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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DOCK1-MGMT (FusionGDB2 ID:HG1793TG4255) |
Fusion Gene Summary for DOCK1-MGMT |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DOCK1-MGMT | Fusion gene ID: hg1793tg4255 | Hgene | Tgene | Gene symbol | DOCK1 | MGMT | Gene ID | 1793 | 4255 |
| Gene name | dedicator of cytokinesis 1 | O-6-methylguanine-DNA methyltransferase | |
| Synonyms | DOCK180|ced5 | - | |
| Cytomap | ('DOCK1')('MGMT') 10q26.2 | 10q26.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dedicator of cytokinesis protein 1180 kDa protein downstream of CRKDOwnstream of CrK | methylated-DNA--protein-cysteine methyltransferase6-O-methylguanine-DNA methyltransferaseO-6-methylguanine-DNA-alkyltransferaseO6-methylguanine-DNA methyltransferasemethylguanine-DNA methyltransferase | |
| Modification date | 20200327 | 20200315 | |
| UniProtAcc | Q14185 | P16455 | |
| Ensembl transtripts involved in fusion gene | ENST00000280333, ENST00000484400, | ENST00000484400, ENST00000280333, | |
| Fusion gene scores | * DoF score | 17 X 17 X 11=3179 | 19 X 11 X 7=1463 |
| # samples | 20 | 18 | |
| ** MAII score | log2(20/3179*10)=-3.99050111136325 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/1463*10)=-3.02286095780881 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DOCK1 [Title/Abstract] AND MGMT [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DOCK1(128769049)-MGMT(131506159), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | MGMT-DOCK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MGMT-DOCK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DOCK1-MGMT seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. DOCK1-MGMT seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MGMT | GO:0043066 | negative regulation of apoptotic process | 24147153 |
| Tgene | MGMT | GO:2000781 | positive regulation of double-strand break repair | 24147153 |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-AN-A0AS-01A | DOCK1 | chr10 | 128769049 | - | MGMT | chr10 | 131506159 | + |
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Fusion Gene ORF analysis for DOCK1-MGMT |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000280333 | ENST00000462672 | DOCK1 | chr10 | 128769049 | - | MGMT | chr10 | 131506159 | + |
| Frame-shift | ENST00000280333 | ENST00000306010 | DOCK1 | chr10 | 128769049 | - | MGMT | chr10 | 131506159 | + |
| intron-3CDS | ENST00000484400 | ENST00000306010 | DOCK1 | chr10 | 128769049 | - | MGMT | chr10 | 131506159 | + |
| intron-3UTR | ENST00000484400 | ENST00000462672 | DOCK1 | chr10 | 128769049 | - | MGMT | chr10 | 131506159 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for DOCK1-MGMT |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for DOCK1-MGMT |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:128769049/:131506159) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DOCK1 | MGMT |
| FUNCTION: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152). {ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:8657152}. | FUNCTION: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for DOCK1-MGMT |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for DOCK1-MGMT |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DOCK1-MGMT |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | MGMT | P16455 | DB14548 | Zinc sulfate, unspecified form | Stabilization | Small molecule | Approved|Experimental |
| Tgene | MGMT | P16455 | DB01593 | Zinc | Small molecule | Approved|Investigational | |
| Tgene | MGMT | P16455 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
| Tgene | MGMT | P16455 | DB14533 | Zinc chloride | Stabilization | Small molecule | Approved|Investigational |
| Tgene | MGMT | P16455 | DB00151 | Cysteine | Small molecule | Approved|Nutraceutical |
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Related Diseases for DOCK1-MGMT |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DOCK1 | C0013146 | Drug abuse | 1 | CTD_human |
| Hgene | DOCK1 | C0013170 | Drug habituation | 1 | CTD_human |
| Hgene | DOCK1 | C0013222 | Drug Use Disorders | 1 | CTD_human |
| Hgene | DOCK1 | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human |
| Hgene | DOCK1 | C0038580 | Substance Dependence | 1 | CTD_human |
| Hgene | DOCK1 | C0038586 | Substance Use Disorders | 1 | CTD_human |
| Hgene | DOCK1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Hgene | DOCK1 | C0740858 | Substance abuse problem | 1 | CTD_human |
| Hgene | DOCK1 | C1510472 | Drug Dependence | 1 | CTD_human |
| Hgene | DOCK1 | C4316881 | Prescription Drug Abuse | 1 | CTD_human |
| Tgene | C0334588 | Giant Cell Glioblastoma | 4 | CTD_human;ORPHANET | |
| Tgene | C0017638 | Glioma | 3 | CTD_human | |
| Tgene | C0259783 | mixed gliomas | 3 | CTD_human | |
| Tgene | C0555198 | Malignant Glioma | 3 | CTD_human | |
| Tgene | C0017636 | Glioblastoma | 2 | CTD_human | |
| Tgene | C0206726 | gliosarcoma | 2 | ORPHANET | |
| Tgene | C1621958 | Glioblastoma Multiforme | 2 | CTD_human | |
| Tgene | C0006118 | Brain Neoplasms | 1 | CTD_human | |
| Tgene | C0023418 | leukemia | 1 | CTD_human | |
| Tgene | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human | |
| Tgene | C0026640 | Mouth Neoplasms | 1 | CTD_human | |
| Tgene | C0027540 | Necrosis | 1 | CTD_human | |
| Tgene | C0032927 | Precancerous Conditions | 1 | CTD_human | |
| Tgene | C0153381 | Malignant neoplasm of mouth | 1 | CTD_human | |
| Tgene | C0153633 | Malignant neoplasm of brain | 1 | CTD_human | |
| Tgene | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human | |
| Tgene | C0282313 | Condition, Preneoplastic | 1 | CTD_human | |
| Tgene | C0496899 | Benign neoplasm of brain, unspecified | 1 | CTD_human | |
| Tgene | C0750974 | Brain Tumor, Primary | 1 | CTD_human | |
| Tgene | C0750977 | Recurrent Brain Neoplasm | 1 | CTD_human | |
| Tgene | C0750979 | Primary malignant neoplasm of brain | 1 | CTD_human | |
| Tgene | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human | |
| Tgene | C1449861 | Micronuclei, Chromosome-Defective | 1 | CTD_human | |
| Tgene | C1449862 | Micronuclei, Genotoxicant-Induced | 1 | CTD_human | |
| Tgene | C1527390 | Neoplasms, Intracranial | 1 | CTD_human | |
| Tgene | C2314896 | Familial Atypical Mole Melanoma Syndrome | 1 | ORPHANET |
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