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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EXT2-PRMT9 (FusionGDB2 ID:HG2132TG90826)

Fusion Gene Summary for EXT2-PRMT9

check button Fusion gene summary
Fusion gene informationFusion gene name: EXT2-PRMT9
Fusion gene ID: hg2132tg90826
HgeneTgene
Gene symbol

EXT2

PRMT9

Gene ID

2132

90826

Gene nameexostosin glycosyltransferase 2protein arginine methyltransferase 9
SynonymsSOTV|SSMSPRMT10
Cytomap('EXT2','EXT2')('PRMT10','PRMT9')

11p11.2

4q31.23

Type of geneprotein-codingprotein-coding
Descriptionexostosin-2N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferaseglucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferasemultiple exostoses protein 2multiple exostosis 2putativprotein arginine N-methyltransferase 9protein arginine N-methyltransferase 10protein arginine methyltransferase 10 (putative)putative protein arginine N-methyltransferase 10putative protein arginine N-methyltransferase 9
Modification date2020031320200313
UniProtAcc

Q93063

.
Ensembl transtripts involved in fusion geneENST00000343631, ENST00000358681, 
ENST00000395673, ENST00000533608, 
ENST00000529186, 
Fusion gene scores* DoF score8 X 6 X 8=3842 X 2 X 2=8
# samples 92
** MAII scorelog2(9/384*10)=-2.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: EXT2 [Title/Abstract] AND PRMT9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEXT2(44151688)-PRMT10(148601622), # samples:2
EXT2(44151688)-PRMT9(148601622), # samples:1
Anticipated loss of major functional domain due to fusion event.EXT2-PRMT10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EXT2-PRMT10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EXT2-PRMT10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EXT2-PRMT10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEXT2

GO:0006024

glycosaminoglycan biosynthetic process

12907669

HgeneEXT2

GO:0033692

cellular polysaccharide biosynthetic process

12907669


check buttonFusion gene breakpoints across EXT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PRMT9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-8354-01AEXT2chr11

44151688

-PRMT10chr4

148601622

-
ChimerDB4LUSCTCGA-85-8354EXT2chr11

44151688

+PRMT10chr4

148601622

-
ChimerDB4LUSCTCGA-85-8354-01AEXT2chr11

44151688

+PRMT9chr4

148601622

-


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Fusion Gene ORF analysis for EXT2-PRMT9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000343631ENST00000541232EXT2chr11

44151688

+PRMT10chr4

148601622

-
5CDS-intronENST00000358681ENST00000541232EXT2chr11

44151688

+PRMT10chr4

148601622

-
5CDS-intronENST00000395673ENST00000541232EXT2chr11

44151688

+PRMT10chr4

148601622

-
5CDS-intronENST00000533608ENST00000541232EXT2chr11

44151688

+PRMT10chr4

148601622

-
In-frameENST00000343631ENST00000322396EXT2chr11

44151688

+PRMT10chr4

148601622

-
In-frameENST00000358681ENST00000322396EXT2chr11

44151688

+PRMT10chr4

148601622

-
In-frameENST00000395673ENST00000322396EXT2chr11

44151688

+PRMT10chr4

148601622

-
In-frameENST00000533608ENST00000322396EXT2chr11

44151688

+PRMT10chr4

148601622

-
intron-3CDSENST00000529186ENST00000322396EXT2chr11

44151688

+PRMT10chr4

148601622

-
intron-intronENST00000529186ENST00000541232EXT2chr11

44151688

+PRMT10chr4

148601622

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000533608EXT2chr1144151688+ENST00000322396PRMT10chr4148601622-46031507438551283
ENST00000358681EXT2chr1144151688+ENST00000322396PRMT10chr4148601622-443513393436871217
ENST00000395673EXT2chr1144151688+ENST00000322396PRMT10chr4148601622-442413283836761212
ENST00000343631EXT2chr1144151688+ENST00000322396PRMT10chr4148601622-439813021236501212

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000533608ENST00000322396EXT2chr1144151688+PRMT10chr4148601622-0.0003553320.99964464
ENST00000358681ENST00000322396EXT2chr1144151688+PRMT10chr4148601622-0.0002683860.9997316
ENST00000395673ENST00000322396EXT2chr1144151688+PRMT10chr4148601622-0.0002257620.9997743
ENST00000343631ENST00000322396EXT2chr1144151688+PRMT10chr4148601622-0.0002165440.99978346

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Fusion Genomic Features for EXT2-PRMT9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for EXT2-PRMT9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:44151688/:148601622)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EXT2

Q93063

.
FUNCTION: Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:22660413}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEXT2chr11:44151688chr4:148601622ENST00000343631+7141_25391719.0Topological domainCytoplasmic
HgeneEXT2chr11:44151688chr4:148601622ENST00000358681+7151_25391729.0Topological domainCytoplasmic
HgeneEXT2chr11:44151688chr4:148601622ENST00000395673+7141_25424752.0Topological domainCytoplasmic
HgeneEXT2chr11:44151688chr4:148601622ENST00000533608+7141_25391719.0Topological domainCytoplasmic
HgeneEXT2chr11:44151688chr4:148601622ENST00000343631+71426_46391719.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneEXT2chr11:44151688chr4:148601622ENST00000358681+71526_46391729.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneEXT2chr11:44151688chr4:148601622ENST00000395673+71426_46424752.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneEXT2chr11:44151688chr4:148601622ENST00000533608+71426_46391719.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgenePRMT10chr11:44151688chr4:148601622ENST00000322396012137_46663846.0DomainSAM-dependent MTase PRMT-type 1
TgenePRMT10chr11:44151688chr4:148601622ENST00000322396012530_84563846.0DomainSAM-dependent MTase PRMT-type 2
TgenePRMT10chr11:44151688chr4:148601622ENST00000322396012101_13463846.0RepeatNote=TPR 3
TgenePRMT10chr11:44151688chr4:148601622ENST0000032239601267_10063846.0RepeatNote=TPR 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEXT2chr11:44151688chr4:148601622ENST00000343631+714517_522391719.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr4:148601622ENST00000343631+714538_540391719.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr4:148601622ENST00000343631+714624_628391719.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr4:148601622ENST00000343631+714662_673391719.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr4:148601622ENST00000358681+715517_522391729.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr4:148601622ENST00000358681+715538_540391729.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr4:148601622ENST00000358681+715624_628391729.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr4:148601622ENST00000358681+715662_673391729.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr4:148601622ENST00000395673+714517_522424752.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr4:148601622ENST00000395673+714538_540424752.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr4:148601622ENST00000395673+714624_628424752.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr4:148601622ENST00000395673+714662_673424752.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr4:148601622ENST00000533608+714517_522391719.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr4:148601622ENST00000533608+714538_540391719.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr4:148601622ENST00000533608+714624_628391719.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr4:148601622ENST00000533608+714662_673391719.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr4:148601622ENST00000343631+71447_718391719.0Topological domainLumenal
HgeneEXT2chr11:44151688chr4:148601622ENST00000358681+71547_718391729.0Topological domainLumenal
HgeneEXT2chr11:44151688chr4:148601622ENST00000395673+71447_718424752.0Topological domainLumenal
HgeneEXT2chr11:44151688chr4:148601622ENST00000533608+71447_718391719.0Topological domainLumenal
TgenePRMT10chr11:44151688chr4:148601622ENST0000032239601225_5863846.0RepeatNote=TPR 1


