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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C4orf46-FAM188A (FusionGDB2 ID:HG201725TG80013)

Fusion Gene Summary for C4orf46-FAM188A

check button Fusion gene summary
Fusion gene informationFusion gene name: C4orf46-FAM188A
Fusion gene ID: hg201725tg80013
HgeneTgene
Gene symbol

C4orf46

FAM188A

Gene ID

201725

80013

Gene namechromosome 4 open reading frame 46MINDY lysine 48 deubiquitinase 3
SynonymsRCDG1C10orf97|CARP|DERP5|FAM188A|MST126|MSTP126|my042
Cytomap('C4orf46')('FAM188A')

4q32.1

10p13

Type of geneprotein-codingprotein-coding
Descriptionrenal cancer differentiation gene 1 proteinubiquitin carboxyl-terminal hydrolase MINDY-3CARD-containing proteinMINDY deubiquitinase 3caspase recruitment domain containing pro-apoptotic proteindermal papilla-derived protein 5deubiquitinating enzyme MINDY-3family with sequence similarity 188 m
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000379205, ENST00000508457, 
ENST00000508836, 
Fusion gene scores* DoF score2 X 2 X 1=46 X 3 X 5=90
# samples 26
** MAII scorelog2(2/4*10)=2.32192809488736log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C4orf46 [Title/Abstract] AND FAM188A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC4orf46(159592767)-FAM188A(15824225), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across C4orf46 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across FAM188A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for C4orf46-FAM188A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379205ENST00000378036C4orf46chr4159592767-FAM188Achr1015824225-0.012585050.9874149
ENST00000508457ENST00000378036C4orf46chr4159592767-FAM188Achr1015824225-0.0088809530.9911191

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Fusion Genomic Features for C4orf46-FAM188A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for C4orf46-FAM188A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:159592767/chr10:15824225)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for C4orf46-FAM188A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11817_11817_1_C4orf46-FAM188A_C4orf46_chr4_159592767_ENST00000379205_FAM188A_chr10_15824225_ENST00000378036_length(transcript)=1475nt_BP=431nt
GCCCTTCGAGATCGATTGGAGGCTCGCGCAGGAGCCGTGAGTTGCCTAAGGTGAATTGACTCATATGATTGGCTGTCCCGAAAAATGAAA
CGTCTTTGTGGTCCGGGGCTGAGACCCACGAGGAGACTGGGCGGGATTTCTGGCGTTAGGAGGCGGGGCCTTTCGGCTTTGGGCGCGAGT
GGTTAAAAGACAGTTGGTGTCGGTTCGGCTTCTCGGGTCGGATTCCGCGGTCCCAACCCTTCCCCATGGCCGACCCTGAGGAGTTGCAGG
TTTCTTCGCCGCCCCCGCCGCCTCCCTCTTCTCCCTCCTCTTCAGACGCCTCTGCAGCATCTTCCCCGGGCGGCCCAGTGAGTTTGGGCT
GGCCAGTTCCGAGCAGGAGCAGCGGCCCAACGGTGGACCAGCTGGAGGAAGTGGAGCTGCAGATCGGAGACGGCTCCAGTGGTCCAGAAT
CTTTTACTGTCTACCACTACAATGGATTGAAGCAGTCAAATTATAATGAAAAGGTCATGTACGTAGAAGGGACTGCAGTTGTGATGGGTT
TTGAAGATCCCATGCTACAGACAGATGACACTCCTATTAAACGCTGTCTGCAAACCAAATGGCCATACATTGAGTTACTCTGGACCACAG
ATCGCTCTCCTTCACTAAATTAATTTGTCTAAGTATTTATAAGGAAGATCTTAATAACAGATGTTGAAAGAAGGAGTCAAGACTGGCAAT
TGGCTGGATTAAGCTAAACACTGGTATCACTGATTAACTGTAAATAACAATTAAAAACACATTTTCAGTGTTTATGATATGTTTAAATTA
TTTGTCCTAAAGCTTTATGTTAAAGATTATCCTATTTTACCCCTTCGTGTGAAATTTACTAGCAAAATTAAGCTTTCATCAAAGTTCATC
ACTTTTGCATTCAGATACTTGGTCATTTACTTACCAAATTACAAACGCAATACTACAGCATTTGTATATTAAGTATCACAGTTACTATTG
ATAAACTACTTTTGGGTTTTATTTCATTGAGGCACTTTTTTTATTGTTTGAATGATTCCGGCTTGTAATATATCAGCCTCTACAATGAAA
TGCAGAAGAGTTCATTTTTCTAAGATCTGTTTTTCATTAGAAATATTGACAAATAACACATTGTCAACCTGGATCCTTTGACAATTTACT
TAACTCTGGCATGTTCACAAAAAGTAGAAACTCTAAGAGACCATTACCATTTATTCACAGATGTATAGGGGATGTATTCTAAAAACTGAC
AGAAAAGAGAATCTGATAGTCAACACTGTTAACTTTTACTGTGTAATTGCCAAATACACTTTTCCAAATTTGTCCCAACAGCCCTGTAAG
CCAGCTTTCTTCTATATTTATAAACACGATAAATGCATGAGAAGATCTGTTATTACATTAGTATATTACGTTATTTATTATGATCCTAGT

