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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ARID2-TMPRSS2 (FusionGDB2 ID:HG196528TG7113) |
Fusion Gene Summary for ARID2-TMPRSS2 |
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Fusion gene information | Fusion gene name: ARID2-TMPRSS2 | Fusion gene ID: hg196528tg7113 | Hgene | Tgene | Gene symbol | ARID2 | TMPRSS2 | Gene ID | 196528 | 7113 |
Gene name | AT-rich interaction domain 2 | transmembrane serine protease 2 | |
Synonyms | BAF200|CSS6|p200 | PP9284|PRSS10 | |
Cytomap | ('ARID2')('TMPRSS2') 12q12 | 21q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | AT-rich interactive domain-containing protein 2ARID domain-containing protein 2AT rich interactive domain 2 (ARID, RFX-like)BRG1-associated factor 200zinc finger protein with activation potentialzipzap/p200 | transmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2 | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | . | O15393 | |
Ensembl transtripts involved in fusion gene | ENST00000479608, ENST00000334344, ENST00000422737, ENST00000444670, ENST00000457135, | ||
Fusion gene scores | * DoF score | 17 X 9 X 12=1836 | 28 X 34 X 5=4760 |
# samples | 17 | 35 | |
** MAII score | log2(17/1836*10)=-3.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(35/4760*10)=-3.76553474636298 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ARID2 [Title/Abstract] AND TMPRSS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ARID2(46233279)-TMPRSS2(42902141), # samples:1 ARID2(46233279)-TMPRSS2(42902145), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ARID2 | GO:0006337 | nucleosome disassembly | 8895581 |
Hgene | ARID2 | GO:0008285 | negative regulation of cell proliferation | 26169693 |
Hgene | ARID2 | GO:0030336 | negative regulation of cell migration | 26169693 |
Tgene | TMPRSS2 | GO:0006508 | proteolysis | 21068237|24227843 |
Tgene | TMPRSS2 | GO:0046598 | positive regulation of viral entry into host cell | 21068237|24227843 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-B6-A0RH-01A | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
ChimerDB4 | BRCA | TCGA-B6-A0RH-01A | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
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Fusion Gene ORF analysis for ARID2-TMPRSS2 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000479608 | ENST00000332149 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
3UTR-intron | ENST00000479608 | ENST00000332149 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
3UTR-intron | ENST00000479608 | ENST00000398585 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
3UTR-intron | ENST00000479608 | ENST00000398585 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
3UTR-intron | ENST00000479608 | ENST00000458356 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
3UTR-intron | ENST00000479608 | ENST00000458356 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
3UTR-intron | ENST00000479608 | ENST00000497881 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
3UTR-intron | ENST00000479608 | ENST00000497881 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
5CDS-intron | ENST00000334344 | ENST00000332149 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
5CDS-intron | ENST00000334344 | ENST00000332149 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
5CDS-intron | ENST00000334344 | ENST00000398585 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
5CDS-intron | ENST00000334344 | ENST00000398585 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
5CDS-intron | ENST00000334344 | ENST00000458356 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
5CDS-intron | ENST00000334344 | ENST00000458356 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
5CDS-intron | ENST00000334344 | ENST00000497881 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
5CDS-intron | ENST00000334344 | ENST00000497881 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
5CDS-intron | ENST00000422737 | ENST00000332149 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
5CDS-intron | ENST00000422737 | ENST00000332149 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
5CDS-intron | ENST00000422737 | ENST00000398585 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
5CDS-intron | ENST00000422737 | ENST00000398585 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
5CDS-intron | ENST00000422737 | ENST00000458356 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
5CDS-intron | ENST00000422737 | ENST00000458356 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
5CDS-intron | ENST00000422737 | ENST00000497881 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
5CDS-intron | ENST00000422737 | ENST00000497881 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
5CDS-intron | ENST00000444670 | ENST00000332149 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
5CDS-intron | ENST00000444670 | ENST00000332149 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
5CDS-intron | ENST00000444670 | ENST00000398585 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
5CDS-intron | ENST00000444670 | ENST00000398585 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
5CDS-intron | ENST00000444670 | ENST00000458356 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
5CDS-intron | ENST00000444670 | ENST00000458356 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
5CDS-intron | ENST00000444670 | ENST00000497881 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
5CDS-intron | ENST00000444670 | ENST00000497881 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
intron-intron | ENST00000457135 | ENST00000332149 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
intron-intron | ENST00000457135 | ENST00000332149 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
intron-intron | ENST00000457135 | ENST00000398585 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
intron-intron | ENST00000457135 | ENST00000398585 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
intron-intron | ENST00000457135 | ENST00000458356 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
intron-intron | ENST00000457135 | ENST00000458356 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
intron-intron | ENST00000457135 | ENST00000497881 | ARID2 | chr12 | 46233279 | + | TMPRSS2 | chr21 | 42902141 | - |
intron-intron | ENST00000457135 | ENST00000497881 | ARID2 | chr12 | 46233279 | - | TMPRSS2 | chr21 | 42902145 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ARID2-TMPRSS2 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ARID2-TMPRSS2 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:46233279/:42902141) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | TMPRSS2 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity). {ECO:0000250|UniProtKB:Q9JIQ8, ECO:0000269|PubMed:15537383, ECO:0000269|PubMed:25122198, ECO:0000269|PubMed:26018085}.; FUNCTION: (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651, PubMed:32404436, PubMed:34159616, PubMed:33051876). Upon SARS-CoV-2 infection, increases syncytia formation by accelerating the fusion process (PubMed:34159616, PubMed:33051876). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. {ECO:0000269|PubMed:21068237, ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651, ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32404436, ECO:0000269|PubMed:33051876, ECO:0000269|PubMed:34159616}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ARID2-TMPRSS2 |
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Fusion Gene PPI Analysis for ARID2-TMPRSS2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ARID2-TMPRSS2 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ARID2-TMPRSS2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ARID2 | C2239176 | Liver carcinoma | 2 | CGI;CTD_human |
Hgene | ARID2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | ARID2 | C0265338 | Coffin-Siris syndrome | 1 | ORPHANET |
Hgene | ARID2 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
Tgene | C0033578 | Prostatic Neoplasms | 4 | CTD_human | |
Tgene | C0376358 | Malignant neoplasm of prostate | 4 | CTD_human |