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Fusion Gene Sequence for EXT2-PRMT9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28024_28024_1_EXT2-PRMT10_EXT2_chr11_44151688_ENST00000343631_PRMT10_chr4_148601622_ENST00000322396_length(transcript)=4398nt_BP=1302nt
AGCCACAGGGATCTGATTCCTCCCAGGGGGATGTCCTGCGCCTCAGGGTCCGGTGGTGGCCTGCGGCATCCCTTGCGGTGCCAGAAGCCG
TGGGACGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGTCAAGTATAATATCCGGGGTCCTGCCCTCATCCCAAGA
ATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCTGGGCCTCATTGCCACTGGCATGTTTCAGTTTTGGCCC
CATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGATGTGCCGGTTGTTAGGCTGCCAGCCGACAGTCCCATC
CCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCGCTGTGGCTTCAACCCAAAGAACAAAATCAAGGTGTAT
ATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACACCATCTCCCGGGAGTATAATGAACTGCTCATGGCCATC
TCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCCCTCCATCGATGTGCTTAACCAGAACACACTGCGCATC
AAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAATCACCTGTTGTTCAACATGTTGCCTGGAGGTCCCCCA
GATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGGCGGCTTTTCTACGTGGACTTACCGGCAAGGCTACGAT
GTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAAAGGACCAGGTCCACGGCAATACTTCCTCCTGTCATCT
CAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAAACATGGAGAGTCAGTGTTAGTACTCGATAAATGCACC
AACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGTCTTCGATTACCCACAGGTGCTACAGGAGGCTACTTTC
TGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTTACAAGCTGGCTGTGTCCCGGTTGTCATTGCAGACTCC
TATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGTACCAGAAGAAAAGATGTCAGATGTGTACAGTATTTTG
CAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGGAAACTTTTCAGTACACACTTTTCAGATGGGCTGAAGAGCTTGATGCT
CTCAGTCGGATACAAGACTTACTTGGTTGCTATGAGCAGGCCTTGGAACTGTTTCCTGATGATGAAGTGATTTGCAATAGTATGGGGGAG
CATCTCTTCAGAATGGGCTTTAGGGATGAAGCAGCTGGGTATTTTCATAAAGCAGTGAAGCTAAACCCTGATTTCAGTGATGCAAAGGAG
AATTTTTATCGTGTTGCAAACTGGTTGGTGGAACGCTGGCACTTTATCATGCTTAATGACACCAAGAGGAATACAATTTATAATGCAGCA
ATCCAAAAGGCAGTTTGTTTGGGGTCCAAAAGTGTTTTGGACATTGGAGCAGGAACTGGAATACTAAGCATGTTTGCTAAAAAAGCTGGA
GCACATTCCGTGTATGCCTGTGAGTTATCCAAGACCATGTATGAACTTGCCTGTGATGTCGTGGCAGCAAACAAGATGGAAGCAGGGATC
AAACTCTTACATACGAAGTCACTTGACATAGAGATTCCAAAACATATTCCCGAAAGAGTGTCCCTAGTTGTAACAGAAACTGTCGATGCA
GGTTTATTTGGAGAAGGAATTGTGGAGAGTTTGATTCATGCATGGGAGCATTTACTTTTACAGCCAAAGACCAAAGGTGAAAGTGCTAAT
TGTGAAAAGTATGGGAAAGTTATACCAGCAAGTGCTGTTATATTTGGGATGGCAGTAGAATGTGCAGAGATAAGAAGACATCATAGAGTG
GGTATTAAGGACATTGCTGGTATCCATTTGCCAACAAATGTGAAATTTCAGAGTCCGGCTTATTCTTCTGTAGATACTGAAGAAACAATT
GAACCTTATACAACTGAAAAGATGAGTCGAGTTCCTGGAGGATATTTGGCTTTGACAGAGTGCTTTGAAATTATGACAGTAGATTTCAAC
AACCTTCAGGAATTAAAAAGTCTTGCAACTAAAAAGCCTGATAAGATTGGTATTCCTGTTATTAAAGAAGGCATACTAGATGCTATTATG
GTTTGGTTTGTGCTCCAGCTTGATGATGAACATAGTTTATCCACAAGTCCTAGTGAGGAAACATGTTGGGAACAGGCTGTCTACCCCGTA
CAGGACCTTGCAGACTACTGGATAAAGCCTGGAGACCATGTGATGATGGAAGTATCTTGTCAAGACTGTTACTTAAGAATCCAGAGTATT
AGTGTCTTGGGTTTGGAATGTGAAATGGATGTTGCAAAAAGTTTTACCCAGAATAAAGACTTGTTATCGTTAGGAAATGAGGCTGAACTT
TGTAGTGCCCTCGCTAACCTTCAGACCAGTAAACCAGATGCTGTAGAGCAGACATGTATATTGGAATCTACAGAAATTGCTTTGCTTAAC
AACATCCCATATCATGAAGGCTTTAAAATGGCAATGAGCAAAGTTTTGTCTTCACTGACTCCAGAGAAACTGTATCAGACCATGGATACT
CACTGTCAGAATGAGATGAGCTCTGGAACTGGACAGAGTAATACTGTACAGAACATCCTTGAACCTTTCTACGTGTTAGATGTGTCCGAA
GGCTTCTCTGTTCTGCCTGTTATTGCTGGCACACTTGGGCAGGTTAAACCATACAGTTCTGTGGAGAAAGACCAGCATCGTATTGCTCTG
GACCTCATATCTGAAGCCAATCACTTTCCTAAAGAAACACTTGAGTTTTGGCTGAGACATGTGGAGGATGAATCTGCTATGTTACAAAGG
CCAAAATCAGACAAGTTATGGAGCATAATTATATTGGATGTCATTGAGCCATCTGGGCTCATTCAGCAGGAAATAATGGAAAAAGCTGCA
ATATCCAGGTGTTTACTACAATCTGGAGGCAAGATCTTTCCTCAGTATGTGCTGATGTTTGGGTTGCTTGTGGAATCACAGACACTCCTA
GAGGAGAATGCTGTTCAAGGAACAGAACGTACTCTTGGATTAAATATAGCACCTTTTATTAACCAGTTTCAGGTACCTATACGTGTATTT
TTGGACCTATCCTCATTGCCCTGTATACCTTTAAGCAAGCCAGTGGAACTCTTAAGACTAGATTTAATGACTCCGTATTTGAACACCTCT
AACAGAGAAGTAAAGGTATACGTTTGTAAATCTGGAAGACTGACTGCTATTCCATTTTGGTATCATATGTACCTTGATGAAGAGATTAGG
TTGGATACTTCAAGTGAAGCCTCCCACTGGAAACAAGCTGCAGTTGTTTTAGATAATCCCATCCAGGTTGAAATGGGAGAGGAACTTGTA
CTCAGCATTCAGCATCACAAAAGCAATGTCAGCATCACAGTAAAGCAATGAAGAGCAGTTTTCCAATGAAAACTGTGTAAATAGAGCATC
AACAAGTACAAAATTCTTGTCTTAATTAGTGGGGGTATATAAAAATTCCTTGTAATGGTCAAATATTTTTTAAAATTGACATTAATAAAG
CATATTTTAAAAGATTCTAAATAAAAGGGTAGCATTATTATAGAAATACTGCTGCAGATTTGCTTTCTGGAAAAGGATACATCACTAGTT
TTTTAAATTAGGAAACTTCTTTTGCTCGATTTTACAGAATAGGGATTTTAAAAGTCTTATCGTTATTGACATGTGTAAGTAAAGCAAAAC
TTTACTTTTGTAGGCATCTTGGCCTTTTTTCTTAAATCCAAACTTGTAATTGGGAAACACTGAAAGGCTTCCACTGAAGACTGAGGGTTA
TGGTTACCTGTAAATTCCAATCTTGCTTCCTTTAAATACTCAGTGTACATCTGAAACATCTCAGGTTTTGTTTTGAGAATGCAAGCTTGA
AAAAGAATTTAAGCTATAAGCTAAATGTAATTAAAACAGTAAAGGAGTTAGGGAATACATCTTCAGGAGGCAGCATTTTTCTTGGTCTAC
TTTGGCAAAAGAACATTTAAAAGCTGGTAACAAAACAAAGTTAAATTGAAGGAAGACTTAATCCTATACTATTTTTCAAAGTTTTGATTT

