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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EGFR-VOPP1 (FusionGDB2 ID:HG1956TG81552)

Fusion Gene Summary for EGFR-VOPP1

check button Fusion gene summary
Fusion gene informationFusion gene name: EGFR-VOPP1
Fusion gene ID: hg1956tg81552
HgeneTgene
Gene symbol

EGFR

VOPP1

Gene ID

1956

81552

Gene nameepidermal growth factor receptorVOPP1 WW domain binding protein
SynonymsERBB|ERBB1|HER1|NISBD2|PIG61|mENAECOP|GASP|WBP1L2
Cytomap('EGFR')('VOPP1')

7p11.2

7p11.2

Type of geneprotein-codingprotein-coding
Descriptionepidermal growth factor receptoravian erythroblastic leukemia viral (v-erb-b) oncogene homologcell growth inhibiting protein 40cell proliferation-inducing protein 61epidermal growth factor receptor tyrosine kinase domainerb-b2 receptor tyrosine kinasvesicular, overexpressed in cancer, prosurvival protein 1EGFR-coamplified and overexpressed proteinGlioblastoma-amplified secreted proteinVOPP1, WBP1/VOPP1 family memberhypothetical protein DKFZp564K0822putative NF-kappa-B-activating protein 055N
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000463948, ENST00000275493, 
ENST00000342916, ENST00000344576, 
ENST00000420316, ENST00000442591, 
ENST00000454757, ENST00000455089, 
Fusion gene scores* DoF score41 X 25 X 14=1435010 X 6 X 7=420
# samples 5313
** MAII scorelog2(53/14350*10)=-4.75891456699985
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/420*10)=-1.69187770463767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EGFR [Title/Abstract] AND VOPP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEGFR(55087058)-VOPP1(55588823), # samples:3
Anticipated loss of major functional domain due to fusion event.EGFR-VOPP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EGFR-VOPP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EGFR-VOPP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EGFR-VOPP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EGFR-VOPP1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
EGFR-VOPP1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
EGFR-VOPP1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEGFR

GO:0001934

positive regulation of protein phosphorylation

20551055

HgeneEGFR

GO:0007165

signal transduction

10572067

HgeneEGFR

GO:0007166

cell surface receptor signaling pathway

7736574

HgeneEGFR

GO:0007173

epidermal growth factor receptor signaling pathway

7736574|12435727

HgeneEGFR

GO:0008283

cell proliferation

17115032

HgeneEGFR

GO:0008284

positive regulation of cell proliferation

7736574

HgeneEGFR

GO:0010750

positive regulation of nitric oxide mediated signal transduction

12828935

HgeneEGFR

GO:0018108

peptidyl-tyrosine phosphorylation

22732145

HgeneEGFR

GO:0030307

positive regulation of cell growth

15467833

HgeneEGFR

GO:0042177

negative regulation of protein catabolic process

17115032

HgeneEGFR

GO:0042327

positive regulation of phosphorylation

15082764

HgeneEGFR

GO:0043406

positive regulation of MAP kinase activity

10572067

HgeneEGFR

GO:0045739

positive regulation of DNA repair

17115032

HgeneEGFR

GO:0045740

positive regulation of DNA replication

17115032

HgeneEGFR

GO:0045944

positive regulation of transcription by RNA polymerase II

20551055

HgeneEGFR

GO:0050679

positive regulation of epithelial cell proliferation

10572067

HgeneEGFR

GO:0050999

regulation of nitric-oxide synthase activity

12828935

HgeneEGFR

GO:0070141

response to UV-A

18483258

HgeneEGFR

GO:0070374

positive regulation of ERK1 and ERK2 cascade

20551055

HgeneEGFR

GO:0071392

cellular response to estradiol stimulus

20551055

HgeneEGFR

GO:1900020

positive regulation of protein kinase C activity

22732145

HgeneEGFR

GO:1903078

positive regulation of protein localization to plasma membrane

22732145


check buttonFusion gene breakpoints across EGFR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across VOPP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A4OJEGFRchr7

55087058

+VOPP1chr7

55588823

-
ChimerDB4GBMTCGA-28-2514-01AEGFRchr7

55268106

+VOPP1chr7

55588823

-
ChimerDB4LUADTCGA-55-8089-01AEGFRchr7

55087058

+VOPP1chr7

55588823

-
ChimerDB4LUADTCGA-55-8089EGFRchr7

55087058

+VOPP1chr7

55588823

-


Top

Fusion Gene ORF analysis for EGFR-VOPP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000463948ENST00000285279EGFRchr7

55087058

+VOPP1chr7

55588823

-
3UTR-3CDSENST00000463948ENST00000433959EGFRchr7

55087058

+VOPP1chr7

55588823

-
3UTR-3CDSENST00000463948ENST00000545390EGFRchr7

55087058

+VOPP1chr7

55588823

-
3UTR-5UTRENST00000463948ENST00000418904EGFRchr7

55087058

+VOPP1chr7

55588823

-
3UTR-5UTRENST00000463948ENST00000428097EGFRchr7

55087058

+VOPP1chr7

55588823

-
3UTR-5UTRENST00000463948ENST00000428648EGFRchr7

55087058

+VOPP1chr7

55588823

-
3UTR-5UTRENST00000463948ENST00000454227EGFRchr7

55087058

+VOPP1chr7

55588823

-
3UTR-5UTRENST00000463948ENST00000471168EGFRchr7

55087058

+VOPP1chr7

55588823

-
3UTR-intronENST00000463948ENST00000427700EGFRchr7

55087058

+VOPP1chr7

55588823

-
3UTR-intronENST00000463948ENST00000453256EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000275493ENST00000418904EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000275493ENST00000418904EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000275493ENST00000428097EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000275493ENST00000428097EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000275493ENST00000428648EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000275493ENST00000428648EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000275493ENST00000454227EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000275493ENST00000454227EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000275493ENST00000471168EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000275493ENST00000471168EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000342916ENST00000418904EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000342916ENST00000428097EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000342916ENST00000428648EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000342916ENST00000454227EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000342916ENST00000471168EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000344576ENST00000418904EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000344576ENST00000428097EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000344576ENST00000428648EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000344576ENST00000454227EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000344576ENST00000471168EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000420316ENST00000418904EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000420316ENST00000428097EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000420316ENST00000428648EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000420316ENST00000454227EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000420316ENST00000471168EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000442591ENST00000418904EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000442591ENST00000428097EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000442591ENST00000428648EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000442591ENST00000454227EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000442591ENST00000471168EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000454757ENST00000418904EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000454757ENST00000428097EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000454757ENST00000428648EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000454757ENST00000454227EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000454757ENST00000471168EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000455089ENST00000418904EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000455089ENST00000418904EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000455089ENST00000428097EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000455089ENST00000428097EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000455089ENST00000428648EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000455089ENST00000428648EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000455089ENST00000454227EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000455089ENST00000454227EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000455089ENST00000471168EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-5UTRENST00000455089ENST00000471168EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-intronENST00000275493ENST00000427700EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-intronENST00000275493ENST00000427700EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-intronENST00000275493ENST00000453256EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-intronENST00000275493ENST00000453256EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-intronENST00000342916ENST00000427700EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-intronENST00000342916ENST00000453256EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-intronENST00000344576ENST00000427700EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-intronENST00000344576ENST00000453256EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-intronENST00000420316ENST00000427700EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-intronENST00000420316ENST00000453256EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-intronENST00000442591ENST00000427700EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-intronENST00000442591ENST00000453256EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-intronENST00000454757ENST00000427700EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-intronENST00000454757ENST00000453256EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-intronENST00000455089ENST00000427700EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-intronENST00000455089ENST00000427700EGFRchr7

55268106

+VOPP1chr7

55588823

-
5CDS-intronENST00000455089ENST00000453256EGFRchr7

55087058

+VOPP1chr7

55588823

-
5CDS-intronENST00000455089ENST00000453256EGFRchr7

55268106

+VOPP1chr7

55588823

-
Frame-shiftENST00000275493ENST00000285279EGFRchr7

55087058

+VOPP1chr7

55588823

-
Frame-shiftENST00000275493ENST00000433959EGFRchr7

55087058

+VOPP1chr7

55588823

-
Frame-shiftENST00000275493ENST00000545390EGFRchr7

55087058

+VOPP1chr7

55588823

-
Frame-shiftENST00000342916ENST00000285279EGFRchr7

55087058

+VOPP1chr7

55588823

-
Frame-shiftENST00000342916ENST00000433959EGFRchr7

55087058

+VOPP1chr7

55588823

-
Frame-shiftENST00000342916ENST00000545390EGFRchr7

55087058

+VOPP1chr7

55588823

-
Frame-shiftENST00000344576ENST00000285279EGFRchr7

55087058

+VOPP1chr7

55588823

-
Frame-shiftENST00000344576ENST00000433959EGFRchr7

55087058

+VOPP1chr7

55588823

-
Frame-shiftENST00000344576ENST00000545390EGFRchr7

55087058

+VOPP1chr7

55588823

-
Frame-shiftENST00000420316ENST00000285279EGFRchr7

55087058

+VOPP1chr7

55588823

-
Frame-shiftENST00000420316ENST00000433959EGFRchr7

55087058

+VOPP1chr7

55588823

-
Frame-shiftENST00000420316ENST00000545390EGFRchr7

55087058

+VOPP1chr7

55588823

-
Frame-shiftENST00000442591ENST00000285279EGFRchr7

55087058

+VOPP1chr7

55588823

-
Frame-shiftENST00000442591ENST00000433959EGFRchr7

55087058

+VOPP1chr7

55588823

-
Frame-shiftENST00000442591ENST00000545390EGFRchr7

55087058

+VOPP1chr7

55588823

-
Frame-shiftENST00000455089ENST00000285279EGFRchr7

55087058

+VOPP1chr7

55588823

-
Frame-shiftENST00000455089ENST00000433959EGFRchr7

55087058

+VOPP1chr7

55588823

-
Frame-shiftENST00000455089ENST00000545390EGFRchr7

55087058

+VOPP1chr7

55588823

-
In-frameENST00000275493ENST00000285279EGFRchr7

55268106

+VOPP1chr7

55588823

-
In-frameENST00000275493ENST00000433959EGFRchr7

55268106

+VOPP1chr7

55588823

-
In-frameENST00000275493ENST00000545390EGFRchr7

55268106

+VOPP1chr7

55588823

-
In-frameENST00000454757ENST00000285279EGFRchr7

55268106

+VOPP1chr7

55588823

-
In-frameENST00000454757ENST00000433959EGFRchr7

55268106

+VOPP1chr7

55588823

-
In-frameENST00000454757ENST00000545390EGFRchr7

55268106

+VOPP1chr7

55588823

-
In-frameENST00000455089ENST00000285279EGFRchr7

55268106

+VOPP1chr7

55588823

-
In-frameENST00000455089ENST00000433959EGFRchr7

55268106

+VOPP1chr7

55588823

-
In-frameENST00000455089ENST00000545390EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-3CDSENST00000342916ENST00000285279EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-3CDSENST00000342916ENST00000433959EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-3CDSENST00000342916ENST00000545390EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-3CDSENST00000344576ENST00000285279EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-3CDSENST00000344576ENST00000433959EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-3CDSENST00000344576ENST00000545390EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-3CDSENST00000420316ENST00000285279EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-3CDSENST00000420316ENST00000433959EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-3CDSENST00000420316ENST00000545390EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-3CDSENST00000442591ENST00000285279EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-3CDSENST00000442591ENST00000433959EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-3CDSENST00000442591ENST00000545390EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-3CDSENST00000454757ENST00000285279EGFRchr7

55087058

+VOPP1chr7

55588823

-
intron-3CDSENST00000454757ENST00000433959EGFRchr7

55087058

+VOPP1chr7

55588823

-
intron-3CDSENST00000454757ENST00000545390EGFRchr7

55087058

+VOPP1chr7

55588823

-
intron-3CDSENST00000463948ENST00000285279EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-3CDSENST00000463948ENST00000433959EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-3CDSENST00000463948ENST00000545390EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000342916ENST00000418904EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000342916ENST00000428097EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000342916ENST00000428648EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000342916ENST00000454227EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000342916ENST00000471168EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000344576ENST00000418904EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000344576ENST00000428097EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000344576ENST00000428648EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000344576ENST00000454227EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000344576ENST00000471168EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000420316ENST00000418904EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000420316ENST00000428097EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000420316ENST00000428648EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000420316ENST00000454227EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000420316ENST00000471168EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000442591ENST00000418904EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000442591ENST00000428097EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000442591ENST00000428648EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000442591ENST00000454227EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000442591ENST00000471168EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000454757ENST00000418904EGFRchr7

55087058

+VOPP1chr7

55588823

-
intron-5UTRENST00000454757ENST00000428097EGFRchr7

55087058

+VOPP1chr7

55588823

-
intron-5UTRENST00000454757ENST00000428648EGFRchr7

55087058

+VOPP1chr7

55588823

-
intron-5UTRENST00000454757ENST00000454227EGFRchr7

55087058

+VOPP1chr7

55588823

-
intron-5UTRENST00000454757ENST00000471168EGFRchr7

55087058

+VOPP1chr7

55588823

-
intron-5UTRENST00000463948ENST00000418904EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000463948ENST00000428097EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000463948ENST00000428648EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000463948ENST00000454227EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-5UTRENST00000463948ENST00000471168EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-intronENST00000342916ENST00000427700EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-intronENST00000342916ENST00000453256EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-intronENST00000344576ENST00000427700EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-intronENST00000344576ENST00000453256EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-intronENST00000420316ENST00000427700EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-intronENST00000420316ENST00000453256EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-intronENST00000442591ENST00000427700EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-intronENST00000442591ENST00000453256EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-intronENST00000454757ENST00000427700EGFRchr7

55087058

+VOPP1chr7

55588823

-
intron-intronENST00000454757ENST00000453256EGFRchr7

55087058

+VOPP1chr7

55588823

-
intron-intronENST00000463948ENST00000427700EGFRchr7

55268106

+VOPP1chr7

55588823

-
intron-intronENST00000463948ENST00000453256EGFRchr7

55268106

+VOPP1chr7

55588823

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000455089EGFRchr755268106+ENST00000285279VOPP1chr755588823-5775306825735321091
ENST00000455089EGFRchr755268106+ENST00000433959VOPP1chr755588823-5774306825735321091
ENST00000455089EGFRchr755268106+ENST00000545390VOPP1chr755588823-5774306825735321091
ENST00000275493EGFRchr755268106+ENST00000285279VOPP1chr755588823-5830312317735871136
ENST00000275493EGFRchr755268106+ENST00000433959VOPP1chr755588823-5829312317735871136
ENST00000275493EGFRchr755268106+ENST00000545390VOPP1chr755588823-5829312317735871136
ENST00000454757EGFRchr755268106+ENST00000285279VOPP1chr755588823-5677297014434341096
ENST00000454757EGFRchr755268106+ENST00000433959VOPP1chr755588823-5676297014434341096
ENST00000454757EGFRchr755268106+ENST00000545390VOPP1chr755588823-5676297014434341096

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000455089ENST00000285279EGFRchr755268106+VOPP1chr755588823-0.0005963330.9994037
ENST00000455089ENST00000433959EGFRchr755268106+VOPP1chr755588823-0.0005945410.9994055
ENST00000455089ENST00000545390EGFRchr755268106+VOPP1chr755588823-0.0005945410.9994055
ENST00000275493ENST00000285279EGFRchr755268106+VOPP1chr755588823-0.0005113730.9994886
ENST00000275493ENST00000433959EGFRchr755268106+VOPP1chr755588823-0.000509840.99949014
ENST00000275493ENST00000545390EGFRchr755268106+VOPP1chr755588823-0.000509840.99949014
ENST00000454757ENST00000285279EGFRchr755268106+VOPP1chr755588823-0.0004242610.9995758
ENST00000454757ENST00000433959EGFRchr755268106+VOPP1chr755588823-0.0004229750.999577
ENST00000454757ENST00000545390EGFRchr755268106+VOPP1chr755588823-0.0004229750.999577

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Fusion Genomic Features for EGFR-VOPP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for EGFR-VOPP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:55087058/chr7:55588823)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEGFRchr7:55268106chr7:55588823ENST00000275493+2428712_9799821211.0DomainProtein kinase
HgeneEGFRchr7:55268106chr7:55588823ENST00000275493+2428718_7269821211.0Nucleotide bindingATP
HgeneEGFRchr7:55268106chr7:55588823ENST00000275493+2428790_7919821211.0Nucleotide bindingATP
HgeneEGFRchr7:55268106chr7:55588823ENST00000275493+2428688_7049821211.0RegionNote=Important for dimerization%2C phosphorylation and activation
HgeneEGFRchr7:55268106chr7:55588823ENST00000275493+2428390_6009821211.0RepeatNote=Approximate
HgeneEGFRchr7:55268106chr7:55588823ENST00000275493+242875_3009821211.0RepeatNote=Approximate
HgeneEGFRchr7:55268106chr7:55588823ENST00000275493+242825_6459821211.0Topological domainExtracellular
HgeneEGFRchr7:55268106chr7:55588823ENST00000275493+2428646_6689821211.0TransmembraneHelical
TgeneVOPP1chr7:55268106chr7:55588823ENST000002852790587_16418173.0Compositional biasNote=Pro-rich
TgeneVOPP1chr7:55268106chr7:55588823ENST000004339590587_1649164.0Compositional biasNote=Pro-rich
TgeneVOPP1chr7:55268106chr7:55588823ENST000005453900587_16415170.0Compositional biasNote=Pro-rich
TgeneVOPP1chr7:55268106chr7:55588823ENST000002852790523_6018173.0Topological domainExtracellular
TgeneVOPP1chr7:55268106chr7:55588823ENST000002852790582_17218173.0Topological domainCytoplasmic
TgeneVOPP1chr7:55268106chr7:55588823ENST000004339590523_609164.0Topological domainExtracellular
TgeneVOPP1chr7:55268106chr7:55588823ENST000004339590582_1729164.0Topological domainCytoplasmic
TgeneVOPP1chr7:55268106chr7:55588823ENST000005453900523_6015170.0Topological domainExtracellular
TgeneVOPP1chr7:55268106chr7:55588823ENST000005453900582_17215170.0Topological domainCytoplasmic
TgeneVOPP1chr7:55268106chr7:55588823ENST000002852790561_8118173.0TransmembraneHelical
TgeneVOPP1chr7:55268106chr7:55588823ENST000004339590561_819164.0TransmembraneHelical
TgeneVOPP1chr7:55268106chr7:55588823ENST000005453900561_8115170.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEGFRchr7:55268106chr7:55588823ENST00000342916+116712_9790629.0DomainProtein kinase
HgeneEGFRchr7:55268106chr7:55588823ENST00000344576+116712_9790706.0DomainProtein kinase
HgeneEGFRchr7:55268106chr7:55588823ENST00000420316+110712_9790406.0DomainProtein kinase
HgeneEGFRchr7:55268106chr7:55588823ENST00000342916+116718_7260629.0Nucleotide bindingATP
HgeneEGFRchr7:55268106chr7:55588823ENST00000342916+116790_7910629.0Nucleotide bindingATP
HgeneEGFRchr7:55268106chr7:55588823ENST00000344576+116718_7260706.0Nucleotide bindingATP
HgeneEGFRchr7:55268106chr7:55588823ENST00000344576+116790_7910706.0Nucleotide bindingATP
HgeneEGFRchr7:55268106chr7:55588823ENST00000420316+110718_7260406.0Nucleotide bindingATP
HgeneEGFRchr7:55268106chr7:55588823ENST00000420316+110790_7910406.0Nucleotide bindingATP
HgeneEGFRchr7:55268106chr7:55588823ENST00000342916+116688_7040629.0RegionNote=Important for dimerization%2C phosphorylation and activation
HgeneEGFRchr7:55268106chr7:55588823ENST00000344576+116688_7040706.0RegionNote=Important for dimerization%2C phosphorylation and activation
HgeneEGFRchr7:55268106chr7:55588823ENST00000420316+110688_7040406.0RegionNote=Important for dimerization%2C phosphorylation and activation
HgeneEGFRchr7:55268106chr7:55588823ENST00000342916+116390_6000629.0RepeatNote=Approximate
HgeneEGFRchr7:55268106chr7:55588823ENST00000342916+11675_3000629.0RepeatNote=Approximate
HgeneEGFRchr7:55268106chr7:55588823ENST00000344576+116390_6000706.0RepeatNote=Approximate
HgeneEGFRchr7:55268106chr7:55588823ENST00000344576+11675_3000706.0RepeatNote=Approximate
HgeneEGFRchr7:55268106chr7:55588823ENST00000420316+110390_6000406.0RepeatNote=Approximate
HgeneEGFRchr7:55268106chr7:55588823ENST00000420316+11075_3000406.0RepeatNote=Approximate
HgeneEGFRchr7:55268106chr7:55588823ENST00000275493+2428669_12109821211.0Topological domainCytoplasmic
HgeneEGFRchr7:55268106chr7:55588823ENST00000342916+11625_6450629.0Topological domainExtracellular
HgeneEGFRchr7:55268106chr7:55588823ENST00000342916+116669_12100629.0Topological domainCytoplasmic
HgeneEGFRchr7:55268106chr7:55588823ENST00000344576+11625_6450706.0Topological domainExtracellular
HgeneEGFRchr7:55268106chr7:55588823ENST00000344576+116669_12100706.0Topological domainCytoplasmic
HgeneEGFRchr7:55268106chr7:55588823ENST00000420316+11025_6450406.0Topological domainExtracellular
HgeneEGFRchr7:55268106chr7:55588823ENST00000420316+110669_12100406.0Topological domainCytoplasmic
HgeneEGFRchr7:55268106chr7:55588823ENST00000342916+116646_6680629.0TransmembraneHelical
HgeneEGFRchr7:55268106chr7:55588823ENST00000344576+116646_6680706.0TransmembraneHelical
HgeneEGFRchr7:55268106chr7:55588823ENST00000420316+110646_6680406.0TransmembraneHelical


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Fusion Gene Sequence for EGFR-VOPP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>25487_25487_1_EGFR-VOPP1_EGFR_chr7_55268106_ENST00000275493_VOPP1_chr7_55588823_ENST00000285279_length(transcript)=5830nt_BP=3123nt
GCCGGAGTCCCGAGCTAGCCCCGGCGGCCGCCGCCGCCCAGACCGGACGACAGGCCACCTCGTCGGCGTCCGCCCGAGTCCCCGCCTCGC
CGCCAACGCCACAACCACCGCGCACGGCCCCCTGACTCCGTCCAGTATTGATCGGGAGAGCCGGAGCGAGCTCTTCGGGGAGCAGCGATG
CGACCCTCCGGGACGGCCGGGGCAGCGCTCCTGGCGCTGCTGGCTGCGCTCTGCCCGGCGAGTCGGGCTCTGGAGGAAAAGAAAGTTTGC
CAAGGCACGAGTAACAAGCTCACGCAGTTGGGCACTTTTGAAGATCATTTTCTCAGCCTCCAGAGGATGTTCAATAACTGTGAGGTGGTC
CTTGGGAATTTGGAAATTACCTATGTGCAGAGGAATTATGATCTTTCCTTCTTAAAGACCATCCAGGAGGTGGCTGGTTATGTCCTCATT
GCCCTCAACACAGTGGAGCGAATTCCTTTGGAAAACCTGCAGATCATCAGAGGAAATATGTACTACGAAAATTCCTATGCCTTAGCAGTC
TTATCTAACTATGATGCAAATAAAACCGGACTGAAGGAGCTGCCCATGAGAAATTTACAGGAAATCCTGCATGGCGCCGTGCGGTTCAGC
AACAACCCTGCCCTGTGCAACGTGGAGAGCATCCAGTGGCGGGACATAGTCAGCAGTGACTTTCTCAGCAACATGTCGATGGACTTCCAG
AACCACCTGGGCAGCTGCCAAAAGTGTGATCCAAGCTGTCCCAATGGGAGCTGCTGGGGTGCAGGAGAGGAGAACTGCCAGAAACTGACC
AAAATCATCTGTGCCCAGCAGTGCTCCGGGCGCTGCCGTGGCAAGTCCCCCAGTGACTGCTGCCACAACCAGTGTGCTGCAGGCTGCACA
GGCCCCCGGGAGAGCGACTGCCTGGTCTGCCGCAAATTCCGAGACGAAGCCACGTGCAAGGACACCTGCCCCCCACTCATGCTCTACAAC
CCCACCACGTACCAGATGGATGTGAACCCCGAGGGCAAATACAGCTTTGGTGCCACCTGCGTGAAGAAGTGTCCCCGTAATTATGTGGTG
ACAGATCACGGCTCGTGCGTCCGAGCCTGTGGGGCCGACAGCTATGAGATGGAGGAAGACGGCGTCCGCAAGTGTAAGAAGTGCGAAGGG
CCTTGCCGCAAAGTGTGTAACGGAATAGGTATTGGTGAATTTAAAGACTCACTCTCCATAAATGCTACGAATATTAAACACTTCAAAAAC
TGCACCTCCATCAGTGGCGATCTCCACATCCTGCCGGTGGCATTTAGGGGTGACTCCTTCACACATACTCCTCCTCTGGATCCACAGGAA
CTGGATATTCTGAAAACCGTAAAGGAAATCACAGGGTTTTTGCTGATTCAGGCTTGGCCTGAAAACAGGACGGACCTCCATGCCTTTGAG
AACCTAGAAATCATACGCGGCAGGACCAAGCAACATGGTCAGTTTTCTCTTGCAGTCGTCAGCCTGAACATAACATCCTTGGGATTACGC
TCCCTCAAGGAGATAAGTGATGGAGATGTGATAATTTCAGGAAACAAAAATTTGTGCTATGCAAATACAATAAACTGGAAAAAACTGTTT
GGGACCTCCGGTCAGAAAACCAAAATTATAAGCAACAGAGGTGAAAACAGCTGCAAGGCCACAGGCCAGGTCTGCCATGCCTTGTGCTCC
CCCGAGGGCTGCTGGGGCCCGGAGCCCAGGGACTGCGTCTCTTGCCGGAATGTCAGCCGAGGCAGGGAATGCGTGGACAAGTGCAACCTT
CTGGAGGGTGAGCCAAGGGAGTTTGTGGAGAACTCTGAGTGCATACAGTGCCACCCAGAGTGCCTGCCTCAGGCCATGAACATCACCTGC
ACAGGACGGGGACCAGACAACTGTATCCAGTGTGCCCACTACATTGACGGCCCCCACTGCGTCAAGACCTGCCCGGCAGGAGTCATGGGA
GAAAACAACACCCTGGTCTGGAAGTACGCAGACGCCGGCCATGTGTGCCACCTGTGCCATCCAAACTGCACCTACGGATGCACTGGGCCA
GGTCTTGAAGGCTGTCCAACGAATGGGCCTAAGATCCCGTCCATCGCCACTGGGATGGTGGGGGCCCTCCTCTTGCTGCTGGTGGTGGCC
CTGGGGATCGGCCTCTTCATGCGAAGGCGCCACATCGTTCGGAAGCGCACGCTGCGGAGGCTGCTGCAGGAGAGGGAGCTTGTGGAGCCT
CTTACACCCAGTGGAGAAGCTCCCAACCAAGCTCTCTTGAGGATCTTGAAGGAAACTGAATTCAAAAAGATCAAAGTGCTGGGCTCCGGT
GCGTTCGGCACGGTGTATAAGGGACTCTGGATCCCAGAAGGTGAGAAAGTTAAAATTCCCGTCGCTATCAAGGAATTAAGAGAAGCAACA
TCTCCGAAAGCCAACAAGGAAATCCTCGATGAAGCCTACGTGATGGCCAGCGTGGACAACCCCCACGTGTGCCGCCTGCTGGGCATCTGC
CTCACCTCCACCGTGCAGCTCATCACGCAGCTCATGCCCTTCGGCTGCCTCCTGGACTATGTCCGGGAACACAAAGACAATATTGGCTCC
CAGTACCTGCTCAACTGGTGTGTGCAGATCGCAAAGGGCATGAACTACTTGGAGGACCGTCGCTTGGTGCACCGCGACCTGGCAGCCAGG
AACGTACTGGTGAAAACACCGCAGCATGTCAAGATCACAGATTTTGGGCTGGCCAAACTGCTGGGTGCGGAAGAGAAAGAATACCATGCA
GAAGGAGGCAAAGTGCCTATCAAGTGGATGGCATTGGAATCAATTTTACACAGAATCTATACCCACCAGAGTGATGTCTGGAGCTACGGG
GTGACTGTTTGGGAGTTGATGACCTTTGGATCCAAGCCATATGACGGAATCCCTGCCAGCGAGATCTCCTCCATCCTGGAGAAAGGAGAA
CGCCTCCCTCAGCCACCCATATGTACCATCGATGTCTACATGATCATGGTCAAGTGCTGGATGATAGACGCAGATAGTCGCCCAAAGTTC
CGTGAGTTGATCATCGAATTCTCCAAAATGGCCCGAGACCCCCAGCGCTACCTTGTCATTCAGTGCACAGAAGCCAAAAAGCATTGCTGG
TATTTCGAAGGACTCTATCCAACCTATTATATATGCCGCTCCTACGAGGACTGCTGTGGCTCCAGGTGCTGTGTGCGGGCCCTCTCCATA
CAGAGGCTGTGGTACTTCTGGTTCCTTCTGATGATGGGCGTGCTTTTCTGCTGCGGAGCCGGCTTCTTCATCCGGAGGCGCATGTACCCC
CCGCCGCTGATCGAGGAGCCAGCCTTCAATGTGTCCTACACCAGGCAGCCCCCAAATCCCGGCCCAGGAGCCCAGCAGCCGGGGCCGCCC
TATTACACCGACCCAGGAGGACCGGGGATGAACCCTGTCGGGAATTCCATGGCAATGGCTTTCCAGGTCCCACCCAACTCACCCCAGGGG
AGTGTGGCCTGCCCGCCCCCTCCAGCCTACTGCAACACGCCTCCGCCCCCGTACGAACAGGTAGTGAAGGCCAAGTAGTGGGGTGCCCAC
GTGCAAGAGGAGAGACAGGAGAGGGCCTTTCCCTGGCCTTTCTGTCTTCGTTGATGTTCACTTCCAGGAACGGTCTCGTGGGCTGCTAAG
GGCAGTTCCTCTGATATCCTCACAGCAAGCACAGCTCTCTTTCAGGCTTTCCATGGAGTACAATATATGAACTCACACTTTGTCTCCTCT
GTTGCTTCTGTTTCTGACGCAGTCTGTGCTCTCACATGGTAGTGTGGTGACAGTCCCCGAGGGCTGACGTCCTTACGGTGGCGTGACCAG
ATCTACAGGAGAGAGACTGAGAGGAAGAAGGCAGTGCTGGAGGTGCAGGTGGCATGTAGAGGGGCCAGGCCGAGCATCCCAGGCAAGCAT
CCTTCTGCCCGGGTATTAATAGGAAGCCCCATGCCGGGCGGCTCAGCCGATGAAGCAGCAGCCGACTGAGCTGAGCCCAGCAGGTCATCT
GCTCCAGCCTGTCCTCTCGTCAGCCTTCCTCTTCCAGAAGCTGTTGGAGAGACATTCAGGAGAGAGCAAGCCCCTTGTCATGTTTCTGTC
TCTGTTCATATCCTAAAGATAGACTTCTCCTGCACCGCCAGGGAAGGGTAGCACGTGCAGCTCTCACCGCAGGATGGGGCCTAGAATCAG
GCTTGCCTTGGAGGCCTGACAGTGATCTGACATCCACTAAGCAAATTTATTTAAATTCATGGGAAATCACTTCCTGCCCCAAACTGAGAC
ATTGCATTTTGTGAGCTCTTGGTCTGATTTGGAGAAAGGACTGTTACCCATTTTTTTGGTGTGTTTATGGAAGTGCATGTAGAGCGTCCT
GCCCTTTGAAATCAGACTGGGTGTGTGTCTTCCCTGGACATCACTGCCTCTCCAGGGCATTCTCAGGCCCGGGGGTCTCCTTCCCTCAGG
CAGCTCCAGTGGTGGGTTCTGAAGGGTGCTTTCAAAACGGGGCACATCTGGCTGGGAAGTCACATGGACTCTTCCAGGGAGAGAGACCAG
CTGAGGCGTCTCTCTCTGAGGTTGTGTTGGGTCTAAGCGGGTGTGTGCTGGGCTCCAAGGAGGAGGAGCTTGCTGGGAAAAGACAGGAGA
AGTACTGACTCAACTGCACTGACCATGTTGTCATAATTAGAATAAAGAAGAAGTGGTCGGAAATGCACATTCCTGGATAGGAATCACAGC
TCACCCCAGGATCTCACAGGTAGTCTCCTGAGTAGTTGACGGCTAGCGGGGAGCTAGTTCCGCCGCATAGTTATAGTGTTGATGTGTGAA
CGCTGACCTGTCCTGTGTGCTAAGAGCTATGCAGCTTAGCTGAGGCGCCTAGATTACTAGATGTGCTGTATCACGGGGAATGAGGTGGGG
GTGCTTATTTTTTAATGAACTAATCAGAGCCTCTTGAGAAATTGTTACTCATTGAACTGGAGCATCAAGACATCTCATGGAAGTGGATAC
GGAGTGATTTGGTGTCCATGCTTTTCACTCTGAGGACATTTAATCGGAGAACCTCCTGGGGAATTTTGTGGGAGACACTTGGGAACAAAA
CAGACACCCTGGGAATGCAGTTGCAAGCACAGATGCTGCCACCAGTGTCTCTGACCACCCTGGTGTGACTGCTGACTGCCAGCGTGGTAC
CTCCCATGCTGCAGGCCTCCATCTAAATGAGACAACAAAGCACAATGTTCACTGTTTACAACCAAGACAACTGCGTGGGTCCAAACACTC
CTCTTCCTCCAGGTCATTTGTTTTGCATTTTTAATGTCTTTATTTTTTGTAATGAAAAAGCACACTAAGCTGCCCCTGGAATCGGGTGCA
GCTGAATAGGCACCCAAAAGTCCGTGACTAAATTTCGTTTGTCTTTTTGATAGCAAATTATGTTAAGAGACAGTGATGGCTAGGGCTCAA
CAATTTTGTATTCCCATGTTTGTGTGAGACAGAGTTTGTTTTCCCTTGAACTTGGTTAGAATTGTGCTACTGTGAACGCTGATCCTGCAT
ATGGAAGTCCCACTTCGGTGACATTTCCTGGCCATTCTTGTTTCCATTGTGTGGATGGTGGGTTGTGCCCACTTCCTGGAGTGAGACAGC
TCCTGGTGTGTAGAATTCCCGGAGCGTCCGTGGTTCAGAGTAAACTTGAAGCAGATCTGTGCATGCTTTTCCTCTGCAACAATTGGCTCG

>25487_25487_1_EGFR-VOPP1_EGFR_chr7_55268106_ENST00000275493_VOPP1_chr7_55588823_ENST00000285279_length(amino acids)=1136AA_BP=981
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVL
IALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLY
NPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGL
RSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTG
PGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIG
SQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQCTEAKKHC
WYFEGLYPTYYICRSYEDCCGSRCCVRALSIQRLWYFWFLLMMGVLFCCGAGFFIRRRMYPPPLIEEPAFNVSYTRQPPNPGPGAQQPGP

--------------------------------------------------------------
>25487_25487_2_EGFR-VOPP1_EGFR_chr7_55268106_ENST00000275493_VOPP1_chr7_55588823_ENST00000433959_length(transcript)=5829nt_BP=3123nt
GCCGGAGTCCCGAGCTAGCCCCGGCGGCCGCCGCCGCCCAGACCGGACGACAGGCCACCTCGTCGGCGTCCGCCCGAGTCCCCGCCTCGC
CGCCAACGCCACAACCACCGCGCACGGCCCCCTGACTCCGTCCAGTATTGATCGGGAGAGCCGGAGCGAGCTCTTCGGGGAGCAGCGATG
CGACCCTCCGGGACGGCCGGGGCAGCGCTCCTGGCGCTGCTGGCTGCGCTCTGCCCGGCGAGTCGGGCTCTGGAGGAAAAGAAAGTTTGC
CAAGGCACGAGTAACAAGCTCACGCAGTTGGGCACTTTTGAAGATCATTTTCTCAGCCTCCAGAGGATGTTCAATAACTGTGAGGTGGTC
CTTGGGAATTTGGAAATTACCTATGTGCAGAGGAATTATGATCTTTCCTTCTTAAAGACCATCCAGGAGGTGGCTGGTTATGTCCTCATT
GCCCTCAACACAGTGGAGCGAATTCCTTTGGAAAACCTGCAGATCATCAGAGGAAATATGTACTACGAAAATTCCTATGCCTTAGCAGTC
TTATCTAACTATGATGCAAATAAAACCGGACTGAAGGAGCTGCCCATGAGAAATTTACAGGAAATCCTGCATGGCGCCGTGCGGTTCAGC
AACAACCCTGCCCTGTGCAACGTGGAGAGCATCCAGTGGCGGGACATAGTCAGCAGTGACTTTCTCAGCAACATGTCGATGGACTTCCAG
AACCACCTGGGCAGCTGCCAAAAGTGTGATCCAAGCTGTCCCAATGGGAGCTGCTGGGGTGCAGGAGAGGAGAACTGCCAGAAACTGACC
AAAATCATCTGTGCCCAGCAGTGCTCCGGGCGCTGCCGTGGCAAGTCCCCCAGTGACTGCTGCCACAACCAGTGTGCTGCAGGCTGCACA
GGCCCCCGGGAGAGCGACTGCCTGGTCTGCCGCAAATTCCGAGACGAAGCCACGTGCAAGGACACCTGCCCCCCACTCATGCTCTACAAC
CCCACCACGTACCAGATGGATGTGAACCCCGAGGGCAAATACAGCTTTGGTGCCACCTGCGTGAAGAAGTGTCCCCGTAATTATGTGGTG
ACAGATCACGGCTCGTGCGTCCGAGCCTGTGGGGCCGACAGCTATGAGATGGAGGAAGACGGCGTCCGCAAGTGTAAGAAGTGCGAAGGG
CCTTGCCGCAAAGTGTGTAACGGAATAGGTATTGGTGAATTTAAAGACTCACTCTCCATAAATGCTACGAATATTAAACACTTCAAAAAC
TGCACCTCCATCAGTGGCGATCTCCACATCCTGCCGGTGGCATTTAGGGGTGACTCCTTCACACATACTCCTCCTCTGGATCCACAGGAA
CTGGATATTCTGAAAACCGTAAAGGAAATCACAGGGTTTTTGCTGATTCAGGCTTGGCCTGAAAACAGGACGGACCTCCATGCCTTTGAG
AACCTAGAAATCATACGCGGCAGGACCAAGCAACATGGTCAGTTTTCTCTTGCAGTCGTCAGCCTGAACATAACATCCTTGGGATTACGC
TCCCTCAAGGAGATAAGTGATGGAGATGTGATAATTTCAGGAAACAAAAATTTGTGCTATGCAAATACAATAAACTGGAAAAAACTGTTT
GGGACCTCCGGTCAGAAAACCAAAATTATAAGCAACAGAGGTGAAAACAGCTGCAAGGCCACAGGCCAGGTCTGCCATGCCTTGTGCTCC
CCCGAGGGCTGCTGGGGCCCGGAGCCCAGGGACTGCGTCTCTTGCCGGAATGTCAGCCGAGGCAGGGAATGCGTGGACAAGTGCAACCTT
CTGGAGGGTGAGCCAAGGGAGTTTGTGGAGAACTCTGAGTGCATACAGTGCCACCCAGAGTGCCTGCCTCAGGCCATGAACATCACCTGC
ACAGGACGGGGACCAGACAACTGTATCCAGTGTGCCCACTACATTGACGGCCCCCACTGCGTCAAGACCTGCCCGGCAGGAGTCATGGGA
GAAAACAACACCCTGGTCTGGAAGTACGCAGACGCCGGCCATGTGTGCCACCTGTGCCATCCAAACTGCACCTACGGATGCACTGGGCCA
GGTCTTGAAGGCTGTCCAACGAATGGGCCTAAGATCCCGTCCATCGCCACTGGGATGGTGGGGGCCCTCCTCTTGCTGCTGGTGGTGGCC
CTGGGGATCGGCCTCTTCATGCGAAGGCGCCACATCGTTCGGAAGCGCACGCTGCGGAGGCTGCTGCAGGAGAGGGAGCTTGTGGAGCCT
CTTACACCCAGTGGAGAAGCTCCCAACCAAGCTCTCTTGAGGATCTTGAAGGAAACTGAATTCAAAAAGATCAAAGTGCTGGGCTCCGGT
GCGTTCGGCACGGTGTATAAGGGACTCTGGATCCCAGAAGGTGAGAAAGTTAAAATTCCCGTCGCTATCAAGGAATTAAGAGAAGCAACA
TCTCCGAAAGCCAACAAGGAAATCCTCGATGAAGCCTACGTGATGGCCAGCGTGGACAACCCCCACGTGTGCCGCCTGCTGGGCATCTGC
CTCACCTCCACCGTGCAGCTCATCACGCAGCTCATGCCCTTCGGCTGCCTCCTGGACTATGTCCGGGAACACAAAGACAATATTGGCTCC
CAGTACCTGCTCAACTGGTGTGTGCAGATCGCAAAGGGCATGAACTACTTGGAGGACCGTCGCTTGGTGCACCGCGACCTGGCAGCCAGG
AACGTACTGGTGAAAACACCGCAGCATGTCAAGATCACAGATTTTGGGCTGGCCAAACTGCTGGGTGCGGAAGAGAAAGAATACCATGCA
GAAGGAGGCAAAGTGCCTATCAAGTGGATGGCATTGGAATCAATTTTACACAGAATCTATACCCACCAGAGTGATGTCTGGAGCTACGGG
GTGACTGTTTGGGAGTTGATGACCTTTGGATCCAAGCCATATGACGGAATCCCTGCCAGCGAGATCTCCTCCATCCTGGAGAAAGGAGAA
CGCCTCCCTCAGCCACCCATATGTACCATCGATGTCTACATGATCATGGTCAAGTGCTGGATGATAGACGCAGATAGTCGCCCAAAGTTC
CGTGAGTTGATCATCGAATTCTCCAAAATGGCCCGAGACCCCCAGCGCTACCTTGTCATTCAGTGCACAGAAGCCAAAAAGCATTGCTGG
TATTTCGAAGGACTCTATCCAACCTATTATATATGCCGCTCCTACGAGGACTGCTGTGGCTCCAGGTGCTGTGTGCGGGCCCTCTCCATA
CAGAGGCTGTGGTACTTCTGGTTCCTTCTGATGATGGGCGTGCTTTTCTGCTGCGGAGCCGGCTTCTTCATCCGGAGGCGCATGTACCCC
CCGCCGCTGATCGAGGAGCCAGCCTTCAATGTGTCCTACACCAGGCAGCCCCCAAATCCCGGCCCAGGAGCCCAGCAGCCGGGGCCGCCC
TATTACACCGACCCAGGAGGACCGGGGATGAACCCTGTCGGGAATTCCATGGCAATGGCTTTCCAGGTCCCACCCAACTCACCCCAGGGG
AGTGTGGCCTGCCCGCCCCCTCCAGCCTACTGCAACACGCCTCCGCCCCCGTACGAACAGGTAGTGAAGGCCAAGTAGTGGGGTGCCCAC
GTGCAAGAGGAGAGACAGGAGAGGGCCTTTCCCTGGCCTTTCTGTCTTCGTTGATGTTCACTTCCAGGAACGGTCTCGTGGGCTGCTAAG
GGCAGTTCCTCTGATATCCTCACAGCAAGCACAGCTCTCTTTCAGGCTTTCCATGGAGTACAATATATGAACTCACACTTTGTCTCCTCT
GTTGCTTCTGTTTCTGACGCAGTCTGTGCTCTCACATGGTAGTGTGGTGACAGTCCCCGAGGGCTGACGTCCTTACGGTGGCGTGACCAG
ATCTACAGGAGAGAGACTGAGAGGAAGAAGGCAGTGCTGGAGGTGCAGGTGGCATGTAGAGGGGCCAGGCCGAGCATCCCAGGCAAGCAT
CCTTCTGCCCGGGTATTAATAGGAAGCCCCATGCCGGGCGGCTCAGCCGATGAAGCAGCAGCCGACTGAGCTGAGCCCAGCAGGTCATCT
GCTCCAGCCTGTCCTCTCGTCAGCCTTCCTCTTCCAGAAGCTGTTGGAGAGACATTCAGGAGAGAGCAAGCCCCTTGTCATGTTTCTGTC
TCTGTTCATATCCTAAAGATAGACTTCTCCTGCACCGCCAGGGAAGGGTAGCACGTGCAGCTCTCACCGCAGGATGGGGCCTAGAATCAG
GCTTGCCTTGGAGGCCTGACAGTGATCTGACATCCACTAAGCAAATTTATTTAAATTCATGGGAAATCACTTCCTGCCCCAAACTGAGAC
ATTGCATTTTGTGAGCTCTTGGTCTGATTTGGAGAAAGGACTGTTACCCATTTTTTTGGTGTGTTTATGGAAGTGCATGTAGAGCGTCCT
GCCCTTTGAAATCAGACTGGGTGTGTGTCTTCCCTGGACATCACTGCCTCTCCAGGGCATTCTCAGGCCCGGGGGTCTCCTTCCCTCAGG
CAGCTCCAGTGGTGGGTTCTGAAGGGTGCTTTCAAAACGGGGCACATCTGGCTGGGAAGTCACATGGACTCTTCCAGGGAGAGAGACCAG
CTGAGGCGTCTCTCTCTGAGGTTGTGTTGGGTCTAAGCGGGTGTGTGCTGGGCTCCAAGGAGGAGGAGCTTGCTGGGAAAAGACAGGAGA
AGTACTGACTCAACTGCACTGACCATGTTGTCATAATTAGAATAAAGAAGAAGTGGTCGGAAATGCACATTCCTGGATAGGAATCACAGC
TCACCCCAGGATCTCACAGGTAGTCTCCTGAGTAGTTGACGGCTAGCGGGGAGCTAGTTCCGCCGCATAGTTATAGTGTTGATGTGTGAA
CGCTGACCTGTCCTGTGTGCTAAGAGCTATGCAGCTTAGCTGAGGCGCCTAGATTACTAGATGTGCTGTATCACGGGGAATGAGGTGGGG
GTGCTTATTTTTTAATGAACTAATCAGAGCCTCTTGAGAAATTGTTACTCATTGAACTGGAGCATCAAGACATCTCATGGAAGTGGATAC
GGAGTGATTTGGTGTCCATGCTTTTCACTCTGAGGACATTTAATCGGAGAACCTCCTGGGGAATTTTGTGGGAGACACTTGGGAACAAAA
CAGACACCCTGGGAATGCAGTTGCAAGCACAGATGCTGCCACCAGTGTCTCTGACCACCCTGGTGTGACTGCTGACTGCCAGCGTGGTAC
CTCCCATGCTGCAGGCCTCCATCTAAATGAGACAACAAAGCACAATGTTCACTGTTTACAACCAAGACAACTGCGTGGGTCCAAACACTC
CTCTTCCTCCAGGTCATTTGTTTTGCATTTTTAATGTCTTTATTTTTTGTAATGAAAAAGCACACTAAGCTGCCCCTGGAATCGGGTGCA
GCTGAATAGGCACCCAAAAGTCCGTGACTAAATTTCGTTTGTCTTTTTGATAGCAAATTATGTTAAGAGACAGTGATGGCTAGGGCTCAA
CAATTTTGTATTCCCATGTTTGTGTGAGACAGAGTTTGTTTTCCCTTGAACTTGGTTAGAATTGTGCTACTGTGAACGCTGATCCTGCAT
ATGGAAGTCCCACTTCGGTGACATTTCCTGGCCATTCTTGTTTCCATTGTGTGGATGGTGGGTTGTGCCCACTTCCTGGAGTGAGACAGC
TCCTGGTGTGTAGAATTCCCGGAGCGTCCGTGGTTCAGAGTAAACTTGAAGCAGATCTGTGCATGCTTTTCCTCTGCAACAATTGGCTCG

>25487_25487_2_EGFR-VOPP1_EGFR_chr7_55268106_ENST00000275493_VOPP1_chr7_55588823_ENST00000433959_length(amino acids)=1136AA_BP=981
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVL
IALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLY
NPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGL
RSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTG
PGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIG
SQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQCTEAKKHC
WYFEGLYPTYYICRSYEDCCGSRCCVRALSIQRLWYFWFLLMMGVLFCCGAGFFIRRRMYPPPLIEEPAFNVSYTRQPPNPGPGAQQPGP

--------------------------------------------------------------
>25487_25487_3_EGFR-VOPP1_EGFR_chr7_55268106_ENST00000275493_VOPP1_chr7_55588823_ENST00000545390_length(transcript)=5829nt_BP=3123nt
GCCGGAGTCCCGAGCTAGCCCCGGCGGCCGCCGCCGCCCAGACCGGACGACAGGCCACCTCGTCGGCGTCCGCCCGAGTCCCCGCCTCGC
CGCCAACGCCACAACCACCGCGCACGGCCCCCTGACTCCGTCCAGTATTGATCGGGAGAGCCGGAGCGAGCTCTTCGGGGAGCAGCGATG
CGACCCTCCGGGACGGCCGGGGCAGCGCTCCTGGCGCTGCTGGCTGCGCTCTGCCCGGCGAGTCGGGCTCTGGAGGAAAAGAAAGTTTGC
CAAGGCACGAGTAACAAGCTCACGCAGTTGGGCACTTTTGAAGATCATTTTCTCAGCCTCCAGAGGATGTTCAATAACTGTGAGGTGGTC
CTTGGGAATTTGGAAATTACCTATGTGCAGAGGAATTATGATCTTTCCTTCTTAAAGACCATCCAGGAGGTGGCTGGTTATGTCCTCATT
GCCCTCAACACAGTGGAGCGAATTCCTTTGGAAAACCTGCAGATCATCAGAGGAAATATGTACTACGAAAATTCCTATGCCTTAGCAGTC
TTATCTAACTATGATGCAAATAAAACCGGACTGAAGGAGCTGCCCATGAGAAATTTACAGGAAATCCTGCATGGCGCCGTGCGGTTCAGC
AACAACCCTGCCCTGTGCAACGTGGAGAGCATCCAGTGGCGGGACATAGTCAGCAGTGACTTTCTCAGCAACATGTCGATGGACTTCCAG
AACCACCTGGGCAGCTGCCAAAAGTGTGATCCAAGCTGTCCCAATGGGAGCTGCTGGGGTGCAGGAGAGGAGAACTGCCAGAAACTGACC
AAAATCATCTGTGCCCAGCAGTGCTCCGGGCGCTGCCGTGGCAAGTCCCCCAGTGACTGCTGCCACAACCAGTGTGCTGCAGGCTGCACA
GGCCCCCGGGAGAGCGACTGCCTGGTCTGCCGCAAATTCCGAGACGAAGCCACGTGCAAGGACACCTGCCCCCCACTCATGCTCTACAAC
CCCACCACGTACCAGATGGATGTGAACCCCGAGGGCAAATACAGCTTTGGTGCCACCTGCGTGAAGAAGTGTCCCCGTAATTATGTGGTG
ACAGATCACGGCTCGTGCGTCCGAGCCTGTGGGGCCGACAGCTATGAGATGGAGGAAGACGGCGTCCGCAAGTGTAAGAAGTGCGAAGGG
CCTTGCCGCAAAGTGTGTAACGGAATAGGTATTGGTGAATTTAAAGACTCACTCTCCATAAATGCTACGAATATTAAACACTTCAAAAAC
TGCACCTCCATCAGTGGCGATCTCCACATCCTGCCGGTGGCATTTAGGGGTGACTCCTTCACACATACTCCTCCTCTGGATCCACAGGAA
CTGGATATTCTGAAAACCGTAAAGGAAATCACAGGGTTTTTGCTGATTCAGGCTTGGCCTGAAAACAGGACGGACCTCCATGCCTTTGAG
AACCTAGAAATCATACGCGGCAGGACCAAGCAACATGGTCAGTTTTCTCTTGCAGTCGTCAGCCTGAACATAACATCCTTGGGATTACGC
TCCCTCAAGGAGATAAGTGATGGAGATGTGATAATTTCAGGAAACAAAAATTTGTGCTATGCAAATACAATAAACTGGAAAAAACTGTTT
GGGACCTCCGGTCAGAAAACCAAAATTATAAGCAACAGAGGTGAAAACAGCTGCAAGGCCACAGGCCAGGTCTGCCATGCCTTGTGCTCC
CCCGAGGGCTGCTGGGGCCCGGAGCCCAGGGACTGCGTCTCTTGCCGGAATGTCAGCCGAGGCAGGGAATGCGTGGACAAGTGCAACCTT
CTGGAGGGTGAGCCAAGGGAGTTTGTGGAGAACTCTGAGTGCATACAGTGCCACCCAGAGTGCCTGCCTCAGGCCATGAACATCACCTGC
ACAGGACGGGGACCAGACAACTGTATCCAGTGTGCCCACTACATTGACGGCCCCCACTGCGTCAAGACCTGCCCGGCAGGAGTCATGGGA
GAAAACAACACCCTGGTCTGGAAGTACGCAGACGCCGGCCATGTGTGCCACCTGTGCCATCCAAACTGCACCTACGGATGCACTGGGCCA
GGTCTTGAAGGCTGTCCAACGAATGGGCCTAAGATCCCGTCCATCGCCACTGGGATGGTGGGGGCCCTCCTCTTGCTGCTGGTGGTGGCC
CTGGGGATCGGCCTCTTCATGCGAAGGCGCCACATCGTTCGGAAGCGCACGCTGCGGAGGCTGCTGCAGGAGAGGGAGCTTGTGGAGCCT
CTTACACCCAGTGGAGAAGCTCCCAACCAAGCTCTCTTGAGGATCTTGAAGGAAACTGAATTCAAAAAGATCAAAGTGCTGGGCTCCGGT
GCGTTCGGCACGGTGTATAAGGGACTCTGGATCCCAGAAGGTGAGAAAGTTAAAATTCCCGTCGCTATCAAGGAATTAAGAGAAGCAACA
TCTCCGAAAGCCAACAAGGAAATCCTCGATGAAGCCTACGTGATGGCCAGCGTGGACAACCCCCACGTGTGCCGCCTGCTGGGCATCTGC
CTCACCTCCACCGTGCAGCTCATCACGCAGCTCATGCCCTTCGGCTGCCTCCTGGACTATGTCCGGGAACACAAAGACAATATTGGCTCC
CAGTACCTGCTCAACTGGTGTGTGCAGATCGCAAAGGGCATGAACTACTTGGAGGACCGTCGCTTGGTGCACCGCGACCTGGCAGCCAGG
AACGTACTGGTGAAAACACCGCAGCATGTCAAGATCACAGATTTTGGGCTGGCCAAACTGCTGGGTGCGGAAGAGAAAGAATACCATGCA
GAAGGAGGCAAAGTGCCTATCAAGTGGATGGCATTGGAATCAATTTTACACAGAATCTATACCCACCAGAGTGATGTCTGGAGCTACGGG
GTGACTGTTTGGGAGTTGATGACCTTTGGATCCAAGCCATATGACGGAATCCCTGCCAGCGAGATCTCCTCCATCCTGGAGAAAGGAGAA
CGCCTCCCTCAGCCACCCATATGTACCATCGATGTCTACATGATCATGGTCAAGTGCTGGATGATAGACGCAGATAGTCGCCCAAAGTTC
CGTGAGTTGATCATCGAATTCTCCAAAATGGCCCGAGACCCCCAGCGCTACCTTGTCATTCAGTGCACAGAAGCCAAAAAGCATTGCTGG
TATTTCGAAGGACTCTATCCAACCTATTATATATGCCGCTCCTACGAGGACTGCTGTGGCTCCAGGTGCTGTGTGCGGGCCCTCTCCATA
CAGAGGCTGTGGTACTTCTGGTTCCTTCTGATGATGGGCGTGCTTTTCTGCTGCGGAGCCGGCTTCTTCATCCGGAGGCGCATGTACCCC
CCGCCGCTGATCGAGGAGCCAGCCTTCAATGTGTCCTACACCAGGCAGCCCCCAAATCCCGGCCCAGGAGCCCAGCAGCCGGGGCCGCCC
TATTACACCGACCCAGGAGGACCGGGGATGAACCCTGTCGGGAATTCCATGGCAATGGCTTTCCAGGTCCCACCCAACTCACCCCAGGGG
AGTGTGGCCTGCCCGCCCCCTCCAGCCTACTGCAACACGCCTCCGCCCCCGTACGAACAGGTAGTGAAGGCCAAGTAGTGGGGTGCCCAC
GTGCAAGAGGAGAGACAGGAGAGGGCCTTTCCCTGGCCTTTCTGTCTTCGTTGATGTTCACTTCCAGGAACGGTCTCGTGGGCTGCTAAG
GGCAGTTCCTCTGATATCCTCACAGCAAGCACAGCTCTCTTTCAGGCTTTCCATGGAGTACAATATATGAACTCACACTTTGTCTCCTCT
GTTGCTTCTGTTTCTGACGCAGTCTGTGCTCTCACATGGTAGTGTGGTGACAGTCCCCGAGGGCTGACGTCCTTACGGTGGCGTGACCAG
ATCTACAGGAGAGAGACTGAGAGGAAGAAGGCAGTGCTGGAGGTGCAGGTGGCATGTAGAGGGGCCAGGCCGAGCATCCCAGGCAAGCAT
CCTTCTGCCCGGGTATTAATAGGAAGCCCCATGCCGGGCGGCTCAGCCGATGAAGCAGCAGCCGACTGAGCTGAGCCCAGCAGGTCATCT
GCTCCAGCCTGTCCTCTCGTCAGCCTTCCTCTTCCAGAAGCTGTTGGAGAGACATTCAGGAGAGAGCAAGCCCCTTGTCATGTTTCTGTC
TCTGTTCATATCCTAAAGATAGACTTCTCCTGCACCGCCAGGGAAGGGTAGCACGTGCAGCTCTCACCGCAGGATGGGGCCTAGAATCAG
GCTTGCCTTGGAGGCCTGACAGTGATCTGACATCCACTAAGCAAATTTATTTAAATTCATGGGAAATCACTTCCTGCCCCAAACTGAGAC
ATTGCATTTTGTGAGCTCTTGGTCTGATTTGGAGAAAGGACTGTTACCCATTTTTTTGGTGTGTTTATGGAAGTGCATGTAGAGCGTCCT
GCCCTTTGAAATCAGACTGGGTGTGTGTCTTCCCTGGACATCACTGCCTCTCCAGGGCATTCTCAGGCCCGGGGGTCTCCTTCCCTCAGG
CAGCTCCAGTGGTGGGTTCTGAAGGGTGCTTTCAAAACGGGGCACATCTGGCTGGGAAGTCACATGGACTCTTCCAGGGAGAGAGACCAG
CTGAGGCGTCTCTCTCTGAGGTTGTGTTGGGTCTAAGCGGGTGTGTGCTGGGCTCCAAGGAGGAGGAGCTTGCTGGGAAAAGACAGGAGA
AGTACTGACTCAACTGCACTGACCATGTTGTCATAATTAGAATAAAGAAGAAGTGGTCGGAAATGCACATTCCTGGATAGGAATCACAGC
TCACCCCAGGATCTCACAGGTAGTCTCCTGAGTAGTTGACGGCTAGCGGGGAGCTAGTTCCGCCGCATAGTTATAGTGTTGATGTGTGAA
CGCTGACCTGTCCTGTGTGCTAAGAGCTATGCAGCTTAGCTGAGGCGCCTAGATTACTAGATGTGCTGTATCACGGGGAATGAGGTGGGG
GTGCTTATTTTTTAATGAACTAATCAGAGCCTCTTGAGAAATTGTTACTCATTGAACTGGAGCATCAAGACATCTCATGGAAGTGGATAC
GGAGTGATTTGGTGTCCATGCTTTTCACTCTGAGGACATTTAATCGGAGAACCTCCTGGGGAATTTTGTGGGAGACACTTGGGAACAAAA
CAGACACCCTGGGAATGCAGTTGCAAGCACAGATGCTGCCACCAGTGTCTCTGACCACCCTGGTGTGACTGCTGACTGCCAGCGTGGTAC
CTCCCATGCTGCAGGCCTCCATCTAAATGAGACAACAAAGCACAATGTTCACTGTTTACAACCAAGACAACTGCGTGGGTCCAAACACTC
CTCTTCCTCCAGGTCATTTGTTTTGCATTTTTAATGTCTTTATTTTTTGTAATGAAAAAGCACACTAAGCTGCCCCTGGAATCGGGTGCA
GCTGAATAGGCACCCAAAAGTCCGTGACTAAATTTCGTTTGTCTTTTTGATAGCAAATTATGTTAAGAGACAGTGATGGCTAGGGCTCAA
CAATTTTGTATTCCCATGTTTGTGTGAGACAGAGTTTGTTTTCCCTTGAACTTGGTTAGAATTGTGCTACTGTGAACGCTGATCCTGCAT
ATGGAAGTCCCACTTCGGTGACATTTCCTGGCCATTCTTGTTTCCATTGTGTGGATGGTGGGTTGTGCCCACTTCCTGGAGTGAGACAGC
TCCTGGTGTGTAGAATTCCCGGAGCGTCCGTGGTTCAGAGTAAACTTGAAGCAGATCTGTGCATGCTTTTCCTCTGCAACAATTGGCTCG

