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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ELF1-VWA8 (FusionGDB2 ID:HG1997TG23078) |
Fusion Gene Summary for ELF1-VWA8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ELF1-VWA8 | Fusion gene ID: hg1997tg23078 | Hgene | Tgene | Gene symbol | ELF1 | VWA8 | Gene ID | 1997 | 23078 |
| Gene name | E74 like ETS transcription factor 1 | von Willebrand factor A domain containing 8 | |
| Synonyms | EFTUD1|RIA1 | KIAA0564|P7BP2 | |
| Cytomap | ('ELF1','ELF1')('KIAA0564','VWA8') 13q14.11 | 13q14.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ETS-related transcription factor Elf-1E74-like factor 1 (ets domain transcription factor) | von Willebrand factor A domain-containing protein 8PEX7-binding protein 2 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P32519 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000239882, ENST00000442101, ENST00000498824, | ||
| Fusion gene scores | * DoF score | 18 X 11 X 6=1188 | 6 X 6 X 6=216 |
| # samples | 17 | 6 | |
| ** MAII score | log2(17/1188*10)=-2.80492818466306 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/216*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ELF1 [Title/Abstract] AND VWA8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ELF1(41556119)-KIAA0564(42465723), # samples:1 ELF1(41556119)-VWA8(42465723), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ELF1-VWA8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ELF1-VWA8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ELF1-VWA8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ELF1-VWA8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ELF1 | GO:0045893 | positive regulation of transcription, DNA-templated | 19674970 |
| Hgene | ELF1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 8756667|14970218|19674970 |
| Fusion gene breakpoints across ELF1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across VWA8 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BLCA | TCGA-4Z-AA80-01A | ELF1 | chr13 | 41556119 | - | KIAA0564 | chr13 | 42465723 | - |
| ChimerDB4 | BLCA | TCGA-4Z-AA80-01A | ELF1 | chr13 | 41556119 | - | VWA8 | chr13 | 42465723 | - |
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Fusion Gene ORF analysis for ELF1-VWA8 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000239882 | ENST00000478987 | ELF1 | chr13 | 41556119 | - | VWA8 | chr13 | 42465723 | - |
| 5CDS-intron | ENST00000442101 | ENST00000478987 | ELF1 | chr13 | 41556119 | - | VWA8 | chr13 | 42465723 | - |
| 5UTR-3CDS | ENST00000498824 | ENST00000281496 | ELF1 | chr13 | 41556119 | - | VWA8 | chr13 | 42465723 | - |
| 5UTR-3CDS | ENST00000498824 | ENST00000379310 | ELF1 | chr13 | 41556119 | - | VWA8 | chr13 | 42465723 | - |
| 5UTR-intron | ENST00000498824 | ENST00000478987 | ELF1 | chr13 | 41556119 | - | VWA8 | chr13 | 42465723 | - |
| In-frame | ENST00000239882 | ENST00000281496 | ELF1 | chr13 | 41556119 | - | VWA8 | chr13 | 42465723 | - |
| In-frame | ENST00000239882 | ENST00000379310 | ELF1 | chr13 | 41556119 | - | VWA8 | chr13 | 42465723 | - |
| In-frame | ENST00000442101 | ENST00000281496 | ELF1 | chr13 | 41556119 | - | VWA8 | chr13 | 42465723 | - |
| In-frame | ENST00000442101 | ENST00000379310 | ELF1 | chr13 | 41556119 | - | VWA8 | chr13 | 42465723 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000442101 | ELF1 | chr13 | 41556119 | - | ENST00000379310 | VWA8 | chr13 | 42465723 | - | 6895 | 300 | 228 | 5534 | 1768 |
| ENST00000442101 | ELF1 | chr13 | 41556119 | - | ENST00000281496 | VWA8 | chr13 | 42465723 | - | 3187 | 300 | 228 | 2936 | 902 |
| ENST00000239882 | ELF1 | chr13 | 41556119 | - | ENST00000379310 | VWA8 | chr13 | 42465723 | - | 6982 | 387 | 315 | 5621 | 1768 |
| ENST00000239882 | ELF1 | chr13 | 41556119 | - | ENST00000281496 | VWA8 | chr13 | 42465723 | - | 3274 | 387 | 315 | 3023 | 902 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000442101 | ENST00000379310 | ELF1 | chr13 | 41556119 | - | VWA8 | chr13 | 42465723 | - | 0.000270412 | 0.9997296 |
| ENST00000442101 | ENST00000281496 | ELF1 | chr13 | 41556119 | - | VWA8 | chr13 | 42465723 | - | 0.000369035 | 0.9996309 |
| ENST00000239882 | ENST00000379310 | ELF1 | chr13 | 41556119 | - | VWA8 | chr13 | 42465723 | - | 0.000293719 | 0.9997062 |
| ENST00000239882 | ENST00000281496 | ELF1 | chr13 | 41556119 | - | VWA8 | chr13 | 42465723 | - | 0.000344182 | 0.99965584 |
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Fusion Genomic Features for ELF1-VWA8 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for ELF1-VWA8 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:41556119/chr13:42465723) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ELF1 | . |
| FUNCTION: Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. {ECO:0000269|PubMed:8756667}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | VWA8 | chr13:41556119 | chr13:42465723 | ENST00000281496 | 3 | 26 | 1714_1896 | 161 | 1040.0 | Domain | VWFA | |
| Tgene | VWA8 | chr13:41556119 | chr13:42465723 | ENST00000379310 | 3 | 45 | 1714_1896 | 161 | 1906.0 | Domain | VWFA | |
| Tgene | VWA8 | chr13:41556119 | chr13:42465723 | ENST00000281496 | 3 | 26 | 447_454 | 161 | 1040.0 | Nucleotide binding | ATP | |
| Tgene | VWA8 | chr13:41556119 | chr13:42465723 | ENST00000379310 | 3 | 45 | 447_454 | 161 | 1906.0 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ELF1 | chr13:41556119 | chr13:42465723 | ENST00000239882 | - | 2 | 9 | 75_80 | 24 | 620.0 | Compositional bias | Note=Poly-Asp |
| Hgene | ELF1 | chr13:41556119 | chr13:42465723 | ENST00000442101 | - | 1 | 8 | 75_80 | 24 | 596.0 | Compositional bias | Note=Poly-Asp |
| Hgene | ELF1 | chr13:41556119 | chr13:42465723 | ENST00000239882 | - | 2 | 9 | 208_290 | 24 | 620.0 | DNA binding | ETS |
| Hgene | ELF1 | chr13:41556119 | chr13:42465723 | ENST00000442101 | - | 1 | 8 | 208_290 | 24 | 596.0 | DNA binding | ETS |
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Fusion Gene Sequence for ELF1-VWA8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >26163_26163_1_ELF1-VWA8_ELF1_chr13_41556119_ENST00000239882_VWA8_chr13_42465723_ENST00000281496_length(transcript)=3274nt_BP=387nt TCTACAGGAGCCATTTTAACAGCTAAAACTTGTCGGATTGCTTTTTATTTTCAAGCTCAAAAGACGATAGAGAAAGAATACTTGAAGGCC AAGAAGCTTGAGAGAAGAAAAATTTCAGAAAAATTGTCTCAATTTGACTAGAATATCAATGAACCAGGAAAACTGAAGCACCTTCCCTAA AGAAAACTTGGGTATACAATTACTCCACAGACAGAGCTGAGGGTTTTTTACCCAAATCAGTCACTGGATTTTGCTGCCTGATACGTGAAT CTTCTTGGAATTTTTCTCATGTGGATCTAAGGGGAATGCTTTATTATGGCTGCTGTTGTCCAACAGAACGACCTAGTATTTGAATTTGCT AGTAACGTCATGGAGGATGAACGACAGTGTGCAGTTCGTGCAGCCACAGAAGGCAGAACTCTCATTTTGGAAGGTTTGGAAAAGGCAGAG AGGAATGTTTTGCCTGTTTTGAACAACTTGCTGGAAAACAGAGAGATGCAGCTTGAAGATGGACGCTTCCTGATGTCTGCTGAGCGTTAC GACAAACTTCTCCGAGATCATACCAAAAAAGAGTTGGATTCTTGGAAAATTGTCCGAGTTAGTGAAAATTTCCGAGTGATTGCCTTGGGC TTGCCAGTGCCAAGGTATTCTGGGAATCCATTAGACCCCCCTCTTCGTTCTCGATTTCAAGCCAGGGATATTTATTATTTACCCTTCAAG GACCAACTTAAGTTGTTATATTCAATTGGAGCCAATGTTTCTGCTGAGAAAGTTTCTCAGCTCTTGTCCTTTGCCACAACTCTGTGTTCC CAAGAATCTTCTACTCTTGGACTTCCAGACTTTCCTTTAGATAGTTTAGCAGCTGCGGTTCAAATCTTGGATTCCTTTCCTATGATGCCA ATCAAACATGCAATCCAGTGGCTTTATCCATATAGTATTTTACTAGGTCATGAAGGGAAGATGGCTGTGGAAGGTGTTTTAAAGCGCTTT GAACTTCAAGATTCAGGAAGCTCTCTACTTCCTAAAGAGATTGTAAAAGTAGAGAAGATGATGGAAAACCATGTGTCCCAAGCTTCTGTG ACCATCCGGATTGCAGATAAAGAGGTGACCATTAAGGTGCCAGCCGGGACCAGGCTATTAAGTCAACCTTGTGCGTCAGACCGTTTCATA CAGACTTTGAGCCATAAGCAGCTACAGGCTGAAATGATGCAGTCTCACATGGTTAAAGATATATGTTTAATTGGAGGAAAGGGTTGTGGA AAAACAGTGATCGCTAAGAACTTTGCCGATACCTTAGGATACAACATAGAACCTATTATGCTCTATCAGGATATGACAGCGCGTGATCTG CTACAGCAGAGATACACCCTTCCAAATGGAGACACTGCCTGGCGGTCCTCACCCCTTGTGAATGCTGCTCTGGAAGGCAAGCTGGTCCTG CTGGATGGCATTCACCGGGTGAATGCGGGCACGCTTGCTGTATTGCAAAGGTTAATCCATGATCGAGAGCTAAGCCTCTATGATGGTTCT AGGCTGCTGAGAGAAGACAGGTATATGCGTTTAAAGGAGGAGCTGCAACTGTCTGATGAACAGCTACAGAAGAGATCCATTTTTCCTATC CATCCCTCCTTCAGAATCATTGCCTTGGCAGAACCCCCTGTTATTGGAAGCACAGCACACCAGTGGCTGGGACCAGAATTCTTAACCATG TTCTTTTTCCATTACATGAAACCACTTGTGAAAAGTGAAGAAATCCAAGTGATTAAGGAAAAGGTCCCAAATGTACCTCAGGAAGCTCTG GATAAGTTATTATCATTTACACACAAACTCAGAGAAACACAGGATCCAACGGCACAATCATTAGCGGCATCACTTTCTACCAGACAACTG TTGCGAATTTCTCGTCGGCTGTCACAGTATCCTAATGAAAATCTTCACAGTGCTGTTACTAAAGCCTGCCTTTCCAGGTTTTTACCCAGT CTTGCTAGGTCAGCATTAGAAAAAAATCTGGCAGATGCTACAATAGAAATAAATACTGATGACAATTTGGAGCCAGAACTGAAGGATTAC AAATGTGAAGTAACATCTGGAACTCTGAGGATTGGTGCTGTTAGTGCACCGATCTATAATGCACATGAGAAAATGAAAGTGCCTGATGTT CTTTTCTATGACAACATTCAGCATGTGATAGTGATGGAAGATATGCTGAAAGACTTTCTCCTTGGAGAACACTTATTATTGGTTGGCAAC CAGGGTGTAGGAAAAAACAAGATTGTTGACAGATTCCTTCACCTGCTCAACAGACCCCGAGAATATATTCAGCTACACAGGGATACCACA GTACAAACTCTTACGCTTCAGCCTTCGGTTAAAGACGGACTTATTGTATATGAAGACTCACCTTTGGTTAAAGCAGTAAAGTTGGGTCAT ATTCTGGTAGTAGATGAGGCTGACAAAGCTCCAACAAATGTCACGTGTATTTTAAAAACTCTAGTAGAAAATGGAGAAATGATTCTAGCA GATGGAAGACGCATTGTTGCAAATTCTGCTAATGTGAATGGAAGAGAAAATGTTGTAGTGATTCATCCTGATTTTAGGATGATTGTTCTG GCAAATAGACCTGGATTTCCTTTCCTAGGCAATGATTTCTTCGGTACCTTAGGTGATATTTTTAGCTGCCATGCAGTTGATAACCCCAAA CCCCACTCGGAGCTCGAGATGCTCAGACAGTATGGACCAAATGTGCCTGAGCCCATCCTTCAGAAGCTTGTGGCTGCCTTTGGAGAGCTG AGGAGTTTGGCTGACCAAGGGATTATTAACTATCCTTATTCTACCAGAGAAGTTGTCAACATAGTCAAACATTTACAGAAATTTCCGACT GAAGGTCTCTCCAGTGTAGTTCGAAATGTGTTTGACTTTGATTCCTACAACAATGACATGAGGGAGATATTGATTAACACTTTACACAAA TACGGGATACCTATCGGAGCAAAGCCTACCAGTGTGCAGCTGGCAAAGGAGTAAGGCAAATTCAGTACTCTTCTGATTCTTAAATGCTGA TAGTTCTTGATTTATCATTCCATTCTACAAAACTGAGTTGCTATGGAAATTACTTTCCATGAGTAAGCTTTTCAAATACATGTATATGTT GCTGTTTGCTGGCTGCTTTTCAGTTAAATAGCATTATTTATAGGCCTGTAAATTGAAAATTTTGATTATTATGTATGTCCCATGAGTAGA >26163_26163_1_ELF1-VWA8_ELF1_chr13_41556119_ENST00000239882_VWA8_chr13_42465723_ENST00000281496_length(amino acids)=902AA_BP=24 MAAVVQQNDLVFEFASNVMEDERQCAVRAATEGRTLILEGLEKAERNVLPVLNNLLENREMQLEDGRFLMSAERYDKLLRDHTKKELDSW KIVRVSENFRVIALGLPVPRYSGNPLDPPLRSRFQARDIYYLPFKDQLKLLYSIGANVSAEKVSQLLSFATTLCSQESSTLGLPDFPLDS LAAAVQILDSFPMMPIKHAIQWLYPYSILLGHEGKMAVEGVLKRFELQDSGSSLLPKEIVKVEKMMENHVSQASVTIRIADKEVTIKVPA GTRLLSQPCASDRFIQTLSHKQLQAEMMQSHMVKDICLIGGKGCGKTVIAKNFADTLGYNIEPIMLYQDMTARDLLQQRYTLPNGDTAWR SSPLVNAALEGKLVLLDGIHRVNAGTLAVLQRLIHDRELSLYDGSRLLREDRYMRLKEELQLSDEQLQKRSIFPIHPSFRIIALAEPPVI GSTAHQWLGPEFLTMFFFHYMKPLVKSEEIQVIKEKVPNVPQEALDKLLSFTHKLRETQDPTAQSLAASLSTRQLLRISRRLSQYPNENL HSAVTKACLSRFLPSLARSALEKNLADATIEINTDDNLEPELKDYKCEVTSGTLRIGAVSAPIYNAHEKMKVPDVLFYDNIQHVIVMEDM LKDFLLGEHLLLVGNQGVGKNKIVDRFLHLLNRPREYIQLHRDTTVQTLTLQPSVKDGLIVYEDSPLVKAVKLGHILVVDEADKAPTNVT CILKTLVENGEMILADGRRIVANSANVNGRENVVVIHPDFRMIVLANRPGFPFLGNDFFGTLGDIFSCHAVDNPKPHSELEMLRQYGPNV PEPILQKLVAAFGELRSLADQGIINYPYSTREVVNIVKHLQKFPTEGLSSVVRNVFDFDSYNNDMREILINTLHKYGIPIGAKPTSVQLA -------------------------------------------------------------- >26163_26163_2_ELF1-VWA8_ELF1_chr13_41556119_ENST00000239882_VWA8_chr13_42465723_ENST00000379310_length(transcript)=6982nt_BP=387nt TCTACAGGAGCCATTTTAACAGCTAAAACTTGTCGGATTGCTTTTTATTTTCAAGCTCAAAAGACGATAGAGAAAGAATACTTGAAGGCC AAGAAGCTTGAGAGAAGAAAAATTTCAGAAAAATTGTCTCAATTTGACTAGAATATCAATGAACCAGGAAAACTGAAGCACCTTCCCTAA AGAAAACTTGGGTATACAATTACTCCACAGACAGAGCTGAGGGTTTTTTACCCAAATCAGTCACTGGATTTTGCTGCCTGATACGTGAAT CTTCTTGGAATTTTTCTCATGTGGATCTAAGGGGAATGCTTTATTATGGCTGCTGTTGTCCAACAGAACGACCTAGTATTTGAATTTGCT AGTAACGTCATGGAGGATGAACGACAGTGTGCAGTTCGTGCAGCCACAGAAGGCAGAACTCTCATTTTGGAAGGTTTGGAAAAGGCAGAG AGGAATGTTTTGCCTGTTTTGAACAACTTGCTGGAAAACAGAGAGATGCAGCTTGAAGATGGACGCTTCCTGATGTCTGCTGAGCGTTAC GACAAACTTCTCCGAGATCATACCAAAAAAGAGTTGGATTCTTGGAAAATTGTCCGAGTTAGTGAAAATTTCCGAGTGATTGCCTTGGGC TTGCCAGTGCCAAGGTATTCTGGGAATCCATTAGACCCCCCTCTTCGTTCTCGATTTCAAGCCAGGGATATTTATTATTTACCCTTCAAG GACCAACTTAAGTTGTTATATTCAATTGGAGCCAATGTTTCTGCTGAGAAAGTTTCTCAGCTCTTGTCCTTTGCCACAACTCTGTGTTCC CAAGAATCTTCTACTCTTGGACTTCCAGACTTTCCTTTAGATAGTTTAGCAGCTGCGGTTCAAATCTTGGATTCCTTTCCTATGATGCCA ATCAAACATGCAATCCAGTGGCTTTATCCATATAGTATTTTACTAGGTCATGAAGGGAAGATGGCTGTGGAAGGTGTTTTAAAGCGCTTT GAACTTCAAGATTCAGGAAGCTCTCTACTTCCTAAAGAGATTGTAAAAGTAGAGAAGATGATGGAAAACCATGTGTCCCAAGCTTCTGTG ACCATCCGGATTGCAGATAAAGAGGTGACCATTAAGGTGCCAGCCGGGACCAGGCTATTAAGTCAACCTTGTGCGTCAGACCGTTTCATA CAGACTTTGAGCCATAAGCAGCTACAGGCTGAAATGATGCAGTCTCACATGGTTAAAGATATATGTTTAATTGGAGGAAAGGGTTGTGGA AAAACAGTGATCGCTAAGAACTTTGCCGATACCTTAGGATACAACATAGAACCTATTATGCTCTATCAGGATATGACAGCGCGTGATCTG CTACAGCAGAGATACACCCTTCCAAATGGAGACACTGCCTGGCGGTCCTCACCCCTTGTGAATGCTGCTCTGGAAGGCAAGCTGGTCCTG CTGGATGGCATTCACCGGGTGAATGCGGGCACGCTTGCTGTATTGCAAAGGTTAATCCATGATCGAGAGCTAAGCCTCTATGATGGTTCT AGGCTGCTGAGAGAAGACAGGTATATGCGTTTAAAGGAGGAGCTGCAACTGTCTGATGAACAGCTACAGAAGAGATCCATTTTTCCTATC CATCCCTCCTTCAGAATCATTGCCTTGGCAGAACCCCCTGTTATTGGAAGCACAGCACACCAGTGGCTGGGACCAGAATTCTTAACCATG TTCTTTTTCCATTACATGAAACCACTTGTGAAAAGTGAAGAAATCCAAGTGATTAAGGAAAAGGTCCCAAATGTACCTCAGGAAGCTCTG GATAAGTTATTATCATTTACACACAAACTCAGAGAAACACAGGATCCAACGGCACAATCATTAGCGGCATCACTTTCTACCAGACAACTG TTGCGAATTTCTCGTCGGCTGTCACAGTATCCTAATGAAAATCTTCACAGTGCTGTTACTAAAGCCTGCCTTTCCAGGTTTTTACCCAGT CTTGCTAGGTCAGCATTAGAAAAAAATCTGGCAGATGCTACAATAGAAATAAATACTGATGACAATTTGGAGCCAGAACTGAAGGATTAC AAATGTGAAGTAACATCTGGAACTCTGAGGATTGGTGCTGTTAGTGCACCGATCTATAATGCACATGAGAAAATGAAAGTGCCTGATGTT CTTTTCTATGACAACATTCAGCATGTGATAGTGATGGAAGATATGCTGAAAGACTTTCTCCTTGGAGAACACTTATTATTGGTTGGCAAC CAGGGTGTAGGAAAAAACAAGATTGTTGACAGATTCCTTCACCTGCTCAACAGACCCCGAGAATATATTCAGCTACACAGGGATACCACA GTACAAACTCTTACGCTTCAGCCTTCGGTTAAAGACGGACTTATTGTATATGAAGACTCACCTTTGGTTAAAGCAGTAAAGTTGGGTCAT ATTCTGGTAGTAGATGAGGCTGACAAAGCTCCAACAAATGTCACGTGTATTTTAAAAACTCTAGTAGAAAATGGAGAAATGATTCTAGCA GATGGAAGACGCATTGTTGCAAATTCTGCTAATGTGAATGGAAGAGAAAATGTTGTAGTGATTCATCCTGATTTTAGGATGATTGTTCTG GCAAATAGACCTGGATTTCCTTTCCTAGGCAATGATTTCTTCGGTACCTTAGGTGATATTTTTAGCTGCCATGCAGTTGATAACCCCAAA CCCCACTCGGAGCTCGAGATGCTCAGACAGTATGGACCAAATGTGCCTGAGCCCATCCTTCAGAAGCTTGTGGCTGCCTTTGGAGAGCTG AGGAGTTTGGCTGACCAAGGGATTATTAACTATCCTTATTCTACCAGAGAAGTTGTCAACATAGTCAAACATTTACAGAAATTTCCGACT GAAGGTCTCTCCAGTGTAGTTCGAAATGTGTTTGACTTTGATTCCTACAACAATGACATGAGGGAGATATTGATTAACACTTTACACAAA TACGGGATACCTATCGGAGCAAAGCCTACCAGTGTGCAGCTGGCAAAGGAGTTGACTCTGCCAGAACAAACGTTCATGGGCTACTGGACA ATTGGTCAGGCAAGAAGTGGGATGCAAAAACTCTTGTGTCCAGTGGAAACTCATCATATAGACATAAAGGGTCCAGCACTTATAAATATA CAGGAGTATCCAATAGAAAGACATGAAGAAAGATCCCTAAACTTTACTGAAGAATGTGCCTCATGGAGAATACCATTGGATGAAATTAAT ATAATCTGTGACATTGCTACATCACATGAAAATGAGCAAAATACTCTCTATGTAGTTACATGCAATCCCGCTTCCCTGTACTTTATGAAT ATGACTGGGAAAAGTGGCTTCTTTGTGGACTTTTTTGATATCTTCCCAAGAACAGCCAATGGCGTTTGGCACCCTTTTGTGACAGTGGCA CCGCTGGGAAGTCCTCTCAAAGGTCAAGTGGTTCTCCATGAGCAGCAGAGTAATGTTATCCTGTTGTTAGATACTACTGGCCGGGCCCTT CATCGTCTCATCCTCCCTTCCGAGAAGTTTACATCTAAGAAACCTTTCTGGTGGAACAAAGAAGAAGCTGAAACTTATAAAATGTGTAAA GAATTTTCACACAAAAACTGGCTGGTGTTCTACAAAGAAAAAGGGAACAGCCTGACTGTGCTGGATGTTCTAGAAGGGCGAACTCACACC ATCTCACTTCCCATCAACCTCAAGACAGTTTTCCTTGTAGCAGAGGACAAATGGCTTCTGGTGGAGAGCAAAACAAATCAGAAATATCTT TTAACTAAGCCTGCACACATCGAATCTGAGGGTAGTGGGGTTTGCCAGTTGTATGTGCTGAAAGAGGAGCCGCCCAGCACAGGGTTTGGA GTTACACAAGAAACAGAGTTCAGCATACCTCATAAAATTTCCAGTGATCAACTATCATCTGAACATCTAAGTTCAGCTGTGGAACAAAAG ATTGCCTCTCCCAACAGAATTCTCTCAGATGAGAAAAATTATGCTACAATAGTTGTTGGTTTTCCAGATCTCATGTCACCCAGTGAAGTT TATTCTTGGAAGAGACCATCATCTTTGCATAAACGAAGTGGCACTGATACATCATTCTATAGAGGAAAGAAGAAAAGGGGGACTCCAAAA CAAAGCAATTGTGTGACTCTTTTAGATACGAATCAGGTAGTGAGGATTTTACCCCCAGGAGAAGTCCCTCTAAAAGATATCTACCCAAAA GATGTTACTCCTCCACAAACATCTGGTTATATAGAAGTCACTGATCTTCAATCAAAGAAACTCCGATATATCCCTATTCCCAGATCAGAA TCTCTCTCGCCGTATACCACATGGCTGTCGACCATTTCAGACACAGATGCACTGCTGGCTGAGTGGGACAAAAGCGGTGTTGTTACTGTT GATATGGGAGGTCACATCAGGCTTTGGGAAACTGGACTTGAACGTCTGCAGCGATCACTCATGGAATGGAGAAACATGATTGGACAAGAT GACAGAAATATGCAGATAACAATCAACAGAGACAGTGGTGAAGATGTAAGCTCCCCCAAACACGGGAAGGAGGACCCAGACAACATGCCT CACGTGGGCGGCAACACTTGGGCTGGCGGAACAGGGGGAAGAGACACGGCAGGCCTGGGTGGCAAAGGAGGCCCTTACCGGCTGGATGCA GGCCATACGGTGTACCAGGTCTCTCAGGCTGAGAAAGATGCAGTTCCCGAAGAGGTCAAGAGAGCTGCTAGAGAGATGGGCCAGAGAGCA TTCCAGCAGAGGCTAAAGGAGATCCAAATGAGTGAATACGATGCTGCAACCTATGAAAGGTTTTCAGGTGCTGTTCGGCGACAGGTGCAC TCCCTCCGAATCATCCTGGATAATTTACAGGCTAAAGGTAAAGAAAGACAATGGCTAAGACATCAAGCTACTGGAGAATTAGATGATGCC AAGATCATTGATGGGCTGACTGGAGAAAAAGCCATCTACAAACGTCGGGGTGAGCTGGAGCCACAACTTGGCAGCCCACAACAGAAACCC AAGCGTCTGCGCCTGGTGGTAGATGTGTCTGGTAGCATGTACCGTTTCAACAGGATGGATGGCCGGCTTGAGCGCACAATGGAGGCTGTG TGTATGGTCATGGAAGCCTTCGAGAACTATGAGGAGAAGTTCCAGTATGACATCGTTGGACACTCTGGAGATGGCTACAACATTGGTCTG GTTCCAATGAACAAAATCCCCAAGGACAATAAGCAAAGACTAGAAATTCTGAAGACAATGCATGCCCACTCTCAGTTCTGCATGAGTGGG GACCACACGTTAGAAGGGACAGAACATGCCATCAAGGAAATTGTCAAAGAAGAAGCTGATGAGTACTTTGTCATAGTCTTGAGTGATGCA AATCTGTCACGATATGGAATACATCCTGCTAAGTTTGCTCAAATCCTCACAAGAGACCCTCAAGTAAATGCTTTTGCCATTTTTATTGGC TCTTTAGGTGATCAAGCAACCAGGCTTCAGAGAACTTTACCAGCTGGTCGGTCTTTCGTTGCCATGGATACCAAGGATATCCCTCAGATT TTACAACAGATCTTCACCTCCACCATGTTGTCGAGTGTCTAAGAAGTGCCCTTCATCACCCTGATGACACCAGGATTTGAAATAAGACAG GAATAAAGAGTATTCTGAAAAAAAGAAGATATGGATGAAGTGAACCCATGCAGTGACTGGATGATTCCGGCATTCCTGGGTCTTCCTACA CTTGCTCCGTAATGAGAATTCAGAGAAGCAGCCAGAAGGAGACTTAAACATGGAAAGATACTCCACTGATGAGTTTAGAAGTGATTAGGG CAAGCTAGTTGACCTGCACTTTATCAAAGGTTGGGGTTAAAGGAAGGTGGTTTTGAGAACTATGTGTTTGGTCTATTTCCAAAAACCTGA GGGGGAGAAAATACTTTGCTTTTGCCTTAACACATCATCTGGTCACGTTAGAAAAGTGACCCCATCAAACTGAGCCTTTGATGTCACATT CTGACACAAGATGCAAGTCTGTGCAAAACCCACCAAAATGCTCCTATCCAACAATTATTTTTATTTTCTCCCTGCTCTGTATTGACCAGA AAACAATGATTTTATAATATTTAACCCACCAAAAAGTCCCTCCAACAGCAATATCTTATGAAAGTCTGGCTGTTCTCAATAATTTCATTT TCTTGGCCAAAGCCAAAAGGAATCAAAAAATCCTTGGAGTGCTTGCCTTTCCACGTGACTTTTAAAAGGCTCTTAAAGAGCAAATGTCCT CTTCTCCTTGCTGCTAGAGTGGGAGGAGAAAGATGTCTTGCCTTAAAAGTTTACTGTTTCTTCTGTTCTTCTAGCATCTCTCAAAAAATT CACAGTACTCCATTTTGGGGTCCAAACTGTAATGCTCAAAATAATAAATGCTTACACGAAAATTATTTATTGAGAATATTCATATAAAAA TTACCTAAAGCAAAGTAAAAAAAGTAAAATCAAGGTGGTATATTTGAAGTGAATGGTGATTGGAAATTTTTAGCTGTAACAAAAAGAAAG AAAACAACTTTTTTTAAAGCCTCATTCTCTTTTCTTTCAAAATGTACCTTATTCCCACACACTCTTGGGCTGACCTTTATTTTATCAATA AGCTCAATATTACTTTGTTTAAAATAAGATGCTTCAGCAAAAGTCATTCTCTCTTTAACCATATAATTTAAAAACTCCTCTTCACGATTG ATAGCAAAATCAGAAACGTTAGGGCACCAGTGAGTTGAAAAAACTGGTCTTAAGTTGGAAAAACTATTATTAATAATATTATCCTATCCA TCCATATCTATTGAAATTGTACAGGTCCATAATTTCATTTTAATTAATTATAGGAAAGAAGAAAAGATAATACCCATTTGTTCTATCACC >26163_26163_2_ELF1-VWA8_ELF1_chr13_41556119_ENST00000239882_VWA8_chr13_42465723_ENST00000379310_length(amino acids)=1768AA_BP=24 MAAVVQQNDLVFEFASNVMEDERQCAVRAATEGRTLILEGLEKAERNVLPVLNNLLENREMQLEDGRFLMSAERYDKLLRDHTKKELDSW KIVRVSENFRVIALGLPVPRYSGNPLDPPLRSRFQARDIYYLPFKDQLKLLYSIGANVSAEKVSQLLSFATTLCSQESSTLGLPDFPLDS LAAAVQILDSFPMMPIKHAIQWLYPYSILLGHEGKMAVEGVLKRFELQDSGSSLLPKEIVKVEKMMENHVSQASVTIRIADKEVTIKVPA GTRLLSQPCASDRFIQTLSHKQLQAEMMQSHMVKDICLIGGKGCGKTVIAKNFADTLGYNIEPIMLYQDMTARDLLQQRYTLPNGDTAWR SSPLVNAALEGKLVLLDGIHRVNAGTLAVLQRLIHDRELSLYDGSRLLREDRYMRLKEELQLSDEQLQKRSIFPIHPSFRIIALAEPPVI GSTAHQWLGPEFLTMFFFHYMKPLVKSEEIQVIKEKVPNVPQEALDKLLSFTHKLRETQDPTAQSLAASLSTRQLLRISRRLSQYPNENL HSAVTKACLSRFLPSLARSALEKNLADATIEINTDDNLEPELKDYKCEVTSGTLRIGAVSAPIYNAHEKMKVPDVLFYDNIQHVIVMEDM LKDFLLGEHLLLVGNQGVGKNKIVDRFLHLLNRPREYIQLHRDTTVQTLTLQPSVKDGLIVYEDSPLVKAVKLGHILVVDEADKAPTNVT CILKTLVENGEMILADGRRIVANSANVNGRENVVVIHPDFRMIVLANRPGFPFLGNDFFGTLGDIFSCHAVDNPKPHSELEMLRQYGPNV PEPILQKLVAAFGELRSLADQGIINYPYSTREVVNIVKHLQKFPTEGLSSVVRNVFDFDSYNNDMREILINTLHKYGIPIGAKPTSVQLA KELTLPEQTFMGYWTIGQARSGMQKLLCPVETHHIDIKGPALINIQEYPIERHEERSLNFTEECASWRIPLDEINIICDIATSHENEQNT LYVVTCNPASLYFMNMTGKSGFFVDFFDIFPRTANGVWHPFVTVAPLGSPLKGQVVLHEQQSNVILLLDTTGRALHRLILPSEKFTSKKP FWWNKEEAETYKMCKEFSHKNWLVFYKEKGNSLTVLDVLEGRTHTISLPINLKTVFLVAEDKWLLVESKTNQKYLLTKPAHIESEGSGVC QLYVLKEEPPSTGFGVTQETEFSIPHKISSDQLSSEHLSSAVEQKIASPNRILSDEKNYATIVVGFPDLMSPSEVYSWKRPSSLHKRSGT DTSFYRGKKKRGTPKQSNCVTLLDTNQVVRILPPGEVPLKDIYPKDVTPPQTSGYIEVTDLQSKKLRYIPIPRSESLSPYTTWLSTISDT DALLAEWDKSGVVTVDMGGHIRLWETGLERLQRSLMEWRNMIGQDDRNMQITINRDSGEDVSSPKHGKEDPDNMPHVGGNTWAGGTGGRD TAGLGGKGGPYRLDAGHTVYQVSQAEKDAVPEEVKRAAREMGQRAFQQRLKEIQMSEYDAATYERFSGAVRRQVHSLRIILDNLQAKGKE RQWLRHQATGELDDAKIIDGLTGEKAIYKRRGELEPQLGSPQQKPKRLRLVVDVSGSMYRFNRMDGRLERTMEAVCMVMEAFENYEEKFQ YDIVGHSGDGYNIGLVPMNKIPKDNKQRLEILKTMHAHSQFCMSGDHTLEGTEHAIKEIVKEEADEYFVIVLSDANLSRYGIHPAKFAQI -------------------------------------------------------------- >26163_26163_3_ELF1-VWA8_ELF1_chr13_41556119_ENST00000442101_VWA8_chr13_42465723_ENST00000281496_length(transcript)=3187nt_BP=300nt GCCAAGAAGCTTGAGAGAAGAAAAATTTCAGAAAAATTGTCTCAATTTGACTAGAATATCAATGAACCAGGAAAACTGAAGCACCTTCCC TAAAGAAAACTTGGGTATACAATTACTCCACAGACAGAGCTGAGGGTTTTTTACCCAAATCAGTCACTGGATTTTGCTGCCTGATACGTG AATCTTCTTGGAATTTTTCTCATGTGGATCTAAGGGGAATGCTTTATTATGGCTGCTGTTGTCCAACAGAACGACCTAGTATTTGAATTT GCTAGTAACGTCATGGAGGATGAACGACAGTGTGCAGTTCGTGCAGCCACAGAAGGCAGAACTCTCATTTTGGAAGGTTTGGAAAAGGCA GAGAGGAATGTTTTGCCTGTTTTGAACAACTTGCTGGAAAACAGAGAGATGCAGCTTGAAGATGGACGCTTCCTGATGTCTGCTGAGCGT TACGACAAACTTCTCCGAGATCATACCAAAAAAGAGTTGGATTCTTGGAAAATTGTCCGAGTTAGTGAAAATTTCCGAGTGATTGCCTTG GGCTTGCCAGTGCCAAGGTATTCTGGGAATCCATTAGACCCCCCTCTTCGTTCTCGATTTCAAGCCAGGGATATTTATTATTTACCCTTC AAGGACCAACTTAAGTTGTTATATTCAATTGGAGCCAATGTTTCTGCTGAGAAAGTTTCTCAGCTCTTGTCCTTTGCCACAACTCTGTGT TCCCAAGAATCTTCTACTCTTGGACTTCCAGACTTTCCTTTAGATAGTTTAGCAGCTGCGGTTCAAATCTTGGATTCCTTTCCTATGATG CCAATCAAACATGCAATCCAGTGGCTTTATCCATATAGTATTTTACTAGGTCATGAAGGGAAGATGGCTGTGGAAGGTGTTTTAAAGCGC TTTGAACTTCAAGATTCAGGAAGCTCTCTACTTCCTAAAGAGATTGTAAAAGTAGAGAAGATGATGGAAAACCATGTGTCCCAAGCTTCT GTGACCATCCGGATTGCAGATAAAGAGGTGACCATTAAGGTGCCAGCCGGGACCAGGCTATTAAGTCAACCTTGTGCGTCAGACCGTTTC ATACAGACTTTGAGCCATAAGCAGCTACAGGCTGAAATGATGCAGTCTCACATGGTTAAAGATATATGTTTAATTGGAGGAAAGGGTTGT