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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARID2-SPATS1 (FusionGDB2 ID:HG196528TG221409)

Fusion Gene Summary for ARID2-SPATS1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARID2-SPATS1
Fusion gene ID: hg196528tg221409
HgeneTgene
Gene symbol

ARID2

SPATS1

Gene ID

196528

221409

Gene nameAT-rich interaction domain 2spermatogenesis associated serine rich 1
SynonymsBAF200|CSS6|p200DDIP|SPATA8|SRSP1
Cytomap('ARID2')('SPATS1')

12q12

6p21.1

Type of geneprotein-codingprotein-coding
DescriptionAT-rich interactive domain-containing protein 2ARID domain-containing protein 2AT rich interactive domain 2 (ARID, RFX-like)BRG1-associated factor 200zinc finger protein with activation potentialzipzap/p200spermatogenesis-associated serine-rich protein 1
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000479608, ENST00000334344, 
ENST00000444670, ENST00000457135, 
ENST00000422737, 
Fusion gene scores* DoF score17 X 9 X 12=18363 X 4 X 3=36
# samples 174
** MAII scorelog2(17/1836*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARID2 [Title/Abstract] AND SPATS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARID2(46287504)-SPATS1(44336116), # samples:2
Anticipated loss of major functional domain due to fusion event.ARID2-SPATS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID2-SPATS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID2-SPATS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID2-SPATS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID2-SPATS1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ARID2-SPATS1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ARID2-SPATS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ARID2-SPATS1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ARID2-SPATS1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
ARID2-SPATS1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARID2

GO:0006337

nucleosome disassembly

8895581

HgeneARID2

GO:0008285

negative regulation of cell proliferation

26169693

HgeneARID2

GO:0030336

negative regulation of cell migration

26169693


check buttonFusion gene breakpoints across ARID2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SPATS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-E7-A7DV-01AARID2chr12

46287504

-SPATS1chr6

44336116

+
ChimerDB4BLCATCGA-E7-A7DV-01AARID2chr12

46287504

+SPATS1chr6

44336116

+


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Fusion Gene ORF analysis for ARID2-SPATS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000479608ENST00000288390ARID2chr12

46287504

+SPATS1chr6

44336116

+
3UTR-3CDSENST00000479608ENST00000323108ARID2chr12

46287504

+SPATS1chr6

44336116

+
Frame-shiftENST00000334344ENST00000288390ARID2chr12

46287504

+SPATS1chr6

44336116

+
Frame-shiftENST00000334344ENST00000323108ARID2chr12

46287504

+SPATS1chr6

44336116

+
Frame-shiftENST00000444670ENST00000288390ARID2chr12

46287504

+SPATS1chr6

44336116

+
Frame-shiftENST00000444670ENST00000323108ARID2chr12

46287504

+SPATS1chr6

44336116

+
Frame-shiftENST00000457135ENST00000288390ARID2chr12

46287504

+SPATS1chr6

44336116

+
Frame-shiftENST00000457135ENST00000323108ARID2chr12

46287504

+SPATS1chr6

44336116

+
In-frameENST00000422737ENST00000288390ARID2chr12

46287504

+SPATS1chr6

44336116

+
In-frameENST00000422737ENST00000323108ARID2chr12

46287504

+SPATS1chr6

44336116

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000422737ARID2chr1246287504+ENST00000323108SPATS1chr644336116+582153895353531766
ENST00000422737ARID2chr1246287504+ENST00000288390SPATS1chr644336116+582253895353531766

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000422737ENST00000323108ARID2chr1246287504+SPATS1chr644336116+0.0008161170.99918383
ENST00000422737ENST00000288390ARID2chr1246287504+SPATS1chr644336116+0.0008112470.9991887

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Fusion Genomic Features for ARID2-SPATS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARID2chr1246287504+SPATS1chr644336115+0.0002318940.9997681
ARID2chr1246287504+SPATS1chr644336115+0.0002318940.9997681

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARID2-SPATS1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:46287504/chr6:44336116)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID2chr12:46287504chr6:44336116ENST00000334344+2021793_112817871836.0Compositional biasNote=Gln-rich
HgeneARID2chr12:46287504chr6:44336116ENST00000334344+2021524_60317871836.0DNA bindingRFX-type winged-helix
HgeneARID2chr12:46287504chr6:44336116ENST00000334344+202113_10517871836.0DomainARID
HgeneARID2chr12:46287504chr6:44336116ENST00000334344+2021313_31717871836.0MotifNote=LXXLL
HgeneARID2chr12:46287504chr6:44336116ENST00000334344+20211632_165717871836.0Zinc fingerNote=C2H2-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPATS1chr12:46287504chr6:44336116ENST000002883903869_75191301.0Compositional biasNote=Poly-Ser
TgeneSPATS1chr12:46287504chr6:44336116ENST000003231084969_75191301.0Compositional biasNote=Poly-Ser