>25487_25487_3_EGFR-VOPP1_EGFR_chr7_55268106_ENST00000275493_VOPP1_chr7_55588823_ENST00000545390_length(amino acids)=1136AA_BP=981
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVL
IALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLY
NPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGL
RSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTG
PGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIG
SQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQCTEAKKHC
WYFEGLYPTYYICRSYEDCCGSRCCVRALSIQRLWYFWFLLMMGVLFCCGAGFFIRRRMYPPPLIEEPAFNVSYTRQPPNPGPGAQQPGP

--------------------------------------------------------------
>25487_25487_4_EGFR-VOPP1_EGFR_chr7_55268106_ENST00000454757_VOPP1_chr7_55588823_ENST00000285279_length(transcript)=5677nt_BP=2970nt
ACTGGACTTCAGAACAAGAGGGAGCTCTGGGCTGCTGGCTGGTTGTGCATTTGCTGTGGGTTCCCTCCGGCAGGCGACCTCTCCGCGCTG
AGAAGGTTATCCGGATAACCAATTTGCCAAGGCACGAGTAACAAGCTCACGCAGTTGGGCACTTTTGAAGATCATTTTCTCAGCCTCCAG
AGGATGTTCAATAACTGTGAGGTGGTCCTTGGGAATTTGGAAATTACCTATGTGCAGAGGAATTATGATCTTTCCTTCTTAAAGACCATC
CAGGAGGTGGCTGGTTATGTCCTCATTGCCCTCAACACAGTGGAGCGAATTCCTTTGGAAAACCTGCAGATCATCAGAGGAAATATGTAC
TACGAAAATTCCTATGCCTTAGCAGTCTTATCTAACTATGATGCAAATAAAACCGGACTGAAGGAGCTGCCCATGAGAAATTTACAGGAA
ATCCTGCATGGCGCCGTGCGGTTCAGCAACAACCCTGCCCTGTGCAACGTGGAGAGCATCCAGTGGCGGGACATAGTCAGCAGTGACTTT
CTCAGCAACATGTCGATGGACTTCCAGAACCACCTGGGCAGCTGCCAAAAGTGTGATCCAAGCTGTCCCAATGGGAGCTGCTGGGGTGCA
GGAGAGGAGAACTGCCAGAAACTGACCAAAATCATCTGTGCCCAGCAGTGCTCCGGGCGCTGCCGTGGCAAGTCCCCCAGTGACTGCTGC
CACAACCAGTGTGCTGCAGGCTGCACAGGCCCCCGGGAGAGCGACTGCCTGGTCTGCCGCAAATTCCGAGACGAAGCCACGTGCAAGGAC
ACCTGCCCCCCACTCATGCTCTACAACCCCACCACGTACCAGATGGATGTGAACCCCGAGGGCAAATACAGCTTTGGTGCCACCTGCGTG
AAGAAGTGTCCCCGTAATTATGTGGTGACAGATCACGGCTCGTGCGTCCGAGCCTGTGGGGCCGACAGCTATGAGATGGAGGAAGACGGC
GTCCGCAAGTGTAAGAAGTGCGAAGGGCCTTGCCGCAAAGTGTGTAACGGAATAGGTATTGGTGAATTTAAAGACTCACTCTCCATAAAT
GCTACGAATATTAAACACTTCAAAAACTGCACCTCCATCAGTGGCGATCTCCACATCCTGCCGGTGGCATTTAGGGGTGACTCCTTCACA
CATACTCCTCCTCTGGATCCACAGGAACTGGATATTCTGAAAACCGTAAAGGAAATCACAGGGTTTTTGCTGATTCAGGCTTGGCCTGAA
AACAGGACGGACCTCCATGCCTTTGAGAACCTAGAAATCATACGCGGCAGGACCAAGCAACATGGTCAGTTTTCTCTTGCAGTCGTCAGC
CTGAACATAACATCCTTGGGATTACGCTCCCTCAAGGAGATAAGTGATGGAGATGTGATAATTTCAGGAAACAAAAATTTGTGCTATGCA
AATACAATAAACTGGAAAAAACTGTTTGGGACCTCCGGTCAGAAAACCAAAATTATAAGCAACAGAGGTGAAAACAGCTGCAAGGCCACA
GGCCAGGTCTGCCATGCCTTGTGCTCCCCCGAGGGCTGCTGGGGCCCGGAGCCCAGGGACTGCGTCTCTTGCCGGAATGTCAGCCGAGGC
AGGGAATGCGTGGACAAGTGCAACCTTCTGGAGGGTGAGCCAAGGGAGTTTGTGGAGAACTCTGAGTGCATACAGTGCCACCCAGAGTGC
CTGCCTCAGGCCATGAACATCACCTGCACAGGACGGGGACCAGACAACTGTATCCAGTGTGCCCACTACATTGACGGCCCCCACTGCGTC
AAGACCTGCCCGGCAGGAGTCATGGGAGAAAACAACACCCTGGTCTGGAAGTACGCAGACGCCGGCCATGTGTGCCACCTGTGCCATCCA
AACTGCACCTACGGATGCACTGGGCCAGGTCTTGAAGGCTGTCCAACGAATGGGCCTAAGATCCCGTCCATCGCCACTGGGATGGTGGGG
GCCCTCCTCTTGCTGCTGGTGGTGGCCCTGGGGATCGGCCTCTTCATGCGAAGGCGCCACATCGTTCGGAAGCGCACGCTGCGGAGGCTG
CTGCAGGAGAGGGAGCTTGTGGAGCCTCTTACACCCAGTGGAGAAGCTCCCAACCAAGCTCTCTTGAGGATCTTGAAGGAAACTGAATTC
AAAAAGATCAAAGTGCTGGGCTCCGGTGCGTTCGGCACGGTGTATAAGGGACTCTGGATCCCAGAAGGTGAGAAAGTTAAAATTCCCGTC
GCTATCAAGGAATTAAGAGAAGCAACATCTCCGAAAGCCAACAAGGAAATCCTCGATGAAGCCTACGTGATGGCCAGCGTGGACAACCCC
CACGTGTGCCGCCTGCTGGGCATCTGCCTCACCTCCACCGTGCAGCTCATCACGCAGCTCATGCCCTTCGGCTGCCTCCTGGACTATGTC
CGGGAACACAAAGACAATATTGGCTCCCAGTACCTGCTCAACTGGTGTGTGCAGATCGCAAAGGGCATGAACTACTTGGAGGACCGTCGC
TTGGTGCACCGCGACCTGGCAGCCAGGAACGTACTGGTGAAAACACCGCAGCATGTCAAGATCACAGATTTTGGGCTGGCCAAACTGCTG
GGTGCGGAAGAGAAAGAATACCATGCAGAAGGAGGCAAAGTGCCTATCAAGTGGATGGCATTGGAATCAATTTTACACAGAATCTATACC
CACCAGAGTGATGTCTGGAGCTACGGGGTGACTGTTTGGGAGTTGATGACCTTTGGATCCAAGCCATATGACGGAATCCCTGCCAGCGAG
ATCTCCTCCATCCTGGAGAAAGGAGAACGCCTCCCTCAGCCACCCATATGTACCATCGATGTCTACATGATCATGGTCAAGTGCTGGATG
ATAGACGCAGATAGTCGCCCAAAGTTCCGTGAGTTGATCATCGAATTCTCCAAAATGGCCCGAGACCCCCAGCGCTACCTTGTCATTCAG
TGCACAGAAGCCAAAAAGCATTGCTGGTATTTCGAAGGACTCTATCCAACCTATTATATATGCCGCTCCTACGAGGACTGCTGTGGCTCC
AGGTGCTGTGTGCGGGCCCTCTCCATACAGAGGCTGTGGTACTTCTGGTTCCTTCTGATGATGGGCGTGCTTTTCTGCTGCGGAGCCGGC
TTCTTCATCCGGAGGCGCATGTACCCCCCGCCGCTGATCGAGGAGCCAGCCTTCAATGTGTCCTACACCAGGCAGCCCCCAAATCCCGGC
CCAGGAGCCCAGCAGCCGGGGCCGCCCTATTACACCGACCCAGGAGGACCGGGGATGAACCCTGTCGGGAATTCCATGGCAATGGCTTTC
CAGGTCCCACCCAACTCACCCCAGGGGAGTGTGGCCTGCCCGCCCCCTCCAGCCTACTGCAACACGCCTCCGCCCCCGTACGAACAGGTA
GTGAAGGCCAAGTAGTGGGGTGCCCACGTGCAAGAGGAGAGACAGGAGAGGGCCTTTCCCTGGCCTTTCTGTCTTCGTTGATGTTCACTT
CCAGGAACGGTCTCGTGGGCTGCTAAGGGCAGTTCCTCTGATATCCTCACAGCAAGCACAGCTCTCTTTCAGGCTTTCCATGGAGTACAA
TATATGAACTCACACTTTGTCTCCTCTGTTGCTTCTGTTTCTGACGCAGTCTGTGCTCTCACATGGTAGTGTGGTGACAGTCCCCGAGGG
CTGACGTCCTTACGGTGGCGTGACCAGATCTACAGGAGAGAGACTGAGAGGAAGAAGGCAGTGCTGGAGGTGCAGGTGGCATGTAGAGGG
GCCAGGCCGAGCATCCCAGGCAAGCATCCTTCTGCCCGGGTATTAATAGGAAGCCCCATGCCGGGCGGCTCAGCCGATGAAGCAGCAGCC
GACTGAGCTGAGCCCAGCAGGTCATCTGCTCCAGCCTGTCCTCTCGTCAGCCTTCCTCTTCCAGAAGCTGTTGGAGAGACATTCAGGAGA
GAGCAAGCCCCTTGTCATGTTTCTGTCTCTGTTCATATCCTAAAGATAGACTTCTCCTGCACCGCCAGGGAAGGGTAGCACGTGCAGCTC
TCACCGCAGGATGGGGCCTAGAATCAGGCTTGCCTTGGAGGCCTGACAGTGATCTGACATCCACTAAGCAAATTTATTTAAATTCATGGG
AAATCACTTCCTGCCCCAAACTGAGACATTGCATTTTGTGAGCTCTTGGTCTGATTTGGAGAAAGGACTGTTACCCATTTTTTTGGTGTG
TTTATGGAAGTGCATGTAGAGCGTCCTGCCCTTTGAAATCAGACTGGGTGTGTGTCTTCCCTGGACATCACTGCCTCTCCAGGGCATTCT
CAGGCCCGGGGGTCTCCTTCCCTCAGGCAGCTCCAGTGGTGGGTTCTGAAGGGTGCTTTCAAAACGGGGCACATCTGGCTGGGAAGTCAC
ATGGACTCTTCCAGGGAGAGAGACCAGCTGAGGCGTCTCTCTCTGAGGTTGTGTTGGGTCTAAGCGGGTGTGTGCTGGGCTCCAAGGAGG
AGGAGCTTGCTGGGAAAAGACAGGAGAAGTACTGACTCAACTGCACTGACCATGTTGTCATAATTAGAATAAAGAAGAAGTGGTCGGAAA
TGCACATTCCTGGATAGGAATCACAGCTCACCCCAGGATCTCACAGGTAGTCTCCTGAGTAGTTGACGGCTAGCGGGGAGCTAGTTCCGC
CGCATAGTTATAGTGTTGATGTGTGAACGCTGACCTGTCCTGTGTGCTAAGAGCTATGCAGCTTAGCTGAGGCGCCTAGATTACTAGATG
TGCTGTATCACGGGGAATGAGGTGGGGGTGCTTATTTTTTAATGAACTAATCAGAGCCTCTTGAGAAATTGTTACTCATTGAACTGGAGC
ATCAAGACATCTCATGGAAGTGGATACGGAGTGATTTGGTGTCCATGCTTTTCACTCTGAGGACATTTAATCGGAGAACCTCCTGGGGAA
TTTTGTGGGAGACACTTGGGAACAAAACAGACACCCTGGGAATGCAGTTGCAAGCACAGATGCTGCCACCAGTGTCTCTGACCACCCTGG
TGTGACTGCTGACTGCCAGCGTGGTACCTCCCATGCTGCAGGCCTCCATCTAAATGAGACAACAAAGCACAATGTTCACTGTTTACAACC
AAGACAACTGCGTGGGTCCAAACACTCCTCTTCCTCCAGGTCATTTGTTTTGCATTTTTAATGTCTTTATTTTTTGTAATGAAAAAGCAC
ACTAAGCTGCCCCTGGAATCGGGTGCAGCTGAATAGGCACCCAAAAGTCCGTGACTAAATTTCGTTTGTCTTTTTGATAGCAAATTATGT
TAAGAGACAGTGATGGCTAGGGCTCAACAATTTTGTATTCCCATGTTTGTGTGAGACAGAGTTTGTTTTCCCTTGAACTTGGTTAGAATT
GTGCTACTGTGAACGCTGATCCTGCATATGGAAGTCCCACTTCGGTGACATTTCCTGGCCATTCTTGTTTCCATTGTGTGGATGGTGGGT
TGTGCCCACTTCCTGGAGTGAGACAGCTCCTGGTGTGTAGAATTCCCGGAGCGTCCGTGGTTCAGAGTAAACTTGAAGCAGATCTGTGCA
TGCTTTTCCTCTGCAACAATTGGCTCGTTTCTCTTTTTTGTTCTCTTTTGATAGGATCCTGTTTCCTATGTGTGCAAAATAAAAATAAAT

>25487_25487_4_EGFR-VOPP1_EGFR_chr7_55268106_ENST00000454757_VOPP1_chr7_55588823_ENST00000285279_length(amino acids)=1096AA_BP=941
MGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKT
GLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCS
GRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRA
CGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKE
ITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKI
ISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCI
QCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRR
RHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEIL
DEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH
VKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT
IDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQCTEAKKHCWYFEGLYPTYYICRSYEDCCGSRCCVRALSIQRLWYFWFL
LMMGVLFCCGAGFFIRRRMYPPPLIEEPAFNVSYTRQPPNPGPGAQQPGPPYYTDPGGPGMNPVGNSMAMAFQVPPNSPQGSVACPPPPA

--------------------------------------------------------------
>25487_25487_5_EGFR-VOPP1_EGFR_chr7_55268106_ENST00000454757_VOPP1_chr7_55588823_ENST00000433959_length(transcript)=5676nt_BP=2970nt
ACTGGACTTCAGAACAAGAGGGAGCTCTGGGCTGCTGGCTGGTTGTGCATTTGCTGTGGGTTCCCTCCGGCAGGCGACCTCTCCGCGCTG
AGAAGGTTATCCGGATAACCAATTTGCCAAGGCACGAGTAACAAGCTCACGCAGTTGGGCACTTTTGAAGATCATTTTCTCAGCCTCCAG
AGGATGTTCAATAACTGTGAGGTGGTCCTTGGGAATTTGGAAATTACCTATGTGCAGAGGAATTATGATCTTTCCTTCTTAAAGACCATC
CAGGAGGTGGCTGGTTATGTCCTCATTGCCCTCAACACAGTGGAGCGAATTCCTTTGGAAAACCTGCAGATCATCAGAGGAAATATGTAC
TACGAAAATTCCTATGCCTTAGCAGTCTTATCTAACTATGATGCAAATAAAACCGGACTGAAGGAGCTGCCCATGAGAAATTTACAGGAA
ATCCTGCATGGCGCCGTGCGGTTCAGCAACAACCCTGCCCTGTGCAACGTGGAGAGCATCCAGTGGCGGGACATAGTCAGCAGTGACTTT
CTCAGCAACATGTCGATGGACTTCCAGAACCACCTGGGCAGCTGCCAAAAGTGTGATCCAAGCTGTCCCAATGGGAGCTGCTGGGGTGCA
GGAGAGGAGAACTGCCAGAAACTGACCAAAATCATCTGTGCCCAGCAGTGCTCCGGGCGCTGCCGTGGCAAGTCCCCCAGTGACTGCTGC
CACAACCAGTGTGCTGCAGGCTGCACAGGCCCCCGGGAGAGCGACTGCCTGGTCTGCCGCAAATTCCGAGACGAAGCCACGTGCAAGGAC
ACCTGCCCCCCACTCATGCTCTACAACCCCACCACGTACCAGATGGATGTGAACCCCGAGGGCAAATACAGCTTTGGTGCCACCTGCGTG
AAGAAGTGTCCCCGTAATTATGTGGTGACAGATCACGGCTCGTGCGTCCGAGCCTGTGGGGCCGACAGCTATGAGATGGAGGAAGACGGC
GTCCGCAAGTGTAAGAAGTGCGAAGGGCCTTGCCGCAAAGTGTGTAACGGAATAGGTATTGGTGAATTTAAAGACTCACTCTCCATAAAT
GCTACGAATATTAAACACTTCAAAAACTGCACCTCCATCAGTGGCGATCTCCACATCCTGCCGGTGGCATTTAGGGGTGACTCCTTCACA
CATACTCCTCCTCTGGATCCACAGGAACTGGATATTCTGAAAACCGTAAAGGAAATCACAGGGTTTTTGCTGATTCAGGCTTGGCCTGAA
AACAGGACGGACCTCCATGCCTTTGAGAACCTAGAAATCATACGCGGCAGGACCAAGCAACATGGTCAGTTTTCTCTTGCAGTCGTCAGC
CTGAACATAACATCCTTGGGATTACGCTCCCTCAAGGAGATAAGTGATGGAGATGTGATAATTTCAGGAAACAAAAATTTGTGCTATGCA
AATACAATAAACTGGAAAAAACTGTTTGGGACCTCCGGTCAGAAAACCAAAATTATAAGCAACAGAGGTGAAAACAGCTGCAAGGCCACA
GGCCAGGTCTGCCATGCCTTGTGCTCCCCCGAGGGCTGCTGGGGCCCGGAGCCCAGGGACTGCGTCTCTTGCCGGAATGTCAGCCGAGGC
AGGGAATGCGTGGACAAGTGCAACCTTCTGGAGGGTGAGCCAAGGGAGTTTGTGGAGAACTCTGAGTGCATACAGTGCCACCCAGAGTGC
CTGCCTCAGGCCATGAACATCACCTGCACAGGACGGGGACCAGACAACTGTATCCAGTGTGCCCACTACATTGACGGCCCCCACTGCGTC
AAGACCTGCCCGGCAGGAGTCATGGGAGAAAACAACACCCTGGTCTGGAAGTACGCAGACGCCGGCCATGTGTGCCACCTGTGCCATCCA
AACTGCACCTACGGATGCACTGGGCCAGGTCTTGAAGGCTGTCCAACGAATGGGCCTAAGATCCCGTCCATCGCCACTGGGATGGTGGGG
GCCCTCCTCTTGCTGCTGGTGGTGGCCCTGGGGATCGGCCTCTTCATGCGAAGGCGCCACATCGTTCGGAAGCGCACGCTGCGGAGGCTG
CTGCAGGAGAGGGAGCTTGTGGAGCCTCTTACACCCAGTGGAGAAGCTCCCAACCAAGCTCTCTTGAGGATCTTGAAGGAAACTGAATTC
AAAAAGATCAAAGTGCTGGGCTCCGGTGCGTTCGGCACGGTGTATAAGGGACTCTGGATCCCAGAAGGTGAGAAAGTTAAAATTCCCGTC
GCTATCAAGGAATTAAGAGAAGCAACATCTCCGAAAGCCAACAAGGAAATCCTCGATGAAGCCTACGTGATGGCCAGCGTGGACAACCCC
CACGTGTGCCGCCTGCTGGGCATCTGCCTCACCTCCACCGTGCAGCTCATCACGCAGCTCATGCCCTTCGGCTGCCTCCTGGACTATGTC
CGGGAACACAAAGACAATATTGGCTCCCAGTACCTGCTCAACTGGTGTGTGCAGATCGCAAAGGGCATGAACTACTTGGAGGACCGTCGC
TTGGTGCACCGCGACCTGGCAGCCAGGAACGTACTGGTGAAAACACCGCAGCATGTCAAGATCACAGATTTTGGGCTGGCCAAACTGCTG
GGTGCGGAAGAGAAAGAATACCATGCAGAAGGAGGCAAAGTGCCTATCAAGTGGATGGCATTGGAATCAATTTTACACAGAATCTATACC
CACCAGAGTGATGTCTGGAGCTACGGGGTGACTGTTTGGGAGTTGATGACCTTTGGATCCAAGCCATATGACGGAATCCCTGCCAGCGAG
ATCTCCTCCATCCTGGAGAAAGGAGAACGCCTCCCTCAGCCACCCATATGTACCATCGATGTCTACATGATCATGGTCAAGTGCTGGATG
ATAGACGCAGATAGTCGCCCAAAGTTCCGTGAGTTGATCATCGAATTCTCCAAAATGGCCCGAGACCCCCAGCGCTACCTTGTCATTCAG
TGCACAGAAGCCAAAAAGCATTGCTGGTATTTCGAAGGACTCTATCCAACCTATTATATATGCCGCTCCTACGAGGACTGCTGTGGCTCC
AGGTGCTGTGTGCGGGCCCTCTCCATACAGAGGCTGTGGTACTTCTGGTTCCTTCTGATGATGGGCGTGCTTTTCTGCTGCGGAGCCGGC
TTCTTCATCCGGAGGCGCATGTACCCCCCGCCGCTGATCGAGGAGCCAGCCTTCAATGTGTCCTACACCAGGCAGCCCCCAAATCCCGGC
CCAGGAGCCCAGCAGCCGGGGCCGCCCTATTACACCGACCCAGGAGGACCGGGGATGAACCCTGTCGGGAATTCCATGGCAATGGCTTTC
CAGGTCCCACCCAACTCACCCCAGGGGAGTGTGGCCTGCCCGCCCCCTCCAGCCTACTGCAACACGCCTCCGCCCCCGTACGAACAGGTA
GTGAAGGCCAAGTAGTGGGGTGCCCACGTGCAAGAGGAGAGACAGGAGAGGGCCTTTCCCTGGCCTTTCTGTCTTCGTTGATGTTCACTT
CCAGGAACGGTCTCGTGGGCTGCTAAGGGCAGTTCCTCTGATATCCTCACAGCAAGCACAGCTCTCTTTCAGGCTTTCCATGGAGTACAA
TATATGAACTCACACTTTGTCTCCTCTGTTGCTTCTGTTTCTGACGCAGTCTGTGCTCTCACATGGTAGTGTGGTGACAGTCCCCGAGGG
CTGACGTCCTTACGGTGGCGTGACCAGATCTACAGGAGAGAGACTGAGAGGAAGAAGGCAGTGCTGGAGGTGCAGGTGGCATGTAGAGGG
GCCAGGCCGAGCATCCCAGGCAAGCATCCTTCTGCCCGGGTATTAATAGGAAGCCCCATGCCGGGCGGCTCAGCCGATGAAGCAGCAGCC
GACTGAGCTGAGCCCAGCAGGTCATCTGCTCCAGCCTGTCCTCTCGTCAGCCTTCCTCTTCCAGAAGCTGTTGGAGAGACATTCAGGAGA
GAGCAAGCCCCTTGTCATGTTTCTGTCTCTGTTCATATCCTAAAGATAGACTTCTCCTGCACCGCCAGGGAAGGGTAGCACGTGCAGCTC
TCACCGCAGGATGGGGCCTAGAATCAGGCTTGCCTTGGAGGCCTGACAGTGATCTGACATCCACTAAGCAAATTTATTTAAATTCATGGG
AAATCACTTCCTGCCCCAAACTGAGACATTGCATTTTGTGAGCTCTTGGTCTGATTTGGAGAAAGGACTGTTACCCATTTTTTTGGTGTG
TTTATGGAAGTGCATGTAGAGCGTCCTGCCCTTTGAAATCAGACTGGGTGTGTGTCTTCCCTGGACATCACTGCCTCTCCAGGGCATTCT
CAGGCCCGGGGGTCTCCTTCCCTCAGGCAGCTCCAGTGGTGGGTTCTGAAGGGTGCTTTCAAAACGGGGCACATCTGGCTGGGAAGTCAC
ATGGACTCTTCCAGGGAGAGAGACCAGCTGAGGCGTCTCTCTCTGAGGTTGTGTTGGGTCTAAGCGGGTGTGTGCTGGGCTCCAAGGAGG
AGGAGCTTGCTGGGAAAAGACAGGAGAAGTACTGACTCAACTGCACTGACCATGTTGTCATAATTAGAATAAAGAAGAAGTGGTCGGAAA
TGCACATTCCTGGATAGGAATCACAGCTCACCCCAGGATCTCACAGGTAGTCTCCTGAGTAGTTGACGGCTAGCGGGGAGCTAGTTCCGC
CGCATAGTTATAGTGTTGATGTGTGAACGCTGACCTGTCCTGTGTGCTAAGAGCTATGCAGCTTAGCTGAGGCGCCTAGATTACTAGATG
TGCTGTATCACGGGGAATGAGGTGGGGGTGCTTATTTTTTAATGAACTAATCAGAGCCTCTTGAGAAATTGTTACTCATTGAACTGGAGC
ATCAAGACATCTCATGGAAGTGGATACGGAGTGATTTGGTGTCCATGCTTTTCACTCTGAGGACATTTAATCGGAGAACCTCCTGGGGAA
TTTTGTGGGAGACACTTGGGAACAAAACAGACACCCTGGGAATGCAGTTGCAAGCACAGATGCTGCCACCAGTGTCTCTGACCACCCTGG
TGTGACTGCTGACTGCCAGCGTGGTACCTCCCATGCTGCAGGCCTCCATCTAAATGAGACAACAAAGCACAATGTTCACTGTTTACAACC
AAGACAACTGCGTGGGTCCAAACACTCCTCTTCCTCCAGGTCATTTGTTTTGCATTTTTAATGTCTTTATTTTTTGTAATGAAAAAGCAC
ACTAAGCTGCCCCTGGAATCGGGTGCAGCTGAATAGGCACCCAAAAGTCCGTGACTAAATTTCGTTTGTCTTTTTGATAGCAAATTATGT
TAAGAGACAGTGATGGCTAGGGCTCAACAATTTTGTATTCCCATGTTTGTGTGAGACAGAGTTTGTTTTCCCTTGAACTTGGTTAGAATT
GTGCTACTGTGAACGCTGATCCTGCATATGGAAGTCCCACTTCGGTGACATTTCCTGGCCATTCTTGTTTCCATTGTGTGGATGGTGGGT
TGTGCCCACTTCCTGGAGTGAGACAGCTCCTGGTGTGTAGAATTCCCGGAGCGTCCGTGGTTCAGAGTAAACTTGAAGCAGATCTGTGCA
TGCTTTTCCTCTGCAACAATTGGCTCGTTTCTCTTTTTTGTTCTCTTTTGATAGGATCCTGTTTCCTATGTGTGCAAAATAAAAATAAAT

>25487_25487_5_EGFR-VOPP1_EGFR_chr7_55268106_ENST00000454757_VOPP1_chr7_55588823_ENST00000433959_length(amino acids)=1096AA_BP=941
MGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKT
GLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCS
GRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRA
CGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKE
ITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKI
ISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCI
QCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRR
RHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEIL
DEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH
VKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT
IDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQCTEAKKHCWYFEGLYPTYYICRSYEDCCGSRCCVRALSIQRLWYFWFL
LMMGVLFCCGAGFFIRRRMYPPPLIEEPAFNVSYTRQPPNPGPGAQQPGPPYYTDPGGPGMNPVGNSMAMAFQVPPNSPQGSVACPPPPA

