTCCCACCCACAGCG
CTGGCCACAGGGCTCCCTGCAGGGTCAGGGACCAGACCACGCCCAGAGGAGGGGAGGCACTGGCCCCCGCCACAGGACTGGAGACGCAAG
AACAAAAAGAACCAAGTAGAGAGAGTGGAGCTGCTTTATTGCCCTTGGAGCCCGCGCTCTCGGAGGCTGTCTTCTGTCGCCAAGGGTCCC
GGACCGAGTACACAGTGGCAGCTGGCTTAGTTGGTGGACGGCCTGGGGTAGGGGAGGGTGGCAGGTATAAGACTTCTGGGGGCACCCCAA
GACCCCAGACACCCAAGTGGCATCTTGGGGGTGGGTGGGCAGAGGACGGGGTAATGTGAGGACGAAGCGGGCACGGAGCCAGATGGCCAG
TCTCCAGGCCTGGTCCACGGACTGGCAGGGACCCCAGGCACAAGAGCTGCCACCCCTCTGCCCGGTTTTGGAAAAAAACAATAAAGGACT
GTCCCCTCAAAACCA

>23648_23648_4_DNM2-P2RY11_DNM2_chr19_10913034_ENST00000389253_P2RY11_chr19_10224309_ENST00000321826_length(amino acids)=528AA_BP=498
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQIVKLKEPSLKCVDLVVSELATVIKKCAEKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFAKCQVLPCQLLGSCRRQTQWVPGGLPVAHTGG

--------------------------------------------------------------
>23648_23648_5_DNM2-P2RY11_DNM2_chr19_10913034_ENST00000408974_P2RY11_chr19_10224309_ENST00000321826_length(transcript)=3268nt_BP=1528nt
AGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGATGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACG
CCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTGTAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGG
AGAACTTCGTGGGCCGGGACTTCCTTCCCCGCGGTTCAGGAATCGTCACCCGGCGGCCTCTCATTCTGCAGCTCATCTTCTCAAAAACAG
AACATGCCGAGTTTTTGCACTGCAAGTCCAAAAAGTTTACAGACTTTGATGAAGTCCGGCAGGAGATTGAAGCAGAGACCGACAGGGTCA
CGGGGACCAACAAAGGCATCTCCCCAGTGCCCATCAACCTTCGAGTCTACTCGCCACACGTGTTGAACTTGACCCTCATCGACCTCCCGG
GTATCACCAAGGTGCCTGTGGGCGACCAGCCTCCAGACATCGAGTACCAGATCAAGGACATGATCCTGCAGTTCATCAGCCGGGAGAGCA
GCCTCATTCTGGCTGTCACGCCCGCCAACATGGACCTGGCCAACTCCGACGCCCTCAAGCTGGCCAAGGAAGTCGATCCCCAAGGCCTAC
GGACCATCGGTGTCATCACCAAGCTTGACCTGATGGACGAGGGCACCGACGCCAGGGACGTCTTGGAGAACAAGTTGCTCCCGTTGAGAA
GAGGCTACATTGGCGTGGTGAACCGCAGCCAGAAGGATATTGAGGGCAAGAAGGACATCCGTGCAGCACTGGCAGCTGAGAGGAAGTTCT
TCCTCTCCCACCCGGCCTACCGGCACATGGCCGACCGCATGGGCACGCCACATCTGCAGAAGACGCTGAATCAGCAACTGACCAACCACA
TCCGGGAGTCGCTGCCGGCCCTACGTAGCAAACTACAGAGCCAGCTGCTGTCCCTGGAGAAGGAGGTGGAGGAGTACAAGAACTTTCGGC
CCGACGACCCCACCCGCAAAACCAAAGCCCTGCTGCAGATGGTCCAGCAGTTTGGGGTGGATTTTGAGAAGAGGATCGAGGGCTCAGGAG
ATCAGGTGGACACTCTGGAGCTCTCCGGGGGCGCCCGAATCAATCGCATCTTCCACGAGCGGTTCCCATTTGAGCTGGTGAAGATGGAGT
TTGACGAGAAGGACTTACGACGGGAGATCAGCTATGCCATTAAGAACATCCATGGAGTCAGGACGGGGCTCTTCACCCCCGACATGGCCT
TTGAAGCCATTGTGAAAAAACAGATTGTAAAACTCAAAGAGCCGAGTTTGAAGTGTGTTGATCTCGTGGTCTCAGAGCTGGCCACGGTCA
