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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:EGR1-DAXX (FusionGDB2 ID:HG1958TG1616) |
Fusion Gene Summary for EGR1-DAXX |
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Fusion gene information | Fusion gene name: EGR1-DAXX | Fusion gene ID: hg1958tg1616 | Hgene | Tgene | Gene symbol | EGR1 | DAXX | Gene ID | 1958 | 1616 |
Gene name | early growth response 1 | death domain associated protein | |
Synonyms | AT225|G0S30|KROX-24|NGFI-A|TIS8|ZIF-268|ZNF225 | BING2|DAP6|EAP1|SMIM40 | |
Cytomap | ('EGR1')('DAXX') 5q31.2 | 6p21.32 | |
Type of gene | protein-coding | protein-coding | |
Description | early growth response protein 1EGR-1nerve growth factor-induced protein Atranscription factor ETR103transcription factor Zif268zinc finger protein 225zinc finger protein Krox-24 | death domain-associated protein 6CENP-C binding proteinETS1-associated protein 1Fas-binding proteindeath-associated protein 6fas death domain-associated protein | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000239938, | ||
Fusion gene scores | * DoF score | 12 X 10 X 5=600 | 7 X 4 X 5=140 |
# samples | 14 | 7 | |
** MAII score | log2(14/600*10)=-2.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: EGR1 [Title/Abstract] AND DAXX [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | EGR1(137803395)-DAXX(33290149), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | EGR1 | GO:0006366 | transcription by RNA polymerase II | 19057511 |
Hgene | EGR1 | GO:0033233 | regulation of protein sumoylation | 19057511 |
Hgene | EGR1 | GO:0045893 | positive regulation of transcription, DNA-templated | 12560508 |
Hgene | EGR1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19057511 |
Hgene | EGR1 | GO:0098759 | cellular response to interleukin-8 | 20363028 |
Hgene | EGR1 | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 19307576 |
Tgene | DAXX | GO:0006334 | nucleosome assembly | 20504901|20651253 |
Tgene | DAXX | GO:0006338 | chromatin remodeling | 20651253 |
Tgene | DAXX | GO:0006355 | regulation of transcription, DNA-templated | 15878163 |
Tgene | DAXX | GO:0030521 | androgen receptor signaling pathway | 15572661 |
Tgene | DAXX | GO:0031396 | regulation of protein ubiquitination | 18566590 |
Tgene | DAXX | GO:0034605 | cellular response to heat | 15016915 |
Tgene | DAXX | GO:0034620 | cellular response to unfolded protein | 15016915 |
Tgene | DAXX | GO:0045892 | negative regulation of transcription, DNA-templated | 12140263|15572661 |
Tgene | DAXX | GO:0071276 | cellular response to cadmium ion | 15016915 |
Tgene | DAXX | GO:0071280 | cellular response to copper ion | 15016915 |
Tgene | DAXX | GO:0072738 | cellular response to diamide | 15016915 |
Tgene | DAXX | GO:1903936 | cellular response to sodium arsenite | 15016915 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for EGR1-DAXX |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for EGR1-DAXX |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for EGR1-DAXX |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:137803395/:33290149) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for EGR1-DAXX |
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Fusion Gene PPI Analysis for EGR1-DAXX |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for EGR1-DAXX |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for EGR1-DAXX |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | EGR1 | C0009171 | Cocaine Abuse | 3 | CTD_human |
Hgene | EGR1 | C0236736 | Cocaine-Related Disorders | 3 | CTD_human |
Hgene | EGR1 | C0600427 | Cocaine Dependence | 3 | CTD_human |
Hgene | EGR1 | C0008372 | Intrahepatic Cholestasis | 2 | CTD_human |
Hgene | EGR1 | C0003129 | Anoxemia | 1 | CTD_human |
Hgene | EGR1 | C0003130 | Anoxia | 1 | CTD_human |
Hgene | EGR1 | C0004364 | Autoimmune Diseases | 1 | CTD_human |
Hgene | EGR1 | C0007786 | Brain Ischemia | 1 | CTD_human |
Hgene | EGR1 | C0008311 | Cholangitis | 1 | CTD_human |
Hgene | EGR1 | C0008370 | Cholestasis | 1 | CTD_human |
Hgene | EGR1 | C0020295 | Hydronephrosis | 1 | CTD_human |
Hgene | EGR1 | C0021368 | Inflammation | 1 | CTD_human |
Hgene | EGR1 | C0022116 | Ischemia | 1 | CTD_human |
Hgene | EGR1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | EGR1 | C0025500 | Mesothelioma | 1 | CTD_human |
Hgene | EGR1 | C0032285 | Pneumonia | 1 | CTD_human |
Hgene | EGR1 | C0032300 | Lobar Pneumonia | 1 | CTD_human |
Hgene | EGR1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | EGR1 | C0035126 | Reperfusion Injury | 1 | CTD_human |
Hgene | EGR1 | C0087031 | Juvenile-Onset Still Disease | 1 | CTD_human |
Hgene | EGR1 | C0242184 | Hypoxia | 1 | CTD_human |
Hgene | EGR1 | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |
Hgene | EGR1 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
Hgene | EGR1 | C0700292 | Hypoxemia | 1 | CTD_human |
Hgene | EGR1 | C0887898 | Experimental Lung Inflammation | 1 | CTD_human |
Hgene | EGR1 | C0917798 | Cerebral Ischemia | 1 | CTD_human |
Hgene | EGR1 | C2239176 | Liver carcinoma | 1 | CTD_human |
Hgene | EGR1 | C3495559 | Juvenile arthritis | 1 | CTD_human |
Hgene | EGR1 | C3714636 | Pneumonitis | 1 | CTD_human |
Hgene | EGR1 | C3714758 | Juvenile psoriatic arthritis | 1 | CTD_human |
Hgene | EGR1 | C4552091 | Polyarthritis, Juvenile, Rheumatoid Factor Negative | 1 | CTD_human |
Hgene | EGR1 | C4704862 | Polyarthritis, Juvenile, Rheumatoid Factor Positive | 1 | CTD_human |
Tgene | C0030297 | Pancreatic Neoplasm | 1 | CTD_human | |
Tgene | C0206686 | Adrenocortical carcinoma | 1 | CTD_human | |
Tgene | C0206754 | Neuroendocrine Tumors | 1 | CTD_human | |
Tgene | C0346647 | Malignant neoplasm of pancreas | 1 | CTD_human |