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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADCK5-INPP5B (FusionGDB2 ID:HG203054TG3633)

Fusion Gene Summary for ADCK5-INPP5B

check button Fusion gene summary
Fusion gene informationFusion gene name: ADCK5-INPP5B
Fusion gene ID: hg203054tg3633
HgeneTgene
Gene symbol

ADCK5

INPP5B

Gene ID

203054

3633

Gene nameaarF domain containing kinase 5inositol polyphosphate-5-phosphatase B
Synonyms-5PTase
Cytomap('ADCK5')('INPP5B')

8q24.3

1p34.3

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized aarF domain-containing protein kinase 5type II inositol 1,4,5-trisphosphate 5-phosphataseinositol polyphosphate-5-phosphatase, 75kDaphosphoinositide 5-phosphatase
Modification date2020031320200313
UniProtAcc

Q3MIX3

.
Ensembl transtripts involved in fusion geneENST00000526231, ENST00000308860, 
ENST00000532190, 
Fusion gene scores* DoF score4 X 2 X 4=3213 X 8 X 4=416
# samples 413
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(13/416*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADCK5 [Title/Abstract] AND INPP5B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADCK5(145603179)-INPP5B(38328102), # samples:2
Anticipated loss of major functional domain due to fusion event.ADCK5-INPP5B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCK5-INPP5B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCK5-INPP5B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCK5-INPP5B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCK5-INPP5B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ADCK5-INPP5B seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ADCK5-INPP5B seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
ADCK5-INPP5B seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ADCK5-INPP5B seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneINPP5B

GO:0046856

phosphatidylinositol dephosphorylation

7721860


check buttonFusion gene breakpoints across ADCK5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across INPP5B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-2398-01AADCK5chr8

145603179

+INPP5Bchr1

38328102

-


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Fusion Gene ORF analysis for ADCK5-INPP5B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000526231ENST00000373023ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
3UTR-3CDSENST00000526231ENST00000373024ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
3UTR-3CDSENST00000526231ENST00000373026ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
3UTR-intronENST00000526231ENST00000373021ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
3UTR-intronENST00000526231ENST00000373027ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
3UTR-intronENST00000526231ENST00000458109ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
3UTR-intronENST00000526231ENST00000467066ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
5CDS-intronENST00000308860ENST00000373021ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
5CDS-intronENST00000308860ENST00000373027ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
5CDS-intronENST00000308860ENST00000458109ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
5CDS-intronENST00000308860ENST00000467066ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
5CDS-intronENST00000532190ENST00000373021ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
5CDS-intronENST00000532190ENST00000373027ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
5CDS-intronENST00000532190ENST00000458109ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
5CDS-intronENST00000532190ENST00000467066ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
Frame-shiftENST00000308860ENST00000373023ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
Frame-shiftENST00000308860ENST00000373024ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
Frame-shiftENST00000532190ENST00000373023ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
Frame-shiftENST00000532190ENST00000373024ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
In-frameENST00000308860ENST00000373026ADCK5chr8

145603179

+INPP5Bchr1

38328102

-
In-frameENST00000532190ENST00000373026ADCK5chr8

145603179

+INPP5Bchr1

38328102

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000308860ADCK5chr8145603179+ENST00000373026INPP5Bchr138328102-5231607827565
ENST00000532190ADCK5chr8145603179+ENST00000373026INPP5Bchr138328102-5141516926665

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000308860ENST00000373026ADCK5chr8145603179+INPP5Bchr138328102-0.78509740.21490261
ENST00000532190ENST00000373026ADCK5chr8145603179+INPP5Bchr138328102-0.80388010.19611989

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Fusion Genomic Features for ADCK5-INPP5B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ADCK5-INPP5B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:145603179/chr1:38328102)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADCK5

Q3MIX3

.
FUNCTION: The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730271618821_993711750.0DomainRho-GAP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCK5chr8:145603179chr1:38328102ENST00000308860+215179_41938581.0DomainNote=Protein kinase
HgeneADCK5chr8:145603179chr1:38328102ENST00000308860+21550_6738581.0TransmembraneHelical
TgeneINPP5Bchr8:145603179chr1:38328102ENST00000373023222422_148955994.0DomainNote=PH
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730232224821_993955994.0DomainRho-GAP
TgeneINPP5Bchr8:145603179chr1:38328102ENST00000373024222422_148875914.0DomainNote=PH
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730242224821_993875914.0DomainRho-GAP
TgeneINPP5Bchr8:145603179chr1:38328102ENST00000373026212322_148955994.0DomainNote=PH
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730262123821_993955994.0DomainRho-GAP
TgeneINPP5Bchr8:145603179chr1:38328102ENST00000373027161822_148711750.0DomainNote=PH
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730232224342_668955994.0Region5-phosphatase
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730232224459_460955994.0RegionNote=Substrate binding
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730232224582_583955994.0RegionNote=Substrate binding
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730232224596_598955994.0RegionNote=Substrate binding
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730232224669_782955994.0RegionASH
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730242224342_668875914.0Region5-phosphatase
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730242224459_460875914.0RegionNote=Substrate binding
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730242224582_583875914.0RegionNote=Substrate binding
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730242224596_598875914.0RegionNote=Substrate binding
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730242224669_782875914.0RegionASH
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730262123342_668955994.0Region5-phosphatase
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730262123459_460955994.0RegionNote=Substrate binding
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730262123582_583955994.0RegionNote=Substrate binding
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730262123596_598955994.0RegionNote=Substrate binding
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730262123669_782955994.0RegionASH
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730271618342_668711750.0Region5-phosphatase
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730271618459_460711750.0RegionNote=Substrate binding
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730271618582_583711750.0RegionNote=Substrate binding
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730271618596_598711750.0RegionNote=Substrate binding
TgeneINPP5Bchr8:145603179chr1:38328102ENST000003730271618669_782711750.0RegionASH


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Fusion Gene Sequence for ADCK5-INPP5B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2202_2202_1_ADCK5-INPP5B_ADCK5_chr8_145603179_ENST00000308860_INPP5B_chr1_38328102_ENST00000373026_length(transcript)=523nt_BP=160nt
GCTAAGCGGCGCCGGGCGGGAGAAGAGCGGAGCAGTGGTCGGAGATGTGGCGACCGGTGCAGCTCTGTCATTTCCACTCTGCTCTGCTGC
ACAGAAGGCAGAAGCCCTGGCCGTCCCCTGCTGTGTTCTTCAGGAGAAACGTCAGGGGCCTTCCTCCAAGCTAGCATATTTGGCAGCTTA
TTGCTTCGAAACCCAGCTGGTCACCAAAAGCTTGATATGACAGAGAAGAAGAAGGCTCAAGAATTTATTCACCAGTTCCTCTGCAACCCA
CTCTGAGCCTCTCTCTCCTCCTATTTTACTTGAGGCTGCCAATTACCAGCCCCACCTGTTTCAGCTCAAGAGATGCCTTAAGATAATTAT
GTGAGGCCACTTGGTAGCAAGAATGGCAGCTATTTCCTGAGCCTAGTACCCCAATTAAGCCCACCATTGGTTAGCACACTCAGCGCTGTG

>2202_2202_1_ADCK5-INPP5B_ADCK5_chr8_145603179_ENST00000308860_INPP5B_chr1_38328102_ENST00000373026_length(amino acids)=65AA_BP=24

--------------------------------------------------------------
>2202_2202_2_ADCK5-INPP5B_ADCK5_chr8_145603179_ENST00000532190_INPP5B_chr1_38328102_ENST00000373026_length(transcript)=514nt_BP=151nt
CGCCGGGCGGGAGAAGAGCGGAGCAGTGGTCGGAGATGTGGCGACCGGTGCAGCTCTGTCATTTCCACTCTGCTCTGCTGCACAGAAGGC
AGAAGCCCTGGCCGTCCCCTGCTGTGTTCTTCAGGAGAAACGTCAGGGGCCTTCCTCCAAGCTAGCATATTTGGCAGCTTATTGCTTCGA
AACCCAGCTGGTCACCAAAAGCTTGATATGACAGAGAAGAAGAAGGCTCAAGAATTTATTCACCAGTTCCTCTGCAACCCACTCTGAGCC
TCTCTCTCCTCCTATTTTACTTGAGGCTGCCAATTACCAGCCCCACCTGTTTCAGCTCAAGAGATGCCTTAAGATAATTATGTGAGGCCA
CTTGGTAGCAAGAATGGCAGCTATTTCCTGAGCCTAGTACCCCAATTAAGCCCACCATTGGTTAGCACACTCAGCGCTGTGAGTCGTGAA

>2202_2202_2_ADCK5-INPP5B_ADCK5_chr8_145603179_ENST00000532190_INPP5B_chr1_38328102_ENST00000373026_length(amino acids)=65AA_BP=24

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ADCK5-INPP5B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADCK5-INPP5B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADCK5-INPP5B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource