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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ENO1-MCUR1 (FusionGDB2 ID:HG2023TG63933)

Fusion Gene Summary for ENO1-MCUR1

check button Fusion gene summary
Fusion gene informationFusion gene name: ENO1-MCUR1
Fusion gene ID: hg2023tg63933
HgeneTgene
Gene symbol

ENO1

MCUR1

Gene ID

2023

63933

Gene nameenolase 1mitochondrial calcium uniporter regulator 1
SynonymsENO1L1|HEL-S-17|MPB1|NNE|PPHC6orf79|CCDC90A|FMP32
Cytomap('ENO1')('MCUR1')

1p36.23

6p23

Type of geneprotein-codingprotein-coding
Descriptionalpha-enolasec-myc promoter-binding protein-12-phospho-D-glycerate hydro-lyaseMYC promoter-binding protein 1alpha enolase like 1enolase 1, (alpha)enolase-alphaepididymis secretory protein Li 17non-neural enolasephosphopyruvate hydrataseplasminogmitochondrial calcium uniporter regulator 1MCU regulator 1coiled-coil domain containing 90Acoiled-coil domain-containing protein 90A, mitochondrialepididymis secretory sperm binding protein
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000234590, 
Fusion gene scores* DoF score31 X 31 X 10=96105 X 5 X 2=50
# samples 445
** MAII scorelog2(44/9610*10)=-4.44896100213645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/50*10)=0
Context

PubMed: ENO1 [Title/Abstract] AND MCUR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointENO1(8926441)-MCUR1(13788202), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneENO1

GO:0000122

negative regulation of transcription by RNA polymerase II

2005901

HgeneENO1

GO:0030308

negative regulation of cell growth

10082554

HgeneENO1

GO:0045892

negative regulation of transcription, DNA-templated

10082554

HgeneENO1

GO:0061621

canonical glycolysis

29775581

HgeneENO1

GO:1903298

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

15459207

HgeneENO1

GO:2001171

positive regulation of ATP biosynthetic process

15459207



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for ENO1-MCUR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ENO1-MCUR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ENO1-MCUR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:8926441/:13788202)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ENO1-MCUR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ENO1-MCUR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ENO1-MCUR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ENO1-MCUR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneENO1C0019193Hepatitis, Toxic2CTD_human
HgeneENO1C0152013Adenocarcinoma of lung (disorder)2CTD_human
HgeneENO1C0860207Drug-Induced Liver Disease2CTD_human
HgeneENO1C1262760Hepatitis, Drug-Induced2CTD_human
HgeneENO1C3658290Drug-Induced Acute Liver Injury2CTD_human
HgeneENO1C4277682Chemical and Drug Induced Liver Injury2CTD_human
HgeneENO1C4279912Chemically-Induced Liver Toxicity2CTD_human
HgeneENO1C0001418Adenocarcinoma1CTD_human
HgeneENO1C0001787Osteoporosis, Age-Related1CTD_human
HgeneENO1C0002395Alzheimer's Disease1CTD_human
HgeneENO1C0003873Rheumatoid Arthritis1CTD_human
HgeneENO1C0006142Malignant neoplasm of breast1CTD_human
HgeneENO1C0007097Carcinoma1CTD_human
HgeneENO1C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneENO1C0007137Squamous cell carcinoma1CTD_human
HgeneENO1C0011265Presenile dementia1CTD_human
HgeneENO1C0014859Esophageal Neoplasms1CTD_human
HgeneENO1C0021364Male infertility1CTD_human
HgeneENO1C0024623Malignant neoplasm of stomach1CTD_human
HgeneENO1C0024667Animal Mammary Neoplasms1CTD_human
HgeneENO1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneENO1C0026640Mouth Neoplasms1CTD_human
HgeneENO1C0027626Neoplasm Invasiveness1CTD_human
HgeneENO1C0029408Degenerative polyarthritis1CTD_human
HgeneENO1C0029456Osteoporosis1CTD_human
HgeneENO1C0029459Osteoporosis, Senile1CTD_human
HgeneENO1C0038356Stomach Neoplasms1CTD_human
HgeneENO1C0086743Osteoarthrosis Deformans1CTD_human
HgeneENO1C0153381Malignant neoplasm of mouth1CTD_human
HgeneENO1C0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneENO1C0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneENO1C0205643Carcinoma, Cribriform1CTD_human
HgeneENO1C0205644Carcinoma, Granular Cell1CTD_human
HgeneENO1C0205645Adenocarcinoma, Tubular1CTD_human
HgeneENO1C0205696Anaplastic carcinoma1CTD_human
HgeneENO1C0205697Carcinoma, Spindle-Cell1CTD_human
HgeneENO1C0205698Undifferentiated carcinoma1CTD_human
HgeneENO1C0205699Carcinomatosis1CTD_human
HgeneENO1C0276496Familial Alzheimer Disease (FAD)1CTD_human
HgeneENO1C0494463Alzheimer Disease, Late Onset1CTD_human
HgeneENO1C0520459Necrotizing Enterocolitis1CTD_human
HgeneENO1C0546126Acute Confusional Senile Dementia1CTD_human
HgeneENO1C0546837Malignant neoplasm of esophagus1CTD_human
HgeneENO1C0678222Breast Carcinoma1CTD_human
HgeneENO1C0750900Alzheimer's Disease, Focal Onset1CTD_human
HgeneENO1C0750901Alzheimer Disease, Early Onset1CTD_human
HgeneENO1C0751406Post-Traumatic Osteoporosis1CTD_human
HgeneENO1C0848676Subfertility, Male1CTD_human
HgeneENO1C0917731Male sterility1CTD_human
HgeneENO1C0948089Acute Coronary Syndrome1CTD_human
HgeneENO1C1257925Mammary Carcinoma, Animal1CTD_human
HgeneENO1C1257931Mammary Neoplasms, Human1CTD_human
HgeneENO1C1458155Mammary Neoplasms1CTD_human
HgeneENO1C1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneENO1C2239176Liver carcinoma1CTD_human
HgeneENO1C4704874Mammary Carcinoma, Human1CTD_human