>28024_28024_1_EXT2-PRMT10_EXT2_chr11_44151688_ENST00000343631_PRMT10_chr4_148601622_ENST00000322396_length(amino acids)=1212AA_BP=430
MIPPRGMSCASGSGGGLRHPLRCQKPWDEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIE
SSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSD
YYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIP
VYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVL
RGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQETFQYTLFRWAEELDALSRI
QDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFSDAKENFYRVANWLVERWHFIMLNDTKRNTIYNAAIQKA
VCLGSKSVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMEAGIKLLHTKSLDIEIPKHIPERVSLVVTETVDAGLFG
EGIVESLIHAWEHLLLQPKTKGESANCEKYGKVIPASAVIFGMAVECAEIRRHHRVGIKDIAGIHLPTNVKFQSPAYSSVDTEETIEPYT
TEKMSRVPGGYLALTECFEIMTVDFNNLQELKSLATKKPDKIGIPVIKEGILDAIMVWFVLQLDDEHSLSTSPSEETCWEQAVYPVQDLA
DYWIKPGDHVMMEVSCQDCYLRIQSISVLGLECEMDVAKSFTQNKDLLSLGNEAELCSALANLQTSKPDAVEQTCILESTEIALLNNIPY
HEGFKMAMSKVLSSLTPEKLYQTMDTHCQNEMSSGTGQSNTVQNILEPFYVLDVSEGFSVLPVIAGTLGQVKPYSSVEKDQHRIALDLIS
EANHFPKETLEFWLRHVEDESAMLQRPKSDKLWSIIILDVIEPSGLIQQEIMEKAAISRCLLQSGGKIFPQYVLMFGLLVESQTLLEENA
VQGTERTLGLNIAPFINQFQVPIRVFLDLSSLPCIPLSKPVELLRLDLMTPYLNTSNREVKVYVCKSGRLTAIPFWYHMYLDEEIRLDTS