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Fusion Gene Sequence for ARID2-SPATS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6442_6442_1_ARID2-SPATS1_ARID2_chr12_46287504_ENST00000422737_SPATS1_chr6_44336116_ENST00000288390_length(transcript)=5822nt_BP=5389nt
ACCACAGCAGAGGGTCGCCTTTTAAAAAAATCCCTGCGGTGGGTGGGAAGGAGCTGGATCTTCACGGTCTCTACACCAGAGTCACTACTT
TAGGCGGATTCGCGAAGGTTTCTGAGAAGAATCAGTGGGGAGAAATTGTTGAAGAGTTCAACTTTCCCAGAAGTTGTTCTAACGCTGCCT
TTGCTTTAAAACAGTATTACTTGCGTTACCTAGAAAAGTACGAGAAAGTTCATCATTTTGGGGAGGATGATGATGAGGTACCACCAGGCA
ATCCAAAGCCACAGCTTCCTATTGGTGCAATTCCATCTTCCTACAATTACCAGCAACACAGTGTGTCGGATTATCTGCGTCAAAGTTATG
GGCTGTCCATGGACTTTAATTCGCCAAATGATTATAATAAATTGGTGCTTTCACTGTTATCTGGACTCCCAAATGAAGTGGACTTTGCTA
TTAACGTATGCACTCTCCTATCAAATGAAAGCAAGCACGTCATGCAACTTGAAAAAGATCCTAAAATCATCACTTTACTACTTGCTAATG
CCGGGGTGTTTGACGACACTTTAGGATCCTTTTCCACTGTATTTGGAGAAGAATGGAAAGAGAAGACTGATAGAGACTTCGTTAAGTTTT
GGAAAGACATCGTTGATGATAATGAAGTTCGTGACCTCATTTCTGACAGAAACAAGTCTCATGAAGGTACATCAGGAGAATGGATTTGGG
AGTCTTTATTTCATCCACCTCGAAAGCTGGGCATTAACGATATTGAAGGACAGCGGGTACTTCAGATTGCAGTGATTTTGAGAAATCTTT
CCTTTGAGGAGGGCAATGTTAAGCTCTTGGCAGCTAATCGTACCTGTCTTCGTTTCCTATTACTTTCTGCACATAGTCATTTTATTTCTT
TAAGGCAATTAGGCCTTGACACATTAGGAAATATTGCAGCTGAGCTTTTACTGGACCCTGTTGATTTCAAAACTACTCATCTGATGTTTC
ATACTGTTACAAAATGTCTAATGTCAAGGGATAGATTTTTAAAGATGAGAGGCATGGAAATTTTGGGAAATCTTTGCAAAGCAGAAGATA
ATGGTGTTTTAATTTGTGAATATGTGGATCAGGATTCCTACAGAGAGATCATTTGTCATCTCACTTTACCTGATGTGCTGCTTGTAATCT
CAACACTCGAGGTGCTATACATGCTCACGGAAATGGGAGATGTTGCTTGCACAAAAATTGCAAAAGTAGAAAAGAGCATAGACATGTTAG
TGTGTCTGGTTTCTATGGATATTCAGATGTTTGGCCCTGATGCACTAGCTGCGGTAAAACTCATTGAACACCCAAGTTCCAGTCATCAAA
TGTTATCTGAAATTAGGCCACAAGCTATAGAGCAAGTCCAAACCCAGACTCATGTAGCATCTGCCCCAGCTTCCAGAGCAGTTGTAGCGC
AGCATGTTGCTCCACCTCCAGGAATAGTGGAAATAGATAGTGAGAAGTTTGCTTGTCAGTGGCTAAATGCTCATTTTGAAGTAAATCCAG
ATTGTTCTGTTTCTCGAGCAGAAATGTATTCTGAATACCTCTCGACTTGCAGTAAATTAGCTCGTGGTGGAATCCTAACATCAACTGGAT
TTTATAAATGTCTTAGAACGGTCTTTCCAAATCATACAGTGAAGAGAGTGGAGGATTCCAGTAGCAATGGGCAGGCACATATTCATGTGG
TAGGAGTAAAACGGAGGGCTATACCACTTCCCATTCAGATGTACTATCAGCAGCAACCAGTTTCTACTTCTGTTGTTCGTGTTGATTCTG
TTCCTGATGTATCTCCTGCTCCTTCACCTGCAGGAATCCCTCATGGATCACAAACCATAGGAAACCATTTTCAGAGGACTCCTGTTGCCA
ACCAATCTTCAAATCTGACTGCAACACAAATGTCTTTTCCTGTACAAGGTGTTCATACTGTGGCACAAACTGTTTCAAGAATTCCACAAA
ATCCTTCACCTCATACCCACCAGCAACAAAATGCTCCAGTGACTGTCATTCAAAGTAAAGCTCCAATTCCTTGTGAAGTTGTTAAGGCTA
CAGTTATCCAGAATTCCATACCCCAGACAGGAGTTCCTGTTAGTATTGCTGTTGGAGGAGGACCTCCACAGAGTTCTGTTGTTCAGAATC
ATAGTACAGGGCCACAACCTGTTACAGTTGTGAATTCTCAGACATTGCTTCACCATCCATCTGTAATTCCACAGCAGTCTCCATTACACA
CAGTGGTACCAGGACAGATCCCTTCAGGCACTCCTGTTACAGTAATTCAACAAGCTGTCCCACAGAGTCATATGTTTGGCAGAGTACAGA
ACATACCAGCATGTACTTCTACAGTTTCACAGGGTCAACAGTTAATCACCACATCACCCCAACCTGTGCAAACTTCATCTCAACAGACAT
CAGCTGGTAGCCAGTCACAAGATACTGTTATCATAGCACCCCCACAGTATGTAACAACTTCTGCATCCAATATTGTCTCAGCAACTTCAG
TACAGAATTTTCAGGTAGCTACAGGACAAATGGTTACTATTGCTGGTGTCCCAAGTCCACAAGCCTCAAGGGTAGGGTTTCAGAACATTG
CACCAAAACCTCTCCCTTCTCAGCAAGTTTCATCTACAGTGGTACAGCAGCCTATTCAACAACCACAGCAGCCAACCCAACAAAGCGTAG
TGATTGTAAGCCAGCCAGCTCAACAAGGTCAAACTTATGCACCAGCCATTCACCAAATTGTTCTTGCTAATCCAGCAGCTCTTCCAGCTG
GTCAGACAGTTCAGCTAACTGGACAACCTAACATAACTCCATCTTCTTCACCATCACCTGTCCCAGCTACTAATAACCAAGTCCCTACTG
CCATGTCGTCGTCCTCTACCCCTCAATCACAGGGACCACCTCCTACTGTCAGTCAAATGTTATCTGTGAAAAGGCAGCAACAGCAGCAAC
ATTCACCAGCACCCCCACCACAGCAGGTACAAGTACAAGTTCAGCAGCCCCAACAAGTACAGATGCAAGTTCAACCTCAACAGTCGAATG
CAGGAGTTGGTCAGCCTGCCTCTGGTGAGTCGAGTCTGATTAAACAGCTTCTGCTTCCGAAACGTGGTCCTTCAACACCAGGTGGTAAGC
TTATTCTCCCAGCTCCACAGATTCCTCCCCCTAATAATGCAAGAGCTCCTAGCCCTCAGGTGGTCTATCAGGTGGCCAGTAACCAAGCCG
CAGGTTTTGGAGTGCAGGGGCAAACTCCAGCTCAGCAGCTATTGGTTGGGCAGCAAAATGTTCAGTTGGTCCCAAGTGCAATGCCACCCT
CAGGGGGAGTACAAACTGTGCCCATTTCGAACTTACAAATATTGCCAGGTCCACTGATCTCAAATAGCCCAGCAACCATTTTCCAAGGGA
CTTCTGGCAACCAGGTAACCATAACAGTTGTGCCAAATACGAGTTTTGCACCTGCAACTGTGAGTCAGGGAAATGCAACTCAGCTCATTG
CTCCAGCAGGAATTACCATGAGCGGAACGCAGACAGGAGTTGGACTTCCAGTACAAACGCTTCCAGCCACTCAAGCATCTCCTGCTGGAC
AATCATCATGTACTACTGCTACTCCCCCATTCAAAGGTGATAAAATAATTTGCCAAAAGGAGGAGGAAGCAAAGGAAGCAACAGGTTTAC
ATGTTCATGAACGTAAAATTGAAGTCATGGAGAACCCGTCCTGCCGACGAGGAGCCACAAACACCAGCAATGGGGATACAAAGGAAAATG
