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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:ARL13B-EPS8 (FusionGDB2 ID:HG200894TG2059)

Fusion Gene Summary for ARL13B-EPS8

check button Fusion gene summary
Fusion gene informationFusion gene name: ARL13B-EPS8
Fusion gene ID: hg200894tg2059
HgeneTgene
Gene symbol

ARL13B

EPS8

Gene ID

200894

2059

Gene nameADP ribosylation factor like GTPase 13Bepidermal growth factor receptor pathway substrate 8
SynonymsARL2L1|JBTS8DFNB102
Cytomap('ARL13B')('EPS8')

3q11.1-q11.2

12p12.3

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor-like protein 13BADP-ribosylation factor-like 13BADP-ribosylation factor-like 2-like 1ARL2-like protein 1epidermal growth factor receptor kinase substrate 8
Modification date2020031320200327
UniProtAcc.

Q12929

Ensembl transtripts involved in fusion geneENST00000486562, ENST00000394222, 
ENST00000471138, ENST00000539730, 
ENST00000303097, ENST00000535334, 
Fusion gene scores* DoF score5 X 3 X 5=759 X 7 X 4=252
# samples 59
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARL13B [Title/Abstract] AND EPS8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARL13B(93714788)-EPS8(15823857), # samples:1
Anticipated loss of major functional domain due to fusion event.ARL13B-EPS8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARL13B-EPS8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARL13B-EPS8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARL13B-EPS8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARL13B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across EPS8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8365-01AARL13Bchr3

93714788

+EPS8chr12

15823857

-


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Fusion Gene ORF analysis for ARL13B-EPS8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000486562ENST00000281172ARL13Bchr3

93714788

+EPS8chr12

15823857

-
3UTR-3CDSENST00000486562ENST00000543523ARL13Bchr3

93714788

+EPS8chr12

15823857

-
3UTR-3CDSENST00000486562ENST00000543612ARL13Bchr3

93714788

+EPS8chr12

15823857

-
3UTR-intronENST00000486562ENST00000540613ARL13Bchr3

93714788

+EPS8chr12

15823857

-
3UTR-intronENST00000486562ENST00000542903ARL13Bchr3

93714788

+EPS8chr12

15823857

-
5CDS-intronENST00000394222ENST00000540613ARL13Bchr3

93714788

+EPS8chr12

15823857

-
5CDS-intronENST00000394222ENST00000542903ARL13Bchr3

93714788

+EPS8chr12

15823857

-
5CDS-intronENST00000471138ENST00000540613ARL13Bchr3

93714788

+EPS8chr12

15823857

-
5CDS-intronENST00000471138ENST00000542903ARL13Bchr3

93714788

+EPS8chr12

15823857

-
5UTR-3CDSENST00000539730ENST00000281172ARL13Bchr3

93714788

+EPS8chr12

15823857

-
5UTR-3CDSENST00000539730ENST00000543523ARL13Bchr3

93714788

+EPS8chr12

15823857

-
5UTR-3CDSENST00000539730ENST00000543612ARL13Bchr3

93714788

+EPS8chr12

15823857

-
5UTR-intronENST00000539730ENST00000540613ARL13Bchr3

93714788

+EPS8chr12

15823857

-
5UTR-intronENST00000539730ENST00000542903ARL13Bchr3

93714788

+EPS8chr12

15823857

-
In-frameENST00000394222ENST00000281172ARL13Bchr3

93714788

+EPS8chr12

15823857

-
In-frameENST00000394222ENST00000543523ARL13Bchr3

93714788

+EPS8chr12

15823857

-
In-frameENST00000394222ENST00000543612ARL13Bchr3

93714788

+EPS8chr12

15823857

-
In-frameENST00000471138ENST00000281172ARL13Bchr3

93714788

+EPS8chr12

15823857

-
In-frameENST00000471138ENST00000543523ARL13Bchr3

93714788

+EPS8chr12

15823857

-
In-frameENST00000471138ENST00000543612ARL13Bchr3

93714788

+EPS8chr12

15823857

-
intron-3CDSENST00000303097ENST00000281172ARL13Bchr3

93714788

+EPS8chr12

15823857

-
intron-3CDSENST00000303097ENST00000543523ARL13Bchr3

93714788

+EPS8chr12

15823857

-
intron-3CDSENST00000303097ENST00000543612ARL13Bchr3

93714788

+EPS8chr12

15823857

-
intron-3CDSENST00000535334ENST00000281172ARL13Bchr3

93714788

+EPS8chr12

15823857

-
intron-3CDSENST00000535334ENST00000543523ARL13Bchr3

93714788

+EPS8chr12

15823857

-
intron-3CDSENST00000535334ENST00000543612ARL13Bchr3

93714788

+EPS8chr12

15823857

-
intron-intronENST00000303097ENST00000540613ARL13Bchr3

93714788

+EPS8chr12

15823857

-
intron-intronENST00000303097ENST00000542903ARL13Bchr3

93714788

+EPS8chr12

15823857

-
intron-intronENST00000535334ENST00000540613ARL13Bchr3

93714788

+EPS8chr12

15823857

-
intron-intronENST00000535334ENST00000542903ARL13Bchr3

93714788

+EPS8chr12

15823857

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394222ARL13Bchr393714788+ENST00000543523EPS8chr1215823857-38974052752737820
ENST00000394222ARL13Bchr393714788+ENST00000281172EPS8chr1215823857-38934052752737820
ENST00000394222ARL13Bchr393714788+ENST00000543612EPS8chr1215823857-30724052752737820
ENST00000471138ARL13Bchr393714788+ENST00000543523EPS8chr1215823857-38913992692731820
ENST00000471138ARL13Bchr393714788+ENST00000281172EPS8chr1215823857-38873992692731820
ENST00000471138ARL13Bchr393714788+ENST00000543612EPS8chr1215823857-30663992692731820

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394222ENST00000543523ARL13Bchr393714788+EPS8chr1215823857-0.0005556040.9994444
ENST00000394222ENST00000281172ARL13Bchr393714788+EPS8chr1215823857-0.0005698320.9994301
ENST00000394222ENST00000543612ARL13Bchr393714788+EPS8chr1215823857-0.0013334830.9986665
ENST00000471138ENST00000543523ARL13Bchr393714788+EPS8chr1215823857-0.0005618090.9994382
ENST00000471138ENST00000281172ARL13Bchr393714788+EPS8chr1215823857-0.0005758520.9994242
ENST00000471138ENST00000543612ARL13Bchr393714788+EPS8chr1215823857-0.0013524330.99864763

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Fusion Genomic Features for ARL13B-EPS8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ARL13B-EPS8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:93714788/chr12:15823857)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EPS8

Q12929

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARL13Bchr3:93714788chr12:15823857ENST00000394222+21028_3543429.0Nucleotide bindingGTP
HgeneARL13Bchr3:93714788chr12:15823857ENST00000471138+21128_3543524.0Nucleotide bindingGTP
TgeneEPS8chr3:93714788chr12:15823857ENST00000281172221421_44045823.0Compositional biasNote=Pro-rich
TgeneEPS8chr3:93714788chr12:15823857ENST00000281172221615_65145823.0Compositional biasNote=Pro-rich
TgeneEPS8chr3:93714788chr12:15823857ENST00000281172221659_66445823.0Compositional biasNote=Poly-Ser
TgeneEPS8chr3:93714788chr12:15823857ENST00000543523322421_44045823.0Compositional biasNote=Pro-rich
TgeneEPS8chr3:93714788chr12:15823857ENST00000543523322615_65145823.0Compositional biasNote=Pro-rich
TgeneEPS8chr3:93714788chr12:15823857ENST00000543523322659_66445823.0Compositional biasNote=Poly-Ser
TgeneEPS8chr3:93714788chr12:15823857ENST00000543612221421_44045823.0Compositional biasNote=Pro-rich
TgeneEPS8chr3:93714788chr12:15823857ENST00000543612221615_65145823.0Compositional biasNote=Pro-rich
TgeneEPS8chr3:93714788chr12:15823857ENST00000543612221659_66445823.0Compositional biasNote=Poly-Ser
TgeneEPS8chr3:93714788chr12:15823857ENST00000281172221381_41445823.0DomainNote=PH%3B second part
TgeneEPS8chr3:93714788chr12:15823857ENST00000281172221531_59045823.0DomainSH3
TgeneEPS8chr3:93714788chr12:15823857ENST0000028117222169_12945823.0DomainNote=PH%3B first part
TgeneEPS8chr3:93714788chr12:15823857ENST00000543523322381_41445823.0DomainNote=PH%3B second part
TgeneEPS8chr3:93714788chr12:15823857ENST00000543523322531_59045823.0DomainSH3
TgeneEPS8chr3:93714788chr12:15823857ENST0000054352332269_12945823.0DomainNote=PH%3B first part
TgeneEPS8chr3:93714788chr12:15823857ENST00000543612221381_41445823.0DomainNote=PH%3B second part
TgeneEPS8chr3:93714788chr12:15823857ENST00000543612221531_59045823.0DomainSH3
TgeneEPS8chr3:93714788chr12:15823857ENST0000054361222169_12945823.0DomainNote=PH%3B first part
TgeneEPS8chr3:93714788chr12:15823857ENST00000281172221649_82245823.0RegionEffector region
TgeneEPS8chr3:93714788chr12:15823857ENST00000281172221680_69845823.0RegionAmphipathic helix
TgeneEPS8chr3:93714788chr12:15823857ENST00000281172221718_73845823.0RegionHelix bundle 1
TgeneEPS8chr3:93714788chr12:15823857ENST00000281172221762_76745823.0RegionHelix bundle 3
TgeneEPS8chr3:93714788chr12:15823857ENST00000281172221766_78545823.0RegionHelix bundle 4
TgeneEPS8chr3:93714788chr12:15823857ENST00000543523322649_82245823.0RegionEffector region
TgeneEPS8chr3:93714788chr12:15823857ENST00000543523322680_69845823.0RegionAmphipathic helix
TgeneEPS8chr3:93714788chr12:15823857ENST00000543523322718_73845823.0RegionHelix bundle 1
TgeneEPS8chr3:93714788chr12:15823857ENST00000543523322762_76745823.0RegionHelix bundle 3
TgeneEPS8chr3:93714788chr12:15823857ENST00000543523322766_78545823.0RegionHelix bundle 4
TgeneEPS8chr3:93714788chr12:15823857ENST00000543612221649_82245823.0RegionEffector region
TgeneEPS8chr3:93714788chr12:15823857ENST00000543612221680_69845823.0RegionAmphipathic helix
TgeneEPS8chr3:93714788chr12:15823857ENST00000543612221718_73845823.0RegionHelix bundle 1
TgeneEPS8chr3:93714788chr12:15823857ENST00000543612221762_76745823.0RegionHelix bundle 3
TgeneEPS8chr3:93714788chr12:15823857ENST00000543612221766_78545823.0RegionHelix bundle 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARL13Bchr3:93714788chr12:15823857ENST00000303097+18192_2450322.0Coiled coilOntology_term=ECO:0000255
HgeneARL13Bchr3:93714788chr12:15823857ENST00000394222+210192_24543429.0Coiled coilOntology_term=ECO:0000255
HgeneARL13Bchr3:93714788chr12:15823857ENST00000471138+211192_24543524.0Coiled coilOntology_term=ECO:0000255
HgeneARL13Bchr3:93714788chr12:15823857ENST00000535334+19192_2450326.0Coiled coilOntology_term=ECO:0000255
HgeneARL13Bchr3:93714788chr12:15823857ENST00000303097+18369_4190322.0Compositional biasNote=Pro-rich
HgeneARL13Bchr3:93714788chr12:15823857ENST00000394222+210369_41943429.0Compositional biasNote=Pro-rich
HgeneARL13Bchr3:93714788chr12:15823857ENST00000471138+211369_41943524.0Compositional biasNote=Pro-rich
HgeneARL13Bchr3:93714788chr12:15823857ENST00000535334+19369_4190326.0Compositional biasNote=Pro-rich
HgeneARL13Bchr3:93714788chr12:15823857ENST00000303097+18130_1330322.0Nucleotide bindingGTP
HgeneARL13Bchr3:93714788chr12:15823857ENST00000303097+1828_350322.0Nucleotide bindingGTP
HgeneARL13Bchr3:93714788chr12:15823857ENST00000303097+1871_750322.0Nucleotide bindingGTP
HgeneARL13Bchr3:93714788chr12:15823857ENST00000394222+210130_13343429.0Nucleotide bindingGTP
HgeneARL13Bchr3:93714788chr12:15823857ENST00000394222+21071_7543429.0Nucleotide bindingGTP
HgeneARL13Bchr3:93714788chr12:15823857ENST00000471138+211130_13343524.0Nucleotide bindingGTP
HgeneARL13Bchr3:93714788chr12:15823857ENST00000471138+21171_7543524.0Nucleotide bindingGTP
HgeneARL13Bchr3:93714788chr12:15823857ENST00000535334+19130_1330326.0Nucleotide bindingGTP
HgeneARL13Bchr3:93714788chr12:15823857ENST00000535334+1928_350326.0Nucleotide bindingGTP
HgeneARL13Bchr3:93714788chr12:15823857ENST00000535334+1971_750326.0Nucleotide bindingGTP


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Fusion Gene Sequence for ARL13B-EPS8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6549_6549_1_ARL13B-EPS8_ARL13B_chr3_93714788_ENST00000394222_EPS8_chr12_15823857_ENST00000281172_length(transcript)=3893nt_BP=405nt
CGCGGGGCTTTTCTTTAGCCGGGTCCCGCTAACTCGGCTACGGTGTATCTGCGTCTTTGGTCAGGTTGTTCCTTGGCTAAGAGGGCAGTC
GTCGCGGACCCACGCGGTTAGCAAGGCTTAGTGCTCGGGCCGGCCGCCTTCACTTCCCTCCCGGCTTTTCCTCCCGACTTATCCACTTTA
GGGGCGTCTCGGAGTGCCGGAGGCCCCCGGGGAAGAGCGGGGTGCCGGTGTCCGCTCCGGGCTCGGATGGGAAGTGGTGGGAGGAGCGAC
CCGGGATGTTCAGTCTGATGGCCAGTTGCTGCGGCTGGTTCAAGCGGTGGCGGGAGCCTGTCAGAAAGGTGACTCTTTTGATGGTGGGAC
TTGATAATGCTGGTAAAACCGCAACAGCAAAGGGAATCCAAGGAGAACAAAGGAAGAATTATGCACGGGACAGTGTCAGCAGTGTGTCAG
ATATATCTCAATACCGTGTTGAACACTTGACTACCTTTGTCCTGGATCGGAAAGATGCTATGATCACTGTTGATGATGGAATAAGGAAAT
TGAAATTGCTTGATGCCAAGGGCAAAGTGTGGACTCAAGATATGATTCTTCAAGTGGATGACAGAGCTGTGAGCCTGATTGATTTAGAAT
CAAAGAATGAACTGGAGAATTTTCCTTTAAACACAATCCAGCACTGCCAAGCTGTGATGCATTCATGCAGCTATGATTCAGTTCTTGCAC
TGGTGTGCAAAGAGCCAACCCAGAACAAGCCAGATCTTCATCTCTTCCAGTGTGATGAGGTTAAGGCAAACCTAATTAGTGAAGATATTG
AAAGTGCAATCAGTGACAGTAAAGGAGGGAAACAGAAGAGGCGGCCCGACGCCCTGAGGATGATTTCCAATGCAGACCCTAGTATACCGC
CTCCACCCAGAGCTCCTGCCCCTGCGCCCCCTGGGACCGTCACCCAGGTGGATGTTAGAAGTCGAGTGGCAGCCTGGTCTGCATGGGCAG
CCGACCAAGGGGACTTTGAGAAACCAAGGCAGTATCATGAGCAGGAAGAAACACCTGAGATGATGGCAGCCCGCATTGACAGAGATGTGC
AAATCTTAAACCACATTTTGGATGACATTGAATTTTTTATCACAAAACTCCAAAAAGCAGCAGAAGCATTTTCTGAGCTTTCTAAAAGGA
AGAAAAACAAGAAAGGTAAAAGGAAAGGACCAGGAGAGGGTGTTTTAACGCTGCGGGCAAAACCTCCACCTCCTGATGAATTTCTTGACT
GTTTCCAAAAGTTTAAACACGGATTTAACCTTCTGGCCAAACTGAAGTCTCATATTCAGAATCCTAGTGCTGCAGATTTGGTTCACTTTT
TGTTTACTCCATTAAATATGGTGGTGCAGGCAACAGGAGGTCCTGAACTAGCCAGTTCAGTACTTAGTCCCCTATTGAATAAGGACACAA
TTGATTTCTTAAATTATACTGTCAATGGTGATGAACGGCAGCTGTGGATGTCATTGGGAGGAACTTGGATGAAAGCCAGAGCAGAGTGGC
CAAAAGAACAGTTTATTCCACCATATGTTCCACGATTCCGCAATGGCTGGGAGCCCCCAATGCTGAACTTTATGGGAGCCACAATGGAAC
AAGATCTTTATCAACTGGCAGAATCTGTGGCAAATGTAGCAGAACATCAGCGCAAACAGGAAATAAAAAGATTATCCACAGAGCATTCCA
GTGTATCAGAGTATCATCCAGCCGATGGCTATGCGTTCAGTAGCAACATTTACACAAGAGGATCCCACCTGGACCAAGGGGAAGCTGCTG
TTGCTTTTAAGCCAACTTCTAATCGCCATATAGATAGAAATTATGAACCACTCAAAACACAACCCAAGAAATATGCCAAATCCAAGTATG
ACTTTGTAGCAAGGAACAACAGTGAGCTCTCGGTTCTAAAGGATGATATTTTAGAGATACTTGATGATCGGAAGCAATGGTGGAAAGTTC
GAAATGCAAGTGGAGACTCTGGATTTGTGCCAAATAACATTTTGGATATTGTGAGACCTCCAGAATCTGGATTGGGGCGTGCTGATCCAC
CTTATACTCATACTATACAGAAACAAAGGATGGAGTATGGCCCAAGACCAGCTGATACTCCCCCTGCTCCATCACCTCCTCCAACACCAG
CTCCTGTTCCTGTTCCCCTTCCCCCTTCCACTCCAGCACCTGTTCCTGTGTCAAAGGTCCCAGCAAATATAACACGTCAAAACAGCAGCT
CCAGTGACAGTGGTGGCAGTATCGTGCGAGACAGCCAGAGACACAAACAACTTCCGGTGGACCGAAGGAAATCTCAGATGGAGGAAGTGC
AAGATGAACTCATCCACAGACTGACCATTGGTCGGAGTGCCGCTCAGAAGAAATTCCATGTGCCACGGCAGAACGTGCCAGTTATCAATA
TCACTTACGACTCCACACCAGAGGATGTGAAGACGTGGTTACAGTCAAAGGGATTCAACCCTGTGACTGTCAATAGTCTTGGAGTATTAA
ATGGTGCACAACTTTTCTCTCTCAATAAGGATGAACTGAGGACAGTCTGCCCTGAAGGGGCGAGAGTCTATAGCCAAATCACTGTACAAA
AAGCTGCATTGGAGGATAGCAGTGGCAGCTCCGAGTTACAAGAAATTATGAGAAGACGACAGGAAAAAATCAGTGCTGCCGCTAGTGATT
CAGGAGTGGAATCTTTTGATGAAGGAAGCAGTCACTAATTTGTTTGTTTGTATTTAAACTCCATTGTTTTTGGCATTATTCCAACATGCT
TTGTTTTAAGAAGCCTTGAAGGGAATGTCAGATTCATTTTTCTTGATGTAATTTATCACCATAAAAAAAAACCCATGCAAACCTGAGTGA
GCACAGGATTTGCTTCTAGGCCCATTATTTTTATTAAAACTGAAAAAATTTAAACTGAATTTTTTGACCTTGGAAAATATTTTTCTTACT
TTACCAAGGTGAAGTTTCCTTAATTAGACTAATTATTTTATCCCCATCCCAGGGTATAAACAGGAATTGTTTTGATAGTGGTGGAGTTAT
TCACTGCAACAAAGCAACAATGTTGTCCATGATTCAAAATCTAAGCAGTTTCGATTTTGCCTGTGAATATGGTGTCTGTCATTCAGGGCA
TAGCTCACTGTAGGCTAGCCTCTGCTTACTTAAGTCTCTTCTCTGACATACTCAATGGAAGAATATTTAGATTTATTTAAAGTTCTTAAT
GCCAACAGTTTAAAAAAAAATTAAAACATTTGAATGAACTGTAAAGTACAGCCATACCTTGGACATGCAAATATAAATCTATGGAGCATT
CTCAAGAGAGTTTGTCATGGCTCTGTTGATTGCAACTCCTTGTATAGCTTGTATTTTGATTTAGTTTATATTCTGCTTATTATGTATACT
GTGTTCTTATATATGAGAAAGCACAAATGCGAAAGAGGTCATGTCTTCTCAAAATCTAGCAAAGGAAGTAGTCTGCATTGGTGTGCATTA
CAGTATTTTGCTTAATGAAAGCCTCAGTTCTGAATGTTGATATGAGTAGTTAAAAGGAAGTGGGGCCATTTTATGTGTTTATCTGTGTCA
AGTATTTCTGGTAATAAGAAGCACTTAATTTACACATATTTTAATCCTGTGAAAGATTCCACATAGAGAAAAGAAAGATACCTAACCTTC
AACAAATGTTATTTTTGGAAACACAATTTTTGTCATTAAATGTTATATTATTTCACATATATAAAACAGATGTTATGTAAGAATGTTGTA
TATTTTAACATAAATCATTTAGAGAAATTATCTAGATTCATTAATTTTCATAGTGCCTTTTTCACATGAGTCAGCTGGAAAGTCTGCAAT

>6549_6549_1_ARL13B-EPS8_ARL13B_chr3_93714788_ENST00000394222_EPS8_chr12_15823857_ENST00000281172_length(amino acids)=820AA_BP=43
MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEQRKNYARDSVSSVSDISQYRVEHLTTFVLDRKDAMITVDDGIRKLK
LLDAKGKVWTQDMILQVDDRAVSLIDLESKNELENFPLNTIQHCQAVMHSCSYDSVLALVCKEPTQNKPDLHLFQCDEVKANLISEDIES
AISDSKGGKQKRRPDALRMISNADPSIPPPPRAPAPAPPGTVTQVDVRSRVAAWSAWAADQGDFEKPRQYHEQEETPEMMAARIDRDVQI
LNHILDDIEFFITKLQKAAEAFSELSKRKKNKKGKRKGPGEGVLTLRAKPPPPDEFLDCFQKFKHGFNLLAKLKSHIQNPSAADLVHFLF
TPLNMVVQATGGPELASSVLSPLLNKDTIDFLNYTVNGDERQLWMSLGGTWMKARAEWPKEQFIPPYVPRFRNGWEPPMLNFMGATMEQD
LYQLAESVANVAEHQRKQEIKRLSTEHSSVSEYHPADGYAFSSNIYTRGSHLDQGEAAVAFKPTSNRHIDRNYEPLKTQPKKYAKSKYDF
VARNNSELSVLKDDILEILDDRKQWWKVRNASGDSGFVPNNILDIVRPPESGLGRADPPYTHTIQKQRMEYGPRPADTPPAPSPPPTPAP
VPVPLPPSTPAPVPVSKVPANITRQNSSSSDSGGSIVRDSQRHKQLPVDRRKSQMEEVQDELIHRLTIGRSAAQKKFHVPRQNVPVINIT
YDSTPEDVKTWLQSKGFNPVTVNSLGVLNGAQLFSLNKDELRTVCPEGARVYSQITVQKAALEDSSGSSELQEIMRRRQEKISAAASDSG

--------------------------------------------------------------
>6549_6549_2_ARL13B-EPS8_ARL13B_chr3_93714788_ENST00000394222_EPS8_chr12_15823857_ENST00000543523_length(transcript)=3897nt_BP=405nt
CGCGGGGCTTTTCTTTAGCCGGGTCCCGCTAACTCGGCTACGGTGTATCTGCGTCTTTGGTCAGGTTGTTCCTTGGCTAAGAGGGCAGTC
GTCGCGGACCCACGCGGTTAGCAAGGCTTAGTGCTCGGGCCGGCCGCCTTCACTTCCCTCCCGGCTTTTCCTCCCGACTTATCCACTTTA
GGGGCGTCTCGGAGTGCCGGAGGCCCCCGGGGAAGAGCGGGGTGCCGGTGTCCGCTCCGGGCTCGGATGGGAAGTGGTGGGAGGAGCGAC
CCGGGATGTTCAGTCTGATGGCCAGTTGCTGCGGCTGGTTCAAGCGGTGGCGGGAGCCTGTCAGAAAGGTGACTCTTTTGATGGTGGGAC
TTGATAATGCTGGTAAAACCGCAACAGCAAAGGGAATCCAAGGAGAACAAAGGAAGAATTATGCACGGGACAGTGTCAGCAGTGTGTCAG
ATATATCTCAATACCGTGTTGAACACTTGACTACCTTTGTCCTGGATCGGAAAGATGCTATGATCACTGTTGATGATGGAATAAGGAAAT
TGAAATTGCTTGATGCCAAGGGCAAAGTGTGGACTCAAGATATGATTCTTCAAGTGGATGACAGAGCTGTGAGCCTGATTGATTTAGAAT
CAAAGAATGAACTGGAGAATTTTCCTTTAAACACAATCCAGCACTGCCAAGCTGTGATGCATTCATGCAGCTATGATTCAGTTCTTGCAC
TGGTGTGCAAAGAGCCAACCCAGAACAAGCCAGATCTTCATCTCTTCCAGTGTGATGAGGTTAAGGCAAACCTAATTAGTGAAGATATTG
AAAGTGCAATCAGTGACAGTAAAGGAGGGAAACAGAAGAGGCGGCCCGACGCCCTGAGGATGATTTCCAATGCAGACCCTAGTATACCGC
CTCCACCCAGAGCTCCTGCCCCTGCGCCCCCTGGGACCGTCACCCAGGTGGATGTTAGAAGTCGAGTGGCAGCCTGGTCTGCATGGGCAG
CCGACCAAGGGGACTTTGAGAAACCAAGGCAGTATCATGAGCAGGAAGAAACACCTGAGATGATGGCAGCCCGCATTGACAGAGATGTGC
AAATCTTAAACCACATTTTGGATGACATTGAATTTTTTATCACAAAACTCCAAAAAGCAGCAGAAGCATTTTCTGAGCTTTCTAAAAGGA
AGAAAAACAAGAAAGGTAAAAGGAAAGGACCAGGAGAGGGTGTTTTAACGCTGCGGGCAAAACCTCCACCTCCTGATGAATTTCTTGACT
GTTTCCAAAAGTTTAAACACGGATTTAACCTTCTGGCCAAACTGAAGTCTCATATTCAGAATCCTAGTGCTGCAGATTTGGTTCACTTTT
TGTTTACTCCATTAAATATGGTGGTGCAGGCAACAGGAGGTCCTGAACTAGCCAGTTCAGTACTTAGTCCCCTATTGAATAAGGACACAA
TTGATTTCTTAAATTATACTGTCAATGGTGATGAACGGCAGCTGTGGATGTCATTGGGAGGAACTTGGATGAAAGCCAGAGCAGAGTGGC
CAAAAGAACAGTTTATTCCACCATATGTTCCACGATTCCGCAATGGCTGGGAGCCCCCAATGCTGAACTTTATGGGAGCCACAATGGAAC
AAGATCTTTATCAACTGGCAGAATCTGTGGCAAATGTAGCAGAACATCAGCGCAAACAGGAAATAAAAAGATTATCCACAGAGCATTCCA
GTGTATCAGAGTATCATCCAGCCGATGGCTATGCGTTCAGTAGCAACATTTACACAAGAGGATCCCACCTGGACCAAGGGGAAGCTGCTG
TTGCTTTTAAGCCAACTTCTAATCGCCATATAGATAGAAATTATGAACCACTCAAAACACAACCCAAGAAATATGCCAAATCCAAGTATG
ACTTTGTAGCAAGGAACAACAGTGAGCTCTCGGTTCTAAAGGATGATATTTTAGAGATACTTGATGATCGGAAGCAATGGTGGAAAGTTC
GAAATGCAAGTGGAGACTCTGGATTTGTGCCAAATAACATTTTGGATATTGTGAGACCTCCAGAATCTGGATTGGGGCGTGCTGATCCAC
CTTATACTCATACTATACAGAAACAAAGGATGGAGTATGGCCCAAGACCAGCTGATACTCCCCCTGCTCCATCACCTCCTCCAACACCAG
CTCCTGTTCCTGTTCCCCTTCCCCCTTCCACTCCAGCACCTGTTCCTGTGTCAAAGGTCCCAGCAAATATAACACGTCAAAACAGCAGCT
CCAGTGACAGTGGTGGCAGTATCGTGCGAGACAGCCAGAGACACAAACAACTTCCGGTGGACCGAAGGAAATCTCAGATGGAGGAAGTGC
AAGATGAACTCATCCACAGACTGACCATTGGTCGGAGTGCCGCTCAGAAGAAATTCCATGTGCCACGGCAGAACGTGCCAGTTATCAATA
TCACTTACGACTCCACACCAGAGGATGTGAAGACGTGGTTACAGTCAAAGGGATTCAACCCTGTGACTGTCAATAGTCTTGGAGTATTAA
ATGGTGCACAACTTTTCTCTCTCAATAAGGATGAACTGAGGACAGTCTGCCCTGAAGGGGCGAGAGTCTATAGCCAAATCACTGTACAAA
AAGCTGCATTGGAGGATAGCAGTGGCAGCTCCGAGTTACAAGAAATTATGAGAAGACGACAGGAAAAAATCAGTGCTGCCGCTAGTGATT
CAGGAGTGGAATCTTTTGATGAAGGAAGCAGTCACTAATTTGTTTGTTTGTATTTAAACTCCATTGTTTTTGGCATTATTCCAACATGCT
TTGTTTTAAGAAGCCTTGAAGGGAATGTCAGATTCATTTTTCTTGATGTAATTTATCACCATAAAAAAAAACCCATGCAAACCTGAGTGA
GCACAGGATTTGCTTCTAGGCCCATTATTTTTATTAAAACTGAAAAAATTTAAACTGAATTTTTTGACCTTGGAAAATATTTTTCTTACT
TTACCAAGGTGAAGTTTCCTTAATTAGACTAATTATTTTATCCCCATCCCAGGGTATAAACAGGAATTGTTTTGATAGTGGTGGAGTTAT
TCACTGCAACAAAGCAACAATGTTGTCCATGATTCAAAATCTAAGCAGTTTCGATTTTGCCTGTGAATATGGTGTCTGTCATTCAGGGCA
TAGCTCACTGTAGGCTAGCCTCTGCTTACTTAAGTCTCTTCTCTGACATACTCAATGGAAGAATATTTAGATTTATTTAAAGTTCTTAAT
GCCAACAGTTTAAAAAAAAATTAAAACATTTGAATGAACTGTAAAGTACAGCCATACCTTGGACATGCAAATATAAATCTATGGAGCATT
CTCAAGAGAGTTTGTCATGGCTCTGTTGATTGCAACTCCTTGTATAGCTTGTATTTTGATTTAGTTTATATTCTGCTTATTATGTATACT
GTGTTCTTATATATGAGAAAGCACAAATGCGAAAGAGGTCATGTCTTCTCAAAATCTAGCAAAGGAAGTAGTCTGCATTGGTGTGCATTA
CAGTATTTTGCTTAATGAAAGCCTCAGTTCTGAATGTTGATATGAGTAGTTAAAAGGAAGTGGGGCCATTTTATGTGTTTATCTGTGTCA
AGTATTTCTGGTAATAAGAAGCACTTAATTTACACATATTTTAATCCTGTGAAAGATTCCACATAGAGAAAAGAAAGATACCTAACCTTC
AACAAATGTTATTTTTGGAAACACAATTTTTGTCATTAAATGTTATATTATTTCACATATATAAAACAGATGTTATGTAAGAATGTTGTA
TATTTTAACATAAATCATTTAGAGAAATTATCTAGATTCATTAATTTTCATAGTGCCTTTTTCACATGAGTCAGCTGGAAAGTCTGCAAT

>6549_6549_2_ARL13B-EPS8_ARL13B_chr3_93714788_ENST00000394222_EPS8_chr12_15823857_ENST00000543523_length(amino acids)=820AA_BP=43
MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEQRKNYARDSVSSVSDISQYRVEHLTTFVLDRKDAMITVDDGIRKLK
LLDAKGKVWTQDMILQVDDRAVSLIDLESKNELENFPLNTIQHCQAVMHSCSYDSVLALVCKEPTQNKPDLHLFQCDEVKANLISEDIES
AISDSKGGKQKRRPDALRMISNADPSIPPPPRAPAPAPPGTVTQVDVRSRVAAWSAWAADQGDFEKPRQYHEQEETPEMMAARIDRDVQI
LNHILDDIEFFITKLQKAAEAFSELSKRKKNKKGKRKGPGEGVLTLRAKPPPPDEFLDCFQKFKHGFNLLAKLKSHIQNPSAADLVHFLF
TPLNMVVQATGGPELASSVLSPLLNKDTIDFLNYTVNGDERQLWMSLGGTWMKARAEWPKEQFIPPYVPRFRNGWEPPMLNFMGATMEQD
LYQLAESVANVAEHQRKQEIKRLSTEHSSVSEYHPADGYAFSSNIYTRGSHLDQGEAAVAFKPTSNRHIDRNYEPLKTQPKKYAKSKYDF
VARNNSELSVLKDDILEILDDRKQWWKVRNASGDSGFVPNNILDIVRPPESGLGRADPPYTHTIQKQRMEYGPRPADTPPAPSPPPTPAP
VPVPLPPSTPAPVPVSKVPANITRQNSSSSDSGGSIVRDSQRHKQLPVDRRKSQMEEVQDELIHRLTIGRSAAQKKFHVPRQNVPVINIT
YDSTPEDVKTWLQSKGFNPVTVNSLGVLNGAQLFSLNKDELRTVCPEGARVYSQITVQKAALEDSSGSSELQEIMRRRQEKISAAASDSG

--------------------------------------------------------------
>6549_6549_3_ARL13B-EPS8_ARL13B_chr3_93714788_ENST00000394222_EPS8_chr12_15823857_ENST00000543612_length(transcript)=3072nt_BP=405nt
CGCGGGGCTTTTCTTTAGCCGGGTCCCGCTAACTCGGCTACGGTGTATCTGCGTCTTTGGTCAGGTTGTTCCTTGGCTAAGAGGGCAGTC
GTCGCGGACCCACGCGGTTAGCAAGGCTTAGTGCTCGGGCCGGCCGCCTTCACTTCCCTCCCGGCTTTTCCTCCCGACTTATCCACTTTA
GGGGCGTCTCGGAGTGCCGGAGGCCCCCGGGGAAGAGCGGGGTGCCGGTGTCCGCTCCGGGCTCGGATGGGAAGTGGTGGGAGGAGCGAC
CCGGGATGTTCAGTCTGATGGCCAGTTGCTGCGGCTGGTTCAAGCGGTGGCGGGAGCCTGTCAGAAAGGTGACTCTTTTGATGGTGGGAC
TTGATAATGCTGGTAAAACCGCAACAGCAAAGGGAATCCAAGGAGAACAAAGGAAGAATTATGCACGGGACAGTGTCAGCAGTGTGTCAG
ATATATCTCAATACCGTGTTGAACACTTGACTACCTTTGTCCTGGATCGGAAAGATGCTATGATCACTGTTGATGATGGAATAAGGAAAT
TGAAATTGCTTGATGCCAAGGGCAAAGTGTGGACTCAAGATATGATTCTTCAAGTGGATGACAGAGCTGTGAGCCTGATTGATTTAGAAT
CAAAGAATGAACTGGAGAATTTTCCTTTAAACACAATCCAGCACTGCCAAGCTGTGATGCATTCATGCAGCTATGATTCAGTTCTTGCAC
TGGTGTGCAAAGAGCCAACCCAGAACAAGCCAGATCTTCATCTCTTCCAGTGTGATGAGGTTAAGGCAAACCTAATTAGTGAAGATATTG
AAAGTGCAATCAGTGACAGTAAAGGAGGGAAACAGAAGAGGCGGCCCGACGCCCTGAGGATGATTTCCAATGCAGACCCTAGTATACCGC
CTCCACCCAGAGCTCCTGCCCCTGCGCCCCCTGGGACCGTCACCCAGGTGGATGTTAGAAGTCGAGTGGCAGCCTGGTCTGCATGGGCAG
CCGACCAAGGGGACTTTGAGAAACCAAGGCAGTATCATGAGCAGGAAGAAACACCTGAGATGATGGCAGCCCGCATTGACAGAGATGTGC
AAATCTTAAACCACATTTTGGATGACATTGAATTTTTTATCACAAAACTCCAAAAAGCAGCAGAAGCATTTTCTGAGCTTTCTAAAAGGA
AGAAAAACAAGAAAGGTAAAAGGAAAGGACCAGGAGAGGGTGTTTTAACGCTGCGGGCAAAACCTCCACCTCCTGATGAATTTCTTGACT
GTTTCCAAAAGTTTAAACACGGATTTAACCTTCTGGCCAAACTGAAGTCTCATATTCAGAATCCTAGTGCTGCAGATTTGGTTCACTTTT
TGTTTACTCCATTAAATATGGTGGTGCAGGCAACAGGAGGTCCTGAACTAGCCAGTTCAGTACTTAGTCCCCTATTGAATAAGGACACAA
TTGATTTCTTAAATTATACTGTCAATGGTGATGAACGGCAGCTGTGGATGTCATTGGGAGGAACTTGGATGAAAGCCAGAGCAGAGTGGC
CAAAAGAACAGTTTATTCCACCATATGTTCCACGATTCCGCAATGGCTGGGAGCCCCCAATGCTGAACTTTATGGGAGCCACAATGGAAC
AAGATCTTTATCAACTGGCAGAATCTGTGGCAAATGTAGCAGAACATCAGCGCAAACAGGAAATAAAAAGATTATCCACAGAGCATTCCA
GTGTATCAGAGTATCATCCAGCCGATGGCTATGCGTTCAGTAGCAACATTTACACAAGAGGATCCCACCTGGACCAAGGGGAAGCTGCTG
TTGCTTTTAAGCCAACTTCTAATCGCCATATAGATAGAAATTATGAACCACTCAAAACACAACCCAAGAAATATGCCAAATCCAAGTATG
ACTTTGTAGCAAGGAACAACAGTGAGCTCTCGGTTCTAAAGGATGATATTTTAGAGATACTTGATGATCGGAAGCAATGGTGGAAAGTTC
GAAATGCAAGTGGAGACTCTGGATTTGTGCCAAATAACATTTTGGATATTGTGAGACCTCCAGAATCTGGATTGGGGCGTGCTGATCCAC
CTTATACTCATACTATACAGAAACAAAGGATGGAGTATGGCCCAAGACCAGCTGATACTCCCCCTGCTCCATCACCTCCTCCAACACCAG
CTCCTGTTCCTGTTCCCCTTCCCCCTTCCACTCCAGCACCTGTTCCTGTGTCAAAGGTCCCAGCAAATATAACACGTCAAAACAGCAGCT
CCAGTGACAGTGGTGGCAGTATCGTGCGAGACAGCCAGAGACACAAACAACTTCCGGTGGACCGAAGGAAATCTCAGATGGAGGAAGTGC
AAGATGAACTCATCCACAGACTGACCATTGGTCGGAGTGCCGCTCAGAAGAAATTCCATGTGCCACGGCAGAACGTGCCAGTTATCAATA
TCACTTACGACTCCACACCAGAGGATGTGAAGACGTGGTTACAGTCAAAGGGATTCAACCCTGTGACTGTCAATAGTCTTGGAGTATTAA
ATGGTGCACAACTTTTCTCTCTCAATAAGGATGAACTGAGGACAGTCTGCCCTGAAGGGGCGAGAGTCTATAGCCAAATCACTGTACAAA
AAGCTGCATTGGAGGATAGCAGTGGCAGCTCCGAGTTACAAGAAATTATGAGAAGACGACAGGAAAAAATCAGTGCTGCCGCTAGTGATT
CAGGAGTGGAATCTTTTGATGAAGGAAGCAGTCACTAATTTGTTTGTTTGTATTTAAACTCCATTGTTTTTGGCATTATTCCAACATGCT
TTGTTTTAAGAAGCCTTGAAGGGAATGTCAGATTCATTTTTCTTGATGTAATTTATCACCATAAAAAAAAACCCATGCAAACCTGAGTGA
GCACAGGATTTGCTTCTAGGCCCATTATTTTTATTAAAACTGAAAAAATTTAAACTGAATTTTTTGACCTTGGAAAATATTTTTCTTACT
TTACCAAGGTGAAGTTTCCTTAATTAGACTAATTATTTTATCCCCATCCCAGGGTATAAACAGGAATTGTTTTGATAGTGGTGGAGTTAT

>6549_6549_3_ARL13B-EPS8_ARL13B_chr3_93714788_ENST00000394222_EPS8_chr12_15823857_ENST00000543612_length(amino acids)=820AA_BP=43
MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEQRKNYARDSVSSVSDISQYRVEHLTTFVLDRKDAMITVDDGIRKLK
LLDAKGKVWTQDMILQVDDRAVSLIDLESKNELENFPLNTIQHCQAVMHSCSYDSVLALVCKEPTQNKPDLHLFQCDEVKANLISEDIES
AISDSKGGKQKRRPDALRMISNADPSIPPPPRAPAPAPPGTVTQVDVRSRVAAWSAWAADQGDFEKPRQYHEQEETPEMMAARIDRDVQI
LNHILDDIEFFITKLQKAAEAFSELSKRKKNKKGKRKGPGEGVLTLRAKPPPPDEFLDCFQKFKHGFNLLAKLKSHIQNPSAADLVHFLF
TPLNMVVQATGGPELASSVLSPLLNKDTIDFLNYTVNGDERQLWMSLGGTWMKARAEWPKEQFIPPYVPRFRNGWEPPMLNFMGATMEQD
LYQLAESVANVAEHQRKQEIKRLSTEHSSVSEYHPADGYAFSSNIYTRGSHLDQGEAAVAFKPTSNRHIDRNYEPLKTQPKKYAKSKYDF
VARNNSELSVLKDDILEILDDRKQWWKVRNASGDSGFVPNNILDIVRPPESGLGRADPPYTHTIQKQRMEYGPRPADTPPAPSPPPTPAP
VPVPLPPSTPAPVPVSKVPANITRQNSSSSDSGGSIVRDSQRHKQLPVDRRKSQMEEVQDELIHRLTIGRSAAQKKFHVPRQNVPVINIT
YDSTPEDVKTWLQSKGFNPVTVNSLGVLNGAQLFSLNKDELRTVCPEGARVYSQITVQKAALEDSSGSSELQEIMRRRQEKISAAASDSG

--------------------------------------------------------------
>6549_6549_4_ARL13B-EPS8_ARL13B_chr3_93714788_ENST00000471138_EPS8_chr12_15823857_ENST00000281172_length(transcript)=3887nt_BP=399nt
GCTTTTCTTTAGCCGGGTCCCGCTAACTCGGCTACGGTGTATCTGCGTCTTTGGTCAGGTTGTTCCTTGGCTAAGAGGGCAGTCGTCGCG
GACCCACGCGGTTAGCAAGGCTTAGTGCTCGGGCCGGCCGCCTTCACTTCCCTCCCGGCTTTTCCTCCCGACTTATCCACTTTAGGGGCG
TCTCGGAGTGCCGGAGGCCCCCGGGGAAGAGCGGGGTGCCGGTGTCCGCTCCGGGCTCGGATGGGAAGTGGTGGGAGGAGCGACCCGGGA
TGTTCAGTCTGATGGCCAGTTGCTGCGGCTGGTTCAAGCGGTGGCGGGAGCCTGTCAGAAAGGTGACTCTTTTGATGGTGGGACTTGATA
ATGCTGGTAAAACCGCAACAGCAAAGGGAATCCAAGGAGAACAAAGGAAGAATTATGCACGGGACAGTGTCAGCAGTGTGTCAGATATAT
CTCAATACCGTGTTGAACACTTGACTACCTTTGTCCTGGATCGGAAAGATGCTATGATCACTGTTGATGATGGAATAAGGAAATTGAAAT
TGCTTGATGCCAAGGGCAAAGTGTGGACTCAAGATATGATTCTTCAAGTGGATGACAGAGCTGTGAGCCTGATTGATTTAGAATCAAAGA
ATGAACTGGAGAATTTTCCTTTAAACACAATCCAGCACTGCCAAGCTGTGATGCATTCATGCAGCTATGATTCAGTTCTTGCACTGGTGT
GCAAAGAGCCAACCCAGAACAAGCCAGATCTTCATCTCTTCCAGTGTGATGAGGTTAAGGCAAACCTAATTAGTGAAGATATTGAAAGTG
CAATCAGTGACAGTAAAGGAGGGAAACAGAAGAGGCGGCCCGACGCCCTGAGGATGATTTCCAATGCAGACCCTAGTATACCGCCTCCAC
CCAGAGCTCCTGCCCCTGCGCCCCCTGGGACCGTCACCCAGGTGGATGTTAGAAGTCGAGTGGCAGCCTGGTCTGCATGGGCAGCCGACC
AAGGGGACTTTGAGAAACCAAGGCAGTATCATGAGCAGGAAGAAACACCTGAGATGATGGCAGCCCGCATTGACAGAGATGTGCAAATCT
TAAACCACATTTTGGATGACATTGAATTTTTTATCACAAAACTCCAAAAAGCAGCAGAAGCATTTTCTGAGCTTTCTAAAAGGAAGAAAA
ACAAGAAAGGTAAAAGGAAAGGACCAGGAGAGGGTGTTTTAACGCTGCGGGCAAAACCTCCACCTCCTGATGAATTTCTTGACTGTTTCC
AAAAGTTTAAACACGGATTTAACCTTCTGGCCAAACTGAAGTCTCATATTCAGAATCCTAGTGCTGCAGATTTGGTTCACTTTTTGTTTA
CTCCATTAAATATGGTGGTGCAGGCAACAGGAGGTCCTGAACTAGCCAGTTCAGTACTTAGTCCCCTATTGAATAAGGACACAATTGATT
TCTTAAATTATACTGTCAATGGTGATGAACGGCAGCTGTGGATGTCATTGGGAGGAACTTGGATGAAAGCCAGAGCAGAGTGGCCAAAAG
AACAGTTTATTCCACCATATGTTCCACGATTCCGCAATGGCTGGGAGCCCCCAATGCTGAACTTTATGGGAGCCACAATGGAACAAGATC
TTTATCAACTGGCAGAATCTGTGGCAAATGTAGCAGAACATCAGCGCAAACAGGAAATAAAAAGATTATCCACAGAGCATTCCAGTGTAT
CAGAGTATCATCCAGCCGATGGCTATGCGTTCAGTAGCAACATTTACACAAGAGGATCCCACCTGGACCAAGGGGAAGCTGCTGTTGCTT
TTAAGCCAACTTCTAATCGCCATATAGATAGAAATTATGAACCACTCAAAACACAACCCAAGAAATATGCCAAATCCAAGTATGACTTTG
TAGCAAGGAACAACAGTGAGCTCTCGGTTCTAAAGGATGATATTTTAGAGATACTTGATGATCGGAAGCAATGGTGGAAAGTTCGAAATG
CAAGTGGAGACTCTGGATTTGTGCCAAATAACATTTTGGATATTGTGAGACCTCCAGAATCTGGATTGGGGCGTGCTGATCCACCTTATA
CTCATACTATACAGAAACAAAGGATGGAGTATGGCCCAAGACCAGCTGATACTCCCCCTGCTCCATCACCTCCTCCAACACCAGCTCCTG
TTCCTGTTCCCCTTCCCCCTTCCACTCCAGCACCTGTTCCTGTGTCAAAGGTCCCAGCAAATATAACACGTCAAAACAGCAGCTCCAGTG
ACAGTGGTGGCAGTATCGTGCGAGACAGCCAGAGACACAAACAACTTCCGGTGGACCGAAGGAAATCTCAGATGGAGGAAGTGCAAGATG
AACTCATCCACAGACTGACCATTGGTCGGAGTGCCGCTCAGAAGAAATTCCATGTGCCACGGCAGAACGTGCCAGTTATCAATATCACTT
ACGACTCCACACCAGAGGATGTGAAGACGTGGTTACAGTCAAAGGGATTCAACCCTGTGACTGTCAATAGTCTTGGAGTATTAAATGGTG
CACAACTTTTCTCTCTCAATAAGGATGAACTGAGGACAGTCTGCCCTGAAGGGGCGAGAGTCTATAGCCAAATCACTGTACAAAAAGCTG
CATTGGAGGATAGCAGTGGCAGCTCCGAGTTACAAGAAATTATGAGAAGACGACAGGAAAAAATCAGTGCTGCCGCTAGTGATTCAGGAG
TGGAATCTTTTGATGAAGGAAGCAGTCACTAATTTGTTTGTTTGTATTTAAACTCCATTGTTTTTGGCATTATTCCAACATGCTTTGTTT
TAAGAAGCCTTGAAGGGAATGTCAGATTCATTTTTCTTGATGTAATTTATCACCATAAAAAAAAACCCATGCAAACCTGAGTGAGCACAG
GATTTGCTTCTAGGCCCATTATTTTTATTAAAACTGAAAAAATTTAAACTGAATTTTTTGACCTTGGAAAATATTTTTCTTACTTTACCA
AGGTGAAGTTTCCTTAATTAGACTAATTATTTTATCCCCATCCCAGGGTATAAACAGGAATTGTTTTGATAGTGGTGGAGTTATTCACTG
CAACAAAGCAACAATGTTGTCCATGATTCAAAATCTAAGCAGTTTCGATTTTGCCTGTGAATATGGTGTCTGTCATTCAGGGCATAGCTC
ACTGTAGGCTAGCCTCTGCTTACTTAAGTCTCTTCTCTGACATACTCAATGGAAGAATATTTAGATTTATTTAAAGTTCTTAATGCCAAC
AGTTTAAAAAAAAATTAAAACATTTGAATGAACTGTAAAGTACAGCCATACCTTGGACATGCAAATATAAATCTATGGAGCATTCTCAAG
AGAGTTTGTCATGGCTCTGTTGATTGCAACTCCTTGTATAGCTTGTATTTTGATTTAGTTTATATTCTGCTTATTATGTATACTGTGTTC
TTATATATGAGAAAGCACAAATGCGAAAGAGGTCATGTCTTCTCAAAATCTAGCAAAGGAAGTAGTCTGCATTGGTGTGCATTACAGTAT
TTTGCTTAATGAAAGCCTCAGTTCTGAATGTTGATATGAGTAGTTAAAAGGAAGTGGGGCCATTTTATGTGTTTATCTGTGTCAAGTATT
TCTGGTAATAAGAAGCACTTAATTTACACATATTTTAATCCTGTGAAAGATTCCACATAGAGAAAAGAAAGATACCTAACCTTCAACAAA
TGTTATTTTTGGAAACACAATTTTTGTCATTAAATGTTATATTATTTCACATATATAAAACAGATGTTATGTAAGAATGTTGTATATTTT
AACATAAATCATTTAGAGAAATTATCTAGATTCATTAATTTTCATAGTGCCTTTTTCACATGAGTCAGCTGGAAAGTCTGCAATAAACAG

>6549_6549_4_ARL13B-EPS8_ARL13B_chr3_93714788_ENST00000471138_EPS8_chr12_15823857_ENST00000281172_length(amino acids)=820AA_BP=43
MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEQRKNYARDSVSSVSDISQYRVEHLTTFVLDRKDAMITVDDGIRKLK
LLDAKGKVWTQDMILQVDDRAVSLIDLESKNELENFPLNTIQHCQAVMHSCSYDSVLALVCKEPTQNKPDLHLFQCDEVKANLISEDIES
AISDSKGGKQKRRPDALRMISNADPSIPPPPRAPAPAPPGTVTQVDVRSRVAAWSAWAADQGDFEKPRQYHEQEETPEMMAARIDRDVQI
LNHILDDIEFFITKLQKAAEAFSELSKRKKNKKGKRKGPGEGVLTLRAKPPPPDEFLDCFQKFKHGFNLLAKLKSHIQNPSAADLVHFLF
TPLNMVVQATGGPELASSVLSPLLNKDTIDFLNYTVNGDERQLWMSLGGTWMKARAEWPKEQFIPPYVPRFRNGWEPPMLNFMGATMEQD
LYQLAESVANVAEHQRKQEIKRLSTEHSSVSEYHPADGYAFSSNIYTRGSHLDQGEAAVAFKPTSNRHIDRNYEPLKTQPKKYAKSKYDF
VARNNSELSVLKDDILEILDDRKQWWKVRNASGDSGFVPNNILDIVRPPESGLGRADPPYTHTIQKQRMEYGPRPADTPPAPSPPPTPAP
VPVPLPPSTPAPVPVSKVPANITRQNSSSSDSGGSIVRDSQRHKQLPVDRRKSQMEEVQDELIHRLTIGRSAAQKKFHVPRQNVPVINIT
YDSTPEDVKTWLQSKGFNPVTVNSLGVLNGAQLFSLNKDELRTVCPEGARVYSQITVQKAALEDSSGSSELQEIMRRRQEKISAAASDSG

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>6549_6549_5_ARL13B-EPS8_ARL13B_chr3_93714788_ENST00000471138_EPS8_chr12_15823857_ENST00000543523_length(transcript)=3891nt_BP=399nt
GCTTTTCTTTAGCCGGGTCCCGCTAACTCGGCTACGGTGTATCTGCGTCTTTGGTCAGGTTGTTCCTTGGCTAAGAGGGCAGTCGTCGCG
GACCCACGCGGTTAGCAAGGCTTAGTGCTCGGGCCGGCCGCCTTCACTTCCCTCCCGGCTTTTCCTCCCGACTTATCCACTTTAGGGGCG
TCTCGGAGTGCCGGAGGCCCCCGGGGAAGAGCGGGGTGCCGGTGTCCGCTCCGGGCTCGGATGGGAAGTGGTGGGAGGAGCGACCCGGGA
TGTTCAGTCTGATGGCCAGTTGCTGCGGCTGGTTCAAGCGGTGGCGGGAGCCTGTCAGAAAGGTGACTCTTTTGATGGTGGGACTTGATA
ATGCTGGTAAAACCGCAACAGCAAAGGGAATCCAAGGAGAACAAAGGAAGAATTATGCACGGGACAGTGTCAGCAGTGTGTCAGATATAT
CTCAATACCGTGTTGAACACTTGACTACCTTTGTCCTGGATCGGAAAGATGCTATGATCACTGTTGATGATGGAATAAGGAAATTGAAAT
TGCTTGATGCCAAGGGCAAAGTGTGGACTCAAGATATGATTCTTCAAGTGGATGACAGAGCTGTGAGCCTGATTGATTTAGAATCAAAGA
ATGAACTGGAGAATTTTCCTTTAAACACAATCCAGCACTGCCAAGCTGTGATGCATTCATGCAGCTATGATTCAGTTCTTGCACTGGTGT
GCAAAGAGCCAACCCAGAACAAGCCAGATCTTCATCTCTTCCAGTGTGATGAGGTTAAGGCAAACCTAATTAGTGAAGATATTGAAAGTG
CAATCAGTGACAGTAAAGGAGGGAAACAGAAGAGGCGGCCCGACGCCCTGAGGATGATTTCCAATGCAGACCCTAGTATACCGCCTCCAC
CCAGAGCTCCTGCCCCTGCGCCCCCTGGGACCGTCACCCAGGTGGATGTTAGAAGTCGAGTGGCAGCCTGGTCTGCATGGGCAGCCGACC
AAGGGGACTTTGAGAAACCAAGGCAGTATCATGAGCAGGAAGAAACACCTGAGATGATGGCAGCCCGCATTGACAGAGATGTGCAAATCT
TAAACCACATTTTGGATGACATTGAATTTTTTATCACAAAACTCCAAAAAGCAGCAGAAGCATTTTCTGAGCTTTCTAAAAGGAAGAAAA
ACAAGAAAGGTAAAAGGAAAGGACCAGGAGAGGGTGTTTTAACGCTGCGGGCAAAACCTCCACCTCCTGATGAATTTCTTGACTGTTTCC
AAAAGTTTAAACACGGATTTAACCTTCTGGCCAAACTGAAGTCTCATATTCAGAATCCTAGTGCTGCAGATTTGGTTCACTTTTTGTTTA
CTCCATTAAATATGGTGGTGCAGGCAACAGGAGGTCCTGAACTAGCCAGTTCAGTACTTAGTCCCCTATTGAATAAGGACACAATTGATT
TCTTAAATTATACTGTCAATGGTGATGAACGGCAGCTGTGGATGTCATTGGGAGGAACTTGGATGAAAGCCAGAGCAGAGTGGCCAAAAG
AACAGTTTATTCCACCATATGTTCCACGATTCCGCAATGGCTGGGAGCCCCCAATGCTGAACTTTATGGGAGCCACAATGGAACAAGATC
TTTATCAACTGGCAGAATCTGTGGCAAATGTAGCAGAACATCAGCGCAAACAGGAAATAAAAAGATTATCCACAGAGCATTCCAGTGTAT
CAGAGTATCATCCAGCCGATGGCTATGCGTTCAGTAGCAACATTTACACAAGAGGATCCCACCTGGACCAAGGGGAAGCTGCTGTTGCTT
TTAAGCCAACTTCTAATCGCCATATAGATAGAAATTATGAACCACTCAAAACACAACCCAAGAAATATGCCAAATCCAAGTATGACTTTG
TAGCAAGGAACAACAGTGAGCTCTCGGTTCTAAAGGATGATATTTTAGAGATACTTGATGATCGGAAGCAATGGTGGAAAGTTCGAAATG
CAAGTGGAGACTCTGGATTTGTGCCAAATAACATTTTGGATATTGTGAGACCTCCAGAATCTGGATTGGGGCGTGCTGATCCACCTTATA
CTCATACTATACAGAAACAAAGGATGGAGTATGGCCCAAGACCAGCTGATACTCCCCCTGCTCCATCACCTCCTCCAACACCAGCTCCTG
TTCCTGTTCCCCTTCCCCCTTCCACTCCAGCACCTGTTCCTGTGTCAAAGGTCCCAGCAAATATAACACGTCAAAACAGCAGCTCCAGTG
ACAGTGGTGGCAGTATCGTGCGAGACAGCCAGAGACACAAACAACTTCCGGTGGACCGAAGGAAATCTCAGATGGAGGAAGTGCAAGATG
AACTCATCCACAGACTGACCATTGGTCGGAGTGCCGCTCAGAAGAAATTCCATGTGCCACGGCAGAACGTGCCAGTTATCAATATCACTT
ACGACTCCACACCAGAGGATGTGAAGACGTGGTTACAGTCAAAGGGATTCAACCCTGTGACTGTCAATAGTCTTGGAGTATTAAATGGTG
CACAACTTTTCTCTCTCAATAAGGATGAACTGAGGACAGTCTGCCCTGAAGGGGCGAGAGTCTATAGCCAAATCACTGTACAAAAAGCTG
CATTGGAGGATAGCAGTGGCAGCTCCGAGTTACAAGAAATTATGAGAAGACGACAGGAAAAAATCAGTGCTGCCGCTAGTGATTCAGGAG
TGGAATCTTTTGATGAAGGAAGCAGTCACTAATTTGTTTGTTTGTATTTAAACTCCATTGTTTTTGGCATTATTCCAACATGCTTTGTTT
TAAGAAGCCTTGAAGGGAATGTCAGATTCATTTTTCTTGATGTAATTTATCACCATAAAAAAAAACCCATGCAAACCTGAGTGAGCACAG
GATTTGCTTCTAGGCCCATTATTTTTATTAAAACTGAAAAAATTTAAACTGAATTTTTTGACCTTGGAAAATATTTTTCTTACTTTACCA
AGGTGAAGTTTCCTTAATTAGACTAATTATTTTATCCCCATCCCAGGGTATAAACAGGAATTGTTTTGATAGTGGTGGAGTTATTCACTG
CAACAAAGCAACAATGTTGTCCATGATTCAAAATCTAAGCAGTTTCGATTTTGCCTGTGAATATGGTGTCTGTCATTCAGGGCATAGCTC
ACTGTAGGCTAGCCTCTGCTTACTTAAGTCTCTTCTCTGACATACTCAATGGAAGAATATTTAGATTTATTTAAAGTTCTTAATGCCAAC
AGTTTAAAAAAAAATTAAAACATTTGAATGAACTGTAAAGTACAGCCATACCTTGGACATGCAAATATAAATCTATGGAGCATTCTCAAG
AGAGTTTGTCATGGCTCTGTTGATTGCAACTCCTTGTATAGCTTGTATTTTGATTTAGTTTATATTCTGCTTATTATGTATACTGTGTTC
TTATATATGAGAAAGCACAAATGCGAAAGAGGTCATGTCTTCTCAAAATCTAGCAAAGGAAGTAGTCTGCATTGGTGTGCATTACAGTAT
TTTGCTTAATGAAAGCCTCAGTTCTGAATGTTGATATGAGTAGTTAAAAGGAAGTGGGGCCATTTTATGTGTTTATCTGTGTCAAGTATT
TCTGGTAATAAGAAGCACTTAATTTACACATATTTTAATCCTGTGAAAGATTCCACATAGAGAAAAGAAAGATACCTAACCTTCAACAAA
TGTTATTTTTGGAAACACAATTTTTGTCATTAAATGTTATATTATTTCACATATATAAAACAGATGTTATGTAAGAATGTTGTATATTTT
AACATAAATCATTTAGAGAAATTATCTAGATTCATTAATTTTCATAGTGCCTTTTTCACATGAGTCAGCTGGAAAGTCTGCAATAAACAG

>6549_6549_5_ARL13B-EPS8_ARL13B_chr3_93714788_ENST00000471138_EPS8_chr12_15823857_ENST00000543523_length(amino acids)=820AA_BP=43
MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEQRKNYARDSVSSVSDISQYRVEHLTTFVLDRKDAMITVDDGIRKLK
LLDAKGKVWTQDMILQVDDRAVSLIDLESKNELENFPLNTIQHCQAVMHSCSYDSVLALVCKEPTQNKPDLHLFQCDEVKANLISEDIES
AISDSKGGKQKRRPDALRMISNADPSIPPPPRAPAPAPPGTVTQVDVRSRVAAWSAWAADQGDFEKPRQYHEQEETPEMMAARIDRDVQI
LNHILDDIEFFITKLQKAAEAFSELSKRKKNKKGKRKGPGEGVLTLRAKPPPPDEFLDCFQKFKHGFNLLAKLKSHIQNPSAADLVHFLF
TPLNMVVQATGGPELASSVLSPLLNKDTIDFLNYTVNGDERQLWMSLGGTWMKARAEWPKEQFIPPYVPRFRNGWEPPMLNFMGATMEQD
LYQLAESVANVAEHQRKQEIKRLSTEHSSVSEYHPADGYAFSSNIYTRGSHLDQGEAAVAFKPTSNRHIDRNYEPLKTQPKKYAKSKYDF
VARNNSELSVLKDDILEILDDRKQWWKVRNASGDSGFVPNNILDIVRPPESGLGRADPPYTHTIQKQRMEYGPRPADTPPAPSPPPTPAP
VPVPLPPSTPAPVPVSKVPANITRQNSSSSDSGGSIVRDSQRHKQLPVDRRKSQMEEVQDELIHRLTIGRSAAQKKFHVPRQNVPVINIT
YDSTPEDVKTWLQSKGFNPVTVNSLGVLNGAQLFSLNKDELRTVCPEGARVYSQITVQKAALEDSSGSSELQEIMRRRQEKISAAASDSG

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>6549_6549_6_ARL13B-EPS8_ARL13B_chr3_93714788_ENST00000471138_EPS8_chr12_15823857_ENST00000543612_length(transcript)=3066nt_BP=399nt
GCTTTTCTTTAGCCGGGTCCCGCTAACTCGGCTACGGTGTATCTGCGTCTTTGGTCAGGTTGTTCCTTGGCTAAGAGGGCAGTCGTCGCG
GACCCACGCGGTTAGCAAGGCTTAGTGCTCGGGCCGGCCGCCTTCACTTCCCTCCCGGCTTTTCCTCCCGACTTATCCACTTTAGGGGCG
TCTCGGAGTGCCGGAGGCCCCCGGGGAAGAGCGGGGTGCCGGTGTCCGCTCCGGGCTCGGATGGGAAGTGGTGGGAGGAGCGACCCGGGA
TGTTCAGTCTGATGGCCAGTTGCTGCGGCTGGTTCAAGCGGTGGCGGGAGCCTGTCAGAAAGGTGACTCTTTTGATGGTGGGACTTGATA
ATGCTGGTAAAACCGCAACAGCAAAGGGAATCCAAGGAGAACAAAGGAAGAATTATGCACGGGACAGTGTCAGCAGTGTGTCAGATATAT
CTCAATACCGTGTTGAACACTTGACTACCTTTGTCCTGGATCGGAAAGATGCTATGATCACTGTTGATGATGGAATAAGGAAATTGAAAT
TGCTTGATGCCAAGGGCAAAGTGTGGACTCAAGATATGATTCTTCAAGTGGATGACAGAGCTGTGAGCCTGATTGATTTAGAATCAAAGA
ATGAACTGGAGAATTTTCCTTTAAACACAATCCAGCACTGCCAAGCTGTGATGCATTCATGCAGCTATGATTCAGTTCTTGCACTGGTGT
GCAAAGAGCCAACCCAGAACAAGCCAGATCTTCATCTCTTCCAGTGTGATGAGGTTAAGGCAAACCTAATTAGTGAAGATATTGAAAGTG
CAATCAGTGACAGTAAAGGAGGGAAACAGAAGAGGCGGCCCGACGCCCTGAGGATGATTTCCAATGCAGACCCTAGTATACCGCCTCCAC
CCAGAGCTCCTGCCCCTGCGCCCCCTGGGACCGTCACCCAGGTGGATGTTAGAAGTCGAGTGGCAGCCTGGTCTGCATGGGCAGCCGACC
AAGGGGACTTTGAGAAACCAAGGCAGTATCATGAGCAGGAAGAAACACCTGAGATGATGGCAGCCCGCATTGACAGAGATGTGCAAATCT
TAAACCACATTTTGGATGACATTGAATTTTTTATCACAAAACTCCAAAAAGCAGCAGAAGCATTTTCTGAGCTTTCTAAAAGGAAGAAAA
ACAAGAAAGGTAAAAGGAAAGGACCAGGAGAGGGTGTTTTAACGCTGCGGGCAAAACCTCCACCTCCTGATGAATTTCTTGACTGTTTCC
AAAAGTTTAAACACGGATTTAACCTTCTGGCCAAACTGAAGTCTCATATTCAGAATCCTAGTGCTGCAGATTTGGTTCACTTTTTGTTTA
CTCCATTAAATATGGTGGTGCAGGCAACAGGAGGTCCTGAACTAGCCAGTTCAGTACTTAGTCCCCTATTGAATAAGGACACAATTGATT
TCTTAAATTATACTGTCAATGGTGATGAACGGCAGCTGTGGATGTCATTGGGAGGAACTTGGATGAAAGCCAGAGCAGAGTGGCCAAAAG
AACAGTTTATTCCACCATATGTTCCACGATTCCGCAATGGCTGGGAGCCCCCAATGCTGAACTTTATGGGAGCCACAATGGAACAAGATC
TTTATCAACTGGCAGAATCTGTGGCAAATGTAGCAGAACATCAGCGCAAACAGGAAATAAAAAGATTATCCACAGAGCATTCCAGTGTAT
CAGAGTATCATCCAGCCGATGGCTATGCGTTCAGTAGCAACATTTACACAAGAGGATCCCACCTGGACCAAGGGGAAGCTGCTGTTGCTT
TTAAGCCAACTTCTAATCGCCATATAGATAGAAATTATGAACCACTCAAAACACAACCCAAGAAATATGCCAAATCCAAGTATGACTTTG
TAGCAAGGAACAACAGTGAGCTCTCGGTTCTAAAGGATGATATTTTAGAGATACTTGATGATCGGAAGCAATGGTGGAAAGTTCGAAATG
CAAGTGGAGACTCTGGATTTGTGCCAAATAACATTTTGGATATTGTGAGACCTCCAGAATCTGGATTGGGGCGTGCTGATCCACCTTATA
CTCATACTATACAGAAACAAAGGATGGAGTATGGCCCAAGACCAGCTGATACTCCCCCTGCTCCATCACCTCCTCCAACACCAGCTCCTG
TTCCTGTTCCCCTTCCCCCTTCCACTCCAGCACCTGTTCCTGTGTCAAAGGTCCCAGCAAATATAACACGTCAAAACAGCAGCTCCAGTG
ACAGTGGTGGCAGTATCGTGCGAGACAGCCAGAGACACAAACAACTTCCGGTGGACCGAAGGAAATCTCAGATGGAGGAAGTGCAAGATG
AACTCATCCACAGACTGACCATTGGTCGGAGTGCCGCTCAGAAGAAATTCCATGTGCCACGGCAGAACGTGCCAGTTATCAATATCACTT
ACGACTCCACACCAGAGGATGTGAAGACGTGGTTACAGTCAAAGGGATTCAACCCTGTGACTGTCAATAGTCTTGGAGTATTAAATGGTG
CACAACTTTTCTCTCTCAATAAGGATGAACTGAGGACAGTCTGCCCTGAAGGGGCGAGAGTCTATAGCCAAATCACTGTACAAAAAGCTG
CATTGGAGGATAGCAGTGGCAGCTCCGAGTTACAAGAAATTATGAGAAGACGACAGGAAAAAATCAGTGCTGCCGCTAGTGATTCAGGAG
TGGAATCTTTTGATGAAGGAAGCAGTCACTAATTTGTTTGTTTGTATTTAAACTCCATTGTTTTTGGCATTATTCCAACATGCTTTGTTT
TAAGAAGCCTTGAAGGGAATGTCAGATTCATTTTTCTTGATGTAATTTATCACCATAAAAAAAAACCCATGCAAACCTGAGTGAGCACAG
GATTTGCTTCTAGGCCCATTATTTTTATTAAAACTGAAAAAATTTAAACTGAATTTTTTGACCTTGGAAAATATTTTTCTTACTTTACCA
AGGTGAAGTTTCCTTAATTAGACTAATTATTTTATCCCCATCCCAGGGTATAAACAGGAATTGTTTTGATAGTGGTGGAGTTATTCACTG

>6549_6549_6_ARL13B-EPS8_ARL13B_chr3_93714788_ENST00000471138_EPS8_chr12_15823857_ENST00000543612_length(amino acids)=820AA_BP=43
MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEQRKNYARDSVSSVSDISQYRVEHLTTFVLDRKDAMITVDDGIRKLK
LLDAKGKVWTQDMILQVDDRAVSLIDLESKNELENFPLNTIQHCQAVMHSCSYDSVLALVCKEPTQNKPDLHLFQCDEVKANLISEDIES
AISDSKGGKQKRRPDALRMISNADPSIPPPPRAPAPAPPGTVTQVDVRSRVAAWSAWAADQGDFEKPRQYHEQEETPEMMAARIDRDVQI
LNHILDDIEFFITKLQKAAEAFSELSKRKKNKKGKRKGPGEGVLTLRAKPPPPDEFLDCFQKFKHGFNLLAKLKSHIQNPSAADLVHFLF
TPLNMVVQATGGPELASSVLSPLLNKDTIDFLNYTVNGDERQLWMSLGGTWMKARAEWPKEQFIPPYVPRFRNGWEPPMLNFMGATMEQD
LYQLAESVANVAEHQRKQEIKRLSTEHSSVSEYHPADGYAFSSNIYTRGSHLDQGEAAVAFKPTSNRHIDRNYEPLKTQPKKYAKSKYDF
VARNNSELSVLKDDILEILDDRKQWWKVRNASGDSGFVPNNILDIVRPPESGLGRADPPYTHTIQKQRMEYGPRPADTPPAPSPPPTPAP
VPVPLPPSTPAPVPVSKVPANITRQNSSSSDSGGSIVRDSQRHKQLPVDRRKSQMEEVQDELIHRLTIGRSAAQKKFHVPRQNVPVINIT
YDSTPEDVKTWLQSKGFNPVTVNSLGVLNGAQLFSLNKDELRTVCPEGARVYSQITVQKAALEDSSGSSELQEIMRRRQEKISAAASDSG

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Fusion Gene PPI Analysis for ARL13B-EPS8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARL13B-EPS8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARL13B-EPS8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARL13BC2676771JOUBERT SYNDROME 8 (disorder)4CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneARL13BC0431399Familial aplasia of the vermis1ORPHANET
HgeneARL13BC3714756Intellectual Disability1GENOMICS_ENGLAND
HgeneARL13BC4551568Joubert syndrome 11ORPHANET
TgeneC1846647DEAFNESS, AUTOSOMAL RECESSIVE (disorder)6CLINGEN
TgeneC0027626Neoplasm Invasiveness1CTD_human
TgeneC1857810Deafness, prelingual, profound (affects all frequencies)1GENOMICS_ENGLAND
TgeneC3892050DEAFNESS, AUTOSOMAL RECESSIVE 1021CTD_human;GENOMICS_ENGLAND