--------------------------------------------------------------
>28024_28024_2_EXT2-PRMT10_EXT2_chr11_44151688_ENST00000358681_PRMT10_chr4_148601622_ENST00000322396_length(transcript)=4435nt_BP=1339nt
CTCGCCAGCCCAGACTCGGCCCTGGCAGTGGCGGCTGGCGATTCGGACCGATCCGACCTGGGCGGAGGTGGCCCGCGCCCCGCGGCATGA
GCCGGTGACCAAGCTCGGGGCCGAGCGGGAGGCAGCCGTGGCCGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGT
CAAGTATAATATCCGGGGTCCTGCCCTCATCCCAAGAATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCT
GGGCCTCATTGCCACTGGCATGTTTCAGTTTTGGCCCCATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGA
TGTGCCGGTTGTTAGGCTGCCAGCCGACAGTCCCATCCCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCG
CTGTGGCTTCAACCCAAAGAACAAAATCAAGGTGTATATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACAC
CATCTCCCGGGAGTATAATGAACTGCTCATGGCCATCTCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCC
CTCCATCGATGTGCTTAACCAGAACACACTGCGCATCAAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAA
TCACCTGTTGTTCAACATGTTGCCTGGAGGTCCCCCAGATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGG
CGGCTTTTCTACGTGGACTTACCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAA
AGGACCAGGTCCACGGCAATACTTCCTCCTGTCATCTCAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAA
ACATGGAGAGTCAGTGTTAGTACTCGATAAATGCACCAACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGT
CTTCGATTACCCACAGGTGCTACAGGAGGCTACTTTCTGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTT
ACAAGCTGGCTGTGTCCCGGTTGTCATTGCAGACTCCTATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGT
ACCAGAAGAAAAGATGTCAGATGTGTACAGTATTTTGCAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGGAAACTTTTCA
GTACACACTTTTCAGATGGGCTGAAGAGCTTGATGCTCTCAGTCGGATACAAGACTTACTTGGTTGCTATGAGCAGGCCTTGGAACTGTT
TCCTGATGATGAAGTGATTTGCAATAGTATGGGGGAGCATCTCTTCAGAATGGGCTTTAGGGATGAAGCAGCTGGGTATTTTCATAAAGC
AGTGAAGCTAAACCCTGATTTCAGTGATGCAAAGGAGAATTTTTATCGTGTTGCAAACTGGTTGGTGGAACGCTGGCACTTTATCATGCT
TAATGACACCAAGAGGAATACAATTTATAATGCAGCAATCCAAAAGGCAGTTTGTTTGGGGTCCAAAAGTGTTTTGGACATTGGAGCAGG
AACTGGAATACTAAGCATGTTTGCTAAAAAAGCTGGAGCACATTCCGTGTATGCCTGTGAGTTATCCAAGACCATGTATGAACTTGCCTG
TGATGTCGTGGCAGCAAACAAGATGGAAGCAGGGATCAAACTCTTACATACGAAGTCACTTGACATAGAGATTCCAAAACATATTCCCGA
AAGAGTGTCCCTAGTTGTAACAGAAACTGTCGATGCAGGTTTATTTGGAGAAGGAATTGTGGAGAGTTTGATTCATGCATGGGAGCATTT
ACTTTTACAGCCAAAGACCAAAGGTGAAAGTGCTAATTGTGAAAAGTATGGGAAAGTTATACCAGCAAGTGCTGTTATATTTGGGATGGC
AGTAGAATGTGCAGAGATAAGAAGACATCATAGAGTGGGTATTAAGGACATTGCTGGTATCCATTTGCCAACAAATGTGAAATTTCAGAG
TCCGGCTTATTCTTCTGTAGATACTGAAGAAACAATTGAACCTTATACAACTGAAAAGATGAGTCGAGTTCCTGGAGGATATTTGGCTTT
GACAGAGTGCTTTGAAATTATGACAGTAGATTTCAACAACCTTCAGGAATTAAAAAGTCTTGCAACTAAAAAGCCTGATAAGATTGGTAT
TCCTGTTATTAAAGAAGGCATACTAGATGCTATTATGGTTTGGTTTGTGCTCCAGCTTGATGATGAACATAGTTTATCCACAAGTCCTAG
TGAGGAAACATGTTGGGAACAGGCTGTCTACCCCGTACAGGACCTTGCAGACTACTGGATAAAGCCTGGAGACCATGTGATGATGGAAGT
ATCTTGTCAAGACTGTTACTTAAGAATCCAGAGTATTAGTGTCTTGGGTTTGGAATGTGAAATGGATGTTGCAAAAAGTTTTACCCAGAA
TAAAGACTTGTTATCGTTAGGAAATGAGGCTGAACTTTGTAGTGCCCTCGCTAACCTTCAGACCAGTAAACCAGATGCTGTAGAGCAGAC
ATGTATATTGGAATCTACAGAAATTGCTTTGCTTAACAACATCCCATATCATGAAGGCTTTAAAATGGCAATGAGCAAAGTTTTGTCTTC
ACTGACTCCAGAGAAACTGTATCAGACCATGGATACTCACTGTCAGAATGAGATGAGCTCTGGAACTGGACAGAGTAATACTGTACAGAA
CATCCTTGAACCTTTCTACGTGTTAGATGTGTCCGAAGGCTTCTCTGTTCTGCCTGTTATTGCTGGCACACTTGGGCAGGTTAAACCATA
CAGTTCTGTGGAGAAAGACCAGCATCGTATTGCTCTGGACCTCATATCTGAAGCCAATCACTTTCCTAAAGAAACACTTGAGTTTTGGCT
GAGACATGTGGAGGATGAATCTGCTATGTTACAAAGGCCAAAATCAGACAAGTTATGGAGCATAATTATATTGGATGTCATTGAGCCATC
TGGGCTCATTCAGCAGGAAATAATGGAAAAAGCTGCAATATCCAGGTGTTTACTACAATCTGGAGGCAAGATCTTTCCTCAGTATGTGCT
GATGTTTGGGTTGCTTGTGGAATCACAGACACTCCTAGAGGAGAATGCTGTTCAAGGAACAGAACGTACTCTTGGATTAAATATAGCACC
TTTTATTAACCAGTTTCAGGTACCTATACGTGTATTTTTGGACCTATCCTCATTGCCCTGTATACCTTTAAGCAAGCCAGTGGAACTCTT
AAGACTAGATTTAATGACTCCGTATTTGAACACCTCTAACAGAGAAGTAAAGGTATACGTTTGTAAATCTGGAAGACTGACTGCTATTCC
ATTTTGGTATCATATGTACCTTGATGAAGAGATTAGGTTGGATACTTCAAGTGAAGCCTCCCACTGGAAACAAGCTGCAGTTGTTTTAGA
TAATCCCATCCAGGTTGAAATGGGAGAGGAACTTGTACTCAGCATTCAGCATCACAAAAGCAATGTCAGCATCACAGTAAAGCAATGAAG
AGCAGTTTTCCAATGAAAACTGTGTAAATAGAGCATCAACAAGTACAAAATTCTTGTCTTAATTAGTGGGGGTATATAAAAATTCCTTGT
AATGGTCAAATATTTTTTAAAATTGACATTAATAAAGCATATTTTAAAAGATTCTAAATAAAAGGGTAGCATTATTATAGAAATACTGCT
GCAGATTTGCTTTCTGGAAAAGGATACATCACTAGTTTTTTAAATTAGGAAACTTCTTTTGCTCGATTTTACAGAATAGGGATTTTAAAA
GTCTTATCGTTATTGACATGTGTAAGTAAAGCAAAACTTTACTTTTGTAGGCATCTTGGCCTTTTTTCTTAAATCCAAACTTGTAATTGG
GAAACACTGAAAGGCTTCCACTGAAGACTGAGGGTTATGGTTACCTGTAAATTCCAATCTTGCTTCCTTTAAATACTCAGTGTACATCTG
AAACATCTCAGGTTTTGTTTTGAGAATGCAAGCTTGAAAAAGAATTTAAGCTATAAGCTAAATGTAATTAAAACAGTAAAGGAGTTAGGG
AATACATCTTCAGGAGGCAGCATTTTTCTTGGTCTACTTTGGCAAAAGAACATTTAAAAGCTGGTAACAAAACAAAGTTAAATTGAAGGA
AGACTTAATCCTATACTATTTTTCAAAGTTTTGATTTGGATGTACAATAAGTACATTAATTGATCCAATTTTTACAAACTTTTGAAATAA

