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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EWSR1-ZNF444 (FusionGDB2 ID:HG2130TG55311)

Fusion Gene Summary for EWSR1-ZNF444

check button Fusion gene summary
Fusion gene informationFusion gene name: EWSR1-ZNF444
Fusion gene ID: hg2130tg55311
HgeneTgene
Gene symbol

EWSR1

ZNF444

Gene ID

2130

55311

Gene nameEWS RNA binding protein 1zinc finger protein 444
SynonymsEWS|EWS-FLI1|bK984G1.4EZF-2|EZF2|ZSCAN17
Cytomap('EWSR1')('ZNF444')

22q12.2

19q13.43

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein EWSEWS RNA-binding protein variant 6Ewing sarcoma breakpoint region 1Ewings sarcoma EWS-Fli1 (type 1) oncogenezinc finger protein 444endothelial zinc finger protein 2zinc finger and SCAN domain-containing protein 17
Modification date2020032920200313
UniProtAcc

Q01844

Q8N0Y2

Ensembl transtripts involved in fusion geneENST00000331029, ENST00000332035, 
ENST00000332050, ENST00000333395, 
ENST00000397938, ENST00000406548, 
ENST00000414183, 
Fusion gene scores* DoF score44 X 91 X 16=640643 X 3 X 3=27
# samples 983
** MAII scorelog2(98/64064*10)=-6.03058831983342
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EWSR1 [Title/Abstract] AND ZNF444 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint
Anticipated loss of major functional domain due to fusion event.EWSR1-ZNF444 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
EWSR1-ZNF444 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EWSR1-ZNF444 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..EWSR1chr22

29683123

+ZNF444chr19

56670992

+
ChimerKB3..EWSR1chr22

29687588

+ZNF444chr19

56670992

+


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Fusion Gene ORF analysis for EWSR1-ZNF444

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000331029ENST00000592171EWSR1chr22

29683123

+ZNF444chr19

56670992

+
5CDS-3UTRENST00000332035ENST00000592171EWSR1chr22

29683123

+ZNF444chr19

56670992

+
5CDS-3UTRENST00000332035ENST00000592171EWSR1chr22

29687588

+ZNF444chr19

56670992

+
5CDS-3UTRENST00000332050ENST00000592171EWSR1chr22

29683123

+ZNF444chr19

56670992

+
5CDS-3UTRENST00000333395ENST00000592171EWSR1chr22

29683123

+ZNF444chr19

56670992

+
5CDS-3UTRENST00000397938ENST00000592171EWSR1chr22

29683123

+ZNF444chr19

56670992

+
5CDS-3UTRENST00000397938ENST00000592171EWSR1chr22

29687588

+ZNF444chr19

56670992

+
5CDS-3UTRENST00000406548ENST00000592171EWSR1chr22

29683123

+ZNF444chr19

56670992

+
5CDS-3UTRENST00000406548ENST00000592171EWSR1chr22

29687588

+ZNF444chr19

56670992

+
5CDS-3UTRENST00000414183ENST00000592171EWSR1chr22

29683123

+ZNF444chr19

56670992

+
5CDS-3UTRENST00000414183ENST00000592171EWSR1chr22

29687588

+ZNF444chr19

56670992

+
Frame-shiftENST00000331029ENST00000337080EWSR1chr22

29683123

+ZNF444chr19

56670992

+
Frame-shiftENST00000332035ENST00000337080EWSR1chr22

29683123

+ZNF444chr19

56670992

+
Frame-shiftENST00000332035ENST00000337080EWSR1chr22

29687588

+ZNF444chr19

56670992

+
Frame-shiftENST00000332050ENST00000337080EWSR1chr22

29683123

+ZNF444chr19

56670992

+
Frame-shiftENST00000333395ENST00000337080EWSR1chr22

29683123

+ZNF444chr19

56670992

+
Frame-shiftENST00000397938ENST00000337080EWSR1chr22

29683123

+ZNF444chr19

56670992

+
Frame-shiftENST00000397938ENST00000337080EWSR1chr22

29687588

+ZNF444chr19

56670992

+
Frame-shiftENST00000406548ENST00000337080EWSR1chr22

29683123

+ZNF444chr19

56670992

+
Frame-shiftENST00000406548ENST00000337080EWSR1chr22

29687588

+ZNF444chr19

56670992

+
Frame-shiftENST00000414183ENST00000337080EWSR1chr22

29683123

+ZNF444chr19

56670992

+
Frame-shiftENST00000414183ENST00000337080EWSR1chr22

29687588

+ZNF444chr19

56670992

+
In-frameENST00000331029ENST00000592949EWSR1chr22

29683123

+ZNF444chr19

56670992

+
In-frameENST00000332035ENST00000592949EWSR1chr22

29683123

+ZNF444chr19

56670992

+
In-frameENST00000332035ENST00000592949EWSR1chr22

29687588

+ZNF444chr19

56670992

+
In-frameENST00000332050ENST00000592949EWSR1chr22

29683123

+ZNF444chr19

56670992

+
In-frameENST00000333395ENST00000592949EWSR1chr22

29683123

+ZNF444chr19

56670992

+
In-frameENST00000397938ENST00000592949EWSR1chr22

29683123

+ZNF444chr19

56670992

+
In-frameENST00000397938ENST00000592949EWSR1chr22

29687588

+ZNF444chr19

56670992

+
In-frameENST00000406548ENST00000592949EWSR1chr22

29683123

+ZNF444chr19

56670992

+
In-frameENST00000406548ENST00000592949EWSR1chr22

29687588

+ZNF444chr19

56670992

+
In-frameENST00000414183ENST00000592949EWSR1chr22

29683123

+ZNF444chr19

56670992

+
In-frameENST00000414183ENST00000592949EWSR1chr22

29687588

+ZNF444chr19

56670992

+
intron-3CDSENST00000331029ENST00000337080EWSR1chr22

29687588

+ZNF444chr19

56670992

+
intron-3CDSENST00000331029ENST00000592949EWSR1chr22

29687588

+ZNF444chr19

56670992

+
intron-3CDSENST00000332050ENST00000337080EWSR1chr22

29687588

+ZNF444chr19

56670992

+
intron-3CDSENST00000332050ENST00000592949EWSR1chr22

29687588

+ZNF444chr19

56670992

+
intron-3CDSENST00000333395ENST00000337080EWSR1chr22

29687588

+ZNF444chr19

56670992

+
intron-3CDSENST00000333395ENST00000592949EWSR1chr22

29687588

+ZNF444chr19

56670992

+
intron-3UTRENST00000331029ENST00000592171EWSR1chr22

29687588

+ZNF444chr19

56670992

+
intron-3UTRENST00000332050ENST00000592171EWSR1chr22

29687588

+ZNF444chr19

56670992

+
intron-3UTRENST00000333395ENST00000592171EWSR1chr22

29687588

+ZNF444chr19

56670992

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000332050EWSR1chr2229683123+ENST00000592949ZNF444chr1956670992+238811213281695455
ENST00000397938EWSR1chr2229683123+ENST00000592949ZNF444chr1956670992+237911123191686455
ENST00000406548EWSR1chr2229683123+ENST00000592949ZNF444chr1956670992+2124857641431455
ENST00000331029EWSR1chr2229683123+ENST00000592949ZNF444chr1956670992+2106839461413455
ENST00000414183EWSR1chr2229683123+ENST00000592949ZNF444chr1956670992+2099832211406461
ENST00000333395EWSR1chr2229683123+ENST00000592949ZNF444chr1956670992+2079812191386455
ENST00000332035EWSR1chr2229683123+ENST00000592949ZNF444chr1956670992+1903636111210399
ENST00000397938EWSR1chr2229687588+ENST00000592949ZNF444chr1956670992+259813313191905528
ENST00000406548EWSR1chr2229687588+ENST00000592949ZNF444chr1956670992+23401073641647527
ENST00000414183EWSR1chr2229687588+ENST00000592949ZNF444chr1956670992+23151048211622533
ENST00000332035EWSR1chr2229687588+ENST00000592949ZNF444chr1956670992+2122855111429472

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for EWSR1-ZNF444


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for EWSR1-ZNF444


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:/chr19:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EWSR1

Q01844

ZNF444

Q8N0Y2

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for EWSR1-ZNF444


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27861_27861_1_EWSR1-ZNF444_EWSR1_chr22_29683123_ENST00000331029_ZNF444_chr19_56670992_ENST00000592949_length(transcript)=2106nt_BP=839nt
GCGAGAGGGAGACGGACGTTGAGAGAACGAGGAGGAAGGAGAGAAAATGGCGTCCACGGATTACAGTACCTATAGCCAAGCTGCAGCGCA
GCAGGGCTACAGTGCTTACACCGCCCAGCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGG
ACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCCCAC
TGGTTATACTACTCCAACTGCCCCCCAGGCATACAGCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGATACCACCACTGCTACAGT
CACCACCACCCAGGCCTCCTATGCAGCTCAGTCTGCATATGGCACTCAGCCTGCTTATCCAGCCTATGGGCAGCAGCCAGCAGCCACTGC
ACCTACAAGACCGCAGGATGGAAACAAGCCCACTGAGACTAGTCAACCTCAATCTAGCACAGGGGGTTACAACCAGCCCAGCCTAGGATA
TGGACAGAGTAACTACAGTTATCCCCAGGTACCTGGGAGCTACCCCATGCAGCCAGTCACTGCACCTCCATCCTACCCTCCTACCAGCTA
TTCCTCTACACAGCCGACTAGTTATGATCAGAGCAGTTACTCTCAGCAGAACACCTATGGGCAACCGAGCAGCTATGGACAGCAGAGTAG
CTATGGTCAACAAAGCAGCTATGGGCAGCAGCCTCCCACTAGTTACCCACCCCAAACTGGATCCTACAGCCAAGCTCCAAGTCAATATAG
CCAACAGAGCAGCAGCTACGGGCAGCAGAGCACCGCCCCTGGGGCTGAGGGGCCGGCGCCTGGGGACTCCCAGGCTGTGCGCCCCTACAA
GCAGGAGCCCAGCAGCCCCCCGCTGGCGCCTGGCCTGCCCGCCTTCCTAGCGGCCCCGGGCACCACGTCCTGCCCCGAGTGCGGCAAAAC
GTCCCTGAAACCAGCTCACCTGCTGCGCCACCGGCAGAGCCACTCGGGCGAGAAGCCGCACGCCTGCCCTGAGTGCGGGAAGGCCTTTCG
GCGCAAGGAGCACCTGCGGCGCCACCGCGACACGCACCCCGGCAGCCCCGGCAGCCCCGGGCCCGCGCTGCGCCCTCTGCCCGCCCGTGA
GAAGCCCCACGCGTGCTGCGAGTGTGGCAAGACCTTCTACTGGCGCGAGCACCTGGTGCGCCACCGCAAGACGCACTCGGGAGCGCGGCC
CTTTGCCTGCTGGGAGTGTGGCAAGGGCTTCGGGCGCCGCGAGCACGTGCTGCGCCACCAGCGCATCCACGGCCGGGCAGCGGCCAGCGC
GCAGGGGGCGGTAGCTCCGGGCCCGGATGGTGGAGGCCCCTTCCCGCCCTGGCCCTTGGGTTAGCCGCCTCCCGGCCAGCGCCATCTCCC
GCCCTTGGTGCTGCCCCCGGGCGGTACCTGCTCTCTCCCAGCGCCACTTGGCCTCTTCCTCTCCTCCTTCCCTCCCATCGTCCTCCTCCA
CCTGCGCCTCCCTTGTCTGAACTTCCCAACGCCTTCCTATTCCTTTCCAACTCCTTTTCCCCCAAATTTCACTTTCCTTCTCAGGTCTCA
CCTCAGCCCCCCCCTTCTCCCTGATTTCTCGGCCTCTCTCTCTGTGTGAAGGGGCCTCTCCCTAATGTCTCCTCCTTCCCCCCTCTTCTC
TCTCCTGCGGCCCAGCCTCCCTCTCCCTCCTCCATTCCTCTCTCCCTGCCCTTTTCCTGCCTGAAGAGCAGAGGTGAGGACCTGGGACCC
CTGAGGGGCAGGCCAGGAGGAGCTCGGGCGCAGGCCAGGCCCCCTTGGTGAAGCAGAGGCTGAAGGAAAGGGGTCTGGGTCTTGTCCCTA
GGAATTCTCCTCCCTCAGGAGATTGGGGGTTGGGGGAGGCAGCGGGTGATGGCTCTGAAGCTGAACCCAGGGCCTGGCTGTGGTCTTCTT
GGTCTTGCTGCCCCCTGTGACCCAAAGGCATGGGATGGACAGAGATGCCTGCCCCCGTGAAGCTGGTTGGGGAGGGCAGTTCACCAGCAT
CCATAGAGTAATAAAGTCACTGTGTGTAGACCCGGA

>27861_27861_1_EWSR1-ZNF444_EWSR1_chr22_29683123_ENST00000331029_ZNF444_chr19_56670992_ENST00000592949_length(amino acids)=455AA_BP=328
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQSTAPGA
EGPAPGDSQAVRPYKQEPSSPPLAPGLPAFLAAPGTTSCPECGKTSLKPAHLLRHRQSHSGEKPHACPECGKAFRRKEHLRRHRDTHPGS
PGSPGPALRPLPAREKPHACCECGKTFYWREHLVRHRKTHSGARPFACWECGKGFGRREHVLRHQRIHGRAAASAQGAVAPGPDGGGPFP
PWPLG

--------------------------------------------------------------
>27861_27861_2_EWSR1-ZNF444_EWSR1_chr22_29683123_ENST00000332035_ZNF444_chr19_56670992_ENST00000592949_length(transcript)=1903nt_BP=636nt
AAGGAGAGAAAATGGCGTCCACGGATTACAGTACCTATAGCCAAGCTGCAGCGCAGCAGGGCTACAGTGCTTACACCGCCCAGCCCACTC
AAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGA
CCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCCCACTGGTTATACTACTCCAACTGCCCCCCAGGCATACA
GCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGATACCACCACTGCTACAGTCACCACCACCCAGGCCTCCTATGCAGCTCAGTCTG
CATATGGCACTCAGCCTGCTTATCCAGCCTATGGGCAGCAGCCAGCAGCCACTGCACCTACAAGCTATTCCTCTACACAGCCGACTAGTT
ATGATCAGAGCAGTTACTCTCAGCAGAACACCTATGGGCAACCGAGCAGCTATGGACAGCAGAGTAGCTATGGTCAACAAAGCAGCTATG
GGCAGCAGCCTCCCACTAGTTACCCACCCCAAACTGGATCCTACAGCCAAGCTCCAAGTCAATATAGCCAACAGAGCAGCAGCTACGGGC
AGCAGAGCACCGCCCCTGGGGCTGAGGGGCCGGCGCCTGGGGACTCCCAGGCTGTGCGCCCCTACAAGCAGGAGCCCAGCAGCCCCCCGC
TGGCGCCTGGCCTGCCCGCCTTCCTAGCGGCCCCGGGCACCACGTCCTGCCCCGAGTGCGGCAAAACGTCCCTGAAACCAGCTCACCTGC
TGCGCCACCGGCAGAGCCACTCGGGCGAGAAGCCGCACGCCTGCCCTGAGTGCGGGAAGGCCTTTCGGCGCAAGGAGCACCTGCGGCGCC
ACCGCGACACGCACCCCGGCAGCCCCGGCAGCCCCGGGCCCGCGCTGCGCCCTCTGCCCGCCCGTGAGAAGCCCCACGCGTGCTGCGAGT
GTGGCAAGACCTTCTACTGGCGCGAGCACCTGGTGCGCCACCGCAAGACGCACTCGGGAGCGCGGCCCTTTGCCTGCTGGGAGTGTGGCA
AGGGCTTCGGGCGCCGCGAGCACGTGCTGCGCCACCAGCGCATCCACGGCCGGGCAGCGGCCAGCGCGCAGGGGGCGGTAGCTCCGGGCC
CGGATGGTGGAGGCCCCTTCCCGCCCTGGCCCTTGGGTTAGCCGCCTCCCGGCCAGCGCCATCTCCCGCCCTTGGTGCTGCCCCCGGGCG
GTACCTGCTCTCTCCCAGCGCCACTTGGCCTCTTCCTCTCCTCCTTCCCTCCCATCGTCCTCCTCCACCTGCGCCTCCCTTGTCTGAACT
TCCCAACGCCTTCCTATTCCTTTCCAACTCCTTTTCCCCCAAATTTCACTTTCCTTCTCAGGTCTCACCTCAGCCCCCCCCTTCTCCCTG
ATTTCTCGGCCTCTCTCTCTGTGTGAAGGGGCCTCTCCCTAATGTCTCCTCCTTCCCCCCTCTTCTCTCTCCTGCGGCCCAGCCTCCCTC
TCCCTCCTCCATTCCTCTCTCCCTGCCCTTTTCCTGCCTGAAGAGCAGAGGTGAGGACCTGGGACCCCTGAGGGGCAGGCCAGGAGGAGC
TCGGGCGCAGGCCAGGCCCCCTTGGTGAAGCAGAGGCTGAAGGAAAGGGGTCTGGGTCTTGTCCCTAGGAATTCTCCTCCCTCAGGAGAT
TGGGGGTTGGGGGAGGCAGCGGGTGATGGCTCTGAAGCTGAACCCAGGGCCTGGCTGTGGTCTTCTTGGTCTTGCTGCCCCCTGTGACCC
AAAGGCATGGGATGGACAGAGATGCCTGCCCCCGTGAAGCTGGTTGGGGAGGGCAGTTCACCAGCATCCATAGAGTAATAAAGTCACTGT
GTGTAGACCCGGA

>27861_27861_2_EWSR1-ZNF444_EWSR1_chr22_29683123_ENST00000332035_ZNF444_chr19_56670992_ENST00000592949_length(amino acids)=399AA_BP=272
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQP
PTSYPPQTGSYSQAPSQYSQQSSSYGQQSTAPGAEGPAPGDSQAVRPYKQEPSSPPLAPGLPAFLAAPGTTSCPECGKTSLKPAHLLRHR
QSHSGEKPHACPECGKAFRRKEHLRRHRDTHPGSPGSPGPALRPLPAREKPHACCECGKTFYWREHLVRHRKTHSGARPFACWECGKGFG
RREHVLRHQRIHGRAAASAQGAVAPGPDGGGPFPPWPLG

--------------------------------------------------------------
>27861_27861_3_EWSR1-ZNF444_EWSR1_chr22_29683123_ENST00000332050_ZNF444_chr19_56670992_ENST00000592949_length(transcript)=2388nt_BP=1121nt
AGAGCCAGCGGACGGAACCATTCCAAACAGCCTAGTCTCGTGCTGAGAGCCTCTCCGGTTTCACGCTGAGACCCGCTCACCCCCGCTCTG
GCCCCTTAGATGCTATTTTGGCCCGAGTGTCACGTCGGGCGCTCTTTAGAGAGGACTGGGACAAGAGTTGCGGACGCGAAGAACGAGTAA
GCGGTGGTTCATCCCTCCTGACCCCACCCCCGTGGCCTGGCCCGATGGTCGCGCCCGGGGTTGCGAGATTTGCGCCTGCGCAGTGCGGCG
CCTAGAGGGAAAGCGAGAGGGAGACGGACGTTGAGAGAACGAGGAGGAAGGAGAGAAAATGGCGTCCACGGATTACAGTACCTATAGCCA
AGCTGCAGCGCAGCAGGGCTACAGTGCTTACACCGCCCAGCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTA
TGGAACCTATGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGG
ACAGCCTCCCACTGGTTATACTACTCCAACTGCCCCCCAGGCATACAGCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGATACCAC
CACTGCTACAGTCACCACCACCCAGGCCTCCTATGCAGCTCAGTCTGCATATGGCACTCAGCCTGCTTATCCAGCCTATGGGCAGCAGCC
AGCAGCCACTGCACCTACAAGACCGCAGGATGGAAACAAGCCCACTGAGACTAGTCAACCTCAATCTAGCACAGGGGGTTACAACCAGCC
CAGCCTAGGATATGGACAGAGTAACTACAGTTATCCCCAGGTACCTGGGAGCTACCCCATGCAGCCAGTCACTGCACCTCCATCCTACCC
TCCTACCAGCTATTCCTCTACACAGCCGACTAGTTATGATCAGAGCAGTTACTCTCAGCAGAACACCTATGGGCAACCGAGCAGCTATGG
ACAGCAGAGTAGCTATGGTCAACAAAGCAGCTATGGGCAGCAGCCTCCCACTAGTTACCCACCCCAAACTGGATCCTACAGCCAAGCTCC
AAGTCAATATAGCCAACAGAGCAGCAGCTACGGGCAGCAGAGCACCGCCCCTGGGGCTGAGGGGCCGGCGCCTGGGGACTCCCAGGCTGT
GCGCCCCTACAAGCAGGAGCCCAGCAGCCCCCCGCTGGCGCCTGGCCTGCCCGCCTTCCTAGCGGCCCCGGGCACCACGTCCTGCCCCGA
GTGCGGCAAAACGTCCCTGAAACCAGCTCACCTGCTGCGCCACCGGCAGAGCCACTCGGGCGAGAAGCCGCACGCCTGCCCTGAGTGCGG
GAAGGCCTTTCGGCGCAAGGAGCACCTGCGGCGCCACCGCGACACGCACCCCGGCAGCCCCGGCAGCCCCGGGCCCGCGCTGCGCCCTCT
GCCCGCCCGTGAGAAGCCCCACGCGTGCTGCGAGTGTGGCAAGACCTTCTACTGGCGCGAGCACCTGGTGCGCCACCGCAAGACGCACTC
GGGAGCGCGGCCCTTTGCCTGCTGGGAGTGTGGCAAGGGCTTCGGGCGCCGCGAGCACGTGCTGCGCCACCAGCGCATCCACGGCCGGGC
AGCGGCCAGCGCGCAGGGGGCGGTAGCTCCGGGCCCGGATGGTGGAGGCCCCTTCCCGCCCTGGCCCTTGGGTTAGCCGCCTCCCGGCCA
GCGCCATCTCCCGCCCTTGGTGCTGCCCCCGGGCGGTACCTGCTCTCTCCCAGCGCCACTTGGCCTCTTCCTCTCCTCCTTCCCTCCCAT
CGTCCTCCTCCACCTGCGCCTCCCTTGTCTGAACTTCCCAACGCCTTCCTATTCCTTTCCAACTCCTTTTCCCCCAAATTTCACTTTCCT
TCTCAGGTCTCACCTCAGCCCCCCCCTTCTCCCTGATTTCTCGGCCTCTCTCTCTGTGTGAAGGGGCCTCTCCCTAATGTCTCCTCCTTC
CCCCCTCTTCTCTCTCCTGCGGCCCAGCCTCCCTCTCCCTCCTCCATTCCTCTCTCCCTGCCCTTTTCCTGCCTGAAGAGCAGAGGTGAG
GACCTGGGACCCCTGAGGGGCAGGCCAGGAGGAGCTCGGGCGCAGGCCAGGCCCCCTTGGTGAAGCAGAGGCTGAAGGAAAGGGGTCTGG
GTCTTGTCCCTAGGAATTCTCCTCCCTCAGGAGATTGGGGGTTGGGGGAGGCAGCGGGTGATGGCTCTGAAGCTGAACCCAGGGCCTGGC
TGTGGTCTTCTTGGTCTTGCTGCCCCCTGTGACCCAAAGGCATGGGATGGACAGAGATGCCTGCCCCCGTGAAGCTGGTTGGGGAGGGCA
GTTCACCAGCATCCATAGAGTAATAAAGTCACTGTGTGTAGACCCGGA

>27861_27861_3_EWSR1-ZNF444_EWSR1_chr22_29683123_ENST00000332050_ZNF444_chr19_56670992_ENST00000592949_length(amino acids)=455AA_BP=328
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQSTAPGA
EGPAPGDSQAVRPYKQEPSSPPLAPGLPAFLAAPGTTSCPECGKTSLKPAHLLRHRQSHSGEKPHACPECGKAFRRKEHLRRHRDTHPGS
PGSPGPALRPLPAREKPHACCECGKTFYWREHLVRHRKTHSGARPFACWECGKGFGRREHVLRHQRIHGRAAASAQGAVAPGPDGGGPFP
PWPLG

--------------------------------------------------------------
>27861_27861_4_EWSR1-ZNF444_EWSR1_chr22_29683123_ENST00000333395_ZNF444_chr19_56670992_ENST00000592949_length(transcript)=2079nt_BP=812nt
CGAGGAGGAAGGAGAGAAAATGGCGTCCACGGATTACAGTACCTATAGCCAAGCTGCAGCGCAGCAGGGCTACAGTGCTTACACCGCCCA
GCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACCCA
GGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCCCACTGGTTATACTACTCCAACTGCCCCCCA
GGCATACAGCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGATACCACCACTGCTACAGTCACCACCACCCAGGCCTCCTATGCAGC
TCAGTCTGCATATGGCACTCAGCCTGCTTATCCAGCCTATGGGCAGCAGCCAGCAGCCACTGCACCTACAAGACCGCAGGATGGAAACAA
GCCCACTGAGACTAGTCAACCTCAATCTAGCACAGGGGGTTACAACCAGCCCAGCCTAGGATATGGACAGAGTAACTACAGTTATCCCCA
GGTACCTGGGAGCTACCCCATGCAGCCAGTCACTGCACCTCCATCCTACCCTCCTACCAGCTATTCCTCTACACAGCCGACTAGTTATGA
TCAGAGCAGTTACTCTCAGCAGAACACCTATGGGCAACCGAGCAGCTATGGACAGCAGAGTAGCTATGGTCAACAAAGCAGCTATGGGCA
GCAGCCTCCCACTAGTTACCCACCCCAAACTGGATCCTACAGCCAAGCTCCAAGTCAATATAGCCAACAGAGCAGCAGCTACGGGCAGCA
GAGCACCGCCCCTGGGGCTGAGGGGCCGGCGCCTGGGGACTCCCAGGCTGTGCGCCCCTACAAGCAGGAGCCCAGCAGCCCCCCGCTGGC
GCCTGGCCTGCCCGCCTTCCTAGCGGCCCCGGGCACCACGTCCTGCCCCGAGTGCGGCAAAACGTCCCTGAAACCAGCTCACCTGCTGCG
CCACCGGCAGAGCCACTCGGGCGAGAAGCCGCACGCCTGCCCTGAGTGCGGGAAGGCCTTTCGGCGCAAGGAGCACCTGCGGCGCCACCG
CGACACGCACCCCGGCAGCCCCGGCAGCCCCGGGCCCGCGCTGCGCCCTCTGCCCGCCCGTGAGAAGCCCCACGCGTGCTGCGAGTGTGG
CAAGACCTTCTACTGGCGCGAGCACCTGGTGCGCCACCGCAAGACGCACTCGGGAGCGCGGCCCTTTGCCTGCTGGGAGTGTGGCAAGGG
CTTCGGGCGCCGCGAGCACGTGCTGCGCCACCAGCGCATCCACGGCCGGGCAGCGGCCAGCGCGCAGGGGGCGGTAGCTCCGGGCCCGGA
TGGTGGAGGCCCCTTCCCGCCCTGGCCCTTGGGTTAGCCGCCTCCCGGCCAGCGCCATCTCCCGCCCTTGGTGCTGCCCCCGGGCGGTAC
CTGCTCTCTCCCAGCGCCACTTGGCCTCTTCCTCTCCTCCTTCCCTCCCATCGTCCTCCTCCACCTGCGCCTCCCTTGTCTGAACTTCCC
AACGCCTTCCTATTCCTTTCCAACTCCTTTTCCCCCAAATTTCACTTTCCTTCTCAGGTCTCACCTCAGCCCCCCCCTTCTCCCTGATTT
CTCGGCCTCTCTCTCTGTGTGAAGGGGCCTCTCCCTAATGTCTCCTCCTTCCCCCCTCTTCTCTCTCCTGCGGCCCAGCCTCCCTCTCCC
TCCTCCATTCCTCTCTCCCTGCCCTTTTCCTGCCTGAAGAGCAGAGGTGAGGACCTGGGACCCCTGAGGGGCAGGCCAGGAGGAGCTCGG
GCGCAGGCCAGGCCCCCTTGGTGAAGCAGAGGCTGAAGGAAAGGGGTCTGGGTCTTGTCCCTAGGAATTCTCCTCCCTCAGGAGATTGGG
GGTTGGGGGAGGCAGCGGGTGATGGCTCTGAAGCTGAACCCAGGGCCTGGCTGTGGTCTTCTTGGTCTTGCTGCCCCCTGTGACCCAAAG
GCATGGGATGGACAGAGATGCCTGCCCCCGTGAAGCTGGTTGGGGAGGGCAGTTCACCAGCATCCATAGAGTAATAAAGTCACTGTGTGT
AGACCCGGA

>27861_27861_4_EWSR1-ZNF444_EWSR1_chr22_29683123_ENST00000333395_ZNF444_chr19_56670992_ENST00000592949_length(amino acids)=455AA_BP=328
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQSTAPGA
EGPAPGDSQAVRPYKQEPSSPPLAPGLPAFLAAPGTTSCPECGKTSLKPAHLLRHRQSHSGEKPHACPECGKAFRRKEHLRRHRDTHPGS
PGSPGPALRPLPAREKPHACCECGKTFYWREHLVRHRKTHSGARPFACWECGKGFGRREHVLRHQRIHGRAAASAQGAVAPGPDGGGPFP
PWPLG

--------------------------------------------------------------
>27861_27861_5_EWSR1-ZNF444_EWSR1_chr22_29683123_ENST00000397938_ZNF444_chr19_56670992_ENST00000592949_length(transcript)=2379nt_BP=1112nt
GGACGGAACCATTCCAAACAGCCTAGTCTCGTGCTGAGAGCCTCTCCGGTTTCACGCTGAGACCCGCTCACCCCCGCTCTGGCCCCTTAG
ATGCTATTTTGGCCCGAGTGTCACGTCGGGCGCTCTTTAGAGAGGACTGGGACAAGAGTTGCGGACGCGAAGAACGAGTAAGCGGTGGTT
CATCCCTCCTGACCCCACCCCCGTGGCCTGGCCCGATGGTCGCGCCCGGGGTTGCGAGATTTGCGCCTGCGCAGTGCGGCGCCTAGAGGG
AAAGCGAGAGGGAGACGGACGTTGAGAGAACGAGGAGGAAGGAGAGAAAATGGCGTCCACGGATTACAGTACCTATAGCCAAGCTGCAGC
GCAGCAGGGCTACAGTGCTTACACCGCCCAGCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTA
TGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCC
CACTGGTTATACTACTCCAACTGCCCCCCAGGCATACAGCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGATACCACCACTGCTAC
AGTCACCACCACCCAGGCCTCCTATGCAGCTCAGTCTGCATATGGCACTCAGCCTGCTTATCCAGCCTATGGGCAGCAGCCAGCAGCCAC
TGCACCTACAAGACCGCAGGATGGAAACAAGCCCACTGAGACTAGTCAACCTCAATCTAGCACAGGGGGTTACAACCAGCCCAGCCTAGG
ATATGGACAGAGTAACTACAGTTATCCCCAGGTACCTGGGAGCTACCCCATGCAGCCAGTCACTGCACCTCCATCCTACCCTCCTACCAG
CTATTCCTCTACACAGCCGACTAGTTATGATCAGAGCAGTTACTCTCAGCAGAACACCTATGGGCAACCGAGCAGCTATGGACAGCAGAG
TAGCTATGGTCAACAAAGCAGCTATGGGCAGCAGCCTCCCACTAGTTACCCACCCCAAACTGGATCCTACAGCCAAGCTCCAAGTCAATA
TAGCCAACAGAGCAGCAGCTACGGGCAGCAGAGCACCGCCCCTGGGGCTGAGGGGCCGGCGCCTGGGGACTCCCAGGCTGTGCGCCCCTA
CAAGCAGGAGCCCAGCAGCCCCCCGCTGGCGCCTGGCCTGCCCGCCTTCCTAGCGGCCCCGGGCACCACGTCCTGCCCCGAGTGCGGCAA
AACGTCCCTGAAACCAGCTCACCTGCTGCGCCACCGGCAGAGCCACTCGGGCGAGAAGCCGCACGCCTGCCCTGAGTGCGGGAAGGCCTT
TCGGCGCAAGGAGCACCTGCGGCGCCACCGCGACACGCACCCCGGCAGCCCCGGCAGCCCCGGGCCCGCGCTGCGCCCTCTGCCCGCCCG
TGAGAAGCCCCACGCGTGCTGCGAGTGTGGCAAGACCTTCTACTGGCGCGAGCACCTGGTGCGCCACCGCAAGACGCACTCGGGAGCGCG
GCCCTTTGCCTGCTGGGAGTGTGGCAAGGGCTTCGGGCGCCGCGAGCACGTGCTGCGCCACCAGCGCATCCACGGCCGGGCAGCGGCCAG
CGCGCAGGGGGCGGTAGCTCCGGGCCCGGATGGTGGAGGCCCCTTCCCGCCCTGGCCCTTGGGTTAGCCGCCTCCCGGCCAGCGCCATCT
CCCGCCCTTGGTGCTGCCCCCGGGCGGTACCTGCTCTCTCCCAGCGCCACTTGGCCTCTTCCTCTCCTCCTTCCCTCCCATCGTCCTCCT
CCACCTGCGCCTCCCTTGTCTGAACTTCCCAACGCCTTCCTATTCCTTTCCAACTCCTTTTCCCCCAAATTTCACTTTCCTTCTCAGGTC
TCACCTCAGCCCCCCCCTTCTCCCTGATTTCTCGGCCTCTCTCTCTGTGTGAAGGGGCCTCTCCCTAATGTCTCCTCCTTCCCCCCTCTT
CTCTCTCCTGCGGCCCAGCCTCCCTCTCCCTCCTCCATTCCTCTCTCCCTGCCCTTTTCCTGCCTGAAGAGCAGAGGTGAGGACCTGGGA
CCCCTGAGGGGCAGGCCAGGAGGAGCTCGGGCGCAGGCCAGGCCCCCTTGGTGAAGCAGAGGCTGAAGGAAAGGGGTCTGGGTCTTGTCC
CTAGGAATTCTCCTCCCTCAGGAGATTGGGGGTTGGGGGAGGCAGCGGGTGATGGCTCTGAAGCTGAACCCAGGGCCTGGCTGTGGTCTT
CTTGGTCTTGCTGCCCCCTGTGACCCAAAGGCATGGGATGGACAGAGATGCCTGCCCCCGTGAAGCTGGTTGGGGAGGGCAGTTCACCAG
CATCCATAGAGTAATAAAGTCACTGTGTGTAGACCCGGA

>27861_27861_5_EWSR1-ZNF444_EWSR1_chr22_29683123_ENST00000397938_ZNF444_chr19_56670992_ENST00000592949_length(amino acids)=455AA_BP=328
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQSTAPGA
EGPAPGDSQAVRPYKQEPSSPPLAPGLPAFLAAPGTTSCPECGKTSLKPAHLLRHRQSHSGEKPHACPECGKAFRRKEHLRRHRDTHPGS
PGSPGPALRPLPAREKPHACCECGKTFYWREHLVRHRKTHSGARPFACWECGKGFGRREHVLRHQRIHGRAAASAQGAVAPGPDGGGPFP
PWPLG

--------------------------------------------------------------
>27861_27861_6_EWSR1-ZNF444_EWSR1_chr22_29683123_ENST00000406548_ZNF444_chr19_56670992_ENST00000592949_length(transcript)=2124nt_BP=857nt
GCGGCGCCTAGAGGGAAAGCGAGAGGGAGACGGACGTTGAGAGAACGAGGAGGAAGGAGAGAAAATGGCGTCCACGGATTACAGTACCTA
TAGCCAAGCTGCAGCGCAGCAGGGCTACAGTGCTTACACCGCCCAGCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACA
AAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACTTC
TTATGGACAGCCTCCCACTGGTTATACTACTCCAACTGCCCCCCAGGCATACAGCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGA
TACCACCACTGCTACAGTCACCACCACCCAGGCCTCCTATGCAGCTCAGTCTGCATATGGCACTCAGCCTGCTTATCCAGCCTATGGGCA
GCAGCCAGCAGCCACTGCACCTACAAGACCGCAGGATGGAAACAAGCCCACTGAGACTAGTCAACCTCAATCTAGCACAGGGGGTTACAA
CCAGCCCAGCCTAGGATATGGACAGAGTAACTACAGTTATCCCCAGGTACCTGGGAGCTACCCCATGCAGCCAGTCACTGCACCTCCATC
CTACCCTCCTACCAGCTATTCCTCTACACAGCCGACTAGTTATGATCAGAGCAGTTACTCTCAGCAGAACACCTATGGGCAACCGAGCAG
CTATGGACAGCAGAGTAGCTATGGTCAACAAAGCAGCTATGGGCAGCAGCCTCCCACTAGTTACCCACCCCAAACTGGATCCTACAGCCA
AGCTCCAAGTCAATATAGCCAACAGAGCAGCAGCTACGGGCAGCAGAGCACCGCCCCTGGGGCTGAGGGGCCGGCGCCTGGGGACTCCCA
GGCTGTGCGCCCCTACAAGCAGGAGCCCAGCAGCCCCCCGCTGGCGCCTGGCCTGCCCGCCTTCCTAGCGGCCCCGGGCACCACGTCCTG
CCCCGAGTGCGGCAAAACGTCCCTGAAACCAGCTCACCTGCTGCGCCACCGGCAGAGCCACTCGGGCGAGAAGCCGCACGCCTGCCCTGA
GTGCGGGAAGGCCTTTCGGCGCAAGGAGCACCTGCGGCGCCACCGCGACACGCACCCCGGCAGCCCCGGCAGCCCCGGGCCCGCGCTGCG
CCCTCTGCCCGCCCGTGAGAAGCCCCACGCGTGCTGCGAGTGTGGCAAGACCTTCTACTGGCGCGAGCACCTGGTGCGCCACCGCAAGAC
GCACTCGGGAGCGCGGCCCTTTGCCTGCTGGGAGTGTGGCAAGGGCTTCGGGCGCCGCGAGCACGTGCTGCGCCACCAGCGCATCCACGG
CCGGGCAGCGGCCAGCGCGCAGGGGGCGGTAGCTCCGGGCCCGGATGGTGGAGGCCCCTTCCCGCCCTGGCCCTTGGGTTAGCCGCCTCC
CGGCCAGCGCCATCTCCCGCCCTTGGTGCTGCCCCCGGGCGGTACCTGCTCTCTCCCAGCGCCACTTGGCCTCTTCCTCTCCTCCTTCCC
TCCCATCGTCCTCCTCCACCTGCGCCTCCCTTGTCTGAACTTCCCAACGCCTTCCTATTCCTTTCCAACTCCTTTTCCCCCAAATTTCAC
TTTCCTTCTCAGGTCTCACCTCAGCCCCCCCCTTCTCCCTGATTTCTCGGCCTCTCTCTCTGTGTGAAGGGGCCTCTCCCTAATGTCTCC
TCCTTCCCCCCTCTTCTCTCTCCTGCGGCCCAGCCTCCCTCTCCCTCCTCCATTCCTCTCTCCCTGCCCTTTTCCTGCCTGAAGAGCAGA
GGTGAGGACCTGGGACCCCTGAGGGGCAGGCCAGGAGGAGCTCGGGCGCAGGCCAGGCCCCCTTGGTGAAGCAGAGGCTGAAGGAAAGGG
GTCTGGGTCTTGTCCCTAGGAATTCTCCTCCCTCAGGAGATTGGGGGTTGGGGGAGGCAGCGGGTGATGGCTCTGAAGCTGAACCCAGGG
CCTGGCTGTGGTCTTCTTGGTCTTGCTGCCCCCTGTGACCCAAAGGCATGGGATGGACAGAGATGCCTGCCCCCGTGAAGCTGGTTGGGG
AGGGCAGTTCACCAGCATCCATAGAGTAATAAAGTCACTGTGTGTAGACCCGGA

>27861_27861_6_EWSR1-ZNF444_EWSR1_chr22_29683123_ENST00000406548_ZNF444_chr19_56670992_ENST00000592949_length(amino acids)=455AA_BP=328
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQSTAPGA
EGPAPGDSQAVRPYKQEPSSPPLAPGLPAFLAAPGTTSCPECGKTSLKPAHLLRHRQSHSGEKPHACPECGKAFRRKEHLRRHRDTHPGS
PGSPGPALRPLPAREKPHACCECGKTFYWREHLVRHRKTHSGARPFACWECGKGFGRREHVLRHQRIHGRAAASAQGAVAPGPDGGGPFP
PWPLG

--------------------------------------------------------------
>27861_27861_7_EWSR1-ZNF444_EWSR1_chr22_29683123_ENST00000414183_ZNF444_chr19_56670992_ENST00000592949_length(transcript)=2099nt_BP=832nt
AACGAGGAGGAAGGAGAGAAAATGGCGTCCACGGATTACAGTACCTATAGCCAAGCTGCAGCGCAGCAGGGCTACAGTGCTTACACCGCC
CAGCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACC
CAGGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCCCACTGTAGAAGGGACCAGTACAGGTTAT
ACTACTCCAACTGCCCCCCAGGCATACAGCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGATACCACCACTGCTACAGTCACCACC
ACCCAGGCCTCCTATGCAGCTCAGTCTGCATATGGCACTCAGCCTGCTTATCCAGCCTATGGGCAGCAGCCAGCAGCCACTGCACCTACA
AGACCGCAGGATGGAAACAAGCCCACTGAGACTAGTCAACCTCAATCTAGCACAGGGGGTTACAACCAGCCCAGCCTAGGATATGGACAG
AGTAACTACAGTTATCCCCAGGTACCTGGGAGCTACCCCATGCAGCCAGTCACTGCACCTCCATCCTACCCTCCTACCAGCTATTCCTCT
ACACAGCCGACTAGTTATGATCAGAGCAGTTACTCTCAGCAGAACACCTATGGGCAACCGAGCAGCTATGGACAGCAGAGTAGCTATGGT
CAACAAAGCAGCTATGGGCAGCAGCCTCCCACTAGTTACCCACCCCAAACTGGATCCTACAGCCAAGCTCCAAGTCAATATAGCCAACAG
AGCAGCAGCTACGGGCAGCAGAGCACCGCCCCTGGGGCTGAGGGGCCGGCGCCTGGGGACTCCCAGGCTGTGCGCCCCTACAAGCAGGAG
CCCAGCAGCCCCCCGCTGGCGCCTGGCCTGCCCGCCTTCCTAGCGGCCCCGGGCACCACGTCCTGCCCCGAGTGCGGCAAAACGTCCCTG
AAACCAGCTCACCTGCTGCGCCACCGGCAGAGCCACTCGGGCGAGAAGCCGCACGCCTGCCCTGAGTGCGGGAAGGCCTTTCGGCGCAAG
GAGCACCTGCGGCGCCACCGCGACACGCACCCCGGCAGCCCCGGCAGCCCCGGGCCCGCGCTGCGCCCTCTGCCCGCCCGTGAGAAGCCC
CACGCGTGCTGCGAGTGTGGCAAGACCTTCTACTGGCGCGAGCACCTGGTGCGCCACCGCAAGACGCACTCGGGAGCGCGGCCCTTTGCC
TGCTGGGAGTGTGGCAAGGGCTTCGGGCGCCGCGAGCACGTGCTGCGCCACCAGCGCATCCACGGCCGGGCAGCGGCCAGCGCGCAGGGG
GCGGTAGCTCCGGGCCCGGATGGTGGAGGCCCCTTCCCGCCCTGGCCCTTGGGTTAGCCGCCTCCCGGCCAGCGCCATCTCCCGCCCTTG
GTGCTGCCCCCGGGCGGTACCTGCTCTCTCCCAGCGCCACTTGGCCTCTTCCTCTCCTCCTTCCCTCCCATCGTCCTCCTCCACCTGCGC
CTCCCTTGTCTGAACTTCCCAACGCCTTCCTATTCCTTTCCAACTCCTTTTCCCCCAAATTTCACTTTCCTTCTCAGGTCTCACCTCAGC
CCCCCCCTTCTCCCTGATTTCTCGGCCTCTCTCTCTGTGTGAAGGGGCCTCTCCCTAATGTCTCCTCCTTCCCCCCTCTTCTCTCTCCTG
CGGCCCAGCCTCCCTCTCCCTCCTCCATTCCTCTCTCCCTGCCCTTTTCCTGCCTGAAGAGCAGAGGTGAGGACCTGGGACCCCTGAGGG
GCAGGCCAGGAGGAGCTCGGGCGCAGGCCAGGCCCCCTTGGTGAAGCAGAGGCTGAAGGAAAGGGGTCTGGGTCTTGTCCCTAGGAATTC
TCCTCCCTCAGGAGATTGGGGGTTGGGGGAGGCAGCGGGTGATGGCTCTGAAGCTGAACCCAGGGCCTGGCTGTGGTCTTCTTGGTCTTG
CTGCCCCCTGTGACCCAAAGGCATGGGATGGACAGAGATGCCTGCCCCCGTGAAGCTGGTTGGGGAGGGCAGTTCACCAGCATCCATAGA
GTAATAAAGTCACTGTGTGTAGACCCGGA

>27861_27861_7_EWSR1-ZNF444_EWSR1_chr22_29683123_ENST00000414183_ZNF444_chr19_56670992_ENST00000592949_length(amino acids)=461AA_BP=334
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTVEGTSTGYTTPTAPQ
AYSQPVQGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQ
VPGSYPMQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQ
STAPGAEGPAPGDSQAVRPYKQEPSSPPLAPGLPAFLAAPGTTSCPECGKTSLKPAHLLRHRQSHSGEKPHACPECGKAFRRKEHLRRHR
DTHPGSPGSPGPALRPLPAREKPHACCECGKTFYWREHLVRHRKTHSGARPFACWECGKGFGRREHVLRHQRIHGRAAASAQGAVAPGPD
GGGPFPPWPLG

--------------------------------------------------------------
>27861_27861_8_EWSR1-ZNF444_EWSR1_chr22_29687588_ENST00000332035_ZNF444_chr19_56670992_ENST00000592949_length(transcript)=2122nt_BP=855nt
AAGGAGAGAAAATGGCGTCCACGGATTACAGTACCTATAGCCAAGCTGCAGCGCAGCAGGGCTACAGTGCTTACACCGCCCAGCCCACTC
AAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGA
CCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCCCACTGGTTATACTACTCCAACTGCCCCCCAGGCATACA
GCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGATACCACCACTGCTACAGTCACCACCACCCAGGCCTCCTATGCAGCTCAGTCTG
CATATGGCACTCAGCCTGCTTATCCAGCCTATGGGCAGCAGCCAGCAGCCACTGCACCTACAAGCTATTCCTCTACACAGCCGACTAGTT
ATGATCAGAGCAGTTACTCTCAGCAGAACACCTATGGGCAACCGAGCAGCTATGGACAGCAGAGTAGCTATGGTCAACAAAGCAGCTATG
GGCAGCAGCCTCCCACTAGTTACCCACCCCAAACTGGATCCTACAGCCAAGCTCCAAGTCAATATAGCCAACAGAGCAGCAGCTACGGGC
AGCAGAGTTCATTCCGACAGGACCACCCCAGTAGCATGGGTGTTTATGGGCAGGAGTCTGGAGGATTTTCCGGACCAGGAGAGAACCGGA
GCATGAGTGGCCCTGATAACCGGGGCAGGGGAAGAGGGGGATTTGATCGTGGAGGCATGAGCAGAGGTGGGCGGGGAGGAGGACGCGGTG
GAATGGGCAGCGCTGGAGAGCGAGGTGGCTTCAATAAGCCTGGTGGCACCGCCCCTGGGGCTGAGGGGCCGGCGCCTGGGGACTCCCAGG
CTGTGCGCCCCTACAAGCAGGAGCCCAGCAGCCCCCCGCTGGCGCCTGGCCTGCCCGCCTTCCTAGCGGCCCCGGGCACCACGTCCTGCC
CCGAGTGCGGCAAAACGTCCCTGAAACCAGCTCACCTGCTGCGCCACCGGCAGAGCCACTCGGGCGAGAAGCCGCACGCCTGCCCTGAGT
GCGGGAAGGCCTTTCGGCGCAAGGAGCACCTGCGGCGCCACCGCGACACGCACCCCGGCAGCCCCGGCAGCCCCGGGCCCGCGCTGCGCC
CTCTGCCCGCCCGTGAGAAGCCCCACGCGTGCTGCGAGTGTGGCAAGACCTTCTACTGGCGCGAGCACCTGGTGCGCCACCGCAAGACGC
ACTCGGGAGCGCGGCCCTTTGCCTGCTGGGAGTGTGGCAAGGGCTTCGGGCGCCGCGAGCACGTGCTGCGCCACCAGCGCATCCACGGCC
GGGCAGCGGCCAGCGCGCAGGGGGCGGTAGCTCCGGGCCCGGATGGTGGAGGCCCCTTCCCGCCCTGGCCCTTGGGTTAGCCGCCTCCCG
GCCAGCGCCATCTCCCGCCCTTGGTGCTGCCCCCGGGCGGTACCTGCTCTCTCCCAGCGCCACTTGGCCTCTTCCTCTCCTCCTTCCCTC
CCATCGTCCTCCTCCACCTGCGCCTCCCTTGTCTGAACTTCCCAACGCCTTCCTATTCCTTTCCAACTCCTTTTCCCCCAAATTTCACTT
TCCTTCTCAGGTCTCACCTCAGCCCCCCCCTTCTCCCTGATTTCTCGGCCTCTCTCTCTGTGTGAAGGGGCCTCTCCCTAATGTCTCCTC
CTTCCCCCCTCTTCTCTCTCCTGCGGCCCAGCCTCCCTCTCCCTCCTCCATTCCTCTCTCCCTGCCCTTTTCCTGCCTGAAGAGCAGAGG
TGAGGACCTGGGACCCCTGAGGGGCAGGCCAGGAGGAGCTCGGGCGCAGGCCAGGCCCCCTTGGTGAAGCAGAGGCTGAAGGAAAGGGGT
CTGGGTCTTGTCCCTAGGAATTCTCCTCCCTCAGGAGATTGGGGGTTGGGGGAGGCAGCGGGTGATGGCTCTGAAGCTGAACCCAGGGCC
TGGCTGTGGTCTTCTTGGTCTTGCTGCCCCCTGTGACCCAAAGGCATGGGATGGACAGAGATGCCTGCCCCCGTGAAGCTGGTTGGGGAG
GGCAGTTCACCAGCATCCATAGAGTAATAAAGTCACTGTGTGTAGACCCGGA

>27861_27861_8_EWSR1-ZNF444_EWSR1_chr22_29687588_ENST00000332035_ZNF444_chr19_56670992_ENST00000592949_length(amino acids)=472AA_BP=345
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQP
PTSYPPQTGSYSQAPSQYSQQSSSYGQQSSFRQDHPSSMGVYGQESGGFSGPGENRSMSGPDNRGRGRGGFDRGGMSRGGRGGGRGGMGS
AGERGGFNKPGGTAPGAEGPAPGDSQAVRPYKQEPSSPPLAPGLPAFLAAPGTTSCPECGKTSLKPAHLLRHRQSHSGEKPHACPECGKA
FRRKEHLRRHRDTHPGSPGSPGPALRPLPAREKPHACCECGKTFYWREHLVRHRKTHSGARPFACWECGKGFGRREHVLRHQRIHGRAAA
SAQGAVAPGPDGGGPFPPWPLG

--------------------------------------------------------------
>27861_27861_9_EWSR1-ZNF444_EWSR1_chr22_29687588_ENST00000397938_ZNF444_chr19_56670992_ENST00000592949_length(transcript)=2598nt_BP=1331nt
GGACGGAACCATTCCAAACAGCCTAGTCTCGTGCTGAGAGCCTCTCCGGTTTCACGCTGAGACCCGCTCACCCCCGCTCTGGCCCCTTAG
ATGCTATTTTGGCCCGAGTGTCACGTCGGGCGCTCTTTAGAGAGGACTGGGACAAGAGTTGCGGACGCGAAGAACGAGTAAGCGGTGGTT
CATCCCTCCTGACCCCACCCCCGTGGCCTGGCCCGATGGTCGCGCCCGGGGTTGCGAGATTTGCGCCTGCGCAGTGCGGCGCCTAGAGGG
AAAGCGAGAGGGAGACGGACGTTGAGAGAACGAGGAGGAAGGAGAGAAAATGGCGTCCACGGATTACAGTACCTATAGCCAAGCTGCAGC
GCAGCAGGGCTACAGTGCTTACACCGCCCAGCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTA
TGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCC
CACTGGTTATACTACTCCAACTGCCCCCCAGGCATACAGCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGATACCACCACTGCTAC
AGTCACCACCACCCAGGCCTCCTATGCAGCTCAGTCTGCATATGGCACTCAGCCTGCTTATCCAGCCTATGGGCAGCAGCCAGCAGCCAC
TGCACCTACAAGACCGCAGGATGGAAACAAGCCCACTGAGACTAGTCAACCTCAATCTAGCACAGGGGGTTACAACCAGCCCAGCCTAGG
ATATGGACAGAGTAACTACAGTTATCCCCAGGTACCTGGGAGCTACCCCATGCAGCCAGTCACTGCACCTCCATCCTACCCTCCTACCAG
CTATTCCTCTACACAGCCGACTAGTTATGATCAGAGCAGTTACTCTCAGCAGAACACCTATGGGCAACCGAGCAGCTATGGACAGCAGAG
TAGCTATGGTCAACAAAGCAGCTATGGGCAGCAGCCTCCCACTAGTTACCCACCCCAAACTGGATCCTACAGCCAAGCTCCAAGTCAATA
TAGCCAACAGAGCAGCAGCTACGGGCAGCAGAGTTCATTCCGACAGGACCACCCCAGTAGCATGGGTGTTTATGGGCAGGAGTCTGGAGG
ATTTTCCGGACCAGGAGAGAACCGGAGCATGAGTGGCCCTGATAACCGGGGCAGGGGAAGAGGGGGATTTGATCGTGGAGGCATGAGCAG
AGGTGGGCGGGGAGGAGGACGCGGTGGAATGGGCAGCGCTGGAGAGCGAGGTGGCTTCAATAAGCCTGGTGGCACCGCCCCTGGGGCTGA
GGGGCCGGCGCCTGGGGACTCCCAGGCTGTGCGCCCCTACAAGCAGGAGCCCAGCAGCCCCCCGCTGGCGCCTGGCCTGCCCGCCTTCCT
AGCGGCCCCGGGCACCACGTCCTGCCCCGAGTGCGGCAAAACGTCCCTGAAACCAGCTCACCTGCTGCGCCACCGGCAGAGCCACTCGGG
CGAGAAGCCGCACGCCTGCCCTGAGTGCGGGAAGGCCTTTCGGCGCAAGGAGCACCTGCGGCGCCACCGCGACACGCACCCCGGCAGCCC
CGGCAGCCCCGGGCCCGCGCTGCGCCCTCTGCCCGCCCGTGAGAAGCCCCACGCGTGCTGCGAGTGTGGCAAGACCTTCTACTGGCGCGA
GCACCTGGTGCGCCACCGCAAGACGCACTCGGGAGCGCGGCCCTTTGCCTGCTGGGAGTGTGGCAAGGGCTTCGGGCGCCGCGAGCACGT
GCTGCGCCACCAGCGCATCCACGGCCGGGCAGCGGCCAGCGCGCAGGGGGCGGTAGCTCCGGGCCCGGATGGTGGAGGCCCCTTCCCGCC
CTGGCCCTTGGGTTAGCCGCCTCCCGGCCAGCGCCATCTCCCGCCCTTGGTGCTGCCCCCGGGCGGTACCTGCTCTCTCCCAGCGCCACT
TGGCCTCTTCCTCTCCTCCTTCCCTCCCATCGTCCTCCTCCACCTGCGCCTCCCTTGTCTGAACTTCCCAACGCCTTCCTATTCCTTTCC
AACTCCTTTTCCCCCAAATTTCACTTTCCTTCTCAGGTCTCACCTCAGCCCCCCCCTTCTCCCTGATTTCTCGGCCTCTCTCTCTGTGTG
AAGGGGCCTCTCCCTAATGTCTCCTCCTTCCCCCCTCTTCTCTCTCCTGCGGCCCAGCCTCCCTCTCCCTCCTCCATTCCTCTCTCCCTG
CCCTTTTCCTGCCTGAAGAGCAGAGGTGAGGACCTGGGACCCCTGAGGGGCAGGCCAGGAGGAGCTCGGGCGCAGGCCAGGCCCCCTTGG
TGAAGCAGAGGCTGAAGGAAAGGGGTCTGGGTCTTGTCCCTAGGAATTCTCCTCCCTCAGGAGATTGGGGGTTGGGGGAGGCAGCGGGTG
ATGGCTCTGAAGCTGAACCCAGGGCCTGGCTGTGGTCTTCTTGGTCTTGCTGCCCCCTGTGACCCAAAGGCATGGGATGGACAGAGATGC
CTGCCCCCGTGAAGCTGGTTGGGGAGGGCAGTTCACCAGCATCCATAGAGTAATAAAGTCACTGTGTGTAGACCCGGA

>27861_27861_9_EWSR1-ZNF444_EWSR1_chr22_29687588_ENST00000397938_ZNF444_chr19_56670992_ENST00000592949_length(amino acids)=528AA_BP=401
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQSSFRQD
HPSSMGVYGQESGGFSGPGENRSMSGPDNRGRGRGGFDRGGMSRGGRGGGRGGMGSAGERGGFNKPGGTAPGAEGPAPGDSQAVRPYKQE
PSSPPLAPGLPAFLAAPGTTSCPECGKTSLKPAHLLRHRQSHSGEKPHACPECGKAFRRKEHLRRHRDTHPGSPGSPGPALRPLPAREKP
HACCECGKTFYWREHLVRHRKTHSGARPFACWECGKGFGRREHVLRHQRIHGRAAASAQGAVAPGPDGGGPFPPWPLG

--------------------------------------------------------------
>27861_27861_10_EWSR1-ZNF444_EWSR1_chr22_29687588_ENST00000406548_ZNF444_chr19_56670992_ENST00000592949_length(transcript)=2340nt_BP=1073nt
GCGGCGCCTAGAGGGAAAGCGAGAGGGAGACGGACGTTGAGAGAACGAGGAGGAAGGAGAGAAAATGGCGTCCACGGATTACAGTACCTA
TAGCCAAGCTGCAGCGCAGCAGGGCTACAGTGCTTACACCGCCCAGCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACA
AAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACTTC
TTATGGACAGCCTCCCACTGGTTATACTACTCCAACTGCCCCCCAGGCATACAGCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGA
TACCACCACTGCTACAGTCACCACCACCCAGGCCTCCTATGCAGCTCAGTCTGCATATGGCACTCAGCCTGCTTATCCAGCCTATGGGCA
GCAGCCAGCAGCCACTGCACCTACAAGACCGCAGGATGGAAACAAGCCCACTGAGACTAGTCAACCTCAATCTAGCACAGGGGGTTACAA
CCAGCCCAGCCTAGGATATGGACAGAGTAACTACAGTTATCCCCAGGTACCTGGGAGCTACCCCATGCAGCCAGTCACTGCACCTCCATC
CTACCCTCCTACCAGCTATTCCTCTACACAGCCGACTAGTTATGATCAGAGCAGTTACTCTCAGCAGAACACCTATGGGCAACCGAGCAG
CTATGGACAGCAGAGTAGCTATGGTCAACAAAGCAGCTATGGGCAGCAGCCTCCCACTAGTTACCCACCCCAAACTGGATCCTACAGCCA
AGCTCCAAGTCAATATAGCCAACAGAGCAGCAGCTACGGGCAGCAGAGTTCATTCCGACAGGACCACCCCAGTAGCATGGGTGTTTATGG
GCAGGAGTCTGGAGGATTTTCCGGACCAGGAGAGAACCGGAGCATGAGTGGCCCTGATAACCGGGGCAGGGGAAGAGGGGGATTTGATCG
TGGAGGCATGAGCAGAGGTGGGCGGGGAGGAGGACGCGGTGGAATGGGCGCTGGAGAGCGAGGTGGCTTCAATAAGCCTGGTGGCACCGC
CCCTGGGGCTGAGGGGCCGGCGCCTGGGGACTCCCAGGCTGTGCGCCCCTACAAGCAGGAGCCCAGCAGCCCCCCGCTGGCGCCTGGCCT
GCCCGCCTTCCTAGCGGCCCCGGGCACCACGTCCTGCCCCGAGTGCGGCAAAACGTCCCTGAAACCAGCTCACCTGCTGCGCCACCGGCA
GAGCCACTCGGGCGAGAAGCCGCACGCCTGCCCTGAGTGCGGGAAGGCCTTTCGGCGCAAGGAGCACCTGCGGCGCCACCGCGACACGCA
CCCCGGCAGCCCCGGCAGCCCCGGGCCCGCGCTGCGCCCTCTGCCCGCCCGTGAGAAGCCCCACGCGTGCTGCGAGTGTGGCAAGACCTT
CTACTGGCGCGAGCACCTGGTGCGCCACCGCAAGACGCACTCGGGAGCGCGGCCCTTTGCCTGCTGGGAGTGTGGCAAGGGCTTCGGGCG
CCGCGAGCACGTGCTGCGCCACCAGCGCATCCACGGCCGGGCAGCGGCCAGCGCGCAGGGGGCGGTAGCTCCGGGCCCGGATGGTGGAGG
CCCCTTCCCGCCCTGGCCCTTGGGTTAGCCGCCTCCCGGCCAGCGCCATCTCCCGCCCTTGGTGCTGCCCCCGGGCGGTACCTGCTCTCT
CCCAGCGCCACTTGGCCTCTTCCTCTCCTCCTTCCCTCCCATCGTCCTCCTCCACCTGCGCCTCCCTTGTCTGAACTTCCCAACGCCTTC
CTATTCCTTTCCAACTCCTTTTCCCCCAAATTTCACTTTCCTTCTCAGGTCTCACCTCAGCCCCCCCCTTCTCCCTGATTTCTCGGCCTC
TCTCTCTGTGTGAAGGGGCCTCTCCCTAATGTCTCCTCCTTCCCCCCTCTTCTCTCTCCTGCGGCCCAGCCTCCCTCTCCCTCCTCCATT
CCTCTCTCCCTGCCCTTTTCCTGCCTGAAGAGCAGAGGTGAGGACCTGGGACCCCTGAGGGGCAGGCCAGGAGGAGCTCGGGCGCAGGCC
AGGCCCCCTTGGTGAAGCAGAGGCTGAAGGAAAGGGGTCTGGGTCTTGTCCCTAGGAATTCTCCTCCCTCAGGAGATTGGGGGTTGGGGG
AGGCAGCGGGTGATGGCTCTGAAGCTGAACCCAGGGCCTGGCTGTGGTCTTCTTGGTCTTGCTGCCCCCTGTGACCCAAAGGCATGGGAT
GGACAGAGATGCCTGCCCCCGTGAAGCTGGTTGGGGAGGGCAGTTCACCAGCATCCATAGAGTAATAAAGTCACTGTGTGTAGACCCGGA


>27861_27861_10_EWSR1-ZNF444_EWSR1_chr22_29687588_ENST00000406548_ZNF444_chr19_56670992_ENST00000592949_length(amino acids)=527AA_BP=400
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQSSFRQD
HPSSMGVYGQESGGFSGPGENRSMSGPDNRGRGRGGFDRGGMSRGGRGGGRGGMGAGERGGFNKPGGTAPGAEGPAPGDSQAVRPYKQEP
SSPPLAPGLPAFLAAPGTTSCPECGKTSLKPAHLLRHRQSHSGEKPHACPECGKAFRRKEHLRRHRDTHPGSPGSPGPALRPLPAREKPH
ACCECGKTFYWREHLVRHRKTHSGARPFACWECGKGFGRREHVLRHQRIHGRAAASAQGAVAPGPDGGGPFPPWPLG

--------------------------------------------------------------
>27861_27861_11_EWSR1-ZNF444_EWSR1_chr22_29687588_ENST00000414183_ZNF444_chr19_56670992_ENST00000592949_length(transcript)=2315nt_BP=1048nt
AACGAGGAGGAAGGAGAGAAAATGGCGTCCACGGATTACAGTACCTATAGCCAAGCTGCAGCGCAGCAGGGCTACAGTGCTTACACCGCC
CAGCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACC
CAGGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCCCACTGTAGAAGGGACCAGTACAGGTTAT
ACTACTCCAACTGCCCCCCAGGCATACAGCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGATACCACCACTGCTACAGTCACCACC
ACCCAGGCCTCCTATGCAGCTCAGTCTGCATATGGCACTCAGCCTGCTTATCCAGCCTATGGGCAGCAGCCAGCAGCCACTGCACCTACA
AGACCGCAGGATGGAAACAAGCCCACTGAGACTAGTCAACCTCAATCTAGCACAGGGGGTTACAACCAGCCCAGCCTAGGATATGGACAG
AGTAACTACAGTTATCCCCAGGTACCTGGGAGCTACCCCATGCAGCCAGTCACTGCACCTCCATCCTACCCTCCTACCAGCTATTCCTCT
ACACAGCCGACTAGTTATGATCAGAGCAGTTACTCTCAGCAGAACACCTATGGGCAACCGAGCAGCTATGGACAGCAGAGTAGCTATGGT
CAACAAAGCAGCTATGGGCAGCAGCCTCCCACTAGTTACCCACCCCAAACTGGATCCTACAGCCAAGCTCCAAGTCAATATAGCCAACAG
AGCAGCAGCTACGGGCAGCAGAGTTCATTCCGACAGGACCACCCCAGTAGCATGGGTGTTTATGGGCAGGAGTCTGGAGGATTTTCCGGA
CCAGGAGAGAACCGGAGCATGAGTGGCCCTGATAACCGGGGCAGGGGAAGAGGGGGATTTGATCGTGGAGGCATGAGCAGAGGTGGGCGG
GGAGGAGGACGCGGTGGAATGGGCGCTGGAGAGCGAGGTGGCTTCAATAAGCCTGGTGGCACCGCCCCTGGGGCTGAGGGGCCGGCGCCT
GGGGACTCCCAGGCTGTGCGCCCCTACAAGCAGGAGCCCAGCAGCCCCCCGCTGGCGCCTGGCCTGCCCGCCTTCCTAGCGGCCCCGGGC
ACCACGTCCTGCCCCGAGTGCGGCAAAACGTCCCTGAAACCAGCTCACCTGCTGCGCCACCGGCAGAGCCACTCGGGCGAGAAGCCGCAC
GCCTGCCCTGAGTGCGGGAAGGCCTTTCGGCGCAAGGAGCACCTGCGGCGCCACCGCGACACGCACCCCGGCAGCCCCGGCAGCCCCGGG
CCCGCGCTGCGCCCTCTGCCCGCCCGTGAGAAGCCCCACGCGTGCTGCGAGTGTGGCAAGACCTTCTACTGGCGCGAGCACCTGGTGCGC
CACCGCAAGACGCACTCGGGAGCGCGGCCCTTTGCCTGCTGGGAGTGTGGCAAGGGCTTCGGGCGCCGCGAGCACGTGCTGCGCCACCAG
CGCATCCACGGCCGGGCAGCGGCCAGCGCGCAGGGGGCGGTAGCTCCGGGCCCGGATGGTGGAGGCCCCTTCCCGCCCTGGCCCTTGGGT
TAGCCGCCTCCCGGCCAGCGCCATCTCCCGCCCTTGGTGCTGCCCCCGGGCGGTACCTGCTCTCTCCCAGCGCCACTTGGCCTCTTCCTC
TCCTCCTTCCCTCCCATCGTCCTCCTCCACCTGCGCCTCCCTTGTCTGAACTTCCCAACGCCTTCCTATTCCTTTCCAACTCCTTTTCCC
CCAAATTTCACTTTCCTTCTCAGGTCTCACCTCAGCCCCCCCCTTCTCCCTGATTTCTCGGCCTCTCTCTCTGTGTGAAGGGGCCTCTCC
CTAATGTCTCCTCCTTCCCCCCTCTTCTCTCTCCTGCGGCCCAGCCTCCCTCTCCCTCCTCCATTCCTCTCTCCCTGCCCTTTTCCTGCC
TGAAGAGCAGAGGTGAGGACCTGGGACCCCTGAGGGGCAGGCCAGGAGGAGCTCGGGCGCAGGCCAGGCCCCCTTGGTGAAGCAGAGGCT
GAAGGAAAGGGGTCTGGGTCTTGTCCCTAGGAATTCTCCTCCCTCAGGAGATTGGGGGTTGGGGGAGGCAGCGGGTGATGGCTCTGAAGC
TGAACCCAGGGCCTGGCTGTGGTCTTCTTGGTCTTGCTGCCCCCTGTGACCCAAAGGCATGGGATGGACAGAGATGCCTGCCCCCGTGAA
GCTGGTTGGGGAGGGCAGTTCACCAGCATCCATAGAGTAATAAAGTCACTGTGTGTAGACCCGGA

>27861_27861_11_EWSR1-ZNF444_EWSR1_chr22_29687588_ENST00000414183_ZNF444_chr19_56670992_ENST00000592949_length(amino acids)=533AA_BP=406
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTVEGTSTGYTTPTAPQ
AYSQPVQGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQ
VPGSYPMQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQ
SSFRQDHPSSMGVYGQESGGFSGPGENRSMSGPDNRGRGRGGFDRGGMSRGGRGGGRGGMGAGERGGFNKPGGTAPGAEGPAPGDSQAVR
PYKQEPSSPPLAPGLPAFLAAPGTTSCPECGKTSLKPAHLLRHRQSHSGEKPHACPECGKAFRRKEHLRRHRDTHPGSPGSPGPALRPLP
AREKPHACCECGKTFYWREHLVRHRKTHSGARPFACWECGKGFGRREHVLRHQRIHGRAAASAQGAVAPGPDGGGPFPPWPLG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EWSR1-ZNF444


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EWSR1-ZNF444


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EWSR1-ZNF444


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEWSR1C0553580Ewings sarcoma3CTD_human;ORPHANET
HgeneEWSR1C0002736Amyotrophic Lateral Sclerosis1GENOMICS_ENGLAND
HgeneEWSR1C0033578Prostatic Neoplasms1CTD_human
HgeneEWSR1C0206651Clear Cell Sarcoma of Soft Tissue1ORPHANET
HgeneEWSR1C0206663Neuroectodermal Tumor, Primitive1CTD_human
HgeneEWSR1C0279980Extra-osseous Ewing's sarcoma1ORPHANET
HgeneEWSR1C0334584Spongioblastoma1CTD_human
HgeneEWSR1C0334596Medulloepithelioma1CTD_human
HgeneEWSR1C0376358Malignant neoplasm of prostate1CTD_human
HgeneEWSR1C0700367Ependymoblastoma1CTD_human
HgeneEWSR1C0751675Cerebral Primitive Neuroectodermal Tumor1CTD_human
HgeneEWSR1C1275278Extraskeletal Myxoid Chondrosarcoma1ORPHANET