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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:A1BG-ITIH4 (FusionGDB2 ID:HG1TG3700)

Fusion Gene Summary for A1BG-ITIH4

check button Fusion gene summary
Fusion gene informationFusion gene name: A1BG-ITIH4
Fusion gene ID: hg1tg3700
HgeneTgene
Gene symbol

A1BG

ITIH4

Gene ID

1

3700

Gene namealpha-1-B glycoproteininter-alpha-trypsin inhibitor heavy chain 4
SynonymsA1B|ABG|GAB|HYST2477GP120|H4P|IHRP|ITI-HC4|ITIHL1|PK-120|PK120
Cytomap('A1BG')('ITIH4')

19q13.43

3p21.1

Type of geneprotein-codingprotein-coding
Descriptionalpha-1B-glycoproteinHEL-S-163pAepididymis secretory sperm binding protein Li 163pAinter-alpha-trypsin inhibitor heavy chain H4ITI heavy chain H4inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)inter-alpha-inhibitor heavy chain 4inter-alpha-trypsin inhibitor family heavy chain-related proteininter-alpha
Modification date2020031320200320
UniProtAcc

P04217

.
Ensembl transtripts involved in fusion geneENST00000263100, ENST00000596924, 
Fusion gene scores* DoF score3 X 3 X 2=187 X 6 X 3=126
# samples 37
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: A1BG [Title/Abstract] AND ITIH4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointA1BG(58862757)-ITIH4(52852299), # samples:8
Anticipated loss of major functional domain due to fusion event.A1BG-ITIH4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
A1BG-ITIH4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
A1BG-ITIH4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
A1BG-ITIH4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across A1BG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ITIH4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-BC-A10Q-11AA1BGchr19

58862757

-ITIH4chr3

52852299

-
ChimerDB4Non-CancerTCGA-BC-A110-11AA1BGchr19

58862757

-ITIH4chr3

52852299

-
ChimerDB4Non-CancerTCGA-BD-A2L6-11AA1BGchr19

58862757

-ITIH4chr3

52852299

-
ChimerDB4Non-CancerTCGA-DD-A116-11AA1BGchr19

58862757

-ITIH4chr3

52852299

-
ChimerDB4Non-CancerTCGA-DD-A1EE-11AA1BGchr19

58862757

-ITIH4chr3

52852299

-
ChimerDB4Non-CancerTCGA-DD-A39Z-11AA1BGchr19

58862757

-ITIH4chr3

52852299

-
ChimerDB4Non-CancerTCGA-ES-A2HT-11AA1BGchr19

58862757

-ITIH4chr3

52852299

-
ChimerDB4Non-CancerTCGA-FV-A3I1-11AA1BGchr19

58862757

-ITIH4chr3

52852299

-


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Fusion Gene ORF analysis for A1BG-ITIH4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263100ENST00000434759A1BGchr19

58862757

-ITIH4chr3

52852299

-
5CDS-intronENST00000263100ENST00000467462A1BGchr19

58862757

-ITIH4chr3

52852299

-
In-frameENST00000263100ENST00000266041A1BGchr19

58862757

-ITIH4chr3

52852299

-
In-frameENST00000263100ENST00000346281A1BGchr19

58862757

-ITIH4chr3

52852299

-
In-frameENST00000263100ENST00000406595A1BGchr19

58862757

-ITIH4chr3

52852299

-
In-frameENST00000263100ENST00000485816A1BGchr19

58862757

-ITIH4chr3

52852299

-
intron-3CDSENST00000596924ENST00000266041A1BGchr19

58862757

-ITIH4chr3

52852299

-
intron-3CDSENST00000596924ENST00000346281A1BGchr19

58862757

-ITIH4chr3

52852299

-
intron-3CDSENST00000596924ENST00000406595A1BGchr19

58862757

-ITIH4chr3

52852299

-
intron-3CDSENST00000596924ENST00000485816A1BGchr19

58862757

-ITIH4chr3

52852299

-
intron-intronENST00000596924ENST00000434759A1BGchr19

58862757

-ITIH4chr3

52852299

-
intron-intronENST00000596924ENST00000467462A1BGchr19

58862757

-ITIH4chr3

52852299

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000263100A1BGchr1958862757-ENST00000266041ITIH4chr352852299-205997281612534
ENST00000263100A1BGchr1958862757-ENST00000346281ITIH4chr352852299-208697281654548
ENST00000263100A1BGchr1958862757-ENST00000485816ITIH4chr352852299-176497281612534
ENST00000263100A1BGchr1958862757-ENST00000406595ITIH4chr352852299-175297281612534

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263100ENST00000266041A1BGchr1958862757-ITIH4chr352852299-0.045431540.95456845
ENST00000263100ENST00000346281A1BGchr1958862757-ITIH4chr352852299-0.064497320.9355027
ENST00000263100ENST00000485816A1BGchr1958862757-ITIH4chr352852299-0.0515728260.9484272
ENST00000263100ENST00000406595A1BGchr1958862757-ITIH4chr352852299-0.053453210.9465468

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Fusion Genomic Features for A1BG-ITIH4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for A1BG-ITIH4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:58862757/chr3:52852299)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
A1BG

P04217

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneA1BGchr19:58862757chr3:52852299ENST00000263100-58114_206303496.0DomainNote=Ig-like V-type 2
HgeneA1BGchr19:58862757chr3:52852299ENST00000263100-58207_299303496.0DomainNote=Ig-like V-type 3
HgeneA1BGchr19:58862757chr3:52852299ENST00000263100-5822_113303496.0DomainNote=Ig-like V-type 1
TgeneITIH4chr19:58862757chr3:52852299ENST000002660411724719_725717931.0RegionNote=O-glycosylated at three sites
TgeneITIH4chr19:58862757chr3:52852299ENST000003462811522719_725687915.0RegionNote=O-glycosylated at three sites
TgeneITIH4chr19:58862757chr3:52852299ENST000004065951522719_725687901.0RegionNote=O-glycosylated at three sites

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneA1BGchr19:58862757chr3:52852299ENST00000263100-58300_397303496.0DomainNote=Ig-like V-type 4
HgeneA1BGchr19:58862757chr3:52852299ENST00000263100-58398_495303496.0DomainNote=Ig-like V-type 5
TgeneITIH4chr19:58862757chr3:52852299ENST000002660411724272_432717931.0DomainVWFA
TgeneITIH4chr19:58862757chr3:52852299ENST00000266041172429_148717931.0DomainVIT
TgeneITIH4chr19:58862757chr3:52852299ENST000003462811522272_432687915.0DomainVWFA
TgeneITIH4chr19:58862757chr3:52852299ENST00000346281152229_148687915.0DomainVIT
TgeneITIH4chr19:58862757chr3:52852299ENST000004065951522272_432687901.0DomainVWFA
TgeneITIH4chr19:58862757chr3:52852299ENST00000406595152229_148687901.0DomainVIT
TgeneITIH4chr19:58862757chr3:52852299ENST000002660411724658_688717931.0RegionNote=Proline-rich (PRR) potential bioactive peptide
TgeneITIH4chr19:58862757chr3:52852299ENST000003462811522658_688687915.0RegionNote=Proline-rich (PRR) potential bioactive peptide
TgeneITIH4chr19:58862757chr3:52852299ENST000004065951522658_688687901.0RegionNote=Proline-rich (PRR) potential bioactive peptide


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Fusion Gene Sequence for A1BG-ITIH4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4_4_1_A1BG-ITIH4_A1BG_chr19_58862757_ENST00000263100_ITIH4_chr3_52852299_ENST00000266041_length(transcript)=2059nt_BP=972nt
GGGCCTCATTGCTGCAGACGCTCACCCCAGACACTCACTGCACCGGAGTGAGCGCGACCATCATGTCCATGCTCGTGGTCTTTCTCTTGC
TGTGGGGTGTCACCTGGGGCCCAGTGACAGAAGCAGCCATATTTTATGAGACGCAGCCCAGCCTGTGGGCAGAGTCCGAATCACTGCTGA
AACCCTTGGCCAATGTGACGCTGACGTGCCAGGCCCACCTGGAGACTCCAGACTTCCAGCTGTTCAAGAATGGGGTGGCCCAGGAGCCTG
TGCACCTTGACTCACCTGCCATCAAGCACCAGTTCCTGCTGACGGGTGACACCCAGGGCCGCTACCGCTGCCGCTCGGGCTTGTCCACAG
GATGGACCCAGCTGAGCAAGCTCCTGGAGCTGACAGGGCCAAAGTCCTTGCCTGCTCCCTGGCTCTCGATGGCGCCAGTGTCCTGGATCA
CCCCCGGCCTGAAAACAACAGCAGTGTGCCGAGGTGTGCTGCGGGGTGTGACTTTTCTGCTGAGGCGGGAGGGCGACCATGAGTTTCTGG
AGGTGCCTGAGGCCCAGGAGGATGTGGAGGCCACCTTTCCAGTCCATCAGCCTGGCAACTACAGCTGCAGCTACCGGACCGATGGGGAAG
GCGCCCTCTCTGAGCCCAGCGCTACTGTGACCATTGAGGAGCTCGCTGCACCACCACCGCCTGTGCTGATGCACCATGGAGAGTCCTCCC
AGGTCCTGCACCCTGGCAACAAGGTGACCCTCACCTGCGTGGCTCCCCTGAGTGGAGTGGACTTCCAGCTACGGCGCGGGGAGAAAGAGC
TGCTGGTACCCAGGAGCAGCACCAGCCCAGATCGCATCTTCTTTCACCTGAACGCGGTGGCCCTGGGGGATGGAGGTCACTACACCTGCC
GCTACCGGCTGCATGACAACCAAAACGGCTGGTCCGGGGACAGCGCGCCGGTCGAGCTGATTCTGAGCGATGAAACAACCATGACAACCC
AAACCCCAGCCCCCATACAGGCTCCCTCTGCCATCCTGCCACTGCCTGGGCAGAGTGTGGAGCGGCTCTGTGTGGACCCCAGACACCGCC
AGGGGCCAGTGAACCTGCTCTCAGACCCTGAGCAAGGGGTTGAGGTGACTGGCCAGTATGAGAGGGAGAAGGCTGGGTTCTCATGGATCG
AAGTGACCTTCAAGAACCCCCTGGTATGGGTTCACGCATCCCCTGAACACGTGGTGGTGACTCGGAACCGAAGAAGCTCTGCGTACAAGT
GGAAGGAGACGCTATTCTCAGTGATGCCCGGCCTGAAGATGACCATGGACAAGACGGGTCTCCTGCTGCTCAGTGACCCAGACAAAGTGA
CCATCGGCCTGTTGTTCTGGGATGGCCGTGGGGAGGGGCTCCGGCTCCTTCTGCGTGACACTGACCGCTTCTCCAGCCACGTTGGAGGGA
CCCTTGGCCAGTTTTACCAGGAGGTGCTCTGGGGATCTCCAGCAGCATCAGATGACGGCAGACGCACGCTGAGGGTTCAGGGCAATGACC
ACTCTGCCACCAGAGAGCGCAGGCTGGATTACCAGGAGGGGCCCCCGGGAGTGGAGATTTCCTGCTGGTCTGTGGAGCTGTAGTTCTGAT
GGAAGGAGCTGTGCCCACCCTGTACACTTGGCTTCCCCCTGCAACTGCAGGGCCGCTTCTGGGGCCTGGACCACCATGGGGAGGAAGAGT
CCCACTCATTACAAATAAAGAAAGGTGGTGTGAGCCTGGGAAGTGGGTGTCTCCAGTTCCATGTGGCCAAATCCTAGGGCCTCAACCTCG
CATCCTGAACCTTAGCATCGTGGAACACAGAAGCTTCCACTGTCAGCTCTCAAGAGCCCATGGCCAGGAAGGCCCATGCTGAGCTTTCAG
TCCAGCCCCTTCATTTTACAAACAAGGAAACTGAGCTCGAACCACCCATTTGAGATGTCACTGTGGCCCCCAGCTAGAGGCCCAGGGCTG

>4_4_1_A1BG-ITIH4_A1BG_chr19_58862757_ENST00000263100_ITIH4_chr3_52852299_ENST00000266041_length(amino acids)=534AA_BP=316
MLQTLTPDTHCTGVSATIMSMLVVFLLLWGVTWGPVTEAAIFYETQPSLWAESESLLKPLANVTLTCQAHLETPDFQLFKNGVAQEPVHL
DSPAIKHQFLLTGDTQGRYRCRSGLSTGWTQLSKLLELTGPKSLPAPWLSMAPVSWITPGLKTTAVCRGVLRGVTFLLRREGDHEFLEVP
EAQEDVEATFPVHQPGNYSCSYRTDGEGALSEPSATVTIEELAAPPPPVLMHHGESSQVLHPGNKVTLTCVAPLSGVDFQLRRGEKELLV
PRSSTSPDRIFFHLNAVALGDGGHYTCRYRLHDNQNGWSGDSAPVELILSDETTMTTQTPAPIQAPSAILPLPGQSVERLCVDPRHRQGP
VNLLSDPEQGVEVTGQYEREKAGFSWIEVTFKNPLVWVHASPEHVVVTRNRRSSAYKWKETLFSVMPGLKMTMDKTGLLLLSDPDKVTIG

--------------------------------------------------------------
>4_4_2_A1BG-ITIH4_A1BG_chr19_58862757_ENST00000263100_ITIH4_chr3_52852299_ENST00000346281_length(transcript)=2086nt_BP=972nt
GGGCCTCATTGCTGCAGACGCTCACCCCAGACACTCACTGCACCGGAGTGAGCGCGACCATCATGTCCATGCTCGTGGTCTTTCTCTTGC
TGTGGGGTGTCACCTGGGGCCCAGTGACAGAAGCAGCCATATTTTATGAGACGCAGCCCAGCCTGTGGGCAGAGTCCGAATCACTGCTGA
AACCCTTGGCCAATGTGACGCTGACGTGCCAGGCCCACCTGGAGACTCCAGACTTCCAGCTGTTCAAGAATGGGGTGGCCCAGGAGCCTG
TGCACCTTGACTCACCTGCCATCAAGCACCAGTTCCTGCTGACGGGTGACACCCAGGGCCGCTACCGCTGCCGCTCGGGCTTGTCCACAG
GATGGACCCAGCTGAGCAAGCTCCTGGAGCTGACAGGGCCAAAGTCCTTGCCTGCTCCCTGGCTCTCGATGGCGCCAGTGTCCTGGATCA
CCCCCGGCCTGAAAACAACAGCAGTGTGCCGAGGTGTGCTGCGGGGTGTGACTTTTCTGCTGAGGCGGGAGGGCGACCATGAGTTTCTGG
AGGTGCCTGAGGCCCAGGAGGATGTGGAGGCCACCTTTCCAGTCCATCAGCCTGGCAACTACAGCTGCAGCTACCGGACCGATGGGGAAG
GCGCCCTCTCTGAGCCCAGCGCTACTGTGACCATTGAGGAGCTCGCTGCACCACCACCGCCTGTGCTGATGCACCATGGAGAGTCCTCCC
AGGTCCTGCACCCTGGCAACAAGGTGACCCTCACCTGCGTGGCTCCCCTGAGTGGAGTGGACTTCCAGCTACGGCGCGGGGAGAAAGAGC
TGCTGGTACCCAGGAGCAGCACCAGCCCAGATCGCATCTTCTTTCACCTGAACGCGGTGGCCCTGGGGGATGGAGGTCACTACACCTGCC
GCTACCGGCTGCATGACAACCAAAACGGCTGGTCCGGGGACAGCGCGCCGGTCGAGCTGATTCTGAGCGATGAAACAACCATGACAACCC
AAACCCCAGCCTGCCCTTCCTGCTCCAGGAGCCGTGCCCCGGCTGTCCCAGCCCCCATACAGGCTCCCTCTGCCATCCTGCCACTGCCTG
GGCAGAGTGTGGAGCGGCTCTGTGTGGACCCCAGACACCGCCAGGGGCCAGTGAACCTGCTCTCAGACCCTGAGCAAGGGGTTGAGGTGA
CTGGCCAGTATGAGAGGGAGAAGGCTGGGTTCTCATGGATCGAAGTGACCTTCAAGAACCCCCTGGTATGGGTTCACGCATCCCCTGAAC
ACGTGGTGGTGACTCGGAACCGAAGAAGCTCTGCGTACAAGTGGAAGGAGACGCTATTCTCAGTGATGCCCGGCCTGAAGATGACCATGG
ACAAGACGGGTCTCCTGCTGCTCAGTGACCCAGACAAAGTGACCATCGGCCTGTTGTTCTGGGATGGCCGTGGGGAGGGGCTCCGGCTCC
TTCTGCGTGACACTGACCGCTTCTCCAGCCACGTTGGAGGGACCCTTGGCCAGTTTTACCAGGAGGTGCTCTGGGGATCTCCAGCAGCAT
CAGATGACGGCAGACGCACGCTGAGGGTTCAGGGCAATGACCACTCTGCCACCAGAGAGCGCAGGCTGGATTACCAGGAGGGGCCCCCGG
GAGTGGAGATTTCCTGCTGGTCTGTGGAGCTGTAGTTCTGATGGAAGGAGCTGTGCCCACCCTGTACACTTGGCTTCCCCCTGCAACTGC
AGGGCCGCTTCTGGGGCCTGGACCACCATGGGGAGGAAGAGTCCCACTCATTACAAATAAAGAAAGGTGGTGTGAGCCTGGGAAGTGGGT
GTCTCCAGTTCCATGTGGCCAAATCCTAGGGCCTCAACCTCGCATCCTGAACCTTAGCATCGTGGAACACAGAAGCTTCCACTGTCAGCT
CTCAAGAGCCCATGGCCAGGAAGGCCCATGCTGAGCTTTCAGTCCAGCCCCTTCATTTTACAAACAAGGAAACTGAGCTCGAACCACCCA
TTTGAGATGTCACTGTGGCCCCCAGCTAGAGGCCCAGGGCTGGGAGCATTCTCCAGGAGCAGAGGTTCAGTCTGCTTCATGGTCTCTTGG

>4_4_2_A1BG-ITIH4_A1BG_chr19_58862757_ENST00000263100_ITIH4_chr3_52852299_ENST00000346281_length(amino acids)=548AA_BP=316
MLQTLTPDTHCTGVSATIMSMLVVFLLLWGVTWGPVTEAAIFYETQPSLWAESESLLKPLANVTLTCQAHLETPDFQLFKNGVAQEPVHL
DSPAIKHQFLLTGDTQGRYRCRSGLSTGWTQLSKLLELTGPKSLPAPWLSMAPVSWITPGLKTTAVCRGVLRGVTFLLRREGDHEFLEVP
EAQEDVEATFPVHQPGNYSCSYRTDGEGALSEPSATVTIEELAAPPPPVLMHHGESSQVLHPGNKVTLTCVAPLSGVDFQLRRGEKELLV
PRSSTSPDRIFFHLNAVALGDGGHYTCRYRLHDNQNGWSGDSAPVELILSDETTMTTQTPACPSCSRSRAPAVPAPIQAPSAILPLPGQS
VERLCVDPRHRQGPVNLLSDPEQGVEVTGQYEREKAGFSWIEVTFKNPLVWVHASPEHVVVTRNRRSSAYKWKETLFSVMPGLKMTMDKT
GLLLLSDPDKVTIGLLFWDGRGEGLRLLLRDTDRFSSHVGGTLGQFYQEVLWGSPAASDDGRRTLRVQGNDHSATRERRLDYQEGPPGVE

--------------------------------------------------------------
>4_4_3_A1BG-ITIH4_A1BG_chr19_58862757_ENST00000263100_ITIH4_chr3_52852299_ENST00000406595_length(transcript)=1752nt_BP=972nt
GGGCCTCATTGCTGCAGACGCTCACCCCAGACACTCACTGCACCGGAGTGAGCGCGACCATCATGTCCATGCTCGTGGTCTTTCTCTTGC
TGTGGGGTGTCACCTGGGGCCCAGTGACAGAAGCAGCCATATTTTATGAGACGCAGCCCAGCCTGTGGGCAGAGTCCGAATCACTGCTGA
AACCCTTGGCCAATGTGACGCTGACGTGCCAGGCCCACCTGGAGACTCCAGACTTCCAGCTGTTCAAGAATGGGGTGGCCCAGGAGCCTG
TGCACCTTGACTCACCTGCCATCAAGCACCAGTTCCTGCTGACGGGTGACACCCAGGGCCGCTACCGCTGCCGCTCGGGCTTGTCCACAG
GATGGACCCAGCTGAGCAAGCTCCTGGAGCTGACAGGGCCAAAGTCCTTGCCTGCTCCCTGGCTCTCGATGGCGCCAGTGTCCTGGATCA
CCCCCGGCCTGAAAACAACAGCAGTGTGCCGAGGTGTGCTGCGGGGTGTGACTTTTCTGCTGAGGCGGGAGGGCGACCATGAGTTTCTGG
AGGTGCCTGAGGCCCAGGAGGATGTGGAGGCCACCTTTCCAGTCCATCAGCCTGGCAACTACAGCTGCAGCTACCGGACCGATGGGGAAG
GCGCCCTCTCTGAGCCCAGCGCTACTGTGACCATTGAGGAGCTCGCTGCACCACCACCGCCTGTGCTGATGCACCATGGAGAGTCCTCCC
AGGTCCTGCACCCTGGCAACAAGGTGACCCTCACCTGCGTGGCTCCCCTGAGTGGAGTGGACTTCCAGCTACGGCGCGGGGAGAAAGAGC
TGCTGGTACCCAGGAGCAGCACCAGCCCAGATCGCATCTTCTTTCACCTGAACGCGGTGGCCCTGGGGGATGGAGGTCACTACACCTGCC
GCTACCGGCTGCATGACAACCAAAACGGCTGGTCCGGGGACAGCGCGCCGGTCGAGCTGATTCTGAGCGATGAAACAACCATGACAACCC
AAACCCCAGCCCCCATACAGGCTCCCTCTGCCATCCTGCCACTGCCTGGGCAGAGTGTGGAGCGGCTCTGTGTGGACCCCAGACACCGCC
AGGGGCCAGTGAACCTGCTCTCAGACCCTGAGCAAGGGGTTGAGGTGACTGGCCAGTATGAGAGGGAGAAGGCTGGGTTCTCATGGATCG
AAGTGACCTTCAAGAACCCCCTGGTATGGGTTCACGCATCCCCTGAACACGTGGTGGTGACTCGGAACCGAAGAAGCTCTGCGTACAAGT
GGAAGGAGACGCTATTCTCAGTGATGCCCGGCCTGAAGATGACCATGGACAAGACGGGTCTCCTGCTGCTCAGTGACCCAGACAAAGTGA
CCATCGGCCTGTTGTTCTGGGATGGCCGTGGGGAGGGGCTCCGGCTCCTTCTGCGTGACACTGACCGCTTCTCCAGCCACGTTGGAGGGA
CCCTTGGCCAGTTTTACCAGGAGGTGCTCTGGGGATCTCCAGCAGCATCAGATGACGGCAGACGCACGCTGAGGGTTCAGGGCAATGACC
ACTCTGCCACCAGAGAGCGCAGGCTGGATTACCAGGAGGGGCCCCCGGGAGTGGAGATTTCCTGCTGGTCTGTGGAGCTGTAGTTCTGAT
GGAAGGAGCTGTGCCCACCCTGTACACTTGGCTTCCCCCTGCAACTGCAGGGCCGCTTCTGGGGCCTGGACCACCATGGGGAGGAAGAGT

>4_4_3_A1BG-ITIH4_A1BG_chr19_58862757_ENST00000263100_ITIH4_chr3_52852299_ENST00000406595_length(amino acids)=534AA_BP=316
MLQTLTPDTHCTGVSATIMSMLVVFLLLWGVTWGPVTEAAIFYETQPSLWAESESLLKPLANVTLTCQAHLETPDFQLFKNGVAQEPVHL
DSPAIKHQFLLTGDTQGRYRCRSGLSTGWTQLSKLLELTGPKSLPAPWLSMAPVSWITPGLKTTAVCRGVLRGVTFLLRREGDHEFLEVP
EAQEDVEATFPVHQPGNYSCSYRTDGEGALSEPSATVTIEELAAPPPPVLMHHGESSQVLHPGNKVTLTCVAPLSGVDFQLRRGEKELLV
PRSSTSPDRIFFHLNAVALGDGGHYTCRYRLHDNQNGWSGDSAPVELILSDETTMTTQTPAPIQAPSAILPLPGQSVERLCVDPRHRQGP
VNLLSDPEQGVEVTGQYEREKAGFSWIEVTFKNPLVWVHASPEHVVVTRNRRSSAYKWKETLFSVMPGLKMTMDKTGLLLLSDPDKVTIG

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>4_4_4_A1BG-ITIH4_A1BG_chr19_58862757_ENST00000263100_ITIH4_chr3_52852299_ENST00000485816_length(transcript)=1764nt_BP=972nt
GGGCCTCATTGCTGCAGACGCTCACCCCAGACACTCACTGCACCGGAGTGAGCGCGACCATCATGTCCATGCTCGTGGTCTTTCTCTTGC
TGTGGGGTGTCACCTGGGGCCCAGTGACAGAAGCAGCCATATTTTATGAGACGCAGCCCAGCCTGTGGGCAGAGTCCGAATCACTGCTGA
AACCCTTGGCCAATGTGACGCTGACGTGCCAGGCCCACCTGGAGACTCCAGACTTCCAGCTGTTCAAGAATGGGGTGGCCCAGGAGCCTG
TGCACCTTGACTCACCTGCCATCAAGCACCAGTTCCTGCTGACGGGTGACACCCAGGGCCGCTACCGCTGCCGCTCGGGCTTGTCCACAG
GATGGACCCAGCTGAGCAAGCTCCTGGAGCTGACAGGGCCAAAGTCCTTGCCTGCTCCCTGGCTCTCGATGGCGCCAGTGTCCTGGATCA
CCCCCGGCCTGAAAACAACAGCAGTGTGCCGAGGTGTGCTGCGGGGTGTGACTTTTCTGCTGAGGCGGGAGGGCGACCATGAGTTTCTGG
AGGTGCCTGAGGCCCAGGAGGATGTGGAGGCCACCTTTCCAGTCCATCAGCCTGGCAACTACAGCTGCAGCTACCGGACCGATGGGGAAG
GCGCCCTCTCTGAGCCCAGCGCTACTGTGACCATTGAGGAGCTCGCTGCACCACCACCGCCTGTGCTGATGCACCATGGAGAGTCCTCCC
AGGTCCTGCACCCTGGCAACAAGGTGACCCTCACCTGCGTGGCTCCCCTGAGTGGAGTGGACTTCCAGCTACGGCGCGGGGAGAAAGAGC
TGCTGGTACCCAGGAGCAGCACCAGCCCAGATCGCATCTTCTTTCACCTGAACGCGGTGGCCCTGGGGGATGGAGGTCACTACACCTGCC
GCTACCGGCTGCATGACAACCAAAACGGCTGGTCCGGGGACAGCGCGCCGGTCGAGCTGATTCTGAGCGATGAAACAACCATGACAACCC
AAACCCCAGCCCCCATACAGGCTCCCTCTGCCATCCTGCCACTGCCTGGGCAGAGTGTGGAGCGGCTCTGTGTGGACCCCAGACACCGCC
AGGGGCCAGTGAACCTGCTCTCAGACCCTGAGCAAGGGGTTGAGGTGACTGGCCAGTATGAGAGGGAGAAGGCTGGGTTCTCATGGATCG
AAGTGACCTTCAAGAACCCCCTGGTATGGGTTCACGCATCCCCTGAACACGTGGTGGTGACTCGGAACCGAAGAAGCTCTGCGTACAAGT
GGAAGGAGACGCTATTCTCAGTGATGCCCGGCCTGAAGATGACCATGGACAAGACGGGTCTCCTGCTGCTCAGTGACCCAGACAAAGTGA
CCATCGGCCTGTTGTTCTGGGATGGCCGTGGGGAGGGGCTCCGGCTCCTTCTGCGTGACACTGACCGCTTCTCCAGCCACGTTGGAGGGA
CCCTTGGCCAGTTTTACCAGGAGGTGCTCTGGGGATCTCCAGCAGCATCAGATGACGGCAGACGCACGCTGAGGGTTCAGGGCAATGACC
ACTCTGCCACCAGAGAGCGCAGGCTGGATTACCAGGAGGGGCCCCCGGGAGTGGAGATTTCCTGCTGGTCTGTGGAGCTGTAGTTCTGAT
GGAAGGAGCTGTGCCCACCCTGTACACTTGGCTTCCCCCTGCAACTGCAGGGCCGCTTCTGGGGCCTGGACCACCATGGGGAGGAAGAGT

