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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APOBEC3A-GSTP1 (FusionGDB2 ID:HG200315TG2950)

Fusion Gene Summary for APOBEC3A-GSTP1

check button Fusion gene summary
Fusion gene informationFusion gene name: APOBEC3A-GSTP1
Fusion gene ID: hg200315tg2950
HgeneTgene
Gene symbol

APOBEC3A

GSTP1

Gene ID

200315

2950

Gene nameapolipoprotein B mRNA editing enzyme catalytic subunit 3Aglutathione S-transferase pi 1
SynonymsA3A|ARP3|PHRBN|bK150C2.1DFN7|FAEES3|GST3|GSTP|HEL-S-22|PI
Cytomap('APOBEC3A')('GSTP1')

22q13.1

11q13.2

Type of geneprotein-codingprotein-coding
DescriptionDNA dC->dU-editing enzyme APOBEC-3Aapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3Aphorbolin-1probable DNA dC->dU-editing enzyme APOBEC-3Aglutathione S-transferase PGST class-piGSTP1-1deafness, X-linked 7epididymis secretory protein Li 22fatty acid ethyl ester synthase III
Modification date2020032920200329
UniProtAcc

P31941

.
Ensembl transtripts involved in fusion geneENST00000249116, ENST00000402255, 
ENST00000495988, 
Fusion gene scores* DoF score9 X 6 X 1=545 X 4 X 5=100
# samples 95
** MAII scorelog2(9/54*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APOBEC3A [Title/Abstract] AND GSTP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPOBEC3A(39371673)-GSTP1(67354124), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPOBEC3A

GO:0010529

negative regulation of transposition

16527742|20062055|21123384

HgeneAPOBEC3A

GO:0044355

clearance of foreign intracellular DNA

20062055

HgeneAPOBEC3A

GO:0045071

negative regulation of viral genome replication

16527742

HgeneAPOBEC3A

GO:0045087

innate immune response

21123384

HgeneAPOBEC3A

GO:0051607

defense response to virus

21123384|22457529

HgeneAPOBEC3A

GO:0070383

DNA cytosine deamination

16527742|21123384

HgeneAPOBEC3A

GO:0071466

cellular response to xenobiotic stimulus

20062055

HgeneAPOBEC3A

GO:0080111

DNA demethylation

21496894

TgeneGSTP1

GO:0006469

negative regulation of protein kinase activity

16636664

TgeneGSTP1

GO:0006749

glutathione metabolic process

1540159

TgeneGSTP1

GO:0006805

xenobiotic metabolic process

1540159

TgeneGSTP1

GO:0009890

negative regulation of biosynthetic process

18962899

TgeneGSTP1

GO:0032691

negative regulation of interleukin-1 beta production

18962899

TgeneGSTP1

GO:0032720

negative regulation of tumor necrosis factor production

18962899

TgeneGSTP1

GO:0043407

negative regulation of MAP kinase activity

11408560

TgeneGSTP1

GO:0043508

negative regulation of JUN kinase activity

16636664

TgeneGSTP1

GO:0043651

linoleic acid metabolic process

16624487

TgeneGSTP1

GO:0051771

negative regulation of nitric-oxide synthase biosynthetic process

18962899

TgeneGSTP1

GO:0070373

negative regulation of ERK1 and ERK2 cascade

11408560

TgeneGSTP1

GO:0071638

negative regulation of monocyte chemotactic protein-1 production

18962899

TgeneGSTP1

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

16636664



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for APOBEC3A-GSTP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for APOBEC3A-GSTP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for APOBEC3A-GSTP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:39371673/:67354124)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APOBEC3A

P31941

.
FUNCTION: DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. {ECO:0000269|PubMed:10469298, ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:19461882, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:20615867, ECO:0000269|PubMed:21123384, ECO:0000269|PubMed:21368204, ECO:0000269|PubMed:21460793, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:22457529, ECO:0000269|PubMed:22896697}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for APOBEC3A-GSTP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for APOBEC3A-GSTP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for APOBEC3A-GSTP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for APOBEC3A-GSTP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPOBEC3AC0006142Malignant neoplasm of breast1CTD_human
HgeneAPOBEC3AC0006826Malignant Neoplasms1CTD_human
HgeneAPOBEC3AC0027651Neoplasms1CTD_human
HgeneAPOBEC3AC0033975Psychotic Disorders1PSYGENET
HgeneAPOBEC3AC0086692Benign Neoplasm1CTD_human
HgeneAPOBEC3AC0087031Juvenile-Onset Still Disease1CTD_human
HgeneAPOBEC3AC0349204Nonorganic psychosis1PSYGENET
HgeneAPOBEC3AC0678222Breast Carcinoma1CTD_human
HgeneAPOBEC3AC1257931Mammary Neoplasms, Human1CTD_human
HgeneAPOBEC3AC1458155Mammary Neoplasms1CTD_human
HgeneAPOBEC3AC3495559Juvenile arthritis1CTD_human
HgeneAPOBEC3AC3714758Juvenile psoriatic arthritis1CTD_human
HgeneAPOBEC3AC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneAPOBEC3AC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
HgeneAPOBEC3AC4704874Mammary Carcinoma, Human1CTD_human
TgeneC0032927Precancerous Conditions6CTD_human
TgeneC0282313Condition, Preneoplastic6CTD_human
TgeneC0033578Prostatic Neoplasms5CTD_human
TgeneC0376358Malignant neoplasm of prostate5CTD_human
TgeneC0004096Asthma4CTD_human
TgeneC0019207Hepatoma, Morris4CTD_human
TgeneC0019208Hepatoma, Novikoff4CTD_human
TgeneC0023904Liver Neoplasms, Experimental4CTD_human
TgeneC0086404Experimental Hepatoma4CTD_human
TgeneC0005684Malignant neoplasm of urinary bladder3CTD_human
TgeneC0005695Bladder Neoplasm3CTD_human
TgeneC0019193Hepatitis, Toxic2CTD_human
TgeneC0024623Malignant neoplasm of stomach2CTD_human
TgeneC0030567Parkinson Disease2CTD_human
TgeneC0036341Schizophrenia2PSYGENET
TgeneC0038356Stomach Neoplasms2CTD_human
TgeneC0860207Drug-Induced Liver Disease2CTD_human
TgeneC1262760Hepatitis, Drug-Induced2CTD_human
TgeneC1708349Hereditary Diffuse Gastric Cancer2CTD_human
TgeneC3658290Drug-Induced Acute Liver Injury2CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury2CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity2CTD_human
TgeneC0002736Amyotrophic Lateral Sclerosis1CTD_human
TgeneC0004352Autistic Disorder1CTD_human
TgeneC0004403Autosome Abnormalities1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0007097Carcinoma1CTD_human
TgeneC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneC0007134Renal Cell Carcinoma1CTD_human
TgeneC0007273Carotid Artery Diseases1CTD_human
TgeneC0008625Chromosome Aberrations1CTD_human
TgeneC0011616Contact Dermatitis1CTD_human
TgeneC0013182Drug Allergy1CTD_human
TgeneC0017638Glioma1CTD_human
TgeneC0019829Hodgkin Disease1CTD_human
TgeneC0020538Hypertensive disease1CTD_human
TgeneC0022650Kidney Calculi1CTD_human
TgeneC0022658Kidney Diseases1CTD_human
TgeneC0022660Kidney Failure, Acute1CTD_human
TgeneC0023473Myeloid Leukemia, Chronic1CTD_human
TgeneC0024121Lung Neoplasms1CTD_human
TgeneC0027540Necrosis1CTD_human
TgeneC0029463Osteosarcoma1CTD_human
TgeneC0032230Pleural Rub1CTD_human
TgeneC0033937Psychoses, Drug1CTD_human
TgeneC0033941Psychoses, Substance-Induced1CTD_human
TgeneC0033975Psychotic Disorders1PSYGENET
TgeneC0034642Rales1CTD_human
TgeneC0035234Respiratory Sounds1CTD_human
TgeneC0035508Rhonchi1CTD_human
TgeneC0036939Shared Paranoid Disorder1PSYGENET
TgeneC0038450Stridor1CTD_human
TgeneC0042594Vestibular Diseases1CTD_human
TgeneC0043144Wheezing1CTD_human
TgeneC0151744Myocardial Ischemia1CTD_human
TgeneC0152266Mixed Cellularity Hodgkin Lymphoma1CTD_human
TgeneC0152267Hodgkin lymphoma, lymphocyte depletion1CTD_human
TgeneC0162351Contact hypersensitivity1CTD_human
TgeneC0205696Anaplastic carcinoma1CTD_human
TgeneC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneC0205698Undifferentiated carcinoma1CTD_human
TgeneC0205699Carcinomatosis1CTD_human
TgeneC0205944Sarcoma, Epithelioid1CTD_human
TgeneC0205945Sarcoma, Spindle Cell1CTD_human
TgeneC0220597Adult Hodgkin Lymphoma1CTD_human
TgeneC0235874Disease Exacerbation1CTD_human
TgeneC0236733Amphetamine-Related Disorders1CTD_human
TgeneC0236804Amphetamine Addiction1CTD_human
TgeneC0236807Amphetamine Abuse1CTD_human
TgeneC0242379Malignant neoplasm of lung1CTD_human
TgeneC0259783mixed gliomas1CTD_human
TgeneC0270736Essential Tremor1CTD_human
TgeneC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneC0282612Prostatic Intraepithelial Neoplasias1CTD_human
TgeneC0349204Nonorganic psychosis1PSYGENET
TgeneC0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
TgeneC0393615Familial Tremor1CTD_human
TgeneC0400966Non-alcoholic Fatty Liver Disease1CTD_human
TgeneC0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
TgeneC0555198Malignant Glioma1CTD_human
TgeneC0577631Carotid Atherosclerosis1CTD_human
TgeneC0600178External Carotid Artery Diseases1CTD_human
TgeneC0600427Cocaine Dependence1PSYGENET
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0750986Internal Carotid Artery Diseases1CTD_human
TgeneC0750987Arterial Diseases, Common Carotid1CTD_human
TgeneC0948089Acute Coronary Syndrome1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1261473Sarcoma1CTD_human
TgeneC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneC1266194Lymphocyte Rich Classical Hodgkin Lymphoma1CTD_human
TgeneC1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneC1334968Nodular Lymphocyte Predominant Hodgkin Lymphoma1CTD_human
TgeneC1456865Ureteral Calculi1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1565662Acute Kidney Insufficiency1CTD_human
TgeneC2239176Liver carcinoma1CTD_human
TgeneC2609414Acute kidney injury1CTD_human
TgeneC3241937Nonalcoholic Steatohepatitis1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human
TgeneC4721453Peripheral Nervous System Diseases1CTD_human