--------------------------------------------------------------
>25487_25487_6_EGFR-VOPP1_EGFR_chr7_55268106_ENST00000454757_VOPP1_chr7_55588823_ENST00000545390_length(transcript)=5676nt_BP=2970nt
ACTGGACTTCAGAACAAGAGGGAGCTCTGGGCTGCTGGCTGGTTGTGCATTTGCTGTGGGTTCCCTCCGGCAGGCGACCTCTCCGCGCTG
AGAAGGTTATCCGGATAACCAATTTGCCAAGGCACGAGTAACAAGCTCACGCAGTTGGGCACTTTTGAAGATCATTTTCTCAGCCTCCAG
AGGATGTTCAATAACTGTGAGGTGGTCCTTGGGAATTTGGAAATTACCTATGTGCAGAGGAATTATGATCTTTCCTTCTTAAAGACCATC
CAGGAGGTGGCTGGTTATGTCCTCATTGCCCTCAACACAGTGGAGCGAATTCCTTTGGAAAACCTGCAGATCATCAGAGGAAATATGTAC
TACGAAAATTCCTATGCCTTAGCAGTCTTATCTAACTATGATGCAAATAAAACCGGACTGAAGGAGCTGCCCATGAGAAATTTACAGGAA
ATCCTGCATGGCGCCGTGCGGTTCAGCAACAACCCTGCCCTGTGCAACGTGGAGAGCATCCAGTGGCGGGACATAGTCAGCAGTGACTTT
CTCAGCAACATGTCGATGGACTTCCAGAACCACCTGGGCAGCTGCCAAAAGTGTGATCCAAGCTGTCCCAATGGGAGCTGCTGGGGTGCA
GGAGAGGAGAACTGCCAGAAACTGACCAAAATCATCTGTGCCCAGCAGTGCTCCGGGCGCTGCCGTGGCAAGTCCCCCAGTGACTGCTGC
CACAACCAGTGTGCTGCAGGCTGCACAGGCCCCCGGGAGAGCGACTGCCTGGTCTGCCGCAAATTCCGAGACGAAGCCACGTGCAAGGAC
ACCTGCCCCCCACTCATGCTCTACAACCCCACCACGTACCAGATGGATGTGAACCCCGAGGGCAAATACAGCTTTGGTGCCACCTGCGTG
AAGAAGTGTCCCCGTAATTATGTGGTGACAGATCACGGCTCGTGCGTCCGAGCCTGTGGGGCCGACAGCTATGAGATGGAGGAAGACGGC
GTCCGCAAGTGTAAGAAGTGCGAAGGGCCTTGCCGCAAAGTGTGTAACGGAATAGGTATTGGTGAATTTAAAGACTCACTCTCCATAAAT
GCTACGAATATTAAACACTTCAAAAACTGCACCTCCATCAGTGGCGATCTCCACATCCTGCCGGTGGCATTTAGGGGTGACTCCTTCACA
CATACTCCTCCTCTGGATCCACAGGAACTGGATATTCTGAAAACCGTAAAGGAAATCACAGGGTTTTTGCTGATTCAGGCTTGGCCTGAA
AACAGGACGGACCTCCATGCCTTTGAGAACCTAGAAATCATACGCGGCAGGACCAAGCAACATGGTCAGTTTTCTCTTGCAGTCGTCAGC
CTGAACATAACATCCTTGGGATTACGCTCCCTCAAGGAGATAAGTGATGGAGATGTGATAATTTCAGGAAACAAAAATTTGTGCTATGCA
AATACAATAAACTGGAAAAAACTGTTTGGGACCTCCGGTCAGAAAACCAAAATTATAAGCAACAGAGGTGAAAACAGCTGCAAGGCCACA
GGCCAGGTCTGCCATGCCTTGTGCTCCCCCGAGGGCTGCTGGGGCCCGGAGCCCAGGGACTGCGTCTCTTGCCGGAATGTCAGCCGAGGC
AGGGAATGCGTGGACAAGTGCAACCTTCTGGAGGGTGAGCCAAGGGAGTTTGTGGAGAACTCTGAGTGCATACAGTGCCACCCAGAGTGC
CTGCCTCAGGCCATGAACATCACCTGCACAGGACGGGGACCAGACAACTGTATCCAGTGTGCCCACTACATTGACGGCCCCCACTGCGTC
AAGACCTGCCCGGCAGGAGTCATGGGAGAAAACAACACCCTGGTCTGGAAGTACGCAGACGCCGGCCATGTGTGCCACCTGTGCCATCCA
AACTGCACCTACGGATGCACTGGGCCAGGTCTTGAAGGCTGTCCAACGAATGGGCCTAAGATCCCGTCCATCGCCACTGGGATGGTGGGG
GCCCTCCTCTTGCTGCTGGTGGTGGCCCTGGGGATCGGCCTCTTCATGCGAAGGCGCCACATCGTTCGGAAGCGCACGCTGCGGAGGCTG
CTGCAGGAGAGGGAGCTTGTGGAGCCTCTTACACCCAGTGGAGAAGCTCCCAACCAAGCTCTCTTGAGGATCTTGAAGGAAACTGAATTC
AAAAAGATCAAAGTGCTGGGCTCCGGTGCGTTCGGCACGGTGTATAAGGGACTCTGGATCCCAGAAGGTGAGAAAGTTAAAATTCCCGTC
GCTATCAAGGAATTAAGAGAAGCAACATCTCCGAAAGCCAACAAGGAAATCCTCGATGAAGCCTACGTGATGGCCAGCGTGGACAACCCC
CACGTGTGCCGCCTGCTGGGCATCTGCCTCACCTCCACCGTGCAGCTCATCACGCAGCTCATGCCCTTCGGCTGCCTCCTGGACTATGTC
CGGGAACACAAAGACAATATTGGCTCCCAGTACCTGCTCAACTGGTGTGTGCAGATCGCAAAGGGCATGAACTACTTGGAGGACCGTCGC
TTGGTGCACCGCGACCTGGCAGCCAGGAACGTACTGGTGAAAACACCGCAGCATGTCAAGATCACAGATTTTGGGCTGGCCAAACTGCTG
GGTGCGGAAGAGAAAGAATACCATGCAGAAGGAGGCAAAGTGCCTATCAAGTGGATGGCATTGGAATCAATTTTACACAGAATCTATACC
CACCAGAGTGATGTCTGGAGCTACGGGGTGACTGTTTGGGAGTTGATGACCTTTGGATCCAAGCCATATGACGGAATCCCTGCCAGCGAG
ATCTCCTCCATCCTGGAGAAAGGAGAACGCCTCCCTCAGCCACCCATATGTACCATCGATGTCTACATGATCATGGTCAAGTGCTGGATG
ATAGACGCAGATAGTCGCCCAAAGTTCCGTGAGTTGATCATCGAATTCTCCAAAATGGCCCGAGACCCCCAGCGCTACCTTGTCATTCAG
TGCACAGAAGCCAAAAAGCATTGCTGGTATTTCGAAGGACTCTATCCAACCTATTATATATGCCGCTCCTACGAGGACTGCTGTGGCTCC
AGGTGCTGTGTGCGGGCCCTCTCCATACAGAGGCTGTGGTACTTCTGGTTCCTTCTGATGATGGGCGTGCTTTTCTGCTGCGGAGCCGGC
TTCTTCATCCGGAGGCGCATGTACCCCCCGCCGCTGATCGAGGAGCCAGCCTTCAATGTGTCCTACACCAGGCAGCCCCCAAATCCCGGC
CCAGGAGCCCAGCAGCCGGGGCCGCCCTATTACACCGACCCAGGAGGACCGGGGATGAACCCTGTCGGGAATTCCATGGCAATGGCTTTC
CAGGTCCCACCCAACTCACCCCAGGGGAGTGTGGCCTGCCCGCCCCCTCCAGCCTACTGCAACACGCCTCCGCCCCCGTACGAACAGGTA
GTGAAGGCCAAGTAGTGGGGTGCCCACGTGCAAGAGGAGAGACAGGAGAGGGCCTTTCCCTGGCCTTTCTGTCTTCGTTGATGTTCACTT
CCAGGAACGGTCTCGTGGGCTGCTAAGGGCAGTTCCTCTGATATCCTCACAGCAAGCACAGCTCTCTTTCAGGCTTTCCATGGAGTACAA
TATATGAACTCACACTTTGTCTCCTCTGTTGCTTCTGTTTCTGACGCAGTCTGTGCTCTCACATGGTAGTGTGGTGACAGTCCCCGAGGG
CTGACGTCCTTACGGTGGCGTGACCAGATCTACAGGAGAGAGACTGAGAGGAAGAAGGCAGTGCTGGAGGTGCAGGTGGCATGTAGAGGG
GCCAGGCCGAGCATCCCAGGCAAGCATCCTTCTGCCCGGGTATTAATAGGAAGCCCCATGCCGGGCGGCTCAGCCGATGAAGCAGCAGCC
GACTGAGCTGAGCCCAGCAGGTCATCTGCTCCAGCCTGTCCTCTCGTCAGCCTTCCTCTTCCAGAAGCTGTTGGAGAGACATTCAGGAGA
GAGCAAGCCCCTTGTCATGTTTCTGTCTCTGTTCATATCCTAAAGATAGACTTCTCCTGCACCGCCAGGGAAGGGTAGCACGTGCAGCTC
TCACCGCAGGATGGGGCCTAGAATCAGGCTTGCCTTGGAGGCCTGACAGTGATCTGACATCCACTAAGCAAATTTATTTAAATTCATGGG
AAATCACTTCCTGCCCCAAACTGAGACATTGCATTTTGTGAGCTCTTGGTCTGATTTGGAGAAAGGACTGTTACCCATTTTTTTGGTGTG
TTTATGGAAGTGCATGTAGAGCGTCCTGCCCTTTGAAATCAGACTGGGTGTGTGTCTTCCCTGGACATCACTGCCTCTCCAGGGCATTCT
CAGGCCCGGGGGTCTCCTTCCCTCAGGCAGCTCCAGTGGTGGGTTCTGAAGGGTGCTTTCAAAACGGGGCACATCTGGCTGGGAAGTCAC
ATGGACTCTTCCAGGGAGAGAGACCAGCTGAGGCGTCTCTCTCTGAGGTTGTGTTGGGTCTAAGCGGGTGTGTGCTGGGCTCCAAGGAGG
AGGAGCTTGCTGGGAAAAGACAGGAGAAGTACTGACTCAACTGCACTGACCATGTTGTCATAATTAGAATAAAGAAGAAGTGGTCGGAAA
TGCACATTCCTGGATAGGAATCACAGCTCACCCCAGGATCTCACAGGTAGTCTCCTGAGTAGTTGACGGCTAGCGGGGAGCTAGTTCCGC
CGCATAGTTATAGTGTTGATGTGTGAACGCTGACCTGTCCTGTGTGCTAAGAGCTATGCAGCTTAGCTGAGGCGCCTAGATTACTAGATG
TGCTGTATCACGGGGAATGAGGTGGGGGTGCTTATTTTTTAATGAACTAATCAGAGCCTCTTGAGAAATTGTTACTCATTGAACTGGAGC
ATCAAGACATCTCATGGAAGTGGATACGGAGTGATTTGGTGTCCATGCTTTTCACTCTGAGGACATTTAATCGGAGAACCTCCTGGGGAA
TTTTGTGGGAGACACTTGGGAACAAAACAGACACCCTGGGAATGCAGTTGCAAGCACAGATGCTGCCACCAGTGTCTCTGACCACCCTGG
TGTGACTGCTGACTGCCAGCGTGGTACCTCCCATGCTGCAGGCCTCCATCTAAATGAGACAACAAAGCACAATGTTCACTGTTTACAACC
AAGACAACTGCGTGGGTCCAAACACTCCTCTTCCTCCAGGTCATTTGTTTTGCATTTTTAATGTCTTTATTTTTTGTAATGAAAAAGCAC
ACTAAGCTGCCCCTGGAATCGGGTGCAGCTGAATAGGCACCCAAAAGTCCGTGACTAAATTTCGTTTGTCTTTTTGATAGCAAATTATGT
TAAGAGACAGTGATGGCTAGGGCTCAACAATTTTGTATTCCCATGTTTGTGTGAGACAGAGTTTGTTTTCCCTTGAACTTGGTTAGAATT
GTGCTACTGTGAACGCTGATCCTGCATATGGAAGTCCCACTTCGGTGACATTTCCTGGCCATTCTTGTTTCCATTGTGTGGATGGTGGGT
TGTGCCCACTTCCTGGAGTGAGACAGCTCCTGGTGTGTAGAATTCCCGGAGCGTCCGTGGTTCAGAGTAAACTTGAAGCAGATCTGTGCA
TGCTTTTCCTCTGCAACAATTGGCTCGTTTCTCTTTTTTGTTCTCTTTTGATAGGATCCTGTTTCCTATGTGTGCAAAATAAAAATAAAT

>25487_25487_6_EGFR-VOPP1_EGFR_chr7_55268106_ENST00000454757_VOPP1_chr7_55588823_ENST00000545390_length(amino acids)=1096AA_BP=941
MGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKT
GLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCS
GRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRA
CGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKE
ITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKI
ISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCI
QCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRR
RHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEIL
DEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH
VKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT
IDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQCTEAKKHCWYFEGLYPTYYICRSYEDCCGSRCCVRALSIQRLWYFWFL
LMMGVLFCCGAGFFIRRRMYPPPLIEEPAFNVSYTRQPPNPGPGAQQPGPPYYTDPGGPGMNPVGNSMAMAFQVPPNSPQGSVACPPPPA

--------------------------------------------------------------
>25487_25487_7_EGFR-VOPP1_EGFR_chr7_55268106_ENST00000455089_VOPP1_chr7_55588823_ENST00000285279_length(transcript)=5775nt_BP=3068nt
GTCCGGGCAGCCCCCGGCGCAGCGCGGCCGCAGCAGCCTCCGCCCCCCGCACGGTGTGAGCGCCCGACGCGGCCGAGGCGGCCGGAGTCC
CGAGCTAGCCCCGGCGGCCGCCGCCGCCCAGACCGGACGACAGGCCACCTCGTCGGCGTCCGCCCGAGTCCCCGCCTCGCCGCCAACGCC
ACAACCACCGCGCACGGCCCCCTGACTCCGTCCAGTATTGATCGGGAGAGCCGGAGCGAGCTCTTCGGGGAGCAGCGATGCGACCCTCCG
GGACGGCCGGGGCAGCGCTCCTGGCGCTGCTGGCTGCGCTCTGCCCGGCGAGTCGGGCTCTGGAGGAAAAGAAAGTTTGCCAAGGCACGA
GTAACAAGCTCACGCAGTTGGGCACTTTTGAAGATCATTTTCTCAGCCTCCAGAGGATGTTCAATAACTGTGAGGTGGTCCTTGGGAATT
TGGAAATTACCTATGTGCAGAGGAATTATGATCTTTCCTTCTTAAAGACCATCCAGGAGGTGGCTGGTTATGTCCTCATTGCCCTCAACA
CAGTGGAGCGAATTCCTTTGGAAAACCTGCAGATCATCAGAGGAAATATGTACTACGAAAATTCCTATGCCTTAGCAGTCTTATCTAACT
ATGATGCAAATAAAACCGGACTGAAGGAGCTGCCCATGAGAAATTTACAGGGCCAAAAGTGTGATCCAAGCTGTCCCAATGGGAGCTGCT
GGGGTGCAGGAGAGGAGAACTGCCAGAAACTGACCAAAATCATCTGTGCCCAGCAGTGCTCCGGGCGCTGCCGTGGCAAGTCCCCCAGTG
ACTGCTGCCACAACCAGTGTGCTGCAGGCTGCACAGGCCCCCGGGAGAGCGACTGCCTGGTCTGCCGCAAATTCCGAGACGAAGCCACGT
GCAAGGACACCTGCCCCCCACTCATGCTCTACAACCCCACCACGTACCAGATGGATGTGAACCCCGAGGGCAAATACAGCTTTGGTGCCA
CCTGCGTGAAGAAGTGTCCCCGTAATTATGTGGTGACAGATCACGGCTCGTGCGTCCGAGCCTGTGGGGCCGACAGCTATGAGATGGAGG
AAGACGGCGTCCGCAAGTGTAAGAAGTGCGAAGGGCCTTGCCGCAAAGTGTGTAACGGAATAGGTATTGGTGAATTTAAAGACTCACTCT
CCATAAATGCTACGAATATTAAACACTTCAAAAACTGCACCTCCATCAGTGGCGATCTCCACATCCTGCCGGTGGCATTTAGGGGTGACT
CCTTCACACATACTCCTCCTCTGGATCCACAGGAACTGGATATTCTGAAAACCGTAAAGGAAATCACAGGGTTTTTGCTGATTCAGGCTT
GGCCTGAAAACAGGACGGACCTCCATGCCTTTGAGAACCTAGAAATCATACGCGGCAGGACCAAGCAACATGGTCAGTTTTCTCTTGCAG
TCGTCAGCCTGAACATAACATCCTTGGGATTACGCTCCCTCAAGGAGATAAGTGATGGAGATGTGATAATTTCAGGAAACAAAAATTTGT
GCTATGCAAATACAATAAACTGGAAAAAACTGTTTGGGACCTCCGGTCAGAAAACCAAAATTATAAGCAACAGAGGTGAAAACAGCTGCA
AGGCCACAGGCCAGGTCTGCCATGCCTTGTGCTCCCCCGAGGGCTGCTGGGGCCCGGAGCCCAGGGACTGCGTCTCTTGCCGGAATGTCA
GCCGAGGCAGGGAATGCGTGGACAAGTGCAACCTTCTGGAGGGTGAGCCAAGGGAGTTTGTGGAGAACTCTGAGTGCATACAGTGCCACC
CAGAGTGCCTGCCTCAGGCCATGAACATCACCTGCACAGGACGGGGACCAGACAACTGTATCCAGTGTGCCCACTACATTGACGGCCCCC
ACTGCGTCAAGACCTGCCCGGCAGGAGTCATGGGAGAAAACAACACCCTGGTCTGGAAGTACGCAGACGCCGGCCATGTGTGCCACCTGT
GCCATCCAAACTGCACCTACGGATGCACTGGGCCAGGTCTTGAAGGCTGTCCAACGAATGGGCCTAAGATCCCGTCCATCGCCACTGGGA
TGGTGGGGGCCCTCCTCTTGCTGCTGGTGGTGGCCCTGGGGATCGGCCTCTTCATGCGAAGGCGCCACATCGTTCGGAAGCGCACGCTGC
GGAGGCTGCTGCAGGAGAGGGAGCTTGTGGAGCCTCTTACACCCAGTGGAGAAGCTCCCAACCAAGCTCTCTTGAGGATCTTGAAGGAAA
CTGAATTCAAAAAGATCAAAGTGCTGGGCTCCGGTGCGTTCGGCACGGTGTATAAGGGACTCTGGATCCCAGAAGGTGAGAAAGTTAAAA
TTCCCGTCGCTATCAAGGAATTAAGAGAAGCAACATCTCCGAAAGCCAACAAGGAAATCCTCGATGAAGCCTACGTGATGGCCAGCGTGG
ACAACCCCCACGTGTGCCGCCTGCTGGGCATCTGCCTCACCTCCACCGTGCAGCTCATCACGCAGCTCATGCCCTTCGGCTGCCTCCTGG
ACTATGTCCGGGAACACAAAGACAATATTGGCTCCCAGTACCTGCTCAACTGGTGTGTGCAGATCGCAAAGGGCATGAACTACTTGGAGG
ACCGTCGCTTGGTGCACCGCGACCTGGCAGCCAGGAACGTACTGGTGAAAACACCGCAGCATGTCAAGATCACAGATTTTGGGCTGGCCA
AACTGCTGGGTGCGGAAGAGAAAGAATACCATGCAGAAGGAGGCAAAGTGCCTATCAAGTGGATGGCATTGGAATCAATTTTACACAGAA
TCTATACCCACCAGAGTGATGTCTGGAGCTACGGGGTGACTGTTTGGGAGTTGATGACCTTTGGATCCAAGCCATATGACGGAATCCCTG
CCAGCGAGATCTCCTCCATCCTGGAGAAAGGAGAACGCCTCCCTCAGCCACCCATATGTACCATCGATGTCTACATGATCATGGTCAAGT
GCTGGATGATAGACGCAGATAGTCGCCCAAAGTTCCGTGAGTTGATCATCGAATTCTCCAAAATGGCCCGAGACCCCCAGCGCTACCTTG
TCATTCAGTGCACAGAAGCCAAAAAGCATTGCTGGTATTTCGAAGGACTCTATCCAACCTATTATATATGCCGCTCCTACGAGGACTGCT
GTGGCTCCAGGTGCTGTGTGCGGGCCCTCTCCATACAGAGGCTGTGGTACTTCTGGTTCCTTCTGATGATGGGCGTGCTTTTCTGCTGCG
GAGCCGGCTTCTTCATCCGGAGGCGCATGTACCCCCCGCCGCTGATCGAGGAGCCAGCCTTCAATGTGTCCTACACCAGGCAGCCCCCAA
ATCCCGGCCCAGGAGCCCAGCAGCCGGGGCCGCCCTATTACACCGACCCAGGAGGACCGGGGATGAACCCTGTCGGGAATTCCATGGCAA
TGGCTTTCCAGGTCCCACCCAACTCACCCCAGGGGAGTGTGGCCTGCCCGCCCCCTCCAGCCTACTGCAACACGCCTCCGCCCCCGTACG
AACAGGTAGTGAAGGCCAAGTAGTGGGGTGCCCACGTGCAAGAGGAGAGACAGGAGAGGGCCTTTCCCTGGCCTTTCTGTCTTCGTTGAT
GTTCACTTCCAGGAACGGTCTCGTGGGCTGCTAAGGGCAGTTCCTCTGATATCCTCACAGCAAGCACAGCTCTCTTTCAGGCTTTCCATG
GAGTACAATATATGAACTCACACTTTGTCTCCTCTGTTGCTTCTGTTTCTGACGCAGTCTGTGCTCTCACATGGTAGTGTGGTGACAGTC
CCCGAGGGCTGACGTCCTTACGGTGGCGTGACCAGATCTACAGGAGAGAGACTGAGAGGAAGAAGGCAGTGCTGGAGGTGCAGGTGGCAT
GTAGAGGGGCCAGGCCGAGCATCCCAGGCAAGCATCCTTCTGCCCGGGTATTAATAGGAAGCCCCATGCCGGGCGGCTCAGCCGATGAAG
CAGCAGCCGACTGAGCTGAGCCCAGCAGGTCATCTGCTCCAGCCTGTCCTCTCGTCAGCCTTCCTCTTCCAGAAGCTGTTGGAGAGACAT
TCAGGAGAGAGCAAGCCCCTTGTCATGTTTCTGTCTCTGTTCATATCCTAAAGATAGACTTCTCCTGCACCGCCAGGGAAGGGTAGCACG
TGCAGCTCTCACCGCAGGATGGGGCCTAGAATCAGGCTTGCCTTGGAGGCCTGACAGTGATCTGACATCCACTAAGCAAATTTATTTAAA
TTCATGGGAAATCACTTCCTGCCCCAAACTGAGACATTGCATTTTGTGAGCTCTTGGTCTGATTTGGAGAAAGGACTGTTACCCATTTTT
TTGGTGTGTTTATGGAAGTGCATGTAGAGCGTCCTGCCCTTTGAAATCAGACTGGGTGTGTGTCTTCCCTGGACATCACTGCCTCTCCAG
GGCATTCTCAGGCCCGGGGGTCTCCTTCCCTCAGGCAGCTCCAGTGGTGGGTTCTGAAGGGTGCTTTCAAAACGGGGCACATCTGGCTGG
GAAGTCACATGGACTCTTCCAGGGAGAGAGACCAGCTGAGGCGTCTCTCTCTGAGGTTGTGTTGGGTCTAAGCGGGTGTGTGCTGGGCTC
CAAGGAGGAGGAGCTTGCTGGGAAAAGACAGGAGAAGTACTGACTCAACTGCACTGACCATGTTGTCATAATTAGAATAAAGAAGAAGTG
GTCGGAAATGCACATTCCTGGATAGGAATCACAGCTCACCCCAGGATCTCACAGGTAGTCTCCTGAGTAGTTGACGGCTAGCGGGGAGCT
AGTTCCGCCGCATAGTTATAGTGTTGATGTGTGAACGCTGACCTGTCCTGTGTGCTAAGAGCTATGCAGCTTAGCTGAGGCGCCTAGATT
ACTAGATGTGCTGTATCACGGGGAATGAGGTGGGGGTGCTTATTTTTTAATGAACTAATCAGAGCCTCTTGAGAAATTGTTACTCATTGA
ACTGGAGCATCAAGACATCTCATGGAAGTGGATACGGAGTGATTTGGTGTCCATGCTTTTCACTCTGAGGACATTTAATCGGAGAACCTC
CTGGGGAATTTTGTGGGAGACACTTGGGAACAAAACAGACACCCTGGGAATGCAGTTGCAAGCACAGATGCTGCCACCAGTGTCTCTGAC
CACCCTGGTGTGACTGCTGACTGCCAGCGTGGTACCTCCCATGCTGCAGGCCTCCATCTAAATGAGACAACAAAGCACAATGTTCACTGT
TTACAACCAAGACAACTGCGTGGGTCCAAACACTCCTCTTCCTCCAGGTCATTTGTTTTGCATTTTTAATGTCTTTATTTTTTGTAATGA
AAAAGCACACTAAGCTGCCCCTGGAATCGGGTGCAGCTGAATAGGCACCCAAAAGTCCGTGACTAAATTTCGTTTGTCTTTTTGATAGCA
AATTATGTTAAGAGACAGTGATGGCTAGGGCTCAACAATTTTGTATTCCCATGTTTGTGTGAGACAGAGTTTGTTTTCCCTTGAACTTGG
TTAGAATTGTGCTACTGTGAACGCTGATCCTGCATATGGAAGTCCCACTTCGGTGACATTTCCTGGCCATTCTTGTTTCCATTGTGTGGA
TGGTGGGTTGTGCCCACTTCCTGGAGTGAGACAGCTCCTGGTGTGTAGAATTCCCGGAGCGTCCGTGGTTCAGAGTAAACTTGAAGCAGA
TCTGTGCATGCTTTTCCTCTGCAACAATTGGCTCGTTTCTCTTTTTTGTTCTCTTTTGATAGGATCCTGTTTCCTATGTGTGCAAAATAA

>25487_25487_7_EGFR-VOPP1_EGFR_chr7_55268106_ENST00000455089_VOPP1_chr7_55588823_ENST00000285279_length(amino acids)=1091AA_BP=936
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVL
IALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQGQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRG
KSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADS
YEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFL
LIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRG
ENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHY
IDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVR
KRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYV
MASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITD
FGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYM
IMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQCTEAKKHCWYFEGLYPTYYICRSYEDCCGSRCCVRALSIQRLWYFWFLLMMGV
LFCCGAGFFIRRRMYPPPLIEEPAFNVSYTRQPPNPGPGAQQPGPPYYTDPGGPGMNPVGNSMAMAFQVPPNSPQGSVACPPPPAYCNTP

--------------------------------------------------------------
>25487_25487_8_EGFR-VOPP1_EGFR_chr7_55268106_ENST00000455089_VOPP1_chr7_55588823_ENST00000433959_length(transcript)=5774nt_BP=3068nt
GTCCGGGCAGCCCCCGGCGCAGCGCGGCCGCAGCAGCCTCCGCCCCCCGCACGGTGTGAGCGCCCGACGCGGCCGAGGCGGCCGGAGTCC
CGAGCTAGCCCCGGCGGCCGCCGCCGCCCAGACCGGACGACAGGCCACCTCGTCGGCGTCCGCCCGAGTCCCCGCCTCGCCGCCAACGCC
ACAACCACCGCGCACGGCCCCCTGACTCCGTCCAGTATTGATCGGGAGAGCCGGAGCGAGCTCTTCGGGGAGCAGCGATGCGACCCTCCG
GGACGGCCGGGGCAGCGCTCCTGGCGCTGCTGGCTGCGCTCTGCCCGGCGAGTCGGGCTCTGGAGGAAAAGAAAGTTTGCCAAGGCACGA
GTAACAAGCTCACGCAGTTGGGCACTTTTGAAGATCATTTTCTCAGCCTCCAGAGGATGTTCAATAACTGTGAGGTGGTCCTTGGGAATT
TGGAAATTACCTATGTGCAGAGGAATTATGATCTTTCCTTCTTAAAGACCATCCAGGAGGTGGCTGGTTATGTCCTCATTGCCCTCAACA
CAGTGGAGCGAATTCCTTTGGAAAACCTGCAGATCATCAGAGGAAATATGTACTACGAAAATTCCTATGCCTTAGCAGTCTTATCTAACT
ATGATGCAAATAAAACCGGACTGAAGGAGCTGCCCATGAGAAATTTACAGGGCCAAAAGTGTGATCCAAGCTGTCCCAATGGGAGCTGCT
GGGGTGCAGGAGAGGAGAACTGCCAGAAACTGACCAAAATCATCTGTGCCCAGCAGTGCTCCGGGCGCTGCCGTGGCAAGTCCCCCAGTG
ACTGCTGCCACAACCAGTGTGCTGCAGGCTGCACAGGCCCCCGGGAGAGCGACTGCCTGGTCTGCCGCAAATTCCGAGACGAAGCCACGT
GCAAGGACACCTGCCCCCCACTCATGCTCTACAACCCCACCACGTACCAGATGGATGTGAACCCCGAGGGCAAATACAGCTTTGGTGCCA
CCTGCGTGAAGAAGTGTCCCCGTAATTATGTGGTGACAGATCACGGCTCGTGCGTCCGAGCCTGTGGGGCCGACAGCTATGAGATGGAGG
AAGACGGCGTCCGCAAGTGTAAGAAGTGCGAAGGGCCTTGCCGCAAAGTGTGTAACGGAATAGGTATTGGTGAATTTAAAGACTCACTCT
CCATAAATGCTACGAATATTAAACACTTCAAAAACTGCACCTCCATCAGTGGCGATCTCCACATCCTGCCGGTGGCATTTAGGGGTGACT
CCTTCACACATACTCCTCCTCTGGATCCACAGGAACTGGATATTCTGAAAACCGTAAAGGAAATCACAGGGTTTTTGCTGATTCAGGCTT
GGCCTGAAAACAGGACGGACCTCCATGCCTTTGAGAACCTAGAAATCATACGCGGCAGGACCAAGCAACATGGTCAGTTTTCTCTTGCAG
TCGTCAGCCTGAACATAACATCCTTGGGATTACGCTCCCTCAAGGAGATAAGTGATGGAGATGTGATAATTTCAGGAAACAAAAATTTGT
GCTATGCAAATACAATAAACTGGAAAAAACTGTTTGGGACCTCCGGTCAGAAAACCAAAATTATAAGCAACAGAGGTGAAAACAGCTGCA
AGGCCACAGGCCAGGTCTGCCATGCCTTGTGCTCCCCCGAGGGCTGCTGGGGCCCGGAGCCCAGGGACTGCGTCTCTTGCCGGAATGTCA
GCCGAGGCAGGGAATGCGTGGACAAGTGCAACCTTCTGGAGGGTGAGCCAAGGGAGTTTGTGGAGAACTCTGAGTGCATACAGTGCCACC
CAGAGTGCCTGCCTCAGGCCATGAACATCACCTGCACAGGACGGGGACCAGACAACTGTATCCAGTGTGCCCACTACATTGACGGCCCCC
ACTGCGTCAAGACCTGCCCGGCAGGAGTCATGGGAGAAAACAACACCCTGGTCTGGAAGTACGCAGACGCCGGCCATGTGTGCCACCTGT
GCCATCCAAACTGCACCTACGGATGCACTGGGCCAGGTCTTGAAGGCTGTCCAACGAATGGGCCTAAGATCCCGTCCATCGCCACTGGGA
TGGTGGGGGCCCTCCTCTTGCTGCTGGTGGTGGCCCTGGGGATCGGCCTCTTCATGCGAAGGCGCCACATCGTTCGGAAGCGCACGCTGC
GGAGGCTGCTGCAGGAGAGGGAGCTTGTGGAGCCTCTTACACCCAGTGGAGAAGCTCCCAACCAAGCTCTCTTGAGGATCTTGAAGGAAA
CTGAATTCAAAAAGATCAAAGTGCTGGGCTCCGGTGCGTTCGGCACGGTGTATAAGGGACTCTGGATCCCAGAAGGTGAGAAAGTTAAAA
TTCCCGTCGCTATCAAGGAATTAAGAGAAGCAACATCTCCGAAAGCCAACAAGGAAATCCTCGATGAAGCCTACGTGATGGCCAGCGTGG
ACAACCCCCACGTGTGCCGCCTGCTGGGCATCTGCCTCACCTCCACCGTGCAGCTCATCACGCAGCTCATGCCCTTCGGCTGCCTCCTGG
ACTATGTCCGGGAACACAAAGACAATATTGGCTCCCAGTACCTGCTCAACTGGTGTGTGCAGATCGCAAAGGGCATGAACTACTTGGAGG
ACCGTCGCTTGGTGCACCGCGACCTGGCAGCCAGGAACGTACTGGTGAAAACACCGCAGCATGTCAAGATCACAGATTTTGGGCTGGCCA
AACTGCTGGGTGCGGAAGAGAAAGAATACCATGCAGAAGGAGGCAAAGTGCCTATCAAGTGGATGGCATTGGAATCAATTTTACACAGAA
TCTATACCCACCAGAGTGATGTCTGGAGCTACGGGGTGACTGTTTGGGAGTTGATGACCTTTGGATCCAAGCCATATGACGGAATCCCTG
CCAGCGAGATCTCCTCCATCCTGGAGAAAGGAGAACGCCTCCCTCAGCCACCCATATGTACCATCGATGTCTACATGATCATGGTCAAGT
GCTGGATGATAGACGCAGATAGTCGCCCAAAGTTCCGTGAGTTGATCATCGAATTCTCCAAAATGGCCCGAGACCCCCAGCGCTACCTTG
TCATTCAGTGCACAGAAGCCAAAAAGCATTGCTGGTATTTCGAAGGACTCTATCCAACCTATTATATATGCCGCTCCTACGAGGACTGCT
GTGGCTCCAGGTGCTGTGTGCGGGCCCTCTCCATACAGAGGCTGTGGTACTTCTGGTTCCTTCTGATGATGGGCGTGCTTTTCTGCTGCG
GAGCCGGCTTCTTCATCCGGAGGCGCATGTACCCCCCGCCGCTGATCGAGGAGCCAGCCTTCAATGTGTCCTACACCAGGCAGCCCCCAA
ATCCCGGCCCAGGAGCCCAGCAGCCGGGGCCGCCCTATTACACCGACCCAGGAGGACCGGGGATGAACCCTGTCGGGAATTCCATGGCAA
TGGCTTTCCAGGTCCCACCCAACTCACCCCAGGGGAGTGTGGCCTGCCCGCCCCCTCCAGCCTACTGCAACACGCCTCCGCCCCCGTACG
AACAGGTAGTGAAGGCCAAGTAGTGGGGTGCCCACGTGCAAGAGGAGAGACAGGAGAGGGCCTTTCCCTGGCCTTTCTGTCTTCGTTGAT
GTTCACTTCCAGGAACGGTCTCGTGGGCTGCTAAGGGCAGTTCCTCTGATATCCTCACAGCAAGCACAGCTCTCTTTCAGGCTTTCCATG
GAGTACAATATATGAACTCACACTTTGTCTCCTCTGTTGCTTCTGTTTCTGACGCAGTCTGTGCTCTCACATGGTAGTGTGGTGACAGTC
CCCGAGGGCTGACGTCCTTACGGTGGCGTGACCAGATCTACAGGAGAGAGACTGAGAGGAAGAAGGCAGTGCTGGAGGTGCAGGTGGCAT
GTAGAGGGGCCAGGCCGAGCATCCCAGGCAAGCATCCTTCTGCCCGGGTATTAATAGGAAGCCCCATGCCGGGCGGCTCAGCCGATGAAG
CAGCAGCCGACTGAGCTGAGCCCAGCAGGTCATCTGCTCCAGCCTGTCCTCTCGTCAGCCTTCCTCTTCCAGAAGCTGTTGGAGAGACAT
TCAGGAGAGAGCAAGCCCCTTGTCATGTTTCTGTCTCTGTTCATATCCTAAAGATAGACTTCTCCTGCACCGCCAGGGAAGGGTAGCACG
TGCAGCTCTCACCGCAGGATGGGGCCTAGAATCAGGCTTGCCTTGGAGGCCTGACAGTGATCTGACATCCACTAAGCAAATTTATTTAAA
TTCATGGGAAATCACTTCCTGCCCCAAACTGAGACATTGCATTTTGTGAGCTCTTGGTCTGATTTGGAGAAAGGACTGTTACCCATTTTT
TTGGTGTGTTTATGGAAGTGCATGTAGAGCGTCCTGCCCTTTGAAATCAGACTGGGTGTGTGTCTTCCCTGGACATCACTGCCTCTCCAG
GGCATTCTCAGGCCCGGGGGTCTCCTTCCCTCAGGCAGCTCCAGTGGTGGGTTCTGAAGGGTGCTTTCAAAACGGGGCACATCTGGCTGG
GAAGTCACATGGACTCTTCCAGGGAGAGAGACCAGCTGAGGCGTCTCTCTCTGAGGTTGTGTTGGGTCTAAGCGGGTGTGTGCTGGGCTC
CAAGGAGGAGGAGCTTGCTGGGAAAAGACAGGAGAAGTACTGACTCAACTGCACTGACCATGTTGTCATAATTAGAATAAAGAAGAAGTG
GTCGGAAATGCACATTCCTGGATAGGAATCACAGCTCACCCCAGGATCTCACAGGTAGTCTCCTGAGTAGTTGACGGCTAGCGGGGAGCT
AGTTCCGCCGCATAGTTATAGTGTTGATGTGTGAACGCTGACCTGTCCTGTGTGCTAAGAGCTATGCAGCTTAGCTGAGGCGCCTAGATT
ACTAGATGTGCTGTATCACGGGGAATGAGGTGGGGGTGCTTATTTTTTAATGAACTAATCAGAGCCTCTTGAGAAATTGTTACTCATTGA
ACTGGAGCATCAAGACATCTCATGGAAGTGGATACGGAGTGATTTGGTGTCCATGCTTTTCACTCTGAGGACATTTAATCGGAGAACCTC
CTGGGGAATTTTGTGGGAGACACTTGGGAACAAAACAGACACCCTGGGAATGCAGTTGCAAGCACAGATGCTGCCACCAGTGTCTCTGAC
CACCCTGGTGTGACTGCTGACTGCCAGCGTGGTACCTCCCATGCTGCAGGCCTCCATCTAAATGAGACAACAAAGCACAATGTTCACTGT
TTACAACCAAGACAACTGCGTGGGTCCAAACACTCCTCTTCCTCCAGGTCATTTGTTTTGCATTTTTAATGTCTTTATTTTTTGTAATGA
AAAAGCACACTAAGCTGCCCCTGGAATCGGGTGCAGCTGAATAGGCACCCAAAAGTCCGTGACTAAATTTCGTTTGTCTTTTTGATAGCA
AATTATGTTAAGAGACAGTGATGGCTAGGGCTCAACAATTTTGTATTCCCATGTTTGTGTGAGACAGAGTTTGTTTTCCCTTGAACTTGG
TTAGAATTGTGCTACTGTGAACGCTGATCCTGCATATGGAAGTCCCACTTCGGTGACATTTCCTGGCCATTCTTGTTTCCATTGTGTGGA
TGGTGGGTTGTGCCCACTTCCTGGAGTGAGACAGCTCCTGGTGTGTAGAATTCCCGGAGCGTCCGTGGTTCAGAGTAAACTTGAAGCAGA
TCTGTGCATGCTTTTCCTCTGCAACAATTGGCTCGTTTCTCTTTTTTGTTCTCTTTTGATAGGATCCTGTTTCCTATGTGTGCAAAATAA

>25487_25487_8_EGFR-VOPP1_EGFR_chr7_55268106_ENST00000455089_VOPP1_chr7_55588823_ENST00000433959_length(amino acids)=1091AA_BP=936
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVL
IALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQGQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRG
KSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADS
YEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFL
LIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRG
ENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHY
IDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVR
KRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYV
MASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITD
FGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYM
IMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQCTEAKKHCWYFEGLYPTYYICRSYEDCCGSRCCVRALSIQRLWYFWFLLMMGV
LFCCGAGFFIRRRMYPPPLIEEPAFNVSYTRQPPNPGPGAQQPGPPYYTDPGGPGMNPVGNSMAMAFQVPPNSPQGSVACPPPPAYCNTP

--------------------------------------------------------------
>25487_25487_9_EGFR-VOPP1_EGFR_chr7_55268106_ENST00000455089_VOPP1_chr7_55588823_ENST00000545390_length(transcript)=5774nt_BP=3068nt
GTCCGGGCAGCCCCCGGCGCAGCGCGGCCGCAGCAGCCTCCGCCCCCCGCACGGTGTGAGCGCCCGACGCGGCCGAGGCGGCCGGAGTCC
CGAGCTAGCCCCGGCGGCCGCCGCCGCCCAGACCGGACGACAGGCCACCTCGTCGGCGTCCGCCCGAGTCCCCGCCTCGCCGCCAACGCC
ACAACCACCGCGCACGGCCCCCTGACTCCGTCCAGTATTGATCGGGAGAGCCGGAGCGAGCTCTTCGGGGAGCAGCGATGCGACCCTCCG
GGACGGCCGGGGCAGCGCTCCTGGCGCTGCTGGCTGCGCTCTGCCCGGCGAGTCGGGCTCTGGAGGAAAAGAAAGTTTGCCAAGGCACGA
GTAACAAGCTCACGCAGTTGGGCACTTTTGAAGATCATTTTCTCAGCCTCCAGAGGATGTTCAATAACTGTGAGGTGGTCCTTGGGAATT
TGGAAATTACCTATGTGCAGAGGAATTATGATCTTTCCTTCTTAAAGACCATCCAGGAGGTGGCTGGTTATGTCCTCATTGCCCTCAACA
CAGTGGAGCGAATTCCTTTGGAAAACCTGCAGATCATCAGAGGAAATATGTACTACGAAAATTCCTATGCCTTAGCAGTCTTATCTAACT
ATGATGCAAATAAAACCGGACTGAAGGAGCTGCCCATGAGAAATTTACAGGGCCAAAAGTGTGATCCAAGCTGTCCCAATGGGAGCTGCT
GGGGTGCAGGAGAGGAGAACTGCCAGAAACTGACCAAAATCATCTGTGCCCAGCAGTGCTCCGGGCGCTGCCGTGGCAAGTCCCCCAGTG
ACTGCTGCCACAACCAGTGTGCTGCAGGCTGCACAGGCCCCCGGGAGAGCGACTGCCTGGTCTGCCGCAAATTCCGAGACGAAGCCACGT
GCAAGGACACCTGCCCCCCACTCATGCTCTACAACCCCACCACGTACCAGATGGATGTGAACCCCGAGGGCAAATACAGCTTTGGTGCCA
CCTGCGTGAAGAAGTGTCCCCGTAATTATGTGGTGACAGATCACGGCTCGTGCGTCCGAGCCTGTGGGGCCGACAGCTATGAGATGGAGG
AAGACGGCGTCCGCAAGTGTAAGAAGTGCGAAGGGCCTTGCCGCAAAGTGTGTAACGGAATAGGTATTGGTGAATTTAAAGACTCACTCT
CCATAAATGCTACGAATATTAAACACTTCAAAAACTGCACCTCCATCAGTGGCGATCTCCACATCCTGCCGGTGGCATTTAGGGGTGACT
CCTTCACACATACTCCTCCTCTGGATCCACAGGAACTGGATATTCTGAAAACCGTAAAGGAAATCACAGGGTTTTTGCTGATTCAGGCTT
GGCCTGAAAACAGGACGGACCTCCATGCCTTTGAGAACCTAGAAATCATACGCGGCAGGACCAAGCAACATGGTCAGTTTTCTCTTGCAG
TCGTCAGCCTGAACATAACATCCTTGGGATTACGCTCCCTCAAGGAGATAAGTGATGGAGATGTGATAATTTCAGGAAACAAAAATTTGT
GCTATGCAAATACAATAAACTGGAAAAAACTGTTTGGGACCTCCGGTCAGAAAACCAAAATTATAAGCAACAGAGGTGAAAACAGCTGCA
AGGCCACAGGCCAGGTCTGCCATGCCTTGTGCTCCCCCGAGGGCTGCTGGGGCCCGGAGCCCAGGGACTGCGTCTCTTGCCGGAATGTCA
GCCGAGGCAGGGAATGCGTGGACAAGTGCAACCTTCTGGAGGGTGAGCCAAGGGAGTTTGTGGAGAACTCTGAGTGCATACAGTGCCACC
CAGAGTGCCTGCCTCAGGCCATGAACATCACCTGCACAGGACGGGGACCAGACAACTGTATCCAGTGTGCCCACTACATTGACGGCCCCC
ACTGCGTCAAGACCTGCCCGGCAGGAGTCATGGGAGAAAACAACACCCTGGTCTGGAAGTACGCAGACGCCGGCCATGTGTGCCACCTGT
GCCATCCAAACTGCACCTACGGATGCACTGGGCCAGGTCTTGAAGGCTGTCCAACGAATGGGCCTAAGATCCCGTCCATCGCCACTGGGA
TGGTGGGGGCCCTCCTCTTGCTGCTGGTGGTGGCCCTGGGGATCGGCCTCTTCATGCGAAGGCGCCACATCGTTCGGAAGCGCACGCTGC
GGAGGCTGCTGCAGGAGAGGGAGCTTGTGGAGCCTCTTACACCCAGTGGAGAAGCTCCCAACCAAGCTCTCTTGAGGATCTTGAAGGAAA
CTGAATTCAAAAAGATCAAAGTGCTGGGCTCCGGTGCGTTCGGCACGGTGTATAAGGGACTCTGGATCCCAGAAGGTGAGAAAGTTAAAA
TTCCCGTCGCTATCAAGGAATTAAGAGAAGCAACATCTCCGAAAGCCAACAAGGAAATCCTCGATGAAGCCTACGTGATGGCCAGCGTGG
ACAACCCCCACGTGTGCCGCCTGCTGGGCATCTGCCTCACCTCCACCGTGCAGCTCATCACGCAGCTCATGCCCTTCGGCTGCCTCCTGG
ACTATGTCCGGGAACACAAAGACAATATTGGCTCCCAGTACCTGCTCAACTGGTGTGTGCAGATCGCAAAGGGCATGAACTACTTGGAGG
ACCGTCGCTTGGTGCACCGCGACCTGGCAGCCAGGAACGTACTGGTGAAAACACCGCAGCATGTCAAGATCACAGATTTTGGGCTGGCCA
AACTGCTGGGTGCGGAAGAGAAAGAATACCATGCAGAAGGAGGCAAAGTGCCTATCAAGTGGATGGCATTGGAATCAATTTTACACAGAA
TCTATACCCACCAGAGTGATGTCTGGAGCTACGGGGTGACTGTTTGGGAGTTGATGACCTTTGGATCCAAGCCATATGACGGAATCCCTG
CCAGCGAGATCTCCTCCATCCTGGAGAAAGGAGAACGCCTCCCTCAGCCACCCATATGTACCATCGATGTCTACATGATCATGGTCAAGT
GCTGGATGATAGACGCAGATAGTCGCCCAAAGTTCCGTGAGTTGATCATCGAATTCTCCAAAATGGCCCGAGACCCCCAGCGCTACCTTG
TCATTCAGTGCACAGAAGCCAAAAAGCATTGCTGGTATTTCGAAGGACTCTATCCAACCTATTATATATGCCGCTCCTACGAGGACTGCT
GTGGCTCCAGGTGCTGTGTGCGGGCCCTCTCCATACAGAGGCTGTGGTACTTCTGGTTCCTTCTGATGATGGGCGTGCTTTTCTGCTGCG
GAGCCGGCTTCTTCATCCGGAGGCGCATGTACCCCCCGCCGCTGATCGAGGAGCCAGCCTTCAATGTGTCCTACACCAGGCAGCCCCCAA
ATCCCGGCCCAGGAGCCCAGCAGCCGGGGCCGCCCTATTACACCGACCCAGGAGGACCGGGGATGAACCCTGTCGGGAATTCCATGGCAA
TGGCTTTCCAGGTCCCACCCAACTCACCCCAGGGGAGTGTGGCCTGCCCGCCCCCTCCAGCCTACTGCAACACGCCTCCGCCCCCGTACG
AACAGGTAGTGAAGGCCAAGTAGTGGGGTGCCCACGTGCAAGAGGAGAGACAGGAGAGGGCCTTTCCCTGGCCTTTCTGTCTTCGTTGAT
GTTCACTTCCAGGAACGGTCTCGTGGGCTGCTAAGGGCAGTTCCTCTGATATCCTCACAGCAAGCACAGCTCTCTTTCAGGCTTTCCATG
GAGTACAATATATGAACTCACACTTTGTCTCCTCTGTTGCTTCTGTTTCTGACGCAGTCTGTGCTCTCACATGGTAGTGTGGTGACAGTC
CCCGAGGGCTGACGTCCTTACGGTGGCGTGACCAGATCTACAGGAGAGAGACTGAGAGGAAGAAGGCAGTGCTGGAGGTGCAGGTGGCAT
GTAGAGGGGCCAGGCCGAGCATCCCAGGCAAGCATCCTTCTGCCCGGGTATTAATAGGAAGCCCCATGCCGGGCGGCTCAGCCGATGAAG
CAGCAGCCGACTGAGCTGAGCCCAGCAGGTCATCTGCTCCAGCCTGTCCTCTCGTCAGCCTTCCTCTTCCAGAAGCTGTTGGAGAGACAT
TCAGGAGAGAGCAAGCCCCTTGTCATGTTTCTGTCTCTGTTCATATCCTAAAGATAGACTTCTCCTGCACCGCCAGGGAAGGGTAGCACG
TGCAGCTCTCACCGCAGGATGGGGCCTAGAATCAGGCTTGCCTTGGAGGCCTGACAGTGATCTGACATCCACTAAGCAAATTTATTTAAA
TTCATGGGAAATCACTTCCTGCCCCAAACTGAGACATTGCATTTTGTGAGCTCTTGGTCTGATTTGGAGAAAGGACTGTTACCCATTTTT
TTGGTGTGTTTATGGAAGTGCATGTAGAGCGTCCTGCCCTTTGAAATCAGACTGGGTGTGTGTCTTCCCTGGACATCACTGCCTCTCCAG
GGCATTCTCAGGCCCGGGGGTCTCCTTCCCTCAGGCAGCTCCAGTGGTGGGTTCTGAAGGGTGCTTTCAAAACGGGGCACATCTGGCTGG
GAAGTCACATGGACTCTTCCAGGGAGAGAGACCAGCTGAGGCGTCTCTCTCTGAGGTTGTGTTGGGTCTAAGCGGGTGTGTGCTGGGCTC
CAAGGAGGAGGAGCTTGCTGGGAAAAGACAGGAGAAGTACTGACTCAACTGCACTGACCATGTTGTCATAATTAGAATAAAGAAGAAGTG
GTCGGAAATGCACATTCCTGGATAGGAATCACAGCTCACCCCAGGATCTCACAGGTAGTCTCCTGAGTAGTTGACGGCTAGCGGGGAGCT
AGTTCCGCCGCATAGTTATAGTGTTGATGTGTGAACGCTGACCTGTCCTGTGTGCTAAGAGCTATGCAGCTTAGCTGAGGCGCCTAGATT
ACTAGATGTGCTGTATCACGGGGAATGAGGTGGGGGTGCTTATTTTTTAATGAACTAATCAGAGCCTCTTGAGAAATTGTTACTCATTGA
ACTGGAGCATCAAGACATCTCATGGAAGTGGATACGGAGTGATTTGGTGTCCATGCTTTTCACTCTGAGGACATTTAATCGGAGAACCTC
CTGGGGAATTTTGTGGGAGACACTTGGGAACAAAACAGACACCCTGGGAATGCAGTTGCAAGCACAGATGCTGCCACCAGTGTCTCTGAC
CACCCTGGTGTGACTGCTGACTGCCAGCGTGGTACCTCCCATGCTGCAGGCCTCCATCTAAATGAGACAACAAAGCACAATGTTCACTGT
TTACAACCAAGACAACTGCGTGGGTCCAAACACTCCTCTTCCTCCAGGTCATTTGTTTTGCATTTTTAATGTCTTTATTTTTTGTAATGA
AAAAGCACACTAAGCTGCCCCTGGAATCGGGTGCAGCTGAATAGGCACCCAAAAGTCCGTGACTAAATTTCGTTTGTCTTTTTGATAGCA
AATTATGTTAAGAGACAGTGATGGCTAGGGCTCAACAATTTTGTATTCCCATGTTTGTGTGAGACAGAGTTTGTTTTCCCTTGAACTTGG
TTAGAATTGTGCTACTGTGAACGCTGATCCTGCATATGGAAGTCCCACTTCGGTGACATTTCCTGGCCATTCTTGTTTCCATTGTGTGGA
TGGTGGGTTGTGCCCACTTCCTGGAGTGAGACAGCTCCTGGTGTGTAGAATTCCCGGAGCGTCCGTGGTTCAGAGTAAACTTGAAGCAGA
TCTGTGCATGCTTTTCCTCTGCAACAATTGGCTCGTTTCTCTTTTTTGTTCTCTTTTGATAGGATCCTGTTTCCTATGTGTGCAAAATAA

>25487_25487_9_EGFR-VOPP1_EGFR_chr7_55268106_ENST00000455089_VOPP1_chr7_55588823_ENST00000545390_length(amino acids)=1091AA_BP=936
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVL
IALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQGQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRG
KSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADS
YEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFL
LIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRG
ENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHY
IDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVR
KRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYV
MASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITD
FGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYM
IMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQCTEAKKHCWYFEGLYPTYYICRSYEDCCGSRCCVRALSIQRLWYFWFLLMMGV
LFCCGAGFFIRRRMYPPPLIEEPAFNVSYTRQPPNPGPGAQQPGPPYYTDPGGPGMNPVGNSMAMAFQVPPNSPQGSVACPPPPAYCNTP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EGFR-VOPP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for EGFR-VOPP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EGFR-VOPP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEGFRC0007131Non-Small Cell Lung Carcinoma16CGI;CTD_human
HgeneEGFRC0024121Lung Neoplasms7CGI;CTD_human
HgeneEGFRC0242379Malignant neoplasm of lung7CGI;CTD_human
HgeneEGFRC0006142Malignant neoplasm of breast6CTD_human
HgeneEGFRC0678222Breast Carcinoma6CTD_human
HgeneEGFRC1257931Mammary Neoplasms, Human6CTD_human
HgeneEGFRC1458155Mammary Neoplasms6CTD_human
HgeneEGFRC4704874Mammary Carcinoma, Human6CTD_human
HgeneEGFRC0001418Adenocarcinoma5CTD_human
HgeneEGFRC0205641Adenocarcinoma, Basal Cell5CTD_human
HgeneEGFRC0205642Adenocarcinoma, Oxyphilic5CTD_human
HgeneEGFRC0205643Carcinoma, Cribriform5CTD_human
HgeneEGFRC0205644Carcinoma, Granular Cell5CTD_human
HgeneEGFRC0205645Adenocarcinoma, Tubular5CTD_human
HgeneEGFRC0334588Giant Cell Glioblastoma5CTD_human;ORPHANET
HgeneEGFRC0007137Squamous cell carcinoma3CTD_human
HgeneEGFRC0007873Uterine Cervical Neoplasm3CTD_human
HgeneEGFRC0014859Esophageal Neoplasms3CGI;CTD_human
HgeneEGFRC0017636Glioblastoma3CGI;CTD_human
HgeneEGFRC0018671Head and Neck Neoplasms3CGI;CTD_human
HgeneEGFRC0018675Head Neoplasms3CTD_human
HgeneEGFRC0024623Malignant neoplasm of stomach3CTD_human
HgeneEGFRC0027533Neck Neoplasms3CTD_human
HgeneEGFRC0027627Neoplasm Metastasis3CTD_human
HgeneEGFRC0033578Prostatic Neoplasms3CTD_human
HgeneEGFRC0038356Stomach Neoplasms3CTD_human
HgeneEGFRC0278996Malignant Head and Neck Neoplasm3CGI;CTD_human
HgeneEGFRC0376358Malignant neoplasm of prostate3CTD_human
HgeneEGFRC0546837Malignant neoplasm of esophagus3CGI;CTD_human
HgeneEGFRC0746787Cancer of Neck3CTD_human
HgeneEGFRC0751177Cancer of Head3CTD_human
HgeneEGFRC0887900Upper Aerodigestive Tract Neoplasms3CTD_human
HgeneEGFRC1621958Glioblastoma Multiforme3CTD_human
HgeneEGFRC1708349Hereditary Diffuse Gastric Cancer3CTD_human
HgeneEGFRC4048328cervical cancer3CTD_human
HgeneEGFRC0005684Malignant neoplasm of urinary bladder2CTD_human
HgeneEGFRC0005695Bladder Neoplasm2CTD_human
HgeneEGFRC0007102Malignant tumor of colon2CTD_human
HgeneEGFRC0009375Colonic Neoplasms2CTD_human
HgeneEGFRC0009402Colorectal Carcinoma2CTD_human
HgeneEGFRC0009404Colorectal Neoplasms2CTD_human
HgeneEGFRC0024668Mammary Neoplasms, Experimental2CTD_human
HgeneEGFRC0027626Neoplasm Invasiveness2CTD_human
HgeneEGFRC0027643Neoplasm Recurrence, Local2CTD_human
HgeneEGFRC0152013Adenocarcinoma of lung (disorder)2CGI;CTD_human
HgeneEGFRC0206726gliosarcoma2ORPHANET
HgeneEGFRC0919267ovarian neoplasm2CTD_human
HgeneEGFRC1140680Malignant neoplasm of ovary2CTD_human
HgeneEGFRC4015130INFLAMMATORY SKIN AND BOWEL DISEASE, NEONATAL, 22CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneEGFRC0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneEGFRC0003865Arthritis, Adjuvant-Induced1CTD_human
HgeneEGFRC0005396Bile Duct Neoplasms1CTD_human
HgeneEGFRC0007097Carcinoma1CTD_human
HgeneEGFRC0007113Rectal Carcinoma1CTD_human
HgeneEGFRC0007193Cardiomyopathy, Dilated1CTD_human
HgeneEGFRC0011603Dermatitis1CTD_human
HgeneEGFRC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneEGFRC0014175Endometriosis1CTD_human
HgeneEGFRC0016978gallbladder neoplasm1CTD_human
HgeneEGFRC0021655Insulin Resistance1CTD_human
HgeneEGFRC0022660Kidney Failure, Acute1CTD_human
HgeneEGFRC0024667Animal Mammary Neoplasms1CTD_human
HgeneEGFRC0024809Marijuana Abuse1PSYGENET
HgeneEGFRC0025500Mesothelioma1CTD_human
HgeneEGFRC0027439Nasopharyngeal Neoplasms1CTD_human
HgeneEGFRC0029463Osteosarcoma1CTD_human
HgeneEGFRC0030297Pancreatic Neoplasm1CTD_human
HgeneEGFRC0030354Papilloma1CTD_human
HgeneEGFRC0032580Adenomatous Polyposis Coli1CTD_human
HgeneEGFRC0034885Rectal Neoplasms1CTD_human
HgeneEGFRC0041696Unipolar Depression1PSYGENET
HgeneEGFRC0085548Autosomal Recessive Polycystic Kidney Disease1CTD_human
HgeneEGFRC0085762Alcohol abuse1PSYGENET
HgeneEGFRC0149925Small cell carcinoma of lung1CTD_human
HgeneEGFRC0153452Malignant neoplasm of gallbladder1CTD_human
HgeneEGFRC0205696Anaplastic carcinoma1CTD_human
HgeneEGFRC0205697Carcinoma, Spindle-Cell1CTD_human
HgeneEGFRC0205698Undifferentiated carcinoma1CTD_human
HgeneEGFRC0205699Carcinomatosis1CTD_human
HgeneEGFRC0205874Papilloma, Squamous Cell1CTD_human
HgeneEGFRC0205875Papillomatosis1CTD_human
HgeneEGFRC0206686Adrenocortical carcinoma1CTD_human
HgeneEGFRC0206698Cholangiocarcinoma1CTD_human
HgeneEGFRC0235874Disease Exacerbation1CTD_human
HgeneEGFRC0238301Cancer of Nasopharynx1CTD_human
HgeneEGFRC0263454Chloracne1CTD_human
HgeneEGFRC0269102Endometrioma1CTD_human
HgeneEGFRC0279626Squamous cell carcinoma of esophagus1CGI;CTD_human
HgeneEGFRC0345905Intrahepatic Cholangiocarcinoma1CTD_human
HgeneEGFRC0345967Malignant mesothelioma1CTD_human
HgeneEGFRC0346647Malignant neoplasm of pancreas1CTD_human
HgeneEGFRC0376634Craniofacial Abnormalities1CTD_human
HgeneEGFRC0740277Bile duct carcinoma1CTD_human
HgeneEGFRC0920563Insulin Sensitivity1CTD_human
HgeneEGFRC0971858Arthritis, Collagen-Induced1CTD_human
HgeneEGFRC0993582Arthritis, Experimental1CTD_human
HgeneEGFRC1257925Mammary Carcinoma, Animal1CTD_human
HgeneEGFRC1269683Major Depressive Disorder1PSYGENET
HgeneEGFRC1449563Cardiomyopathy, Familial Idiopathic1CTD_human
HgeneEGFRC1565662Acute Kidney Insufficiency1CTD_human
HgeneEGFRC2239176Liver carcinoma1CTD_human
HgeneEGFRC2609414Acute kidney injury1CTD_human
HgeneEGFRC2713442Polyposis, Adenomatous Intestinal1CTD_human
HgeneEGFRC2713443Familial Intestinal Polyposis1CTD_human
HgeneEGFRC3805278Extrahepatic Cholangiocarcinoma1CTD_human
HgeneEGFRC4751120Neonatal inflammatory skin and bowel disease1ORPHANET
TgeneC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0026998Acute Myeloid Leukemia, M11CTD_human
TgeneC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human