>11817_11817_1_C4orf46-FAM188A_C4orf46_chr4_159592767_ENST00000379205_FAM188A_chr10_15824225_ENST00000378036_length(amino acids)=135AA_BP=62
MADPEELQVSSPPPPPPSSPSSSDASAASSPGGPVSLGWPVPSRSSGPTVDQLEEVELQIGDGSSGPESFTVYHYNGLKQSNYNEKVMYV

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>11817_11817_2_C4orf46-FAM188A_C4orf46_chr4_159592767_ENST00000508457_FAM188A_chr10_15824225_ENST00000378036_length(transcript)=1321nt_BP=277nt
GGGGCCTTTCGGCTTTGGGCGCGAGTGGTTAAAAGACAGTTGGTGTCGGTTCGGCTTCTCGGGTCGGATTCCGCGGTCCCAACCCTTCCC
CATGGCCGACCCTGAGGAGTTGCAGGTTTCTTCGCCGCCCCCGCCGCCTCCCTCTTCTCCCTCCTCTTCAGACGCCTCTGCAGCATCTTC
CCCGGGCGGCCCAGTGAGTTTGGGCTGGCCAGTTCCGAGCAGGAGCAGCGGCCCAACGGTGGACCAGCTGGAGGAAGTGGAGCTGCAGAT
CGGAGACGGCTCCAGTGGTCCAGAATCTTTTACTGTCTACCACTACAATGGATTGAAGCAGTCAAATTATAATGAAAAGGTCATGTACGT
AGAAGGGACTGCAGTTGTGATGGGTTTTGAAGATCCCATGCTACAGACAGATGACACTCCTATTAAACGCTGTCTGCAAACCAAATGGCC
ATACATTGAGTTACTCTGGACCACAGATCGCTCTCCTTCACTAAATTAATTTGTCTAAGTATTTATAAGGAAGATCTTAATAACAGATGT
TGAAAGAAGGAGTCAAGACTGGCAATTGGCTGGATTAAGCTAAACACTGGTATCACTGATTAACTGTAAATAACAATTAAAAACACATTT
TCAGTGTTTATGATATGTTTAAATTATTTGTCCTAAAGCTTTATGTTAAAGATTATCCTATTTTACCCCTTCGTGTGAAATTTACTAGCA
AAATTAAGCTTTCATCAAAGTTCATCACTTTTGCATTCAGATACTTGGTCATTTACTTACCAAATTACAAACGCAATACTACAGCATTTG
TATATTAAGTATCACAGTTACTATTGATAAACTACTTTTGGGTTTTATTTCATTGAGGCACTTTTTTTATTGTTTGAATGATTCCGGCTT
GTAATATATCAGCCTCTACAATGAAATGCAGAAGAGTTCATTTTTCTAAGATCTGTTTTTCATTAGAAATATTGACAAATAACACATTGT
CAACCTGGATCCTTTGACAATTTACTTAACTCTGGCATGTTCACAAAAAGTAGAAACTCTAAGAGACCATTACCATTTATTCACAGATGT
ATAGGGGATGTATTCTAAAAACTGACAGAAAAGAGAATCTGATAGTCAACACTGTTAACTTTTACTGTGTAATTGCCAAATACACTTTTC
CAAATTTGTCCCAACAGCCCTGTAAGCCAGCTTTCTTCTATATTTATAAACACGATAAATGCATGAGAAGATCTGTTATTACATTAGTAT

>11817_11817_2_C4orf46-FAM188A_C4orf46_chr4_159592767_ENST00000508457_FAM188A_chr10_15824225_ENST00000378036_length(amino acids)=135AA_BP=62
MADPEELQVSSPPPPPPSSPSSSDASAASSPGGPVSLGWPVPSRSSGPTVDQLEEVELQIGDGSSGPESFTVYHYNGLKQSNYNEKVMYV

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Fusion Gene PPI Analysis for C4orf46-FAM188A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C4orf46-FAM188A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C4orf46-FAM188A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource