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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:APOBEC3F-HGSNAT (FusionGDB2 ID:HG200316TG138050) |
Fusion Gene Summary for APOBEC3F-HGSNAT |
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Fusion gene information | Fusion gene name: APOBEC3F-HGSNAT | Fusion gene ID: hg200316tg138050 | Hgene | Tgene | Gene symbol | APOBEC3F | HGSNAT | Gene ID | 200316 | 138050 |
Gene name | apolipoprotein B mRNA editing enzyme catalytic subunit 3F | heparan-alpha-glucosaminide N-acetyltransferase | |
Synonyms | A3F|ARP8|BK150C2.4.MRNA|KA6 | HGNAT|MPS3C|RP73|TMEM76 | |
Cytomap | ('APOBEC3F')('HGSNAT') 22q13.1 | 8p11.21-p11.1 | |
Type of gene | protein-coding | protein-coding | |
Description | DNA dC->dU-editing enzyme APOBEC-3Fapolipoprotein B editing enzyme catalytic polypeptide-like 3Fapolipoprotein B mRNA editing enzyme cytidine deaminaseapolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3Finduced upon T-cell activation | heparan-alpha-glucosaminide N-acetyltransferasetransmembrane protein 76 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q8IUX4 | . | |
Ensembl transtripts involved in fusion gene | ENST00000308521, ENST00000381565, ENST00000491387, | ||
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 12 X 13 X 4=624 |
# samples | 3 | 13 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(13/624*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: APOBEC3F [Title/Abstract] AND HGSNAT [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | APOBEC3F(39416213)-HGSNAT(43057460), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | APOBEC3F | GO:0002230 | positive regulation of defense response to virus by host | 17121840 |
Hgene | APOBEC3F | GO:0010529 | negative regulation of transposition | 16527742|20062055 |
Hgene | APOBEC3F | GO:0016553 | base conversion or substitution editing | 17121840 |
Hgene | APOBEC3F | GO:0045071 | negative regulation of viral genome replication | 16378963|17121840 |
Hgene | APOBEC3F | GO:0045087 | innate immune response | 17121840 |
Hgene | APOBEC3F | GO:0045869 | negative regulation of single stranded viral RNA replication via double stranded DNA intermediate | 17121840|21835787 |
Hgene | APOBEC3F | GO:0048525 | negative regulation of viral process | 17121840 |
Hgene | APOBEC3F | GO:0051607 | defense response to virus | 21835787|22915799 |
Hgene | APOBEC3F | GO:0070383 | DNA cytosine deamination | 21835787 |
Hgene | APOBEC3F | GO:0080111 | DNA demethylation | 21496894 |
Tgene | HGSNAT | GO:0007041 | lysosomal transport | 20650889 |
Tgene | HGSNAT | GO:0051259 | protein complex oligomerization | 20650889 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for APOBEC3F-HGSNAT |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for APOBEC3F-HGSNAT |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for APOBEC3F-HGSNAT |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:39416213/:43057460) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
APOBEC3F | . |
FUNCTION: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against Vif-deficient HIV-1 (PubMed:15152192, PubMed:23001005). After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. {ECO:0000269|PubMed:15152192, ECO:0000269|PubMed:16378963, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:19458006, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:20219927, ECO:0000269|PubMed:20335265, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22807680, ECO:0000269|PubMed:22915799, ECO:0000269|PubMed:23001005, ECO:0000269|PubMed:23097438, ECO:0000269|PubMed:23152537}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for APOBEC3F-HGSNAT |
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Fusion Gene PPI Analysis for APOBEC3F-HGSNAT |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for APOBEC3F-HGSNAT |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for APOBEC3F-HGSNAT |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0086649 | MPS III C | 11 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C4225287 | RETINITIS PIGMENTOSA 73 | 3 | CTD_human;GENOMICS_ENGLAND;UNIPROT | |
Tgene | C0026706 | Mucopolysaccharidosis III | 2 | CTD_human;GENOMICS_ENGLAND | |
Tgene | C0035334 | Retinitis Pigmentosa | 1 | ORPHANET |