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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DSC3-RPS6 (FusionGDB2 ID:HG1825TG6194)

Fusion Gene Summary for DSC3-RPS6

check button Fusion gene summary
Fusion gene informationFusion gene name: DSC3-RPS6
Fusion gene ID: hg1825tg6194
HgeneTgene
Gene symbol

DSC3

RPS6

Gene ID

1825

6194

Gene namedesmocollin 3ribosomal protein S6
SynonymsCDHF3|DSC|DSC1|DSC2|DSC4|HT-CPS6
Cytomap('DSC3')('RPS6')

18q12.1

9p22.1

Type of geneprotein-codingprotein-coding
Descriptiondesmocollin-3cadherin family member 3desmocollin-440S ribosomal protein S6phosphoprotein NP33small ribosomal subunit protein eS6
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000360428, ENST00000434452, 
Fusion gene scores* DoF score6 X 7 X 4=16815 X 15 X 4=900
# samples 617
** MAII scorelog2(6/168*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/900*10)=-2.40439025507934
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DSC3 [Title/Abstract] AND RPS6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDSC3(28576756)-RPS6(19378916), # samples:1
DSC3(28576757)-RPS6(19378916), # samples:1
Anticipated loss of major functional domain due to fusion event.DSC3-RPS6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DSC3-RPS6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRPS6

GO:0031929

TOR signaling

16428328

TgeneRPS6

GO:0043065

positive regulation of apoptotic process

18362888


check buttonFusion gene breakpoints across DSC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RPS6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-IP-7968-11ADSC3chr18

28576756

-RPS6chr9

19378916

-
ChimerDB4Non-CancerTCGA-IP-7968-11ADSC3chr18

28576757

-RPS6chr9

19378916

-


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Fusion Gene ORF analysis for DSC3-RPS6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000360428ENST00000380381DSC3chr18

28576756

-RPS6chr9

19378916

-
5CDS-3UTRENST00000360428ENST00000380381DSC3chr18

28576757

-RPS6chr9

19378916

-
5CDS-3UTRENST00000434452ENST00000380381DSC3chr18

28576756

-RPS6chr9

19378916

-
5CDS-3UTRENST00000434452ENST00000380381DSC3chr18

28576757

-RPS6chr9

19378916

-
5CDS-intronENST00000360428ENST00000315377DSC3chr18

28576756

-RPS6chr9

19378916

-
5CDS-intronENST00000360428ENST00000315377DSC3chr18

28576757

-RPS6chr9

19378916

-
5CDS-intronENST00000360428ENST00000380384DSC3chr18

28576756

-RPS6chr9

19378916

-
5CDS-intronENST00000360428ENST00000380384DSC3chr18

28576757

-RPS6chr9

19378916

-
5CDS-intronENST00000360428ENST00000498815DSC3chr18

28576756

-RPS6chr9

19378916

-
5CDS-intronENST00000360428ENST00000498815DSC3chr18

28576757

-RPS6chr9

19378916

-
5CDS-intronENST00000434452ENST00000315377DSC3chr18

28576756

-RPS6chr9

19378916

-
5CDS-intronENST00000434452ENST00000315377DSC3chr18

28576757

-RPS6chr9

19378916

-
5CDS-intronENST00000434452ENST00000380384DSC3chr18

28576756

-RPS6chr9

19378916

-
5CDS-intronENST00000434452ENST00000380384DSC3chr18

28576757

-RPS6chr9

19378916

-
5CDS-intronENST00000434452ENST00000498815DSC3chr18

28576756

-RPS6chr9

19378916

-
5CDS-intronENST00000434452ENST00000498815DSC3chr18

28576757

-RPS6chr9

19378916

-
In-frameENST00000360428ENST00000380394DSC3chr18

28576756

-RPS6chr9

19378916

-
In-frameENST00000360428ENST00000380394DSC3chr18

28576757

-RPS6chr9

19378916

-
In-frameENST00000434452ENST00000380394DSC3chr18

28576756

-RPS6chr9

19378916

-
In-frameENST00000434452ENST00000380394DSC3chr18

28576757

-RPS6chr9

19378916

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360428DSC3chr1828576756-ENST00000380394RPS6chr919378916-37642574931851058
ENST00000434452DSC3chr1828576756-ENST00000380394RPS6chr919378916-383826488332591058
ENST00000360428DSC3chr1828576757-ENST00000380394RPS6chr919378916-37642574931851058
ENST00000434452DSC3chr1828576757-ENST00000380394RPS6chr919378916-383826488332591058

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360428ENST00000380394DSC3chr1828576756-RPS6chr919378916-0.000316290.99968374
ENST00000434452ENST00000380394DSC3chr1828576756-RPS6chr919378916-0.0003783980.9996216
ENST00000360428ENST00000380394DSC3chr1828576757-RPS6chr919378916-0.000316290.99968374
ENST00000434452ENST00000380394DSC3chr1828576757-RPS6chr919378916-0.0003783980.9996216

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Fusion Genomic Features for DSC3-RPS6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for DSC3-RPS6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:28576756/chr9:19378916)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDSC3chr18:28576756chr9:19378916ENST00000360428-1516136_243831897.0DomainCadherin 1
HgeneDSC3chr18:28576756chr9:19378916ENST00000360428-1516244_355831897.0DomainCadherin 2
HgeneDSC3chr18:28576756chr9:19378916ENST00000360428-1516356_471831897.0DomainCadherin 3
HgeneDSC3chr18:28576756chr9:19378916ENST00000360428-1516472_579831897.0DomainCadherin 4
HgeneDSC3chr18:28576756chr9:19378916ENST00000360428-1516580_690831897.0DomainCadherin 5
HgeneDSC3chr18:28576756chr9:19378916ENST00000434452-1517136_2438312180.3333333333335DomainCadherin 1
HgeneDSC3chr18:28576756chr9:19378916ENST00000434452-1517244_3558312180.3333333333335DomainCadherin 2
HgeneDSC3chr18:28576756chr9:19378916ENST00000434452-1517356_4718312180.3333333333335DomainCadherin 3
HgeneDSC3chr18:28576756chr9:19378916ENST00000434452-1517472_5798312180.3333333333335DomainCadherin 4
HgeneDSC3chr18:28576756chr9:19378916ENST00000434452-1517580_6908312180.3333333333335DomainCadherin 5
HgeneDSC3chr18:28576757chr9:19378916ENST00000360428-1516136_243831897.0DomainCadherin 1
HgeneDSC3chr18:28576757chr9:19378916ENST00000360428-1516244_355831897.0DomainCadherin 2
HgeneDSC3chr18:28576757chr9:19378916ENST00000360428-1516356_471831897.0DomainCadherin 3
HgeneDSC3chr18:28576757chr9:19378916ENST00000360428-1516472_579831897.0DomainCadherin 4
HgeneDSC3chr18:28576757chr9:19378916ENST00000360428-1516580_690831897.0DomainCadherin 5
HgeneDSC3chr18:28576757chr9:19378916ENST00000434452-1517136_2438312180.3333333333335DomainCadherin 1
HgeneDSC3chr18:28576757chr9:19378916ENST00000434452-1517244_3558312180.3333333333335DomainCadherin 2
HgeneDSC3chr18:28576757chr9:19378916ENST00000434452-1517356_4718312180.3333333333335DomainCadherin 3
HgeneDSC3chr18:28576757chr9:19378916ENST00000434452-1517472_5798312180.3333333333335DomainCadherin 4
HgeneDSC3chr18:28576757chr9:19378916ENST00000434452-1517580_6908312180.3333333333335DomainCadherin 5
HgeneDSC3chr18:28576756chr9:19378916ENST00000360428-1516136_690831897.0Topological domainExtracellular
HgeneDSC3chr18:28576756chr9:19378916ENST00000434452-1517136_6908312180.3333333333335Topological domainExtracellular
HgeneDSC3chr18:28576757chr9:19378916ENST00000360428-1516136_690831897.0Topological domainExtracellular
HgeneDSC3chr18:28576757chr9:19378916ENST00000434452-1517136_6908312180.3333333333335Topological domainExtracellular
HgeneDSC3chr18:28576756chr9:19378916ENST00000360428-1516691_711831897.0TransmembraneHelical
HgeneDSC3chr18:28576756chr9:19378916ENST00000434452-1517691_7118312180.3333333333335TransmembraneHelical
HgeneDSC3chr18:28576757chr9:19378916ENST00000360428-1516691_711831897.0TransmembraneHelical
HgeneDSC3chr18:28576757chr9:19378916ENST00000434452-1517691_7118312180.3333333333335TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDSC3chr18:28576756chr9:19378916ENST00000360428-1516712_896831897.0Topological domainCytoplasmic
HgeneDSC3chr18:28576756chr9:19378916ENST00000434452-1517712_8968312180.3333333333335Topological domainCytoplasmic
HgeneDSC3chr18:28576757chr9:19378916ENST00000360428-1516712_896831897.0Topological domainCytoplasmic
HgeneDSC3chr18:28576757chr9:19378916ENST00000434452-1517712_8968312180.3333333333335Topological domainCytoplasmic


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Fusion Gene Sequence for DSC3-RPS6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24188_24188_1_DSC3-RPS6_DSC3_chr18_28576756_ENST00000360428_RPS6_chr9_19378916_ENST00000380394_length(transcript)=3764nt_BP=2574nt
TCCCGCGCCCTGCACCTCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCC
GCTGGGCCCCGGCGCTCCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAA
AAGGTGATACTTAATGTACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTC
ATCCGGTCAAGTGATCCTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCA
TTTACCATATGGCTTTCTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGA
CACACTAGAGAAACTGTTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCA
TTGTTTCTTCAACAAGTTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTA
AATTTGTTTTATATAGAAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCT
TATGCGTCAACTGCAGATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTC
ACAGAAGCAATTTATAATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCG
GACACAATGCATACGCGCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTA
ATCACCACAGTCTCTCATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTT
GGATTGATAGGCACATCAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTT
GTAGAGGAAAATGCATTCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTT
ACCATTTTAAAGGGAAATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGCCACTG
AATTATGAAGAAAACCGTCAAGTGAACCTGGAAATTGGAGTAAACAATGAAGCGCCATTTGCTAGAGATATTCCCAGAGTGACAGCCTTG
AACAGAGCCTTGGTTACAGTTCATGTGAGGGATCTGGATGAGGGGCCTGAATGCACTCCTGCAGCCCAATATGTGCGGATTAAAGAAAAC
TTAGCAGTGGGGTCAAAGATCAACGGCTATAAGGCATATGACCCCGAAAATAGAAATGGCAATGGTTTAAGGTACAAAAAATTGCATGAT
CCTAAAGGTTGGATCACCATTGATGAAATTTCAGGGTCAATCATAACTTCCAAAATCCTGGATAGGGAGGTTGAAACTCCCAAAAATGAG
TTGTATAATATTACAGTCCTGGCAATAGACAAAGATGATAGATCATGTACTGGAACACTTGCTGTGAACATTGAAGATGTAAATGATAAT
CCACCAGAAATACTTCAAGAATATGTAGTCATTTGCAAACCAAAAATGGGGTATACCGACATTTTAGCTGTTGATCCTGATGAACCTGTC
CATGGAGCTCCATTTTATTTCAGTTTGCCCAATACTTCTCCAGAAATCAGTAGACTGTGGAGCCTCACCAAAGTTAATGATACAGCTGCC
CGTCTTTCATATCAGAAAAATGCTGGATTTCAAGAATATACCATTCCTATTACTGTAAAAGACAGGGCCGGCCAAGCTGCAACAAAATTA
TTGAGAGTTAATCTGTGTGAATGTACTCATCCAACTCAGTGTCGTGCGACTTCAAGGAGTACAGGAGTAATACTTGGAAAATGGGCAATC
CTTGCAATATTACTGGGTATAGCACTGCTCTTTTCTGTATTGCTAACTTTAGTATGTGGAGTTTTTGGTGCAACTAAAGGGAAACGTTTT
CCTGAAGATTTAGCACAGCAAAACTTAATTATATCAAACACAGAAGCACCTGGAGACGATAGAGTGTGCTCTGCCAATGGATTTATGACC
CAAACTACCAACAACTCTAGCCAAGGTTTTTGTGGTACTATGGGATCAGGAATGAAAAATGGAGGGCAGGAAACCATTGAAATGATGAAA
GGAGGAAACCAGACCTTGGAATCCTGCCGGGGGGCTGGGCATCATCATACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGACAAC
TGCAGATACACTTACTCGGAGTGGCACAGTTTTACTCAACCCCGTCTCGGTGAAGGTTATGTGGTCCGAATCAGTGGTGGGAACGACAAA
CAAGGTTTCCCCATGAAGCAGGGTGTCTTGACCCATGGCCGTGTCCGCCTGCTACTGAGTAAGGGGCATTCCTGTTACAGACCAAGGAGA
ACTGGAGAAAGAAAGAGAAAATCAGTTCGTGGTTGCATTGTGGATGCAAATCTGAGCGTTCTCAACTTGGTTATTGTAAAAAAAGGAGAG
AAGGATATTCCTGGACTGACTGATACTACAGTGCCTCGCCGCCTGGGCCCCAAAAGAGCTAGCAGAATCCGCAAACTTTTCAATCTCTCT
AAAGAAGATGATGTCCGCCAGTATGTTGTAAGAAAGCCCTTAAATAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGT
CTTGTTACTCCACGTGTCCTGCAGCACAAACGGCGGCGTATTGCTCTGAAGAAGCAGCGTACCAAGAAAAATAAAGAAGAGGCTGCAGAA
TATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGGAGAAGCGCCAGGAACAAATTGCGAAGAGACGCAGACTTTCCTCTCTGCGA
GCTTCTACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAATAAGATCAGACTCTGATCTCTGTTGACTTTTC
ATTGCTGATAGAAAACTACATAAATGAAGAGAGGGAAAGTTAGGTCATAGAAAATGGGGATATGTATATATGGTATTCCAATGGTGGATA
AAGTCAGACCTATTGTGTGTGGTAGTGGAAGACAAGGTCAGTGTACAGGGGTTCCTTTCAGGGGATGGGTGGCACAGGAAGGGATTCTGA
GCATAAGACACCTGCCTCTTCAGAATGGCATGGAACTTAGGGGAAATGATGAGGACTATTAATCTTTTTTATATAGTTTATTTTTGAGGA
ATATAGCTCTTTAAAGCACTATACACAATTTAATACATGAAAATTGACCTTGTGAAGATGAACATGTCTTTTTTAAAAGGTAACTTTTAA
GGCATAGTTTTAGTGGATACCTAGTTTTAGTGGATACCATCCACTAAATGGTTTTTAAGCCATTTCAAATTTGTTTTAACAAAGCTTTTC
AACTCCAGTGAATTGTTAGGCTGTTCACACACTGAAAAGGAAATGACTAAAAACATTCTTGGATCAGTGAAAAA

>24188_24188_1_DSC3-RPS6_DSC3_chr18_28576756_ENST00000360428_RPS6_chr9_19378916_ENST00000380394_length(amino acids)=1058AA_BP=855
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYE
ENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKG
WITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGA
PFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAI
LLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGN
QTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGE
RKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVT
PRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK

--------------------------------------------------------------
>24188_24188_2_DSC3-RPS6_DSC3_chr18_28576756_ENST00000434452_RPS6_chr9_19378916_ENST00000380394_length(transcript)=3838nt_BP=2648nt
GAAGTTGCTCCCGGGCAGGCAAGCCTGAGAGAGGCCAAATACACTTAAAAACAAGCAGCGGCGAGAAAAGCACCTCCCGCGCCCTGCACC
TCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCCGCTGGGCCCCGGCGCT
CCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAAAAGGTGATACTTAATG
TACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTCATCCGGTCAAGTGATC
CTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCATTTACCATATGGCTTT
CTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGACACACTAGAGAAACTG
TTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCATTGTTTCTTCAACAAG
TTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTAAATTTGTTTTATATAG
AAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCTTATGCGTCAACTGCAG
ATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTCACAGAAGCAATTTATA
ATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCGGACACAATGCATACGC
GCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTAATCACCACAGTCTCTC
ATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTTGGATTGATAGGCACAT
CAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTTGTAGAGGAAAATGCAT
TCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTTACCATTTTAAAGGGAA
ATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGCCACTGAATTATGAAGAAAACC
GTCAAGTGAACCTGGAAATTGGAGTAAACAATGAAGCGCCATTTGCTAGAGATATTCCCAGAGTGACAGCCTTGAACAGAGCCTTGGTTA
CAGTTCATGTGAGGGATCTGGATGAGGGGCCTGAATGCACTCCTGCAGCCCAATATGTGCGGATTAAAGAAAACTTAGCAGTGGGGTCAA
AGATCAACGGCTATAAGGCATATGACCCCGAAAATAGAAATGGCAATGGTTTAAGGTACAAAAAATTGCATGATCCTAAAGGTTGGATCA
CCATTGATGAAATTTCAGGGTCAATCATAACTTCCAAAATCCTGGATAGGGAGGTTGAAACTCCCAAAAATGAGTTGTATAATATTACAG
TCCTGGCAATAGACAAAGATGATAGATCATGTACTGGAACACTTGCTGTGAACATTGAAGATGTAAATGATAATCCACCAGAAATACTTC
AAGAATATGTAGTCATTTGCAAACCAAAAATGGGGTATACCGACATTTTAGCTGTTGATCCTGATGAACCTGTCCATGGAGCTCCATTTT
ATTTCAGTTTGCCCAATACTTCTCCAGAAATCAGTAGACTGTGGAGCCTCACCAAAGTTAATGATACAGCTGCCCGTCTTTCATATCAGA
AAAATGCTGGATTTCAAGAATATACCATTCCTATTACTGTAAAAGACAGGGCCGGCCAAGCTGCAACAAAATTATTGAGAGTTAATCTGT
GTGAATGTACTCATCCAACTCAGTGTCGTGCGACTTCAAGGAGTACAGGAGTAATACTTGGAAAATGGGCAATCCTTGCAATATTACTGG
GTATAGCACTGCTCTTTTCTGTATTGCTAACTTTAGTATGTGGAGTTTTTGGTGCAACTAAAGGGAAACGTTTTCCTGAAGATTTAGCAC
AGCAAAACTTAATTATATCAAACACAGAAGCACCTGGAGACGATAGAGTGTGCTCTGCCAATGGATTTATGACCCAAACTACCAACAACT
CTAGCCAAGGTTTTTGTGGTACTATGGGATCAGGAATGAAAAATGGAGGGCAGGAAACCATTGAAATGATGAAAGGAGGAAACCAGACCT
TGGAATCCTGCCGGGGGGCTGGGCATCATCATACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGACAACTGCAGATACACTTACT
CGGAGTGGCACAGTTTTACTCAACCCCGTCTCGGTGAAGGTTATGTGGTCCGAATCAGTGGTGGGAACGACAAACAAGGTTTCCCCATGA
AGCAGGGTGTCTTGACCCATGGCCGTGTCCGCCTGCTACTGAGTAAGGGGCATTCCTGTTACAGACCAAGGAGAACTGGAGAAAGAAAGA
GAAAATCAGTTCGTGGTTGCATTGTGGATGCAAATCTGAGCGTTCTCAACTTGGTTATTGTAAAAAAAGGAGAGAAGGATATTCCTGGAC
TGACTGATACTACAGTGCCTCGCCGCCTGGGCCCCAAAAGAGCTAGCAGAATCCGCAAACTTTTCAATCTCTCTAAAGAAGATGATGTCC
GCCAGTATGTTGTAAGAAAGCCCTTAAATAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGTCTTGTTACTCCACGTG
TCCTGCAGCACAAACGGCGGCGTATTGCTCTGAAGAAGCAGCGTACCAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGG
CCAAGAGAATGAAGGAGGCTAAGGAGAAGCGCCAGGAACAAATTGCGAAGAGACGCAGACTTTCCTCTCTGCGAGCTTCTACTTCTAAGT
CTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAATAAGATCAGACTCTGATCTCTGTTGACTTTTCATTGCTGATAGAAAAC
TACATAAATGAAGAGAGGGAAAGTTAGGTCATAGAAAATGGGGATATGTATATATGGTATTCCAATGGTGGATAAAGTCAGACCTATTGT
GTGTGGTAGTGGAAGACAAGGTCAGTGTACAGGGGTTCCTTTCAGGGGATGGGTGGCACAGGAAGGGATTCTGAGCATAAGACACCTGCC
TCTTCAGAATGGCATGGAACTTAGGGGAAATGATGAGGACTATTAATCTTTTTTATATAGTTTATTTTTGAGGAATATAGCTCTTTAAAG
CACTATACACAATTTAATACATGAAAATTGACCTTGTGAAGATGAACATGTCTTTTTTAAAAGGTAACTTTTAAGGCATAGTTTTAGTGG
ATACCTAGTTTTAGTGGATACCATCCACTAAATGGTTTTTAAGCCATTTCAAATTTGTTTTAACAAAGCTTTTCAACTCCAGTGAATTGT
TAGGCTGTTCACACACTGAAAAGGAAATGACTAAAAACATTCTTGGATCAGTGAAAAA

>24188_24188_2_DSC3-RPS6_DSC3_chr18_28576756_ENST00000434452_RPS6_chr9_19378916_ENST00000380394_length(amino acids)=1058AA_BP=855
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYE
ENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKG
WITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGA
PFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAI
LLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGN
QTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGE
RKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVT
PRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK

--------------------------------------------------------------
>24188_24188_3_DSC3-RPS6_DSC3_chr18_28576757_ENST00000360428_RPS6_chr9_19378916_ENST00000380394_length(transcript)=3764nt_BP=2574nt
TCCCGCGCCCTGCACCTCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCC
GCTGGGCCCCGGCGCTCCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAA
AAGGTGATACTTAATGTACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTC
ATCCGGTCAAGTGATCCTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCA
TTTACCATATGGCTTTCTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGA
CACACTAGAGAAACTGTTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCA
TTGTTTCTTCAACAAGTTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTA
AATTTGTTTTATATAGAAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCT
TATGCGTCAACTGCAGATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTC
ACAGAAGCAATTTATAATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCG
GACACAATGCATACGCGCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTA
ATCACCACAGTCTCTCATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTT
GGATTGATAGGCACATCAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTT
GTAGAGGAAAATGCATTCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTT
ACCATTTTAAAGGGAAATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGCCACTG
AATTATGAAGAAAACCGTCAAGTGAACCTGGAAATTGGAGTAAACAATGAAGCGCCATTTGCTAGAGATATTCCCAGAGTGACAGCCTTG
AACAGAGCCTTGGTTACAGTTCATGTGAGGGATCTGGATGAGGGGCCTGAATGCACTCCTGCAGCCCAATATGTGCGGATTAAAGAAAAC
TTAGCAGTGGGGTCAAAGATCAACGGCTATAAGGCATATGACCCCGAAAATAGAAATGGCAATGGTTTAAGGTACAAAAAATTGCATGAT
CCTAAAGGTTGGATCACCATTGATGAAATTTCAGGGTCAATCATAACTTCCAAAATCCTGGATAGGGAGGTTGAAACTCCCAAAAATGAG
TTGTATAATATTACAGTCCTGGCAATAGACAAAGATGATAGATCATGTACTGGAACACTTGCTGTGAACATTGAAGATGTAAATGATAAT
CCACCAGAAATACTTCAAGAATATGTAGTCATTTGCAAACCAAAAATGGGGTATACCGACATTTTAGCTGTTGATCCTGATGAACCTGTC
CATGGAGCTCCATTTTATTTCAGTTTGCCCAATACTTCTCCAGAAATCAGTAGACTGTGGAGCCTCACCAAAGTTAATGATACAGCTGCC
CGTCTTTCATATCAGAAAAATGCTGGATTTCAAGAATATACCATTCCTATTACTGTAAAAGACAGGGCCGGCCAAGCTGCAACAAAATTA
TTGAGAGTTAATCTGTGTGAATGTACTCATCCAACTCAGTGTCGTGCGACTTCAAGGAGTACAGGAGTAATACTTGGAAAATGGGCAATC
CTTGCAATATTACTGGGTATAGCACTGCTCTTTTCTGTATTGCTAACTTTAGTATGTGGAGTTTTTGGTGCAACTAAAGGGAAACGTTTT
CCTGAAGATTTAGCACAGCAAAACTTAATTATATCAAACACAGAAGCACCTGGAGACGATAGAGTGTGCTCTGCCAATGGATTTATGACC
CAAACTACCAACAACTCTAGCCAAGGTTTTTGTGGTACTATGGGATCAGGAATGAAAAATGGAGGGCAGGAAACCATTGAAATGATGAAA
GGAGGAAACCAGACCTTGGAATCCTGCCGGGGGGCTGGGCATCATCATACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGACAAC
TGCAGATACACTTACTCGGAGTGGCACAGTTTTACTCAACCCCGTCTCGGTGAAGGTTATGTGGTCCGAATCAGTGGTGGGAACGACAAA
CAAGGTTTCCCCATGAAGCAGGGTGTCTTGACCCATGGCCGTGTCCGCCTGCTACTGAGTAAGGGGCATTCCTGTTACAGACCAAGGAGA
ACTGGAGAAAGAAAGAGAAAATCAGTTCGTGGTTGCATTGTGGATGCAAATCTGAGCGTTCTCAACTTGGTTATTGTAAAAAAAGGAGAG
AAGGATATTCCTGGACTGACTGATACTACAGTGCCTCGCCGCCTGGGCCCCAAAAGAGCTAGCAGAATCCGCAAACTTTTCAATCTCTCT
AAAGAAGATGATGTCCGCCAGTATGTTGTAAGAAAGCCCTTAAATAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGT
CTTGTTACTCCACGTGTCCTGCAGCACAAACGGCGGCGTATTGCTCTGAAGAAGCAGCGTACCAAGAAAAATAAAGAAGAGGCTGCAGAA
TATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGGAGAAGCGCCAGGAACAAATTGCGAAGAGACGCAGACTTTCCTCTCTGCGA
GCTTCTACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAATAAGATCAGACTCTGATCTCTGTTGACTTTTC
ATTGCTGATAGAAAACTACATAAATGAAGAGAGGGAAAGTTAGGTCATAGAAAATGGGGATATGTATATATGGTATTCCAATGGTGGATA
AAGTCAGACCTATTGTGTGTGGTAGTGGAAGACAAGGTCAGTGTACAGGGGTTCCTTTCAGGGGATGGGTGGCACAGGAAGGGATTCTGA
GCATAAGACACCTGCCTCTTCAGAATGGCATGGAACTTAGGGGAAATGATGAGGACTATTAATCTTTTTTATATAGTTTATTTTTGAGGA
ATATAGCTCTTTAAAGCACTATACACAATTTAATACATGAAAATTGACCTTGTGAAGATGAACATGTCTTTTTTAAAAGGTAACTTTTAA
GGCATAGTTTTAGTGGATACCTAGTTTTAGTGGATACCATCCACTAAATGGTTTTTAAGCCATTTCAAATTTGTTTTAACAAAGCTTTTC
AACTCCAGTGAATTGTTAGGCTGTTCACACACTGAAAAGGAAATGACTAAAAACATTCTTGGATCAGTGAAAAA

>24188_24188_3_DSC3-RPS6_DSC3_chr18_28576757_ENST00000360428_RPS6_chr9_19378916_ENST00000380394_length(amino acids)=1058AA_BP=855
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYE
ENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKG
WITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGA
PFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAI
LLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGN
QTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGE
RKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVT
PRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK

--------------------------------------------------------------
>24188_24188_4_DSC3-RPS6_DSC3_chr18_28576757_ENST00000434452_RPS6_chr9_19378916_ENST00000380394_length(transcript)=3838nt_BP=2648nt
GAAGTTGCTCCCGGGCAGGCAAGCCTGAGAGAGGCCAAATACACTTAAAAACAAGCAGCGGCGAGAAAAGCACCTCCCGCGCCCTGCACC
TCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCCGCTGGGCCCCGGCGCT
CCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAAAAGGTGATACTTAATG
TACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTCATCCGGTCAAGTGATC
CTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCATTTACCATATGGCTTT
CTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGACACACTAGAGAAACTG
TTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCATTGTTTCTTCAACAAG
TTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTAAATTTGTTTTATATAG
AAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCTTATGCGTCAACTGCAG
ATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTCACAGAAGCAATTTATA
ATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCGGACACAATGCATACGC
GCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTAATCACCACAGTCTCTC
ATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTTGGATTGATAGGCACAT
CAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTTGTAGAGGAAAATGCAT
TCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTTACCATTTTAAAGGGAA
ATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGCCACTGAATTATGAAGAAAACC
GTCAAGTGAACCTGGAAATTGGAGTAAACAATGAAGCGCCATTTGCTAGAGATATTCCCAGAGTGACAGCCTTGAACAGAGCCTTGGTTA
CAGTTCATGTGAGGGATCTGGATGAGGGGCCTGAATGCACTCCTGCAGCCCAATATGTGCGGATTAAAGAAAACTTAGCAGTGGGGTCAA
AGATCAACGGCTATAAGGCATATGACCCCGAAAATAGAAATGGCAATGGTTTAAGGTACAAAAAATTGCATGATCCTAAAGGTTGGATCA
CCATTGATGAAATTTCAGGGTCAATCATAACTTCCAAAATCCTGGATAGGGAGGTTGAAACTCCCAAAAATGAGTTGTATAATATTACAG
TCCTGGCAATAGACAAAGATGATAGATCATGTACTGGAACACTTGCTGTGAACATTGAAGATGTAAATGATAATCCACCAGAAATACTTC
AAGAATATGTAGTCATTTGCAAACCAAAAATGGGGTATACCGACATTTTAGCTGTTGATCCTGATGAACCTGTCCATGGAGCTCCATTTT
ATTTCAGTTTGCCCAATACTTCTCCAGAAATCAGTAGACTGTGGAGCCTCACCAAAGTTAATGATACAGCTGCCCGTCTTTCATATCAGA
AAAATGCTGGATTTCAAGAATATACCATTCCTATTACTGTAAAAGACAGGGCCGGCCAAGCTGCAACAAAATTATTGAGAGTTAATCTGT
GTGAATGTACTCATCCAACTCAGTGTCGTGCGACTTCAAGGAGTACAGGAGTAATACTTGGAAAATGGGCAATCCTTGCAATATTACTGG
GTATAGCACTGCTCTTTTCTGTATTGCTAACTTTAGTATGTGGAGTTTTTGGTGCAACTAAAGGGAAACGTTTTCCTGAAGATTTAGCAC
AGCAAAACTTAATTATATCAAACACAGAAGCACCTGGAGACGATAGAGTGTGCTCTGCCAATGGATTTATGACCCAAACTACCAACAACT
CTAGCCAAGGTTTTTGTGGTACTATGGGATCAGGAATGAAAAATGGAGGGCAGGAAACCATTGAAATGATGAAAGGAGGAAACCAGACCT
TGGAATCCTGCCGGGGGGCTGGGCATCATCATACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGACAACTGCAGATACACTTACT
CGGAGTGGCACAGTTTTACTCAACCCCGTCTCGGTGAAGGTTATGTGGTCCGAATCAGTGGTGGGAACGACAAACAAGGTTTCCCCATGA
AGCAGGGTGTCTTGACCCATGGCCGTGTCCGCCTGCTACTGAGTAAGGGGCATTCCTGTTACAGACCAAGGAGAACTGGAGAAAGAAAGA
GAAAATCAGTTCGTGGTTGCATTGTGGATGCAAATCTGAGCGTTCTCAACTTGGTTATTGTAAAAAAAGGAGAGAAGGATATTCCTGGAC
TGACTGATACTACAGTGCCTCGCCGCCTGGGCCCCAAAAGAGCTAGCAGAATCCGCAAACTTTTCAATCTCTCTAAAGAAGATGATGTCC
GCCAGTATGTTGTAAGAAAGCCCTTAAATAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGTCTTGTTACTCCACGTG
TCCTGCAGCACAAACGGCGGCGTATTGCTCTGAAGAAGCAGCGTACCAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGG
CCAAGAGAATGAAGGAGGCTAAGGAGAAGCGCCAGGAACAAATTGCGAAGAGACGCAGACTTTCCTCTCTGCGAGCTTCTACTTCTAAGT
CTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAATAAGATCAGACTCTGATCTCTGTTGACTTTTCATTGCTGATAGAAAAC
TACATAAATGAAGAGAGGGAAAGTTAGGTCATAGAAAATGGGGATATGTATATATGGTATTCCAATGGTGGATAAAGTCAGACCTATTGT
GTGTGGTAGTGGAAGACAAGGTCAGTGTACAGGGGTTCCTTTCAGGGGATGGGTGGCACAGGAAGGGATTCTGAGCATAAGACACCTGCC
TCTTCAGAATGGCATGGAACTTAGGGGAAATGATGAGGACTATTAATCTTTTTTATATAGTTTATTTTTGAGGAATATAGCTCTTTAAAG
CACTATACACAATTTAATACATGAAAATTGACCTTGTGAAGATGAACATGTCTTTTTTAAAAGGTAACTTTTAAGGCATAGTTTTAGTGG
ATACCTAGTTTTAGTGGATACCATCCACTAAATGGTTTTTAAGCCATTTCAAATTTGTTTTAACAAAGCTTTTCAACTCCAGTGAATTGT
TAGGCTGTTCACACACTGAAAAGGAAATGACTAAAAACATTCTTGGATCAGTGAAAAA

>24188_24188_4_DSC3-RPS6_DSC3_chr18_28576757_ENST00000434452_RPS6_chr9_19378916_ENST00000380394_length(amino acids)=1058AA_BP=855
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYE
ENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKG
WITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGA
PFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAI
LLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGN
QTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGE
RKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVT
PRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DSC3-RPS6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DSC3-RPS6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DSC3-RPS6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDSC3C0006142Malignant neoplasm of breast1CTD_human
HgeneDSC3C0678222Breast Carcinoma1CTD_human
HgeneDSC3C1257931Mammary Neoplasms, Human1CTD_human
HgeneDSC3C1458155Mammary Neoplasms1CTD_human
HgeneDSC3C2751292Hypotrichosis And Recurrent Skin Vesicles1CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneDSC3C4704874Mammary Carcinoma, Human1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0024623Malignant neoplasm of stomach1CTD_human
TgeneC0038356Stomach Neoplasms1CTD_human
TgeneC0235874Disease Exacerbation1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneC2239176Liver carcinoma1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human