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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DSG1-TNXB (FusionGDB2 ID:HG1828TG7148)

Fusion Gene Summary for DSG1-TNXB

check button Fusion gene summary
Fusion gene informationFusion gene name: DSG1-TNXB
Fusion gene ID: hg1828tg7148
HgeneTgene
Gene symbol

DSG1

TNXB

Gene ID

1828

7148

Gene namedesmoglein 1tenascin XB
SynonymsCDHF4|DG1|DSG|EPKHE|EPKHIA|PPKS1|SPPK1EDS3|EDSCLL|EDSCLL1|HXBL|TENX|TN-X|TNX|TNXB1|TNXB2|TNXBS|VUR8|XB|XBS
Cytomap('DSG1')('TNXB')

18q12.1

6p21.33-p21.32

Type of geneprotein-codingprotein-coding
Descriptiondesmoglein-1cadherin family member 4desmosomal glycoprotein 1pemphigus foliaceus antigentenascin-Xgrowth-inhibiting protein 45hexabrachion-like proteintenascin XB1tenascin XB2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000257192, ENST00000462981, 
Fusion gene scores* DoF score4 X 4 X 3=486 X 6 X 5=180
# samples 47
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DSG1 [Title/Abstract] AND TNXB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDSG1(28919988)-TNXB(32038191), # samples:3
Anticipated loss of major functional domain due to fusion event.DSG1-TNXB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DSG1-TNXB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DSG1-TNXB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DSG1-TNXB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDSG1

GO:0050821

protein stabilization

7983064


check buttonFusion gene breakpoints across DSG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TNXB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A922-01ADSG1chr18

28919988

+TNXBchr6

32038191

-
ChimerDB4STADTCGA-VQ-A922DSG1chr18

28919988

+TNXBchr6

32038191

-


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Fusion Gene ORF analysis for DSG1-TNXB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000257192ENST00000375247DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000383159DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000424718DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000433037DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000440248DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000451343DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000464376DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000465958DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000469250DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000471059DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000475986DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000479795DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000489006DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000546684DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000548628DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000548649DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000549232DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000549652DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000550212DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000550539DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000551201DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000551808DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000552149DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000552665DSG1chr18

28919988

+TNXBchr6

32038191

-
5CDS-intronENST00000257192ENST00000553092DSG1chr18

28919988

+TNXBchr6

32038191

-
In-frameENST00000257192ENST00000375244DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-3CDSENST00000462981ENST00000375244DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000375247DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000383159DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000424718DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000433037DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000440248DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000451343DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000464376DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000465958DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000469250DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000471059DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000475986DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000479795DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000489006DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000546684DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000548628DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000548649DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000549232DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000549652DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000550212DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000550539DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000551201DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000551808DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000552149DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000552665DSG1chr18

28919988

+TNXBchr6

32038191

-
intron-intronENST00000462981ENST00000553092DSG1chr18

28919988

+TNXBchr6

32038191

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000257192DSG1chr1828919988+ENST00000375244TNXBchr632038191-9839189921296433143

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000257192ENST00000375244DSG1chr1828919988+TNXBchr632038191-0.0012674290.9987326

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Fusion Genomic Features for DSG1-TNXB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for DSG1-TNXB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:28919988/chr6:32038191)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115159_2705621050.0DomainCadherin 2
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115271_3855621050.0DomainCadherin 3
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115386_4975621050.0DomainCadherin 4
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+111550_1585621050.0DomainCadherin 1
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+111550_5485621050.0Topological domainExtracellular
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441674_176416634243.0DomainFibronectin type-III 8
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441778_186816634243.0DomainFibronectin type-III 9
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441883_197116634243.0DomainFibronectin type-III 10
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441989_208916634243.0DomainFibronectin type-III 11
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712442097_218516634243.0DomainFibronectin type-III 12
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712442196_229616634243.0DomainFibronectin type-III 13
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712442305_239816634243.0DomainFibronectin type-III 14
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712442408_250216634243.0DomainFibronectin type-III 15
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712442519_261716634243.0DomainFibronectin type-III 16
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712442625_272316634243.0DomainFibronectin type-III 17
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712442733_284016634243.0DomainFibronectin type-III 18
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712442841_293916634243.0DomainFibronectin type-III 19
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712442949_304216634243.0DomainFibronectin type-III 20
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443062_315316634243.0DomainFibronectin type-III 21
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443168_326016634243.0DomainFibronectin type-III 22
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443264_335516634243.0DomainFibronectin type-III 23
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443357_344616634243.0DomainFibronectin type-III 24
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443451_354416634243.0DomainFibronectin type-III 25
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443553_364716634243.0DomainFibronectin type-III 26
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443657_375416634243.0DomainFibronectin type-III 27
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443758_384716634243.0DomainFibronectin type-III 28
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443848_393416634243.0DomainFibronectin type-III 29
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443935_402516634243.0DomainFibronectin type-III 30
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712444021_423616634243.0DomainFibrinogen C-terminal
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131064_11530674.0DomainFibronectin type-III 2
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131161_12490674.0DomainFibronectin type-III 3
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131263_13520674.0DomainFibronectin type-III 4
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131374_14680674.0DomainFibronectin type-III 5
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131476_15720674.0DomainFibronectin type-III 6
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013156_1680674.0DomainEGF-like 1%3B incomplete
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131574_16690674.0DomainFibronectin type-III 7
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131674_17640674.0DomainFibronectin type-III 8
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131778_18680674.0DomainFibronectin type-III 9
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013183_2130674.0DomainEGF-like 2
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131883_19710674.0DomainFibronectin type-III 10
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131989_20890674.0DomainFibronectin type-III 11
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430132097_21850674.0DomainFibronectin type-III 12
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013214_2440674.0DomainEGF-like 3
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430132196_22960674.0DomainFibronectin type-III 13
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430132305_23980674.0DomainFibronectin type-III 14
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430132408_25020674.0DomainFibronectin type-III 15
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013245_2750674.0DomainEGF-like 4
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430132519_26170674.0DomainFibronectin type-III 16
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430132625_27230674.0DomainFibronectin type-III 17
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430132733_28400674.0DomainFibronectin type-III 18
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013276_3060674.0DomainEGF-like 5
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430132841_29390674.0DomainFibronectin type-III 19
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430132949_30420674.0DomainFibronectin type-III 20
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133062_31530674.0DomainFibronectin type-III 21
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013307_3370674.0DomainEGF-like 6
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133168_32600674.0DomainFibronectin type-III 22
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133264_33550674.0DomainFibronectin type-III 23
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133357_34460674.0DomainFibronectin type-III 24
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013338_3680674.0DomainEGF-like 7
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133451_35440674.0DomainFibronectin type-III 25
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133553_36470674.0DomainFibronectin type-III 26
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133657_37540674.0DomainFibronectin type-III 27
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013369_3990674.0DomainEGF-like 8
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133758_38470674.0DomainFibronectin type-III 28
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133848_39340674.0DomainFibronectin type-III 29
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133935_40250674.0DomainFibronectin type-III 30
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013400_4300674.0DomainEGF-like 9
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430134021_42360674.0DomainFibrinogen C-terminal
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013431_4610674.0DomainEGF-like 10
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013462_4920674.0DomainEGF-like 11
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013493_5230674.0DomainEGF-like 12
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013524_5540674.0DomainEGF-like 13
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013555_5850674.0DomainEGF-like 14
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013586_6160674.0DomainEGF-like 15
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013617_6470674.0DomainEGF-like 16
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013648_6790674.0DomainEGF-like 17
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013684_7140674.0DomainEGF-like 18
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013715_7460674.0DomainEGF-like 19
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013959_10510674.0DomainFibronectin type-III 1
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151064_11530674.0DomainFibronectin type-III 2
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151161_12490674.0DomainFibronectin type-III 3
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151263_13520674.0DomainFibronectin type-III 4
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151374_14680674.0DomainFibronectin type-III 5
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151476_15720674.0DomainFibronectin type-III 6
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015156_1680674.0DomainEGF-like 1%3B incomplete
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151574_16690674.0DomainFibronectin type-III 7
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151674_17640674.0DomainFibronectin type-III 8
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151778_18680674.0DomainFibronectin type-III 9
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015183_2130674.0DomainEGF-like 2
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151883_19710674.0DomainFibronectin type-III 10
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151989_20890674.0DomainFibronectin type-III 11
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840152097_21850674.0DomainFibronectin type-III 12
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015214_2440674.0DomainEGF-like 3
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840152196_22960674.0DomainFibronectin type-III 13
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840152305_23980674.0DomainFibronectin type-III 14
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840152408_25020674.0DomainFibronectin type-III 15
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015245_2750674.0DomainEGF-like 4
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840152519_26170674.0DomainFibronectin type-III 16
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840152625_27230674.0DomainFibronectin type-III 17
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840152733_28400674.0DomainFibronectin type-III 18
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015276_3060674.0DomainEGF-like 5
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840152841_29390674.0DomainFibronectin type-III 19
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840152949_30420674.0DomainFibronectin type-III 20
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153062_31530674.0DomainFibronectin type-III 21
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015307_3370674.0DomainEGF-like 6
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153168_32600674.0DomainFibronectin type-III 22
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153264_33550674.0DomainFibronectin type-III 23
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153357_34460674.0DomainFibronectin type-III 24
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015338_3680674.0DomainEGF-like 7
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153451_35440674.0DomainFibronectin type-III 25
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153553_36470674.0DomainFibronectin type-III 26
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153657_37540674.0DomainFibronectin type-III 27
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015369_3990674.0DomainEGF-like 8
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153758_38470674.0DomainFibronectin type-III 28
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153848_39340674.0DomainFibronectin type-III 29
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153935_40250674.0DomainFibronectin type-III 30
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015400_4300674.0DomainEGF-like 9
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840154021_42360674.0DomainFibrinogen C-terminal
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015431_4610674.0DomainEGF-like 10
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015462_4920674.0DomainEGF-like 11
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015493_5230674.0DomainEGF-like 12
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015524_5540674.0DomainEGF-like 13
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015555_5850674.0DomainEGF-like 14
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015586_6160674.0DomainEGF-like 15
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015617_6470674.0DomainEGF-like 16
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015648_6790674.0DomainEGF-like 17
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015684_7140674.0DomainEGF-like 18
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015715_7460674.0DomainEGF-like 19
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015959_10510674.0DomainFibronectin type-III 1
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151064_11530674.0DomainFibronectin type-III 2
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151161_12490674.0DomainFibronectin type-III 3
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151263_13520674.0DomainFibronectin type-III 4
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151374_14680674.0DomainFibronectin type-III 5
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151476_15720674.0DomainFibronectin type-III 6
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015156_1680674.0DomainEGF-like 1%3B incomplete
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151574_16690674.0DomainFibronectin type-III 7
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151674_17640674.0DomainFibronectin type-III 8
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151778_18680674.0DomainFibronectin type-III 9
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015183_2130674.0DomainEGF-like 2
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151883_19710674.0DomainFibronectin type-III 10
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151989_20890674.0DomainFibronectin type-III 11
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390152097_21850674.0DomainFibronectin type-III 12
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015214_2440674.0DomainEGF-like 3
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390152196_22960674.0DomainFibronectin type-III 13
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390152305_23980674.0DomainFibronectin type-III 14
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390152408_25020674.0DomainFibronectin type-III 15
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015245_2750674.0DomainEGF-like 4
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390152519_26170674.0DomainFibronectin type-III 16
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390152625_27230674.0DomainFibronectin type-III 17
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390152733_28400674.0DomainFibronectin type-III 18
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015276_3060674.0DomainEGF-like 5
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390152841_29390674.0DomainFibronectin type-III 19
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390152949_30420674.0DomainFibronectin type-III 20
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153062_31530674.0DomainFibronectin type-III 21
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015307_3370674.0DomainEGF-like 6
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153168_32600674.0DomainFibronectin type-III 22
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153264_33550674.0DomainFibronectin type-III 23
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153357_34460674.0DomainFibronectin type-III 24
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015338_3680674.0DomainEGF-like 7
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153451_35440674.0DomainFibronectin type-III 25
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153553_36470674.0DomainFibronectin type-III 26
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153657_37540674.0DomainFibronectin type-III 27
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015369_3990674.0DomainEGF-like 8
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153758_38470674.0DomainFibronectin type-III 28
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153848_39340674.0DomainFibronectin type-III 29
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153935_40250674.0DomainFibronectin type-III 30
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015400_4300674.0DomainEGF-like 9
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390154021_42360674.0DomainFibrinogen C-terminal
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015431_4610674.0DomainEGF-like 10
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015462_4920674.0DomainEGF-like 11
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015493_5230674.0DomainEGF-like 12
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015524_5540674.0DomainEGF-like 13
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015555_5850674.0DomainEGF-like 14
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015586_6160674.0DomainEGF-like 15
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015617_6470674.0DomainEGF-like 16
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015648_6790674.0DomainEGF-like 17
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015684_7140674.0DomainEGF-like 18
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015715_7460674.0DomainEGF-like 19
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015959_10510674.0DomainFibronectin type-III 1
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441666_166816634243.0MotifCell attachment site
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131666_16680674.0MotifCell attachment site
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151666_16680674.0MotifCell attachment site
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151666_16680674.0MotifCell attachment site

