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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARID3A-MORC2 (FusionGDB2 ID:HG1820TG22880)

Fusion Gene Summary for ARID3A-MORC2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARID3A-MORC2
Fusion gene ID: hg1820tg22880
HgeneTgene
Gene symbol

ARID3A

MORC2

Gene ID

1820

22880

Gene nameAT-rich interaction domain 3AMORC family CW-type zinc finger 2
SynonymsBRIGHT|DRIL1|DRIL3|E2FBP1CMT2Z|ZCW3|ZCWCC1
Cytomap('ARID3A')('MORC2')

19p13.3

22q12.2

Type of geneprotein-codingprotein-coding
DescriptionAT-rich interactive domain-containing protein 3AARID domain-containing 3AARID domain-containing protein 3AAT rich interactive domain 3A (BRIGHT- like) proteinAT rich interactive domain 3A (BRIGHT-like)B-cell regulator of IgH transcriptionE2F-bindingATPase MORC2zinc finger CW-type coiled-coil domain protein 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263620, ENST00000592216, 
Fusion gene scores* DoF score7 X 6 X 6=2525 X 5 X 5=125
# samples 85
** MAII scorelog2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARID3A [Title/Abstract] AND MORC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARID3A(929896)-MORC2(31328756), # samples:4
Anticipated loss of major functional domain due to fusion event.ARID3A-MORC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID3A-MORC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID3A-MORC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID3A-MORC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMORC2

GO:0006338

chromatin remodeling

23260667

TgeneMORC2

GO:0006974

cellular response to DNA damage stimulus

23260667

TgeneMORC2

GO:0045814

negative regulation of gene expression, epigenetic

28581500|29211708

TgeneMORC2

GO:0090309

positive regulation of methylation-dependent chromatin silencing

28581500|29211708


check buttonFusion gene breakpoints across ARID3A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MORC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-EY-A2ON-01AARID3Achr19

929895

+MORC2chr22

31328755

-
ChimerDB4UCECTCGA-EY-A2ON-01AARID3Achr19

929896

-MORC2chr22

31328756

-
ChimerDB4UCECTCGA-EY-A2ON-01AARID3Achr19

929896

+MORC2chr22

31328756

-
ChimerDB4UCECTCGA-EY-A2ONARID3Achr19

929896

+MORC2chr22

31328756

-


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Fusion Gene ORF analysis for ARID3A-MORC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263620ENST00000469915ARID3Achr19

929895

+MORC2chr22

31328755

-
5CDS-intronENST00000263620ENST00000469915ARID3Achr19

929896

+MORC2chr22

31328756

-
In-frameENST00000263620ENST00000215862ARID3Achr19

929895

+MORC2chr22

31328755

-
In-frameENST00000263620ENST00000215862ARID3Achr19

929896

+MORC2chr22

31328756

-
In-frameENST00000263620ENST00000397641ARID3Achr19

929895

+MORC2chr22

31328755

-
In-frameENST00000263620ENST00000397641ARID3Achr19

929896

+MORC2chr22

31328756

-
intron-3CDSENST00000592216ENST00000215862ARID3Achr19

929895

+MORC2chr22

31328755

-
intron-3CDSENST00000592216ENST00000215862ARID3Achr19

929896

+MORC2chr22

31328756

-
intron-3CDSENST00000592216ENST00000397641ARID3Achr19

929895

+MORC2chr22

31328755

-
intron-3CDSENST00000592216ENST00000397641ARID3Achr19

929896

+MORC2chr22

31328756

-
intron-intronENST00000592216ENST00000469915ARID3Achr19

929895

+MORC2chr22

31328755

-
intron-intronENST00000592216ENST00000469915ARID3Achr19

929896

+MORC2chr22

31328756

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263620ARID3Achr19929896+ENST00000397641MORC2chr2231328756-29456951861271361
ENST00000263620ARID3Achr19929896+ENST00000215862MORC2chr2231328756-14646951861271361
ENST00000263620ARID3Achr19929895+ENST00000397641MORC2chr2231328755-29456951861271361
ENST00000263620ARID3Achr19929895+ENST00000215862MORC2chr2231328755-14646951861271361

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263620ENST00000397641ARID3Achr19929896+MORC2chr2231328756-0.0014374520.9985625
ENST00000263620ENST00000215862ARID3Achr19929896+MORC2chr2231328756-0.0037537190.9962463
ENST00000263620ENST00000397641ARID3Achr19929895+MORC2chr2231328755-0.0014374520.9985625
ENST00000263620ENST00000215862ARID3Achr19929895+MORC2chr2231328755-0.0037537190.9962463

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Fusion Genomic Features for ARID3A-MORC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ARID3A-MORC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:929896/chr22:31328756)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID3Achr19:929895chr22:31328755ENST00000263620+2967_70122594.0Compositional biasNote=Poly-Ala
HgeneARID3Achr19:929896chr22:31328756ENST00000263620+2967_70122594.0Compositional biasNote=Poly-Ala
TgeneMORC2chr19:929895chr22:31328755ENST000002158622227966_1016778971.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr19:929895chr22:31328755ENST000003976412126966_10168401033.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr19:929896chr22:31328756ENST000002158622227966_1016778971.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr19:929896chr22:31328756ENST000003976412126966_10168401033.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID3Achr19:929895chr22:31328755ENST00000263620+29424_445122594.0Compositional biasNote=Ala-rich
HgeneARID3Achr19:929895chr22:31328755ENST00000263620+29550_579122594.0Compositional biasNote=Gly-rich
HgeneARID3Achr19:929895chr22:31328755ENST00000263620+2989_157122594.0Compositional biasNote=Glu-rich
HgeneARID3Achr19:929896chr22:31328756ENST00000263620+29424_445122594.0Compositional biasNote=Ala-rich
HgeneARID3Achr19:929896chr22:31328756ENST00000263620+29550_579122594.0Compositional biasNote=Gly-rich
HgeneARID3Achr19:929896chr22:31328756ENST00000263620+2989_157122594.0Compositional biasNote=Glu-rich
HgeneARID3Achr19:929895chr22:31328755ENST00000263620+29238_330122594.0DomainARID
HgeneARID3Achr19:929895chr22:31328755ENST00000263620+29444_541122594.0DomainREKLES
HgeneARID3Achr19:929896chr22:31328756ENST00000263620+29238_330122594.0DomainARID
HgeneARID3Achr19:929896chr22:31328756ENST00000263620+29444_541122594.0DomainREKLES
HgeneARID3Achr19:929895chr22:31328755ENST00000263620+29119_156122594.0RegionNote=Acidic
HgeneARID3Achr19:929895chr22:31328755ENST00000263620+29445_488122594.0RegionImportant for nuclear localization
HgeneARID3Achr19:929895chr22:31328755ENST00000263620+29490_513122594.0RegionNote=Homodimerization
HgeneARID3Achr19:929895chr22:31328755ENST00000263620+29537_557122594.0RegionImportant for cytoplasmic localization
HgeneARID3Achr19:929896chr22:31328756ENST00000263620+29119_156122594.0RegionNote=Acidic
HgeneARID3Achr19:929896chr22:31328756ENST00000263620+29445_488122594.0RegionImportant for nuclear localization
HgeneARID3Achr19:929896chr22:31328756ENST00000263620+29490_513122594.0RegionNote=Homodimerization
HgeneARID3Achr19:929896chr22:31328756ENST00000263620+29537_557122594.0RegionImportant for cytoplasmic localization
TgeneMORC2chr19:929895chr22:31328755ENST000002158622227282_362778971.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr19:929895chr22:31328755ENST000002158622227547_584778971.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr19:929895chr22:31328755ENST000002158622227741_761778971.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr19:929895chr22:31328755ENST000003976412126282_3628401033.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr19:929895chr22:31328755ENST000003976412126547_5848401033.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr19:929895chr22:31328755ENST000003976412126741_7618401033.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr19:929896chr22:31328756ENST000002158622227282_362778971.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr19:929896chr22:31328756ENST000002158622227547_584778971.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr19:929896chr22:31328756ENST000002158622227741_761778971.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr19:929896chr22:31328756ENST000003976412126282_3628401033.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr19:929896chr22:31328756ENST000003976412126547_5848401033.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr19:929896chr22:31328756ENST000003976412126741_7618401033.0Coiled coilOntology_term=ECO:0000255
TgeneMORC2chr19:929895chr22:31328755ENST00000215862222787_89778971.0Nucleotide bindingATP
TgeneMORC2chr19:929895chr22:31328755ENST00000215862222799_105778971.0Nucleotide bindingATP
TgeneMORC2chr19:929895chr22:31328755ENST00000397641212687_898401033.0Nucleotide bindingATP
TgeneMORC2chr19:929895chr22:31328755ENST00000397641212699_1058401033.0Nucleotide bindingATP
TgeneMORC2chr19:929896chr22:31328756ENST00000215862222787_89778971.0Nucleotide bindingATP
TgeneMORC2chr19:929896chr22:31328756ENST00000215862222799_105778971.0Nucleotide bindingATP
TgeneMORC2chr19:929896chr22:31328756ENST00000397641212687_898401033.0Nucleotide bindingATP
TgeneMORC2chr19:929896chr22:31328756ENST00000397641212699_1058401033.0Nucleotide bindingATP
TgeneMORC2chr19:929895chr22:31328755ENST000002158622227490_544778971.0Zinc fingerCW-type
TgeneMORC2chr19:929895chr22:31328755ENST000003976412126490_5448401033.0Zinc fingerCW-type
TgeneMORC2chr19:929896chr22:31328756ENST000002158622227490_544778971.0Zinc fingerCW-type
TgeneMORC2chr19:929896chr22:31328756ENST000003976412126490_5448401033.0Zinc fingerCW-type


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Fusion Gene Sequence for ARID3A-MORC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6448_6448_1_ARID3A-MORC2_ARID3A_chr19_929895_ENST00000263620_MORC2_chr22_31328755_ENST00000215862_length(transcript)=1464nt_BP=695nt
GCGGGGCGCCTCTTACCAATCGGGCGGAGGGGTGTAGACGCGGACGCGGCTGGCGGCTCGGTTTCTGCAAATGCGTGAATGAGCCGGATG
CCAGCCTCTGTCCCCTGGAGCCCAGCGTGAGGAAGAGGCATGCCCCATCAGCCTTCAGCTTGAGCCCGGCGGCCCCCGCCCCCGCCCCCT
GCCACCCTGCACTGCCCCGGCTCCCCCGCGGCCCCCACGCTGCAGTGCGGCCGGGCCCCCTCCCCGCAGGGGCCGCCCCCGCCGCCCACC
CCTAGCGCCCGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGCCCGGGCCGCAGGGCCATGAAACTACAGGCCGTGATGGAGACGCTGTTG
CAGCGGCAGCAGCGGGCGCGCCAGGAGCTGGAGGCCCGGCAGCAGCTGCCCCCCGATCCCCCTGCTGCACCCCCCGGCCGGGCCCGGGCT
GCCCCCGACGAGGACAGAGAGCCCGAGAGTGCCCGGATGCAGCGGGCTCAGATGGCCGCACTGGCAGCCATGCGGGCTGCAGCTGCGGGC
CTGGGACACCCAGCCAGCCCCGGCGGCTCTGAGGATGGGCCCCCAGGCTCGGAGGAGGAGGACGCGGCCCGGGAGGGGACACCGGGCTCA
CCCGGGCGAGGCAGAGAAGGGCCAGGAGAGGAGCACTTTGAGGACATGGCCTCCGACGAGGACATGGTGGAGAAAGGCAGTGAGGATGTG
CGGCTGATGAAACCCCCTTCTCCGGAACATCAGAGCCTTGATACACAACAGGAGGGCGGGGAGGAGGAGGTGGGCCCTGTGGCCCAGCAG
GCCATAGCTGTCGCAGAGCCCTCCACTTCCGAATGCCTCCGCATTGAGCCTGACACCACTGCCCTGAGCACCAATCACGAGACCATCGAC
CTGCTTGTCCAGATCCTCCGGAATTGTTTACGGTACTTCCTGCCTCCAAGTTTCCCCATCTCCAAGAAGCAGCTGAGTGCTATGAATTCA
GATGAGCTAATATCTTTTCCTCTGAAGGAGTACTTCAAGCAATATGAAGTAGGGCTCCAAAACCTGTGCAATTCCTACCAGAGCCGTGCT
GACTCCCGGGCCAAGGCCTCCGAGGAAAGCCTGCGCACCTCCGAGAGGAAGCTCCGCGAGACGGAGGAGAAGCTGCAGAAGCTGAGGACC
AACATCGTGGCACTCCTGCAAAAGGTGCAGGAGGACATAGACATCAACACAGATGATGAGCTGGACGCCTACATTGAGGACCTCATCACC
AAGGGGGACTGAAGGCAGGAGAGAGAGCAGCTCCCCTGCCCACCTGCCCCTCAACCCTGTAGCTGCAGGGGGAGGGGACTTCATTCATGG
GTTGGTGGTCGCACCTTGGTTTGACTTACACGGGACATTTGTGTTTTTGGAGGAAAAGATACCCTGATTCTTTGAATCTTCCTTAAGTTT
ATAAATATTTATTTTTTAAAAGAA

>6448_6448_1_ARID3A-MORC2_ARID3A_chr19_929895_ENST00000263620_MORC2_chr22_31328755_ENST00000215862_length(amino acids)=361AA_BP=170
MHCPGSPAAPTLQCGRAPSPQGPPPPPTPSARGGGGGGGGGGPGRRAMKLQAVMETLLQRQQRARQELEARQQLPPDPPAAPPGRARAAP
DEDREPESARMQRAQMAALAAMRAAAAGLGHPASPGGSEDGPPGSEEEDAAREGTPGSPGRGREGPGEEHFEDMASDEDMVEKGSEDVRL
MKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALSTNHETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDE
LISFPLKEYFKQYEVGLQNLCNSYQSRADSRAKASEESLRTSERKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKG
D

--------------------------------------------------------------
>6448_6448_2_ARID3A-MORC2_ARID3A_chr19_929895_ENST00000263620_MORC2_chr22_31328755_ENST00000397641_length(transcript)=2945nt_BP=695nt
GCGGGGCGCCTCTTACCAATCGGGCGGAGGGGTGTAGACGCGGACGCGGCTGGCGGCTCGGTTTCTGCAAATGCGTGAATGAGCCGGATG
CCAGCCTCTGTCCCCTGGAGCCCAGCGTGAGGAAGAGGCATGCCCCATCAGCCTTCAGCTTGAGCCCGGCGGCCCCCGCCCCCGCCCCCT
GCCACCCTGCACTGCCCCGGCTCCCCCGCGGCCCCCACGCTGCAGTGCGGCCGGGCCCCCTCCCCGCAGGGGCCGCCCCCGCCGCCCACC
CCTAGCGCCCGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGCCCGGGCCGCAGGGCCATGAAACTACAGGCCGTGATGGAGACGCTGTTG
CAGCGGCAGCAGCGGGCGCGCCAGGAGCTGGAGGCCCGGCAGCAGCTGCCCCCCGATCCCCCTGCTGCACCCCCCGGCCGGGCCCGGGCT
GCCCCCGACGAGGACAGAGAGCCCGAGAGTGCCCGGATGCAGCGGGCTCAGATGGCCGCACTGGCAGCCATGCGGGCTGCAGCTGCGGGC
CTGGGACACCCAGCCAGCCCCGGCGGCTCTGAGGATGGGCCCCCAGGCTCGGAGGAGGAGGACGCGGCCCGGGAGGGGACACCGGGCTCA
CCCGGGCGAGGCAGAGAAGGGCCAGGAGAGGAGCACTTTGAGGACATGGCCTCCGACGAGGACATGGTGGAGAAAGGCAGTGAGGATGTG
CGGCTGATGAAACCCCCTTCTCCGGAACATCAGAGCCTTGATACACAACAGGAGGGCGGGGAGGAGGAGGTGGGCCCTGTGGCCCAGCAG
GCCATAGCTGTCGCAGAGCCCTCCACTTCCGAATGCCTCCGCATTGAGCCTGACACCACTGCCCTGAGCACCAATCACGAGACCATCGAC
CTGCTTGTCCAGATCCTCCGGAATTGTTTACGGTACTTCCTGCCTCCAAGTTTCCCCATCTCCAAGAAGCAGCTGAGTGCTATGAATTCA
GATGAGCTAATATCTTTTCCTCTGAAGGAGTACTTCAAGCAATATGAAGTAGGGCTCCAAAACCTGTGCAATTCCTACCAGAGCCGTGCT
GACTCCCGGGCCAAGGCCTCCGAGGAAAGCCTGCGCACCTCCGAGAGGAAGCTCCGCGAGACGGAGGAGAAGCTGCAGAAGCTGAGGACC
AACATCGTGGCACTCCTGCAAAAGGTGCAGGAGGACATAGACATCAACACAGATGATGAGCTGGACGCCTACATTGAGGACCTCATCACC
AAGGGGGACTGAAGGCAGGAGAGAGAGCAGCTCCCCTGCCCACCTGCCCCTCAACCCTGTAGCTGCAGGGGGAGGGGACTTCATTCATGG
GTTGGTGGTCGCACCTTGGTTTGACTTACACGGGACATTTGTGTTTTTGGAGGAAAAGATACCCTGATTCTTTGAATCTTCCTTAAGTTT
ATAAATATTTATTTTTTAAAAGAAGATGCTGTGCCTGTGAGACCATACTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGTGAC
TGCAAAGGACAGAGAACCTTTCCACTTTGGCCATACTGGGTTGCTAAGCCGGAGCCATTTCAGCTCCTGGCTCCTCAAGATAACGGCGAG
TCCAGTGCCATCTTGGAGAAGCTCCAGGGGCAGGGCTGACTTTTCTCCTACAGGAGGAACAATGTGGGGATCTGAGGGATGGGAGGGAGA
CTTCCCCCTAGAGTGGTGGTCCTGCTGGGGGCTCATATCCAGGGACCCAAAAGGGGGGCTGTGTAGGAGGTTCCACATTGGAGGGGCTCT
CTCTCTCGCAGCTGTCAGAGTTGGTCCTGGCTGTGGCGTCCAAACAGCTTGAGGGAAAAAGATCCTGTCTAACCACCTCATCTACTACTC
AAGTTCTTTCTGAAGGAGGGATTTCTTCAGTTAACCATGGACAGTGAGGTTTCTCACCACAGTAACTTGAGTCCAGGTTGAGGGGGAGAC
AGATCTGTGGTAAATCTCTGACTTGGGCAGCACACTGAGTGTGGAACCCCACAGGACTCCTTAGGGAAGGAGCTTGTGTGTGAAAGAACC
CCTGGGGCTGAGCTGGTGACCTCCATGTGTGGGTGCAGCAGGGCCTTGGATGGTGCCAATTGATCTGGACAGCCTGTTGATGCTTTTCTA
CTTCCACCCTTCGGCCTGGCCCCACTGAGCCCCATCAAGGTGCCTGAAGAGGGGGCCAGTGAGATCCCGTGGCCACAGGGACTCCAGAGG
CATCTCTGCAGGAAGCACACCATGCCTTCCCTCCATGTTCCATCACGGCGCCACAATCTGTGTCCCTTAACTTCTCAGGGTCAAAGACAA
AGGCAAGCGTTGCTGAATTTTCTCTTTAATGGCCATTGGAAGAGTCTGGTTCAGTTTTTCCCAACTCTCTTCCCACTCGTATTTGGGGCC
TCTGGGTTTTCTGAAGGCACAAGGACTGTGACTTTGTACCACTAACCTGTGGTTCAAACCTGGGTGTGTTTCTGGCATCTCCCTAACCCA
GATCAGCAATGGCCACCCTGCTCCTCTGAGGTCAGCAGAAGACTGGGAAGCAGAGGTGAGGGATGCAGGCCACACTGGAATGGGAAGTCT
TTTCCCCACTGGATGTGCCTGTCTGGTGGGTTTTGGACCTTCCCAGACTACATCTCTAGGAGAGGCCTGTTTGGAGTAGTACACTGAGAG
ACCCTGGCCTCTTCTGCTGGAAGACTGTCCAAGTCTTGGGGTTTCTTGAGCTGGTGATTCCTCTGCCATCCTGCTCTCTCTCTTCATCTC
AGGCAGCATGGGGTCCACTTTTGTCCCCAAACCTAATGTTTTAATCCAAATGCAAATTGGTTCCACATTTTTACTGGAGGGTAATCAGTT
TTTAAAATTCACACACATGTAATCGAAACGCAATACTATAAAGTTCTACTGGTGAGACTCCTGAA

>6448_6448_2_ARID3A-MORC2_ARID3A_chr19_929895_ENST00000263620_MORC2_chr22_31328755_ENST00000397641_length(amino acids)=361AA_BP=170
MHCPGSPAAPTLQCGRAPSPQGPPPPPTPSARGGGGGGGGGGPGRRAMKLQAVMETLLQRQQRARQELEARQQLPPDPPAAPPGRARAAP
DEDREPESARMQRAQMAALAAMRAAAAGLGHPASPGGSEDGPPGSEEEDAAREGTPGSPGRGREGPGEEHFEDMASDEDMVEKGSEDVRL
MKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALSTNHETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDE
LISFPLKEYFKQYEVGLQNLCNSYQSRADSRAKASEESLRTSERKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKG
D

--------------------------------------------------------------
>6448_6448_3_ARID3A-MORC2_ARID3A_chr19_929896_ENST00000263620_MORC2_chr22_31328756_ENST00000215862_length(transcript)=1464nt_BP=695nt
GCGGGGCGCCTCTTACCAATCGGGCGGAGGGGTGTAGACGCGGACGCGGCTGGCGGCTCGGTTTCTGCAAATGCGTGAATGAGCCGGATG
CCAGCCTCTGTCCCCTGGAGCCCAGCGTGAGGAAGAGGCATGCCCCATCAGCCTTCAGCTTGAGCCCGGCGGCCCCCGCCCCCGCCCCCT
GCCACCCTGCACTGCCCCGGCTCCCCCGCGGCCCCCACGCTGCAGTGCGGCCGGGCCCCCTCCCCGCAGGGGCCGCCCCCGCCGCCCACC
CCTAGCGCCCGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGCCCGGGCCGCAGGGCCATGAAACTACAGGCCGTGATGGAGACGCTGTTG
CAGCGGCAGCAGCGGGCGCGCCAGGAGCTGGAGGCCCGGCAGCAGCTGCCCCCCGATCCCCCTGCTGCACCCCCCGGCCGGGCCCGGGCT
GCCCCCGACGAGGACAGAGAGCCCGAGAGTGCCCGGATGCAGCGGGCTCAGATGGCCGCACTGGCAGCCATGCGGGCTGCAGCTGCGGGC
CTGGGACACCCAGCCAGCCCCGGCGGCTCTGAGGATGGGCCCCCAGGCTCGGAGGAGGAGGACGCGGCCCGGGAGGGGACACCGGGCTCA
CCCGGGCGAGGCAGAGAAGGGCCAGGAGAGGAGCACTTTGAGGACATGGCCTCCGACGAGGACATGGTGGAGAAAGGCAGTGAGGATGTG
CGGCTGATGAAACCCCCTTCTCCGGAACATCAGAGCCTTGATACACAACAGGAGGGCGGGGAGGAGGAGGTGGGCCCTGTGGCCCAGCAG
GCCATAGCTGTCGCAGAGCCCTCCACTTCCGAATGCCTCCGCATTGAGCCTGACACCACTGCCCTGAGCACCAATCACGAGACCATCGAC
CTGCTTGTCCAGATCCTCCGGAATTGTTTACGGTACTTCCTGCCTCCAAGTTTCCCCATCTCCAAGAAGCAGCTGAGTGCTATGAATTCA
GATGAGCTAATATCTTTTCCTCTGAAGGAGTACTTCAAGCAATATGAAGTAGGGCTCCAAAACCTGTGCAATTCCTACCAGAGCCGTGCT
GACTCCCGGGCCAAGGCCTCCGAGGAAAGCCTGCGCACCTCCGAGAGGAAGCTCCGCGAGACGGAGGAGAAGCTGCAGAAGCTGAGGACC
AACATCGTGGCACTCCTGCAAAAGGTGCAGGAGGACATAGACATCAACACAGATGATGAGCTGGACGCCTACATTGAGGACCTCATCACC
AAGGGGGACTGAAGGCAGGAGAGAGAGCAGCTCCCCTGCCCACCTGCCCCTCAACCCTGTAGCTGCAGGGGGAGGGGACTTCATTCATGG
GTTGGTGGTCGCACCTTGGTTTGACTTACACGGGACATTTGTGTTTTTGGAGGAAAAGATACCCTGATTCTTTGAATCTTCCTTAAGTTT
ATAAATATTTATTTTTTAAAAGAA

>6448_6448_3_ARID3A-MORC2_ARID3A_chr19_929896_ENST00000263620_MORC2_chr22_31328756_ENST00000215862_length(amino acids)=361AA_BP=170
MHCPGSPAAPTLQCGRAPSPQGPPPPPTPSARGGGGGGGGGGPGRRAMKLQAVMETLLQRQQRARQELEARQQLPPDPPAAPPGRARAAP
DEDREPESARMQRAQMAALAAMRAAAAGLGHPASPGGSEDGPPGSEEEDAAREGTPGSPGRGREGPGEEHFEDMASDEDMVEKGSEDVRL
MKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALSTNHETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDE
LISFPLKEYFKQYEVGLQNLCNSYQSRADSRAKASEESLRTSERKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKG
D

--------------------------------------------------------------
>6448_6448_4_ARID3A-MORC2_ARID3A_chr19_929896_ENST00000263620_MORC2_chr22_31328756_ENST00000397641_length(transcript)=2945nt_BP=695nt
GCGGGGCGCCTCTTACCAATCGGGCGGAGGGGTGTAGACGCGGACGCGGCTGGCGGCTCGGTTTCTGCAAATGCGTGAATGAGCCGGATG
CCAGCCTCTGTCCCCTGGAGCCCAGCGTGAGGAAGAGGCATGCCCCATCAGCCTTCAGCTTGAGCCCGGCGGCCCCCGCCCCCGCCCCCT
GCCACCCTGCACTGCCCCGGCTCCCCCGCGGCCCCCACGCTGCAGTGCGGCCGGGCCCCCTCCCCGCAGGGGCCGCCCCCGCCGCCCACC
CCTAGCGCCCGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGCCCGGGCCGCAGGGCCATGAAACTACAGGCCGTGATGGAGACGCTGTTG
CAGCGGCAGCAGCGGGCGCGCCAGGAGCTGGAGGCCCGGCAGCAGCTGCCCCCCGATCCCCCTGCTGCACCCCCCGGCCGGGCCCGGGCT
GCCCCCGACGAGGACAGAGAGCCCGAGAGTGCCCGGATGCAGCGGGCTCAGATGGCCGCACTGGCAGCCATGCGGGCTGCAGCTGCGGGC
CTGGGACACCCAGCCAGCCCCGGCGGCTCTGAGGATGGGCCCCCAGGCTCGGAGGAGGAGGACGCGGCCCGGGAGGGGACACCGGGCTCA
CCCGGGCGAGGCAGAGAAGGGCCAGGAGAGGAGCACTTTGAGGACATGGCCTCCGACGAGGACATGGTGGAGAAAGGCAGTGAGGATGTG
CGGCTGATGAAACCCCCTTCTCCGGAACATCAGAGCCTTGATACACAACAGGAGGGCGGGGAGGAGGAGGTGGGCCCTGTGGCCCAGCAG
GCCATAGCTGTCGCAGAGCCCTCCACTTCCGAATGCCTCCGCATTGAGCCTGACACCACTGCCCTGAGCACCAATCACGAGACCATCGAC
CTGCTTGTCCAGATCCTCCGGAATTGTTTACGGTACTTCCTGCCTCCAAGTTTCCCCATCTCCAAGAAGCAGCTGAGTGCTATGAATTCA
GATGAGCTAATATCTTTTCCTCTGAAGGAGTACTTCAAGCAATATGAAGTAGGGCTCCAAAACCTGTGCAATTCCTACCAGAGCCGTGCT
GACTCCCGGGCCAAGGCCTCCGAGGAAAGCCTGCGCACCTCCGAGAGGAAGCTCCGCGAGACGGAGGAGAAGCTGCAGAAGCTGAGGACC
AACATCGTGGCACTCCTGCAAAAGGTGCAGGAGGACATAGACATCAACACAGATGATGAGCTGGACGCCTACATTGAGGACCTCATCACC
AAGGGGGACTGAAGGCAGGAGAGAGAGCAGCTCCCCTGCCCACCTGCCCCTCAACCCTGTAGCTGCAGGGGGAGGGGACTTCATTCATGG
GTTGGTGGTCGCACCTTGGTTTGACTTACACGGGACATTTGTGTTTTTGGAGGAAAAGATACCCTGATTCTTTGAATCTTCCTTAAGTTT
ATAAATATTTATTTTTTAAAAGAAGATGCTGTGCCTGTGAGACCATACTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGTGAC
TGCAAAGGACAGAGAACCTTTCCACTTTGGCCATACTGGGTTGCTAAGCCGGAGCCATTTCAGCTCCTGGCTCCTCAAGATAACGGCGAG
TCCAGTGCCATCTTGGAGAAGCTCCAGGGGCAGGGCTGACTTTTCTCCTACAGGAGGAACAATGTGGGGATCTGAGGGATGGGAGGGAGA
CTTCCCCCTAGAGTGGTGGTCCTGCTGGGGGCTCATATCCAGGGACCCAAAAGGGGGGCTGTGTAGGAGGTTCCACATTGGAGGGGCTCT
CTCTCTCGCAGCTGTCAGAGTTGGTCCTGGCTGTGGCGTCCAAACAGCTTGAGGGAAAAAGATCCTGTCTAACCACCTCATCTACTACTC
AAGTTCTTTCTGAAGGAGGGATTTCTTCAGTTAACCATGGACAGTGAGGTTTCTCACCACAGTAACTTGAGTCCAGGTTGAGGGGGAGAC
AGATCTGTGGTAAATCTCTGACTTGGGCAGCACACTGAGTGTGGAACCCCACAGGACTCCTTAGGGAAGGAGCTTGTGTGTGAAAGAACC
CCTGGGGCTGAGCTGGTGACCTCCATGTGTGGGTGCAGCAGGGCCTTGGATGGTGCCAATTGATCTGGACAGCCTGTTGATGCTTTTCTA
CTTCCACCCTTCGGCCTGGCCCCACTGAGCCCCATCAAGGTGCCTGAAGAGGGGGCCAGTGAGATCCCGTGGCCACAGGGACTCCAGAGG
CATCTCTGCAGGAAGCACACCATGCCTTCCCTCCATGTTCCATCACGGCGCCACAATCTGTGTCCCTTAACTTCTCAGGGTCAAAGACAA
AGGCAAGCGTTGCTGAATTTTCTCTTTAATGGCCATTGGAAGAGTCTGGTTCAGTTTTTCCCAACTCTCTTCCCACTCGTATTTGGGGCC
TCTGGGTTTTCTGAAGGCACAAGGACTGTGACTTTGTACCACTAACCTGTGGTTCAAACCTGGGTGTGTTTCTGGCATCTCCCTAACCCA
GATCAGCAATGGCCACCCTGCTCCTCTGAGGTCAGCAGAAGACTGGGAAGCAGAGGTGAGGGATGCAGGCCACACTGGAATGGGAAGTCT
TTTCCCCACTGGATGTGCCTGTCTGGTGGGTTTTGGACCTTCCCAGACTACATCTCTAGGAGAGGCCTGTTTGGAGTAGTACACTGAGAG
ACCCTGGCCTCTTCTGCTGGAAGACTGTCCAAGTCTTGGGGTTTCTTGAGCTGGTGATTCCTCTGCCATCCTGCTCTCTCTCTTCATCTC
AGGCAGCATGGGGTCCACTTTTGTCCCCAAACCTAATGTTTTAATCCAAATGCAAATTGGTTCCACATTTTTACTGGAGGGTAATCAGTT
TTTAAAATTCACACACATGTAATCGAAACGCAATACTATAAAGTTCTACTGGTGAGACTCCTGAA

>6448_6448_4_ARID3A-MORC2_ARID3A_chr19_929896_ENST00000263620_MORC2_chr22_31328756_ENST00000397641_length(amino acids)=361AA_BP=170
MHCPGSPAAPTLQCGRAPSPQGPPPPPTPSARGGGGGGGGGGPGRRAMKLQAVMETLLQRQQRARQELEARQQLPPDPPAAPPGRARAAP
DEDREPESARMQRAQMAALAAMRAAAAGLGHPASPGGSEDGPPGSEEEDAAREGTPGSPGRGREGPGEEHFEDMASDEDMVEKGSEDVRL
MKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALSTNHETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDE
LISFPLKEYFKQYEVGLQNLCNSYQSRADSRAKASEESLRTSERKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKG
D

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARID3A-MORC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARID3A-MORC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARID3A-MORC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC4225243CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2Z5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0007959Charcot-Marie-Tooth Disease1CTD_human
TgeneC0205713Roussy-Levy Syndrome (disorder)1CTD_human
TgeneC0270911Charcot-Marie-Tooth Disease, Type Ia (disorder)1CTD_human
TgeneC0270912Charcot-Marie-Tooth Disease, Type Ib1CTD_human
TgeneC0270914Hereditary Motor and Sensory-Neuropathy Type II1CTD_human
TgeneC0751036Hereditary Motor and Sensory Neuropathy Type I1CTD_human