GGAAAAACAGTGATCGCTAAGAACTTTGCCGATACCTTAGGATACAACATAGAACCTATTATGCTCTATCAGGATATGACAGCGCGTGAT CTGCTACAGCAGAGATACACCCTTCCAAATGGAGACACTGCCTGGCGGTCCTCACCCCTTGTGAATGCTGCTCTGGAAGGCAAGCTGGTC CTGCTGGATGGCATTCACCGGGTGAATGCGGGCACGCTTGCTGTATTGCAAAGGTTAATCCATGATCGAGAGCTAAGCCTCTATGATGGT TCTAGGCTGCTGAGAGAAGACAGGTATATGCGTTTAAAGGAGGAGCTGCAACTGTCTGATGAACAGCTACAGAAGAGATCCATTTTTCCT ATCCATCCCTCCTTCAGAATCATTGCCTTGGCAGAACCCCCTGTTATTGGAAGCACAGCACACCAGTGGCTGGGACCAGAATTCTTAACC ATGTTCTTTTTCCATTACATGAAACCACTTGTGAAAAGTGAAGAAATCCAAGTGATTAAGGAAAAGGTCCCAAATGTACCTCAGGAAGCT CTGGATAAGTTATTATCATTTACACACAAACTCAGAGAAACACAGGATCCAACGGCACAATCATTAGCGGCATCACTTTCTACCAGACAA CTGTTGCGAATTTCTCGTCGGCTGTCACAGTATCCTAATGAAAATCTTCACAGTGCTGTTACTAAAGCCTGCCTTTCCAGGTTTTTACCC AGTCTTGCTAGGTCAGCATTAGAAAAAAATCTGGCAGATGCTACAATAGAAATAAATACTGATGACAATTTGGAGCCAGAACTGAAGGAT TACAAATGTGAAGTAACATCTGGAACTCTGAGGATTGGTGCTGTTAGTGCACCGATCTATAATGCACATGAGAAAATGAAAGTGCCTGAT GTTCTTTTCTATGACAACATTCAGCATGTGATAGTGATGGAAGATATGCTGAAAGACTTTCTCCTTGGAGAACACTTATTATTGGTTGGC AACCAGGGTGTAGGAAAAAACAAGATTGTTGACAGATTCCTTCACCTGCTCAACAGACCCCGAGAATATATTCAGCTACACAGGGATACC ACAGTACAAACTCTTACGCTTCAGCCTTCGGTTAAAGACGGACTTATTGTATATGAAGACTCACCTTTGGTTAAAGCAGTAAAGTTGGGT CATATTCTGGTAGTAGATGAGGCTGACAAAGCTCCAACAAATGTCACGTGTATTTTAAAAACTCTAGTAGAAAATGGAGAAATGATTCTA GCAGATGGAAGACGCATTGTTGCAAATTCTGCTAATGTGAATGGAAGAGAAAATGTTGTAGTGATTCATCCTGATTTTAGGATGATTGTT CTGGCAAATAGACCTGGATTTCCTTTCCTAGGCAATGATTTCTTCGGTACCTTAGGTGATATTTTTAGCTGCCATGCAGTTGATAACCCC AAACCCCACTCGGAGCTCGAGATGCTCAGACAGTATGGACCAAATGTGCCTGAGCCCATCCTTCAGAAGCTTGTGGCTGCCTTTGGAGAG CTGAGGAGTTTGGCTGACCAAGGGATTATTAACTATCCTTATTCTACCAGAGAAGTTGTCAACATAGTCAAACATTTACAGAAATTTCCG ACTGAAGGTCTCTCCAGTGTAGTTCGAAATGTGTTTGACTTTGATTCCTACAACAATGACATGAGGGAGATATTGATTAACACTTTACAC AAATACGGGATACCTATCGGAGCAAAGCCTACCAGTGTGCAGCTGGCAAAGGAGTAAGGCAAATTCAGTACTCTTCTGATTCTTAAATGC TGATAGTTCTTGATTTATCATTCCATTCTACAAAACTGAGTTGCTATGGAAATTACTTTCCATGAGTAAGCTTTTCAAATACATGTATAT GTTGCTGTTTGCTGGCTGCTTTTCAGTTAAATAGCATTATTTATAGGCCTGTAAATTGAAAATTTTGATTATTATGTATGTCCCATGAGT >26163_26163_3_ELF1-VWA8_ELF1_chr13_41556119_ENST00000442101_VWA8_chr13_42465723_ENST00000281496_length(amino acids)=902AA_BP=24 MAAVVQQNDLVFEFASNVMEDERQCAVRAATEGRTLILEGLEKAERNVLPVLNNLLENREMQLEDGRFLMSAERYDKLLRDHTKKELDSW KIVRVSENFRVIALGLPVPRYSGNPLDPPLRSRFQARDIYYLPFKDQLKLLYSIGANVSAEKVSQLLSFATTLCSQESSTLGLPDFPLDS LAAAVQILDSFPMMPIKHAIQWLYPYSILLGHEGKMAVEGVLKRFELQDSGSSLLPKEIVKVEKMMENHVSQASVTIRIADKEVTIKVPA GTRLLSQPCASDRFIQTLSHKQLQAEMMQSHMVKDICLIGGKGCGKTVIAKNFADTLGYNIEPIMLYQDMTARDLLQQRYTLPNGDTAWR SSPLVNAALEGKLVLLDGIHRVNAGTLAVLQRLIHDRELSLYDGSRLLREDRYMRLKEELQLSDEQLQKRSIFPIHPSFRIIALAEPPVI GSTAHQWLGPEFLTMFFFHYMKPLVKSEEIQVIKEKVPNVPQEALDKLLSFTHKLRETQDPTAQSLAASLSTRQLLRISRRLSQYPNENL HSAVTKACLSRFLPSLARSALEKNLADATIEINTDDNLEPELKDYKCEVTSGTLRIGAVSAPIYNAHEKMKVPDVLFYDNIQHVIVMEDM LKDFLLGEHLLLVGNQGVGKNKIVDRFLHLLNRPREYIQLHRDTTVQTLTLQPSVKDGLIVYEDSPLVKAVKLGHILVVDEADKAPTNVT CILKTLVENGEMILADGRRIVANSANVNGRENVVVIHPDFRMIVLANRPGFPFLGNDFFGTLGDIFSCHAVDNPKPHSELEMLRQYGPNV PEPILQKLVAAFGELRSLADQGIINYPYSTREVVNIVKHLQKFPTEGLSSVVRNVFDFDSYNNDMREILINTLHKYGIPIGAKPTSVQLA -------------------------------------------------------------- >26163_26163_4_ELF1-VWA8_ELF1_chr13_41556119_ENST00000442101_VWA8_chr13_42465723_ENST00000379310_length(transcript)=6895nt_BP=300nt GCCAAGAAGCTTGAGAGAAGAAAAATTTCAGAAAAATTGTCTCAATTTGACTAGAATATCAATGAACCAGGAAAACTGAAGCACCTTCCC TAAAGAAAACTTGGGTATACAATTACTCCACAGACAGAGCTGAGGGTTTTTTACCCAAATCAGTCACTGGATTTTGCTGCCTGATACGTG AATCTTCTTGGAATTTTTCTCATGTGGATCTAAGGGGAATGCTTTATTATGGCTGCTGTTGTCCAACAGAACGACCTAGTATTTGAATTT GCTAGTAACGTCATGGAGGATGAACGACAGTGTGCAGTTCGTGCAGCCACAGAAGGCAGAACTCTCATTTTGGAAGGTTTGGAAAAGGCA GAGAGGAATGTTTTGCCTGTTTTGAACAACTTGCTGGAAAACAGAGAGATGCAGCTTGAAGATGGACGCTTCCTGATGTCTGCTGAGCGT TACGACAAACTTCTCCGAGATCATACCAAAAAAGAGTTGGATTCTTGGAAAATTGTCCGAGTTAGTGAAAATTTCCGAGTGATTGCCTTG GGCTTGCCAGTGCCAAGGTATTCTGGGAATCCATTAGACCCCCCTCTTCGTTCTCGATTTCAAGCCAGGGATATTTATTATTTACCCTTC AAGGACCAACTTAAGTTGTTATATTCAATTGGAGCCAATGTTTCTGCTGAGAAAGTTTCTCAGCTCTTGTCCTTTGCCACAACTCTGTGT TCCCAAGAATCTTCTACTCTTGGACTTCCAGACTTTCCTTTAGATAGTTTAGCAGCTGCGGTTCAAATCTTGGATTCCTTTCCTATGATG CCAATCAAACATGCAATCCAGTGGCTTTATCCATATAGTATTTTACTAGGTCATGAAGGGAAGATGGCTGTGGAAGGTGTTTTAAAGCGC TTTGAACTTCAAGATTCAGGAAGCTCTCTACTTCCTAAAGAGATTGTAAAAGTAGAGAAGATGATGGAAAACCATGTGTCCCAAGCTTCT