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115969_10195621050.0Compositional biasNote=Gly/Ser-rich
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115813_8395621050.0RepeatNote=Desmoglein repeat 1
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115840_8695621050.0RepeatNote=Desmoglein repeat 2
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115870_8995621050.0RepeatNote=Desmoglein repeat 3
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115900_9275621050.0RepeatNote=Desmoglein repeat 4
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115928_9565621050.0RepeatNote=Desmoglein repeat 5
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115570_10495621050.0Topological domainCytoplasmic
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115549_5695621050.0TransmembraneHelical
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441064_115316634243.0DomainFibronectin type-III 2
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441161_124916634243.0DomainFibronectin type-III 3
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441263_135216634243.0DomainFibronectin type-III 4
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441374_146816634243.0DomainFibronectin type-III 5
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441476_157216634243.0DomainFibronectin type-III 6
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244156_16816634243.0DomainEGF-like 1%3B incomplete
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441574_166916634243.0DomainFibronectin type-III 7
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244183_21316634243.0DomainEGF-like 2
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244214_24416634243.0DomainEGF-like 3
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244245_27516634243.0DomainEGF-like 4
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244276_30616634243.0DomainEGF-like 5
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244307_33716634243.0DomainEGF-like 6
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244338_36816634243.0DomainEGF-like 7
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244369_39916634243.0DomainEGF-like 8
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244400_43016634243.0DomainEGF-like 9
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244431_46116634243.0DomainEGF-like 10
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244462_49216634243.0DomainEGF-like 11
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244493_52316634243.0DomainEGF-like 12
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244524_55416634243.0DomainEGF-like 13
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244555_58516634243.0DomainEGF-like 14
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244586_61616634243.0DomainEGF-like 15
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244617_64716634243.0DomainEGF-like 16
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244648_67916634243.0DomainEGF-like 17
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244684_71416634243.0DomainEGF-like 18
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244715_74616634243.0DomainEGF-like 19
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244959_105116634243.0DomainFibronectin type-III 1


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Fusion Gene Sequence for DSG1-TNXB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24243_24243_1_DSG1-TNXB_DSG1_chr18_28919988_ENST00000257192_TNXB_chr6_32038191_ENST00000375244_length(transcript)=9839nt_BP=1899nt
CCAGCCCAAGTTTTTAGGGTGGGGATCCAGACTGGTTATACGTACCTTCAGTCCTTCTCCCAGAGGAAGGCAGAAACACCTCAAAGCCTG
CATGTAAGAACATCTACTGAGAAATTATTTTAATCAGACACCAGCTGAGTGGGAGAAAGAAAAAGAACAGAGAAGAACAAACAAAACTCC
CTTGGTCTTGGATGTAAGAGAATCCAGCAGAGATGGACTGGAGTTTCTTCAGAGTAGTTGCAATGCTGTTCATTTTTCTGGTGGTGGTAG
AAGTTAACAGTGAATTCCGAATCCAGGTAAGAGATTATAACACTAAAAATGGCACCATCAAATGGCATTCAATCCGAAGGCAGAAACGTG
AATGGATCAAGTTCGCAGCAGCCTGTCGTGAAGGTGAAGACAACTCAAAGAGGAACCCAATCGCCAAAATTCACTCAGATTGTGCTGCAA
ACCAGCAAGTTACATACCGCATCTCTGGAGTAGGAATTGATCAGCCACCATATGGGATCTTTGTCATTAATCAGAAAACTGGTGAAATTA
ATATAACATCCATAGTTGATCGAGAGGTCACTCCTTTCTTCATTATCTACTGCCGAGCTCTGAACTCAATGGGCCAAGATTTAGAGAGGC
CTCTAGAGCTCAGAGTCAGGGTTTTGGATATAAATGACAACCCTCCAGTGTTTTCAATGGCTACATTTGCAGGACAAATAGAAGAAAATT
CTAATGCAAATACACTGGTGATGATACTCAATGCTACTGACGCAGATGAACCGAACAATTTGAACTCAAAAATAGCCTTCAAGATTATAA
GACAAGAACCTTCAGATTCACCAATGTTTATTATCAACAGAAATACTGGAGAAATTCGAACGATGAATAATTTTCTAGACAGAGAGCAAT
ACGGCCAGTATGCTCTTGCTGTAAGAGGCTCTGACCGAGATGGCGGGGCAGATGGCATGTCAGCGGAATGTGAGTGCAACATTAAAATCC
TCGATGTCAATGATAATATCCCTTACATGGAACAGTCTTCATATACCATAGAAATTCAAGAAAATACTCTAAATTCAAATTTGCTCGAGA
TTAGAGTAATTGATTTGGATGAAGAGTTCTCAGCTAACTGGATGGCAGTAATTTTCTTTATCTCTGGAAATGAAGGAAATTGGTTTGAGA
TAGAAATGAATGAAAGAACAAATGTGGGAATTTTAAAGGTTGTTAAGCCCTTAGATTATGAAGCTATGCAGAGTCTGCAACTCAGTATTG
GTGTCAGAAATAAAGCTGAATTTCATCATTCAATTATGTCTCAATATAAACTGAAAGCATCTGCAATTTCTGTGACTGTGTTAAATGTAA
TTGAAGGCCCAGTGTTTCGTCCAGGTTCAAAGACATATGTTGTAACTGGTAATATGGGATCAAATGATAAAGTGGGAGACTTTGTAGCTA
CTGACCTGGACACAGGTAGACCTTCAACGACTGTTAGGTATGTAATGGGAAATAATCCAGCTGACCTGCTAGCTGTTGATTCAAGAACAG
GCAAACTCACTTTGAAAAATAAAGTTACCAAGGAACAGTACAATATGCTCGGAGGAAAATACCAAGGAACGATTCTCTCTATAGATGATA
ATCTTCAAAGAACTTGCACTGGTACAATTAATATTAACATTCAAAGTTTTGGTAATGACGACAGGACTAATACAGAGCCGAACACTAAAA
TTACTACCAATACTGGCAGACAAGAAAGTACTTCTTCCACTAACTATGATACCAGCACAACTTCTACTGACTCTAGCCAAGTATATTCTT
CTGAACCCGGAAACGGAGCCAAAGATTTGTTATCAGACAATGTACATTTTGGTCCTGCTGGCATTGGACTCCTCATCATGGGATTCTTGG
TCTTAGGATTTGCCCGAGGTGACGCCAGCCCAGGGGCCCCACCCCGCCTTGGGGAGCTGTGGGTGACAGACCCCACCCCAGACTCACTGC
GCCTCTCCTGGACGGTTCCTGAGGGCCAGTTCGACTCTTTTGTGGTCCAGTTCAAGGACAAAGACGGGCCCCAGGTGGTGCCCGTGGAGG
GCCATGAGCGCTCTGTCACTGTCACCCCTCTGGATGCCGGCCGCAAGTACAGATTCCTCCTCTATGGCCTCCTGGGCAAGAAGCGCCATG
GCCCTCTCACTGCCGACGGCACCACGGAAGCCCGGAGTGCTATGGATGATACTGGAACAAAGCGTCCCCCAAAACCCCGTCTGGGGGAGG