>4_4_4_A1BG-ITIH4_A1BG_chr19_58862757_ENST00000263100_ITIH4_chr3_52852299_ENST00000485816_length(amino acids)=534AA_BP=316
MLQTLTPDTHCTGVSATIMSMLVVFLLLWGVTWGPVTEAAIFYETQPSLWAESESLLKPLANVTLTCQAHLETPDFQLFKNGVAQEPVHL
DSPAIKHQFLLTGDTQGRYRCRSGLSTGWTQLSKLLELTGPKSLPAPWLSMAPVSWITPGLKTTAVCRGVLRGVTFLLRREGDHEFLEVP
EAQEDVEATFPVHQPGNYSCSYRTDGEGALSEPSATVTIEELAAPPPPVLMHHGESSQVLHPGNKVTLTCVAPLSGVDFQLRRGEKELLV
PRSSTSPDRIFFHLNAVALGDGGHYTCRYRLHDNQNGWSGDSAPVELILSDETTMTTQTPAPIQAPSAILPLPGQSVERLCVDPRHRQGP
VNLLSDPEQGVEVTGQYEREKAGFSWIEVTFKNPLVWVHASPEHVVVTRNRRSSAYKWKETLFSVMPGLKMTMDKTGLLLLSDPDKVTIG

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Fusion Gene PPI Analysis for A1BG-ITIH4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for A1BG-ITIH4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneA1BGP04217DB01593ZincSmall moleculeApproved|Investigational
HgeneA1BGP04217DB09130CopperSmall moleculeApproved|Investigational
HgeneA1BGP04217DB14487Zinc acetateSmall moleculeApproved|Investigational

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Related Diseases for A1BG-ITIH4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneA1BGC0019209Hepatomegaly1CTD_human
HgeneA1BGC0036341Schizophrenia1CTD_human
TgeneC0005586Bipolar Disorder3PSYGENET
TgeneC0007102Malignant tumor of colon1CTD_human
TgeneC0009375Colonic Neoplasms1CTD_human
TgeneC0032580Adenomatous Polyposis Coli1CTD_human
TgeneC2713442Polyposis, Adenomatous Intestinal1CTD_human
TgeneC2713443Familial Intestinal Polyposis1CTD_human