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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ALAS1-HHEX (FusionGDB2 ID:HG211TG3087) |
Fusion Gene Summary for ALAS1-HHEX |
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Fusion gene information | Fusion gene name: ALAS1-HHEX | Fusion gene ID: hg211tg3087 | Hgene | Tgene | Gene symbol | ALAS1 | HHEX | Gene ID | 211 | 3087 |
Gene name | 5'-aminolevulinate synthase 1 | hematopoietically expressed homeobox | |
Synonyms | ALAS|ALAS-H|ALAS3|ALASH|MIG4 | HEX|HMPH|HOX11L-PEN|PRH|PRHX | |
Cytomap | ('ALAS1')('HHEX') 3p21.2 | 10q23.33 | |
Type of gene | protein-coding | protein-coding | |
Description | 5-aminolevulinate synthase, nonspecific, mitochondrial5-aminolevulinic acid synthase 1aminolevulinate, delta-, synthase 1delta-ALA synthase 1delta-aminolevulinate synthase 1migration-inducing protein 4 | hematopoietically-expressed homeobox protein HHEXhomeobox protein HEXhomeobox protein PRHhomeobox, hematopoietically expressedproline-rich homeodomain-containing transcription factor | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000310271, ENST00000394965, ENST00000469224, ENST00000484952, | ||
Fusion gene scores | * DoF score | 6 X 6 X 5=180 | 2 X 2 X 2=8 |
# samples | 6 | 2 | |
** MAII score | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: ALAS1 [Title/Abstract] AND HHEX [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ALAS1(52242227)-HHEX(94449946), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | ALAS1-HHEX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ALAS1-HHEX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | HHEX | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10871399|15016828 |
Tgene | HHEX | GO:0006406 | mRNA export from nucleus | 12554669 |
Tgene | HHEX | GO:0034504 | protein localization to nucleus | 18713067 |
Tgene | HHEX | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | 12554669 |
Tgene | HHEX | GO:0045892 | negative regulation of transcription, DNA-templated | 10871399|15016828 |
Tgene | HHEX | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12655000 |
Tgene | HHEX | GO:0070663 | regulation of leukocyte proliferation | 12554669 |
Tgene | HHEX | GO:0071103 | DNA conformation change | 18755198 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-AN-A0XT-01A | ALAS1 | chr3 | 52242227 | + | HHEX | chr10 | 94449946 | + |
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Fusion Gene ORF analysis for ALAS1-HHEX |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000310271 | ENST00000472590 | ALAS1 | chr3 | 52242227 | + | HHEX | chr10 | 94449946 | + |
5CDS-intron | ENST00000310271 | ENST00000492654 | ALAS1 | chr3 | 52242227 | + | HHEX | chr10 | 94449946 | + |
5CDS-intron | ENST00000394965 | ENST00000472590 | ALAS1 | chr3 | 52242227 | + | HHEX | chr10 | 94449946 | + |
5CDS-intron | ENST00000394965 | ENST00000492654 | ALAS1 | chr3 | 52242227 | + | HHEX | chr10 | 94449946 | + |
5CDS-intron | ENST00000469224 | ENST00000472590 | ALAS1 | chr3 | 52242227 | + | HHEX | chr10 | 94449946 | + |
5CDS-intron | ENST00000469224 | ENST00000492654 | ALAS1 | chr3 | 52242227 | + | HHEX | chr10 | 94449946 | + |
5CDS-intron | ENST00000484952 | ENST00000472590 | ALAS1 | chr3 | 52242227 | + | HHEX | chr10 | 94449946 | + |
5CDS-intron | ENST00000484952 | ENST00000492654 | ALAS1 | chr3 | 52242227 | + | HHEX | chr10 | 94449946 | + |
In-frame | ENST00000310271 | ENST00000282728 | ALAS1 | chr3 | 52242227 | + | HHEX | chr10 | 94449946 | + |
In-frame | ENST00000394965 | ENST00000282728 | ALAS1 | chr3 | 52242227 | + | HHEX | chr10 | 94449946 | + |
In-frame | ENST00000469224 | ENST00000282728 | ALAS1 | chr3 | 52242227 | + | HHEX | chr10 | 94449946 | + |
In-frame | ENST00000484952 | ENST00000282728 | ALAS1 | chr3 | 52242227 | + | HHEX | chr10 | 94449946 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000469224 | ALAS1 | chr3 | 52242227 | + | ENST00000282728 | HHEX | chr10 | 94449946 | + | 2891 | 1403 | 196 | 1521 | 441 |
ENST00000394965 | ALAS1 | chr3 | 52242227 | + | ENST00000282728 | HHEX | chr10 | 94449946 | + | 3049 | 1561 | 63 | 1679 | 538 |
ENST00000310271 | ALAS1 | chr3 | 52242227 | + | ENST00000282728 | HHEX | chr10 | 94449946 | + | 2834 | 1346 | 25 | 1464 | 479 |
ENST00000484952 | ALAS1 | chr3 | 52242227 | + | ENST00000282728 | HHEX | chr10 | 94449946 | + | 3010 | 1522 | 315 | 1640 | 441 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000469224 | ENST00000282728 | ALAS1 | chr3 | 52242227 | + | HHEX | chr10 | 94449946 | + | 0.002700741 | 0.99729925 |
ENST00000394965 | ENST00000282728 | ALAS1 | chr3 | 52242227 | + | HHEX | chr10 | 94449946 | + | 0.002019502 | 0.99798054 |
ENST00000310271 | ENST00000282728 | ALAS1 | chr3 | 52242227 | + | HHEX | chr10 | 94449946 | + | 0.002460248 | 0.99753976 |
ENST00000484952 | ENST00000282728 | ALAS1 | chr3 | 52242227 | + | HHEX | chr10 | 94449946 | + | 0.002405919 | 0.99759406 |
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Fusion Genomic Features for ALAS1-HHEX |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ALAS1-HHEX |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52242227/chr10:94449946) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | HHEX | chr3:52242227 | chr10:94449946 | ENST00000282728 | 0 | 4 | 1_133 | 0 | 271.0 | Compositional bias | Note=Pro-rich | |
