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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EWSR1-CREM (FusionGDB2 ID:HG2130TG1390)

Fusion Gene Summary for EWSR1-CREM

check button Fusion gene summary
Fusion gene informationFusion gene name: EWSR1-CREM
Fusion gene ID: hg2130tg1390
HgeneTgene
Gene symbol

EWSR1

CREM

Gene ID

2130

1390

Gene nameEWS RNA binding protein 1cAMP responsive element modulator
SynonymsEWS|EWS-FLI1|bK984G1.4CREM-2|ICER|hCREM-2
Cytomap('EWSR1')('CREM')

22q12.2

10p11.21

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein EWSEWS RNA-binding protein variant 6Ewing sarcoma breakpoint region 1Ewings sarcoma EWS-Fli1 (type 1) oncogenecAMP-responsive element modulatorCREM 2alpha-b proteinCREM 2beta-a proteincAMP response element modulatorinducible cAMP early repressor ICER
Modification date2020032920200313
UniProtAcc

Q01844

Q03060

Ensembl transtripts involved in fusion geneENST00000331029, ENST00000332035, 
ENST00000332050, ENST00000333395, 
ENST00000397938, ENST00000406548, 
ENST00000414183, 
Fusion gene scores* DoF score44 X 91 X 16=6406412 X 12 X 7=1008
# samples 9812
** MAII scorelog2(98/64064*10)=-6.03058831983342
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/1008*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EWSR1 [Title/Abstract] AND CREM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCREM

GO:0006355

regulation of transcription, DNA-templated

8206879



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB4..EWSR1chr22

29674018

+CREMchr10

29674018

+
ChimerKB4..EWSR1chr22

29678378

+CREMchr10

29678378

+
ChimerKB4..EWSR1chr22

29684594

+CREMchr10

29684594

+


Top

Fusion Gene ORF analysis for EWSR1-CREM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000331029ENST00000333809EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000333809EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000333809EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000337656EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000337656EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000337656EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000342105EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000342105EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000342105EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000344351EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000344351EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000344351EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000345491EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000345491EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000345491EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000348787EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000348787EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000348787EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000354759EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000354759EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000354759EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000356917EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000356917EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000356917EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000361599EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000361599EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000361599EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000374721EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000374721EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000374721EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000374726EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000374726EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000374726EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000374728EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000374728EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000374728EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000374734EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000374734EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000374734EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000395887EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000395887EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000395887EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000395895EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000395895EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000395895EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000429130EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000429130EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000429130EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000439705EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000439705EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000439705EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000460270EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000460270EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000460270EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000463314EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000463314EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000463314EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000463960EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000463960EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000463960EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000468236EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000468236EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000468236EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000469949EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000469949EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000469949EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000473940EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000473940EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000473940EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000474362EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000474362EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000474362EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000474931EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000474931EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000474931EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000479070EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000479070EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000479070EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000484283EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000484283EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000484283EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000487763EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000487763EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000487763EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000488328EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000488328EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000488328EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000488741EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000488741EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000488741EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000489321EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000489321EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000489321EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000489388EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000489388EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000489388EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000331029ENST00000490511EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000331029ENST00000490511EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000331029ENST00000490511EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000333809EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000333809EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000333809EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000337656EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000337656EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000337656EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000342105EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000342105EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000342105EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000344351EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000344351EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000344351EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000345491EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000345491EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000345491EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000348787EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000348787EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000348787EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000354759EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000354759EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000354759EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000356917EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000356917EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000356917EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000361599EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000361599EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000361599EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000374721EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000374721EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000374721EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000374726EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000374726EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000374726EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000374728EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000374728EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000374728EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000374734EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000374734EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000374734EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000395887EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000395887EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000395887EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000395895EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000395895EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000395895EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000429130EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000429130EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000429130EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000439705EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000439705EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000439705EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000460270EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000460270EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000460270EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000463314EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000463314EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000463314EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000463960EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000463960EWSR1chr22

29678378

+CREMchr10

29678378

+
intron-intronENST00000332035ENST00000463960EWSR1chr22

29684594

+CREMchr10

29684594

+
intron-intronENST00000332035ENST00000468236EWSR1chr22

29674018

+CREMchr10

29674018

+
intron-intronENST00000332035ENST00000468236EWSR1chr22

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check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for EWSR1-CREM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


Top

Fusion Protein Features for EWSR1-CREM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EWSR1

Q01844

CREM

Q03060

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550). {ECO:0000269|PubMed:10373550}.; FUNCTION: [Isoform 6]: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for EWSR1-CREM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for EWSR1-CREM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EWSR1-CREM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EWSR1-CREM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEWSR1C0553580Ewings sarcoma3CTD_human;ORPHANET
HgeneEWSR1C0002736Amyotrophic Lateral Sclerosis1GENOMICS_ENGLAND
HgeneEWSR1C0033578Prostatic Neoplasms1CTD_human
HgeneEWSR1C0206651Clear Cell Sarcoma of Soft Tissue1ORPHANET
HgeneEWSR1C0206663Neuroectodermal Tumor, Primitive1CTD_human
HgeneEWSR1C0279980Extra-osseous Ewing's sarcoma1ORPHANET
HgeneEWSR1C0334584Spongioblastoma1CTD_human
HgeneEWSR1C0334596Medulloepithelioma1CTD_human
HgeneEWSR1C0376358Malignant neoplasm of prostate1CTD_human
HgeneEWSR1C0700367Ependymoblastoma1CTD_human
HgeneEWSR1C0751675Cerebral Primitive Neuroectodermal Tumor1CTD_human
HgeneEWSR1C1275278Extraskeletal Myxoid Chondrosarcoma1ORPHANET
TgeneC0011875Diabetic Angiopathies1CTD_human
TgeneC0020564Hypertrophy1CTD_human
TgeneC0025945Microangiopathy, Diabetic1CTD_human
TgeneC0027051Myocardial Infarction1CTD_human
TgeneC0087031Juvenile-Onset Still Disease1CTD_human
TgeneC0162820Dermatitis, Allergic Contact1CTD_human
TgeneC0263454Chloracne1CTD_human
TgeneC3495559Juvenile arthritis1CTD_human
TgeneC3714758Juvenile psoriatic arthritis1CTD_human
TgeneC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human