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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EP300-TNRC6B (FusionGDB2 ID:HG2033TG23112)

Fusion Gene Summary for EP300-TNRC6B

check button Fusion gene summary
Fusion gene informationFusion gene name: EP300-TNRC6B
Fusion gene ID: hg2033tg23112
HgeneTgene
Gene symbol

EP300

TNRC6B

Gene ID

2033

23112

Gene nameE1A binding protein p300trinucleotide repeat containing adaptor 6B
SynonymsKAT3B|MKHK2|RSTS2|p300-
Cytomap('EP300')('TNRC6B')

22q13.2

22q13.1

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase p300E1A-associated protein p300E1A-binding protein, 300kDhistone butyryltransferase p300histone crotonyltransferase p300p300 HATprotein 2-hydroxyisobutyryltransferase p300protein propionyltransferase p300trinucleotide repeat-containing gene 6B proteintrinucleotide repeat containing 6B
Modification date2020032920200313
UniProtAcc

Q09472

.
Ensembl transtripts involved in fusion geneENST00000263253, ENST00000263253, 
Fusion gene scores* DoF score20 X 17 X 12=408016 X 20 X 6=1920
# samples 2922
** MAII scorelog2(29/4080*10)=-3.81444434684392
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/1920*10)=-3.12553088208386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EP300 [Title/Abstract] AND TNRC6B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEP300(41489102)-TNRC6B(40642019), # samples:2
Anticipated loss of major functional domain due to fusion event.EP300-TNRC6B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EP300-TNRC6B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EP300-TNRC6B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EP300-TNRC6B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EP300-TNRC6B seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
EP300-TNRC6B seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
EP300-TNRC6B seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
EP300-TNRC6B seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
EP300-TNRC6B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
TNRC6B-EP300 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TNRC6B-EP300 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TNRC6B-EP300 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TNRC6B-EP300 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TNRC6B-EP300 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEP300

GO:0000122

negative regulation of transcription by RNA polymerase II

10733570

HgeneEP300

GO:0001666

response to hypoxia

9887100|15261140

HgeneEP300

GO:0006110

regulation of glycolytic process

29775581

HgeneEP300

GO:0006355

regulation of transcription, DNA-templated

15261140

HgeneEP300

GO:0006473

protein acetylation

21030595|24939902

HgeneEP300

GO:0006475

internal protein amino acid acetylation

18722353

HgeneEP300

GO:0010742

macrophage derived foam cell differentiation

26504087

HgeneEP300

GO:0010976

positive regulation of neuron projection development

27256286

HgeneEP300

GO:0016573

histone acetylation

25818647|27256286

HgeneEP300

GO:0018076

N-terminal peptidyl-lysine acetylation

12435739

HgeneEP300

GO:0018393

internal peptidyl-lysine acetylation

17403783

HgeneEP300

GO:0018394

peptidyl-lysine acetylation

23811396|23962722

HgeneEP300

GO:0031333

negative regulation of protein complex assembly

23962722

HgeneEP300

GO:0034644

cellular response to UV

24939902

HgeneEP300

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

17403783

HgeneEP300

GO:0043627

response to estrogen

11581164

HgeneEP300

GO:0043923

positive regulation by host of viral transcription

16687403

HgeneEP300

GO:0043969

histone H2B acetylation

23415232

HgeneEP300

GO:0045721

negative regulation of gluconeogenesis

30193097

HgeneEP300

GO:0045815

positive regulation of gene expression, epigenetic

25818647

HgeneEP300

GO:0045944

positive regulation of transcription by RNA polymerase II

12586840|18722353|23811396

HgeneEP300

GO:0051091

positive regulation of DNA-binding transcription factor activity

10518217|25818647

HgeneEP300

GO:0060765

regulation of androgen receptor signaling pathway

18487222

HgeneEP300

GO:0061921

peptidyl-lysine propionylation

17267393

HgeneEP300

GO:0090043

regulation of tubulin deacetylation

18722353

HgeneEP300

GO:0140066

peptidyl-lysine crotonylation

25818647

HgeneEP300

GO:0140067

peptidyl-lysine butyrylation

17267393|29775581

HgeneEP300

GO:1901224

positive regulation of NIK/NF-kappaB signaling

23811396

HgeneEP300

GO:1905636

positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding

23811396


check buttonFusion gene breakpoints across EP300 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TNRC6B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-7480-01AEP300chr22

41546202

-TNRC6Bchr22

40681649

+
ChimerDB4STADTCGA-CD-A486-01AEP300chr22

41489102

-TNRC6Bchr22

40642019

+
ChimerDB4STADTCGA-CD-A486-01AEP300chr22

41489102

+TNRC6Bchr22

40642019

+
ChimerDB4STADTCGA-CD-A486EP300chr22

41489102

+TNRC6Bchr22

40642018

+


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Fusion Gene ORF analysis for EP300-TNRC6B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000263253ENST00000497559EP300chr22

41546202

-TNRC6Bchr22

40681649

+
5CDS-intronENST00000263253ENST00000497559EP300chr22

41489102

+TNRC6Bchr22

40642019

+
5CDS-intronENST00000263253ENST00000497559EP300chr22

41489102

+TNRC6Bchr22

40642018

+
Frame-shiftENST00000263253ENST00000301923EP300chr22

41489102

+TNRC6Bchr22

40642019

+
Frame-shiftENST00000263253ENST00000301923EP300chr22

41489102

+TNRC6Bchr22

40642018

+
Frame-shiftENST00000263253ENST00000335727EP300chr22

41489102

+TNRC6Bchr22

40642019

+
Frame-shiftENST00000263253ENST00000335727EP300chr22

41489102

+TNRC6Bchr22

40642018

+
Frame-shiftENST00000263253ENST00000402203EP300chr22

41489102

+TNRC6Bchr22

40642019

+
Frame-shiftENST00000263253ENST00000402203EP300chr22

41489102

+TNRC6Bchr22

40642018

+
Frame-shiftENST00000263253ENST00000454349EP300chr22

41489102

+TNRC6Bchr22

40642019

+
Frame-shiftENST00000263253ENST00000454349EP300chr22

41489102

+TNRC6Bchr22

40642018

+
In-frameENST00000263253ENST00000301923EP300chr22

41546202

-TNRC6Bchr22

40681649

+
In-frameENST00000263253ENST00000335727EP300chr22

41546202

-TNRC6Bchr22

40681649

+
In-frameENST00000263253ENST00000402203EP300chr22

41546202

-TNRC6Bchr22

40681649

+
In-frameENST00000263253ENST00000454349EP300chr22

41546202

-TNRC6Bchr22

40681649

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263253EP300chr2241546202-ENST00000301923TNRC6Bchr2240681649+185224036121959551578
ENST00000263253EP300chr2241546202-ENST00000402203TNRC6Bchr2240681649+60754036121959551578
ENST00000263253EP300chr2241546202-ENST00000454349TNRC6Bchr2240681649+185224036121959551578
ENST00000263253EP300chr2241546202-ENST00000335727TNRC6Bchr2240681649+185234036121959551578

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263253ENST00000301923EP300chr2241546202-TNRC6Bchr2240681649+0.001093930.998906
ENST00000263253ENST00000402203EP300chr2241546202-TNRC6Bchr2240681649+0.0106546320.9893454
ENST00000263253ENST00000454349EP300chr2241546202-TNRC6Bchr2240681649+0.001093930.998906
ENST00000263253ENST00000335727EP300chr2241546202-TNRC6Bchr2240681649+0.0010963210.99890363

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Fusion Genomic Features for EP300-TNRC6B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EP300chr2241489102+TNRC6Bchr2240642018+7.40E-080.9999999
EP300chr2241489102+TNRC6Bchr2240642018+7.40E-080.9999999
EP300chr2241489102+TNRC6Bchr2240642018+7.40E-080.9999999
EP300chr2241489102+TNRC6Bchr2240642018+7.40E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EP300-TNRC6B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:41489102/chr22:40642019)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EP300

Q09472

.
FUNCTION: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac) (PubMed:23911289). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1 or SIRT2 (PubMed:12929931, PubMed:16762839, PubMed:18722353). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-1431797_8009392415.0Compositional biasNote=Poly-Ser
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-1431566_6459392415.0DomainKIX
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-143111_179392415.0MotifNuclear localization signal
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-1431331_4179392415.0Zinc fingerTAZ-type 1
TgeneTNRC6Bchr22:41546202chr22:40681649ENST0000030192311241150_12203901030.0Compositional biasNote=Gln-rich
TgeneTNRC6Bchr22:41546202chr22:40681649ENST000003019231124825_8803901030.0Compositional biasNote=Pro-rich
TgeneTNRC6Bchr22:41546202chr22:40681649ENST000003357278211150_122010841724.0Compositional biasNote=Gln-rich
TgeneTNRC6Bchr22:41546202chr22:40681649ENST0000040220311241150_12203901030.0Compositional biasNote=Gln-rich
TgeneTNRC6Bchr22:41546202chr22:40681649ENST000004022031124825_8803901030.0Compositional biasNote=Pro-rich
TgeneTNRC6Bchr22:41546202chr22:40681649ENST0000030192311241648_17203901030.0DomainNote=RRM
TgeneTNRC6Bchr22:41546202chr22:40681649ENST000003357278211648_172010841724.0DomainNote=RRM
TgeneTNRC6Bchr22:41546202chr22:40681649ENST0000040220311241648_17203901030.0DomainNote=RRM
TgeneTNRC6Bchr22:41546202chr22:40681649ENST0000045434910231648_172011941834.0DomainNote=RRM
TgeneTNRC6Bchr22:41546202chr22:40681649ENST0000030192311241472_14903901030.0RegionNote=PABPC1-interacting motif-2 (PAM2)
TgeneTNRC6Bchr22:41546202chr22:40681649ENST000003357278211472_149010841724.0RegionNote=PABPC1-interacting motif-2 (PAM2)
TgeneTNRC6Bchr22:41546202chr22:40681649ENST0000040220311241472_14903901030.0RegionNote=PABPC1-interacting motif-2 (PAM2)
TgeneTNRC6Bchr22:41546202chr22:40681649ENST0000045434910231472_149011941834.0RegionNote=PABPC1-interacting motif-2 (PAM2)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-14311519_15269392415.0Compositional biasNote=Poly-Glu
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-14312066_20699392415.0Compositional biasNote=Poly-Gln
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-14312190_21959392415.0Compositional biasNote=Poly-Gln
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-14311067_11399392415.0DomainBromo
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-14311287_16639392415.0DomainCBP/p300-type HAT
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-14311017_10299392415.0RegionNote=CRD1%3B mediates transcriptional repression
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-14311398_14009392415.0RegionAcetyl-CoA binding
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-14311410_14119392415.0RegionAcetyl-CoA binding
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-14311572_18189392415.0RegionNote=Binding region for E1A adenovirus
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-14311664_17079392415.0Zinc fingerZZ-type
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-14311728_18099392415.0Zinc fingerTAZ-type 2
TgeneTNRC6Bchr22:41546202chr22:40681649ENST0000030192311241_393901030.0Coiled coilOntology_term=ECO:0000255
TgeneTNRC6Bchr22:41546202chr22:40681649ENST000003357278211_3910841724.0Coiled coilOntology_term=ECO:0000255
TgeneTNRC6Bchr22:41546202chr22:40681649ENST0000040220311241_393901030.0Coiled coilOntology_term=ECO:0000255
TgeneTNRC6Bchr22:41546202chr22:40681649ENST0000045434910231_3911941834.0Coiled coilOntology_term=ECO:0000255
TgeneTNRC6Bchr22:41546202chr22:40681649ENST00000335727821825_88010841724.0Compositional biasNote=Pro-rich
TgeneTNRC6Bchr22:41546202chr22:40681649ENST0000045434910231150_122011941834.0Compositional biasNote=Gln-rich
TgeneTNRC6Bchr22:41546202chr22:40681649ENST000004543491023825_88011941834.0Compositional biasNote=Pro-rich


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Fusion Gene Sequence for EP300-TNRC6B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>26760_26760_1_EP300-TNRC6B_EP300_chr22_41546202_ENST00000263253_TNRC6B_chr22_40681649_ENST00000301923_length(transcript)=18522nt_BP=4036nt
CTTGTTTGTGTGCTAGGCTGGGGGGGAGAGAGGGCGAGAGAGAGCGGGCGAGAGTGGGCAAGCAGGACGCCGGGCTGAGTGCTAACTGCG
GGAGCCAGAGAGTGCGGAGGGGAGTCGGGTCGGAGAGAGGCGGCAGGGGCCGAGACAGTGGCAGGGGGCCCGGGGCGCACGGGCTGAGGC
GACCCCCAGCCCCCTCCCGTCCGCACACACCCCCACCGCGGTCCAGCAGCCGGGCCGGCGTCGACGCCTAGGGGGGACCATTACATAACC
CCGCGCCCCGCGGCGTCTTCTCCCGCCGCCGCGGGCGGCCCCGAACGGAGCCCCGGGGGGCGGGCGCTCCCAGCACCTGGCCGCCGGCGG
TGGGGGCCGTAGCAGCGGCCGTATTTATTTATTTTCCGCGGGAAAGGAAGGCGAAGGAGGGGAGCGCGGCGCGAGGAGGGGCCGCCTGCG
CCGCCGCCGGAGCGGGGCCTCCTCGGTGGGCTCCGCGTCGGCGCGGGCGTGCGGGCGGCGCTGCTCGGCCCGGCCCCCTCGGCCCTCTGG
TCCGGCCAGCTCCGCTCCCGGCGTCCTTGCCGCGCCTCCGCCGGCCGCCGCGCGATGTGAGGCGGCGGCGCCAGCCTGGCTCTCGGCTCG
GGCGAGTTCTCTGCGGCCATTAGGGGCCGGTGCGGCGGCGGCGGCGCGGAGCGCGGCGGCAGGAGGAGGGTTCGGAGGGTGGGGGCGCAG
GCCCGGGAGGGGGCACCGGGAGGAGGTGAGTGTCTCTTGTCGCCTCCTCCTCTCCCCCCTTTTCGCCCCCGCCTCCTTGTGGCGATGAGA
AGGAGGAGGACAGCGCCGAGGAGGAAGAGGTTGATGGCGGCGGCGGAGCTCCGAGAGACCTCGGCTGGGCAGGGGCCGGCCGTGGCGGGC
CGGGGACTGCGCCTCTAGAGCCGCGAGTTCTCGGGAATTCGCCGCAGCGGACGCGCTCGGCGAATTTGTGCTCTTGTGCCCTCCTCCGGG
CTTGGGCCCAGGCCCGGCCCCTCGCACTTGCCCTTACCTTTTCTATCGAGTCCGCATCCCTCTCCAGCCACTGCGACCCGGCGAAGAGAA
AAAGGAACTTCCCCCACCCCCTCGGGTGCCGTCGGAGCCCCCCAGCCCACCCCTGGGTGCGGCGCGGGGACCCCGGGCCGAAGAAGAGAT
TTCCTGAGGATTCTGGTTTTCCTCGCTTGTATCTCCGAAAGAATTAAAAATGGCCGAGAATGTGGTGGAACCGGGGCCGCCTTCAGCCAA
GCGGCCTAAACTCTCATCTCCGGCCCTCTCGGCGTCCGCCAGCGATGGCACAGATTTTGGCTCTCTATTTGACTTGGAGCACGACTTACC
AGATGAATTAATCAACTCTACAGAATTGGGACTAACCAATGGTGGTGATATTAATCAGCTTCAGACAAGTCTTGGCATGGTACAAGATGC
AGCTTCTAAACATAAACAGCTGTCAGAATTGCTGCGATCTGGTAGTTCCCCTAACCTCAATATGGGAGTTGGTGGCCCAGGTCAAGTCAT
GGCCAGCCAGGCCCAACAGAGCAGTCCTGGATTAGGTTTGATAAATAGCATGGTCAAAAGCCCAATGACACAGGCAGGCTTGACTTCTCC
CAACATGGGGATGGGCACTAGTGGACCAAATCAGGGTCCTACGCAGTCAACAGGTATGATGAACAGTCCAGTAAATCAGCCTGCCATGGG
AATGAACACAGGGATGAATGCGGGCATGAATCCTGGAATGTTGGCTGCAGGCAATGGACAAGGGATAATGCCTAATCAAGTCATGAACGG
TTCAATTGGAGCAGGCCGAGGGCGACAGAATATGCAGTACCCAAACCCAGGCATGGGAAGTGCTGGCAACTTACTGACTGAGCCTCTTCA
GCAGGGCTCTCCCCAGATGGGAGGACAAACAGGATTGAGAGGCCCCCAGCCTCTTAAGATGGGAATGATGAACAACCCCAATCCTTATGG
TTCACCATATACTCAGAATCCTGGACAGCAGATTGGAGCCAGTGGCCTTGGTCTCCAGATTCAGACAAAAACTGTACTATCAAATAACTT
ATCTCCATTTGCTATGGACAAAAAGGCAGTTCCTGGTGGAGGAATGCCCAACATGGGTCAACAGCCAGCCCCGCAGGTCCAGCAGCCAGG
CCTGGTGACTCCAGTTGCCCAAGGGATGGGTTCTGGAGCACATACAGCTGATCCAGAGAAGCGCAAGCTCATCCAGCAGCAGCTTGTTCT
CCTTTTGCATGCTCACAAGTGCCAGCGCCGGGAACAGGCCAATGGGGAAGTGAGGCAGTGCAACCTTCCCCACTGTCGCACAATGAAGAA
TGTCCTAAACCACATGACACACTGCCAGTCAGGCAAGTCTTGCCAAGTGGCACACTGTGCATCTTCTCGACAAATCATTTCACACTGGAA
GAATTGTACAAGACATGATTGTCCTGTGTGTCTCCCCCTCAAAAATGCTGGTGATAAGAGAAATCAACAGCCAATTTTGACTGGAGCACC
CGTTGGACTTGGAAATCCTAGCTCTCTAGGGGTGGGTCAACAGTCTGCCCCCAACCTAAGCACTGTTAGTCAGATTGATCCCAGCTCCAT
AGAAAGAGCCTATGCAGCTCTTGGACTACCCTATCAAGTAAATCAGATGCCGACACAACCCCAGGTGCAAGCAAAGAACCAGCAGAATCA
GCAGCCTGGGCAGTCTCCCCAAGGCATGCGGCCCATGAGCAACATGAGTGCTAGTCCTATGGGAGTAAATGGAGGTGTAGGAGTTCAAAC
GCCGAGTCTTCTTTCTGACTCAATGTTGCATTCAGCCATAAATTCTCAAAACCCAATGATGAGTGAAAATGCCAGTGTGCCCTCCCTGGG
TCCTATGCCAACAGCAGCTCAACCATCCACTACTGGAATTCGGAAACAGTGGCACGAAGATATTACTCAGGATCTTCGAAATCATCTTGT
TCACAAACTCGTCCAAGCCATATTTCCTACGCCGGATCCTGCTGCTTTAAAAGACAGACGGATGGAAAACCTAGTTGCATATGCTCGGAA
AGTTGAAGGGGACATGTATGAATCTGCAAACAATCGAGCGGAATACTACCACCTTCTAGCTGAGAAAATCTATAAGATCCAGAAAGAACT
AGAAGAAAAACGAAGGACCAGACTACAGAAGCAGAACATGCTACCAAATGCTGCAGGCATGGTTCCAGTTTCCATGAATCCAGGGCCTAA
CATGGGACAGCCGCAACCAGGAATGACTTCTAATGGCCCTCTACCTGACCCAAGTATGATCCGTGGCAGTGTGCCAAACCAGATGATGCC
TCGAATAACTCCACAATCTGGTTTGAATCAATTTGGCCAGATGAGCATGGCCCAGCCCCCTATTGTACCCCGGCAAACCCCTCCTCTTCA
GCACCATGGACAGTTGGCTCAACCTGGAGCTCTCAACCCGCCTATGGGCTATGGGCCTCGTATGCAACAGCCTTCCAACCAGGGCCAGTT
CCTTCCTCAGACTCAGTTCCCATCACAGGGAATGAATGTAACAAATATCCCTTTGGCTCCGTCCAGCGGTCAAGCTCCAGTGTCTCAAGC
ACAAATGTCTAGTTCTTCCTGCCCGGTGAACTCTCCTATAATGCCTCCAGGGTCTCAGGGGAGCCACATTCACTGTCCCCAGCTTCCTCA
ACCAGCTCTTCATCAGAATTCACCCTCGCCTGTACCTAGTCGTACCCCCACCCCTCACCATACTCCCCCAAGCATAGGGGCTCAGCAGCC
ACCAGCAACAACAATTCCAGCCCCTGTTCCTACACCTCCTGCCATGCCACCTGGGCCACAGTCCCAGGCTCTACATCCCCCTCCAAGGCA
GACACCTACACCACCAACAACACAACTTCCCCAACAAGTGCAGCCTTCACTTCCTGCTGCACCTTCTGCTGACCAGCCCCAGCAGCAGCC
TCGCTCACAGCAGAGCACAGCAGCGTCTGTTCCTACCCCAACAGCACCGCTGCTTCCTCCGCAGCCTGCAACTCCAGGCGGTAGTCATGG
TTTGTTTGGAAACAGCACAGCACAATCGAGAGGTCTGCACACACCCGTGCAGCCACTAAATTCTTCTCCCAGTCTCCGGGCGCAAGTGCC
TCCCCAGTTTATTTCCCCCCAGGTTTCTGCCTCAATGCTCAAGCAGTTTCCCAACAGTGGCCTGAGTCCAGGTCTTTTCAATGTGGGGCC
CCAGTTATCTCCTCAACAAATTGCCATGCTGAGCCAGCTTCCACAAATTCCCCAGTTTCAGTTGGCATGTCAGCTTCTCTTGCAGCAGCA
GCAACAGCAGCAGTTGTTACAGAACCAGAGAAAGATTTCTCAAGCTGTACGCCAACAGCAAGAGCAGCAGCTGGCTCGAATGGTGAGTGC
ACTGCAGCAGCAGCAGCAGCAGCAGCAGAGGCAGCCAGGCATGAAGCACTCGCCCTCTCATCCTGTTGGGCCCAAGCCGCATCTGGACAA
CATGGTACCCAACGCATTGAATGTGGGGCTCCCAGACCTTCAAACCAAAGGGCCAATACCTGGATATGGTTCTGGCTTCAGCTCTGGCGG
CATGGACTATGGCATGGTTGGTGGGAAGGAGGCTGGAACCGAGTCTCGCTTTAAACAGTGGACCTCCATGATGGAGGGGCTGCCCTCTGT
AGCCACACAGGAAGCCAATATGCACAAAAATGGCGCTATAGTGGCCCCTGGTAAAACCCGGGGAGGGTCACCGTACAACCAGTTTGATAT
CATCCCTGGTGACACACTGGGTGGCCATACGGGTCCTGCTGGTGATAGCTGGTTACCTGCCAAATCTCCACCAACAAATAAAATCGGAAG
TAAATCCAGCAATGCCAGTTGGCCTCCAGAATTCCAACCAGGAGTGCCATGGAAAGGTATCCAAAACATTGACCCTGAATCTGACCCCTA
TGTCACCCCAGGAAGTGTGCTGGGGGGTACAGCCACATCTCCCATTGTAGATACTGACCACCAACTGCTGCGGGATAACACCACAGGGTC
TAATTCTTCCCTCAACACCTCGCTGCCTTCACCTGGTGCCTGGCCCTACAGTGCCTCTGACAACTCCTTTACCAACGTTCATAGCACTTC
AGCAAAGTTCCCTGATTACAAATCAACATGGTCCCCAGATCCCATAGGACACAACCCCACTCATCTCTCCAACAAGATGTGGAAAAACCA
TATTTCCTCCAGGAACACTACACCGCTGCCCCGCCCACCTCCTGGTCTGACCAACCCCAAACCATCATCTCCCTGGAGCAGCACAGCACC
CCGATCAGTCAGGGGGTGGGGGACACAGGACTCACGGCTCGCCTCGGCCTCTACCTGGAGTGATGGTGGCTCAGTTCGTCCTAGTTACTG
GCTGGTTCTTCACAATCTCACCCCACAGATTGATGGGTCAACCTTGAGAACGATCTGCATGCAGCATGGCCCACTGCTGACATTCCATCT
GAATCTAACCCAGGGCACTGCCCTGATCCGATACAGCACCAAACAGGAGGCGGCCAAGGCCCAAACTGCACTGCACATGTGTGTGTTGGG
AAACACTACCATCCTTGCTGAGTTTGCCACTGATGATGAAGTCAGCCGCTTTCTGGCACAAGCTCAGCCCCCTACACCTGCAGCAACCCC
AAGTGCGCCAGCTGCGGGGTGGCAGTCGCTGGAGACCGGCCAGAACCAGTCAGATCCCGTGGGACCTGCTCTGAATCTTTTTGGTGGGTC
CACTGGGCTCGGGCAGTGGAGCAGCAGCGCTGGTGGCAGCAGCGGGGCCGATCTTGCTGGCGCTTCATTGTGGGGGCCCCCAAACTATTC
TTCTAGCTTATGGGGAGTCCCAACGGTGGAAGATCCCCATAGGATGGGCAGCCCTGCTCCTTTACTACCTGGTGACCTTCTGGGAGGAGG
GTCGGATTCAATCTGAACTTAGAACTTTCAACTCTGACCTCGTGACCTTTTTTGGAACAGCAGCAGCACTAACTTGACCTTTTCGTTTTT
TTTTTCAACTTGCAATAAATACATTTTTAAAAGGAAAAAAGAAAACGGAGAGAAAAAAAGGTGGGTCATTGACAGACTGTCTGAGCACAT
AGTTGCCTCCCTTATAACTTCAGTTTTTTCGTTTGGAATATGAATCCAAAAAGAGAACATATCACTCTTGAAATACTTGAATCATGAACG
CCAACCTAGAAAGACAATGTGAAGCAAGTACACATACCATTTAAATTTAAACACAAAAAAATTAAAAAAATTAGTTTCTAGTTTTTCACT
TTTTTCATGTTATATGGAAGTTGTTGCTAAGAAACATATATACTGAAAAAAAATAGCTTTTTAACTTTGTTTGCACTGGGTGTGTTTCCG
TCCTTAGGTCTACCATGTTTGGGAGGGAGGGAAATTCAAAAGAATTGTTGGGGGAGGGGGGAGGGAAGACTTGACGGAGCCTCACTTTAA
AAACAAAAACACAAAAAACCTAAAAAAAAAAAAAAGGAAAAAATTTGTGATTGGCTGGTTGATAAATACCAGTGTGTTCTGGCACATGTA
ACTGCCCAGGCATGCTCGTTCTGGTGTGTGTGTGCACGTGTGTTCATGTGCATTCGCGTGCATCCTTCTCTGTCTCTGTGTGTGTGCCTG
TGTTCTTCCCTTCTCCCCTGCCCCACCCTGACTTCTCAGAAAGCTGCATCGCTGACAGTCTGCAGGCTGGCTGGCCGGCCCATCTGCTTT
TTATTTTATTTTTTTAACTATGAGAACACACAGGCCCGGAGAGCCACTGCTACTAAAGCAACTCCATTGGGCTGCATTAAGATGAACAGA
GTGCTTTTTAATGATGAAAGCAGGGAGCTCCTTTCCATTTGCAACTTAGCCTGAATGTGGGGTTTCTCTGGCTGTTCTTTTGACCTAGCA
GTAGAGTGGAGCACTGCCAAGTCCAAAAAACTAGAGCAGGAGGTACCTCTTGGAGCAACGGTGTGTTTATTTCTGTTTTTTTTTTTTTTT
AAGTGAATGGCCACCAGGCACATCTGAGTATCTGTTAAGTTTCATGCAGGCCTTTTCGTTAGTTTGAAATGGGAACGGAAGATAACTTTT
GATGATGCGATGTCTCAAAAACAGAGAAACTTTGTTCCCTCTTTCCTTATGATCAGGTTTGAGAAATTCTTCAAAAAATTAGGTGAAGTT
GAGTTACATATTTCTGTTGGTTGGTTCTCTTTTTCATTTTATGAAAACAGAAAAGAATAAGTGGTGAGCAGCCTCCTGAAAGCATCTGCA
GCTACTCCCTCTGCTCCTTTCTCGCCGAGCGTTACCTGTGCCAGGCCGTGGCGCGTTACAGCACCAGGCCATCACTGACAGAAACGTTTA
CTTAACGAATGTTCTTAAACCAGTGTGTACTTCAAGCGTTTCCTTTTGTTTCTCTGTGTTGTGTATTTCCTGTGTATGTGGTTTTGCTTA
GGCAGGTATAACTTAGCGAAGACTTTTAAGTATTGCACCTTTTTTTGATTTTTGACCTCTTCCCCCCACCTTGTAATTTTGCTTTTTTAA
TTTCGGTATTTAAATACTTTTTTTTTTTTTTAAGCATCAATGTAGTAGTACTCTGGGCCGAACAGGGGTCAACGTTTAATCTACAGTTAT
CACCAACATGTATGTACTTATGTCGGAATCAAAATGTATCAAACTGCTTATTGTGAAGAGAATTATAGCAGACCTGAAGGGGGCGAAAAA
CCAGATAGGGTGGGGGGATGGATGCCGGTGACGTGCTAGCACTTGTGTGGACATCCCAGTCTGCATTATGCTGTTTAACATAAAGTGCCG
ACATTTTGTACCAGCAAATACCTGCCCATTCCAACCCTTGGTGGGAGCAGACCTCTACTGTCCTCTGTAACTTGCTGCTATTGAGGACAA
GGGAGTTTTTCTTTCTTTAGCGTCTTCAGTGAAGGATACAATACAACAATGCCTAATGTATTTGACTTTTTAGCTTGTGTCTGTGTGTAG
GTGGGTGGGTGGGTGTGTATAGGAAAAGCCTAAAACAAGTTATTTGCATTTCAGTGGTTTTGTGAGACAAAGAATGGGAAATTCTGTAGC
CCTTCTGGCTTACCCTGTTGATTATAAACCTAGCCTCAAAAGAGATTGACAGGCATGACTCAAGTGAGTGTTCACATATACAAGCCTGCA
TGAGCCCTCTGTGGGTAGGTGGTCACACTTGGCATCTGCAGCATTGACGTGGCCCCGCTGGGTGCCTTGAGCATGCCCTCTTCCTGCTCT
GCAATTTGAATCACCACCGTGCCCCTTCCACCACTGTTCCCCATGCAAAAGCTCTGCTTCCAGCAGCCCCCACTGACCGCTCTCTGTGTG
GAGCAAAGTGCTGTCGTGCGGTGACCACCAGGTGAAGAGCAGCTTGTATTCAGACATCTAGAGAAGGTTAAATCTTAGTGTCCCTGGGCC
AGGAGCATATCCCAAGGCTCCTGCGAGCCAGTGGCGACCCTGTCCACTGCCGCTCTTGGTTCACTGCTGTGTCCTGCCCCACCCTCCTCT
CCTCCTGCCTGTTGGTTCCTTGACCTGCACTATGGGTTAGTTGAGTTCCTTACGATACTACGGTGAAAGCCGGGTGCTAGAGCCCCTCTT
GTTTACAAGACATAATGAGGGATTTGAAATATGTAAAAATAAACATGAGAAGCTAAAATGTTCTTCCATCATAAGCTTAAAGGGAAAAAA
ACTAAAAACTTTAAAAAAAAAAGACCAAAAAGTGCGTATATATATACATATAAATATATATTTTAGATGAAGACTAACTCTGGGAGCATT
TAACAGTGTTTTTTGTTTCTGTTTTTAACATTTGTTTTCCTGCTTTAAAATTTGCAAGCATTCTCAGGAATTCTAGGGTAGGAAGCCAGT
TTTTTGAAGATGGTTTATTTAACCATATCTTATCCTAGAGAGATGGCTGTTTCTTTCCTGTTAATAAACTTTTACAAGTTCCTGAAACTT
CAGAAAGTTTAAACAATTTTTACTTAAAAAAATGTAAAAAGAAAAGTCTCCAAACATTATTGTCATACTGGGGATCACACATTTTAAAAC
ACATAGAAATATTTTTTAAAAATTATCAATTTAGCAGCAACAGGTAAATTCATTATCTTAAAAATATGGGAGAAGGATTAAGCTTTGTAA
GAGCTCGATCATGGATTCTTTTGAAATTGTGTGTAGTTTAATGGGAGAGTGTTTGGTGTATATAGATGAGAATGCCATCACTTTGTTCCT
TTCCATTTGAGACTGAACTGAAATCTCCCCTAGTAATTTTTATTTTTTTAAAGGAACCCTTCTCCTTGTCCCCACAACCCCAGCAACAAA
AGAAAGGAAGGAAGGAAGAAACAACAGCTTAAAAAAAAAAGTAATCTGTAAAATAGTACAGTTGGATTGCTGAGAATCTATGTAAAGAGT
TAGGAAATATAGGTTAATAATTTTTGGAACAAATTTTAAATATAGGCATTACTAGAGGAAAATTATCTATGGACTGTCCTATTAATGAAG
AATGTCTGTCTTACCTCCGTTTGTTTTGGGAGGAGGAGAAAATATAGAAGAATCTAATAAGGAACAAGTGATTTTACTTTTTTAGCTCCC
AGCTACTGTTGTGCTCGTTTTAATTGCTGTTTTGAAGATCTGCTGCTTAATTATCCCCATCCCTTAGCCGGAGATGTGGAGTGTTTCCTT
TCAGTTTTTGGTGATGTTGAATTCTTTTGTATTCCCTCCTGGGGCCAGGGGTCAGAATTCCCAAGCATGACCACAGCTTCTTTTAAACAT
TAAGCTTCCCAGTGGGAAGGAAACTCCAGCTCGACAGGTAAAGGGAGTGGGTGGGGTTGCTGCCTGCAATTTCTCTAAAACCGCTTTAGT
GCCTTCGTACATACACCCAGACATCCTGAGCAAGGGGGACGCACATGTGTGTGTGTGTGGTCCAGTCACTCCACAGATGTAAGATACTCA
CCCATAAAGGAAATTGGAGTGGTTCTGGACAGGCCCCAAAGGCAGTGGGCTGAATTTAAAATAAATAAACAAACGTCAAGCAAGTTAATA
TGCTTATGTCTCAGTAATGTAGAATGCCAAGTTCCTTCCTGTGTCGTGTGCCCTCCATTACTGTGCATTGATTCCTCCAGGTGTGTAATT
GTGACAACTGCAGTGATTTGGAAAGTCTCTTTGTCTTGGGCAAATAGAAGGGGTTCCTGTTGTTCTGCTCTTGTCCTTCGTCTCCTCCCC
TTTTCCCCCAGACCTCCCCCTTCTTTTTGTCAACTTGCTGGGAGCTTTGCTTTATTGGTTGGCAGTGACCTAAGAACAGGATATGGTGAG
GATGTCATGGAAGAGAAGAGCTCTTTCCGTGGTATTCTTTGGCAAGAGCCATGTCTACTAAGAGGTTAGATGACTTCAGTATACTTATAA
AATTCAGTGAGAGTGCCTTCTTCTCTTCTACCACACTCTGGCATAGATACAGGCTTGCTGGTCACCTCTCATTACATAGATTTATTTTAA
AAACATTTTGATTATGTTAATTTGAGCTTTCCCTTTTTTTTTTTTAACTACTTTTTAAAACACTTGATTACTAGTGGCTTAGAGGTGTGT
ACATCTCCTGAACATCACAAACTTGGTTTCTACCTACCACACGAGTAGCCAAAAGAAAAGAAGCACTAATAGAGAAAGGGGTGTCTCACA
CCAGACAGAGGACCTCTGCTGTCAATTAGATCCAGTATCATGACCTAACTTTAAGTGTGGAAAAGAGTTCAGATCTCTGAGACACTGTGA
AGAAATGGATGGCTCATGTAACATCTCTGATCCCTCAGTCCCCAACCCTGGACGTGTTTCATTTACAACATTCATAGGAGTTAACTTAGC
AGTGTTGCAAGTTAAGGTTCCAAACCAAATTATTTAATCAGTGTCCCCCCAATAAATCACTTATCCATTTATTGCTAGTTAGTTTTATTT
ATAGCAACTTGATTTCCTATGAGTATGGCTCCTGTTGTAAGAATTTTCCCACCTCTTCTGACATGAATGTAGCATAAGTTAGCAATCGGT
TCTTCCAAACTCCTGTGGGTTGAATATGGTATAGAAGGTATGCAAGAGGAAAAAGAAAGGAAAAGATAAAACTCCTGCCTGAGAATTTGG
AAGCACCTTTATTAACACATATATCTCGCAGAAACTAGAAGCTCATAGGCTGTTAACTTTTTGCAACTATTCACTCATTTTTACCACTTT
TTTTTTTGGGTGAGGGGGTGATTTTTGTAAGGTTAACAGCCAGATTCCATTTTGACCTCAGATGCTGTGTACTTTTTAATTTCATTTTTT
ATATTCTGCCATCTTGACTCTTCTCTAAAACAGAATGAAAATGTCTGCATGCTGAGCAAAATGCTTACGCCAAGCCTGTTTTTCTCTGCA
GAGTAAACAGGATGTTTTCAGCAGACTTGGCTCTAATAGCCATCTCTAAGATTAGGGAACAATTGAGTCTTTATGTAGAAAAGATCCATT
TTTTCCCCATCCTCAGAGTTAAAATTCAACATTTAAAGCTTTATCGGTTATTGTTTTAGATTTGAGATTTTTGTTTTTAAGTATCTATAA
GATCTTTAGAAGTGAGATAAATTTTTCGCTGGTTAAAAAAAATCAAACTTTCCTCTGCAGTGTTTTTGCCAAGTTTTGTCACACTTCATG
TGTATGCATTAACTATACTTCTTAGTGTTACTGCAAAAAAAAAAAACAAAAACAAAACAAAAAAAAGCCTTGTTCTTTAATTGTGTTTTT
CCTCCTGTGAGTGGACAACTAAAGCCGCGTGATGATGCGGATGAAAATATTCTGGTCTGTGTGTATACAATGAATTGTCAGTCTTCAGAC
CTCATGGTCGTTAAGAAAATAGGGAACTCACAAACCCTGCTGCGCACTACATTTACTTCTTTATCTGCAAGTACAGGGAGTCCATACAGT
CAAGAAACACACAGATACACATAATGCTATTGAGGACATTGTCATTCTGTAAGAAAACAGAATATTATCTAGATTTCCAGAGTTAGTGCA
GACCCTGTGATAACAGTCTGTGGGTTTGTGGCCAGCGCCAAAGGTGTGTGTATTTTCAGAAATGGTCCCTATTTGTCAGTGATAGTGTTT
TTTTTTTCTTAAGTTTGACAAAGGGGGTGGTAATATCACATTCTTTAGATTTGAAATAATTATCAGCTCCAAGAATCTGTGAACATAGTA
ATAACAATAAAAATTCAACATCGACCCTCCCTAACCTGCTCACCATACCTCCCCACCCCATGCCTCTGAAGAAAGAGGCCATGAACCTAC
GAGGTGGTAAAGGGGGACACAGGTCAGGGAGTGGAGAGCTACTCCTCCAGCAGCTCAGCACCCACACTGCCCGCATGCGTGTGGCCACCG
GGACCAGATCCCGAGTGATTGTGGCATACCCCTAATATTTGAGTAGTTTTTAAGCTGTCAGTCTCTTGTCATAACCTCCTACCGCCACCC
AAAAAAGTAACGAAAGTTGCAGTAACTGCCAGTGTTTGCCTCACCAAATTTAAATCGTTCCCTTTTCAGTTAGCTATATACCTGAATTTG
TTTTTAACAAGAAACTGTACATGGCCAGGAAAAATGGTACTACCTTGGCCAAAGGGTCTTTGCAAAAAGCTCAGTCTTCAGTTCTTCACT
GTGACAAATGCTTATCTTGTTCATGGGAGGGGAAAGATCAGATAAATAGGCAAGAAGTACTCTGTTTTAAATAAAGAATAAATAGTGTCC
GTTTAAAGCACTTTGTGCCTCAACTTCATTTTTAAACTGTAAATCATTGCTTTGGAAATAAATTCCCAATTATAATTGACCCATATCTAG
CCAATATCAACAAGTTGGGATGGTTTTTGTTTTTTTCTTTTTTTTCAAAAAGGGAAATTCCTCTTTACTGCTCACAGTAAGCTGCAAAAG
AAAGTTGTCAAGGTGGCTTATGATGCTGTTGTAGCAGAGCTGTGAAAGGAAGTGCTTTGCTTTCTCTCCCGCCTTCCGGAATCTGGCGTT
CCTTCCCCTTCGGCTACTGAAAGGTGTGTACAACTCCCAGAGGGGTGGCTGTAAAAGTTGACTGGAGGCAAAGTGGAGTGGCCTTATTGC
CAGGACTAGCCCTACAGAAGAGCTTTACAGAGAGGAGGACAGTACATCCTATGTGTGTTCGCCAAAAATGGGAAAGGTGGGTATTTAGGC
AAAACAAAATAAAAACCTTTGGAACCCTTTAAGAAGTTACATACCTTTTAAAGGTAGTATAGTTTCTCACCAAGTGATGCATTTTAGCAT
GACACTTCTTGCCAGAAATTTTGGGATAAGTTGGAATAAATGTGTTTAAAACATCATCCACCGCCCTTTTTAAATTTTGTCTAAGGAATT
ACTTAAGTATAGTATTTCTGAATGTGCCTTTGTGAGTACAGAGACCGTCCGTTCTAGGAAGAAGCTATCCGTTGGATACAAACAAACAGA
CGGTCAGCTTTAGTCATTAGGGAAGTCAAAGTTCCTCCTGGAAGTCCCAGGAGCAGCTGTTGAGATTTCATTAGCATCAATATTGCACAG
TGTAGAGTTGAGTGGAAGAGATTCTGGGACTTGGGAGAGGAGACAGGGGAAGGTACCCAGGCGACGCAGACCCACGTTAGTCCAAGAGCG
CAGGTTTACACATCTGCATTCCCTAGTTTTCTCCGTCTGTATGTTTGTGCTCATGTGGCTTTGGCTGTTTTGTTTTTTGTTTTTCTGTAA
GCACTGGAGAATTGGAATATGGTGATACTTGTGACACATTCATGCATGTAAACAAGGCATTTTCCAGCTTCTGCCGTGTGCAGAGCGGGC
AGCACGCTTTTACCCTTTGAGTCTGTGTCCTGAGGCGGCCATTACATTCCCACATGGGCGTCACATCACGTTGCTGTTGATGCAAACAGG
GTATTACACACAAGGAAAAGGGGTTTTGAAGAGTTAAGATTGAAGTGTTTGAGAAAGAAAAGAGAAAAATCTGAAATCATATTTTATTTC
TTCAGAGCTATTATAGTTGAACACAGAAATCTGCAGTGTCTTTATTTGTTTTTATGTTTTAAACAATTTCACCTCTTCTCCCCACTCCTA
TCTTCTAAAGAAATATCAAGCAAATGCTAAGGGCCATTTCCATGATTCCTCAGAGCTCCCCCAAAGAGGAGAACAGTCCCTCCCACTCGA
TTCCTTCAGCTTCATTCAGGAAGACACAGGGAGGAGAGATGCTGCTTCTGCGCTTTGCTCTCATTCCTCTCTCATGGCCTTGAAATGTAT
TATTATGCAAATGTGAATTTTGATACTGAATTTAAGAAGAGGTTGTTGGATTTTTTTTTTTTTTTTTTTTTTTTTCAAAAAAAAAAGTCC
CACATGTGGTCATCGTCGCTTCTTTATGTTGTAAGGTGAATTGTAACTATGCATTCTGCAAAGGGGGTGGGGAGGAGAGGGCAGAAAGGG
GAAGGGAGTAGCGTTGCATCCTTGTTCTTCAGTTTCTGTGTCCATGGTGTCCCCGTGTCCTGGAGGGGAAGGGGAGTGAGAGACGAATGT
GGTAAGGTCAGCACAGTGAGATAGAGACCTCTGAGTCCTCTTGCCACTGTTGCTGGCAGGTCTGATGGCCAGGTAAATTCCAGGGGGCCT
GCAGTTCCTGTCAACCAATGTGGTTCAGGATTCTTGATCCTAGCCGTGCAGTGTTAATCCAGTGCAGCAATGGAACTCCACAGGCTCCAG
TGTTCTCTGGAAAAAGTACTCATCCTTTCCTGAATTCAGAGCCCTTCAAGCTCAGGAAACCACGCTTCACTCGTGCTGACCTGAAAGTTA
ATCTTTAGGTCGATTTTGAAAAACTCCGCCTCCTCTCTCCTTTTTAATATTTCTTTCTTCCTTTTTAATCATGTTTAAGTGAACTTACTC
TTAGTTATAAGGAACTGTCCTGCTTTGTGGGGAAGAGGGCTGTTGCTTGTCAGGCAAAAAAGTTTTCTCTTCCTACCCACCATCCCTCTC
TCTGCTTCCCTTGCATTTGGCAGGCTGTATGAAGCCAATGAGCTGCGAGGTGTTTTGACAGGGGAGGTCTGCATGCAGCCTCTTCTTTGT
CCTAACAATTCCTTTGTTGATCTTGCCTGTGATGAATCATAGCGCCTGCATTGCTCTGGTCTAGGCATTATTTGCAACACACAGTATCGT
AAGCGAGAGATTGTTCTGCCTATATTCAGTGTTTTCCATGCAGCAATTCTTCTTGTTGACGTTCACAGTACTGTAACGAGTAACAGACTT
GATCACAGTCTCCTCGTGCCTGTGCAGGGCTGCACAGGCATGATCTTATCAGGGTTCCAATCTGTTAGATTGCCTTTAAACAAAAAAAAC
AACAAAAAAATAAAATCCTGACGTTTCAACTGTCTCACACAAAATAATACCTCGAGGTACATTTCCCCCTGCAATGTAAACCCTTAACTC
CTCTCTCCTTTCTGACATCAGTGGATTATCCTTTTTAAAATATGAACATGTAAATAGCAGGATAACTTTAAAAAACATTTTCTTTGCTGT
GAAAGTAACCCTAAAATATGTTTTCTTCTTTTGTATTTTTTTGGTTTTTGTTTTTAAGCCATCAGAAGTTTCAGATCTTTACTCTTTCAT
GTTTAAGAAGAAAGAGCAGAGGAGGTCGGGGGAGCCGGTTTGCATTTGTGTTGGAGGGGTGTTATCTCCATTGCCTCCCACACAGTGACA
GCAGACCAGTATGTAAACCCTGTCTTGGCTGGGCGCGGTGGCTCACACCAGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCAT
CTGAGGTCAGGAGTTTAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAAATTAGCCGGACGCAGTGGCGCGCGCCTGT
GGTCCCAGCTGCTCGGGAGGCTAAGGCAGGAGAATTGCTTGAACCCGGGAGACGGAGGTTGCGGTGAGCCGAGATTGCACCACTGCACTC
CAGTGTGGGCAACAGAGCAAGACTTCGACTCAAAAACATAAAATAAACAAAAGACACACACACACACAAAAACCCTGTCTTAAATAGCTG
CCATCTCTTCCAGCAATCTAGTGCCAGGGTAAGAAGTGTCTGAATTTCTCTCTTCCAGCAGATCCATCCCCTGCAGGGACTCCAGAATGT
TCTCCACACAATACCTGGAGCTCTCAACCTTTCTTGGTTCAGACACACACATACACACCCCTTGAGTAACTCAGTATCATTTTGTAGTTC
ACAGAAGGATGTAGTCCCTGGCATTTTGGTTTGCACTGTAGAATCCATAGCCTTGTCACTTTGTTATGCTCTGGAAATGTACTGATTTCT
TACTTGGGAGGAAACTTGTGTAAGGAGATGTGCAAACCACCCTGAAAGCCATGTGCATCCTCACCTCTTCCATTACCCCCTCCATGAGCT
CGAAGCGACATTAAGTAGAGGGAAATGCTTTTAACAAATGCTGCTCATGTGGATCTGTCAGCTATTGCTTGCCTAGATTTGGGCACCCAT
GAAGCAGGGTTGGAATGGATCATTTTGAATTGCTTCTTTGCAGACACCCCCTTCGCCCCCATCTTTAAGATAAACCCTTTACTAGTCAAG
AAGCCCTTTTCAGTTGGATCTCACTGATCTTGTATAGTGACGACTTCCTTTGAAGGAAGAAGCTTGATTATAAGTGCATGCATATTATCC
ACCCACCTTCTGATTTGGGCACTGTTCACCTTGGAATTTTATTTATTTTGTTTATCTGGAGGCCCTTTTTCTATCAGTCTCTGATCCCTC
ATGGGTTCTGCCTGCCCTTGTATCTCTTGTACAATGCTCCCAAAGGGCTTTGCTGATCTCTGCACTTCTTTCCTGGGACACTCCCCCCAC
CACCACCCTTTGCACACACCAGTGACCAAAGTGTATGCAGTGATCTCACAGAAGACATCAAAAATGGTGCATGCACCGTGAATGTGCTCA
CAGAGACACGTGCACAAGATTCTGCACCCTTGGCCTTAATCTCAGTATGACTTAAGGTGCAGGAACATTTTTAACAGGTTTTAAAAAAAC
AAAAAACCCTTCTGGGAGGAAAAAAATAAAAAGCAGATACAACAGCTCAACTGTTCCCACTCCTAACTCTCCACTATGTGCTTATAACTT
CACATTCTATGCCCTCCCCGCCACCCACCTCATCCCTGTTCTGCGTAACCAAAAAACAGACAACAAAAGCAACCTGAGGAGAGGTTTCTG
GACTATTTTATCTGTCTCCATTTAGATGGAGATATAAATGCTGCTTTGGGTTCCATAATCCTAGGGGGCTATGTTTACATAGTAAAATAC
ATCCTACCAAATCAGGAAACAGTGAATAATGGGAGTCACTTCACAGAGACGCAGGAGGACCTGGGGGGCGTAGCAGAGGAGGATAGGTAG
AGAAGTACCATTTTAATTATTTGTGACTTGTGGCTTCCTTCCTCCTCTCCTCCTCCCTCCACGTCTCTCTTTGCCCCCTTTAGACAGAAG
GTGCAGAAAAGGGCATCAAAAAGAGGCTGGATTTTTTAAAAGGCAGCTTTCCAACTTTGCACACAAACAGGTAACAGGAAGGTACAGCAA
AAATCCTCTCATCTGAAACACTGTCAGCAGAAACAAAACCTGTAAAAATGACTAATCAGCTGCACATATTGATGCTCTCTGCAAGTTACC
TTTAAGTGTTTTTTTTTTCTTATACTTGAAGTTGCTTTTACGATATTATTTTGGTGGCTTTCTTTTCTCTCTTTGATGGGCAATAGAGGA
AGTAGATAATGGGATTTAAGGACGCCTGGGGGAGAAAAGGGAGGATGTGGCATTGTCTTTTTTTTTTTTTTTTTTTTTTTTTTTAGCATA
GAGGTTTAATCAAACTCCCATATGTTGAAATTGCTCCTCATATTACTGGTTTTACATGGACACAGAAACTAGGCACTTTAGAGGTGCACT
TGCATGGCAGGCTGGGCCCCCTTTTCTATATTTTATTTTCCTTTTTAGTATAGTGGTACTTAAAATCACTGGTTCACTTAAAAAAACAAA
CAATAAAATGTTAAACTCTACTAATGTACAAATAAGCTGAAAAGTTGCATTTTATGTGTATTTTTTGCCATAGCAGGTACTGTATTTCTC
ATGCTGGATTTCAAAAAAAAAAAAAAAAGTATCAAAAACAAAAAAAACTAAAGGGTGGTGTTTTATTGGATTGTGACAGGTTGAGTAATA
AGGAATTAAGTCGTCGTCATTTCATTAAAACTGAGAGATGATGTAATGCATATATAAGAGTTTTCTGAAGGGTTTTTTTTGGGCTTTTAA
ACAGCTTATTTTTGTTTTTGTTTAGTTTTTTTATTTTATTTTATTTTGGAAAGATATGATTGTATTATGTGCAACTCAGTTGCTTACATT

>26760_26760_1_EP300-TNRC6B_EP300_chr22_41546202_ENST00000263253_TNRC6B_chr22_40681649_ENST00000301923_length(amino acids)=1578AA_BP=884
MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQTSLGMVQDAASKHKQLSELLRSGSS
PNLNMGVGGPGQVMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQPAMGMNTGMNAGMNPGMLAA
GNGQGIMPNQVMNGSIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKMGMMNNPNPYGSPYTQNPGQQIGASGL
GLQIQTKTVLSNNLSPFAMDKKAVPGGGMPNMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGE
VRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVGLGNPSSLGVGQQSA
PNLSTVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQSPQGMRPMSNMSASPMGVNGGVGVQTPSLLSDSMLHSAINSQ
NPMMSENASVPSLGPMPTAAQPSTTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYY
HLLAEKIYKIQKELEEKRRTRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPNQMMPRITPQSGLNQFGQMSM
AQPPIVPRQTPPLQHHGQLAQPGALNPPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNSPIMPP
GSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPS
LPAAPSADQPQQQPRSQQSTAASVPTPTAPLLPPQPATPGGSHGLFGNSTAQSRGLHTPVQPLNSSPSLRAQVPPQFISPQVSASMLKQF
PNSGLSPGLFNVGPQLSPQQIAMLSQLPQIPQFQLACQLLLQQQQQQQLLQNQRKISQAVRQQQEQQLARMVSALQQQQQQQQRQPGMKH
SPSHPVGPKPHLDNMVPNALNVGLPDLQTKGPIPGYGSGFSSGGMDYGMVGGKEAGTESRFKQWTSMMEGLPSVATQEANMHKNGAIVAP
GKTRGGSPYNQFDIIPGDTLGGHTGPAGDSWLPAKSPPTNKIGSKSSNASWPPEFQPGVPWKGIQNIDPESDPYVTPGSVLGGTATSPIV
DTDHQLLRDNTTGSNSSLNTSLPSPGAWPYSASDNSFTNVHSTSAKFPDYKSTWSPDPIGHNPTHLSNKMWKNHISSRNTTPLPRPPPGL
TNPKPSSPWSSTAPRSVRGWGTQDSRLASASTWSDGGSVRPSYWLVLHNLTPQIDGSTLRTICMQHGPLLTFHLNLTQGTALIRYSTKQE
AAKAQTALHMCVLGNTTILAEFATDDEVSRFLAQAQPPTPAATPSAPAAGWQSLETGQNQSDPVGPALNLFGGSTGLGQWSSSAGGSSGA

--------------------------------------------------------------
>26760_26760_2_EP300-TNRC6B_EP300_chr22_41546202_ENST00000263253_TNRC6B_chr22_40681649_ENST00000335727_length(transcript)=18523nt_BP=4036nt
CTTGTTTGTGTGCTAGGCTGGGGGGGAGAGAGGGCGAGAGAGAGCGGGCGAGAGTGGGCAAGCAGGACGCCGGGCTGAGTGCTAACTGCG
GGAGCCAGAGAGTGCGGAGGGGAGTCGGGTCGGAGAGAGGCGGCAGGGGCCGAGACAGTGGCAGGGGGCCCGGGGCGCACGGGCTGAGGC
GACCCCCAGCCCCCTCCCGTCCGCACACACCCCCACCGCGGTCCAGCAGCCGGGCCGGCGTCGACGCCTAGGGGGGACCATTACATAACC
CCGCGCCCCGCGGCGTCTTCTCCCGCCGCCGCGGGCGGCCCCGAACGGAGCCCCGGGGGGCGGGCGCTCCCAGCACCTGGCCGCCGGCGG
TGGGGGCCGTAGCAGCGGCCGTATTTATTTATTTTCCGCGGGAAAGGAAGGCGAAGGAGGGGAGCGCGGCGCGAGGAGGGGCCGCCTGCG
CCGCCGCCGGAGCGGGGCCTCCTCGGTGGGCTCCGCGTCGGCGCGGGCGTGCGGGCGGCGCTGCTCGGCCCGGCCCCCTCGGCCCTCTGG
TCCGGCCAGCTCCGCTCCCGGCGTCCTTGCCGCGCCTCCGCCGGCCGCCGCGCGATGTGAGGCGGCGGCGCCAGCCTGGCTCTCGGCTCG
GGCGAGTTCTCTGCGGCCATTAGGGGCCGGTGCGGCGGCGGCGGCGCGGAGCGCGGCGGCAGGAGGAGGGTTCGGAGGGTGGGGGCGCAG
GCCCGGGAGGGGGCACCGGGAGGAGGTGAGTGTCTCTTGTCGCCTCCTCCTCTCCCCCCTTTTCGCCCCCGCCTCCTTGTGGCGATGAGA
AGGAGGAGGACAGCGCCGAGGAGGAAGAGGTTGATGGCGGCGGCGGAGCTCCGAGAGACCTCGGCTGGGCAGGGGCCGGCCGTGGCGGGC
CGGGGACTGCGCCTCTAGAGCCGCGAGTTCTCGGGAATTCGCCGCAGCGGACGCGCTCGGCGAATTTGTGCTCTTGTGCCCTCCTCCGGG
CTTGGGCCCAGGCCCGGCCCCTCGCACTTGCCCTTACCTTTTCTATCGAGTCCGCATCCCTCTCCAGCCACTGCGACCCGGCGAAGAGAA
AAAGGAACTTCCCCCACCCCCTCGGGTGCCGTCGGAGCCCCCCAGCCCACCCCTGGGTGCGGCGCGGGGACCCCGGGCCGAAGAAGAGAT
TTCCTGAGGATTCTGGTTTTCCTCGCTTGTATCTCCGAAAGAATTAAAAATGGCCGAGAATGTGGTGGAACCGGGGCCGCCTTCAGCCAA
GCGGCCTAAACTCTCATCTCCGGCCCTCTCGGCGTCCGCCAGCGATGGCACAGATTTTGGCTCTCTATTTGACTTGGAGCACGACTTACC
AGATGAATTAATCAACTCTACAGAATTGGGACTAACCAATGGTGGTGATATTAATCAGCTTCAGACAAGTCTTGGCATGGTACAAGATGC
AGCTTCTAAACATAAACAGCTGTCAGAATTGCTGCGATCTGGTAGTTCCCCTAACCTCAATATGGGAGTTGGTGGCCCAGGTCAAGTCAT
GGCCAGCCAGGCCCAACAGAGCAGTCCTGGATTAGGTTTGATAAATAGCATGGTCAAAAGCCCAATGACACAGGCAGGCTTGACTTCTCC
CAACATGGGGATGGGCACTAGTGGACCAAATCAGGGTCCTACGCAGTCAACAGGTATGATGAACAGTCCAGTAAATCAGCCTGCCATGGG
AATGAACACAGGGATGAATGCGGGCATGAATCCTGGAATGTTGGCTGCAGGCAATGGACAAGGGATAATGCCTAATCAAGTCATGAACGG
TTCAATTGGAGCAGGCCGAGGGCGACAGAATATGCAGTACCCAAACCCAGGCATGGGAAGTGCTGGCAACTTACTGACTGAGCCTCTTCA
GCAGGGCTCTCCCCAGATGGGAGGACAAACAGGATTGAGAGGCCCCCAGCCTCTTAAGATGGGAATGATGAACAACCCCAATCCTTATGG
TTCACCATATACTCAGAATCCTGGACAGCAGATTGGAGCCAGTGGCCTTGGTCTCCAGATTCAGACAAAAACTGTACTATCAAATAACTT
ATCTCCATTTGCTATGGACAAAAAGGCAGTTCCTGGTGGAGGAATGCCCAACATGGGTCAACAGCCAGCCCCGCAGGTCCAGCAGCCAGG
CCTGGTGACTCCAGTTGCCCAAGGGATGGGTTCTGGAGCACATACAGCTGATCCAGAGAAGCGCAAGCTCATCCAGCAGCAGCTTGTTCT
CCTTTTGCATGCTCACAAGTGCCAGCGCCGGGAACAGGCCAATGGGGAAGTGAGGCAGTGCAACCTTCCCCACTGTCGCACAATGAAGAA
TGTCCTAAACCACATGACACACTGCCAGTCAGGCAAGTCTTGCCAAGTGGCACACTGTGCATCTTCTCGACAAATCATTTCACACTGGAA
GAATTGTACAAGACATGATTGTCCTGTGTGTCTCCCCCTCAAAAATGCTGGTGATAAGAGAAATCAACAGCCAATTTTGACTGGAGCACC
CGTTGGACTTGGAAATCCTAGCTCTCTAGGGGTGGGTCAACAGTCTGCCCCCAACCTAAGCACTGTTAGTCAGATTGATCCCAGCTCCAT
AGAAAGAGCCTATGCAGCTCTTGGACTACCCTATCAAGTAAATCAGATGCCGACACAACCCCAGGTGCAAGCAAAGAACCAGCAGAATCA
GCAGCCTGGGCAGTCTCCCCAAGGCATGCGGCCCATGAGCAACATGAGTGCTAGTCCTATGGGAGTAAATGGAGGTGTAGGAGTTCAAAC
GCCGAGTCTTCTTTCTGACTCAATGTTGCATTCAGCCATAAATTCTCAAAACCCAATGATGAGTGAAAATGCCAGTGTGCCCTCCCTGGG
TCCTATGCCAACAGCAGCTCAACCATCCACTACTGGAATTCGGAAACAGTGGCACGAAGATATTACTCAGGATCTTCGAAATCATCTTGT
TCACAAACTCGTCCAAGCCATATTTCCTACGCCGGATCCTGCTGCTTTAAAAGACAGACGGATGGAAAACCTAGTTGCATATGCTCGGAA
AGTTGAAGGGGACATGTATGAATCTGCAAACAATCGAGCGGAATACTACCACCTTCTAGCTGAGAAAATCTATAAGATCCAGAAAGAACT
AGAAGAAAAACGAAGGACCAGACTACAGAAGCAGAACATGCTACCAAATGCTGCAGGCATGGTTCCAGTTTCCATGAATCCAGGGCCTAA
CATGGGACAGCCGCAACCAGGAATGACTTCTAATGGCCCTCTACCTGACCCAAGTATGATCCGTGGCAGTGTGCCAAACCAGATGATGCC
TCGAATAACTCCACAATCTGGTTTGAATCAATTTGGCCAGATGAGCATGGCCCAGCCCCCTATTGTACCCCGGCAAACCCCTCCTCTTCA
GCACCATGGACAGTTGGCTCAACCTGGAGCTCTCAACCCGCCTATGGGCTATGGGCCTCGTATGCAACAGCCTTCCAACCAGGGCCAGTT
CCTTCCTCAGACTCAGTTCCCATCACAGGGAATGAATGTAACAAATATCCCTTTGGCTCCGTCCAGCGGTCAAGCTCCAGTGTCTCAAGC
ACAAATGTCTAGTTCTTCCTGCCCGGTGAACTCTCCTATAATGCCTCCAGGGTCTCAGGGGAGCCACATTCACTGTCCCCAGCTTCCTCA
ACCAGCTCTTCATCAGAATTCACCCTCGCCTGTACCTAGTCGTACCCCCACCCCTCACCATACTCCCCCAAGCATAGGGGCTCAGCAGCC
ACCAGCAACAACAATTCCAGCCCCTGTTCCTACACCTCCTGCCATGCCACCTGGGCCACAGTCCCAGGCTCTACATCCCCCTCCAAGGCA
GACACCTACACCACCAACAACACAACTTCCCCAACAAGTGCAGCCTTCACTTCCTGCTGCACCTTCTGCTGACCAGCCCCAGCAGCAGCC
TCGCTCACAGCAGAGCACAGCAGCGTCTGTTCCTACCCCAACAGCACCGCTGCTTCCTCCGCAGCCTGCAACTCCAGGCGGTAGTCATGG
TTTGTTTGGAAACAGCACAGCACAATCGAGAGGTCTGCACACACCCGTGCAGCCACTAAATTCTTCTCCCAGTCTCCGGGCGCAAGTGCC
TCCCCAGTTTATTTCCCCCCAGGTTTCTGCCTCAATGCTCAAGCAGTTTCCCAACAGTGGCCTGAGTCCAGGTCTTTTCAATGTGGGGCC
CCAGTTATCTCCTCAACAAATTGCCATGCTGAGCCAGCTTCCACAAATTCCCCAGTTTCAGTTGGCATGTCAGCTTCTCTTGCAGCAGCA
GCAACAGCAGCAGTTGTTACAGAACCAGAGAAAGATTTCTCAAGCTGTACGCCAACAGCAAGAGCAGCAGCTGGCTCGAATGGTGAGTGC
ACTGCAGCAGCAGCAGCAGCAGCAGCAGAGGCAGCCAGGCATGAAGCACTCGCCCTCTCATCCTGTTGGGCCCAAGCCGCATCTGGACAA
CATGGTACCCAACGCATTGAATGTGGGGCTCCCAGACCTTCAAACCAAAGGGCCAATACCTGGATATGGTTCTGGCTTCAGCTCTGGCGG
CATGGACTATGGCATGGTTGGTGGGAAGGAGGCTGGAACCGAGTCTCGCTTTAAACAGTGGACCTCCATGATGGAGGGGCTGCCCTCTGT
AGCCACACAGGAAGCCAATATGCACAAAAATGGCGCTATAGTGGCCCCTGGTAAAACCCGGGGAGGGTCACCGTACAACCAGTTTGATAT
CATCCCTGGTGACACACTGGGTGGCCATACGGGTCCTGCTGGTGATAGCTGGTTACCTGCCAAATCTCCACCAACAAATAAAATCGGAAG
TAAATCCAGCAATGCCAGTTGGCCTCCAGAATTCCAACCAGGAGTGCCATGGAAAGGTATCCAAAACATTGACCCTGAATCTGACCCCTA
TGTCACCCCAGGAAGTGTGCTGGGGGGTACAGCCACATCTCCCATTGTAGATACTGACCACCAACTGCTGCGGGATAACACCACAGGGTC
TAATTCTTCCCTCAACACCTCGCTGCCTTCACCTGGTGCCTGGCCCTACAGTGCCTCTGACAACTCCTTTACCAACGTTCATAGCACTTC
AGCAAAGTTCCCTGATTACAAATCAACATGGTCCCCAGATCCCATAGGACACAACCCCACTCATCTCTCCAACAAGATGTGGAAAAACCA
TATTTCCTCCAGGAACACTACACCGCTGCCCCGCCCACCTCCTGGTCTGACCAACCCCAAACCATCATCTCCCTGGAGCAGCACAGCACC
CCGATCAGTCAGGGGGTGGGGGACACAGGACTCACGGCTCGCCTCGGCCTCTACCTGGAGTGATGGTGGCTCAGTTCGTCCTAGTTACTG
GCTGGTTCTTCACAATCTCACCCCACAGATTGATGGGTCAACCTTGAGAACGATCTGCATGCAGCATGGCCCACTGCTGACATTCCATCT
GAATCTAACCCAGGGCACTGCCCTGATCCGATACAGCACCAAACAGGAGGCGGCCAAGGCCCAAACTGCACTGCACATGTGTGTGTTGGG
AAACACTACCATCCTTGCTGAGTTTGCCACTGATGATGAAGTCAGCCGCTTTCTGGCACAAGCTCAGCCCCCTACACCTGCAGCAACCCC
AAGTGCGCCAGCTGCGGGGTGGCAGTCGCTGGAGACCGGCCAGAACCAGTCAGATCCCGTGGGACCTGCTCTGAATCTTTTTGGTGGGTC
CACTGGGCTCGGGCAGTGGAGCAGCAGCGCTGGTGGCAGCAGCGGGGCCGATCTTGCTGGCGCTTCATTGTGGGGGCCCCCAAACTATTC
TTCTAGCTTATGGGGAGTCCCAACGGTGGAAGATCCCCATAGGATGGGCAGCCCTGCTCCTTTACTACCTGGTGACCTTCTGGGAGGAGG
GTCGGATTCAATCTGAACTTAGAACTTTCAACTCTGACCTCGTGACCTTTTTTGGAACAGCAGCAGCACTAACTTGACCTTTTCGTTTTT
TTTTTCAACTTGCAATAAATACATTTTTAAAAGGAAAAAAGAAAACGGAGAGAAAAAAAGGTGGGTCATTGACAGACTGTCTGAGCACAT
AGTTGCCTCCCTTATAACTTCAGTTTTTTCGTTTGGAATATGAATCCAAAAAGAGAACATATCACTCTTGAAATACTTGAATCATGAACG
CCAACCTAGAAAGACAATGTGAAGCAAGTACACATACCATTTAAATTTAAACACAAAAAAATTAAAAAAATTAGTTTCTAGTTTTTCACT
TTTTTCATGTTATATGGAAGTTGTTGCTAAGAAACATATATACTGAAAAAAAATAGCTTTTTAACTTTGTTTGCACTGGGTGTGTTTCCG
TCCTTAGGTCTACCATGTTTGGGAGGGAGGGAAATTCAAAAGAATTGTTGGGGGAGGGGGGAGGGAAGACTTGACGGAGCCTCACTTTAA
AAACAAAAACACAAAAAACCTAAAAAAAAAAAAAAGGAAAAAATTTGTGATTGGCTGGTTGATAAATACCAGTGTGTTCTGGCACATGTA
ACTGCCCAGGCATGCTCGTTCTGGTGTGTGTGTGCACGTGTGTTCATGTGCATTCGCGTGCATCCTTCTCTGTCTCTGTGTGTGTGCCTG
TGTTCTTCCCTTCTCCCCTGCCCCACCCTGACTTCTCAGAAAGCTGCATCGCTGACAGTCTGCAGGCTGGCTGGCCGGCCCATCTGCTTT
TTATTTTATTTTTTTAACTATGAGAACACACAGGCCCGGAGAGCCACTGCTACTAAAGCAACTCCATTGGGCTGCATTAAGATGAACAGA
GTGCTTTTTAATGATGAAAGCAGGGAGCTCCTTTCCATTTGCAACTTAGCCTGAATGTGGGGTTTCTCTGGCTGTTCTTTTGACCTAGCA
GTAGAGTGGAGCACTGCCAAGTCCAAAAAACTAGAGCAGGAGGTACCTCTTGGAGCAACGGTGTGTTTATTTCTGTTTTTTTTTTTTTTT
AAGTGAATGGCCACCAGGCACATCTGAGTATCTGTTAAGTTTCATGCAGGCCTTTTCGTTAGTTTGAAATGGGAACGGAAGATAACTTTT
GATGATGCGATGTCTCAAAAACAGAGAAACTTTGTTCCCTCTTTCCTTATGATCAGGTTTGAGAAATTCTTCAAAAAATTAGGTGAAGTT
GAGTTACATATTTCTGTTGGTTGGTTCTCTTTTTCATTTTATGAAAACAGAAAAGAATAAGTGGTGAGCAGCCTCCTGAAAGCATCTGCA
GCTACTCCCTCTGCTCCTTTCTCGCCGAGCGTTACCTGTGCCAGGCCGTGGCGCGTTACAGCACCAGGCCATCACTGACAGAAACGTTTA
CTTAACGAATGTTCTTAAACCAGTGTGTACTTCAAGCGTTTCCTTTTGTTTCTCTGTGTTGTGTATTTCCTGTGTATGTGGTTTTGCTTA
GGCAGGTATAACTTAGCGAAGACTTTTAAGTATTGCACCTTTTTTTGATTTTTGACCTCTTCCCCCCACCTTGTAATTTTGCTTTTTTAA
TTTCGGTATTTAAATACTTTTTTTTTTTTTTAAGCATCAATGTAGTAGTACTCTGGGCCGAACAGGGGTCAACGTTTAATCTACAGTTAT
CACCAACATGTATGTACTTATGTCGGAATCAAAATGTATCAAACTGCTTATTGTGAAGAGAATTATAGCAGACCTGAAGGGGGCGAAAAA
CCAGATAGGGTGGGGGGATGGATGCCGGTGACGTGCTAGCACTTGTGTGGACATCCCAGTCTGCATTATGCTGTTTAACATAAAGTGCCG
ACATTTTGTACCAGCAAATACCTGCCCATTCCAACCCTTGGTGGGAGCAGACCTCTACTGTCCTCTGTAACTTGCTGCTATTGAGGACAA
GGGAGTTTTTCTTTCTTTAGCGTCTTCAGTGAAGGATACAATACAACAATGCCTAATGTATTTGACTTTTTAGCTTGTGTCTGTGTGTAG
GTGGGTGGGTGGGTGTGTATAGGAAAAGCCTAAAACAAGTTATTTGCATTTCAGTGGTTTTGTGAGACAAAGAATGGGAAATTCTGTAGC
CCTTCTGGCTTACCCTGTTGATTATAAACCTAGCCTCAAAAGAGATTGACAGGCATGACTCAAGTGAGTGTTCACATATACAAGCCTGCA
TGAGCCCTCTGTGGGTAGGTGGTCACACTTGGCATCTGCAGCATTGACGTGGCCCCGCTGGGTGCCTTGAGCATGCCCTCTTCCTGCTCT
GCAATTTGAATCACCACCGTGCCCCTTCCACCACTGTTCCCCATGCAAAAGCTCTGCTTCCAGCAGCCCCCACTGACCGCTCTCTGTGTG
GAGCAAAGTGCTGTCGTGCGGTGACCACCAGGTGAAGAGCAGCTTGTATTCAGACATCTAGAGAAGGTTAAATCTTAGTGTCCCTGGGCC
AGGAGCATATCCCAAGGCTCCTGCGAGCCAGTGGCGACCCTGTCCACTGCCGCTCTTGGTTCACTGCTGTGTCCTGCCCCACCCTCCTCT
CCTCCTGCCTGTTGGTTCCTTGACCTGCACTATGGGTTAGTTGAGTTCCTTACGATACTACGGTGAAAGCCGGGTGCTAGAGCCCCTCTT
GTTTACAAGACATAATGAGGGATTTGAAATATGTAAAAATAAACATGAGAAGCTAAAATGTTCTTCCATCATAAGCTTAAAGGGAAAAAA
ACTAAAAACTTTAAAAAAAAAAGACCAAAAAGTGCGTATATATATACATATAAATATATATTTTAGATGAAGACTAACTCTGGGAGCATT
TAACAGTGTTTTTTGTTTCTGTTTTTAACATTTGTTTTCCTGCTTTAAAATTTGCAAGCATTCTCAGGAATTCTAGGGTAGGAAGCCAGT
TTTTTGAAGATGGTTTATTTAACCATATCTTATCCTAGAGAGATGGCTGTTTCTTTCCTGTTAATAAACTTTTACAAGTTCCTGAAACTT
CAGAAAGTTTAAACAATTTTTACTTAAAAAAATGTAAAAAGAAAAGTCTCCAAACATTATTGTCATACTGGGGATCACACATTTTAAAAC
ACATAGAAATATTTTTTAAAAATTATCAATTTAGCAGCAACAGGTAAATTCATTATCTTAAAAATATGGGAGAAGGATTAAGCTTTGTAA
GAGCTCGATCATGGATTCTTTTGAAATTGTGTGTAGTTTAATGGGAGAGTGTTTGGTGTATATAGATGAGAATGCCATCACTTTGTTCCT
TTCCATTTGAGACTGAACTGAAATCTCCCCTAGTAATTTTTATTTTTTTAAAGGAACCCTTCTCCTTGTCCCCACAACCCCAGCAACAAA
AGAAAGGAAGGAAGGAAGAAACAACAGCTTAAAAAAAAAAGTAATCTGTAAAATAGTACAGTTGGATTGCTGAGAATCTATGTAAAGAGT
TAGGAAATATAGGTTAATAATTTTTGGAACAAATTTTAAATATAGGCATTACTAGAGGAAAATTATCTATGGACTGTCCTATTAATGAAG
AATGTCTGTCTTACCTCCGTTTGTTTTGGGAGGAGGAGAAAATATAGAAGAATCTAATAAGGAACAAGTGATTTTACTTTTTTAGCTCCC
AGCTACTGTTGTGCTCGTTTTAATTGCTGTTTTGAAGATCTGCTGCTTAATTATCCCCATCCCTTAGCCGGAGATGTGGAGTGTTTCCTT
TCAGTTTTTGGTGATGTTGAATTCTTTTGTATTCCCTCCTGGGGCCAGGGGTCAGAATTCCCAAGCATGACCACAGCTTCTTTTAAACAT
TAAGCTTCCCAGTGGGAAGGAAACTCCAGCTCGACAGGTAAAGGGAGTGGGTGGGGTTGCTGCCTGCAATTTCTCTAAAACCGCTTTAGT
GCCTTCGTACATACACCCAGACATCCTGAGCAAGGGGGACGCACATGTGTGTGTGTGTGGTCCAGTCACTCCACAGATGTAAGATACTCA
CCCATAAAGGAAATTGGAGTGGTTCTGGACAGGCCCCAAAGGCAGTGGGCTGAATTTAAAATAAATAAACAAACGTCAAGCAAGTTAATA
TGCTTATGTCTCAGTAATGTAGAATGCCAAGTTCCTTCCTGTGTCGTGTGCCCTCCATTACTGTGCATTGATTCCTCCAGGTGTGTAATT
GTGACAACTGCAGTGATTTGGAAAGTCTCTTTGTCTTGGGCAAATAGAAGGGGTTCCTGTTGTTCTGCTCTTGTCCTTCGTCTCCTCCCC
TTTTCCCCCAGACCTCCCCCTTCTTTTTGTCAACTTGCTGGGAGCTTTGCTTTATTGGTTGGCAGTGACCTAAGAACAGGATATGGTGAG
GATGTCATGGAAGAGAAGAGCTCTTTCCGTGGTATTCTTTGGCAAGAGCCATGTCTACTAAGAGGTTAGATGACTTCAGTATACTTATAA
AATTCAGTGAGAGTGCCTTCTTCTCTTCTACCACACTCTGGCATAGATACAGGCTTGCTGGTCACCTCTCATTACATAGATTTATTTTAA
AAACATTTTGATTATGTTAATTTGAGCTTTCCCTTTTTTTTTTTTAACTACTTTTTAAAACACTTGATTACTAGTGGCTTAGAGGTGTGT
ACATCTCCTGAACATCACAAACTTGGTTTCTACCTACCACACGAGTAGCCAAAAGAAAAGAAGCACTAATAGAGAAAGGGGTGTCTCACA
CCAGACAGAGGACCTCTGCTGTCAATTAGATCCAGTATCATGACCTAACTTTAAGTGTGGAAAAGAGTTCAGATCTCTGAGACACTGTGA
AGAAATGGATGGCTCATGTAACATCTCTGATCCCTCAGTCCCCAACCCTGGACGTGTTTCATTTACAACATTCATAGGAGTTAACTTAGC
AGTGTTGCAAGTTAAGGTTCCAAACCAAATTATTTAATCAGTGTCCCCCCAATAAATCACTTATCCATTTATTGCTAGTTAGTTTTATTT
ATAGCAACTTGATTTCCTATGAGTATGGCTCCTGTTGTAAGAATTTTCCCACCTCTTCTGACATGAATGTAGCATAAGTTAGCAATCGGT
TCTTCCAAACTCCTGTGGGTTGAATATGGTATAGAAGGTATGCAAGAGGAAAAAGAAAGGAAAAGATAAAACTCCTGCCTGAGAATTTGG
AAGCACCTTTATTAACACATATATCTCGCAGAAACTAGAAGCTCATAGGCTGTTAACTTTTTGCAACTATTCACTCATTTTTACCACTTT
TTTTTTTGGGTGAGGGGGTGATTTTTGTAAGGTTAACAGCCAGATTCCATTTTGACCTCAGATGCTGTGTACTTTTTAATTTCATTTTTT
ATATTCTGCCATCTTGACTCTTCTCTAAAACAGAATGAAAATGTCTGCATGCTGAGCAAAATGCTTACGCCAAGCCTGTTTTTCTCTGCA
GAGTAAACAGGATGTTTTCAGCAGACTTGGCTCTAATAGCCATCTCTAAGATTAGGGAACAATTGAGTCTTTATGTAGAAAAGATCCATT
TTTTCCCCATCCTCAGAGTTAAAATTCAACATTTAAAGCTTTATCGGTTATTGTTTTAGATTTGAGATTTTTGTTTTTAAGTATCTATAA
GATCTTTAGAAGTGAGATAAATTTTTCGCTGGTTAAAAAAAATCAAACTTTCCTCTGCAGTGTTTTTGCCAAGTTTTGTCACACTTCATG
TGTATGCATTAACTATACTTCTTAGTGTTACTGCAAAAAAAAAAAACAAAAACAAAACAAAAAAAAGCCTTGTTCTTTAATTGTGTTTTT
CCTCCTGTGAGTGGACAACTAAAGCCGCGTGATGATGCGGATGAAAATATTCTGGTCTGTGTGTATACAATGAATTGTCAGTCTTCAGAC
CTCATGGTCGTTAAGAAAATAGGGAACTCACAAACCCTGCTGCGCACTACATTTACTTCTTTATCTGCAAGTACAGGGAGTCCATACAGT
CAAGAAACACACAGATACACATAATGCTATTGAGGACATTGTCATTCTGTAAGAAAACAGAATATTATCTAGATTTCCAGAGTTAGTGCA
GACCCTGTGATAACAGTCTGTGGGTTTGTGGCCAGCGCCAAAGGTGTGTGTATTTTCAGAAATGGTCCCTATTTGTCAGTGATAGTGTTT
TTTTTTTCTTAAGTTTGACAAAGGGGGTGGTAATATCACATTCTTTAGATTTGAAATAATTATCAGCTCCAAGAATCTGTGAACATAGTA
ATAACAATAAAAATTCAACATCGACCCTCCCTAACCTGCTCACCATACCTCCCCACCCCATGCCTCTGAAGAAAGAGGCCATGAACCTAC
GAGGTGGTAAAGGGGGACACAGGTCAGGGAGTGGAGAGCTACTCCTCCAGCAGCTCAGCACCCACACTGCCCGCATGCGTGTGGCCACCG
GGACCAGATCCCGAGTGATTGTGGCATACCCCTAATATTTGAGTAGTTTTTAAGCTGTCAGTCTCTTGTCATAACCTCCTACCGCCACCC
AAAAAAGTAACGAAAGTTGCAGTAACTGCCAGTGTTTGCCTCACCAAATTTAAATCGTTCCCTTTTCAGTTAGCTATATACCTGAATTTG
TTTTTAACAAGAAACTGTACATGGCCAGGAAAAATGGTACTACCTTGGCCAAAGGGTCTTTGCAAAAAGCTCAGTCTTCAGTTCTTCACT
GTGACAAATGCTTATCTTGTTCATGGGAGGGGAAAGATCAGATAAATAGGCAAGAAGTACTCTGTTTTAAATAAAGAATAAATAGTGTCC
GTTTAAAGCACTTTGTGCCTCAACTTCATTTTTAAACTGTAAATCATTGCTTTGGAAATAAATTCCCAATTATAATTGACCCATATCTAG
CCAATATCAACAAGTTGGGATGGTTTTTGTTTTTTTCTTTTTTTTCAAAAAGGGAAATTCCTCTTTACTGCTCACAGTAAGCTGCAAAAG
AAAGTTGTCAAGGTGGCTTATGATGCTGTTGTAGCAGAGCTGTGAAAGGAAGTGCTTTGCTTTCTCTCCCGCCTTCCGGAATCTGGCGTT
CCTTCCCCTTCGGCTACTGAAAGGTGTGTACAACTCCCAGAGGGGTGGCTGTAAAAGTTGACTGGAGGCAAAGTGGAGTGGCCTTATTGC
CAGGACTAGCCCTACAGAAGAGCTTTACAGAGAGGAGGACAGTACATCCTATGTGTGTTCGCCAAAAATGGGAAAGGTGGGTATTTAGGC
AAAACAAAATAAAAACCTTTGGAACCCTTTAAGAAGTTACATACCTTTTAAAGGTAGTATAGTTTCTCACCAAGTGATGCATTTTAGCAT
GACACTTCTTGCCAGAAATTTTGGGATAAGTTGGAATAAATGTGTTTAAAACATCATCCACCGCCCTTTTTAAATTTTGTCTAAGGAATT
ACTTAAGTATAGTATTTCTGAATGTGCCTTTGTGAGTACAGAGACCGTCCGTTCTAGGAAGAAGCTATCCGTTGGATACAAACAAACAGA
CGGTCAGCTTTAGTCATTAGGGAAGTCAAAGTTCCTCCTGGAAGTCCCAGGAGCAGCTGTTGAGATTTCATTAGCATCAATATTGCACAG
TGTAGAGTTGAGTGGAAGAGATTCTGGGACTTGGGAGAGGAGACAGGGGAAGGTACCCAGGCGACGCAGACCCACGTTAGTCCAAGAGCG
CAGGTTTACACATCTGCATTCCCTAGTTTTCTCCGTCTGTATGTTTGTGCTCATGTGGCTTTGGCTGTTTTGTTTTTTGTTTTTCTGTAA
GCACTGGAGAATTGGAATATGGTGATACTTGTGACACATTCATGCATGTAAACAAGGCATTTTCCAGCTTCTGCCGTGTGCAGAGCGGGC
AGCACGCTTTTACCCTTTGAGTCTGTGTCCTGAGGCGGCCATTACATTCCCACATGGGCGTCACATCACGTTGCTGTTGATGCAAACAGG
GTATTACACACAAGGAAAAGGGGTTTTGAAGAGTTAAGATTGAAGTGTTTGAGAAAGAAAAGAGAAAAATCTGAAATCATATTTTATTTC
TTCAGAGCTATTATAGTTGAACACAGAAATCTGCAGTGTCTTTATTTGTTTTTATGTTTTAAACAATTTCACCTCTTCTCCCCACTCCTA
TCTTCTAAAGAAATATCAAGCAAATGCTAAGGGCCATTTCCATGATTCCTCAGAGCTCCCCCAAAGAGGAGAACAGTCCCTCCCACTCGA
TTCCTTCAGCTTCATTCAGGAAGACACAGGGAGGAGAGATGCTGCTTCTGCGCTTTGCTCTCATTCCTCTCTCATGGCCTTGAAATGTAT
TATTATGCAAATGTGAATTTTGATACTGAATTTAAGAAGAGGTTGTTGGATTTTTTTTTTTTTTTTTTTTTTTTTCAAAAAAAAAAGTCC
CACATGTGGTCATCGTCGCTTCTTTATGTTGTAAGGTGAATTGTAACTATGCATTCTGCAAAGGGGGTGGGGAGGAGAGGGCAGAAAGGG
GAAGGGAGTAGCGTTGCATCCTTGTTCTTCAGTTTCTGTGTCCATGGTGTCCCCGTGTCCTGGAGGGGAAGGGGAGTGAGAGACGAATGT
GGTAAGGTCAGCACAGTGAGATAGAGACCTCTGAGTCCTCTTGCCACTGTTGCTGGCAGGTCTGATGGCCAGGTAAATTCCAGGGGGCCT
GCAGTTCCTGTCAACCAATGTGGTTCAGGATTCTTGATCCTAGCCGTGCAGTGTTAATCCAGTGCAGCAATGGAACTCCACAGGCTCCAG
TGTTCTCTGGAAAAAGTACTCATCCTTTCCTGAATTCAGAGCCCTTCAAGCTCAGGAAACCACGCTTCACTCGTGCTGACCTGAAAGTTA
ATCTTTAGGTCGATTTTGAAAAACTCCGCCTCCTCTCTCCTTTTTAATATTTCTTTCTTCCTTTTTAATCATGTTTAAGTGAACTTACTC
TTAGTTATAAGGAACTGTCCTGCTTTGTGGGGAAGAGGGCTGTTGCTTGTCAGGCAAAAAAGTTTTCTCTTCCTACCCACCATCCCTCTC
TCTGCTTCCCTTGCATTTGGCAGGCTGTATGAAGCCAATGAGCTGCGAGGTGTTTTGACAGGGGAGGTCTGCATGCAGCCTCTTCTTTGT
CCTAACAATTCCTTTGTTGATCTTGCCTGTGATGAATCATAGCGCCTGCATTGCTCTGGTCTAGGCATTATTTGCAACACACAGTATCGT
AAGCGAGAGATTGTTCTGCCTATATTCAGTGTTTTCCATGCAGCAATTCTTCTTGTTGACGTTCACAGTACTGTAACGAGTAACAGACTT
GATCACAGTCTCCTCGTGCCTGTGCAGGGCTGCACAGGCATGATCTTATCAGGGTTCCAATCTGTTAGATTGCCTTTAAACAAAAAAAAC
AACAAAAAAATAAAATCCTGACGTTTCAACTGTCTCACACAAAATAATACCTCGAGGTACATTTCCCCCTGCAATGTAAACCCTTAACTC
CTCTCTCCTTTCTGACATCAGTGGATTATCCTTTTTAAAATATGAACATGTAAATAGCAGGATAACTTTAAAAAACATTTTCTTTGCTGT
GAAAGTAACCCTAAAATATGTTTTCTTCTTTTGTATTTTTTTGGTTTTTGTTTTTAAGCCATCAGAAGTTTCAGATCTTTACTCTTTCAT
GTTTAAGAAGAAAGAGCAGAGGAGGTCGGGGGAGCCGGTTTGCATTTGTGTTGGAGGGGTGTTATCTCCATTGCCTCCCACACAGTGACA
GCAGACCAGTATGTAAACCCTGTCTTGGCTGGGCGCGGTGGCTCACACCAGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCAT
CTGAGGTCAGGAGTTTAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAAATTAGCCGGACGCAGTGGCGCGCGCCTGT
GGTCCCAGCTGCTCGGGAGGCTAAGGCAGGAGAATTGCTTGAACCCGGGAGACGGAGGTTGCGGTGAGCCGAGATTGCACCACTGCACTC
CAGTGTGGGCAACAGAGCAAGACTTCGACTCAAAAACATAAAATAAACAAAAGACACACACACACACAAAAACCCTGTCTTAAATAGCTG
CCATCTCTTCCAGCAATCTAGTGCCAGGGTAAGAAGTGTCTGAATTTCTCTCTTCCAGCAGATCCATCCCCTGCAGGGACTCCAGAATGT
TCTCCACACAATACCTGGAGCTCTCAACCTTTCTTGGTTCAGACACACACATACACACCCCTTGAGTAACTCAGTATCATTTTGTAGTTC
ACAGAAGGATGTAGTCCCTGGCATTTTGGTTTGCACTGTAGAATCCATAGCCTTGTCACTTTGTTATGCTCTGGAAATGTACTGATTTCT
TACTTGGGAGGAAACTTGTGTAAGGAGATGTGCAAACCACCCTGAAAGCCATGTGCATCCTCACCTCTTCCATTACCCCCTCCATGAGCT
CGAAGCGACATTAAGTAGAGGGAAATGCTTTTAACAAATGCTGCTCATGTGGATCTGTCAGCTATTGCTTGCCTAGATTTGGGCACCCAT
GAAGCAGGGTTGGAATGGATCATTTTGAATTGCTTCTTTGCAGACACCCCCTTCGCCCCCATCTTTAAGATAAACCCTTTACTAGTCAAG
AAGCCCTTTTCAGTTGGATCTCACTGATCTTGTATAGTGACGACTTCCTTTGAAGGAAGAAGCTTGATTATAAGTGCATGCATATTATCC
ACCCACCTTCTGATTTGGGCACTGTTCACCTTGGAATTTTATTTATTTTGTTTATCTGGAGGCCCTTTTTCTATCAGTCTCTGATCCCTC
ATGGGTTCTGCCTGCCCTTGTATCTCTTGTACAATGCTCCCAAAGGGCTTTGCTGATCTCTGCACTTCTTTCCTGGGACACTCCCCCCAC
CACCACCCTTTGCACACACCAGTGACCAAAGTGTATGCAGTGATCTCACAGAAGACATCAAAAATGGTGCATGCACCGTGAATGTGCTCA
CAGAGACACGTGCACAAGATTCTGCACCCTTGGCCTTAATCTCAGTATGACTTAAGGTGCAGGAACATTTTTAACAGGTTTTAAAAAAAC
AAAAAACCCTTCTGGGAGGAAAAAAATAAAAAGCAGATACAACAGCTCAACTGTTCCCACTCCTAACTCTCCACTATGTGCTTATAACTT
CACATTCTATGCCCTCCCCGCCACCCACCTCATCCCTGTTCTGCGTAACCAAAAAACAGACAACAAAAGCAACCTGAGGAGAGGTTTCTG
GACTATTTTATCTGTCTCCATTTAGATGGAGATATAAATGCTGCTTTGGGTTCCATAATCCTAGGGGGCTATGTTTACATAGTAAAATAC
ATCCTACCAAATCAGGAAACAGTGAATAATGGGAGTCACTTCACAGAGACGCAGGAGGACCTGGGGGGCGTAGCAGAGGAGGATAGGTAG
AGAAGTACCATTTTAATTATTTGTGACTTGTGGCTTCCTTCCTCCTCTCCTCCTCCCTCCACGTCTCTCTTTGCCCCCTTTAGACAGAAG
GTGCAGAAAAGGGCATCAAAAAGAGGCTGGATTTTTTAAAAGGCAGCTTTCCAACTTTGCACACAAACAGGTAACAGGAAGGTACAGCAA
AAATCCTCTCATCTGAAACACTGTCAGCAGAAACAAAACCTGTAAAAATGACTAATCAGCTGCACATATTGATGCTCTCTGCAAGTTACC
TTTAAGTGTTTTTTTTTTCTTATACTTGAAGTTGCTTTTACGATATTATTTTGGTGGCTTTCTTTTCTCTCTTTGATGGGCAATAGAGGA
AGTAGATAATGGGATTTAAGGACGCCTGGGGGAGAAAAGGGAGGATGTGGCATTGTCTTTTTTTTTTTTTTTTTTTTTTTTTTTAGCATA
GAGGTTTAATCAAACTCCCATATGTTGAAATTGCTCCTCATATTACTGGTTTTACATGGACACAGAAACTAGGCACTTTAGAGGTGCACT
TGCATGGCAGGCTGGGCCCCCTTTTCTATATTTTATTTTCCTTTTTAGTATAGTGGTACTTAAAATCACTGGTTCACTTAAAAAAACAAA
CAATAAAATGTTAAACTCTACTAATGTACAAATAAGCTGAAAAGTTGCATTTTATGTGTATTTTTTGCCATAGCAGGTACTGTATTTCTC
ATGCTGGATTTCAAAAAAAAAAAAAAAAGTATCAAAAACAAAAAAAACTAAAGGGTGGTGTTTTATTGGATTGTGACAGGTTGAGTAATA
AGGAATTAAGTCGTCGTCATTTCATTAAAACTGAGAGATGATGTAATGCATATATAAGAGTTTTCTGAAGGGTTTTTTTTGGGCTTTTAA
ACAGCTTATTTTTGTTTTTGTTTAGTTTTTTTATTTTATTTTATTTTGGAAAGATATGATTGTATTATGTGCAACTCAGTTGCTTACATT

>26760_26760_2_EP300-TNRC6B_EP300_chr22_41546202_ENST00000263253_TNRC6B_chr22_40681649_ENST00000335727_length(amino acids)=1578AA_BP=884
MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQTSLGMVQDAASKHKQLSELLRSGSS
PNLNMGVGGPGQVMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQPAMGMNTGMNAGMNPGMLAA
GNGQGIMPNQVMNGSIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKMGMMNNPNPYGSPYTQNPGQQIGASGL
GLQIQTKTVLSNNLSPFAMDKKAVPGGGMPNMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGE
VRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVGLGNPSSLGVGQQSA
PNLSTVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQSPQGMRPMSNMSASPMGVNGGVGVQTPSLLSDSMLHSAINSQ
NPMMSENASVPSLGPMPTAAQPSTTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYY
HLLAEKIYKIQKELEEKRRTRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPNQMMPRITPQSGLNQFGQMSM
AQPPIVPRQTPPLQHHGQLAQPGALNPPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNSPIMPP
GSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPS
LPAAPSADQPQQQPRSQQSTAASVPTPTAPLLPPQPATPGGSHGLFGNSTAQSRGLHTPVQPLNSSPSLRAQVPPQFISPQVSASMLKQF
PNSGLSPGLFNVGPQLSPQQIAMLSQLPQIPQFQLACQLLLQQQQQQQLLQNQRKISQAVRQQQEQQLARMVSALQQQQQQQQRQPGMKH
SPSHPVGPKPHLDNMVPNALNVGLPDLQTKGPIPGYGSGFSSGGMDYGMVGGKEAGTESRFKQWTSMMEGLPSVATQEANMHKNGAIVAP
GKTRGGSPYNQFDIIPGDTLGGHTGPAGDSWLPAKSPPTNKIGSKSSNASWPPEFQPGVPWKGIQNIDPESDPYVTPGSVLGGTATSPIV
DTDHQLLRDNTTGSNSSLNTSLPSPGAWPYSASDNSFTNVHSTSAKFPDYKSTWSPDPIGHNPTHLSNKMWKNHISSRNTTPLPRPPPGL
TNPKPSSPWSSTAPRSVRGWGTQDSRLASASTWSDGGSVRPSYWLVLHNLTPQIDGSTLRTICMQHGPLLTFHLNLTQGTALIRYSTKQE
AAKAQTALHMCVLGNTTILAEFATDDEVSRFLAQAQPPTPAATPSAPAAGWQSLETGQNQSDPVGPALNLFGGSTGLGQWSSSAGGSSGA

--------------------------------------------------------------
>26760_26760_3_EP300-TNRC6B_EP300_chr22_41546202_ENST00000263253_TNRC6B_chr22_40681649_ENST00000402203_length(transcript)=6075nt_BP=4036nt
CTTGTTTGTGTGCTAGGCTGGGGGGGAGAGAGGGCGAGAGAGAGCGGGCGAGAGTGGGCAAGCAGGACGCCGGGCTGAGTGCTAACTGCG
GGAGCCAGAGAGTGCGGAGGGGAGTCGGGTCGGAGAGAGGCGGCAGGGGCCGAGACAGTGGCAGGGGGCCCGGGGCGCACGGGCTGAGGC
GACCCCCAGCCCCCTCCCGTCCGCACACACCCCCACCGCGGTCCAGCAGCCGGGCCGGCGTCGACGCCTAGGGGGGACCATTACATAACC
CCGCGCCCCGCGGCGTCTTCTCCCGCCGCCGCGGGCGGCCCCGAACGGAGCCCCGGGGGGCGGGCGCTCCCAGCACCTGGCCGCCGGCGG
TGGGGGCCGTAGCAGCGGCCGTATTTATTTATTTTCCGCGGGAAAGGAAGGCGAAGGAGGGGAGCGCGGCGCGAGGAGGGGCCGCCTGCG
CCGCCGCCGGAGCGGGGCCTCCTCGGTGGGCTCCGCGTCGGCGCGGGCGTGCGGGCGGCGCTGCTCGGCCCGGCCCCCTCGGCCCTCTGG
TCCGGCCAGCTCCGCTCCCGGCGTCCTTGCCGCGCCTCCGCCGGCCGCCGCGCGATGTGAGGCGGCGGCGCCAGCCTGGCTCTCGGCTCG
GGCGAGTTCTCTGCGGCCATTAGGGGCCGGTGCGGCGGCGGCGGCGCGGAGCGCGGCGGCAGGAGGAGGGTTCGGAGGGTGGGGGCGCAG
GCCCGGGAGGGGGCACCGGGAGGAGGTGAGTGTCTCTTGTCGCCTCCTCCTCTCCCCCCTTTTCGCCCCCGCCTCCTTGTGGCGATGAGA
AGGAGGAGGACAGCGCCGAGGAGGAAGAGGTTGATGGCGGCGGCGGAGCTCCGAGAGACCTCGGCTGGGCAGGGGCCGGCCGTGGCGGGC
CGGGGACTGCGCCTCTAGAGCCGCGAGTTCTCGGGAATTCGCCGCAGCGGACGCGCTCGGCGAATTTGTGCTCTTGTGCCCTCCTCCGGG
CTTGGGCCCAGGCCCGGCCCCTCGCACTTGCCCTTACCTTTTCTATCGAGTCCGCATCCCTCTCCAGCCACTGCGACCCGGCGAAGAGAA
AAAGGAACTTCCCCCACCCCCTCGGGTGCCGTCGGAGCCCCCCAGCCCACCCCTGGGTGCGGCGCGGGGACCCCGGGCCGAAGAAGAGAT
TTCCTGAGGATTCTGGTTTTCCTCGCTTGTATCTCCGAAAGAATTAAAAATGGCCGAGAATGTGGTGGAACCGGGGCCGCCTTCAGCCAA
GCGGCCTAAACTCTCATCTCCGGCCCTCTCGGCGTCCGCCAGCGATGGCACAGATTTTGGCTCTCTATTTGACTTGGAGCACGACTTACC
AGATGAATTAATCAACTCTACAGAATTGGGACTAACCAATGGTGGTGATATTAATCAGCTTCAGACAAGTCTTGGCATGGTACAAGATGC
AGCTTCTAAACATAAACAGCTGTCAGAATTGCTGCGATCTGGTAGTTCCCCTAACCTCAATATGGGAGTTGGTGGCCCAGGTCAAGTCAT
GGCCAGCCAGGCCCAACAGAGCAGTCCTGGATTAGGTTTGATAAATAGCATGGTCAAAAGCCCAATGACACAGGCAGGCTTGACTTCTCC
CAACATGGGGATGGGCACTAGTGGACCAAATCAGGGTCCTACGCAGTCAACAGGTATGATGAACAGTCCAGTAAATCAGCCTGCCATGGG
AATGAACACAGGGATGAATGCGGGCATGAATCCTGGAATGTTGGCTGCAGGCAATGGACAAGGGATAATGCCTAATCAAGTCATGAACGG
TTCAATTGGAGCAGGCCGAGGGCGACAGAATATGCAGTACCCAAACCCAGGCATGGGAAGTGCTGGCAACTTACTGACTGAGCCTCTTCA
GCAGGGCTCTCCCCAGATGGGAGGACAAACAGGATTGAGAGGCCCCCAGCCTCTTAAGATGGGAATGATGAACAACCCCAATCCTTATGG
TTCACCATATACTCAGAATCCTGGACAGCAGATTGGAGCCAGTGGCCTTGGTCTCCAGATTCAGACAAAAACTGTACTATCAAATAACTT
ATCTCCATTTGCTATGGACAAAAAGGCAGTTCCTGGTGGAGGAATGCCCAACATGGGTCAACAGCCAGCCCCGCAGGTCCAGCAGCCAGG
CCTGGTGACTCCAGTTGCCCAAGGGATGGGTTCTGGAGCACATACAGCTGATCCAGAGAAGCGCAAGCTCATCCAGCAGCAGCTTGTTCT
CCTTTTGCATGCTCACAAGTGCCAGCGCCGGGAACAGGCCAATGGGGAAGTGAGGCAGTGCAACCTTCCCCACTGTCGCACAATGAAGAA
TGTCCTAAACCACATGACACACTGCCAGTCAGGCAAGTCTTGCCAAGTGGCACACTGTGCATCTTCTCGACAAATCATTTCACACTGGAA
GAATTGTACAAGACATGATTGTCCTGTGTGTCTCCCCCTCAAAAATGCTGGTGATAAGAGAAATCAACAGCCAATTTTGACTGGAGCACC
CGTTGGACTTGGAAATCCTAGCTCTCTAGGGGTGGGTCAACAGTCTGCCCCCAACCTAAGCACTGTTAGTCAGATTGATCCCAGCTCCAT
AGAAAGAGCCTATGCAGCTCTTGGACTACCCTATCAAGTAAATCAGATGCCGACACAACCCCAGGTGCAAGCAAAGAACCAGCAGAATCA
GCAGCCTGGGCAGTCTCCCCAAGGCATGCGGCCCATGAGCAACATGAGTGCTAGTCCTATGGGAGTAAATGGAGGTGTAGGAGTTCAAAC
GCCGAGTCTTCTTTCTGACTCAATGTTGCATTCAGCCATAAATTCTCAAAACCCAATGATGAGTGAAAATGCCAGTGTGCCCTCCCTGGG
TCCTATGCCAACAGCAGCTCAACCATCCACTACTGGAATTCGGAAACAGTGGCACGAAGATATTACTCAGGATCTTCGAAATCATCTTGT
TCACAAACTCGTCCAAGCCATATTTCCTACGCCGGATCCTGCTGCTTTAAAAGACAGACGGATGGAAAACCTAGTTGCATATGCTCGGAA
AGTTGAAGGGGACATGTATGAATCTGCAAACAATCGAGCGGAATACTACCACCTTCTAGCTGAGAAAATCTATAAGATCCAGAAAGAACT
AGAAGAAAAACGAAGGACCAGACTACAGAAGCAGAACATGCTACCAAATGCTGCAGGCATGGTTCCAGTTTCCATGAATCCAGGGCCTAA
CATGGGACAGCCGCAACCAGGAATGACTTCTAATGGCCCTCTACCTGACCCAAGTATGATCCGTGGCAGTGTGCCAAACCAGATGATGCC
TCGAATAACTCCACAATCTGGTTTGAATCAATTTGGCCAGATGAGCATGGCCCAGCCCCCTATTGTACCCCGGCAAACCCCTCCTCTTCA
GCACCATGGACAGTTGGCTCAACCTGGAGCTCTCAACCCGCCTATGGGCTATGGGCCTCGTATGCAACAGCCTTCCAACCAGGGCCAGTT
CCTTCCTCAGACTCAGTTCCCATCACAGGGAATGAATGTAACAAATATCCCTTTGGCTCCGTCCAGCGGTCAAGCTCCAGTGTCTCAAGC
ACAAATGTCTAGTTCTTCCTGCCCGGTGAACTCTCCTATAATGCCTCCAGGGTCTCAGGGGAGCCACATTCACTGTCCCCAGCTTCCTCA
ACCAGCTCTTCATCAGAATTCACCCTCGCCTGTACCTAGTCGTACCCCCACCCCTCACCATACTCCCCCAAGCATAGGGGCTCAGCAGCC
ACCAGCAACAACAATTCCAGCCCCTGTTCCTACACCTCCTGCCATGCCACCTGGGCCACAGTCCCAGGCTCTACATCCCCCTCCAAGGCA
GACACCTACACCACCAACAACACAACTTCCCCAACAAGTGCAGCCTTCACTTCCTGCTGCACCTTCTGCTGACCAGCCCCAGCAGCAGCC
TCGCTCACAGCAGAGCACAGCAGCGTCTGTTCCTACCCCAACAGCACCGCTGCTTCCTCCGCAGCCTGCAACTCCAGGCGGTAGTCATGG
TTTGTTTGGAAACAGCACAGCACAATCGAGAGGTCTGCACACACCCGTGCAGCCACTAAATTCTTCTCCCAGTCTCCGGGCGCAAGTGCC
TCCCCAGTTTATTTCCCCCCAGGTTTCTGCCTCAATGCTCAAGCAGTTTCCCAACAGTGGCCTGAGTCCAGGTCTTTTCAATGTGGGGCC
CCAGTTATCTCCTCAACAAATTGCCATGCTGAGCCAGCTTCCACAAATTCCCCAGTTTCAGTTGGCATGTCAGCTTCTCTTGCAGCAGCA
GCAACAGCAGCAGTTGTTACAGAACCAGAGAAAGATTTCTCAAGCTGTACGCCAACAGCAAGAGCAGCAGCTGGCTCGAATGGTGAGTGC
ACTGCAGCAGCAGCAGCAGCAGCAGCAGAGGCAGCCAGGCATGAAGCACTCGCCCTCTCATCCTGTTGGGCCCAAGCCGCATCTGGACAA
CATGGTACCCAACGCATTGAATGTGGGGCTCCCAGACCTTCAAACCAAAGGGCCAATACCTGGATATGGTTCTGGCTTCAGCTCTGGCGG
CATGGACTATGGCATGGTTGGTGGGAAGGAGGCTGGAACCGAGTCTCGCTTTAAACAGTGGACCTCCATGATGGAGGGGCTGCCCTCTGT
AGCCACACAGGAAGCCAATATGCACAAAAATGGCGCTATAGTGGCCCCTGGTAAAACCCGGGGAGGGTCACCGTACAACCAGTTTGATAT
CATCCCTGGTGACACACTGGGTGGCCATACGGGTCCTGCTGGTGATAGCTGGTTACCTGCCAAATCTCCACCAACAAATAAAATCGGAAG
TAAATCCAGCAATGCCAGTTGGCCTCCAGAATTCCAACCAGGAGTGCCATGGAAAGGTATCCAAAACATTGACCCTGAATCTGACCCCTA
TGTCACCCCAGGAAGTGTGCTGGGGGGTACAGCCACATCTCCCATTGTAGATACTGACCACCAACTGCTGCGGGATAACACCACAGGGTC
TAATTCTTCCCTCAACACCTCGCTGCCTTCACCTGGTGCCTGGCCCTACAGTGCCTCTGACAACTCCTTTACCAACGTTCATAGCACTTC
AGCAAAGTTCCCTGATTACAAATCAACATGGTCCCCAGATCCCATAGGACACAACCCCACTCATCTCTCCAACAAGATGTGGAAAAACCA
TATTTCCTCCAGGAACACTACACCGCTGCCCCGCCCACCTCCTGGTCTGACCAACCCCAAACCATCATCTCCCTGGAGCAGCACAGCACC
CCGATCAGTCAGGGGGTGGGGGACACAGGACTCACGGCTCGCCTCGGCCTCTACCTGGAGTGATGGTGGCTCAGTTCGTCCTAGTTACTG
GCTGGTTCTTCACAATCTCACCCCACAGATTGATGGGTCAACCTTGAGAACGATCTGCATGCAGCATGGCCCACTGCTGACATTCCATCT
GAATCTAACCCAGGGCACTGCCCTGATCCGATACAGCACCAAACAGGAGGCGGCCAAGGCCCAAACTGCACTGCACATGTGTGTGTTGGG
AAACACTACCATCCTTGCTGAGTTTGCCACTGATGATGAAGTCAGCCGCTTTCTGGCACAAGCTCAGCCCCCTACACCTGCAGCAACCCC
AAGTGCGCCAGCTGCGGGGTGGCAGTCGCTGGAGACCGGCCAGAACCAGTCAGATCCCGTGGGACCTGCTCTGAATCTTTTTGGTGGGTC
CACTGGGCTCGGGCAGTGGAGCAGCAGCGCTGGTGGCAGCAGCGGGGCCGATCTTGCTGGCGCTTCATTGTGGGGGCCCCCAAACTATTC
TTCTAGCTTATGGGGAGTCCCAACGGTGGAAGATCCCCATAGGATGGGCAGCCCTGCTCCTTTACTACCTGGTGACCTTCTGGGAGGAGG
GTCGGATTCAATCTGAACTTAGAACTTTCAACTCTGACCTCGTGACCTTTTTTGGAACAGCAGCAGCACTAACTTGACCTTTTCGTTTTT

>26760_26760_3_EP300-TNRC6B_EP300_chr22_41546202_ENST00000263253_TNRC6B_chr22_40681649_ENST00000402203_length(amino acids)=1578AA_BP=884
MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQTSLGMVQDAASKHKQLSELLRSGSS
PNLNMGVGGPGQVMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQPAMGMNTGMNAGMNPGMLAA
GNGQGIMPNQVMNGSIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKMGMMNNPNPYGSPYTQNPGQQIGASGL
GLQIQTKTVLSNNLSPFAMDKKAVPGGGMPNMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGE
VRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVGLGNPSSLGVGQQSA
PNLSTVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQSPQGMRPMSNMSASPMGVNGGVGVQTPSLLSDSMLHSAINSQ
NPMMSENASVPSLGPMPTAAQPSTTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYY
HLLAEKIYKIQKELEEKRRTRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPNQMMPRITPQSGLNQFGQMSM
AQPPIVPRQTPPLQHHGQLAQPGALNPPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNSPIMPP
GSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPS
LPAAPSADQPQQQPRSQQSTAASVPTPTAPLLPPQPATPGGSHGLFGNSTAQSRGLHTPVQPLNSSPSLRAQVPPQFISPQVSASMLKQF
PNSGLSPGLFNVGPQLSPQQIAMLSQLPQIPQFQLACQLLLQQQQQQQLLQNQRKISQAVRQQQEQQLARMVSALQQQQQQQQRQPGMKH
SPSHPVGPKPHLDNMVPNALNVGLPDLQTKGPIPGYGSGFSSGGMDYGMVGGKEAGTESRFKQWTSMMEGLPSVATQEANMHKNGAIVAP
GKTRGGSPYNQFDIIPGDTLGGHTGPAGDSWLPAKSPPTNKIGSKSSNASWPPEFQPGVPWKGIQNIDPESDPYVTPGSVLGGTATSPIV
DTDHQLLRDNTTGSNSSLNTSLPSPGAWPYSASDNSFTNVHSTSAKFPDYKSTWSPDPIGHNPTHLSNKMWKNHISSRNTTPLPRPPPGL
TNPKPSSPWSSTAPRSVRGWGTQDSRLASASTWSDGGSVRPSYWLVLHNLTPQIDGSTLRTICMQHGPLLTFHLNLTQGTALIRYSTKQE
AAKAQTALHMCVLGNTTILAEFATDDEVSRFLAQAQPPTPAATPSAPAAGWQSLETGQNQSDPVGPALNLFGGSTGLGQWSSSAGGSSGA

--------------------------------------------------------------
>26760_26760_4_EP300-TNRC6B_EP300_chr22_41546202_ENST00000263253_TNRC6B_chr22_40681649_ENST00000454349_length(transcript)=18522nt_BP=4036nt
CTTGTTTGTGTGCTAGGCTGGGGGGGAGAGAGGGCGAGAGAGAGCGGGCGAGAGTGGGCAAGCAGGACGCCGGGCTGAGTGCTAACTGCG
GGAGCCAGAGAGTGCGGAGGGGAGTCGGGTCGGAGAGAGGCGGCAGGGGCCGAGACAGTGGCAGGGGGCCCGGGGCGCACGGGCTGAGGC
GACCCCCAGCCCCCTCCCGTCCGCACACACCCCCACCGCGGTCCAGCAGCCGGGCCGGCGTCGACGCCTAGGGGGGACCATTACATAACC
CCGCGCCCCGCGGCGTCTTCTCCCGCCGCCGCGGGCGGCCCCGAACGGAGCCCCGGGGGGCGGGCGCTCCCAGCACCTGGCCGCCGGCGG
TGGGGGCCGTAGCAGCGGCCGTATTTATTTATTTTCCGCGGGAAAGGAAGGCGAAGGAGGGGAGCGCGGCGCGAGGAGGGGCCGCCTGCG
CCGCCGCCGGAGCGGGGCCTCCTCGGTGGGCTCCGCGTCGGCGCGGGCGTGCGGGCGGCGCTGCTCGGCCCGGCCCCCTCGGCCCTCTGG
TCCGGCCAGCTCCGCTCCCGGCGTCCTTGCCGCGCCTCCGCCGGCCGCCGCGCGATGTGAGGCGGCGGCGCCAGCCTGGCTCTCGGCTCG
GGCGAGTTCTCTGCGGCCATTAGGGGCCGGTGCGGCGGCGGCGGCGCGGAGCGCGGCGGCAGGAGGAGGGTTCGGAGGGTGGGGGCGCAG
GCCCGGGAGGGGGCACCGGGAGGAGGTGAGTGTCTCTTGTCGCCTCCTCCTCTCCCCCCTTTTCGCCCCCGCCTCCTTGTGGCGATGAGA
AGGAGGAGGACAGCGCCGAGGAGGAAGAGGTTGATGGCGGCGGCGGAGCTCCGAGAGACCTCGGCTGGGCAGGGGCCGGCCGTGGCGGGC
CGGGGACTGCGCCTCTAGAGCCGCGAGTTCTCGGGAATTCGCCGCAGCGGACGCGCTCGGCGAATTTGTGCTCTTGTGCCCTCCTCCGGG
CTTGGGCCCAGGCCCGGCCCCTCGCACTTGCCCTTACCTTTTCTATCGAGTCCGCATCCCTCTCCAGCCACTGCGACCCGGCGAAGAGAA
AAAGGAACTTCCCCCACCCCCTCGGGTGCCGTCGGAGCCCCCCAGCCCACCCCTGGGTGCGGCGCGGGGACCCCGGGCCGAAGAAGAGAT
TTCCTGAGGATTCTGGTTTTCCTCGCTTGTATCTCCGAAAGAATTAAAAATGGCCGAGAATGTGGTGGAACCGGGGCCGCCTTCAGCCAA
GCGGCCTAAACTCTCATCTCCGGCCCTCTCGGCGTCCGCCAGCGATGGCACAGATTTTGGCTCTCTATTTGACTTGGAGCACGACTTACC
AGATGAATTAATCAACTCTACAGAATTGGGACTAACCAATGGTGGTGATATTAATCAGCTTCAGACAAGTCTTGGCATGGTACAAGATGC
AGCTTCTAAACATAAACAGCTGTCAGAATTGCTGCGATCTGGTAGTTCCCCTAACCTCAATATGGGAGTTGGTGGCCCAGGTCAAGTCAT
GGCCAGCCAGGCCCAACAGAGCAGTCCTGGATTAGGTTTGATAAATAGCATGGTCAAAAGCCCAATGACACAGGCAGGCTTGACTTCTCC
CAACATGGGGATGGGCACTAGTGGACCAAATCAGGGTCCTACGCAGTCAACAGGTATGATGAACAGTCCAGTAAATCAGCCTGCCATGGG
AATGAACACAGGGATGAATGCGGGCATGAATCCTGGAATGTTGGCTGCAGGCAATGGACAAGGGATAATGCCTAATCAAGTCATGAACGG
TTCAATTGGAGCAGGCCGAGGGCGACAGAATATGCAGTACCCAAACCCAGGCATGGGAAGTGCTGGCAACTTACTGACTGAGCCTCTTCA
GCAGGGCTCTCCCCAGATGGGAGGACAAACAGGATTGAGAGGCCCCCAGCCTCTTAAGATGGGAATGATGAACAACCCCAATCCTTATGG
TTCACCATATACTCAGAATCCTGGACAGCAGATTGGAGCCAGTGGCCTTGGTCTCCAGATTCAGACAAAAACTGTACTATCAAATAACTT
ATCTCCATTTGCTATGGACAAAAAGGCAGTTCCTGGTGGAGGAATGCCCAACATGGGTCAACAGCCAGCCCCGCAGGTCCAGCAGCCAGG
CCTGGTGACTCCAGTTGCCCAAGGGATGGGTTCTGGAGCACATACAGCTGATCCAGAGAAGCGCAAGCTCATCCAGCAGCAGCTTGTTCT
CCTTTTGCATGCTCACAAGTGCCAGCGCCGGGAACAGGCCAATGGGGAAGTGAGGCAGTGCAACCTTCCCCACTGTCGCACAATGAAGAA
TGTCCTAAACCACATGACACACTGCCAGTCAGGCAAGTCTTGCCAAGTGGCACACTGTGCATCTTCTCGACAAATCATTTCACACTGGAA
GAATTGTACAAGACATGATTGTCCTGTGTGTCTCCCCCTCAAAAATGCTGGTGATAAGAGAAATCAACAGCCAATTTTGACTGGAGCACC
CGTTGGACTTGGAAATCCTAGCTCTCTAGGGGTGGGTCAACAGTCTGCCCCCAACCTAAGCACTGTTAGTCAGATTGATCCCAGCTCCAT
AGAAAGAGCCTATGCAGCTCTTGGACTACCCTATCAAGTAAATCAGATGCCGACACAACCCCAGGTGCAAGCAAAGAACCAGCAGAATCA
GCAGCCTGGGCAGTCTCCCCAAGGCATGCGGCCCATGAGCAACATGAGTGCTAGTCCTATGGGAGTAAATGGAGGTGTAGGAGTTCAAAC
GCCGAGTCTTCTTTCTGACTCAATGTTGCATTCAGCCATAAATTCTCAAAACCCAATGATGAGTGAAAATGCCAGTGTGCCCTCCCTGGG
TCCTATGCCAACAGCAGCTCAACCATCCACTACTGGAATTCGGAAACAGTGGCACGAAGATATTACTCAGGATCTTCGAAATCATCTTGT
TCACAAACTCGTCCAAGCCATATTTCCTACGCCGGATCCTGCTGCTTTAAAAGACAGACGGATGGAAAACCTAGTTGCATATGCTCGGAA
AGTTGAAGGGGACATGTATGAATCTGCAAACAATCGAGCGGAATACTACCACCTTCTAGCTGAGAAAATCTATAAGATCCAGAAAGAACT
AGAAGAAAAACGAAGGACCAGACTACAGAAGCAGAACATGCTACCAAATGCTGCAGGCATGGTTCCAGTTTCCATGAATCCAGGGCCTAA
CATGGGACAGCCGCAACCAGGAATGACTTCTAATGGCCCTCTACCTGACCCAAGTATGATCCGTGGCAGTGTGCCAAACCAGATGATGCC
TCGAATAACTCCACAATCTGGTTTGAATCAATTTGGCCAGATGAGCATGGCCCAGCCCCCTATTGTACCCCGGCAAACCCCTCCTCTTCA
GCACCATGGACAGTTGGCTCAACCTGGAGCTCTCAACCCGCCTATGGGCTATGGGCCTCGTATGCAACAGCCTTCCAACCAGGGCCAGTT
CCTTCCTCAGACTCAGTTCCCATCACAGGGAATGAATGTAACAAATATCCCTTTGGCTCCGTCCAGCGGTCAAGCTCCAGTGTCTCAAGC
ACAAATGTCTAGTTCTTCCTGCCCGGTGAACTCTCCTATAATGCCTCCAGGGTCTCAGGGGAGCCACATTCACTGTCCCCAGCTTCCTCA
ACCAGCTCTTCATCAGAATTCACCCTCGCCTGTACCTAGTCGTACCCCCACCCCTCACCATACTCCCCCAAGCATAGGGGCTCAGCAGCC
ACCAGCAACAACAATTCCAGCCCCTGTTCCTACACCTCCTGCCATGCCACCTGGGCCACAGTCCCAGGCTCTACATCCCCCTCCAAGGCA
GACACCTACACCACCAACAACACAACTTCCCCAACAAGTGCAGCCTTCACTTCCTGCTGCACCTTCTGCTGACCAGCCCCAGCAGCAGCC
TCGCTCACAGCAGAGCACAGCAGCGTCTGTTCCTACCCCAACAGCACCGCTGCTTCCTCCGCAGCCTGCAACTCCAGGCGGTAGTCATGG
TTTGTTTGGAAACAGCACAGCACAATCGAGAGGTCTGCACACACCCGTGCAGCCACTAAATTCTTCTCCCAGTCTCCGGGCGCAAGTGCC
TCCCCAGTTTATTTCCCCCCAGGTTTCTGCCTCAATGCTCAAGCAGTTTCCCAACAGTGGCCTGAGTCCAGGTCTTTTCAATGTGGGGCC
CCAGTTATCTCCTCAACAAATTGCCATGCTGAGCCAGCTTCCACAAATTCCCCAGTTTCAGTTGGCATGTCAGCTTCTCTTGCAGCAGCA
GCAACAGCAGCAGTTGTTACAGAACCAGAGAAAGATTTCTCAAGCTGTACGCCAACAGCAAGAGCAGCAGCTGGCTCGAATGGTGAGTGC
ACTGCAGCAGCAGCAGCAGCAGCAGCAGAGGCAGCCAGGCATGAAGCACTCGCCCTCTCATCCTGTTGGGCCCAAGCCGCATCTGGACAA
CATGGTACCCAACGCATTGAATGTGGGGCTCCCAGACCTTCAAACCAAAGGGCCAATACCTGGATATGGTTCTGGCTTCAGCTCTGGCGG
CATGGACTATGGCATGGTTGGTGGGAAGGAGGCTGGAACCGAGTCTCGCTTTAAACAGTGGACCTCCATGATGGAGGGGCTGCCCTCTGT
AGCCACACAGGAAGCCAATATGCACAAAAATGGCGCTATAGTGGCCCCTGGTAAAACCCGGGGAGGGTCACCGTACAACCAGTTTGATAT
CATCCCTGGTGACACACTGGGTGGCCATACGGGTCCTGCTGGTGATAGCTGGTTACCTGCCAAATCTCCACCAACAAATAAAATCGGAAG
TAAATCCAGCAATGCCAGTTGGCCTCCAGAATTCCAACCAGGAGTGCCATGGAAAGGTATCCAAAACATTGACCCTGAATCTGACCCCTA
TGTCACCCCAGGAAGTGTGCTGGGGGGTACAGCCACATCTCCCATTGTAGATACTGACCACCAACTGCTGCGGGATAACACCACAGGGTC
TAATTCTTCCCTCAACACCTCGCTGCCTTCACCTGGTGCCTGGCCCTACAGTGCCTCTGACAACTCCTTTACCAACGTTCATAGCACTTC
AGCAAAGTTCCCTGATTACAAATCAACATGGTCCCCAGATCCCATAGGACACAACCCCACTCATCTCTCCAACAAGATGTGGAAAAACCA
TATTTCCTCCAGGAACACTACACCGCTGCCCCGCCCACCTCCTGGTCTGACCAACCCCAAACCATCATCTCCCTGGAGCAGCACAGCACC
CCGATCAGTCAGGGGGTGGGGGACACAGGACTCACGGCTCGCCTCGGCCTCTACCTGGAGTGATGGTGGCTCAGTTCGTCCTAGTTACTG
GCTGGTTCTTCACAATCTCACCCCACAGATTGATGGGTCAACCTTGAGAACGATCTGCATGCAGCATGGCCCACTGCTGACATTCCATCT
GAATCTAACCCAGGGCACTGCCCTGATCCGATACAGCACCAAACAGGAGGCGGCCAAGGCCCAAACTGCACTGCACATGTGTGTGTTGGG
AAACACTACCATCCTTGCTGAGTTTGCCACTGATGATGAAGTCAGCCGCTTTCTGGCACAAGCTCAGCCCCCTACACCTGCAGCAACCCC
AAGTGCGCCAGCTGCGGGGTGGCAGTCGCTGGAGACCGGCCAGAACCAGTCAGATCCCGTGGGACCTGCTCTGAATCTTTTTGGTGGGTC
CACTGGGCTCGGGCAGTGGAGCAGCAGCGCTGGTGGCAGCAGCGGGGCCGATCTTGCTGGCGCTTCATTGTGGGGGCCCCCAAACTATTC
TTCTAGCTTATGGGGAGTCCCAACGGTGGAAGATCCCCATAGGATGGGCAGCCCTGCTCCTTTACTACCTGGTGACCTTCTGGGAGGAGG
GTCGGATTCAATCTGAACTTAGAACTTTCAACTCTGACCTCGTGACCTTTTTTGGAACAGCAGCAGCACTAACTTGACCTTTTCGTTTTT
TTTTTCAACTTGCAATAAATACATTTTTAAAAGGAAAAAAGAAAACGGAGAGAAAAAAAGGTGGGTCATTGACAGACTGTCTGAGCACAT
AGTTGCCTCCCTTATAACTTCAGTTTTTTCGTTTGGAATATGAATCCAAAAAGAGAACATATCACTCTTGAAATACTTGAATCATGAACG
CCAACCTAGAAAGACAATGTGAAGCAAGTACACATACCATTTAAATTTAAACACAAAAAAATTAAAAAAATTAGTTTCTAGTTTTTCACT
TTTTTCATGTTATATGGAAGTTGTTGCTAAGAAACATATATACTGAAAAAAAATAGCTTTTTAACTTTGTTTGCACTGGGTGTGTTTCCG
TCCTTAGGTCTACCATGTTTGGGAGGGAGGGAAATTCAAAAGAATTGTTGGGGGAGGGGGGAGGGAAGACTTGACGGAGCCTCACTTTAA
AAACAAAAACACAAAAAACCTAAAAAAAAAAAAAAGGAAAAAATTTGTGATTGGCTGGTTGATAAATACCAGTGTGTTCTGGCACATGTA
ACTGCCCAGGCATGCTCGTTCTGGTGTGTGTGTGCACGTGTGTTCATGTGCATTCGCGTGCATCCTTCTCTGTCTCTGTGTGTGTGCCTG
TGTTCTTCCCTTCTCCCCTGCCCCACCCTGACTTCTCAGAAAGCTGCATCGCTGACAGTCTGCAGGCTGGCTGGCCGGCCCATCTGCTTT
TTATTTTATTTTTTTAACTATGAGAACACACAGGCCCGGAGAGCCACTGCTACTAAAGCAACTCCATTGGGCTGCATTAAGATGAACAGA
GTGCTTTTTAATGATGAAAGCAGGGAGCTCCTTTCCATTTGCAACTTAGCCTGAATGTGGGGTTTCTCTGGCTGTTCTTTTGACCTAGCA
GTAGAGTGGAGCACTGCCAAGTCCAAAAAACTAGAGCAGGAGGTACCTCTTGGAGCAACGGTGTGTTTATTTCTGTTTTTTTTTTTTTTT
AAGTGAATGGCCACCAGGCACATCTGAGTATCTGTTAAGTTTCATGCAGGCCTTTTCGTTAGTTTGAAATGGGAACGGAAGATAACTTTT
GATGATGCGATGTCTCAAAAACAGAGAAACTTTGTTCCCTCTTTCCTTATGATCAGGTTTGAGAAATTCTTCAAAAAATTAGGTGAAGTT
GAGTTACATATTTCTGTTGGTTGGTTCTCTTTTTCATTTTATGAAAACAGAAAAGAATAAGTGGTGAGCAGCCTCCTGAAAGCATCTGCA
GCTACTCCCTCTGCTCCTTTCTCGCCGAGCGTTACCTGTGCCAGGCCGTGGCGCGTTACAGCACCAGGCCATCACTGACAGAAACGTTTA
CTTAACGAATGTTCTTAAACCAGTGTGTACTTCAAGCGTTTCCTTTTGTTTCTCTGTGTTGTGTATTTCCTGTGTATGTGGTTTTGCTTA
GGCAGGTATAACTTAGCGAAGACTTTTAAGTATTGCACCTTTTTTTGATTTTTGACCTCTTCCCCCCACCTTGTAATTTTGCTTTTTTAA
TTTCGGTATTTAAATACTTTTTTTTTTTTTTAAGCATCAATGTAGTAGTACTCTGGGCCGAACAGGGGTCAACGTTTAATCTACAGTTAT
CACCAACATGTATGTACTTATGTCGGAATCAAAATGTATCAAACTGCTTATTGTGAAGAGAATTATAGCAGACCTGAAGGGGGCGAAAAA
CCAGATAGGGTGGGGGGATGGATGCCGGTGACGTGCTAGCACTTGTGTGGACATCCCAGTCTGCATTATGCTGTTTAACATAAAGTGCCG
ACATTTTGTACCAGCAAATACCTGCCCATTCCAACCCTTGGTGGGAGCAGACCTCTACTGTCCTCTGTAACTTGCTGCTATTGAGGACAA
GGGAGTTTTTCTTTCTTTAGCGTCTTCAGTGAAGGATACAATACAACAATGCCTAATGTATTTGACTTTTTAGCTTGTGTCTGTGTGTAG
GTGGGTGGGTGGGTGTGTATAGGAAAAGCCTAAAACAAGTTATTTGCATTTCAGTGGTTTTGTGAGACAAAGAATGGGAAATTCTGTAGC
CCTTCTGGCTTACCCTGTTGATTATAAACCTAGCCTCAAAAGAGATTGACAGGCATGACTCAAGTGAGTGTTCACATATACAAGCCTGCA
TGAGCCCTCTGTGGGTAGGTGGTCACACTTGGCATCTGCAGCATTGACGTGGCCCCGCTGGGTGCCTTGAGCATGCCCTCTTCCTGCTCT
GCAATTTGAATCACCACCGTGCCCCTTCCACCACTGTTCCCCATGCAAAAGCTCTGCTTCCAGCAGCCCCCACTGACCGCTCTCTGTGTG
GAGCAAAGTGCTGTCGTGCGGTGACCACCAGGTGAAGAGCAGCTTGTATTCAGACATCTAGAGAAGGTTAAATCTTAGTGTCCCTGGGCC
AGGAGCATATCCCAAGGCTCCTGCGAGCCAGTGGCGACCCTGTCCACTGCCGCTCTTGGTTCACTGCTGTGTCCTGCCCCACCCTCCTCT
CCTCCTGCCTGTTGGTTCCTTGACCTGCACTATGGGTTAGTTGAGTTCCTTACGATACTACGGTGAAAGCCGGGTGCTAGAGCCCCTCTT
GTTTACAAGACATAATGAGGGATTTGAAATATGTAAAAATAAACATGAGAAGCTAAAATGTTCTTCCATCATAAGCTTAAAGGGAAAAAA
ACTAAAAACTTTAAAAAAAAAAGACCAAAAAGTGCGTATATATATACATATAAATATATATTTTAGATGAAGACTAACTCTGGGAGCATT
TAACAGTGTTTTTTGTTTCTGTTTTTAACATTTGTTTTCCTGCTTTAAAATTTGCAAGCATTCTCAGGAATTCTAGGGTAGGAAGCCAGT
TTTTTGAAGATGGTTTATTTAACCATATCTTATCCTAGAGAGATGGCTGTTTCTTTCCTGTTAATAAACTTTTACAAGTTCCTGAAACTT
CAGAAAGTTTAAACAATTTTTACTTAAAAAAATGTAAAAAGAAAAGTCTCCAAACATTATTGTCATACTGGGGATCACACATTTTAAAAC
ACATAGAAATATTTTTTAAAAATTATCAATTTAGCAGCAACAGGTAAATTCATTATCTTAAAAATATGGGAGAAGGATTAAGCTTTGTAA
GAGCTCGATCATGGATTCTTTTGAAATTGTGTGTAGTTTAATGGGAGAGTGTTTGGTGTATATAGATGAGAATGCCATCACTTTGTTCCT
TTCCATTTGAGACTGAACTGAAATCTCCCCTAGTAATTTTTATTTTTTTAAAGGAACCCTTCTCCTTGTCCCCACAACCCCAGCAACAAA
AGAAAGGAAGGAAGGAAGAAACAACAGCTTAAAAAAAAAAGTAATCTGTAAAATAGTACAGTTGGATTGCTGAGAATCTATGTAAAGAGT
TAGGAAATATAGGTTAATAATTTTTGGAACAAATTTTAAATATAGGCATTACTAGAGGAAAATTATCTATGGACTGTCCTATTAATGAAG
AATGTCTGTCTTACCTCCGTTTGTTTTGGGAGGAGGAGAAAATATAGAAGAATCTAATAAGGAACAAGTGATTTTACTTTTTTAGCTCCC
AGCTACTGTTGTGCTCGTTTTAATTGCTGTTTTGAAGATCTGCTGCTTAATTATCCCCATCCCTTAGCCGGAGATGTGGAGTGTTTCCTT
TCAGTTTTTGGTGATGTTGAATTCTTTTGTATTCCCTCCTGGGGCCAGGGGTCAGAATTCCCAAGCATGACCACAGCTTCTTTTAAACAT
TAAGCTTCCCAGTGGGAAGGAAACTCCAGCTCGACAGGTAAAGGGAGTGGGTGGGGTTGCTGCCTGCAATTTCTCTAAAACCGCTTTAGT
GCCTTCGTACATACACCCAGACATCCTGAGCAAGGGGGACGCACATGTGTGTGTGTGTGGTCCAGTCACTCCACAGATGTAAGATACTCA
CCCATAAAGGAAATTGGAGTGGTTCTGGACAGGCCCCAAAGGCAGTGGGCTGAATTTAAAATAAATAAACAAACGTCAAGCAAGTTAATA
TGCTTATGTCTCAGTAATGTAGAATGCCAAGTTCCTTCCTGTGTCGTGTGCCCTCCATTACTGTGCATTGATTCCTCCAGGTGTGTAATT
GTGACAACTGCAGTGATTTGGAAAGTCTCTTTGTCTTGGGCAAATAGAAGGGGTTCCTGTTGTTCTGCTCTTGTCCTTCGTCTCCTCCCC
TTTTCCCCCAGACCTCCCCCTTCTTTTTGTCAACTTGCTGGGAGCTTTGCTTTATTGGTTGGCAGTGACCTAAGAACAGGATATGGTGAG
GATGTCATGGAAGAGAAGAGCTCTTTCCGTGGTATTCTTTGGCAAGAGCCATGTCTACTAAGAGGTTAGATGACTTCAGTATACTTATAA
AATTCAGTGAGAGTGCCTTCTTCTCTTCTACCACACTCTGGCATAGATACAGGCTTGCTGGTCACCTCTCATTACATAGATTTATTTTAA
AAACATTTTGATTATGTTAATTTGAGCTTTCCCTTTTTTTTTTTTAACTACTTTTTAAAACACTTGATTACTAGTGGCTTAGAGGTGTGT
ACATCTCCTGAACATCACAAACTTGGTTTCTACCTACCACACGAGTAGCCAAAAGAAAAGAAGCACTAATAGAGAAAGGGGTGTCTCACA
CCAGACAGAGGACCTCTGCTGTCAATTAGATCCAGTATCATGACCTAACTTTAAGTGTGGAAAAGAGTTCAGATCTCTGAGACACTGTGA
AGAAATGGATGGCTCATGTAACATCTCTGATCCCTCAGTCCCCAACCCTGGACGTGTTTCATTTACAACATTCATAGGAGTTAACTTAGC
AGTGTTGCAAGTTAAGGTTCCAAACCAAATTATTTAATCAGTGTCCCCCCAATAAATCACTTATCCATTTATTGCTAGTTAGTTTTATTT
ATAGCAACTTGATTTCCTATGAGTATGGCTCCTGTTGTAAGAATTTTCCCACCTCTTCTGACATGAATGTAGCATAAGTTAGCAATCGGT
TCTTCCAAACTCCTGTGGGTTGAATATGGTATAGAAGGTATGCAAGAGGAAAAAGAAAGGAAAAGATAAAACTCCTGCCTGAGAATTTGG
AAGCACCTTTATTAACACATATATCTCGCAGAAACTAGAAGCTCATAGGCTGTTAACTTTTTGCAACTATTCACTCATTTTTACCACTTT
TTTTTTTGGGTGAGGGGGTGATTTTTGTAAGGTTAACAGCCAGATTCCATTTTGACCTCAGATGCTGTGTACTTTTTAATTTCATTTTTT
ATATTCTGCCATCTTGACTCTTCTCTAAAACAGAATGAAAATGTCTGCATGCTGAGCAAAATGCTTACGCCAAGCCTGTTTTTCTCTGCA
GAGTAAACAGGATGTTTTCAGCAGACTTGGCTCTAATAGCCATCTCTAAGATTAGGGAACAATTGAGTCTTTATGTAGAAAAGATCCATT
TTTTCCCCATCCTCAGAGTTAAAATTCAACATTTAAAGCTTTATCGGTTATTGTTTTAGATTTGAGATTTTTGTTTTTAAGTATCTATAA
GATCTTTAGAAGTGAGATAAATTTTTCGCTGGTTAAAAAAAATCAAACTTTCCTCTGCAGTGTTTTTGCCAAGTTTTGTCACACTTCATG
TGTATGCATTAACTATACTTCTTAGTGTTACTGCAAAAAAAAAAAACAAAAACAAAACAAAAAAAAGCCTTGTTCTTTAATTGTGTTTTT
CCTCCTGTGAGTGGACAACTAAAGCCGCGTGATGATGCGGATGAAAATATTCTGGTCTGTGTGTATACAATGAATTGTCAGTCTTCAGAC
CTCATGGTCGTTAAGAAAATAGGGAACTCACAAACCCTGCTGCGCACTACATTTACTTCTTTATCTGCAAGTACAGGGAGTCCATACAGT
CAAGAAACACACAGATACACATAATGCTATTGAGGACATTGTCATTCTGTAAGAAAACAGAATATTATCTAGATTTCCAGAGTTAGTGCA
GACCCTGTGATAACAGTCTGTGGGTTTGTGGCCAGCGCCAAAGGTGTGTGTATTTTCAGAAATGGTCCCTATTTGTCAGTGATAGTGTTT
TTTTTTTCTTAAGTTTGACAAAGGGGGTGGTAATATCACATTCTTTAGATTTGAAATAATTATCAGCTCCAAGAATCTGTGAACATAGTA
ATAACAATAAAAATTCAACATCGACCCTCCCTAACCTGCTCACCATACCTCCCCACCCCATGCCTCTGAAGAAAGAGGCCATGAACCTAC
GAGGTGGTAAAGGGGGACACAGGTCAGGGAGTGGAGAGCTACTCCTCCAGCAGCTCAGCACCCACACTGCCCGCATGCGTGTGGCCACCG
GGACCAGATCCCGAGTGATTGTGGCATACCCCTAATATTTGAGTAGTTTTTAAGCTGTCAGTCTCTTGTCATAACCTCCTACCGCCACCC
AAAAAAGTAACGAAAGTTGCAGTAACTGCCAGTGTTTGCCTCACCAAATTTAAATCGTTCCCTTTTCAGTTAGCTATATACCTGAATTTG
TTTTTAACAAGAAACTGTACATGGCCAGGAAAAATGGTACTACCTTGGCCAAAGGGTCTTTGCAAAAAGCTCAGTCTTCAGTTCTTCACT
GTGACAAATGCTTATCTTGTTCATGGGAGGGGAAAGATCAGATAAATAGGCAAGAAGTACTCTGTTTTAAATAAAGAATAAATAGTGTCC
GTTTAAAGCACTTTGTGCCTCAACTTCATTTTTAAACTGTAAATCATTGCTTTGGAAATAAATTCCCAATTATAATTGACCCATATCTAG
CCAATATCAACAAGTTGGGATGGTTTTTGTTTTTTTCTTTTTTTTCAAAAAGGGAAATTCCTCTTTACTGCTCACAGTAAGCTGCAAAAG
AAAGTTGTCAAGGTGGCTTATGATGCTGTTGTAGCAGAGCTGTGAAAGGAAGTGCTTTGCTTTCTCTCCCGCCTTCCGGAATCTGGCGTT
CCTTCCCCTTCGGCTACTGAAAGGTGTGTACAACTCCCAGAGGGGTGGCTGTAAAAGTTGACTGGAGGCAAAGTGGAGTGGCCTTATTGC
CAGGACTAGCCCTACAGAAGAGCTTTACAGAGAGGAGGACAGTACATCCTATGTGTGTTCGCCAAAAATGGGAAAGGTGGGTATTTAGGC
AAAACAAAATAAAAACCTTTGGAACCCTTTAAGAAGTTACATACCTTTTAAAGGTAGTATAGTTTCTCACCAAGTGATGCATTTTAGCAT
GACACTTCTTGCCAGAAATTTTGGGATAAGTTGGAATAAATGTGTTTAAAACATCATCCACCGCCCTTTTTAAATTTTGTCTAAGGAATT
ACTTAAGTATAGTATTTCTGAATGTGCCTTTGTGAGTACAGAGACCGTCCGTTCTAGGAAGAAGCTATCCGTTGGATACAAACAAACAGA
CGGTCAGCTTTAGTCATTAGGGAAGTCAAAGTTCCTCCTGGAAGTCCCAGGAGCAGCTGTTGAGATTTCATTAGCATCAATATTGCACAG
TGTAGAGTTGAGTGGAAGAGATTCTGGGACTTGGGAGAGGAGACAGGGGAAGGTACCCAGGCGACGCAGACCCACGTTAGTCCAAGAGCG
CAGGTTTACACATCTGCATTCCCTAGTTTTCTCCGTCTGTATGTTTGTGCTCATGTGGCTTTGGCTGTTTTGTTTTTTGTTTTTCTGTAA
GCACTGGAGAATTGGAATATGGTGATACTTGTGACACATTCATGCATGTAAACAAGGCATTTTCCAGCTTCTGCCGTGTGCAGAGCGGGC
AGCACGCTTTTACCCTTTGAGTCTGTGTCCTGAGGCGGCCATTACATTCCCACATGGGCGTCACATCACGTTGCTGTTGATGCAAACAGG
GTATTACACACAAGGAAAAGGGGTTTTGAAGAGTTAAGATTGAAGTGTTTGAGAAAGAAAAGAGAAAAATCTGAAATCATATTTTATTTC
TTCAGAGCTATTATAGTTGAACACAGAAATCTGCAGTGTCTTTATTTGTTTTTATGTTTTAAACAATTTCACCTCTTCTCCCCACTCCTA
TCTTCTAAAGAAATATCAAGCAAATGCTAAGGGCCATTTCCATGATTCCTCAGAGCTCCCCCAAAGAGGAGAACAGTCCCTCCCACTCGA
TTCCTTCAGCTTCATTCAGGAAGACACAGGGAGGAGAGATGCTGCTTCTGCGCTTTGCTCTCATTCCTCTCTCATGGCCTTGAAATGTAT
TATTATGCAAATGTGAATTTTGATACTGAATTTAAGAAGAGGTTGTTGGATTTTTTTTTTTTTTTTTTTTTTTTTCAAAAAAAAAAGTCC
CACATGTGGTCATCGTCGCTTCTTTATGTTGTAAGGTGAATTGTAACTATGCATTCTGCAAAGGGGGTGGGGAGGAGAGGGCAGAAAGGG
GAAGGGAGTAGCGTTGCATCCTTGTTCTTCAGTTTCTGTGTCCATGGTGTCCCCGTGTCCTGGAGGGGAAGGGGAGTGAGAGACGAATGT
GGTAAGGTCAGCACAGTGAGATAGAGACCTCTGAGTCCTCTTGCCACTGTTGCTGGCAGGTCTGATGGCCAGGTAAATTCCAGGGGGCCT
GCAGTTCCTGTCAACCAATGTGGTTCAGGATTCTTGATCCTAGCCGTGCAGTGTTAATCCAGTGCAGCAATGGAACTCCACAGGCTCCAG
TGTTCTCTGGAAAAAGTACTCATCCTTTCCTGAATTCAGAGCCCTTCAAGCTCAGGAAACCACGCTTCACTCGTGCTGACCTGAAAGTTA
ATCTTTAGGTCGATTTTGAAAAACTCCGCCTCCTCTCTCCTTTTTAATATTTCTTTCTTCCTTTTTAATCATGTTTAAGTGAACTTACTC
TTAGTTATAAGGAACTGTCCTGCTTTGTGGGGAAGAGGGCTGTTGCTTGTCAGGCAAAAAAGTTTTCTCTTCCTACCCACCATCCCTCTC
TCTGCTTCCCTTGCATTTGGCAGGCTGTATGAAGCCAATGAGCTGCGAGGTGTTTTGACAGGGGAGGTCTGCATGCAGCCTCTTCTTTGT
CCTAACAATTCCTTTGTTGATCTTGCCTGTGATGAATCATAGCGCCTGCATTGCTCTGGTCTAGGCATTATTTGCAACACACAGTATCGT
AAGCGAGAGATTGTTCTGCCTATATTCAGTGTTTTCCATGCAGCAATTCTTCTTGTTGACGTTCACAGTACTGTAACGAGTAACAGACTT
GATCACAGTCTCCTCGTGCCTGTGCAGGGCTGCACAGGCATGATCTTATCAGGGTTCCAATCTGTTAGATTGCCTTTAAACAAAAAAAAC
AACAAAAAAATAAAATCCTGACGTTTCAACTGTCTCACACAAAATAATACCTCGAGGTACATTTCCCCCTGCAATGTAAACCCTTAACTC
CTCTCTCCTTTCTGACATCAGTGGATTATCCTTTTTAAAATATGAACATGTAAATAGCAGGATAACTTTAAAAAACATTTTCTTTGCTGT
GAAAGTAACCCTAAAATATGTTTTCTTCTTTTGTATTTTTTTGGTTTTTGTTTTTAAGCCATCAGAAGTTTCAGATCTTTACTCTTTCAT
GTTTAAGAAGAAAGAGCAGAGGAGGTCGGGGGAGCCGGTTTGCATTTGTGTTGGAGGGGTGTTATCTCCATTGCCTCCCACACAGTGACA
GCAGACCAGTATGTAAACCCTGTCTTGGCTGGGCGCGGTGGCTCACACCAGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCAT
CTGAGGTCAGGAGTTTAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAAATTAGCCGGACGCAGTGGCGCGCGCCTGT
GGTCCCAGCTGCTCGGGAGGCTAAGGCAGGAGAATTGCTTGAACCCGGGAGACGGAGGTTGCGGTGAGCCGAGATTGCACCACTGCACTC
CAGTGTGGGCAACAGAGCAAGACTTCGACTCAAAAACATAAAATAAACAAAAGACACACACACACACAAAAACCCTGTCTTAAATAGCTG
CCATCTCTTCCAGCAATCTAGTGCCAGGGTAAGAAGTGTCTGAATTTCTCTCTTCCAGCAGATCCATCCCCTGCAGGGACTCCAGAATGT
TCTCCACACAATACCTGGAGCTCTCAACCTTTCTTGGTTCAGACACACACATACACACCCCTTGAGTAACTCAGTATCATTTTGTAGTTC
ACAGAAGGATGTAGTCCCTGGCATTTTGGTTTGCACTGTAGAATCCATAGCCTTGTCACTTTGTTATGCTCTGGAAATGTACTGATTTCT
TACTTGGGAGGAAACTTGTGTAAGGAGATGTGCAAACCACCCTGAAAGCCATGTGCATCCTCACCTCTTCCATTACCCCCTCCATGAGCT
CGAAGCGACATTAAGTAGAGGGAAATGCTTTTAACAAATGCTGCTCATGTGGATCTGTCAGCTATTGCTTGCCTAGATTTGGGCACCCAT
GAAGCAGGGTTGGAATGGATCATTTTGAATTGCTTCTTTGCAGACACCCCCTTCGCCCCCATCTTTAAGATAAACCCTTTACTAGTCAAG
AAGCCCTTTTCAGTTGGATCTCACTGATCTTGTATAGTGACGACTTCCTTTGAAGGAAGAAGCTTGATTATAAGTGCATGCATATTATCC
ACCCACCTTCTGATTTGGGCACTGTTCACCTTGGAATTTTATTTATTTTGTTTATCTGGAGGCCCTTTTTCTATCAGTCTCTGATCCCTC
ATGGGTTCTGCCTGCCCTTGTATCTCTTGTACAATGCTCCCAAAGGGCTTTGCTGATCTCTGCACTTCTTTCCTGGGACACTCCCCCCAC
CACCACCCTTTGCACACACCAGTGACCAAAGTGTATGCAGTGATCTCACAGAAGACATCAAAAATGGTGCATGCACCGTGAATGTGCTCA
CAGAGACACGTGCACAAGATTCTGCACCCTTGGCCTTAATCTCAGTATGACTTAAGGTGCAGGAACATTTTTAACAGGTTTTAAAAAAAC
AAAAAACCCTTCTGGGAGGAAAAAAATAAAAAGCAGATACAACAGCTCAACTGTTCCCACTCCTAACTCTCCACTATGTGCTTATAACTT
CACATTCTATGCCCTCCCCGCCACCCACCTCATCCCTGTTCTGCGTAACCAAAAAACAGACAACAAAAGCAACCTGAGGAGAGGTTTCTG
GACTATTTTATCTGTCTCCATTTAGATGGAGATATAAATGCTGCTTTGGGTTCCATAATCCTAGGGGGCTATGTTTACATAGTAAAATAC
ATCCTACCAAATCAGGAAACAGTGAATAATGGGAGTCACTTCACAGAGACGCAGGAGGACCTGGGGGGCGTAGCAGAGGAGGATAGGTAG
AGAAGTACCATTTTAATTATTTGTGACTTGTGGCTTCCTTCCTCCTCTCCTCCTCCCTCCACGTCTCTCTTTGCCCCCTTTAGACAGAAG
GTGCAGAAAAGGGCATCAAAAAGAGGCTGGATTTTTTAAAAGGCAGCTTTCCAACTTTGCACACAAACAGGTAACAGGAAGGTACAGCAA
AAATCCTCTCATCTGAAACACTGTCAGCAGAAACAAAACCTGTAAAAATGACTAATCAGCTGCACATATTGATGCTCTCTGCAAGTTACC
TTTAAGTGTTTTTTTTTTCTTATACTTGAAGTTGCTTTTACGATATTATTTTGGTGGCTTTCTTTTCTCTCTTTGATGGGCAATAGAGGA
AGTAGATAATGGGATTTAAGGACGCCTGGGGGAGAAAAGGGAGGATGTGGCATTGTCTTTTTTTTTTTTTTTTTTTTTTTTTTTAGCATA
GAGGTTTAATCAAACTCCCATATGTTGAAATTGCTCCTCATATTACTGGTTTTACATGGACACAGAAACTAGGCACTTTAGAGGTGCACT
TGCATGGCAGGCTGGGCCCCCTTTTCTATATTTTATTTTCCTTTTTAGTATAGTGGTACTTAAAATCACTGGTTCACTTAAAAAAACAAA
CAATAAAATGTTAAACTCTACTAATGTACAAATAAGCTGAAAAGTTGCATTTTATGTGTATTTTTTGCCATAGCAGGTACTGTATTTCTC
ATGCTGGATTTCAAAAAAAAAAAAAAAAGTATCAAAAACAAAAAAAACTAAAGGGTGGTGTTTTATTGGATTGTGACAGGTTGAGTAATA
AGGAATTAAGTCGTCGTCATTTCATTAAAACTGAGAGATGATGTAATGCATATATAAGAGTTTTCTGAAGGGTTTTTTTTGGGCTTTTAA
ACAGCTTATTTTTGTTTTTGTTTAGTTTTTTTATTTTATTTTATTTTGGAAAGATATGATTGTATTATGTGCAACTCAGTTGCTTACATT

>26760_26760_4_EP300-TNRC6B_EP300_chr22_41546202_ENST00000263253_TNRC6B_chr22_40681649_ENST00000454349_length(amino acids)=1578AA_BP=884
MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQTSLGMVQDAASKHKQLSELLRSGSS
PNLNMGVGGPGQVMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQPAMGMNTGMNAGMNPGMLAA
GNGQGIMPNQVMNGSIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKMGMMNNPNPYGSPYTQNPGQQIGASGL
GLQIQTKTVLSNNLSPFAMDKKAVPGGGMPNMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGE
VRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVGLGNPSSLGVGQQSA
PNLSTVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQSPQGMRPMSNMSASPMGVNGGVGVQTPSLLSDSMLHSAINSQ
NPMMSENASVPSLGPMPTAAQPSTTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYY
HLLAEKIYKIQKELEEKRRTRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPNQMMPRITPQSGLNQFGQMSM
AQPPIVPRQTPPLQHHGQLAQPGALNPPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNSPIMPP
GSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPS
LPAAPSADQPQQQPRSQQSTAASVPTPTAPLLPPQPATPGGSHGLFGNSTAQSRGLHTPVQPLNSSPSLRAQVPPQFISPQVSASMLKQF
PNSGLSPGLFNVGPQLSPQQIAMLSQLPQIPQFQLACQLLLQQQQQQQLLQNQRKISQAVRQQQEQQLARMVSALQQQQQQQQRQPGMKH
SPSHPVGPKPHLDNMVPNALNVGLPDLQTKGPIPGYGSGFSSGGMDYGMVGGKEAGTESRFKQWTSMMEGLPSVATQEANMHKNGAIVAP
GKTRGGSPYNQFDIIPGDTLGGHTGPAGDSWLPAKSPPTNKIGSKSSNASWPPEFQPGVPWKGIQNIDPESDPYVTPGSVLGGTATSPIV
DTDHQLLRDNTTGSNSSLNTSLPSPGAWPYSASDNSFTNVHSTSAKFPDYKSTWSPDPIGHNPTHLSNKMWKNHISSRNTTPLPRPPPGL
TNPKPSSPWSSTAPRSVRGWGTQDSRLASASTWSDGGSVRPSYWLVLHNLTPQIDGSTLRTICMQHGPLLTFHLNLTQGTALIRYSTKQE
AAKAQTALHMCVLGNTTILAEFATDDEVSRFLAQAQPPTPAATPSAPAAGWQSLETGQNQSDPVGPALNLFGGSTGLGQWSSSAGGSSGA

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Fusion Gene PPI Analysis for EP300-TNRC6B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-14312_139939.02415.0ALX1
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-14312_149939.02415.0RORA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-14311397_1399939.02415.0histone
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-14312003_2212939.02415.0HTLV-1 Tax
HgeneEP300chr22:41546202chr22:40681649ENST00000263253-14312041_2240939.02415.0NCOA2
TgeneTNRC6Bchr22:41546202chr22:40681649ENST0000030192311241_994390.01030.0argonaute proteins
TgeneTNRC6Bchr22:41546202chr22:40681649ENST000003357278211_9941084.01724.0argonaute proteins
TgeneTNRC6Bchr22:41546202chr22:40681649ENST0000040220311241_994390.01030.0argonaute proteins
TgeneTNRC6Bchr22:41546202chr22:40681649ENST0000045434910231_9941194.01834.0argonaute proteins


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EP300-TNRC6B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EP300-TNRC6B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEP300C0279626Squamous cell carcinoma of esophagus2CTD_human
HgeneEP300C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneEP300C0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneEP300C0005695Bladder Neoplasm1CTD_human
HgeneEP300C0006142Malignant neoplasm of breast1CGI;CTD_human;UNIPROT
HgeneEP300C0007137Squamous cell carcinoma1CTD_human
HgeneEP300C0007138Carcinoma, Transitional Cell1CTD_human
HgeneEP300C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneEP300C0014170Endometrial Neoplasms1CTD_human
HgeneEP300C0014518Toxic Epidermal Necrolysis1CTD_human
HgeneEP300C0025202melanoma1CTD_human
HgeneEP300C0028754Obesity1CTD_human
HgeneEP300C0038325Stevens-Johnson Syndrome1CTD_human
HgeneEP300C0079772T-Cell Lymphoma1CTD_human
HgeneEP300C0149925Small cell carcinoma of lung1CTD_human
HgeneEP300C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneEP300C0376634Craniofacial Abnormalities1CTD_human
HgeneEP300C0476089Endometrial Carcinoma1CTD_human
HgeneEP300C0678222Breast Carcinoma1CGI;CTD_human
HgeneEP300C1257931Mammary Neoplasms, Human1CTD_human
HgeneEP300C1274933Drug-Induced Stevens Johnson Syndrome1CTD_human
HgeneEP300C1458155Mammary Neoplasms1CTD_human
HgeneEP300C3150941RUBINSTEIN-TAYBI SYNDROME 21GENOMICS_ENGLAND
HgeneEP300C3658301Mycoplasma-Induced Stevens-Johnson Syndrome1CTD_human
HgeneEP300C3658302Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum1CTD_human
HgeneEP300C4704874Mammary Carcinoma, Human1CTD_human
TgeneC0032460Polycystic Ovary Syndrome1CTD_human
TgeneC1136382Sclerocystic Ovaries1CTD_human
TgeneC1535926Neurodevelopmental Disorders1CTD_human