Tgene | HHEX | chr3:52242227 | chr10:94449946 | ENST00000282728 | 0 | 4 | 137_196 | 0 | 271.0 | DNA binding | Homeobox | |
Tgene | HHEX | chr3:52242227 | chr10:94449946 | ENST00000282728 | 0 | 4 | 137_270 | 0 | 271.0 | Region | Required for WNT signaling induction |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ALAS1-HHEX |
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>3718_3718_1_ALAS1-HHEX_ALAS1_chr3_52242227_ENST00000310271_HHEX_chr10_94449946_ENST00000282728_length(transcript)=2834nt_BP=1346nt ATATTAAGGCGCCGGCGATCGCGGCCTGAGGCTGCTCCCGGACAAGGGCAACGAGCGTTTCGTTTGGACTTCTCGACTTGAGTGCCCGCC TCCTTCGCCGCCGCCTCTGCAGTCCTCAGCGCAGGAGCCAGCATACTTCCTGAACATGGAGAGTGTTGTTCGCCGCTGCCCATTCTTATC CCGAGTCCCCCAGGCCTTTCTGCAGAAAGCAGGCAAATCTCTGTTGTTCTATGCCCAAAACTGCCCCAAGATGATGGAAGTTGGGGCCAA GCCAGCCCCTCGGGCATTGTCCACTGCAGCAGTACACTACCAACAGATCAAAGAAACCCCTCCGGCCAGTGAGAAAGACAAAACTGCTAA GGCCAAGGTCCAACAGACTCCTGATGGATCCCAGCAGAGTCCAGATGGCACACAGCTTCCGTCTGGACACCCCTTGCCTGCCACAAGCCA GGGCACTGCAAGCAAATGCCCTTTCCTGGCAGCACAGATGAATCAGAGAGGCAGCAGTGTCTTCTGCAAAGCCAGTCTTGAGCTTCAGGA GGATGTGCAGGAAATGAATGCCGTGAGGAAAGAGGTTGCTGAAACCTCAGCAGGCCCCAGTGTGGTTAGTGTGAAAACCGATGGAGGGGA TCCCAGTGGACTGCTGAAGAACTTCCAGGACATCATGCAAAAGCAAAGACCAGAAAGAGTGTCTCATCTTCTTCAAGATAACTTGCCAAA ATCTGTTTCCACTTTTCAGTATGATCGTTTCTTTGAGAAAAAAATTGATGAGAAAAAGAATGACCACACCTATCGAGTTTTTAAAACTGT GAACCGGCGAGCACACATCTTCCCCATGGCAGATGACTATTCAGACTCCCTCATCACCAAAAAGCAAGTGTCAGTCTGGTGCAGTAATGA CTACCTAGGAATGAGTCGCCACCCACGGGTGTGTGGGGCAGTTATGGACACTTTGAAACAACATGGTGCTGGGGCAGGTGGTACTAGAAA TATTTCTGGAACTAGTAAATTCCATGTGGACTTAGAGCGGGAGCTGGCAGACCTCCATGGGAAAGATGCCGCACTCTTGTTTTCCTCGTG CTTTGTGGCCAATGACTCAACCCTCTTCACCCTGGCTAAGATGATGCCAGGCTGTGAGATTTACTCTGATTCTGGGAACCATGCCTCCAT GATCCAAGGGATTCGAAACAGCCGAGTGCCAAAGTACATCTTCCGCCACAATGATGTCAGCCACCTCAGAGAACTGCTGCAAAGATCTGA CCCCTCAGTCCCCAAGATTGTGGCATTTGAAACTGTCCATTCAATGGATGTCATGCCAAAAATGGACATCATTTCTGGAACACTTGGGTG TACGAGCCCACGCCGATCCATCCAGCCTTCTCGCACCACTCCGCCGCCGCGCTGGCCGCTGCCTACGGACCCGGCGGCTTCGGGGGCCCT CTGTACCCCTTCCCGCGGACGGTGAACGACTACACGCACGCCCTGCTCCGCCACGACCCCCTGGGCAAACCTCTACTCTGGAGCCCCTTC TTGCAGAGGCCTCTGCATAAAAGGAAAGGCGGCCAGGTGAGATTCTCCAACGACCAGACCATCGAGCTGGAGAAGAAATTCGAGACGCAG AAATATCTCTCTCCGCCCGAGAGGAAGCGTCTGGCCAAGATGCTGCAGCTCAGCGAGAGACAGGTCAAAACCTGGTTTCAGAATCGACGC GCTAAATGGAGGAGACTAAAACAGGAGAACCCTCAAAGCAATAAAAAAGAAGAACTGGAAAGTTTGGACAGTTCCTGTGATCAGAGGCAA GATTTGCCCAGTGAACAGAATAAAGGTGCTTCTTTGGATAGCTCTCAATGTTCGCCCTCCCCTGCCTCCCAGGAAGACCTTGAATCAGAG ATTTCAGAGGATTCTGATCAGGAAGTGGACATTGAGGGCGATAAAAGCTATTTTAATGCTGGATGATGACCACTGGCATTGGCATGTTCA GAAAACTGGATTTAGGAATAATGTTTTGCTACAGAAAATCTTCATAGAAGAACTGGAAGGCTATATAAGAAAGGGAATCAATTCTCTGGT ATTCTGGAAACCTAAAAATATTTGGTGCACTGCTCAATTAACAAACCTACATGGAGACCTTAATTTTGACTTAACAAATAGTTTATGTAC TGCTCTTAGGTTGTTTTGATAAAGTGACATTATAGTGATTAAATTCTTCCCCCTTTAAAAAAACAGTTAGTGGTTTTCACTATTTATAAA AAATTAATTTTGAACTTTTTGTTAAATTTTTAAGTTATAGCTTTAAAGGTTTTAATAGGACCTTCTTGAACGACTTTTCTGTAATCTGTT TATCTCCCACTTAATGGAAAGGCAAAGGGGTACCCCAAATCCAGAGGTGCCTACATTTCAGGCAGCCTTGGAGTATTTTAAAAGGAAAAC ATTCTTTACTTTTATATGACATTCTTATACTGCTGTCTCAAATCCAAAAACATTTCAGAGCTCTTGTCTCAGAGATGTGTGTTCTTTTTG TCAGAGATATGGTTGATGAGAATCTTAAATGCTTGTTTTGCACTATCACTTAGTACCTGTTTGACCAAGGTGTTAAGGGGATAGTACCTC CCAATTCAAGCAGAGAAACTGACCTGACTAAAGTTAATCGCAGATGAACTAGAAGTCACAGGTTAATTAAATGTAAGTAGATTGTAGATA CTGTTTTATATCAAACAATGTTTATAATGTGTATATAGAATTGTTCACTGTAAAAAAAATGGCCAAAATGTGTTTTTTTTTTAATAAGTA >3718_3718_1_ALAS1-HHEX_ALAS1_chr3_52242227_ENST00000310271_HHEX_chr10_94449946_ENST00000282728_length(amino acids)=479AA_BP=441 MRLLPDKGNERFVWTSRLECPPPSPPPLQSSAQEPAYFLNMESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALST AAVHYQQIKETPPASEKDKTAKAKVQQTPDGSQQSPDGTQLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEMNAV RKEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIMQKQRPERVSHLLQDNLPKSVSTFQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFP MADDYSDSLITKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTL FTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQRSDPSVPKIVAFETVHSMDVMPKMDIISGTLGCTSPRRSIQ -------------------------------------------------------------- >3718_3718_2_ALAS1-HHEX_ALAS1_chr3_52242227_ENST00000394965_HHEX_chr10_94449946_ENST00000282728_length(transcript)=3049nt_BP=1561nt AGCGCCCAAGGCGCATGCGCAGCGGTCACTCCCGCTGTATATTAAGGCGCCGGCGATCGCGGCCTGAGGCTGCTCCCGGACAAGGGCAAC GAGCGTTTCGTTTGGACTTCTCGACTTGAGTGCCCGCCTCCTTCGCCGCCGCCTCTGCAGTCCTCAGCGCAGTTATGCCCAGTTCTTCCC GCTGTGGGGACACGACCACGGAGGAATCCTTGCTTCAGGGACTCGGGACCCTGCTGGACCCCTTCCTCGGGTTTAGGGGATGTGGGGACC AGGAGAAAGTCAGGATCCCTAAGAGTCTTCCCTGCCTGGATGGATGAGTGGCTTCTTCTCCACCTAGATGAGCCAGCATACTTCCTGAAC ATGGAGAGTGTTGTTCGCCGCTGCCCATTCTTATCCCGAGTCCCCCAGGCCTTTCTGCAGAAAGCAGGCAAATCTCTGTTGTTCTATGCC CAAAACTGCCCCAAGATGATGGAAGTTGGGGCCAAGCCAGCCCCTCGGGCATTGTCCACTGCAGCAGTACACTACCAACAGATCAAAGAA ACCCCTCCGGCCAGTGAGAAAGACAAAACTGCTAAGGCCAAGGTCCAACAGACTCCTGATGGATCCCAGCAGAGTCCAGATGGCACACAG CTTCCGTCTGGACACCCCTTGCCTGCCACAAGCCAGGGCACTGCAAGCAAATGCCCTTTCCTGGCAGCACAGATGAATCAGAGAGGCAGC AGTGTCTTCTGCAAAGCCAGTCTTGAGCTTCAGGAGGATGTGCAGGAAATGAATGCCGTGAGGAAAGAGGTTGCTGAAACCTCAGCAGGC CCCAGTGTGGTTAGTGTGAAAACCGATGGAGGGGATCCCAGTGGACTGCTGAAGAACTTCCAGGACATCATGCAAAAGCAAAGACCAGAA AGAGTGTCTCATCTTCTTCAAGATAACTTGCCAAAATCTGTTTCCACTTTTCAGTATGATCGTTTCTTTGAGAAAAAAATTGATGAGAAA AAGAATGACCACACCTATCGAGTTTTTAAAACTGTGAACCGGCGAGCACACATCTTCCCCATGGCAGATGACTATTCAGACTCCCTCATC ACCAAAAAGCAAGTGTCAGTCTGGTGCAGTAATGACTACCTAGGAATGAGTCGCCACCCACGGGTGTGTGGGGCAGTTATGGACACTTTG AAACAACATGGTGCTGGGGCAGGTGGTACTAGAAATATTTCTGGAACTAGTAAATTCCATGTGGACTTAGAGCGGGAGCTGGCAGACCTC CATGGGAAAGATGCCGCACTCTTGTTTTCCTCGTGCTTTGTGGCCAATGACTCAACCCTCTTCACCCTGGCTAAGATGATGCCAGGCTGT GAGATTTACTCTGATTCTGGGAACCATGCCTCCATGATCCAAGGGATTCGAAACAGCCGAGTGCCAAAGTACATCTTCCGCCACAATGAT GTCAGCCACCTCAGAGAACTGCTGCAAAGATCTGACCCCTCAGTCCCCAAGATTGTGGCATTTGAAACTGTCCATTCAATGGATGTCATG CCAAAAATGGACATCATTTCTGGAACACTTGGGTGTACGAGCCCACGCCGATCCATCCAGCCTTCTCGCACCACTCCGCCGCCGCGCTGG CCGCTGCCTACGGACCCGGCGGCTTCGGGGGCCCTCTGTACCCCTTCCCGCGGACGGTGAACGACTACACGCACGCCCTGCTCCGCCACG ACCCCCTGGGCAAACCTCTACTCTGGAGCCCCTTCTTGCAGAGGCCTCTGCATAAAAGGAAAGGCGGCCAGGTGAGATTCTCCAACGACC AGACCATCGAGCTGGAGAAGAAATTCGAGACGCAGAAATATCTCTCTCCGCCCGAGAGGAAGCGTCTGGCCAAGATGCTGCAGCTCAGCG AGAGACAGGTCAAAACCTGGTTTCAGAATCGACGCGCTAAATGGAGGAGACTAAAACAGGAGAACCCTCAAAGCAATAAAAAAGAAGAAC TGGAAAGTTTGGACAGTTCCTGTGATCAGAGGCAAGATTTGCCCAGTGAACAGAATAAAGGTGCTTCTTTGGATAGCTCTCAATGTTCGC CCTCCCCTGCCTCCCAGGAAGACCTTGAATCAGAGATTTCAGAGGATTCTGATCAGGAAGTGGACATTGAGGGCGATAAAAGCTATTTTA ATGCTGGATGATGACCACTGGCATTGGCATGTTCAGAAAACTGGATTTAGGAATAATGTTTTGCTACAGAAAATCTTCATAGAAGAACTG GAAGGCTATATAAGAAAGGGAATCAATTCTCTGGTATTCTGGAAACCTAAAAATATTTGGTGCACTGCTCAATTAACAAACCTACATGGA GACCTTAATTTTGACTTAACAAATAGTTTATGTACTGCTCTTAGGTTGTTTTGATAAAGTGACATTATAGTGATTAAATTCTTCCCCCTT TAAAAAAACAGTTAGTGGTTTTCACTATTTATAAAAAATTAATTTTGAACTTTTTGTTAAATTTTTAAGTTATAGCTTTAAAGGTTTTAA TAGGACCTTCTTGAACGACTTTTCTGTAATCTGTTTATCTCCCACTTAATGGAAAGGCAAAGGGGTACCCCAAATCCAGAGGTGCCTACA TTTCAGGCAGCCTTGGAGTATTTTAAAAGGAAAACATTCTTTACTTTTATATGACATTCTTATACTGCTGTCTCAAATCCAAAAACATTT CAGAGCTCTTGTCTCAGAGATGTGTGTTCTTTTTGTCAGAGATATGGTTGATGAGAATCTTAAATGCTTGTTTTGCACTATCACTTAGTA CCTGTTTGACCAAGGTGTTAAGGGGATAGTACCTCCCAATTCAAGCAGAGAAACTGACCTGACTAAAGTTAATCGCAGATGAACTAGAAG TCACAGGTTAATTAAATGTAAGTAGATTGTAGATACTGTTTTATATCAAACAATGTTTATAATGTGTATATAGAATTGTTCACTGTAAAA >3718_3718_2_ALAS1-HHEX_ALAS1_chr3_52242227_ENST00000394965_HHEX_chr10_94449946_ENST00000282728_length(amino acids)=538AA_BP=500 MRLLPDKGNERFVWTSRLECPPPSPPPLQSSAQLCPVLPAVGTRPRRNPCFRDSGPCWTPSSGLGDVGTRRKSGSLRVFPAWMDEWLLLH LDEPAYFLNMESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALSTAAVHYQQIKETPPASEKDKTAKAKVQQTPDG SQQSPDGTQLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEMNAVRKEVAETSAGPSVVSVKTDGGDPSGLLKNFQ DIMQKQRPERVSHLLQDNLPKSVSTFQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSLITKKQVSVWCSNDYLGMSRHPR VCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRV -------------------------------------------------------------- >3718_3718_3_ALAS1-HHEX_ALAS1_chr3_52242227_ENST00000469224_HHEX_chr10_94449946_ENST00000282728_length(transcript)=2891nt_BP=1403nt AAGAAGGCAGCGCCCAAGGCGCATGCGCAGCGGTCACTCCCGCTGTATATTAAGGCGCCGGCGATCGCGGCCTGAGGCTGCTCCCGGACA AGGGCAACGAGCGTTTCGTTTGGACTTCTCGACTTGAGTGCCCGCCTCCTTCGCCGCCGCCTCTGCAGTCCTCAGCGCAGTCTTTCCACA GGAGCCAGCATACTTCCTGAACATGGAGAGTGTTGTTCGCCGCTGCCCATTCTTATCCCGAGTCCCCCAGGCCTTTCTGCAGAAAGCAGG CAAATCTCTGTTGTTCTATGCCCAAAACTGCCCCAAGATGATGGAAGTTGGGGCCAAGCCAGCCCCTCGGGCATTGTCCACTGCAGCAGT ACACTACCAACAGATCAAAGAAACCCCTCCGGCCAGTGAGAAAGACAAAACTGCTAAGGCCAAGGTCCAACAGACTCCTGATGGATCCCA GCAGAGTCCAGATGGCACACAGCTTCCGTCTGGACACCCCTTGCCTGCCACAAGCCAGGGCACTGCAAGCAAATGCCCTTTCCTGGCAGC ACAGATGAATCAGAGAGGCAGCAGTGTCTTCTGCAAAGCCAGTCTTGAGCTTCAGGAGGATGTGCAGGAAATGAATGCCGTGAGGAAAGA GGTTGCTGAAACCTCAGCAGGCCCCAGTGTGGTTAGTGTGAAAACCGATGGAGGGGATCCCAGTGGACTGCTGAAGAACTTCCAGGACAT CATGCAAAAGCAAAGACCAGAAAGAGTGTCTCATCTTCTTCAAGATAACTTGCCAAAATCTGTTTCCACTTTTCAGTATGATCGTTTCTT TGAGAAAAAAATTGATGAGAAAAAGAATGACCACACCTATCGAGTTTTTAAAACTGTGAACCGGCGAGCACACATCTTCCCCATGGCAGA TGACTATTCAGACTCCCTCATCACCAAAAAGCAAGTGTCAGTCTGGTGCAGTAATGACTACCTAGGAATGAGTCGCCACCCACGGGTGTG TGGGGCAGTTATGGACACTTTGAAACAACATGGTGCTGGGGCAGGTGGTACTAGAAATATTTCTGGAACTAGTAAATTCCATGTGGACTT AGAGCGGGAGCTGGCAGACCTCCATGGGAAAGATGCCGCACTCTTGTTTTCCTCGTGCTTTGTGGCCAATGACTCAACCCTCTTCACCCT GGCTAAGATGATGCCAGGCTGTGAGATTTACTCTGATTCTGGGAACCATGCCTCCATGATCCAAGGGATTCGAAACAGCCGAGTGCCAAA GTACATCTTCCGCCACAATGATGTCAGCCACCTCAGAGAACTGCTGCAAAGATCTGACCCCTCAGTCCCCAAGATTGTGGCATTTGAAAC TGTCCATTCAATGGATGTCATGCCAAAAATGGACATCATTTCTGGAACACTTGGGTGTACGAGCCCACGCCGATCCATCCAGCCTTCTCG CACCACTCCGCCGCCGCGCTGGCCGCTGCCTACGGACCCGGCGGCTTCGGGGGCCCTCTGTACCCCTTCCCGCGGACGGTGAACGACTAC ACGCACGCCCTGCTCCGCCACGACCCCCTGGGCAAACCTCTACTCTGGAGCCCCTTCTTGCAGAGGCCTCTGCATAAAAGGAAAGGCGGC CAGGTGAGATTCTCCAACGACCAGACCATCGAGCTGGAGAAGAAATTCGAGACGCAGAAATATCTCTCTCCGCCCGAGAGGAAGCGTCTG GCCAAGATGCTGCAGCTCAGCGAGAGACAGGTCAAAACCTGGTTTCAGAATCGACGCGCTAAATGGAGGAGACTAAAACAGGAGAACCCT CAAAGCAATAAAAAAGAAGAACTGGAAAGTTTGGACAGTTCCTGTGATCAGAGGCAAGATTTGCCCAGTGAACAGAATAAAGGTGCTTCT TTGGATAGCTCTCAATGTTCGCCCTCCCCTGCCTCCCAGGAAGACCTTGAATCAGAGATTTCAGAGGATTCTGATCAGGAAGTGGACATT GAGGGCGATAAAAGCTATTTTAATGCTGGATGATGACCACTGGCATTGGCATGTTCAGAAAACTGGATTTAGGAATAATGTTTTGCTACA GAAAATCTTCATAGAAGAACTGGAAGGCTATATAAGAAAGGGAATCAATTCTCTGGTATTCTGGAAACCTAAAAATATTTGGTGCACTGC TCAATTAACAAACCTACATGGAGACCTTAATTTTGACTTAACAAATAGTTTATGTACTGCTCTTAGGTTGTTTTGATAAAGTGACATTAT AGTGATTAAATTCTTCCCCCTTTAAAAAAACAGTTAGTGGTTTTCACTATTTATAAAAAATTAATTTTGAACTTTTTGTTAAATTTTTAA GTTATAGCTTTAAAGGTTTTAATAGGACCTTCTTGAACGACTTTTCTGTAATCTGTTTATCTCCCACTTAATGGAAAGGCAAAGGGGTAC CCCAAATCCAGAGGTGCCTACATTTCAGGCAGCCTTGGAGTATTTTAAAAGGAAAACATTCTTTACTTTTATATGACATTCTTATACTGC TGTCTCAAATCCAAAAACATTTCAGAGCTCTTGTCTCAGAGATGTGTGTTCTTTTTGTCAGAGATATGGTTGATGAGAATCTTAAATGCT TGTTTTGCACTATCACTTAGTACCTGTTTGACCAAGGTGTTAAGGGGATAGTACCTCCCAATTCAAGCAGAGAAACTGACCTGACTAAAG TTAATCGCAGATGAACTAGAAGTCACAGGTTAATTAAATGTAAGTAGATTGTAGATACTGTTTTATATCAAACAATGTTTATAATGTGTA TATAGAATTGTTCACTGTAAAAAAAATGGCCAAAATGTGTTTTTTTTTTAATAAGTAACTTGACTATAAAATAAAGCCGTCCGTGGGACG >3718_3718_3_ALAS1-HHEX_ALAS1_chr3_52242227_ENST00000469224_HHEX_chr10_94449946_ENST00000282728_length(amino acids)=441AA_BP=403 MNMESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALSTAAVHYQQIKETPPASEKDKTAKAKVQQTPDGSQQSPDG TQLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEMNAVRKEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIMQKQR PERVSHLLQDNLPKSVSTFQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSLITKKQVSVWCSNDYLGMSRHPRVCGAVMD TLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRH -------------------------------------------------------------- >3718_3718_4_ALAS1-HHEX_ALAS1_chr3_52242227_ENST00000484952_HHEX_chr10_94449946_ENST00000282728_length(transcript)=3010nt_BP=1522nt CGGCGATCGCGGCCTGAGGCTGCTCCCGGACAAGGGCAACGAGCGTTTCGTTTGGACTTCTCGACTTGAGTGCCCGCCTCCTTCGCCGCC GCCTCTGCAGTCCTCAGCGCAGTTATGCCCAGTTCTTCCCGCTGTGGGGACACGACCACGGAGGAATCCTTGCTTCAGGGACTCGGGACC CTGCTGGACCCCTTCCTCGGGTTTAGGGGATGTGGGGACCAGGAGAAAGTCAGGATCCCTAAGAGTCTTCCCTGCCTGGATGGATGAGTG GCTTCTTCTCCACCTAGATTCTTTCCACAGGAGCCAGCATACTTCCTGAACATGGAGAGTGTTGTTCGCCGCTGCCCATTCTTATCCCGA GTCCCCCAGGCCTTTCTGCAGAAAGCAGGCAAATCTCTGTTGTTCTATGCCCAAAACTGCCCCAAGATGATGGAAGTTGGGGCCAAGCCA GCCCCTCGGGCATTGTCCACTGCAGCAGTACACTACCAACAGATCAAAGAAACCCCTCCGGCCAGTGAGAAAGACAAAACTGCTAAGGCC AAGGTCCAACAGACTCCTGATGGATCCCAGCAGAGTCCAGATGGCACACAGCTTCCGTCTGGACACCCCTTGCCTGCCACAAGCCAGGGC ACTGCAAGCAAATGCCCTTTCCTGGCAGCACAGATGAATCAGAGAGGCAGCAGTGTCTTCTGCAAAGCCAGTCTTGAGCTTCAGGAGGAT GTGCAGGAAATGAATGCCGTGAGGAAAGAGGTTGCTGAAACCTCAGCAGGCCCCAGTGTGGTTAGTGTGAAAACCGATGGAGGGGATCCC AGTGGACTGCTGAAGAACTTCCAGGACATCATGCAAAAGCAAAGACCAGAAAGAGTGTCTCATCTTCTTCAAGATAACTTGCCAAAATCT GTTTCCACTTTTCAGTATGATCGTTTCTTTGAGAAAAAAATTGATGAGAAAAAGAATGACCACACCTATCGAGTTTTTAAAACTGTGAAC CGGCGAGCACACATCTTCCCCATGGCAGATGACTATTCAGACTCCCTCATCACCAAAAAGCAAGTGTCAGTCTGGTGCAGTAATGACTAC CTAGGAATGAGTCGCCACCCACGGGTGTGTGGGGCAGTTATGGACACTTTGAAACAACATGGTGCTGGGGCAGGTGGTACTAGAAATATT TCTGGAACTAGTAAATTCCATGTGGACTTAGAGCGGGAGCTGGCAGACCTCCATGGGAAAGATGCCGCACTCTTGTTTTCCTCGTGCTTT GTGGCCAATGACTCAACCCTCTTCACCCTGGCTAAGATGATGCCAGGCTGTGAGATTTACTCTGATTCTGGGAACCATGCCTCCATGATC CAAGGGATTCGAAACAGCCGAGTGCCAAAGTACATCTTCCGCCACAATGATGTCAGCCACCTCAGAGAACTGCTGCAAAGATCTGACCCC TCAGTCCCCAAGATTGTGGCATTTGAAACTGTCCATTCAATGGATGTCATGCCAAAAATGGACATCATTTCTGGAACACTTGGGTGTACG AGCCCACGCCGATCCATCCAGCCTTCTCGCACCACTCCGCCGCCGCGCTGGCCGCTGCCTACGGACCCGGCGGCTTCGGGGGCCCTCTGT ACCCCTTCCCGCGGACGGTGAACGACTACACGCACGCCCTGCTCCGCCACGACCCCCTGGGCAAACCTCTACTCTGGAGCCCCTTCTTGC AGAGGCCTCTGCATAAAAGGAAAGGCGGCCAGGTGAGATTCTCCAACGACCAGACCATCGAGCTGGAGAAGAAATTCGAGACGCAGAAAT ATCTCTCTCCGCCCGAGAGGAAGCGTCTGGCCAAGATGCTGCAGCTCAGCGAGAGACAGGTCAAAACCTGGTTTCAGAATCGACGCGCTA AATGGAGGAGACTAAAACAGGAGAACCCTCAAAGCAATAAAAAAGAAGAACTGGAAAGTTTGGACAGTTCCTGTGATCAGAGGCAAGATT TGCCCAGTGAACAGAATAAAGGTGCTTCTTTGGATAGCTCTCAATGTTCGCCCTCCCCTGCCTCCCAGGAAGACCTTGAATCAGAGATTT CAGAGGATTCTGATCAGGAAGTGGACATTGAGGGCGATAAAAGCTATTTTAATGCTGGATGATGACCACTGGCATTGGCATGTTCAGAAA ACTGGATTTAGGAATAATGTTTTGCTACAGAAAATCTTCATAGAAGAACTGGAAGGCTATATAAGAAAGGGAATCAATTCTCTGGTATTC TGGAAACCTAAAAATATTTGGTGCACTGCTCAATTAACAAACCTACATGGAGACCTTAATTTTGACTTAACAAATAGTTTATGTACTGCT CTTAGGTTGTTTTGATAAAGTGACATTATAGTGATTAAATTCTTCCCCCTTTAAAAAAACAGTTAGTGGTTTTCACTATTTATAAAAAAT TAATTTTGAACTTTTTGTTAAATTTTTAAGTTATAGCTTTAAAGGTTTTAATAGGACCTTCTTGAACGACTTTTCTGTAATCTGTTTATC TCCCACTTAATGGAAAGGCAAAGGGGTACCCCAAATCCAGAGGTGCCTACATTTCAGGCAGCCTTGGAGTATTTTAAAAGGAAAACATTC TTTACTTTTATATGACATTCTTATACTGCTGTCTCAAATCCAAAAACATTTCAGAGCTCTTGTCTCAGAGATGTGTGTTCTTTTTGTCAG AGATATGGTTGATGAGAATCTTAAATGCTTGTTTTGCACTATCACTTAGTACCTGTTTGACCAAGGTGTTAAGGGGATAGTACCTCCCAA TTCAAGCAGAGAAACTGACCTGACTAAAGTTAATCGCAGATGAACTAGAAGTCACAGGTTAATTAAATGTAAGTAGATTGTAGATACTGT TTTATATCAAACAATGTTTATAATGTGTATATAGAATTGTTCACTGTAAAAAAAATGGCCAAAATGTGTTTTTTTTTTAATAAGTAACTT >3718_3718_4_ALAS1-HHEX_ALAS1_chr3_52242227_ENST00000484952_HHEX_chr10_94449946_ENST00000282728_length(amino acids)=441AA_BP=403 MNMESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALSTAAVHYQQIKETPPASEKDKTAKAKVQQTPDGSQQSPDG TQLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEMNAVRKEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIMQKQR PERVSHLLQDNLPKSVSTFQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSLITKKQVSVWCSNDYLGMSRHPRVCGAVMD TLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRH -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ALAS1-HHEX |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Tgene | HHEX | chr3:52242227 | chr10:94449946 | ENST00000282728 | 0 | 4 | 1_137 | 0 | 271.0 | SOX13 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ALAS1-HHEX |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ALAS1-HHEX |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ALAS1 | C0032708 | Disorders of Porphyrin Metabolism | 1 | CTD_human |
Tgene | C0006142 | Malignant neoplasm of breast | 1 | CTD_human | |
Tgene | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human | |
Tgene | C0015695 | Fatty Liver | 1 | CTD_human | |
Tgene | C0678222 | Breast Carcinoma | 1 | CTD_human | |
Tgene | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human | |
Tgene | C1458155 | Mammary Neoplasms | 1 | CTD_human | |
Tgene | C2711227 | Steatohepatitis | 1 | CTD_human | |
Tgene | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |