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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:E2F5-NDRG1 (FusionGDB2 ID:HG1875TG10397)

Fusion Gene Summary for E2F5-NDRG1

check button Fusion gene summary
Fusion gene informationFusion gene name: E2F5-NDRG1
Fusion gene ID: hg1875tg10397
HgeneTgene
Gene symbol

E2F5

NDRG1

Gene ID

1875

10397

Gene nameE2F transcription factor 5N-myc downstream regulated 1
SynonymsE2F-5CAP43|CMT4D|DRG-1|DRG1|GC4|HMSNL|NDR1|NMSL|PROXY1|RIT42|RTP|TARG1|TDD5
Cytomap('E2F5')('NDRG1')

8q21.2

8q24.22

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor E2F5E2F transcription factor 5, p130-bindingprotein NDRG1N-myc downstream-regulated gene 1 proteindifferentiation-related gene 1 proteinnickel-specific induction protein Cap43protein regulated by oxygen-1reducing agents and tunicamycin-responsive protein
Modification date2020031320200328
UniProtAcc

Q15329

Q92597

Ensembl transtripts involved in fusion geneENST00000519128, ENST00000256117, 
ENST00000416274, ENST00000418930, 
ENST00000517476, ENST00000521429, 
Fusion gene scores* DoF score5 X 5 X 4=10024 X 17 X 10=4080
# samples 726
** MAII scorelog2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/4080*10)=-3.9719856238304
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: E2F5 [Title/Abstract] AND NDRG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointE2F5(86089889)-NDRG1(134276895), # samples:1
Anticipated loss of major functional domain due to fusion event.E2F5-NDRG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
E2F5-NDRG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
E2F5-NDRG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
E2F5-NDRG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across E2F5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NDRG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-2396E2F5chr8

86089889

+NDRG1chr8

134276895

-


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Fusion Gene ORF analysis for E2F5-NDRG1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000519128ENST00000323851E2F5chr8

86089889

+NDRG1chr8

134276895

-
3UTR-3CDSENST00000519128ENST00000354944E2F5chr8

86089889

+NDRG1chr8

134276895

-
3UTR-5UTRENST00000519128ENST00000522476E2F5chr8

86089889

+NDRG1chr8

134276895

-
3UTR-intronENST00000519128ENST00000414097E2F5chr8

86089889

+NDRG1chr8

134276895

-
3UTR-intronENST00000519128ENST00000518066E2F5chr8

86089889

+NDRG1chr8

134276895

-
3UTR-intronENST00000519128ENST00000518176E2F5chr8

86089889

+NDRG1chr8

134276895

-
3UTR-intronENST00000519128ENST00000521414E2F5chr8

86089889

+NDRG1chr8

134276895

-
3UTR-intronENST00000519128ENST00000537882E2F5chr8

86089889

+NDRG1chr8

134276895

-
5CDS-5UTRENST00000256117ENST00000522476E2F5chr8

86089889

+NDRG1chr8

134276895

-
5CDS-5UTRENST00000416274ENST00000522476E2F5chr8

86089889

+NDRG1chr8

134276895

-
5CDS-5UTRENST00000418930ENST00000522476E2F5chr8

86089889

+NDRG1chr8

134276895

-
5CDS-intronENST00000256117ENST00000414097E2F5chr8

86089889

+NDRG1chr8

134276895

-
5CDS-intronENST00000256117ENST00000518066E2F5chr8

86089889

+NDRG1chr8

134276895

-
5CDS-intronENST00000256117ENST00000518176E2F5chr8

86089889

+NDRG1chr8

134276895

-
5CDS-intronENST00000256117ENST00000521414E2F5chr8

86089889

+NDRG1chr8

134276895

-
5CDS-intronENST00000256117ENST00000537882E2F5chr8

86089889

+NDRG1chr8

134276895

-
5CDS-intronENST00000416274ENST00000414097E2F5chr8

86089889

+NDRG1chr8

134276895

-
5CDS-intronENST00000416274ENST00000518066E2F5chr8

86089889

+NDRG1chr8

134276895

-
5CDS-intronENST00000416274ENST00000518176E2F5chr8

86089889

+NDRG1chr8

134276895

-
5CDS-intronENST00000416274ENST00000521414E2F5chr8

86089889

+NDRG1chr8

134276895

-
5CDS-intronENST00000416274ENST00000537882E2F5chr8

86089889

+NDRG1chr8

134276895

-
5CDS-intronENST00000418930ENST00000414097E2F5chr8

86089889

+NDRG1chr8

134276895

-
5CDS-intronENST00000418930ENST00000518066E2F5chr8

86089889

+NDRG1chr8

134276895

-
5CDS-intronENST00000418930ENST00000518176E2F5chr8

86089889

+NDRG1chr8

134276895

-
5CDS-intronENST00000418930ENST00000521414E2F5chr8

86089889

+NDRG1chr8

134276895

-
5CDS-intronENST00000418930ENST00000537882E2F5chr8

86089889

+NDRG1chr8

134276895

-
In-frameENST00000256117ENST00000323851E2F5chr8

86089889

+NDRG1chr8

134276895

-
In-frameENST00000256117ENST00000354944E2F5chr8

86089889

+NDRG1chr8

134276895

-
In-frameENST00000416274ENST00000323851E2F5chr8

86089889

+NDRG1chr8

134276895

-
In-frameENST00000416274ENST00000354944E2F5chr8

86089889

+NDRG1chr8

134276895

-
In-frameENST00000418930ENST00000323851E2F5chr8

86089889

+NDRG1chr8

134276895

-
In-frameENST00000418930ENST00000354944E2F5chr8

86089889

+NDRG1chr8

134276895

-
intron-3CDSENST00000517476ENST00000323851E2F5chr8

86089889

+NDRG1chr8

134276895

-
intron-3CDSENST00000517476ENST00000354944E2F5chr8

86089889

+NDRG1chr8

134276895

-
intron-3CDSENST00000521429ENST00000323851E2F5chr8

86089889

+NDRG1chr8

134276895

-
intron-3CDSENST00000521429ENST00000354944E2F5chr8

86089889

+NDRG1chr8

134276895

-
intron-5UTRENST00000517476ENST00000522476E2F5chr8

86089889

+NDRG1chr8

134276895

-
intron-5UTRENST00000521429ENST00000522476E2F5chr8

86089889

+NDRG1chr8

134276895

-
intron-intronENST00000517476ENST00000414097E2F5chr8

86089889

+NDRG1chr8

134276895

-
intron-intronENST00000517476ENST00000518066E2F5chr8

86089889

+NDRG1chr8

134276895

-
intron-intronENST00000517476ENST00000518176E2F5chr8

86089889

+NDRG1chr8

134276895

-
intron-intronENST00000517476ENST00000521414E2F5chr8

86089889

+NDRG1chr8

134276895

-
intron-intronENST00000517476ENST00000537882E2F5chr8

86089889

+NDRG1chr8

134276895

-
intron-intronENST00000521429ENST00000414097E2F5chr8

86089889

+NDRG1chr8

134276895

-
intron-intronENST00000521429ENST00000518066E2F5chr8

86089889

+NDRG1chr8

134276895

-
intron-intronENST00000521429ENST00000518176E2F5chr8

86089889

+NDRG1chr8

134276895

-
intron-intronENST00000521429ENST00000521414E2F5chr8

86089889

+NDRG1chr8

134276895

-
intron-intronENST00000521429ENST00000537882E2F5chr8

86089889

+NDRG1chr8

134276895

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000418930E2F5chr886089889+ENST00000323851NDRG1chr8134276895-32234301961515439
ENST00000418930E2F5chr886089889+ENST00000354944NDRG1chr8134276895-30124301961305369
ENST00000256117E2F5chr886089889+ENST00000323851NDRG1chr8134276895-3064271371356439
ENST00000256117E2F5chr886089889+ENST00000354944NDRG1chr8134276895-2853271371146369
ENST00000416274E2F5chr886089889+ENST00000323851NDRG1chr8134276895-3061268341353439
ENST00000416274E2F5chr886089889+ENST00000354944NDRG1chr8134276895-2850268341143369

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000418930ENST00000323851E2F5chr886089889+NDRG1chr8134276895-0.0209669230.97903305
ENST00000418930ENST00000354944E2F5chr886089889+NDRG1chr8134276895-0.0238359590.97616404
ENST00000256117ENST00000323851E2F5chr886089889+NDRG1chr8134276895-0.0191719050.9808281
ENST00000256117ENST00000354944E2F5chr886089889+NDRG1chr8134276895-0.0207071360.97929287
ENST00000416274ENST00000323851E2F5chr886089889+NDRG1chr8134276895-0.0191071560.9808928
ENST00000416274ENST00000354944E2F5chr886089889+NDRG1chr8134276895-0.0204715360.9795284

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Fusion Genomic Features for E2F5-NDRG1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for E2F5-NDRG1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:86089889/chr8:134276895)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
E2F5

Q15329

NDRG1

Q92597

FUNCTION: Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14}.FUNCTION: Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. {ECO:0000269|PubMed:15247272, ECO:0000269|PubMed:15377670, ECO:0000269|PubMed:17786215, ECO:0000269|PubMed:9766676}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneE2F5chr8:86089889chr8:134276895ENST00000416274+1833_3978347.0Compositional biasNote=Poly-Pro
HgeneE2F5chr8:86089889chr8:134276895ENST00000418930+1833_3978346.0Compositional biasNote=Poly-Pro
TgeneNDRG1chr8:86089889chr8:134276895ENST00000323851216339_36833395.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
TgeneNDRG1chr8:86089889chr8:134276895ENST00000414097216339_36833395.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
TgeneNDRG1chr8:86089889chr8:134276895ENST00000522476014339_3680329.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
TgeneNDRG1chr8:86089889chr8:134276895ENST00000537882015339_3680314.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
TgeneNDRG1chr8:86089889chr8:134276895ENST00000323851216339_34833395.0RepeatNote=1
TgeneNDRG1chr8:86089889chr8:134276895ENST00000323851216349_35833395.0RepeatNote=2
TgeneNDRG1chr8:86089889chr8:134276895ENST00000323851216359_36833395.0RepeatNote=3
TgeneNDRG1chr8:86089889chr8:134276895ENST00000414097216339_34833395.0RepeatNote=1
TgeneNDRG1chr8:86089889chr8:134276895ENST00000414097216349_35833395.0RepeatNote=2
TgeneNDRG1chr8:86089889chr8:134276895ENST00000414097216359_36833395.0RepeatNote=3
TgeneNDRG1chr8:86089889chr8:134276895ENST00000522476014339_3480329.0RepeatNote=1
TgeneNDRG1chr8:86089889chr8:134276895ENST00000522476014349_3580329.0RepeatNote=2
TgeneNDRG1chr8:86089889chr8:134276895ENST00000522476014359_3680329.0RepeatNote=3
TgeneNDRG1chr8:86089889chr8:134276895ENST00000537882015339_3480314.0RepeatNote=1
TgeneNDRG1chr8:86089889chr8:134276895ENST00000537882015349_3580314.0RepeatNote=2
TgeneNDRG1chr8:86089889chr8:134276895ENST00000537882015359_3680314.0RepeatNote=3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneE2F5chr8:86089889chr8:134276895ENST00000416274+18233_23678347.0Compositional biasNote=Poly-Ser
HgeneE2F5chr8:86089889chr8:134276895ENST00000418930+18233_23678346.0Compositional biasNote=Poly-Ser
HgeneE2F5chr8:86089889chr8:134276895ENST00000517476+18233_2360186.0Compositional biasNote=Poly-Ser
HgeneE2F5chr8:86089889chr8:134276895ENST00000517476+1833_390186.0Compositional biasNote=Poly-Pro
HgeneE2F5chr8:86089889chr8:134276895ENST00000416274+1847_11878347.0DNA bindingOntology_term=ECO:0000255
HgeneE2F5chr8:86089889chr8:134276895ENST00000418930+1847_11878346.0DNA bindingOntology_term=ECO:0000255
HgeneE2F5chr8:86089889chr8:134276895ENST00000517476+1847_1180186.0DNA bindingOntology_term=ECO:0000255
HgeneE2F5chr8:86089889chr8:134276895ENST00000416274+1881_11878347.0MotifNote=DEF box
HgeneE2F5chr8:86089889chr8:134276895ENST00000418930+1881_11878346.0MotifNote=DEF box
HgeneE2F5chr8:86089889chr8:134276895ENST00000517476+1881_1180186.0MotifNote=DEF box
HgeneE2F5chr8:86089889chr8:134276895ENST00000416274+18119_21578347.0RegionDimerization
HgeneE2F5chr8:86089889chr8:134276895ENST00000416274+18287_34678347.0RegionTransactivation
HgeneE2F5chr8:86089889chr8:134276895ENST00000416274+18323_34078347.0RegionRBL2 association
HgeneE2F5chr8:86089889chr8:134276895ENST00000416274+1876_9878347.0RegionNote=Leucine-zipper
HgeneE2F5chr8:86089889chr8:134276895ENST00000418930+18119_21578346.0RegionDimerization
HgeneE2F5chr8:86089889chr8:134276895ENST00000418930+18287_34678346.0RegionTransactivation
HgeneE2F5chr8:86089889chr8:134276895ENST00000418930+18323_34078346.0RegionRBL2 association
HgeneE2F5chr8:86089889chr8:134276895ENST00000418930+1876_9878346.0RegionNote=Leucine-zipper
HgeneE2F5chr8:86089889chr8:134276895ENST00000517476+18119_2150186.0RegionDimerization
HgeneE2F5chr8:86089889chr8:134276895ENST00000517476+18287_3460186.0RegionTransactivation
HgeneE2F5chr8:86089889chr8:134276895ENST00000517476+18323_3400186.0RegionRBL2 association
HgeneE2F5chr8:86089889chr8:134276895ENST00000517476+1876_980186.0RegionNote=Leucine-zipper


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Fusion Gene Sequence for E2F5-NDRG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24789_24789_1_E2F5-NDRG1_E2F5_chr8_86089889_ENST00000256117_NDRG1_chr8_134276895_ENST00000323851_length(transcript)=3064nt_BP=271nt
GTGCGCGGGGGCCCGACCACCGCGGGGCCGGGACGCGATGGCGGCGGCAGAGCCCGCGAGCTCGGGCCAGCAGGCGCCGGCAGGGCAGGG
GCAGGGCCAGCGGCCGCCGCCGCAGCCTCCGCAGGCGCAAGCCCCGCAGCCGCCCCCGCCGCCGCAGCTCGGGGGCGCCGGGGGCGGCAG
CAGCAGGCACGAGAAGAGCCTGGGGCTGCTCACTACCAAGTTCGTGTCGCTGCTGCAGGAGGCCAAGGACGGCGTTCTGGATCTCAAAGC
GGAGCAGGACATCGAGACTTTACATGGCTCTGTTCACGTCACGCTGTGTGGGACTCCCAAGGGAAACCGGCCTGTCATCCTCACCTACCA
TGACATCGGCATGAACCACAAAACCTGCTACAACCCCCTCTTCAACTACGAGGACATGCAGGAGATCACCCAGCACTTTGCCGTCTGCCA
CGTGGACGCCCCTGGCCAGCAGGACGGCGCAGCCTCCTTCCCCGCAGGGTACATGTACCCCTCCATGGATCAGCTGGCTGAAATGCTTCC
TGGAGTCCTTCAACAGTTTGGGCTGAAAAGCATTATTGGCATGGGAACAGGAGCAGGCGCCTACATCCTAACTCGATTTGCTCTAAACAA
CCCTGAGATGGTGGAGGGCCTTGTCCTTATCAACGTGAACCCTTGTGCGGAAGGCTGGATGGACTGGGCCGCCTCCAAGATCTCAGGATG
GACCCAAGCTCTGCCGGACATGGTGGTGTCCCACCTTTTTGGGAAGGAAGAAATGCAGAGTAACGTGGAAGTGGTCCACACCTACCGCCA
GCACATTGTGAATGACATGAACCCCGGCAACCTGCACCTGTTCATCAATGCCTACAACAGCCGGCGCGACCTGGAGATTGAGCGACCAAT
GCCGGGAACCCACACAGTCACCCTGCAGTGCCCTGCTCTGTTGGTGGTTGGGGACAGCTCGCCTGCAGTGGATGCCGTGGTGGAGTGCAA
CTCAAAATTGGACCCAACAAAGACCACTCTCCTCAAGATGGCGGACTGTGGCGGCCTCCCGCAGATCTCCCAGCCGGCCAAGCTCGCTGA
GGCCTTCAAGTACTTCGTGCAGGGCATGGGATACATGCCCTCGGCTAGCATGACCCGCCTGATGCGGTCCCGCACAGCCTCTGGTTCCAG
CGTCACTTCTCTGGATGGCACCCGCAGCCGCTCCCACACCAGCGAGGGCACCCGAAGCCGCTCCCACACCAGCGAGGGCACCCGCAGCCG
CTCGCACACCAGCGAGGGGGCCCACCTGGACATCACCCCCAACTCGGGTGCTGCTGGGAACAGCGCCGGGCCCAAGTCCATGGAGGTCTC
CTGCTAGGCGGCCTGCCCAGCTGCCGCCCCCGGACTCTGATCTCTGTAGTGGCCCCCTCCTCCCCGGCCCCTTTTCGCCCCCTGCCTGCC
ATACTGCGCCTAACTCGGTATTAATCCAAAGCTTATTTTGTAAGAGTGAGCTCTGGTGGAGACAAATGAGGTCTATTACGTGGGTGCCCT
CTCCAAAGGCGGGGTGGCGGTGGACCAAAGGAAGGAAGCAAGCATCTCCGCATCGCATCCTCTTCCATTAACCAGTGGCCGGTTGCCACT
CTCCTCCCCTCCCTCAGAGACACCAAACTGCCAAAAACAAGACGCGTAGCAGCACACACTTCACAAAGCCAAGCCTAGGCCGCCCTGAGC
ATCCTGGTTCAAACGGGTGCCTGGTCAGAAGGCCAGCCGCCCACTTCCCGTTTCCTCTTTAACTGAGGAGAAGCTGATCCAGTTTCCGGA
AACAAAATCCTTTTCTCATTTGGGGAGGGGGGTAATAGTGACATGCAGGCACCTCTTTTAAACAGGCAAAACAGGAAGGGGGAAAAGGTG
GGATTCATGTCGAGGCTAGAGGCATTTGGAACAACAAATCTACGTAGTTAACTTGAAGAAACCGATTTTTAAAGTTGGTGCATCTAGAAA
GCTTTGAATGCAGAAGCAAACAAGCTTGATTTTTCTAGCATCCTCTTAATGTGCAGCAAAAGCAGGCGACAAAATCTCCTGGCTTTACAG
ACAAAAATATTTCAGCAAACGTTGGGCATCATGGTTTTTGAAGGCTTTAGTTCTGCTTTCTGCCTCTCCTCCACAGCCCCAACCTCCCAC
CCCTGATACATGAGCCAGTGATTATTCTTGTTCAGGGAGAAGATCATTTAGATTTGTTTTGCATTCCTTAGAATGGAGGGCAACATTCCA
CAGCTGCCCTGGCTGTGATGAGTGTCCTTGCAGGGGCCGGAGTAGGAGCACTGGGGTGGGGGTGGAATTGGGGTTACTCGATGTAAGGGA
TTCCTTGTTGTTGTGTTGAGATCCAGTGCAGTTGTGATTTCTGTGGATCCCAGCTTGGTTCCAGGAATTTTGTGTGATTGGCTTAAATCC
AGTTTTCAATCTTCGACAGCTGGGCTGGAACGTGAACTCAGTAGCTGAACCTGTCTGACCCGGTCACGTTCTTGGATCCTCAGAACTCTT
TGCTCTTGTCGGGGTGGGGGTGGGAACTCACGTGGGGAGCGGTGGCTGAGAAAATGTAAGGATTCTGGAATACATATTCCATGGGACTTT
CCTTCCCTCTCCTGCTTCCTCTTTTCCTGCTCCCTAACCTTTCGCCGAATGGGGCAGCACCACTGACGTTTCTGGGCGGCCAGTGCGGCT
GCCAGGTTCCTGTACTACTGCCTTGTACTTTTCATTTTGGCTCACCGTGGATTTTCTCATAGGAAGTTTGGTCAGAGTGAATTGAATATT
GTAAGTCAGCCACTGGGACCCGAGGATTTCTGGGACCCCGCAGTTGGGAGGAGGAAGTAGTCCAGCCTTCCAGGTGGCGTGAGAGGCAAT
GACTCGTTACCTGCCGCCCATCACCTTGGAGGCCTTCCCTGGCCTTGAGTAGAAAAGTCGGGGATCGGGGCAAGAGAGGCTGAGTACGGA
TGGGAAACTATTGTGCACAAGTCTTTCCAGAGGAGTTTCTTAATGAGATATTTGTATTTATTTCCAGACCAATAAATTTGTAACTTTGCA

>24789_24789_1_E2F5-NDRG1_E2F5_chr8_86089889_ENST00000256117_NDRG1_chr8_134276895_ENST00000323851_length(amino acids)=439AA_BP=78
MAAAEPASSGQQAPAGQGQGQRPPPQPPQAQAPQPPPPPQLGGAGGGSSRHEKSLGLLTTKFVSLLQEAKDGVLDLKAEQDIETLHGSVH
VTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYPSMDQLAEMLPGVLQQFGLKSII
GMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLH
LFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYM

--------------------------------------------------------------
>24789_24789_2_E2F5-NDRG1_E2F5_chr8_86089889_ENST00000256117_NDRG1_chr8_134276895_ENST00000354944_length(transcript)=2853nt_BP=271nt
GTGCGCGGGGGCCCGACCACCGCGGGGCCGGGACGCGATGGCGGCGGCAGAGCCCGCGAGCTCGGGCCAGCAGGCGCCGGCAGGGCAGGG
GCAGGGCCAGCGGCCGCCGCCGCAGCCTCCGCAGGCGCAAGCCCCGCAGCCGCCCCCGCCGCCGCAGCTCGGGGGCGCCGGGGGCGGCAG
CAGCAGGCACGAGAAGAGCCTGGGGCTGCTCACTACCAAGTTCGTGTCGCTGCTGCAGGAGGCCAAGGACGGCGTTCTGGATCTCAAAGC
GGAGCAGGACATCGAGACTTTACATGGCTCTGTTCACGTCACGCTGTGTGGGACTCCCAAGGGAAACCGGCCTGTCATCCTCACCTACCA
TGACATCGGCATGAACCACAAAACCTGCGCCTACATCCTAACTCGATTTGCTCTAAACAACCCTGAGATGGTGGAGGGCCTTGTCCTTAT
CAACGTGAACCCTTGTGCGGAAGGCTGGATGGACTGGGCCGCCTCCAAGATCTCAGGATGGACCCAAGCTCTGCCGGACATGGTGGTGTC
CCACCTTTTTGGGAAGGAAGAAATGCAGAGTAACGTGGAAGTGGTCCACACCTACCGCCAGCACATTGTGAATGACATGAACCCCGGCAA
CCTGCACCTGTTCATCAATGCCTACAACAGCCGGCGCGACCTGGAGATTGAGCGACCAATGCCGGGAACCCACACAGTCACCCTGCAGTG
CCCTGCTCTGTTGGTGGTTGGGGACAGCTCGCCTGCAGTGGATGCCGTGGTGGAGTGCAACTCAAAATTGGACCCAACAAAGACCACTCT
CCTCAAGATGGCGGACTGTGGCGGCCTCCCGCAGATCTCCCAGCCGGCCAAGCTCGCTGAGGCCTTCAAGTACTTCGTGCAGGGCATGGG
ATACATGCCCTCGGCTAGCATGACCCGCCTGATGCGGTCCCGCACAGCCTCTGGTTCCAGCGTCACTTCTCTGGATGGCACCCGCAGCCG
CTCCCACACCAGCGAGGGCACCCGAAGCCGCTCCCACACCAGCGAGGGCACCCGCAGCCGCTCGCACACCAGCGAGGGGGCCCACCTGGA
CATCACCCCCAACTCGGGTGCTGCTGGGAACAGCGCCGGGCCCAAGTCCATGGAGGTCTCCTGCTAGGCGGCCTGCCCAGCTGCCGCCCC
CGGACTCTGATCTCTGTAGTGGCCCCCTCCTCCCCGGCCCCTTTTCGCCCCCTGCCTGCCATACTGCGCCTAACTCGGTATTAATCCAAA
GCTTATTTTGTAAGAGTGAGCTCTGGTGGAGACAAATGAGGTCTATTACGTGGGTGCCCTCTCCAAAGGCGGGGTGGCGGTGGACCAAAG
GAAGGAAGCAAGCATCTCCGCATCGCATCCTCTTCCATTAACCAGTGGCCGGTTGCCACTCTCCTCCCCTCCCTCAGAGACACCAAACTG
CCAAAAACAAGACGCGTAGCAGCACACACTTCACAAAGCCAAGCCTAGGCCGCCCTGAGCATCCTGGTTCAAACGGGTGCCTGGTCAGAA
GGCCAGCCGCCCACTTCCCGTTTCCTCTTTAACTGAGGAGAAGCTGATCCAGTTTCCGGAAACAAAATCCTTTTCTCATTTGGGGAGGGG
GGTAATAGTGACATGCAGGCACCTCTTTTAAACAGGCAAAACAGGAAGGGGGAAAAGGTGGGATTCATGTCGAGGCTAGAGGCATTTGGA
ACAACAAATCTACGTAGTTAACTTGAAGAAACCGATTTTTAAAGTTGGTGCATCTAGAAAGCTTTGAATGCAGAAGCAAACAAGCTTGAT
TTTTCTAGCATCCTCTTAATGTGCAGCAAAAGCAGGCGACAAAATCTCCTGGCTTTACAGACAAAAATATTTCAGCAAACGTTGGGCATC
ATGGTTTTTGAAGGCTTTAGTTCTGCTTTCTGCCTCTCCTCCACAGCCCCAACCTCCCACCCCTGATACATGAGCCAGTGATTATTCTTG
TTCAGGGAGAAGATCATTTAGATTTGTTTTGCATTCCTTAGAATGGAGGGCAACATTCCACAGCTGCCCTGGCTGTGATGAGTGTCCTTG
CAGGGGCCGGAGTAGGAGCACTGGGGTGGGGGTGGAATTGGGGTTACTCGATGTAAGGGATTCCTTGTTGTTGTGTTGAGATCCAGTGCA
GTTGTGATTTCTGTGGATCCCAGCTTGGTTCCAGGAATTTTGTGTGATTGGCTTAAATCCAGTTTTCAATCTTCGACAGCTGGGCTGGAA
CGTGAACTCAGTAGCTGAACCTGTCTGACCCGGTCACGTTCTTGGATCCTCAGAACTCTTTGCTCTTGTCGGGGTGGGGGTGGGAACTCA
CGTGGGGAGCGGTGGCTGAGAAAATGTAAGGATTCTGGAATACATATTCCATGGGACTTTCCTTCCCTCTCCTGCTTCCTCTTTTCCTGC
TCCCTAACCTTTCGCCGAATGGGGCAGCACCACTGACGTTTCTGGGCGGCCAGTGCGGCTGCCAGGTTCCTGTACTACTGCCTTGTACTT
TTCATTTTGGCTCACCGTGGATTTTCTCATAGGAAGTTTGGTCAGAGTGAATTGAATATTGTAAGTCAGCCACTGGGACCCGAGGATTTC
TGGGACCCCGCAGTTGGGAGGAGGAAGTAGTCCAGCCTTCCAGGTGGCGTGAGAGGCAATGACTCGTTACCTGCCGCCCATCACCTTGGA
GGCCTTCCCTGGCCTTGAGTAGAAAAGTCGGGGATCGGGGCAAGAGAGGCTGAGTACGGATGGGAAACTATTGTGCACAAGTCTTTCCAG

>24789_24789_2_E2F5-NDRG1_E2F5_chr8_86089889_ENST00000256117_NDRG1_chr8_134276895_ENST00000354944_length(amino acids)=369AA_BP=78
MAAAEPASSGQQAPAGQGQGQRPPPQPPQAQAPQPPPPPQLGGAGGGSSRHEKSLGLLTTKFVSLLQEAKDGVLDLKAEQDIETLHGSVH
VTLCGTPKGNRPVILTYHDIGMNHKTCAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQSNV
EVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQI
SQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNSGAAGNSA

--------------------------------------------------------------
>24789_24789_3_E2F5-NDRG1_E2F5_chr8_86089889_ENST00000416274_NDRG1_chr8_134276895_ENST00000323851_length(transcript)=3061nt_BP=268nt
CGCGGGGGCCCGACCACCGCGGGGCCGGGACGCGATGGCGGCGGCAGAGCCCGCGAGCTCGGGCCAGCAGGCGCCGGCAGGGCAGGGGCA
GGGCCAGCGGCCGCCGCCGCAGCCTCCGCAGGCGCAAGCCCCGCAGCCGCCCCCGCCGCCGCAGCTCGGGGGCGCCGGGGGCGGCAGCAG
CAGGCACGAGAAGAGCCTGGGGCTGCTCACTACCAAGTTCGTGTCGCTGCTGCAGGAGGCCAAGGACGGCGTTCTGGATCTCAAAGCGGA
GCAGGACATCGAGACTTTACATGGCTCTGTTCACGTCACGCTGTGTGGGACTCCCAAGGGAAACCGGCCTGTCATCCTCACCTACCATGA
CATCGGCATGAACCACAAAACCTGCTACAACCCCCTCTTCAACTACGAGGACATGCAGGAGATCACCCAGCACTTTGCCGTCTGCCACGT
GGACGCCCCTGGCCAGCAGGACGGCGCAGCCTCCTTCCCCGCAGGGTACATGTACCCCTCCATGGATCAGCTGGCTGAAATGCTTCCTGG
AGTCCTTCAACAGTTTGGGCTGAAAAGCATTATTGGCATGGGAACAGGAGCAGGCGCCTACATCCTAACTCGATTTGCTCTAAACAACCC
TGAGATGGTGGAGGGCCTTGTCCTTATCAACGTGAACCCTTGTGCGGAAGGCTGGATGGACTGGGCCGCCTCCAAGATCTCAGGATGGAC
CCAAGCTCTGCCGGACATGGTGGTGTCCCACCTTTTTGGGAAGGAAGAAATGCAGAGTAACGTGGAAGTGGTCCACACCTACCGCCAGCA
CATTGTGAATGACATGAACCCCGGCAACCTGCACCTGTTCATCAATGCCTACAACAGCCGGCGCGACCTGGAGATTGAGCGACCAATGCC
GGGAACCCACACAGTCACCCTGCAGTGCCCTGCTCTGTTGGTGGTTGGGGACAGCTCGCCTGCAGTGGATGCCGTGGTGGAGTGCAACTC
AAAATTGGACCCAACAAAGACCACTCTCCTCAAGATGGCGGACTGTGGCGGCCTCCCGCAGATCTCCCAGCCGGCCAAGCTCGCTGAGGC
CTTCAAGTACTTCGTGCAGGGCATGGGATACATGCCCTCGGCTAGCATGACCCGCCTGATGCGGTCCCGCACAGCCTCTGGTTCCAGCGT
CACTTCTCTGGATGGCACCCGCAGCCGCTCCCACACCAGCGAGGGCACCCGAAGCCGCTCCCACACCAGCGAGGGCACCCGCAGCCGCTC
GCACACCAGCGAGGGGGCCCACCTGGACATCACCCCCAACTCGGGTGCTGCTGGGAACAGCGCCGGGCCCAAGTCCATGGAGGTCTCCTG
CTAGGCGGCCTGCCCAGCTGCCGCCCCCGGACTCTGATCTCTGTAGTGGCCCCCTCCTCCCCGGCCCCTTTTCGCCCCCTGCCTGCCATA
CTGCGCCTAACTCGGTATTAATCCAAAGCTTATTTTGTAAGAGTGAGCTCTGGTGGAGACAAATGAGGTCTATTACGTGGGTGCCCTCTC
CAAAGGCGGGGTGGCGGTGGACCAAAGGAAGGAAGCAAGCATCTCCGCATCGCATCCTCTTCCATTAACCAGTGGCCGGTTGCCACTCTC
CTCCCCTCCCTCAGAGACACCAAACTGCCAAAAACAAGACGCGTAGCAGCACACACTTCACAAAGCCAAGCCTAGGCCGCCCTGAGCATC
CTGGTTCAAACGGGTGCCTGGTCAGAAGGCCAGCCGCCCACTTCCCGTTTCCTCTTTAACTGAGGAGAAGCTGATCCAGTTTCCGGAAAC
AAAATCCTTTTCTCATTTGGGGAGGGGGGTAATAGTGACATGCAGGCACCTCTTTTAAACAGGCAAAACAGGAAGGGGGAAAAGGTGGGA
TTCATGTCGAGGCTAGAGGCATTTGGAACAACAAATCTACGTAGTTAACTTGAAGAAACCGATTTTTAAAGTTGGTGCATCTAGAAAGCT
TTGAATGCAGAAGCAAACAAGCTTGATTTTTCTAGCATCCTCTTAATGTGCAGCAAAAGCAGGCGACAAAATCTCCTGGCTTTACAGACA
AAAATATTTCAGCAAACGTTGGGCATCATGGTTTTTGAAGGCTTTAGTTCTGCTTTCTGCCTCTCCTCCACAGCCCCAACCTCCCACCCC
TGATACATGAGCCAGTGATTATTCTTGTTCAGGGAGAAGATCATTTAGATTTGTTTTGCATTCCTTAGAATGGAGGGCAACATTCCACAG
CTGCCCTGGCTGTGATGAGTGTCCTTGCAGGGGCCGGAGTAGGAGCACTGGGGTGGGGGTGGAATTGGGGTTACTCGATGTAAGGGATTC
CTTGTTGTTGTGTTGAGATCCAGTGCAGTTGTGATTTCTGTGGATCCCAGCTTGGTTCCAGGAATTTTGTGTGATTGGCTTAAATCCAGT
TTTCAATCTTCGACAGCTGGGCTGGAACGTGAACTCAGTAGCTGAACCTGTCTGACCCGGTCACGTTCTTGGATCCTCAGAACTCTTTGC
TCTTGTCGGGGTGGGGGTGGGAACTCACGTGGGGAGCGGTGGCTGAGAAAATGTAAGGATTCTGGAATACATATTCCATGGGACTTTCCT
TCCCTCTCCTGCTTCCTCTTTTCCTGCTCCCTAACCTTTCGCCGAATGGGGCAGCACCACTGACGTTTCTGGGCGGCCAGTGCGGCTGCC
AGGTTCCTGTACTACTGCCTTGTACTTTTCATTTTGGCTCACCGTGGATTTTCTCATAGGAAGTTTGGTCAGAGTGAATTGAATATTGTA
AGTCAGCCACTGGGACCCGAGGATTTCTGGGACCCCGCAGTTGGGAGGAGGAAGTAGTCCAGCCTTCCAGGTGGCGTGAGAGGCAATGAC
TCGTTACCTGCCGCCCATCACCTTGGAGGCCTTCCCTGGCCTTGAGTAGAAAAGTCGGGGATCGGGGCAAGAGAGGCTGAGTACGGATGG
GAAACTATTGTGCACAAGTCTTTCCAGAGGAGTTTCTTAATGAGATATTTGTATTTATTTCCAGACCAATAAATTTGTAACTTTGCAGCG

>24789_24789_3_E2F5-NDRG1_E2F5_chr8_86089889_ENST00000416274_NDRG1_chr8_134276895_ENST00000323851_length(amino acids)=439AA_BP=78
MAAAEPASSGQQAPAGQGQGQRPPPQPPQAQAPQPPPPPQLGGAGGGSSRHEKSLGLLTTKFVSLLQEAKDGVLDLKAEQDIETLHGSVH
VTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYPSMDQLAEMLPGVLQQFGLKSII
GMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLH
LFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYM

--------------------------------------------------------------
>24789_24789_4_E2F5-NDRG1_E2F5_chr8_86089889_ENST00000416274_NDRG1_chr8_134276895_ENST00000354944_length(transcript)=2850nt_BP=268nt
CGCGGGGGCCCGACCACCGCGGGGCCGGGACGCGATGGCGGCGGCAGAGCCCGCGAGCTCGGGCCAGCAGGCGCCGGCAGGGCAGGGGCA
GGGCCAGCGGCCGCCGCCGCAGCCTCCGCAGGCGCAAGCCCCGCAGCCGCCCCCGCCGCCGCAGCTCGGGGGCGCCGGGGGCGGCAGCAG
CAGGCACGAGAAGAGCCTGGGGCTGCTCACTACCAAGTTCGTGTCGCTGCTGCAGGAGGCCAAGGACGGCGTTCTGGATCTCAAAGCGGA
GCAGGACATCGAGACTTTACATGGCTCTGTTCACGTCACGCTGTGTGGGACTCCCAAGGGAAACCGGCCTGTCATCCTCACCTACCATGA
CATCGGCATGAACCACAAAACCTGCGCCTACATCCTAACTCGATTTGCTCTAAACAACCCTGAGATGGTGGAGGGCCTTGTCCTTATCAA
CGTGAACCCTTGTGCGGAAGGCTGGATGGACTGGGCCGCCTCCAAGATCTCAGGATGGACCCAAGCTCTGCCGGACATGGTGGTGTCCCA
CCTTTTTGGGAAGGAAGAAATGCAGAGTAACGTGGAAGTGGTCCACACCTACCGCCAGCACATTGTGAATGACATGAACCCCGGCAACCT
GCACCTGTTCATCAATGCCTACAACAGCCGGCGCGACCTGGAGATTGAGCGACCAATGCCGGGAACCCACACAGTCACCCTGCAGTGCCC
TGCTCTGTTGGTGGTTGGGGACAGCTCGCCTGCAGTGGATGCCGTGGTGGAGTGCAACTCAAAATTGGACCCAACAAAGACCACTCTCCT
CAAGATGGCGGACTGTGGCGGCCTCCCGCAGATCTCCCAGCCGGCCAAGCTCGCTGAGGCCTTCAAGTACTTCGTGCAGGGCATGGGATA
CATGCCCTCGGCTAGCATGACCCGCCTGATGCGGTCCCGCACAGCCTCTGGTTCCAGCGTCACTTCTCTGGATGGCACCCGCAGCCGCTC
CCACACCAGCGAGGGCACCCGAAGCCGCTCCCACACCAGCGAGGGCACCCGCAGCCGCTCGCACACCAGCGAGGGGGCCCACCTGGACAT
CACCCCCAACTCGGGTGCTGCTGGGAACAGCGCCGGGCCCAAGTCCATGGAGGTCTCCTGCTAGGCGGCCTGCCCAGCTGCCGCCCCCGG
ACTCTGATCTCTGTAGTGGCCCCCTCCTCCCCGGCCCCTTTTCGCCCCCTGCCTGCCATACTGCGCCTAACTCGGTATTAATCCAAAGCT
TATTTTGTAAGAGTGAGCTCTGGTGGAGACAAATGAGGTCTATTACGTGGGTGCCCTCTCCAAAGGCGGGGTGGCGGTGGACCAAAGGAA
GGAAGCAAGCATCTCCGCATCGCATCCTCTTCCATTAACCAGTGGCCGGTTGCCACTCTCCTCCCCTCCCTCAGAGACACCAAACTGCCA
AAAACAAGACGCGTAGCAGCACACACTTCACAAAGCCAAGCCTAGGCCGCCCTGAGCATCCTGGTTCAAACGGGTGCCTGGTCAGAAGGC
CAGCCGCCCACTTCCCGTTTCCTCTTTAACTGAGGAGAAGCTGATCCAGTTTCCGGAAACAAAATCCTTTTCTCATTTGGGGAGGGGGGT
AATAGTGACATGCAGGCACCTCTTTTAAACAGGCAAAACAGGAAGGGGGAAAAGGTGGGATTCATGTCGAGGCTAGAGGCATTTGGAACA
ACAAATCTACGTAGTTAACTTGAAGAAACCGATTTTTAAAGTTGGTGCATCTAGAAAGCTTTGAATGCAGAAGCAAACAAGCTTGATTTT
TCTAGCATCCTCTTAATGTGCAGCAAAAGCAGGCGACAAAATCTCCTGGCTTTACAGACAAAAATATTTCAGCAAACGTTGGGCATCATG
GTTTTTGAAGGCTTTAGTTCTGCTTTCTGCCTCTCCTCCACAGCCCCAACCTCCCACCCCTGATACATGAGCCAGTGATTATTCTTGTTC
AGGGAGAAGATCATTTAGATTTGTTTTGCATTCCTTAGAATGGAGGGCAACATTCCACAGCTGCCCTGGCTGTGATGAGTGTCCTTGCAG
GGGCCGGAGTAGGAGCACTGGGGTGGGGGTGGAATTGGGGTTACTCGATGTAAGGGATTCCTTGTTGTTGTGTTGAGATCCAGTGCAGTT
GTGATTTCTGTGGATCCCAGCTTGGTTCCAGGAATTTTGTGTGATTGGCTTAAATCCAGTTTTCAATCTTCGACAGCTGGGCTGGAACGT
GAACTCAGTAGCTGAACCTGTCTGACCCGGTCACGTTCTTGGATCCTCAGAACTCTTTGCTCTTGTCGGGGTGGGGGTGGGAACTCACGT
GGGGAGCGGTGGCTGAGAAAATGTAAGGATTCTGGAATACATATTCCATGGGACTTTCCTTCCCTCTCCTGCTTCCTCTTTTCCTGCTCC
CTAACCTTTCGCCGAATGGGGCAGCACCACTGACGTTTCTGGGCGGCCAGTGCGGCTGCCAGGTTCCTGTACTACTGCCTTGTACTTTTC
ATTTTGGCTCACCGTGGATTTTCTCATAGGAAGTTTGGTCAGAGTGAATTGAATATTGTAAGTCAGCCACTGGGACCCGAGGATTTCTGG
GACCCCGCAGTTGGGAGGAGGAAGTAGTCCAGCCTTCCAGGTGGCGTGAGAGGCAATGACTCGTTACCTGCCGCCCATCACCTTGGAGGC
CTTCCCTGGCCTTGAGTAGAAAAGTCGGGGATCGGGGCAAGAGAGGCTGAGTACGGATGGGAAACTATTGTGCACAAGTCTTTCCAGAGG

>24789_24789_4_E2F5-NDRG1_E2F5_chr8_86089889_ENST00000416274_NDRG1_chr8_134276895_ENST00000354944_length(amino acids)=369AA_BP=78
MAAAEPASSGQQAPAGQGQGQRPPPQPPQAQAPQPPPPPQLGGAGGGSSRHEKSLGLLTTKFVSLLQEAKDGVLDLKAEQDIETLHGSVH
VTLCGTPKGNRPVILTYHDIGMNHKTCAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQSNV
EVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQI
SQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNSGAAGNSA

--------------------------------------------------------------
>24789_24789_5_E2F5-NDRG1_E2F5_chr8_86089889_ENST00000418930_NDRG1_chr8_134276895_ENST00000323851_length(transcript)=3223nt_BP=430nt
GCGGAGGCCCGGCGTGACAAGCGGCCCAGACTCCCGTGGGCGCCGCACACCTGTTGTTTGCAGCAGCCAGCGACCCGCACTACCGCTCTC
GGCGGGCGGGGAAGCGGCCGCAGCGGAGCCGACCCGGCAGGTGGCCGCGGGCGGGGCCGGCGAGCGAAAGTGCGCGGGGGCCCGACCACC
GCGGGGCCGGGACGCGATGGCGGCGGCAGAGCCCGCGAGCTCGGGCCAGCAGGCGCCGGCAGGGCAGGGGCAGGGCCAGCGGCCGCCGCC
GCAGCCTCCGCAGGCGCAAGCCCCGCAGCCGCCCCCGCCGCCGCAGCTCGGGGGCGCCGGGGGCGGCAGCAGCAGGCACGAGAAGAGCCT
GGGGCTGCTCACTACCAAGTTCGTGTCGCTGCTGCAGGAGGCCAAGGACGGCGTTCTGGATCTCAAAGCGGAGCAGGACATCGAGACTTT
ACATGGCTCTGTTCACGTCACGCTGTGTGGGACTCCCAAGGGAAACCGGCCTGTCATCCTCACCTACCATGACATCGGCATGAACCACAA
AACCTGCTACAACCCCCTCTTCAACTACGAGGACATGCAGGAGATCACCCAGCACTTTGCCGTCTGCCACGTGGACGCCCCTGGCCAGCA
GGACGGCGCAGCCTCCTTCCCCGCAGGGTACATGTACCCCTCCATGGATCAGCTGGCTGAAATGCTTCCTGGAGTCCTTCAACAGTTTGG
GCTGAAAAGCATTATTGGCATGGGAACAGGAGCAGGCGCCTACATCCTAACTCGATTTGCTCTAAACAACCCTGAGATGGTGGAGGGCCT
TGTCCTTATCAACGTGAACCCTTGTGCGGAAGGCTGGATGGACTGGGCCGCCTCCAAGATCTCAGGATGGACCCAAGCTCTGCCGGACAT
GGTGGTGTCCCACCTTTTTGGGAAGGAAGAAATGCAGAGTAACGTGGAAGTGGTCCACACCTACCGCCAGCACATTGTGAATGACATGAA
CCCCGGCAACCTGCACCTGTTCATCAATGCCTACAACAGCCGGCGCGACCTGGAGATTGAGCGACCAATGCCGGGAACCCACACAGTCAC
CCTGCAGTGCCCTGCTCTGTTGGTGGTTGGGGACAGCTCGCCTGCAGTGGATGCCGTGGTGGAGTGCAACTCAAAATTGGACCCAACAAA
GACCACTCTCCTCAAGATGGCGGACTGTGGCGGCCTCCCGCAGATCTCCCAGCCGGCCAAGCTCGCTGAGGCCTTCAAGTACTTCGTGCA
GGGCATGGGATACATGCCCTCGGCTAGCATGACCCGCCTGATGCGGTCCCGCACAGCCTCTGGTTCCAGCGTCACTTCTCTGGATGGCAC
CCGCAGCCGCTCCCACACCAGCGAGGGCACCCGAAGCCGCTCCCACACCAGCGAGGGCACCCGCAGCCGCTCGCACACCAGCGAGGGGGC
CCACCTGGACATCACCCCCAACTCGGGTGCTGCTGGGAACAGCGCCGGGCCCAAGTCCATGGAGGTCTCCTGCTAGGCGGCCTGCCCAGC
TGCCGCCCCCGGACTCTGATCTCTGTAGTGGCCCCCTCCTCCCCGGCCCCTTTTCGCCCCCTGCCTGCCATACTGCGCCTAACTCGGTAT
TAATCCAAAGCTTATTTTGTAAGAGTGAGCTCTGGTGGAGACAAATGAGGTCTATTACGTGGGTGCCCTCTCCAAAGGCGGGGTGGCGGT
GGACCAAAGGAAGGAAGCAAGCATCTCCGCATCGCATCCTCTTCCATTAACCAGTGGCCGGTTGCCACTCTCCTCCCCTCCCTCAGAGAC
ACCAAACTGCCAAAAACAAGACGCGTAGCAGCACACACTTCACAAAGCCAAGCCTAGGCCGCCCTGAGCATCCTGGTTCAAACGGGTGCC
TGGTCAGAAGGCCAGCCGCCCACTTCCCGTTTCCTCTTTAACTGAGGAGAAGCTGATCCAGTTTCCGGAAACAAAATCCTTTTCTCATTT
GGGGAGGGGGGTAATAGTGACATGCAGGCACCTCTTTTAAACAGGCAAAACAGGAAGGGGGAAAAGGTGGGATTCATGTCGAGGCTAGAG
GCATTTGGAACAACAAATCTACGTAGTTAACTTGAAGAAACCGATTTTTAAAGTTGGTGCATCTAGAAAGCTTTGAATGCAGAAGCAAAC
AAGCTTGATTTTTCTAGCATCCTCTTAATGTGCAGCAAAAGCAGGCGACAAAATCTCCTGGCTTTACAGACAAAAATATTTCAGCAAACG
TTGGGCATCATGGTTTTTGAAGGCTTTAGTTCTGCTTTCTGCCTCTCCTCCACAGCCCCAACCTCCCACCCCTGATACATGAGCCAGTGA
TTATTCTTGTTCAGGGAGAAGATCATTTAGATTTGTTTTGCATTCCTTAGAATGGAGGGCAACATTCCACAGCTGCCCTGGCTGTGATGA
GTGTCCTTGCAGGGGCCGGAGTAGGAGCACTGGGGTGGGGGTGGAATTGGGGTTACTCGATGTAAGGGATTCCTTGTTGTTGTGTTGAGA
TCCAGTGCAGTTGTGATTTCTGTGGATCCCAGCTTGGTTCCAGGAATTTTGTGTGATTGGCTTAAATCCAGTTTTCAATCTTCGACAGCT
GGGCTGGAACGTGAACTCAGTAGCTGAACCTGTCTGACCCGGTCACGTTCTTGGATCCTCAGAACTCTTTGCTCTTGTCGGGGTGGGGGT
GGGAACTCACGTGGGGAGCGGTGGCTGAGAAAATGTAAGGATTCTGGAATACATATTCCATGGGACTTTCCTTCCCTCTCCTGCTTCCTC
TTTTCCTGCTCCCTAACCTTTCGCCGAATGGGGCAGCACCACTGACGTTTCTGGGCGGCCAGTGCGGCTGCCAGGTTCCTGTACTACTGC
CTTGTACTTTTCATTTTGGCTCACCGTGGATTTTCTCATAGGAAGTTTGGTCAGAGTGAATTGAATATTGTAAGTCAGCCACTGGGACCC
GAGGATTTCTGGGACCCCGCAGTTGGGAGGAGGAAGTAGTCCAGCCTTCCAGGTGGCGTGAGAGGCAATGACTCGTTACCTGCCGCCCAT
CACCTTGGAGGCCTTCCCTGGCCTTGAGTAGAAAAGTCGGGGATCGGGGCAAGAGAGGCTGAGTACGGATGGGAAACTATTGTGCACAAG

>24789_24789_5_E2F5-NDRG1_E2F5_chr8_86089889_ENST00000418930_NDRG1_chr8_134276895_ENST00000323851_length(amino acids)=439AA_BP=78
MAAAEPASSGQQAPAGQGQGQRPPPQPPQAQAPQPPPPPQLGGAGGGSSRHEKSLGLLTTKFVSLLQEAKDGVLDLKAEQDIETLHGSVH
VTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYPSMDQLAEMLPGVLQQFGLKSII
GMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLH
LFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYM

--------------------------------------------------------------
>24789_24789_6_E2F5-NDRG1_E2F5_chr8_86089889_ENST00000418930_NDRG1_chr8_134276895_ENST00000354944_length(transcript)=3012nt_BP=430nt
GCGGAGGCCCGGCGTGACAAGCGGCCCAGACTCCCGTGGGCGCCGCACACCTGTTGTTTGCAGCAGCCAGCGACCCGCACTACCGCTCTC
GGCGGGCGGGGAAGCGGCCGCAGCGGAGCCGACCCGGCAGGTGGCCGCGGGCGGGGCCGGCGAGCGAAAGTGCGCGGGGGCCCGACCACC
GCGGGGCCGGGACGCGATGGCGGCGGCAGAGCCCGCGAGCTCGGGCCAGCAGGCGCCGGCAGGGCAGGGGCAGGGCCAGCGGCCGCCGCC
GCAGCCTCCGCAGGCGCAAGCCCCGCAGCCGCCCCCGCCGCCGCAGCTCGGGGGCGCCGGGGGCGGCAGCAGCAGGCACGAGAAGAGCCT
GGGGCTGCTCACTACCAAGTTCGTGTCGCTGCTGCAGGAGGCCAAGGACGGCGTTCTGGATCTCAAAGCGGAGCAGGACATCGAGACTTT
ACATGGCTCTGTTCACGTCACGCTGTGTGGGACTCCCAAGGGAAACCGGCCTGTCATCCTCACCTACCATGACATCGGCATGAACCACAA
AACCTGCGCCTACATCCTAACTCGATTTGCTCTAAACAACCCTGAGATGGTGGAGGGCCTTGTCCTTATCAACGTGAACCCTTGTGCGGA
AGGCTGGATGGACTGGGCCGCCTCCAAGATCTCAGGATGGACCCAAGCTCTGCCGGACATGGTGGTGTCCCACCTTTTTGGGAAGGAAGA
AATGCAGAGTAACGTGGAAGTGGTCCACACCTACCGCCAGCACATTGTGAATGACATGAACCCCGGCAACCTGCACCTGTTCATCAATGC
CTACAACAGCCGGCGCGACCTGGAGATTGAGCGACCAATGCCGGGAACCCACACAGTCACCCTGCAGTGCCCTGCTCTGTTGGTGGTTGG
GGACAGCTCGCCTGCAGTGGATGCCGTGGTGGAGTGCAACTCAAAATTGGACCCAACAAAGACCACTCTCCTCAAGATGGCGGACTGTGG
CGGCCTCCCGCAGATCTCCCAGCCGGCCAAGCTCGCTGAGGCCTTCAAGTACTTCGTGCAGGGCATGGGATACATGCCCTCGGCTAGCAT
GACCCGCCTGATGCGGTCCCGCACAGCCTCTGGTTCCAGCGTCACTTCTCTGGATGGCACCCGCAGCCGCTCCCACACCAGCGAGGGCAC
CCGAAGCCGCTCCCACACCAGCGAGGGCACCCGCAGCCGCTCGCACACCAGCGAGGGGGCCCACCTGGACATCACCCCCAACTCGGGTGC
TGCTGGGAACAGCGCCGGGCCCAAGTCCATGGAGGTCTCCTGCTAGGCGGCCTGCCCAGCTGCCGCCCCCGGACTCTGATCTCTGTAGTG
GCCCCCTCCTCCCCGGCCCCTTTTCGCCCCCTGCCTGCCATACTGCGCCTAACTCGGTATTAATCCAAAGCTTATTTTGTAAGAGTGAGC
TCTGGTGGAGACAAATGAGGTCTATTACGTGGGTGCCCTCTCCAAAGGCGGGGTGGCGGTGGACCAAAGGAAGGAAGCAAGCATCTCCGC
ATCGCATCCTCTTCCATTAACCAGTGGCCGGTTGCCACTCTCCTCCCCTCCCTCAGAGACACCAAACTGCCAAAAACAAGACGCGTAGCA
GCACACACTTCACAAAGCCAAGCCTAGGCCGCCCTGAGCATCCTGGTTCAAACGGGTGCCTGGTCAGAAGGCCAGCCGCCCACTTCCCGT
TTCCTCTTTAACTGAGGAGAAGCTGATCCAGTTTCCGGAAACAAAATCCTTTTCTCATTTGGGGAGGGGGGTAATAGTGACATGCAGGCA
CCTCTTTTAAACAGGCAAAACAGGAAGGGGGAAAAGGTGGGATTCATGTCGAGGCTAGAGGCATTTGGAACAACAAATCTACGTAGTTAA
CTTGAAGAAACCGATTTTTAAAGTTGGTGCATCTAGAAAGCTTTGAATGCAGAAGCAAACAAGCTTGATTTTTCTAGCATCCTCTTAATG
TGCAGCAAAAGCAGGCGACAAAATCTCCTGGCTTTACAGACAAAAATATTTCAGCAAACGTTGGGCATCATGGTTTTTGAAGGCTTTAGT
TCTGCTTTCTGCCTCTCCTCCACAGCCCCAACCTCCCACCCCTGATACATGAGCCAGTGATTATTCTTGTTCAGGGAGAAGATCATTTAG
ATTTGTTTTGCATTCCTTAGAATGGAGGGCAACATTCCACAGCTGCCCTGGCTGTGATGAGTGTCCTTGCAGGGGCCGGAGTAGGAGCAC
TGGGGTGGGGGTGGAATTGGGGTTACTCGATGTAAGGGATTCCTTGTTGTTGTGTTGAGATCCAGTGCAGTTGTGATTTCTGTGGATCCC
AGCTTGGTTCCAGGAATTTTGTGTGATTGGCTTAAATCCAGTTTTCAATCTTCGACAGCTGGGCTGGAACGTGAACTCAGTAGCTGAACC
TGTCTGACCCGGTCACGTTCTTGGATCCTCAGAACTCTTTGCTCTTGTCGGGGTGGGGGTGGGAACTCACGTGGGGAGCGGTGGCTGAGA
AAATGTAAGGATTCTGGAATACATATTCCATGGGACTTTCCTTCCCTCTCCTGCTTCCTCTTTTCCTGCTCCCTAACCTTTCGCCGAATG
GGGCAGCACCACTGACGTTTCTGGGCGGCCAGTGCGGCTGCCAGGTTCCTGTACTACTGCCTTGTACTTTTCATTTTGGCTCACCGTGGA
TTTTCTCATAGGAAGTTTGGTCAGAGTGAATTGAATATTGTAAGTCAGCCACTGGGACCCGAGGATTTCTGGGACCCCGCAGTTGGGAGG
AGGAAGTAGTCCAGCCTTCCAGGTGGCGTGAGAGGCAATGACTCGTTACCTGCCGCCCATCACCTTGGAGGCCTTCCCTGGCCTTGAGTA
GAAAAGTCGGGGATCGGGGCAAGAGAGGCTGAGTACGGATGGGAAACTATTGTGCACAAGTCTTTCCAGAGGAGTTTCTTAATGAGATAT

>24789_24789_6_E2F5-NDRG1_E2F5_chr8_86089889_ENST00000418930_NDRG1_chr8_134276895_ENST00000354944_length(amino acids)=369AA_BP=78
MAAAEPASSGQQAPAGQGQGQRPPPQPPQAQAPQPPPPPQLGGAGGGSSRHEKSLGLLTTKFVSLLQEAKDGVLDLKAEQDIETLHGSVH
VTLCGTPKGNRPVILTYHDIGMNHKTCAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQSNV
EVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQI
SQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNSGAAGNSA

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Fusion Gene PPI Analysis for E2F5-NDRG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for E2F5-NDRG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for E2F5-NDRG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneE2F5C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneE2F5C0235874Disease Exacerbation1CTD_human
TgeneC0027627Neoplasm Metastasis2CTD_human
TgeneC1832334CHARCOT-MARIE-TOOTH DISEASE, TYPE 4D2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0004114Astrocytoma1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneC0007134Renal Cell Carcinoma1CTD_human
TgeneC0017636Glioblastoma1CTD_human
TgeneC0022665Kidney Neoplasm1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0023903Liver neoplasms1CTD_human
TgeneC0025202melanoma1CTD_human
TgeneC0026640Mouth Neoplasms1CTD_human
TgeneC0029295Oropharyngeal Neoplasms1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0149925Small cell carcinoma of lung1CTD_human
TgeneC0153381Malignant neoplasm of mouth1CTD_human
TgeneC0205768Subependymal Giant Cell Astrocytoma1CTD_human
TgeneC0206658Smooth Muscle Tumor1CTD_human
TgeneC0206734Hemangioblastoma1CTD_human
TgeneC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneC0280783Juvenile Pilocytic Astrocytoma1CTD_human
TgeneC0280785Diffuse Astrocytoma1CTD_human
TgeneC0334579Anaplastic astrocytoma1CTD_human
TgeneC0334580Protoplasmic astrocytoma1CTD_human
TgeneC0334581Gemistocytic astrocytoma1CTD_human
TgeneC0334582Fibrillary Astrocytoma1CTD_human
TgeneC0334583Pilocytic Astrocytoma1CTD_human
TgeneC0334588Giant Cell Glioblastoma1CTD_human
TgeneC0338070Childhood Cerebral Astrocytoma1CTD_human
TgeneC0345904Malignant neoplasm of liver1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC0547065Mixed oligoastrocytoma1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0740457Malignant neoplasm of kidney1CTD_human
TgeneC0750935Cerebral Astrocytoma1CTD_human
TgeneC0750936Intracranial Astrocytoma1CTD_human
TgeneC0751692Multiple Hemangioblastomas1CTD_human
TgeneC0887833Carcinoma, Pancreatic Ductal1CTD_human
TgeneC1168401Squamous cell carcinoma of the head and neck1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneC1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1621958Glioblastoma Multiforme1CTD_human
TgeneC1704230Grade I Astrocytoma1CTD_human
TgeneC2349952Oropharyngeal Carcinoma1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human