TAAAAAAGTGTGCCGAGAAGCTCAGTTCCTACCCCCGGTTGCGAGAGGAGACAGAGCGAATCGTCACCACTTACATCCGGGAACGGGAGG
GGAGAACGAAGGACCAGATTCTTCTGCTGATCGACATTGAGCAGTCCTACATCAACACGAACCATGAGGACTTCATCGGGTTTGCCAAGT
GCCAAGTCCTGCCCTGCCAACTTCTTGGCAGCTGCCGACGACAAACTCAGTGGGTTCCAGGGGGACTTCCTGTGGCCCATACTGGTGGTT
GAGTTCCTGGTGGCCGTGGCCAGCAATGGCCTGGCCCTGTACCGCTTCAGCATCCGGAAGCAGCGCCCATGGCACCCCGCCGTGGTCTTC
TCTGTCCAGCTGGCAGTCAGCGACCTGCTCTGCGCCCTGACGCTGCCCCCGCTGGCCGCCTACCTCTATCCCCCCAAGCACTGGCGCTAT
GGGGAGGCCGCGTGCCGCCTGGAGCGCTTCCTCTTCACCTGCAACCTGCTGGGCAGCGTCATCTTCATCACCTGCATCAGCCTCAACCGC
TACCTGGGCATCGTGCACCCCTTCTTCGCCCGAAGCCACCTGCGACCCAAGCACGCCTGGGCCGTGAGCGCTGCCGGCTGGGTCCTGGCC
GCCCTGCTGGCCATGCCCACACTCAGCTTCTCCCACCTGAAGAGGCCGCAGCAGGGGGCGGGCAACTGCAGCGTGGCCAGGCCCGAGGCC
TGCATCAAGTGTCTGGGGACAGCAGACCACGGGCTGGCGGCCTACAGAGCGTATAGCCTGGTGCTGGCGGGGTTGGGCTGCGGCCTGCCG
CTGCTGCTCACGCTGGCAGCCTACGGCGCCCTCGGGCGGGCCGTGCTACGCAGCCCAGGCATGACTGTGGCCGAGAAGCTGCGTGTGGCA
GCGTTGGTGGCCAGTGGTGTGGCCCTCTACGCCAGCTCCTATGTGCCCTACCACATCATGCGGGTGCTCAACGTGGATGCTCGGCGGCGC
TGGAGCACCCGCTGCCCGAGCTTTGCAGACATAGCCCAGGCCACAGCAGCCCTGGAGCTGGGGCCCTACGTGGGCTACCAGGTGATGCGG
GGCCTCATGCCCCTGGCCTTCTGTGTCCACCCTCTACTCTACATGGCCGCAGTGCCCAGCCTGGGCTGCTGCTGCCGACACTGCCCCGGC
TACAGGGACAGCTGGAACCCAGAGGACGCCAAGAGCACTGGCCAAGCCCTGCCCCTCAATGCCACAGCCGCCCCTAAACCGTCAGAGCCC
CAGTCCCGTGAGCTGAGCCAATGATGTGGCCTAGCGGAAGCTGCCTCCTCACCCTAGGTGTTGCTGGAGAACCCTGAGGGCAGGGCCCGA
GCCCCGACACATCCCTTCCCCCAAAAAGCAACACCTGTGCTTGCAGCCAGGTCAGGCCCAGCTGCAGCCCAGGCAGGAGCAGTCGCCTTT
CCCACCCACAGCGCTGGCCACAGGGCTCCCTGCAGGGTCAGGGACCAGACCACGCCCAGAGGAGGGGAGGCACTGGCCCCCGCCACAGGA
CTGGAGACGCAAGAACAAAAAGAACCAAGTAGAGAGAGTGGAGCTGCTTTATTGCCCTTGGAGCCCGCGCTCTCGGAGGCTGTCTTCTGT
CGCCAAGGGTCCCGGACCGAGTACACAGTGGCAGCTGGCTTAGTTGGTGGACGGCCTGGGGTAGGGGAGGGTGGCAGGTATAAGACTTCT
GGGGGCACCCCAAGACCCCAGACACCCAAGTGGCATCTTGGGGGTGGGTGGGCAGAGGACGGGGTAATGTGAGGACGAAGCGGGCACGGA
GCCAGATGGCCAGTCTCCAGGCCTGGTCCACGGACTGGCAGGGACCCCAGGCACAAGAGCTGCCACCCCTCTGCCCGGTTTTGGAAAAAA
ACAATAAAGGACTGTCCCCTCAAAACCA

>23648_23648_5_DNM2-P2RY11_DNM2_chr19_10913034_ENST00000408974_P2RY11_chr19_10224309_ENST00000321826_length(amino acids)=528AA_BP=498
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQIVKLKEPSLKCVDLVVSELATVIKKCAEKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFAKCQVLPCQLLGSCRRQTQWVPGGLPVAHTGG

--------------------------------------------------------------
>23648_23648_6_DNM2-P2RY11_DNM2_chr19_10913034_ENST00000585892_P2RY11_chr19_10224309_ENST00000321826_length(transcript)=3397nt_BP=1657nt
GAGAACCGGATGAGGCGGCGACCGTGAGGCCGAGCCGGGAGCGGGCGTCTTGCCGAGGCCCGGGCGGGCGGGGAGCAACGGCTACAGACG
CCGCGGGGCCAGGTCGTTGAGGGTCGGCGGCGGGCGAGGAGCGCAGGGCGCTCGGGCCGGGGGCCGCCGGCGCCATGGGCAACCGCGGGA
TGGAAGAGCTGATCCCGCTGGTCAACAAACTGCAGGACGCCTTCAGCTCCATCGGCCAGAGCTGCCACCTGGACCTGCCGCAGATCGCTG
TAGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTGGAGAACTTCGTGGGCCGGGACTTCCTTCCCCGCGGTTCAGGAATCGTCACCC
GGCGGCCTCTCATTCTGCAGCTCATCTTCTCAAAAACAGAACATGCCGAGTTTTTGCACTGCAAGTCCAAAAAGTTTACAGACTTTGATG
AAGTCCGGCAGGAGATTGAAGCAGAGACCGACAGGGTCACGGGGACCAACAAAGGCATCTCCCCAGTGCCCATCAACCTTCGAGTCTACT
CGCCACACGTGTTGAACTTGACCCTCATCGACCTCCCGGGTATCACCAAGGTGCCTGTGGGCGACCAGCCTCCAGACATCGAGTACCAGA
TCAAGGACATGATCCTGCAGTTCATCAGCCGGGAGAGCAGCCTCATTCTGGCTGTCACGCCCGCCAACATGGACCTGGCCAACTCCGACG
CCCTCAAGCTGGCCAAGGAAGTCGATCCCCAAGGCCTACGGACCATCGGTGTCATCACCAAGCTTGACCTGATGGACGAGGGCACCGACG
CCAGGGACGTCTTGGAGAACAAGTTGCTCCCGTTGAGAAGAGGCTACATTGGCGTGGTGAACCGCAGCCAGAAGGATATTGAGGGCAAGA
AGGACATCCGTGCAGCACTGGCAGCTGAGAGGAAGTTCTTCCTCTCCCACCCGGCCTACCGGCACATGGCCGACCGCATGGGCACGCCAC
ATCTGCAGAAGACGCTGAATCAGCAACTGACCAACCACATCCGGGAGTCGCTGCCGGCCCTACGTAGCAAACTACAGAGCCAGCTGCTGT
CCCTGGAGAAGGAGGTGGAGGAGTACAAGAACTTTCGGCCCGACGACCCCACCCGCAAAACCAAAGCCCTGCTGCAGATGGTCCAGCAGT
TTGGGGTGGATTTTGAGAAGAGGATCGAGGGCTCAGGAGATCAGGTGGACACTCTGGAGCTCTCCGGGGGCGCCCGAATCAATCGCATCT
TCCACGAGCGGTTCCCATTTGAGCTGGTGAAGATGGAGTTTGACGAGAAGGACTTACGACGGGAGATCAGCTATGCCATTAAGAACATCC
ATGGAGTCAGGACCGGGCTTTTCACCCCGGACTTGGCATTCGAGGCCATTGTGAAAAAGCAGGTCGTCAAGCTGAAAGAGCCCTGTCTGA
AATGTGTCGACCTGGTTATCCAGGAGCTAATCAATACAGTTAGGCAGTGTACCAGTAAGCTCAGTTCCTACCCCCGGTTGCGAGAGGAGA
CAGAGCGAATCGTCACCACTTACATCCGGGAACGGGAGGGGAGAACGAAGGACCAGATTCTTCTGCTGATCGACATTGAGCAGTCCTACA
TCAACACGAACCATGAGGACTTCATCGGGTTTGCCAAGTGCCAAGTCCTGCCCTGCCAACTTCTTGGCAGCTGCCGACGACAAACTCAGT
GGGTTCCAGGGGGACTTCCTGTGGCCCATACTGGTGGTTGAGTTCCTGGTGGCCGTGGCCAGCAATGGCCTGGCCCTGTACCGCTTCAGC
ATCCGGAAGCAGCGCCCATGGCACCCCGCCGTGGTCTTCTCTGTCCAGCTGGCAGTCAGCGACCTGCTCTGCGCCCTGACGCTGCCCCCG
CTGGCCGCCTACCTCTATCCCCCCAAGCACTGGCGCTATGGGGAGGCCGCGTGCCGCCTGGAGCGCTTCCTCTTCACCTGCAACCTGCTG
GGCAGCGTCATCTTCATCACCTGCATCAGCCTCAACCGCTACCTGGGCATCGTGCACCCCTTCTTCGCCCGAAGCCACCTGCGACCCAAG
CACGCCTGGGCCGTGAGCGCTGCCGGCTGGGTCCTGGCCGCCCTGCTGGCCATGCCCACACTCAGCTTCTCCCACCTGAAGAGGCCGCAG
CAGGGGGCGGGCAACTGCAGCGTGGCCAGGCCCGAGGCCTGCATCAAGTGTCTGGGGACAGCAGACCACGGGCTGGCGGCCTACAGAGCG
TATAGCCTGGTGCTGGCGGGGTTGGGCTGCGGCCTGCCGCTGCTGCTCACGCTGGCAGCCTACGGCGCCCTCGGGCGGGCCGTGCTACGC
AGCCCAGGCATGACTGTGGCCGAGAAGCTGCGTGTGGCAGCGTTGGTGGCCAGTGGTGTGGCCCTCTACGCCAGCTCCTATGTGCCCTAC
CACATCATGCGGGTGCTCAACGTGGATGCTCGGCGGCGCTGGAGCACCCGCTGCCCGAGCTTTGCAGACATAGCCCAGGCCACAGCAGCC
CTGGAGCTGGGGCCCTACGTGGGCTACCAGGTGATGCGGGGCCTCATGCCCCTGGCCTTCTGTGTCCACCCTCTACTCTACATGGCCGCA
GTGCCCAGCCTGGGCTGCTGCTGCCGACACTGCCCCGGCTACAGGGACAGCTGGAACCCAGAGGACGCCAAGAGCACTGGCCAAGCCCTG
CCCCTCAATGCCACAGCCGCCCCTAAACCGTCAGAGCCCCAGTCCCGTGAGCTGAGCCAATGATGTGGCCTAGCGGAAGCTGCCTCCTCA
CCCTAGGTGTTGCTGGAGAACCCTGAGGGCAGGGCCCGAGCCCCGACACATCCCTTCCCCCAAAAAGCAACACCTGTGCTTGCAGCCAGG
TCAGGCCCAGCTGCAGCCCAGGCAGGAGCAGTCGCCTTTCCCACCCACAGCGCTGGCCACAGGGCTCCCTGCAGGGTCAGGGACCAGACC
ACGCCCAGAGGAGGGGAGGCACTGGCCCCCGCCACAGGACTGGAGACGCAAGAACAAAAAGAACCAAGTAGAGAGAGTGGAGCTGCTTTA
TTGCCCTTGGAGCCCGCGCTCTCGGAGGCTGTCTTCTGTCGCCAAGGGTCCCGGACCGAGTACACAGTGGCAGCTGGCTTAGTTGGTGGA
CGGCCTGGGGTAGGGGAGGGTGGCAGGTATAAGACTTCTGGGGGCACCCCAAGACCCCAGACACCCAAGTGGCATCTTGGGGGTGGGTGG
GCAGAGGACGGGGTAATGTGAGGACGAAGCGGGCACGGAGCCAGATGGCCAGTCTCCAGGCCTGGTCCACGGACTGGCAGGGACCCCAGG
CACAAGAGCTGCCACCCCTCTGCCCGGTTTTGGAAAAAAACAATAAAGGACTGTCCCCTCAAAACCA

>23648_23648_6_DNM2-P2RY11_DNM2_chr19_10913034_ENST00000585892_P2RY11_chr19_10224309_ENST00000321826_length(amino acids)=528AA_BP=498
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFAKCQVLPCQLLGSCRRQTQWVPGGLPVAHTGG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DNM2-P2RY11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNM2-P2RY11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DNM2-P2RY11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNM2C4551952Myopathy, Centronuclear, 113CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneDNM2C1847902CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE B (disorder)8CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneDNM2C1834558Myopathy, Centronuclear, Autosomal Dominant7CLINGEN;CTD_human;ORPHANET
HgeneDNM2C0175709Centronuclear myopathy2CTD_human;GENOMICS_ENGLAND
HgeneDNM2C3809272LETHAL CONGENITAL CONTRACTURE SYNDROME 52CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneDNM2C0410203X-linked centronuclear myopathy1CTD_human
HgeneDNM2C0410207Tubular Aggregate Myopathy1CTD_human
HgeneDNM2C0546264Congenital Fiber Type Disproportion1CTD_human
HgeneDNM2C0752282Congenital Structural Myopathy1CTD_human
HgeneDNM2C3645536Autosomal Recessive Centronuclear Myopathy1CTD_human
HgeneDNM2C3661489Autosomal Dominant Myotubular Myopathy1CTD_human
TgeneC0027404Narcolepsy2CTD_human;ORPHANET
TgeneC0751362Narcolepsy-Cataplexy Syndrome2CTD_human;ORPHANET