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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNM2-TAGLN2 (FusionGDB2 ID:HG1785TG8407)

Fusion Gene Summary for DNM2-TAGLN2

check button Fusion gene summary
Fusion gene informationFusion gene name: DNM2-TAGLN2
Fusion gene ID: hg1785tg8407
HgeneTgene
Gene symbol

DNM2

TAGLN2

Gene ID

1785

8407

Gene namedynamin 2transgelin 2
SynonymsCMT2M|CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII|LCCS5HA1756
Cytomap('DNM2')('TAGLN2')

19p13.2

1q23.2

Type of geneprotein-codingprotein-coding
Descriptiondynamin-2dynamin IItransgelin-2SM22-alpha homologepididymis secretory sperm binding proteinepididymis tissue protein Li 7e
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000591819, ENST00000314646, 
ENST00000355667, ENST00000359692, 
ENST00000389253, ENST00000408974, 
ENST00000585892, 
Fusion gene scores* DoF score36 X 17 X 17=104047 X 8 X 3=168
# samples 499
** MAII scorelog2(49/10404*10)=-4.40821274494042
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNM2 [Title/Abstract] AND TAGLN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNM2(10886491)-TAGLN2(159890160), # samples:1
Anticipated loss of major functional domain due to fusion event.DNM2-TAGLN2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
DNM2-TAGLN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DNM2-TAGLN2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNM2

GO:1903526

negative regulation of membrane tubulation

18388313

TgeneTAGLN2

GO:0030855

epithelial cell differentiation

21492153



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-A03F-01ADNM2chr19

10886491

+TAGLN2chr1

159890160

-


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Fusion Gene ORF analysis for DNM2-TAGLN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000591819ENST00000368096DNM2chr19

10886491

+TAGLN2chr1

159890160

-
3UTR-3CDSENST00000591819ENST00000368097DNM2chr19

10886491

+TAGLN2chr1

159890160

-
3UTR-5UTRENST00000591819ENST00000320307DNM2chr19

10886491

+TAGLN2chr1

159890160

-
3UTR-5UTRENST00000591819ENST00000478033DNM2chr19

10886491

+TAGLN2chr1

159890160

-
5CDS-5UTRENST00000314646ENST00000320307DNM2chr19

10886491

+TAGLN2chr1

159890160

-
5CDS-5UTRENST00000314646ENST00000478033DNM2chr19

10886491

+TAGLN2chr1

159890160

-
5CDS-5UTRENST00000355667ENST00000320307DNM2chr19

10886491

+TAGLN2chr1

159890160

-
5CDS-5UTRENST00000355667ENST00000478033DNM2chr19

10886491

+TAGLN2chr1

159890160

-
5CDS-5UTRENST00000359692ENST00000320307DNM2chr19

10886491

+TAGLN2chr1

159890160

-
5CDS-5UTRENST00000359692ENST00000478033DNM2chr19

10886491

+TAGLN2chr1

159890160

-
5CDS-5UTRENST00000389253ENST00000320307DNM2chr19

10886491

+TAGLN2chr1

159890160

-
5CDS-5UTRENST00000389253ENST00000478033DNM2chr19

10886491

+TAGLN2chr1

159890160

-
5CDS-5UTRENST00000408974ENST00000320307DNM2chr19

10886491

+TAGLN2chr1

159890160

-
5CDS-5UTRENST00000408974ENST00000478033DNM2chr19

10886491

+TAGLN2chr1

159890160

-
5CDS-5UTRENST00000585892ENST00000320307DNM2chr19

10886491

+TAGLN2chr1

159890160

-
5CDS-5UTRENST00000585892ENST00000478033DNM2chr19

10886491

+TAGLN2chr1

159890160

-
Frame-shiftENST00000314646ENST00000368096DNM2chr19

10886491

+TAGLN2chr1

159890160

-
Frame-shiftENST00000314646ENST00000368097DNM2chr19

10886491

+TAGLN2chr1

159890160

-
Frame-shiftENST00000355667ENST00000368096DNM2chr19

10886491

+TAGLN2chr1

159890160

-
Frame-shiftENST00000355667ENST00000368097DNM2chr19

10886491

+TAGLN2chr1

159890160

-
Frame-shiftENST00000359692ENST00000368096DNM2chr19

10886491

+TAGLN2chr1

159890160

-
Frame-shiftENST00000359692ENST00000368097DNM2chr19

10886491

+TAGLN2chr1

159890160

-
Frame-shiftENST00000389253ENST00000368096DNM2chr19

10886491

+TAGLN2chr1

159890160

-
Frame-shiftENST00000389253ENST00000368097DNM2chr19

10886491

+TAGLN2chr1

159890160

-
Frame-shiftENST00000408974ENST00000368096DNM2chr19

10886491

+TAGLN2chr1

159890160

-
Frame-shiftENST00000408974ENST00000368097DNM2chr19

10886491

+TAGLN2chr1

159890160

-
Frame-shiftENST00000585892ENST00000368096DNM2chr19

10886491

+TAGLN2chr1

159890160

-
Frame-shiftENST00000585892ENST00000368097DNM2chr19

10886491

+TAGLN2chr1

159890160

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DNM2-TAGLN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for DNM2-TAGLN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:10886491/:159890160)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DNM2-TAGLN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DNM2-TAGLN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNM2-TAGLN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DNM2-TAGLN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNM2C4551952Myopathy, Centronuclear, 113CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneDNM2C1847902CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE B (disorder)8CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneDNM2C1834558Myopathy, Centronuclear, Autosomal Dominant7CLINGEN;CTD_human;ORPHANET
HgeneDNM2C0175709Centronuclear myopathy2CTD_human;GENOMICS_ENGLAND
HgeneDNM2C3809272LETHAL CONGENITAL CONTRACTURE SYNDROME 52CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneDNM2C0410203X-linked centronuclear myopathy1CTD_human
HgeneDNM2C0410207Tubular Aggregate Myopathy1CTD_human
HgeneDNM2C0546264Congenital Fiber Type Disproportion1CTD_human
HgeneDNM2C0752282Congenital Structural Myopathy1CTD_human
HgeneDNM2C3645536Autosomal Recessive Centronuclear Myopathy1CTD_human
HgeneDNM2C3661489Autosomal Dominant Myotubular Myopathy1CTD_human
TgeneC0007134Renal Cell Carcinoma1CTD_human
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0023890Liver Cirrhosis1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0239946Fibrosis, Liver1CTD_human
TgeneC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneC1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneC2239176Liver carcinoma1CTD_human
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human