GTGACCATCCGGATTGCAGATAAAGAGGTGACCATTAAGGTGCCAGCCGGGACCAGGCTATTAAGTCAACCTTGTGCGTCAGACCGTTTC ATACAGACTTTGAGCCATAAGCAGCTACAGGCTGAAATGATGCAGTCTCACATGGTTAAAGATATATGTTTAATTGGAGGAAAGGGTTGT GGAAAAACAGTGATCGCTAAGAACTTTGCCGATACCTTAGGATACAACATAGAACCTATTATGCTCTATCAGGATATGACAGCGCGTGAT CTGCTACAGCAGAGATACACCCTTCCAAATGGAGACACTGCCTGGCGGTCCTCACCCCTTGTGAATGCTGCTCTGGAAGGCAAGCTGGTC CTGCTGGATGGCATTCACCGGGTGAATGCGGGCACGCTTGCTGTATTGCAAAGGTTAATCCATGATCGAGAGCTAAGCCTCTATGATGGT TCTAGGCTGCTGAGAGAAGACAGGTATATGCGTTTAAAGGAGGAGCTGCAACTGTCTGATGAACAGCTACAGAAGAGATCCATTTTTCCT ATCCATCCCTCCTTCAGAATCATTGCCTTGGCAGAACCCCCTGTTATTGGAAGCACAGCACACCAGTGGCTGGGACCAGAATTCTTAACC ATGTTCTTTTTCCATTACATGAAACCACTTGTGAAAAGTGAAGAAATCCAAGTGATTAAGGAAAAGGTCCCAAATGTACCTCAGGAAGCT CTGGATAAGTTATTATCATTTACACACAAACTCAGAGAAACACAGGATCCAACGGCACAATCATTAGCGGCATCACTTTCTACCAGACAA CTGTTGCGAATTTCTCGTCGGCTGTCACAGTATCCTAATGAAAATCTTCACAGTGCTGTTACTAAAGCCTGCCTTTCCAGGTTTTTACCC AGTCTTGCTAGGTCAGCATTAGAAAAAAATCTGGCAGATGCTACAATAGAAATAAATACTGATGACAATTTGGAGCCAGAACTGAAGGAT TACAAATGTGAAGTAACATCTGGAACTCTGAGGATTGGTGCTGTTAGTGCACCGATCTATAATGCACATGAGAAAATGAAAGTGCCTGAT GTTCTTTTCTATGACAACATTCAGCATGTGATAGTGATGGAAGATATGCTGAAAGACTTTCTCCTTGGAGAACACTTATTATTGGTTGGC AACCAGGGTGTAGGAAAAAACAAGATTGTTGACAGATTCCTTCACCTGCTCAACAGACCCCGAGAATATATTCAGCTACACAGGGATACC ACAGTACAAACTCTTACGCTTCAGCCTTCGGTTAAAGACGGACTTATTGTATATGAAGACTCACCTTTGGTTAAAGCAGTAAAGTTGGGT CATATTCTGGTAGTAGATGAGGCTGACAAAGCTCCAACAAATGTCACGTGTATTTTAAAAACTCTAGTAGAAAATGGAGAAATGATTCTA GCAGATGGAAGACGCATTGTTGCAAATTCTGCTAATGTGAATGGAAGAGAAAATGTTGTAGTGATTCATCCTGATTTTAGGATGATTGTT CTGGCAAATAGACCTGGATTTCCTTTCCTAGGCAATGATTTCTTCGGTACCTTAGGTGATATTTTTAGCTGCCATGCAGTTGATAACCCC AAACCCCACTCGGAGCTCGAGATGCTCAGACAGTATGGACCAAATGTGCCTGAGCCCATCCTTCAGAAGCTTGTGGCTGCCTTTGGAGAG CTGAGGAGTTTGGCTGACCAAGGGATTATTAACTATCCTTATTCTACCAGAGAAGTTGTCAACATAGTCAAACATTTACAGAAATTTCCG ACTGAAGGTCTCTCCAGTGTAGTTCGAAATGTGTTTGACTTTGATTCCTACAACAATGACATGAGGGAGATATTGATTAACACTTTACAC AAATACGGGATACCTATCGGAGCAAAGCCTACCAGTGTGCAGCTGGCAAAGGAGTTGACTCTGCCAGAACAAACGTTCATGGGCTACTGG ACAATTGGTCAGGCAAGAAGTGGGATGCAAAAACTCTTGTGTCCAGTGGAAACTCATCATATAGACATAAAGGGTCCAGCACTTATAAAT ATACAGGAGTATCCAATAGAAAGACATGAAGAAAGATCCCTAAACTTTACTGAAGAATGTGCCTCATGGAGAATACCATTGGATGAAATT AATATAATCTGTGACATTGCTACATCACATGAAAATGAGCAAAATACTCTCTATGTAGTTACATGCAATCCCGCTTCCCTGTACTTTATG AATATGACTGGGAAAAGTGGCTTCTTTGTGGACTTTTTTGATATCTTCCCAAGAACAGCCAATGGCGTTTGGCACCCTTTTGTGACAGTG GCACCGCTGGGAAGTCCTCTCAAAGGTCAAGTGGTTCTCCATGAGCAGCAGAGTAATGTTATCCTGTTGTTAGATACTACTGGCCGGGCC CTTCATCGTCTCATCCTCCCTTCCGAGAAGTTTACATCTAAGAAACCTTTCTGGTGGAACAAAGAAGAAGCTGAAACTTATAAAATGTGT AAAGAATTTTCACACAAAAACTGGCTGGTGTTCTACAAAGAAAAAGGGAACAGCCTGACTGTGCTGGATGTTCTAGAAGGGCGAACTCAC ACCATCTCACTTCCCATCAACCTCAAGACAGTTTTCCTTGTAGCAGAGGACAAATGGCTTCTGGTGGAGAGCAAAACAAATCAGAAATAT CTTTTAACTAAGCCTGCACACATCGAATCTGAGGGTAGTGGGGTTTGCCAGTTGTATGTGCTGAAAGAGGAGCCGCCCAGCACAGGGTTT GGAGTTACACAAGAAACAGAGTTCAGCATACCTCATAAAATTTCCAGTGATCAACTATCATCTGAACATCTAAGTTCAGCTGTGGAACAA AAGATTGCCTCTCCCAACAGAATTCTCTCAGATGAGAAAAATTATGCTACAATAGTTGTTGGTTTTCCAGATCTCATGTCACCCAGTGAA GTTTATTCTTGGAAGAGACCATCATCTTTGCATAAACGAAGTGGCACTGATACATCATTCTATAGAGGAAAGAAGAAAAGGGGGACTCCA AAACAAAGCAATTGTGTGACTCTTTTAGATACGAATCAGGTAGTGAGGATTTTACCCCCAGGAGAAGTCCCTCTAAAAGATATCTACCCA AAAGATGTTACTCCTCCACAAACATCTGGTTATATAGAAGTCACTGATCTTCAATCAAAGAAACTCCGATATATCCCTATTCCCAGATCA GAATCTCTCTCGCCGTATACCACATGGCTGTCGACCATTTCAGACACAGATGCACTGCTGGCTGAGTGGGACAAAAGCGGTGTTGTTACT GTTGATATGGGAGGTCACATCAGGCTTTGGGAAACTGGACTTGAACGTCTGCAGCGATCACTCATGGAATGGAGAAACATGATTGGACAA GATGACAGAAATATGCAGATAACAATCAACAGAGACAGTGGTGAAGATGTAAGCTCCCCCAAACACGGGAAGGAGGACCCAGACAACATG CCTCACGTGGGCGGCAACACTTGGGCTGGCGGAACAGGGGGAAGAGACACGGCAGGCCTGGGTGGCAAAGGAGGCCCTTACCGGCTGGAT GCAGGCCATACGGTGTACCAGGTCTCTCAGGCTGAGAAAGATGCAGTTCCCGAAGAGGTCAAGAGAGCTGCTAGAGAGATGGGCCAGAGA GCATTCCAGCAGAGGCTAAAGGAGATCCAAATGAGTGAATACGATGCTGCAACCTATGAAAGGTTTTCAGGTGCTGTTCGGCGACAGGTG CACTCCCTCCGAATCATCCTGGATAATTTACAGGCTAAAGGTAAAGAAAGACAATGGCTAAGACATCAAGCTACTGGAGAATTAGATGAT GCCAAGATCATTGATGGGCTGACTGGAGAAAAAGCCATCTACAAACGTCGGGGTGAGCTGGAGCCACAACTTGGCAGCCCACAACAGAAA CCCAAGCGTCTGCGCCTGGTGGTAGATGTGTCTGGTAGCATGTACCGTTTCAACAGGATGGATGGCCGGCTTGAGCGCACAATGGAGGCT GTGTGTATGGTCATGGAAGCCTTCGAGAACTATGAGGAGAAGTTCCAGTATGACATCGTTGGACACTCTGGAGATGGCTACAACATTGGT CTGGTTCCAATGAACAAAATCCCCAAGGACAATAAGCAAAGACTAGAAATTCTGAAGACAATGCATGCCCACTCTCAGTTCTGCATGAGT GGGGACCACACGTTAGAAGGGACAGAACATGCCATCAAGGAAATTGTCAAAGAAGAAGCTGATGAGTACTTTGTCATAGTCTTGAGTGAT GCAAATCTGTCACGATATGGAATACATCCTGCTAAGTTTGCTCAAATCCTCACAAGAGACCCTCAAGTAAATGCTTTTGCCATTTTTATT GGCTCTTTAGGTGATCAAGCAACCAGGCTTCAGAGAACTTTACCAGCTGGTCGGTCTTTCGTTGCCATGGATACCAAGGATATCCCTCAG ATTTTACAACAGATCTTCACCTCCACCATGTTGTCGAGTGTCTAAGAAGTGCCCTTCATCACCCTGATGACACCAGGATTTGAAATAAGA CAGGAATAAAGAGTATTCTGAAAAAAAGAAGATATGGATGAAGTGAACCCATGCAGTGACTGGATGATTCCGGCATTCCTGGGTCTTCCT ACACTTGCTCCGTAATGAGAATTCAGAGAAGCAGCCAGAAGGAGACTTAAACATGGAAAGATACTCCACTGATGAGTTTAGAAGTGATTA GGGCAAGCTAGTTGACCTGCACTTTATCAAAGGTTGGGGTTAAAGGAAGGTGGTTTTGAGAACTATGTGTTTGGTCTATTTCCAAAAACC TGAGGGGGAGAAAATACTTTGCTTTTGCCTTAACACATCATCTGGTCACGTTAGAAAAGTGACCCCATCAAACTGAGCCTTTGATGTCAC ATTCTGACACAAGATGCAAGTCTGTGCAAAACCCACCAAAATGCTCCTATCCAACAATTATTTTTATTTTCTCCCTGCTCTGTATTGACC AGAAAACAATGATTTTATAATATTTAACCCACCAAAAAGTCCCTCCAACAGCAATATCTTATGAAAGTCTGGCTGTTCTCAATAATTTCA TTTTCTTGGCCAAAGCCAAAAGGAATCAAAAAATCCTTGGAGTGCTTGCCTTTCCACGTGACTTTTAAAAGGCTCTTAAAGAGCAAATGT CCTCTTCTCCTTGCTGCTAGAGTGGGAGGAGAAAGATGTCTTGCCTTAAAAGTTTACTGTTTCTTCTGTTCTTCTAGCATCTCTCAAAAA ATTCACAGTACTCCATTTTGGGGTCCAAACTGTAATGCTCAAAATAATAAATGCTTACACGAAAATTATTTATTGAGAATATTCATATAA AAATTACCTAAAGCAAAGTAAAAAAAGTAAAATCAAGGTGGTATATTTGAAGTGAATGGTGATTGGAAATTTTTAGCTGTAACAAAAAGA AAGAAAACAACTTTTTTTAAAGCCTCATTCTCTTTTCTTTCAAAATGTACCTTATTCCCACACACTCTTGGGCTGACCTTTATTTTATCA ATAAGCTCAATATTACTTTGTTTAAAATAAGATGCTTCAGCAAAAGTCATTCTCTCTTTAACCATATAATTTAAAAACTCCTCTTCACGA TTGATAGCAAAATCAGAAACGTTAGGGCACCAGTGAGTTGAAAAAACTGGTCTTAAGTTGGAAAAACTATTATTAATAATATTATCCTAT CCATCCATATCTATTGAAATTGTACAGGTCCATAATTTCATTTTAATTAATTATAGGAAAGAAGAAAAGATAATACCCATTTGTTCTATC >26163_26163_4_ELF1-VWA8_ELF1_chr13_41556119_ENST00000442101_VWA8_chr13_42465723_ENST00000379310_length(amino acids)=1768AA_BP=24 MAAVVQQNDLVFEFASNVMEDERQCAVRAATEGRTLILEGLEKAERNVLPVLNNLLENREMQLEDGRFLMSAERYDKLLRDHTKKELDSW KIVRVSENFRVIALGLPVPRYSGNPLDPPLRSRFQARDIYYLPFKDQLKLLYSIGANVSAEKVSQLLSFATTLCSQESSTLGLPDFPLDS LAAAVQILDSFPMMPIKHAIQWLYPYSILLGHEGKMAVEGVLKRFELQDSGSSLLPKEIVKVEKMMENHVSQASVTIRIADKEVTIKVPA GTRLLSQPCASDRFIQTLSHKQLQAEMMQSHMVKDICLIGGKGCGKTVIAKNFADTLGYNIEPIMLYQDMTARDLLQQRYTLPNGDTAWR SSPLVNAALEGKLVLLDGIHRVNAGTLAVLQRLIHDRELSLYDGSRLLREDRYMRLKEELQLSDEQLQKRSIFPIHPSFRIIALAEPPVI GSTAHQWLGPEFLTMFFFHYMKPLVKSEEIQVIKEKVPNVPQEALDKLLSFTHKLRETQDPTAQSLAASLSTRQLLRISRRLSQYPNENL HSAVTKACLSRFLPSLARSALEKNLADATIEINTDDNLEPELKDYKCEVTSGTLRIGAVSAPIYNAHEKMKVPDVLFYDNIQHVIVMEDM LKDFLLGEHLLLVGNQGVGKNKIVDRFLHLLNRPREYIQLHRDTTVQTLTLQPSVKDGLIVYEDSPLVKAVKLGHILVVDEADKAPTNVT CILKTLVENGEMILADGRRIVANSANVNGRENVVVIHPDFRMIVLANRPGFPFLGNDFFGTLGDIFSCHAVDNPKPHSELEMLRQYGPNV PEPILQKLVAAFGELRSLADQGIINYPYSTREVVNIVKHLQKFPTEGLSSVVRNVFDFDSYNNDMREILINTLHKYGIPIGAKPTSVQLA KELTLPEQTFMGYWTIGQARSGMQKLLCPVETHHIDIKGPALINIQEYPIERHEERSLNFTEECASWRIPLDEINIICDIATSHENEQNT LYVVTCNPASLYFMNMTGKSGFFVDFFDIFPRTANGVWHPFVTVAPLGSPLKGQVVLHEQQSNVILLLDTTGRALHRLILPSEKFTSKKP FWWNKEEAETYKMCKEFSHKNWLVFYKEKGNSLTVLDVLEGRTHTISLPINLKTVFLVAEDKWLLVESKTNQKYLLTKPAHIESEGSGVC QLYVLKEEPPSTGFGVTQETEFSIPHKISSDQLSSEHLSSAVEQKIASPNRILSDEKNYATIVVGFPDLMSPSEVYSWKRPSSLHKRSGT DTSFYRGKKKRGTPKQSNCVTLLDTNQVVRILPPGEVPLKDIYPKDVTPPQTSGYIEVTDLQSKKLRYIPIPRSESLSPYTTWLSTISDT DALLAEWDKSGVVTVDMGGHIRLWETGLERLQRSLMEWRNMIGQDDRNMQITINRDSGEDVSSPKHGKEDPDNMPHVGGNTWAGGTGGRD TAGLGGKGGPYRLDAGHTVYQVSQAEKDAVPEEVKRAAREMGQRAFQQRLKEIQMSEYDAATYERFSGAVRRQVHSLRIILDNLQAKGKE RQWLRHQATGELDDAKIIDGLTGEKAIYKRRGELEPQLGSPQQKPKRLRLVVDVSGSMYRFNRMDGRLERTMEAVCMVMEAFENYEEKFQ YDIVGHSGDGYNIGLVPMNKIPKDNKQRLEILKTMHAHSQFCMSGDHTLEGTEHAIKEIVKEEADEYFVIVLSDANLSRYGIHPAKFAQI -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ELF1-VWA8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | VWA8 | chr13:41556119 | chr13:42465723 | ENST00000281496 | 3 | 26 | 1_261 | 161.0 | 1040.0 | PEX7 | |
| Tgene | VWA8 | chr13:41556119 | chr13:42465723 | ENST00000379310 | 3 | 45 | 1_261 | 161.0 | 1906.0 | PEX7 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ELF1-VWA8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ELF1-VWA8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C0004352 | Autistic Disorder | 1 | CTD_human |
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