>28024_28024_2_EXT2-PRMT10_EXT2_chr11_44151688_ENST00000358681_PRMT10_chr4_148601622_ENST00000322396_length(amino acids)=1217AA_BP=435
MAIRTDPTWAEVARAPRHEPVTKLGAEREAAVAEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFW
PHSIESSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMA
ISDSDYYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGY
DVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEAT
FCVVLRGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQETFQYTLFRWAEELD
ALSRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFSDAKENFYRVANWLVERWHFIMLNDTKRNTIYNA
AIQKAVCLGSKSVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMEAGIKLLHTKSLDIEIPKHIPERVSLVVTETVD
AGLFGEGIVESLIHAWEHLLLQPKTKGESANCEKYGKVIPASAVIFGMAVECAEIRRHHRVGIKDIAGIHLPTNVKFQSPAYSSVDTEET
IEPYTTEKMSRVPGGYLALTECFEIMTVDFNNLQELKSLATKKPDKIGIPVIKEGILDAIMVWFVLQLDDEHSLSTSPSEETCWEQAVYP
VQDLADYWIKPGDHVMMEVSCQDCYLRIQSISVLGLECEMDVAKSFTQNKDLLSLGNEAELCSALANLQTSKPDAVEQTCILESTEIALL
NNIPYHEGFKMAMSKVLSSLTPEKLYQTMDTHCQNEMSSGTGQSNTVQNILEPFYVLDVSEGFSVLPVIAGTLGQVKPYSSVEKDQHRIA
LDLISEANHFPKETLEFWLRHVEDESAMLQRPKSDKLWSIIILDVIEPSGLIQQEIMEKAAISRCLLQSGGKIFPQYVLMFGLLVESQTL
LEENAVQGTERTLGLNIAPFINQFQVPIRVFLDLSSLPCIPLSKPVELLRLDLMTPYLNTSNREVKVYVCKSGRLTAIPFWYHMYLDEEI

--------------------------------------------------------------
>28024_28024_3_EXT2-PRMT10_EXT2_chr11_44151688_ENST00000395673_PRMT10_chr4_148601622_ENST00000322396_length(transcript)=4424nt_BP=1328nt
TCCCTTCCTGCTGCCACCTTCCCGCCAGCCACAGGGATCTGATTCCTCCCAGGGGGATGTCCTGCGCCTCAGGGTCCGGTGGTGGCCTGC
GGCATCCCTTGCGGTGCCAGAAGCCGTGGGACGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGTCAAGTATAATA
TCCGGGGTCCTGCCCTCATCCCAAGAATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCTGGGCCTCATTG
CCACTGGCATGTTTCAGTTTTGGCCCCATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGATGTGCCGGTTG
TTAGGCTGCCAGCCGACAGTCCCATCCCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCGCTGTGGCTTCA
ACCCAAAGAACAAAATCAAGGTGTATATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACACCATCTCCCGGG
AGTATAATGAACTGCTCATGGCCATCTCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCCCTCCATCGATG
TGCTTAACCAGAACACACTGCGCATCAAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAATCACCTGTTGT
TCAACATGTTGCCTGGAGGTCCCCCAGATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGGCGGCTTTTCTA
CGTGGACTTACCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAAAGGACCAGGTC
CACGGCAATACTTCCTCCTGTCATCTCAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAAACATGGAGAGT
CAGTGTTAGTACTCGATAAATGCACCAACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGTCTTCGATTACC
CACAGGTGCTACAGGAGGCTACTTTCTGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTTACAAGCTGGCT
GTGTCCCGGTTGTCATTGCAGACTCCTATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGTACCAGAAGAAA
AGATGTCAGATGTGTACAGTATTTTGCAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGGAAACTTTTCAGTACACACTTT
TCAGATGGGCTGAAGAGCTTGATGCTCTCAGTCGGATACAAGACTTACTTGGTTGCTATGAGCAGGCCTTGGAACTGTTTCCTGATGATG
AAGTGATTTGCAATAGTATGGGGGAGCATCTCTTCAGAATGGGCTTTAGGGATGAAGCAGCTGGGTATTTTCATAAAGCAGTGAAGCTAA
ACCCTGATTTCAGTGATGCAAAGGAGAATTTTTATCGTGTTGCAAACTGGTTGGTGGAACGCTGGCACTTTATCATGCTTAATGACACCA
AGAGGAATACAATTTATAATGCAGCAATCCAAAAGGCAGTTTGTTTGGGGTCCAAAAGTGTTTTGGACATTGGAGCAGGAACTGGAATAC
TAAGCATGTTTGCTAAAAAAGCTGGAGCACATTCCGTGTATGCCTGTGAGTTATCCAAGACCATGTATGAACTTGCCTGTGATGTCGTGG
CAGCAAACAAGATGGAAGCAGGGATCAAACTCTTACATACGAAGTCACTTGACATAGAGATTCCAAAACATATTCCCGAAAGAGTGTCCC
TAGTTGTAACAGAAACTGTCGATGCAGGTTTATTTGGAGAAGGAATTGTGGAGAGTTTGATTCATGCATGGGAGCATTTACTTTTACAGC
CAAAGACCAAAGGTGAAAGTGCTAATTGTGAAAAGTATGGGAAAGTTATACCAGCAAGTGCTGTTATATTTGGGATGGCAGTAGAATGTG
CAGAGATAAGAAGACATCATAGAGTGGGTATTAAGGACATTGCTGGTATCCATTTGCCAACAAATGTGAAATTTCAGAGTCCGGCTTATT
CTTCTGTAGATACTGAAGAAACAATTGAACCTTATACAACTGAAAAGATGAGTCGAGTTCCTGGAGGATATTTGGCTTTGACAGAGTGCT
TTGAAATTATGACAGTAGATTTCAACAACCTTCAGGAATTAAAAAGTCTTGCAACTAAAAAGCCTGATAAGATTGGTATTCCTGTTATTA
AAGAAGGCATACTAGATGCTATTATGGTTTGGTTTGTGCTCCAGCTTGATGATGAACATAGTTTATCCACAAGTCCTAGTGAGGAAACAT
GTTGGGAACAGGCTGTCTACCCCGTACAGGACCTTGCAGACTACTGGATAAAGCCTGGAGACCATGTGATGATGGAAGTATCTTGTCAAG
ACTGTTACTTAAGAATCCAGAGTATTAGTGTCTTGGGTTTGGAATGTGAAATGGATGTTGCAAAAAGTTTTACCCAGAATAAAGACTTGT
TATCGTTAGGAAATGAGGCTGAACTTTGTAGTGCCCTCGCTAACCTTCAGACCAGTAAACCAGATGCTGTAGAGCAGACATGTATATTGG
AATCTACAGAAATTGCTTTGCTTAACAACATCCCATATCATGAAGGCTTTAAAATGGCAATGAGCAAAGTTTTGTCTTCACTGACTCCAG
AGAAACTGTATCAGACCATGGATACTCACTGTCAGAATGAGATGAGCTCTGGAACTGGACAGAGTAATACTGTACAGAACATCCTTGAAC
CTTTCTACGTGTTAGATGTGTCCGAAGGCTTCTCTGTTCTGCCTGTTATTGCTGGCACACTTGGGCAGGTTAAACCATACAGTTCTGTGG
AGAAAGACCAGCATCGTATTGCTCTGGACCTCATATCTGAAGCCAATCACTTTCCTAAAGAAACACTTGAGTTTTGGCTGAGACATGTGG
AGGATGAATCTGCTATGTTACAAAGGCCAAAATCAGACAAGTTATGGAGCATAATTATATTGGATGTCATTGAGCCATCTGGGCTCATTC
AGCAGGAAATAATGGAAAAAGCTGCAATATCCAGGTGTTTACTACAATCTGGAGGCAAGATCTTTCCTCAGTATGTGCTGATGTTTGGGT
TGCTTGTGGAATCACAGACACTCCTAGAGGAGAATGCTGTTCAAGGAACAGAACGTACTCTTGGATTAAATATAGCACCTTTTATTAACC
AGTTTCAGGTACCTATACGTGTATTTTTGGACCTATCCTCATTGCCCTGTATACCTTTAAGCAAGCCAGTGGAACTCTTAAGACTAGATT
TAATGACTCCGTATTTGAACACCTCTAACAGAGAAGTAAAGGTATACGTTTGTAAATCTGGAAGACTGACTGCTATTCCATTTTGGTATC
ATATGTACCTTGATGAAGAGATTAGGTTGGATACTTCAAGTGAAGCCTCCCACTGGAAACAAGCTGCAGTTGTTTTAGATAATCCCATCC
AGGTTGAAATGGGAGAGGAACTTGTACTCAGCATTCAGCATCACAAAAGCAATGTCAGCATCACAGTAAAGCAATGAAGAGCAGTTTTCC
AATGAAAACTGTGTAAATAGAGCATCAACAAGTACAAAATTCTTGTCTTAATTAGTGGGGGTATATAAAAATTCCTTGTAATGGTCAAAT
ATTTTTTAAAATTGACATTAATAAAGCATATTTTAAAAGATTCTAAATAAAAGGGTAGCATTATTATAGAAATACTGCTGCAGATTTGCT
TTCTGGAAAAGGATACATCACTAGTTTTTTAAATTAGGAAACTTCTTTTGCTCGATTTTACAGAATAGGGATTTTAAAAGTCTTATCGTT
ATTGACATGTGTAAGTAAAGCAAAACTTTACTTTTGTAGGCATCTTGGCCTTTTTTCTTAAATCCAAACTTGTAATTGGGAAACACTGAA
AGGCTTCCACTGAAGACTGAGGGTTATGGTTACCTGTAAATTCCAATCTTGCTTCCTTTAAATACTCAGTGTACATCTGAAACATCTCAG
GTTTTGTTTTGAGAATGCAAGCTTGAAAAAGAATTTAAGCTATAAGCTAAATGTAATTAAAACAGTAAAGGAGTTAGGGAATACATCTTC
AGGAGGCAGCATTTTTCTTGGTCTACTTTGGCAAAAGAACATTTAAAAGCTGGTAACAAAACAAAGTTAAATTGAAGGAAGACTTAATCC
TATACTATTTTTCAAAGTTTTGATTTGGATGTACAATAAGTACATTAATTGATCCAATTTTTACAAACTTTTGAAATAAAGGAAGATCAT

>28024_28024_3_EXT2-PRMT10_EXT2_chr11_44151688_ENST00000395673_PRMT10_chr4_148601622_ENST00000322396_length(amino acids)=1212AA_BP=430
MIPPRGMSCASGSGGGLRHPLRCQKPWDEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIE
SSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSD
YYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIP
VYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVL
RGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQETFQYTLFRWAEELDALSRI
QDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFSDAKENFYRVANWLVERWHFIMLNDTKRNTIYNAAIQKA
VCLGSKSVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMEAGIKLLHTKSLDIEIPKHIPERVSLVVTETVDAGLFG
EGIVESLIHAWEHLLLQPKTKGESANCEKYGKVIPASAVIFGMAVECAEIRRHHRVGIKDIAGIHLPTNVKFQSPAYSSVDTEETIEPYT
TEKMSRVPGGYLALTECFEIMTVDFNNLQELKSLATKKPDKIGIPVIKEGILDAIMVWFVLQLDDEHSLSTSPSEETCWEQAVYPVQDLA
DYWIKPGDHVMMEVSCQDCYLRIQSISVLGLECEMDVAKSFTQNKDLLSLGNEAELCSALANLQTSKPDAVEQTCILESTEIALLNNIPY
HEGFKMAMSKVLSSLTPEKLYQTMDTHCQNEMSSGTGQSNTVQNILEPFYVLDVSEGFSVLPVIAGTLGQVKPYSSVEKDQHRIALDLIS
EANHFPKETLEFWLRHVEDESAMLQRPKSDKLWSIIILDVIEPSGLIQQEIMEKAAISRCLLQSGGKIFPQYVLMFGLLVESQTLLEENA
VQGTERTLGLNIAPFINQFQVPIRVFLDLSSLPCIPLSKPVELLRLDLMTPYLNTSNREVKVYVCKSGRLTAIPFWYHMYLDEEIRLDTS

--------------------------------------------------------------
>28024_28024_4_EXT2-PRMT10_EXT2_chr11_44151688_ENST00000533608_PRMT10_chr4_148601622_ENST00000322396_length(transcript)=4603nt_BP=1507nt
CTGTCTGAGCATTTCACTGCGGAGCCTGAGCGCGCCTGCCTGGGAAAACACTGCAGCGGTGCTCGGACTCCTCCTGTCCAGCAGGAGGCG
CGGCCCGGCAGCTCCCGCATGCGCAGTGCGCTCGGTGTCAGACGGCCCGGATCCCGGTTACCGGCCCCTCGCTCGCTGCTCGCCAGCCCA
GACTCGGCCCTGGCAGTGGCGGCTGGCGATTCGGACCGATCCGACCTGGGCGGAGGTGGCCCGCGCCCCGCGGCATGAGCCGGTGACCAA
GCTCGGGGCCGAGCGGGAGGCAGCCGTGGCCGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGTCAAGTATAATAT
CCGGGGTCCTGCCCTCATCCCAAGAATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCTGGGCCTCATTGC
CACTGGCATGTTTCAGTTTTGGCCCCATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGATGTGCCGGTTGT
TAGGCTGCCAGCCGACAGTCCCATCCCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCGCTGTGGCTTCAA
CCCAAAGAACAAAATCAAGGTGTATATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACACCATCTCCCGGGA
GTATAATGAACTGCTCATGGCCATCTCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCCCTCCATCGATGT
GCTTAACCAGAACACACTGCGCATCAAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAATCACCTGTTGTT
CAACATGTTGCCTGGAGGTCCCCCAGATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGGCGGCTTTTCTAC
GTGGACTTACCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAAAGGACCAGGTCC
ACGGCAATACTTCCTCCTGTCATCTCAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAAACATGGAGAGTC
AGTGTTAGTACTCGATAAATGCACCAACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGTCTTCGATTACCC
ACAGGTGCTACAGGAGGCTACTTTCTGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTTACAAGCTGGCTG
TGTCCCGGTTGTCATTGCAGACTCCTATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGTACCAGAAGAAAA
GATGTCAGATGTGTACAGTATTTTGCAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGGAAACTTTTCAGTACACACTTTT
CAGATGGGCTGAAGAGCTTGATGCTCTCAGTCGGATACAAGACTTACTTGGTTGCTATGAGCAGGCCTTGGAACTGTTTCCTGATGATGA
AGTGATTTGCAATAGTATGGGGGAGCATCTCTTCAGAATGGGCTTTAGGGATGAAGCAGCTGGGTATTTTCATAAAGCAGTGAAGCTAAA
CCCTGATTTCAGTGATGCAAAGGAGAATTTTTATCGTGTTGCAAACTGGTTGGTGGAACGCTGGCACTTTATCATGCTTAATGACACCAA
GAGGAATACAATTTATAATGCAGCAATCCAAAAGGCAGTTTGTTTGGGGTCCAAAAGTGTTTTGGACATTGGAGCAGGAACTGGAATACT
AAGCATGTTTGCTAAAAAAGCTGGAGCACATTCCGTGTATGCCTGTGAGTTATCCAAGACCATGTATGAACTTGCCTGTGATGTCGTGGC
AGCAAACAAGATGGAAGCAGGGATCAAACTCTTACATACGAAGTCACTTGACATAGAGATTCCAAAACATATTCCCGAAAGAGTGTCCCT
AGTTGTAACAGAAACTGTCGATGCAGGTTTATTTGGAGAAGGAATTGTGGAGAGTTTGATTCATGCATGGGAGCATTTACTTTTACAGCC
AAAGACCAAAGGTGAAAGTGCTAATTGTGAAAAGTATGGGAAAGTTATACCAGCAAGTGCTGTTATATTTGGGATGGCAGTAGAATGTGC
AGAGATAAGAAGACATCATAGAGTGGGTATTAAGGACATTGCTGGTATCCATTTGCCAACAAATGTGAAATTTCAGAGTCCGGCTTATTC
TTCTGTAGATACTGAAGAAACAATTGAACCTTATACAACTGAAAAGATGAGTCGAGTTCCTGGAGGATATTTGGCTTTGACAGAGTGCTT
TGAAATTATGACAGTAGATTTCAACAACCTTCAGGAATTAAAAAGTCTTGCAACTAAAAAGCCTGATAAGATTGGTATTCCTGTTATTAA
AGAAGGCATACTAGATGCTATTATGGTTTGGTTTGTGCTCCAGCTTGATGATGAACATAGTTTATCCACAAGTCCTAGTGAGGAAACATG
TTGGGAACAGGCTGTCTACCCCGTACAGGACCTTGCAGACTACTGGATAAAGCCTGGAGACCATGTGATGATGGAAGTATCTTGTCAAGA
CTGTTACTTAAGAATCCAGAGTATTAGTGTCTTGGGTTTGGAATGTGAAATGGATGTTGCAAAAAGTTTTACCCAGAATAAAGACTTGTT
ATCGTTAGGAAATGAGGCTGAACTTTGTAGTGCCCTCGCTAACCTTCAGACCAGTAAACCAGATGCTGTAGAGCAGACATGTATATTGGA
ATCTACAGAAATTGCTTTGCTTAACAACATCCCATATCATGAAGGCTTTAAAATGGCAATGAGCAAAGTTTTGTCTTCACTGACTCCAGA
GAAACTGTATCAGACCATGGATACTCACTGTCAGAATGAGATGAGCTCTGGAACTGGACAGAGTAATACTGTACAGAACATCCTTGAACC
TTTCTACGTGTTAGATGTGTCCGAAGGCTTCTCTGTTCTGCCTGTTATTGCTGGCACACTTGGGCAGGTTAAACCATACAGTTCTGTGGA
GAAAGACCAGCATCGTATTGCTCTGGACCTCATATCTGAAGCCAATCACTTTCCTAAAGAAACACTTGAGTTTTGGCTGAGACATGTGGA
GGATGAATCTGCTATGTTACAAAGGCCAAAATCAGACAAGTTATGGAGCATAATTATATTGGATGTCATTGAGCCATCTGGGCTCATTCA
GCAGGAAATAATGGAAAAAGCTGCAATATCCAGGTGTTTACTACAATCTGGAGGCAAGATCTTTCCTCAGTATGTGCTGATGTTTGGGTT
GCTTGTGGAATCACAGACACTCCTAGAGGAGAATGCTGTTCAAGGAACAGAACGTACTCTTGGATTAAATATAGCACCTTTTATTAACCA
GTTTCAGGTACCTATACGTGTATTTTTGGACCTATCCTCATTGCCCTGTATACCTTTAAGCAAGCCAGTGGAACTCTTAAGACTAGATTT
AATGACTCCGTATTTGAACACCTCTAACAGAGAAGTAAAGGTATACGTTTGTAAATCTGGAAGACTGACTGCTATTCCATTTTGGTATCA
TATGTACCTTGATGAAGAGATTAGGTTGGATACTTCAAGTGAAGCCTCCCACTGGAAACAAGCTGCAGTTGTTTTAGATAATCCCATCCA
GGTTGAAATGGGAGAGGAACTTGTACTCAGCATTCAGCATCACAAAAGCAATGTCAGCATCACAGTAAAGCAATGAAGAGCAGTTTTCCA
ATGAAAACTGTGTAAATAGAGCATCAACAAGTACAAAATTCTTGTCTTAATTAGTGGGGGTATATAAAAATTCCTTGTAATGGTCAAATA
TTTTTTAAAATTGACATTAATAAAGCATATTTTAAAAGATTCTAAATAAAAGGGTAGCATTATTATAGAAATACTGCTGCAGATTTGCTT
TCTGGAAAAGGATACATCACTAGTTTTTTAAATTAGGAAACTTCTTTTGCTCGATTTTACAGAATAGGGATTTTAAAAGTCTTATCGTTA
TTGACATGTGTAAGTAAAGCAAAACTTTACTTTTGTAGGCATCTTGGCCTTTTTTCTTAAATCCAAACTTGTAATTGGGAAACACTGAAA
GGCTTCCACTGAAGACTGAGGGTTATGGTTACCTGTAAATTCCAATCTTGCTTCCTTTAAATACTCAGTGTACATCTGAAACATCTCAGG
TTTTGTTTTGAGAATGCAAGCTTGAAAAAGAATTTAAGCTATAAGCTAAATGTAATTAAAACAGTAAAGGAGTTAGGGAATACATCTTCA
GGAGGCAGCATTTTTCTTGGTCTACTTTGGCAAAAGAACATTTAAAAGCTGGTAACAAAACAAAGTTAAATTGAAGGAAGACTTAATCCT
ATACTATTTTTCAAAGTTTTGATTTGGATGTACAATAAGTACATTAATTGATCCAATTTTTACAAACTTTTGAAATAAAGGAAGATCATT

>28024_28024_4_EXT2-PRMT10_EXT2_chr11_44151688_ENST00000533608_PRMT10_chr4_148601622_ENST00000322396_length(amino acids)=1283AA_BP=501
MSISLRSLSAPAWENTAAVLGLLLSSRRRGPAAPACAVRSVSDGPDPGYRPLARCSPAQTRPWQWRLAIRTDPTWAEVARAPRHEPVTKL
GAEREAAVAEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIESSNDWNVEKRSIRDVPVVR
LPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDINRACLFVPSIDVL
NQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPR
QYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVLRGARLGQAVLSDVLQAGCV
PVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQETFQYTLFRWAEELDALSRIQDLLGCYEQALELFPDDEV
ICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFSDAKENFYRVANWLVERWHFIMLNDTKRNTIYNAAIQKAVCLGSKSVLDIGAGTGILS
MFAKKAGAHSVYACELSKTMYELACDVVAANKMEAGIKLLHTKSLDIEIPKHIPERVSLVVTETVDAGLFGEGIVESLIHAWEHLLLQPK
TKGESANCEKYGKVIPASAVIFGMAVECAEIRRHHRVGIKDIAGIHLPTNVKFQSPAYSSVDTEETIEPYTTEKMSRVPGGYLALTECFE
IMTVDFNNLQELKSLATKKPDKIGIPVIKEGILDAIMVWFVLQLDDEHSLSTSPSEETCWEQAVYPVQDLADYWIKPGDHVMMEVSCQDC
YLRIQSISVLGLECEMDVAKSFTQNKDLLSLGNEAELCSALANLQTSKPDAVEQTCILESTEIALLNNIPYHEGFKMAMSKVLSSLTPEK
LYQTMDTHCQNEMSSGTGQSNTVQNILEPFYVLDVSEGFSVLPVIAGTLGQVKPYSSVEKDQHRIALDLISEANHFPKETLEFWLRHVED
ESAMLQRPKSDKLWSIIILDVIEPSGLIQQEIMEKAAISRCLLQSGGKIFPQYVLMFGLLVESQTLLEENAVQGTERTLGLNIAPFINQF
QVPIRVFLDLSSLPCIPLSKPVELLRLDLMTPYLNTSNREVKVYVCKSGRLTAIPFWYHMYLDEEIRLDTSSEASHWKQAAVVLDNPIQV

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Fusion Gene PPI Analysis for EXT2-PRMT9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EXT2-PRMT9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EXT2-PRMT9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEXT2C1851413EXOSTOSES, MULTIPLE, TYPE II18CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneEXT2C4225248SEIZURES, SCOLIOSIS, AND MACROCEPHALY SYNDROME4GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneEXT2C0015306Hereditary Multiple Exostoses1CTD_human
HgeneEXT2C1832588Chromosome 11p11.2 Deletion Syndrome1ORPHANET