AGCTGCAGGTGACCACCGTGACCCAGAACTCCGTGGGCCTCTCCTGGACAGTCCCTGAGGGCCAGTTTGACTCCTTTGTGGTCCAGTACA
AAGACAGGGACGGGCAGCCCCAGGTGGTGCCCGTGGAGGGCAGCCTCAGGGAGGTCAGCGTGCCGGGCCTGGACCCTGCCCACAGGTACA
AGCTGCTGCTCTACGGGCTGCACCACGGCAAGCGTGTGGGCCCCATCTCGGCCGTCGCCATTACTGCCGGCAGGGAAGAAACGGAAACTG
AGACCACGGCCCCGACCCCTCCAGCGCCTGAGCCCCACCTCGGGGAGTTGACAGTGGAGGAGGCCACGTCACACACCCTGCATCTCTCCT
GGATGGTGACTGAGGGAGAATTTGACTCCTTCGAAATCCAGTACACAGATAGAGACGGGCAACTCCAAATGGTCCGCATAGGAGGTGACC
GGAATGACATCACCCTCTCTGGCCTGGAATCCGACCACAGATACCTGGTGACCCTGTATGGTTTCAGTGATGGGAAGCATGTAGGTCCTG
TCCATGTCGAGGCCCTGACAGTCCCGGAGGAGGAGAAGCCTTCAGAACCTCCCACCGCAACCCCCGAGCCCCCCATCAAGCCTCGCCTGG
GGGAGCTGACCGTGACAGATGCCACCCCTGACTCCCTCAGCCTGTCCTGGACAGTTCCCGAGGGACAGTTTGACCACTTCCTGGTCCAGT
ACAGGAATGGAGATGGGCAGCCCAAGGCAGTGAGGGTGCCAGGGCACGAGGAAGGGGTCACCATCTCGGGCCTGGAGCCAGACCATAAAT
ACAAGATGAACCTGTACGGCTTCCACGGTGGCCAGCGCATGGGCCCTGTGTCTGTCGTCGGGGTGACAGCTGCAGAGGAAGAGACCCCCA
GCCCCACAGAACCCAGCATGGAGGCCCCGGAGCCCGCTGAGGAGCCGCTCCTGGGGGAGCTAACAGTGACAGGATCCTCCCCTGACTCGC
TGAGCCTCTCCTGGACCGTCCCCCAGGGCCGCTTCGACTCCTTCACCGTGCAGTACAAGGACAGGGACGGGCGGCCCCAGGTGGTGCGTG
TTGGGGGCGAGGAGAGTGAAGTCACCGTGGGGGGCCTGGAGCCTGGGCGCAAGTACAAGATGCACCTGTACGGCCTCCACGAGGGGCGGC
GCGTGGGCCCAGTGTCTGCTGTGGGCGTCACGGCCCCCGAAGAGGAGTCCCCTGATGCTCCTCTTGCAAAGCTGCGCCTAGGGCAGATGA
CAGTGAGAGACATCACCTCCGACTCCCTCAGCCTCTCCTGGACAGTCCCCGAGGGCCAGTTTGACCATTTCTTGGTCCAGTTTAAGAATG
GGGACGGGCAGCCCAAGGCGGTGCGGGTGCCGGGACACGAGGATGGGGTCACCATCTCGGGCCTGGAGCCAGACCACAAGTACAAGATGA
ACCTGTACGGCTTCCACGGTGGCCAGCGCGTGGGCCCCGTGTCTGCTGTTGGTTTAACTGCCCCAGGAAAGGATGAAGAAATGGCCCCAG
CCTCGACAGAACCTCCCACCCCTGAACCCCCCATCAAGCCTCGCCTGGAGGAGCTGACCGTGACAGATGCGACCCCTGACTCCCTCAGCC
TGTCCTGGACGGTTCCCGAGGGACAGTTTGACCACTTCCTGGTCCAGTACAAGAATGGGGATGGGCAGCCCAAGGCAACACGGGTGCCAG
GACATGAGGACAGGGTCACCATCTCCGGCCTGGAGCCAGACAACAAGTACAAGATGAACCTGTACGGCTTCCACGGTGGCCAGCGTGTGG
GCCCCGTGTCTGCCATCGGGGTGACAGCTGCAGAGGAAGAGACCCCCAGCCCCACAGAACCCAGCATGGAGGCCCCGGAGCCCCCTGAGG
AGCCGCTCCTGGGGGAGCTAACAGTGACAGGATCCTCCCCTGACTCGCTGAGCCTCTCCTGGACCGTCCCCCAGGGCCGCTTCGACTCCT
TCACCGTGCAGTACAAGGACAGGGACGGGCGGCCCCAGGTGGTGCGTGTTGGGGGCGAGGAGAGCGAGGTCACCGTGGGGGGCCTGGAGC
CTGGGCGCAAATACAAGATGCACCTGTATGGCCTCCACGAGGGGCGGCGCGTGGGCCCGGTGTCCACCGTGGGCGTGACTGCCCCACAAG
AGGATGTGGACGAGACCCCCAGCCCTACAGAACCAGGCACAGAGGCCCCAGGGCCCCCCGAGGAGCCTCTCCTGGGGGAGCTGACAGTGA
CAGGATCCTCCCCTGACTCGCTGAGCCTTTCCTGGACCGTCCCCCAGGGCCGCTTTGACTCCTTCACCGTGCAGTACAAGGACAGGGACG
GGCGGCCCCAGGCGGTGCGTGTTGGGGGCCAGGAGAGCAAGGTCACTGTGAGGGGCCTGGAGCCTGGGCGCAAGTACAAGATGCACCTGT
ACGGCCTCCACGAGGGGCGGCGCCTGGGCCCGGTGTCTGCCGTGGGCGTCACAGAGGATGAAGCCGAGACCACCCAAGCAGTGCCTACCA
TGACCCCTGAGCCCCCCATCAAGCCTCGCCTGGGGGAGCTGACCATGACAGATGCCACCCCTGACTCCCTCAGCCTGTCCTGGACGGTTC
CCGAGGGCCAGTTTGACCACTTCCTGGTCCAGTACAGGAATGGGGATGGGCAGCCCAAGGCGGTGCGGGTGCCGGGGCACGAGGACGGGG
TCACCATCTCAGGCCTGGAGCCAGACCATAAATACAAGATGAACCTGTACGGCTTCCACGGTGGCCAGCGCGTGGGCCCCATCTCTGTCA
TTGGGGTGACGGCTGCAGAGGAAGAGACCCCCAGCCCCACGGAACTCAGCACTGAGGCCCCGGAGCCCCCTGAGGAGCCGCTCCTGGGGG
AGCTGACAGTGACAGGATCCTCCCCTGACTCGCTGAGCCTCTCCTGGACCATCCCCCAGGGCCACTTCGACTCCTTCACCGTGCAGTACA
AGGACAGGGACGGGCGGCCCCAGGTGATGCGTGTCAGGGGCGAGGAGAGCGAGGTCACCGTGGGGGGCCTGGAGCCCGGGCGCAAATACA
AGATGCACCTGTACGGCCTCCACGAGGGGCGGCGTGTGGGCCCGGTGTCCACCGTGGGTGTGACAGCTCCAGAGGATGAAGCAGAGACCA
CCCAAGCAGTGCCCACCACAACCCCTGAGCCCCCCAACAAGCCTCGCCTCGGGGAGCTGACCGTGACAGATGCCACCCCTGACTCCCTCA
GCCTGTCCTGGATGGTCCCCGAGGGCCAGTTTGACCACTTCCTGGTCCAGTACAGGAATGGGGATGGGCAGCCCAAGGTGGTGCGGGTGC
CGGGGCACGAGGACGGGGTCACCATCTCAGGCCTGGAGCCAGACCACAAGTACAAGATGAACCTGTACGGCTTCCACGGTGGCCAGCGCG
TGGGCCCCATCTCTGTCATTGGGGTGACAGCTGCAGAGGAAGAAACTCCCGCCCCCACAGAACCCAGCACGGAGGCCCCGGAGCCCCCTG
AGGAGCCGCTCCTGGGGGAGCTGACAGTGACAGGATCCTCCCCTGACTCGCTGAGCCTCTCCTGGACCATCCCCCAGGGCCGCTTCGACT
CCTTCACTGTGCAGTACAAGGACAGGGACGGGCGGCCCCAGGTGGTGCGTGTCAGGGGCGAGGAGAGCGAGGTCACCGTGGGGGGCCTGG
AGCCCGGGTGCAAATACAAGATGCACCTGTACGGCCTCCACGAGGGGCAGCGCGTGGGCCCAGTGTCCGCTGTGGGTGTGACAGCTCCAA
AGGATGAAGCCGAGACCACCCAAGCAGTGCCTACCATGACCCCTGAGCCCCCCATCAAGCCTCGCCTGGGGGAGCTGACCGTGACAGATG
CCACCCCCGACTCCCTCAGCCTGTCCTGGATGGTTCCCGAGGGCCAGTTTGACCACTTCCTGGTCCAGTACAGGAATGGGGATGGGCAGC
CCAAGGCGGTGCGGGTGCCGGGGCACGAGGACGGGGTCACCATCTCAGGCCTGGAGCCAGACCATAAATACAAGATGAACCTGTACGGCT
TCCACGGTGGCCAGCGCGTAGGCCCTGTGTCTGCCATTGGGGTGACGGAGGAAGAGACCCCCAGCCCCACAGAACCCAGCACTGAGGCCC
CGGAGGCCCCTGAGGAGCCGCTCCTGGGGGAGTTGACAGTGACAGGATCCTCCCCTGACTCGCTGAGCCTCTCCTGGACCGTCCCCCAGG
GCCGCTTCGACTCCTTCACCGTGCAGTACAAGGACAGGGACGGGCAGCCCCAGGTGGTGCGTGTCAGGGGCGAGGAGAGCGAGGTCACCG
TGGGGGGCCTGGAGCCCGGGCGCAAATACAAGATGCATCTGTACGGCCTCCACGAGGGGCAGCGCGTGGGCCCAGTGTCCACCGTGGGCA
TCACGGCGCCCCTGCCCACACCACTGCCGGTGGAGCCCCGCCTGGGGGAGCTGGCGGTGGCGGCCGTGACCTCGGACTCAGTGGGCCTCT
CATGGACGGTGGCCCAGGGCCCCTTTGACTCCTTCCTGGTACAGTACAGGGACGCGCAGGGGCAGCCCCAGGCAGTGCCTGTGAGCGGAG
ACCTCCGAGCGGTCGCCGTCTCGGGGCTGGACCCGGCCCGCAAGTACAAGTTCCTGCTCTTTGGACTCCAGAATGGGAAACGCCACGGCC
CAGTCCCTGTGGAGGCCAGGACCGCCCCAGACACCAAACCGTCTCCCCGCCTGGGGGAGCTGACTGTGACAGATGCGACCCCTGACTCCG
TGGGCCTCTCGTGGACGGTCCCTGAGGGCGAATTCGACTCCTTCGTGGTCCAGTACAAGGATAAGGATGGTCGGCTCCAGGTGGTGCCGG
TGGCAGCCAACCAGCGGGAGGTCACAGTCCAGGGCCTGGAGCCCAGTAGGAAATACAGGTTCCTGCTCTATGGTCTGTCAGGCAGGAAAC
GACTGGGCCCCATCTCTGCTGACAGCACCACAGCTCCCCTGGAGAAGGAGCTACCTCCCCACCTGGGGGAACTGACCGTGGCTGAGGAGA
CCTCCAGCTCTCTGCGCCTGTCCTGGACGGTAGCCCAGGGCCCCTTTGACTCCTTCGTGGTCCAGTACAGGGACACGGACGGGCAGCCCA
GGGCAGTGCCTGTGGCCGCAGACCAGCGCACAGTCACCGTAGAGGACCTGGAGCCTGGCAAGAAATACAAGTTTCTGCTCTACGGGCTCC
TTGGGGGAAAGCGCCTGGGCCCGGTCTCTGCCCTGGGAATGACAGCCCCAGAAGAGGACACACCAGCCCCAGAGTTAGCCCCAGAGGCCC
CTGAGCCTCCTGAAGAGCCCCGCCTAGGAGTGCTGACCGTGACCGACACAACCCCAGACTCCATGCGCCTCTCGTGGAGCGTGGCCCAGG
GCCCCTTTGATTCCTTCGTGGTCCAGTATGAGGACACGAACGGGCAGCCCCAGGCCTTGCTCGTGGACGGCGACCAGAGCAAGATCCTCA
TCTCAGGCCTGGAGCCCAGCACCCCCTACAGGTTCCTCCTCTATGGCCTCCATGAAGGGAAGCGCCTGGGGCCCCTCTCAGCTGAGGGCA
CCACAGGGCTGGCTCCTGCTGGTCAGACCTCAGAGGAGTCAAGGCCCCGCCTGTCCCAGCTGTCTGTGACTGACGTGACCACCAGTTCAC
TGAGGCTCAACTGGGAGGCCCCACCGGGGGCCTTCGACTCCTTCCTGCTCCGCTTTGGGGTTCCATCACCAAGCACTCTGGAGCCGCATC
CGCGTCCACTGCTGCAGCGCGAGCTGATGGTGCCGGGGACGCGGCACTCGGCCGTGCTCCGGGACCTGCGTTCCGGGACTCTGTACAGCC
TGACACTGTATGGGCTGCGAGGACCCCACAAGGCCGACAGCATCCAGGGAACCGCCCGCACCCTCAGCCCAGTTCTGGAGAGCCCCCGTG
ACCTCCAATTCAGTGAAATCAGGGAGACCTCAGCCAAGGTCAACTGGATGCCCCCACCATCCCGGGCGGACAGCTTCAAAGTCTCCTACC
AGCTGGCGGACGGAGGGGAGCCTCAGAGTGTGCAGGTGGATGGCCAGGCCCGGACCCAGAAACTCCAGGGGCTGATCCCAGGCGCTCGCT
ATGAGGTGACCGTGGTCTCGGTCCGAGGCTTTGAGGAGAGTGAGCCTCTCACAGGCTTCCTCACCACGGTTCCTGACGGTCCCACACAGT
TGCGTGCACTGAACTTGACCGAGGGATTCGCCGTGCTGCACTGGAAGCCCCCCCAGAATCCTGTGGACACCTATGACGTCCAGGTCACAG
CCCCTGGGGCCCCGCCTCTGCAGGCGGAGACCCCAGGCAGCGCGGTGGACTACCCCCTGCATGACCTTGTCCTCCACACCAACTACACCG
CCACAGTGCGTGGCCTGCGGGGCCCCAACCTCACTTCCCCAGCCAGCATCACCTTCACCACAGGGCTAGAGGCCCCTCGGGACTTGGAGG
CCAAGGAAGTGACCCCCCGCACCGCCCTGCTCACTTGGACTGAGCCCCCAGTCCGGCCCGCAGGCTACCTGCTCAGCTTCCACACCCCTG
GTGGACAGAACCAGGAGATCCTGCTCCCAGGAGGGATCACATCTCACCAGCTCCTTGGCCTCTTTCCCTCCACCTCCTACAATGCACGGC
TCCAGGCCATGTGGGGCCAGAGCCTCCTGCCGCCCGTGTCCACCTCTTTCACCACGGGTGGGCTGCGGATCCCCTTCCCCAGGGACTGCG
GGGAGGAGATGCAGAACGGAGCCGGTGCCTCCAGGACCAGCACCATCTTCCTCAACGGCAACCGCGAGCGGCCCCTGAACGTGTTTTGCG
ACATGGAGACTGATGGGGGCGGCTGGCTGGTGTTCCAGCGCCGCATGGATGGACAGACAGACTTCTGGAGGGACTGGGAGGACTATGCCC
ATGGTTTTGGGAACATCTCTGGAGAGTTCTGGCTGGGCAATGAGGCCCTGCACAGCCTGACACAGGCAGGTGACTACTCCATGCGCGTGG
ACCTGCGGGCTGGGGACGAGGCTGTGTTCGCCCAGTACGACTCCTTCCACGTAGACTCGGCTGCGGAGTACTACCGCCTCCACTTGGAGG
GCTACCACGGCACCGCAGGGGACTCCATGAGCTACCACAGCGGCAGTGTCTTCTCTGCCCGTGATCGGGACCCCAACAGCTTGCTCATCT
CCTGCGCTGTCTCCTACCGAGGGGCCTGGTGGTACAGGAACTGCCACTACGCCAACCTCAACGGGCTCTACGGGAGCACAGTGGACCATC
AGGGAGTGAGCTGGTACCACTGGAAGGGCTTCGAGTTCTCGGTGCCCTTCACGGAAATGAAGCTGAGACCAAGAAACTTTCGCTCCCCAG
CGGGGGGAGGCTGAGCTGCTGCCCACCTCTCTCGCACCCCAGTATGACTGCCGAGCACTGAGGGGTCGCCCCGAGAGAAGAGCCAGGGTC
CTTCACCACCCAGCCGCTGGAGGAAGCCTTCTCTGCCAGCGATCTCGCAGCACTGTGTTTACAGGGGGGAGGGGAGGGGTTCGTACGGGA

>24243_24243_1_DSG1-TNXB_DSG1_chr18_28919988_ENST00000257192_TNXB_chr6_32038191_ENST00000375244_length(amino acids)=3143AA_BP=1202
MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGV
GIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILN
ATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYME
QSSYTIEIQENTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHS
IMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTK
EQYNMLGGKYQGTILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLL
SDNVHFGPAGIGLLIMGFLVLGFARGDASPGAPPRLGELWVTDPTPDSLRLSWTVPEGQFDSFVVQFKDKDGPQVVPVEGHERSVTVTPL
DAGRKYRFLLYGLLGKKRHGPLTADGTTEARSAMDDTGTKRPPKPRLGEELQVTTVTQNSVGLSWTVPEGQFDSFVVQYKDRDGQPQVVP
VEGSLREVSVPGLDPAHRYKLLLYGLHHGKRVGPISAVAITAGREETETETTAPTPPAPEPHLGELTVEEATSHTLHLSWMVTEGEFDSF
EIQYTDRDGQLQMVRIGGDRNDITLSGLESDHRYLVTLYGFSDGKHVGPVHVEALTVPEEEKPSEPPTATPEPPIKPRLGELTVTDATPD
SLSLSWTVPEGQFDHFLVQYRNGDGQPKAVRVPGHEEGVTISGLEPDHKYKMNLYGFHGGQRMGPVSVVGVTAAEEETPSPTEPSMEAPE
PAEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSAVGVT
APEEESPDAPLAKLRLGQMTVRDITSDSLSLSWTVPEGQFDHFLVQFKNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRV
GPVSAVGLTAPGKDEEMAPASTEPPTPEPPIKPRLEELTVTDATPDSLSLSWTVPEGQFDHFLVQYKNGDGQPKATRVPGHEDRVTISGL
EPDNKYKMNLYGFHGGQRVGPVSAIGVTAAEEETPSPTEPSMEAPEPPEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGR
PQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSTVGVTAPQEDVDETPSPTEPGTEAPGPPEEPLLGELTVTGSSPDSLSLS
WTVPQGRFDSFTVQYKDRDGRPQAVRVGGQESKVTVRGLEPGRKYKMHLYGLHEGRRLGPVSAVGVTEDEAETTQAVPTMTPEPPIKPRL
GELTMTDATPDSLSLSWTVPEGQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPISVIGVTAAEEETP
SPTELSTEAPEPPEEPLLGELTVTGSSPDSLSLSWTIPQGHFDSFTVQYKDRDGRPQVMRVRGEESEVTVGGLEPGRKYKMHLYGLHEGR
RVGPVSTVGVTAPEDEAETTQAVPTTTPEPPNKPRLGELTVTDATPDSLSLSWMVPEGQFDHFLVQYRNGDGQPKVVRVPGHEDGVTISG
LEPDHKYKMNLYGFHGGQRVGPISVIGVTAAEEETPAPTEPSTEAPEPPEEPLLGELTVTGSSPDSLSLSWTIPQGRFDSFTVQYKDRDG
RPQVVRVRGEESEVTVGGLEPGCKYKMHLYGLHEGQRVGPVSAVGVTAPKDEAETTQAVPTMTPEPPIKPRLGELTVTDATPDSLSLSWM
VPEGQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPVSAIGVTEEETPSPTEPSTEAPEAPEEPLLGE
LTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGQPQVVRVRGEESEVTVGGLEPGRKYKMHLYGLHEGQRVGPVSTVGITAPLPTPLPV
EPRLGELAVAAVTSDSVGLSWTVAQGPFDSFLVQYRDAQGQPQAVPVSGDLRAVAVSGLDPARKYKFLLFGLQNGKRHGPVPVEARTAPD
TKPSPRLGELTVTDATPDSVGLSWTVPEGEFDSFVVQYKDKDGRLQVVPVAANQREVTVQGLEPSRKYRFLLYGLSGRKRLGPISADSTT
APLEKELPPHLGELTVAEETSSSLRLSWTVAQGPFDSFVVQYRDTDGQPRAVPVAADQRTVTVEDLEPGKKYKFLLYGLLGGKRLGPVSA
LGMTAPEEDTPAPELAPEAPEPPEEPRLGVLTVTDTTPDSMRLSWSVAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPYR
FLLYGLHEGKRLGPLSAEGTTGLAPAGQTSEESRPRLSQLSVTDVTTSSLRLNWEAPPGAFDSFLLRFGVPSPSTLEPHPRPLLQRELMV
PGTRHSAVLRDLRSGTLYSLTLYGLRGPHKADSIQGTARTLSPVLESPRDLQFSEIRETSAKVNWMPPPSRADSFKVSYQLADGGEPQSV
QVDGQARTQKLQGLIPGARYEVTVVSVRGFEESEPLTGFLTTVPDGPTQLRALNLTEGFAVLHWKPPQNPVDTYDVQVTAPGAPPLQAET
PGSAVDYPLHDLVLHTNYTATVRGLRGPNLTSPASITFTTGLEAPRDLEAKEVTPRTALLTWTEPPVRPAGYLLSFHTPGGQNQEILLPG
GITSHQLLGLFPSTSYNARLQAMWGQSLLPPVSTSFTTGGLRIPFPRDCGEEMQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLV
FQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSMRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMS

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Fusion Gene PPI Analysis for DSG1-TNXB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DSG1-TNXB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DSG1-TNXB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDSG1C3809719Severe dermatitis, multiple allergies, metabolic wasting syndrome2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneDSG1C4707237Striate palmoplantar keratoderma2ORPHANET
HgeneDSG1C0011603Dermatitis1CTD_human
HgeneDSG1C0020517Hypersensitivity1CTD_human
HgeneDSG1C0025517Metabolic Diseases1CTD_human
HgeneDSG1C1527304Allergic Reaction1CTD_human
HgeneDSG1C2931122Keratosis palmoplantaris striata 11CTD_human;GENOMICS_ENGLAND
HgeneDSG1C4755302Focal palmoplantar keratoderma with joint keratoses1ORPHANET
HgeneDSG1C4755309Diffuse palmoplantar keratoderma with painful fissures1ORPHANET
TgeneC1848029Ehlers-Danlos syndrome caused by tenascin-X deficiency4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0036341Schizophrenia3PSYGENET
TgeneC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneC4014831VESICOURETERAL REFLUX 81GENOMICS_ENGLAND;UNIPROT
TgeneC4706552Familial vesicoureteral reflux1ORPHANET