AAATGCATGTGGGAAGTCTTTTAAATGGGAGAAAGTACAGTGACTCAAGTCTACCTCCTTCAAACTCAGGGAAAATTCAAAGTGAGACTA
ATCAGTGCTCACTAATCAGTAATGGGCCATCATTGGAATTAGGTGAGAATGGAGCATCTGGGAAACAGAACTCAGAACAAATAGACATGC
AAGATATCAAAAGTGATTTGAGAAAACCGCTAGTTAATGGAATCTGTGATTTTGATAAAGGAGATGGTTCTCATTTAAGCAAAAACATTC
CAAATCATAAAACTTCCAATCATGTAGGAAATGGTGAGATATCTCCAATGGAACCACAAGGGACTTTAGATATCACTCAGCAAGATACTG
CCAAAGGTGATCAACTAGAAAGAATTTCTAATGGACCTGTATTAACTTTGGGTGGTTCATCTGTGAGCAGTATACAGGAGGCTTCAAATG
CGGCAACACAGCAATTTAGTGGTACTGATTTGCTTAATGGACCTCTAGCTTCAAGTTTGAATTCAGATGTGCCTCAGCAACGCCCAAGTG
TAGTTGTCTCACCACATTCTACAACCTCTGTTATACAGGGACATCAAATCATAGCAGTTCCCGACTCAGGATCAAAAGTATCCCATTCTC
CTGCCCTATCATCTGACGTTCGGTCTACAAATGGCACAGCAGAATGCAAAACTGTAAAGAGGCCAGCAGAGGATACTGATAGGGAAACAG
TCGCAGGAATTCCAAATAAAGTAGGAGTTAGAATTGTTACAATCAGTGACCCCAACAATGCTGGCTGCAGCGCAACAATGGTTGCTGTGC
CAGCAGGAGCAGATCCAAGCACTGTAGCTAAAGTAGCAATAGAAAGTGCTGTTCAGCAAAAGCAACAGCATCCACCAACATATGTACAGA
ATGTGGTCCCGCAGAACACTCCTATGCCACCTTCACCAGCTGTACAAGTGCAGGGCCAGCCTAACAGTTCTCAGCCTTCTCCATTCAGTG
GATCCAGTCAGCCTGGAGATCCAATGAGAAAACCTGGACAGAACTTCATGTGTCTGTGGCAGTCTTGTAAAAAGTGGTTTCAGACACCCT
CACAGGTTTTCTACCATGCAGCAACTGAACATGGAGGAAAAGATGTATATCCAGGGCAGTGTCTTTGGGAAGGTTGTGAGCCTTTTCAGC
GACAGCGGTTTTCTTTTATTACCCACTTGCAGGATAAGCACTGTTCAAAGGATGCCCTACTTGCAGGATTAAAACAAGATGAACCAGGAC
AAGCAGGAAGTCAGAAGTCTTCTACCAAGCAGCCAACTGTAGGGGGCACAAGCTCAACTCCTAGAGCACAAAAGGCCATTGTGAATCATC
CCAGTGCTGCACTTATGGCTCTGAGGAGAGGATCAAGAAACCTTGTCTTTCGAGATTTTACAGTGAGTAATATGTTTTCTGTAGCCAAAG
TGAATTTAGTTTATTTTATTTTTACATATAAGTTAATAAAATTAGATAACTGTATTTTCTTCATTGTTTTTCTCATCAATTTTGCAAATA
CATCCAAAAGTTTATGCCTAGGTCAGGCCATGATGAGCTCTTAAAAGTCAAAAATAAATAGAAGTTAAAACAACCAAAAATATTGATCCC
AGGAATGGAATCCCAAAGTTAACTCCAGGCGACAATCCATATATGTACCCAGAACAGAGTAAAGGCTTCCACAAAGCAGGATCAATGCTC
CCACCAGTGAATTTTTCAATAGTGCCTTATGAAAAGAAATTTGATACATTTATTCCACTTGAGCCTCTTCCACAAATTCCCAACTTGCCT
TTCTGGGTGAAGGAGAAGGCCAACAGTTTGAAAAATGAGATACAAGAGGTTGAGGAGCTTGACAACTGGCAGCCAGCAGTGCCCTTAATG
CACATGCTACACCTTTCTGGTGCTTTGGACTTTCCAAGACAATCCTGAGCATAAACAGGCCCACAAAACATGTGCTGACTGCACTCTGGC

>6442_6442_1_ARID2-SPATS1_ARID2_chr12_46287504_ENST00000422737_SPATS1_chr6_44336116_ENST00000288390_length(amino acids)=1766AA_BP=
MDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFPRSCSNAAFALKQYYLRYLEKYEKVHHFGEDDDEVPPGNPKPQLPIGAIPSSYNYQ
QHSVSDYLRQSYGLSMDFNSPNDYNKLVLSLLSGLPNEVDFAINVCTLLSNESKHVMQLEKDPKIITLLLANAGVFDDTLGSFSTVFGEE
WKEKTDRDFVKFWKDIVDDNEVRDLISDRNKSHEGTSGEWIWESLFHPPRKLGINDIEGQRVLQIAVILRNLSFEEGNVKLLAANRTCLR
FLLLSAHSHFISLRQLGLDTLGNIAAELLLDPVDFKTTHLMFHTVTKCLMSRDRFLKMRGMEILGNLCKAEDNGVLICEYVDQDSYREII
CHLTLPDVLLVISTLEVLYMLTEMGDVACTKIAKVEKSIDMLVCLVSMDIQMFGPDALAAVKLIEHPSSSHQMLSEIRPQAIEQVQTQTH
VASAPASRAVVAQHVAPPPGIVEIDSEKFACQWLNAHFEVNPDCSVSRAEMYSEYLSTCSKLARGGILTSTGFYKCLRTVFPNHTVKRVE
DSSSNGQAHIHVVGVKRRAIPLPIQMYYQQQPVSTSVVRVDSVPDVSPAPSPAGIPHGSQTIGNHFQRTPVANQSSNLTATQMSFPVQGV
HTVAQTVSRIPQNPSPHTHQQQNAPVTVIQSKAPIPCEVVKATVIQNSIPQTGVPVSIAVGGGPPQSSVVQNHSTGPQPVTVVNSQTLLH
HPSVIPQQSPLHTVVPGQIPSGTPVTVIQQAVPQSHMFGRVQNIPACTSTVSQGQQLITTSPQPVQTSSQQTSAGSQSQDTVIIAPPQYV
TTSASNIVSATSVQNFQVATGQMVTIAGVPSPQASRVGFQNIAPKPLPSQQVSSTVVQQPIQQPQQPTQQSVVIVSQPAQQGQTYAPAIH
QIVLANPAALPAGQTVQLTGQPNITPSSSPSPVPATNNQVPTAMSSSSTPQSQGPPPTVSQMLSVKRQQQQQHSPAPPPQQVQVQVQQPQ
QVQMQVQPQQSNAGVGQPASGESSLIKQLLLPKRGPSTPGGKLILPAPQIPPPNNARAPSPQVVYQVASNQAAGFGVQGQTPAQQLLVGQ
QNVQLVPSAMPPSGGVQTVPISNLQILPGPLISNSPATIFQGTSGNQVTITVVPNTSFAPATVSQGNATQLIAPAGITMSGTQTGVGLPV
QTLPATQASPAGQSSCTTATPPFKGDKIICQKEEEAKEATGLHVHERKIEVMENPSCRRGATNTSNGDTKENEMHVGSLLNGRKYSDSSL
PPSNSGKIQSETNQCSLISNGPSLELGENGASGKQNSEQIDMQDIKSDLRKPLVNGICDFDKGDGSHLSKNIPNHKTSNHVGNGEISPME
PQGTLDITQQDTAKGDQLERISNGPVLTLGGSSVSSIQEASNAATQQFSGTDLLNGPLASSLNSDVPQQRPSVVVSPHSTTSVIQGHQII
AVPDSGSKVSHSPALSSDVRSTNGTAECKTVKRPAEDTDRETVAGIPNKVGVRIVTISDPNNAGCSATMVAVPAGADPSTVAKVAIESAV
QQKQQHPPTYVQNVVPQNTPMPPSPAVQVQGQPNSSQPSPFSGSSQPGDPMRKPGQNFMCLWQSCKKWFQTPSQVFYHAATEHGGKDVYP
GQCLWEGCEPFQRQRFSFITHLQDKHCSKDALLAGLKQDEPGQAGSQKSSTKQPTVGGTSSTPRAQKAIVNHPSAALMALRRGSRNLVFR

--------------------------------------------------------------
>6442_6442_2_ARID2-SPATS1_ARID2_chr12_46287504_ENST00000422737_SPATS1_chr6_44336116_ENST00000323108_length(transcript)=5821nt_BP=5389nt
ACCACAGCAGAGGGTCGCCTTTTAAAAAAATCCCTGCGGTGGGTGGGAAGGAGCTGGATCTTCACGGTCTCTACACCAGAGTCACTACTT
TAGGCGGATTCGCGAAGGTTTCTGAGAAGAATCAGTGGGGAGAAATTGTTGAAGAGTTCAACTTTCCCAGAAGTTGTTCTAACGCTGCCT
TTGCTTTAAAACAGTATTACTTGCGTTACCTAGAAAAGTACGAGAAAGTTCATCATTTTGGGGAGGATGATGATGAGGTACCACCAGGCA
ATCCAAAGCCACAGCTTCCTATTGGTGCAATTCCATCTTCCTACAATTACCAGCAACACAGTGTGTCGGATTATCTGCGTCAAAGTTATG
GGCTGTCCATGGACTTTAATTCGCCAAATGATTATAATAAATTGGTGCTTTCACTGTTATCTGGACTCCCAAATGAAGTGGACTTTGCTA
TTAACGTATGCACTCTCCTATCAAATGAAAGCAAGCACGTCATGCAACTTGAAAAAGATCCTAAAATCATCACTTTACTACTTGCTAATG
CCGGGGTGTTTGACGACACTTTAGGATCCTTTTCCACTGTATTTGGAGAAGAATGGAAAGAGAAGACTGATAGAGACTTCGTTAAGTTTT
GGAAAGACATCGTTGATGATAATGAAGTTCGTGACCTCATTTCTGACAGAAACAAGTCTCATGAAGGTACATCAGGAGAATGGATTTGGG
AGTCTTTATTTCATCCACCTCGAAAGCTGGGCATTAACGATATTGAAGGACAGCGGGTACTTCAGATTGCAGTGATTTTGAGAAATCTTT
CCTTTGAGGAGGGCAATGTTAAGCTCTTGGCAGCTAATCGTACCTGTCTTCGTTTCCTATTACTTTCTGCACATAGTCATTTTATTTCTT
TAAGGCAATTAGGCCTTGACACATTAGGAAATATTGCAGCTGAGCTTTTACTGGACCCTGTTGATTTCAAAACTACTCATCTGATGTTTC
ATACTGTTACAAAATGTCTAATGTCAAGGGATAGATTTTTAAAGATGAGAGGCATGGAAATTTTGGGAAATCTTTGCAAAGCAGAAGATA
ATGGTGTTTTAATTTGTGAATATGTGGATCAGGATTCCTACAGAGAGATCATTTGTCATCTCACTTTACCTGATGTGCTGCTTGTAATCT
CAACACTCGAGGTGCTATACATGCTCACGGAAATGGGAGATGTTGCTTGCACAAAAATTGCAAAAGTAGAAAAGAGCATAGACATGTTAG
TGTGTCTGGTTTCTATGGATATTCAGATGTTTGGCCCTGATGCACTAGCTGCGGTAAAACTCATTGAACACCCAAGTTCCAGTCATCAAA
TGTTATCTGAAATTAGGCCACAAGCTATAGAGCAAGTCCAAACCCAGACTCATGTAGCATCTGCCCCAGCTTCCAGAGCAGTTGTAGCGC
AGCATGTTGCTCCACCTCCAGGAATAGTGGAAATAGATAGTGAGAAGTTTGCTTGTCAGTGGCTAAATGCTCATTTTGAAGTAAATCCAG
ATTGTTCTGTTTCTCGAGCAGAAATGTATTCTGAATACCTCTCGACTTGCAGTAAATTAGCTCGTGGTGGAATCCTAACATCAACTGGAT
TTTATAAATGTCTTAGAACGGTCTTTCCAAATCATACAGTGAAGAGAGTGGAGGATTCCAGTAGCAATGGGCAGGCACATATTCATGTGG
TAGGAGTAAAACGGAGGGCTATACCACTTCCCATTCAGATGTACTATCAGCAGCAACCAGTTTCTACTTCTGTTGTTCGTGTTGATTCTG
TTCCTGATGTATCTCCTGCTCCTTCACCTGCAGGAATCCCTCATGGATCACAAACCATAGGAAACCATTTTCAGAGGACTCCTGTTGCCA
ACCAATCTTCAAATCTGACTGCAACACAAATGTCTTTTCCTGTACAAGGTGTTCATACTGTGGCACAAACTGTTTCAAGAATTCCACAAA
ATCCTTCACCTCATACCCACCAGCAACAAAATGCTCCAGTGACTGTCATTCAAAGTAAAGCTCCAATTCCTTGTGAAGTTGTTAAGGCTA
CAGTTATCCAGAATTCCATACCCCAGACAGGAGTTCCTGTTAGTATTGCTGTTGGAGGAGGACCTCCACAGAGTTCTGTTGTTCAGAATC
ATAGTACAGGGCCACAACCTGTTACAGTTGTGAATTCTCAGACATTGCTTCACCATCCATCTGTAATTCCACAGCAGTCTCCATTACACA
CAGTGGTACCAGGACAGATCCCTTCAGGCACTCCTGTTACAGTAATTCAACAAGCTGTCCCACAGAGTCATATGTTTGGCAGAGTACAGA
ACATACCAGCATGTACTTCTACAGTTTCACAGGGTCAACAGTTAATCACCACATCACCCCAACCTGTGCAAACTTCATCTCAACAGACAT
CAGCTGGTAGCCAGTCACAAGATACTGTTATCATAGCACCCCCACAGTATGTAACAACTTCTGCATCCAATATTGTCTCAGCAACTTCAG
TACAGAATTTTCAGGTAGCTACAGGACAAATGGTTACTATTGCTGGTGTCCCAAGTCCACAAGCCTCAAGGGTAGGGTTTCAGAACATTG
CACCAAAACCTCTCCCTTCTCAGCAAGTTTCATCTACAGTGGTACAGCAGCCTATTCAACAACCACAGCAGCCAACCCAACAAAGCGTAG
TGATTGTAAGCCAGCCAGCTCAACAAGGTCAAACTTATGCACCAGCCATTCACCAAATTGTTCTTGCTAATCCAGCAGCTCTTCCAGCTG
GTCAGACAGTTCAGCTAACTGGACAACCTAACATAACTCCATCTTCTTCACCATCACCTGTCCCAGCTACTAATAACCAAGTCCCTACTG
CCATGTCGTCGTCCTCTACCCCTCAATCACAGGGACCACCTCCTACTGTCAGTCAAATGTTATCTGTGAAAAGGCAGCAACAGCAGCAAC
ATTCACCAGCACCCCCACCACAGCAGGTACAAGTACAAGTTCAGCAGCCCCAACAAGTACAGATGCAAGTTCAACCTCAACAGTCGAATG
CAGGAGTTGGTCAGCCTGCCTCTGGTGAGTCGAGTCTGATTAAACAGCTTCTGCTTCCGAAACGTGGTCCTTCAACACCAGGTGGTAAGC
TTATTCTCCCAGCTCCACAGATTCCTCCCCCTAATAATGCAAGAGCTCCTAGCCCTCAGGTGGTCTATCAGGTGGCCAGTAACCAAGCCG
CAGGTTTTGGAGTGCAGGGGCAAACTCCAGCTCAGCAGCTATTGGTTGGGCAGCAAAATGTTCAGTTGGTCCCAAGTGCAATGCCACCCT
CAGGGGGAGTACAAACTGTGCCCATTTCGAACTTACAAATATTGCCAGGTCCACTGATCTCAAATAGCCCAGCAACCATTTTCCAAGGGA
CTTCTGGCAACCAGGTAACCATAACAGTTGTGCCAAATACGAGTTTTGCACCTGCAACTGTGAGTCAGGGAAATGCAACTCAGCTCATTG
CTCCAGCAGGAATTACCATGAGCGGAACGCAGACAGGAGTTGGACTTCCAGTACAAACGCTTCCAGCCACTCAAGCATCTCCTGCTGGAC
AATCATCATGTACTACTGCTACTCCCCCATTCAAAGGTGATAAAATAATTTGCCAAAAGGAGGAGGAAGCAAAGGAAGCAACAGGTTTAC
ATGTTCATGAACGTAAAATTGAAGTCATGGAGAACCCGTCCTGCCGACGAGGAGCCACAAACACCAGCAATGGGGATACAAAGGAAAATG
AAATGCATGTGGGAAGTCTTTTAAATGGGAGAAAGTACAGTGACTCAAGTCTACCTCCTTCAAACTCAGGGAAAATTCAAAGTGAGACTA
ATCAGTGCTCACTAATCAGTAATGGGCCATCATTGGAATTAGGTGAGAATGGAGCATCTGGGAAACAGAACTCAGAACAAATAGACATGC
AAGATATCAAAAGTGATTTGAGAAAACCGCTAGTTAATGGAATCTGTGATTTTGATAAAGGAGATGGTTCTCATTTAAGCAAAAACATTC
CAAATCATAAAACTTCCAATCATGTAGGAAATGGTGAGATATCTCCAATGGAACCACAAGGGACTTTAGATATCACTCAGCAAGATACTG
CCAAAGGTGATCAACTAGAAAGAATTTCTAATGGACCTGTATTAACTTTGGGTGGTTCATCTGTGAGCAGTATACAGGAGGCTTCAAATG
CGGCAACACAGCAATTTAGTGGTACTGATTTGCTTAATGGACCTCTAGCTTCAAGTTTGAATTCAGATGTGCCTCAGCAACGCCCAAGTG
TAGTTGTCTCACCACATTCTACAACCTCTGTTATACAGGGACATCAAATCATAGCAGTTCCCGACTCAGGATCAAAAGTATCCCATTCTC
CTGCCCTATCATCTGACGTTCGGTCTACAAATGGCACAGCAGAATGCAAAACTGTAAAGAGGCCAGCAGAGGATACTGATAGGGAAACAG
TCGCAGGAATTCCAAATAAAGTAGGAGTTAGAATTGTTACAATCAGTGACCCCAACAATGCTGGCTGCAGCGCAACAATGGTTGCTGTGC
CAGCAGGAGCAGATCCAAGCACTGTAGCTAAAGTAGCAATAGAAAGTGCTGTTCAGCAAAAGCAACAGCATCCACCAACATATGTACAGA
ATGTGGTCCCGCAGAACACTCCTATGCCACCTTCACCAGCTGTACAAGTGCAGGGCCAGCCTAACAGTTCTCAGCCTTCTCCATTCAGTG
GATCCAGTCAGCCTGGAGATCCAATGAGAAAACCTGGACAGAACTTCATGTGTCTGTGGCAGTCTTGTAAAAAGTGGTTTCAGACACCCT
CACAGGTTTTCTACCATGCAGCAACTGAACATGGAGGAAAAGATGTATATCCAGGGCAGTGTCTTTGGGAAGGTTGTGAGCCTTTTCAGC
GACAGCGGTTTTCTTTTATTACCCACTTGCAGGATAAGCACTGTTCAAAGGATGCCCTACTTGCAGGATTAAAACAAGATGAACCAGGAC
AAGCAGGAAGTCAGAAGTCTTCTACCAAGCAGCCAACTGTAGGGGGCACAAGCTCAACTCCTAGAGCACAAAAGGCCATTGTGAATCATC
CCAGTGCTGCACTTATGGCTCTGAGGAGAGGATCAAGAAACCTTGTCTTTCGAGATTTTACAGTGAGTAATATGTTTTCTGTAGCCAAAG
TGAATTTAGTTTATTTTATTTTTACATATAAGTTAATAAAATTAGATAACTGTATTTTCTTCATTGTTTTTCTCATCAATTTTGCAAATA
CATCCAAAAGTTTATGCCTAGGTCAGGCCATGATGAGCTCTTAAAAGTCAAAAATAAATAGAAGTTAAAACAACCAAAAATATTGATCCC
AGGAATGGAATCCCAAAGTTAACTCCAGGCGACAATCCATATATGTACCCAGAACAGAGTAAAGGCTTCCACAAAGCAGGATCAATGCTC
CCACCAGTGAATTTTTCAATAGTGCCTTATGAAAAGAAATTTGATACATTTATTCCACTTGAGCCTCTTCCACAAATTCCCAACTTGCCT
TTCTGGGTGAAGGAGAAGGCCAACAGTTTGAAAAATGAGATACAAGAGGTTGAGGAGCTTGACAACTGGCAGCCAGCAGTGCCCTTAATG
CACATGCTACACCTTTCTGGTGCTTTGGACTTTCCAAGACAATCCTGAGCATAAACAGGCCCACAAAACATGTGCTGACTGCACTCTGGC

>6442_6442_2_ARID2-SPATS1_ARID2_chr12_46287504_ENST00000422737_SPATS1_chr6_44336116_ENST00000323108_length(amino acids)=1766AA_BP=
MDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFPRSCSNAAFALKQYYLRYLEKYEKVHHFGEDDDEVPPGNPKPQLPIGAIPSSYNYQ
QHSVSDYLRQSYGLSMDFNSPNDYNKLVLSLLSGLPNEVDFAINVCTLLSNESKHVMQLEKDPKIITLLLANAGVFDDTLGSFSTVFGEE
WKEKTDRDFVKFWKDIVDDNEVRDLISDRNKSHEGTSGEWIWESLFHPPRKLGINDIEGQRVLQIAVILRNLSFEEGNVKLLAANRTCLR
FLLLSAHSHFISLRQLGLDTLGNIAAELLLDPVDFKTTHLMFHTVTKCLMSRDRFLKMRGMEILGNLCKAEDNGVLICEYVDQDSYREII
CHLTLPDVLLVISTLEVLYMLTEMGDVACTKIAKVEKSIDMLVCLVSMDIQMFGPDALAAVKLIEHPSSSHQMLSEIRPQAIEQVQTQTH
VASAPASRAVVAQHVAPPPGIVEIDSEKFACQWLNAHFEVNPDCSVSRAEMYSEYLSTCSKLARGGILTSTGFYKCLRTVFPNHTVKRVE
DSSSNGQAHIHVVGVKRRAIPLPIQMYYQQQPVSTSVVRVDSVPDVSPAPSPAGIPHGSQTIGNHFQRTPVANQSSNLTATQMSFPVQGV
HTVAQTVSRIPQNPSPHTHQQQNAPVTVIQSKAPIPCEVVKATVIQNSIPQTGVPVSIAVGGGPPQSSVVQNHSTGPQPVTVVNSQTLLH
HPSVIPQQSPLHTVVPGQIPSGTPVTVIQQAVPQSHMFGRVQNIPACTSTVSQGQQLITTSPQPVQTSSQQTSAGSQSQDTVIIAPPQYV
TTSASNIVSATSVQNFQVATGQMVTIAGVPSPQASRVGFQNIAPKPLPSQQVSSTVVQQPIQQPQQPTQQSVVIVSQPAQQGQTYAPAIH
QIVLANPAALPAGQTVQLTGQPNITPSSSPSPVPATNNQVPTAMSSSSTPQSQGPPPTVSQMLSVKRQQQQQHSPAPPPQQVQVQVQQPQ
QVQMQVQPQQSNAGVGQPASGESSLIKQLLLPKRGPSTPGGKLILPAPQIPPPNNARAPSPQVVYQVASNQAAGFGVQGQTPAQQLLVGQ
QNVQLVPSAMPPSGGVQTVPISNLQILPGPLISNSPATIFQGTSGNQVTITVVPNTSFAPATVSQGNATQLIAPAGITMSGTQTGVGLPV
QTLPATQASPAGQSSCTTATPPFKGDKIICQKEEEAKEATGLHVHERKIEVMENPSCRRGATNTSNGDTKENEMHVGSLLNGRKYSDSSL
PPSNSGKIQSETNQCSLISNGPSLELGENGASGKQNSEQIDMQDIKSDLRKPLVNGICDFDKGDGSHLSKNIPNHKTSNHVGNGEISPME
PQGTLDITQQDTAKGDQLERISNGPVLTLGGSSVSSIQEASNAATQQFSGTDLLNGPLASSLNSDVPQQRPSVVVSPHSTTSVIQGHQII
AVPDSGSKVSHSPALSSDVRSTNGTAECKTVKRPAEDTDRETVAGIPNKVGVRIVTISDPNNAGCSATMVAVPAGADPSTVAKVAIESAV
QQKQQHPPTYVQNVVPQNTPMPPSPAVQVQGQPNSSQPSPFSGSSQPGDPMRKPGQNFMCLWQSCKKWFQTPSQVFYHAATEHGGKDVYP
GQCLWEGCEPFQRQRFSFITHLQDKHCSKDALLAGLKQDEPGQAGSQKSSTKQPTVGGTSSTPRAQKAIVNHPSAALMALRRGSRNLVFR

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Fusion Gene PPI Analysis for ARID2-SPATS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARID2-SPATS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARID2-SPATS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARID2C2239176Liver carcinoma2CGI;CTD_human
HgeneARID2C0033578Prostatic Neoplasms1CTD_human
HgeneARID2C0265338Coffin-Siris syndrome1ORPHANET
HgeneARID2C0376358Malignant neoplasm of prostate1CTD_human