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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EYA2-MYLK2 (FusionGDB2 ID:HG2139TG85366)

Fusion Gene Summary for EYA2-MYLK2

check button Fusion gene summary
Fusion gene informationFusion gene name: EYA2-MYLK2
Fusion gene ID: hg2139tg85366
HgeneTgene
Gene symbol

EYA2

MYLK2

Gene ID

2139

85366

Gene nameEYA transcriptional coactivator and phosphatase 2myosin light chain kinase 2
SynonymsEAB1KMLC|MLCK|MLCK2|skMLCK
Cytomap('EYA2')('MYLK2')

20q13.12

20q11.21

Type of geneprotein-codingprotein-coding
Descriptioneyes absent homolog 2myosin light chain kinase 2, skeletal/cardiac musclemyosin light chain kinase 2, skeletal muscle
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000317304, ENST00000327619, 
ENST00000357410, ENST00000497428, 
Fusion gene scores* DoF score7 X 5 X 6=2101 X 1 X 1=1
# samples 101
** MAII scorelog2(10/210*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: EYA2 [Title/Abstract] AND MYLK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEYA2(45725807)-MYLK2(30418622), # samples:3
Anticipated loss of major functional domain due to fusion event.EYA2-MYLK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EYA2-MYLK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EYA2-MYLK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EYA2-MYLK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEYA2

GO:0016576

histone dephosphorylation

19351884

TgeneMYLK2

GO:0006941

striated muscle contraction

16448786

TgeneMYLK2

GO:0010628

positive regulation of gene expression

21556048

TgeneMYLK2

GO:0018107

peptidyl-threonine phosphorylation

21556048

TgeneMYLK2

GO:0032971

regulation of muscle filament sliding

16448786

TgeneMYLK2

GO:0035914

skeletal muscle cell differentiation

21556048

TgeneMYLK2

GO:0046777

protein autophosphorylation

21556048


check buttonFusion gene breakpoints across EYA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MYLK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-ND-A4WF-01AEYA2chr20

45725807

-MYLK2chr20

30418622

+
ChimerDB4UCSTCGA-ND-A4WF-01AEYA2chr20

45725807

+MYLK2chr20

30418622

+
ChimerDB4UCSTCGA-ND-A4WFEYA2chr20

45725807

+MYLK2chr20

30418622

+


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Fusion Gene ORF analysis for EYA2-MYLK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000317304ENST00000468730EYA2chr20

45725807

+MYLK2chr20

30418622

+
5CDS-3UTRENST00000327619ENST00000468730EYA2chr20

45725807

+MYLK2chr20

30418622

+
5CDS-3UTRENST00000357410ENST00000468730EYA2chr20

45725807

+MYLK2chr20

30418622

+
In-frameENST00000317304ENST00000375985EYA2chr20

45725807

+MYLK2chr20

30418622

+
In-frameENST00000317304ENST00000375994EYA2chr20

45725807

+MYLK2chr20

30418622

+
In-frameENST00000327619ENST00000375985EYA2chr20

45725807

+MYLK2chr20

30418622

+
In-frameENST00000327619ENST00000375994EYA2chr20

45725807

+MYLK2chr20

30418622

+
In-frameENST00000357410ENST00000375985EYA2chr20

45725807

+MYLK2chr20

30418622

+
In-frameENST00000357410ENST00000375994EYA2chr20

45725807

+MYLK2chr20

30418622

+
intron-3CDSENST00000497428ENST00000375985EYA2chr20

45725807

+MYLK2chr20

30418622

+
intron-3CDSENST00000497428ENST00000375994EYA2chr20

45725807

+MYLK2chr20

30418622

+
intron-3UTRENST00000497428ENST00000468730EYA2chr20

45725807

+MYLK2chr20

30418622

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357410EYA2chr2045725807+ENST00000375994MYLK2chr2030418622+27211262681828586
ENST00000357410EYA2chr2045725807+ENST00000375985MYLK2chr2030418622+27211262681828586
ENST00000327619EYA2chr2045725807+ENST00000375994MYLK2chr2030418622+27211262681828586
ENST00000327619EYA2chr2045725807+ENST00000375985MYLK2chr2030418622+27211262681828586
ENST00000317304EYA2chr2045725807+ENST00000375994MYLK2chr2030418622+2357898101464484
ENST00000317304EYA2chr2045725807+ENST00000375985MYLK2chr2030418622+2357898101464484

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357410ENST00000375994EYA2chr2045725807+MYLK2chr2030418622+0.0127202890.9872798
ENST00000357410ENST00000375985EYA2chr2045725807+MYLK2chr2030418622+0.0127202890.9872798
ENST00000327619ENST00000375994EYA2chr2045725807+MYLK2chr2030418622+0.0127202890.9872798
ENST00000327619ENST00000375985EYA2chr2045725807+MYLK2chr2030418622+0.0127202890.9872798
ENST00000317304ENST00000375994EYA2chr2045725807+MYLK2chr2030418622+0.0109740380.989026
ENST00000317304ENST00000375985EYA2chr2045725807+MYLK2chr2030418622+0.0109740380.989026

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Fusion Genomic Features for EYA2-MYLK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EYA2chr2045725807+MYLK2chr2030418621+6.40E-060.99999356
EYA2chr2045725807+MYLK2chr2030418621+6.40E-060.99999356
EYA2chr2045725807+MYLK2chr2030418621+6.40E-060.99999356
EYA2chr2045725807+MYLK2chr2030418621+6.40E-060.99999356

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EYA2-MYLK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:45725807/chr20:30418622)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMYLK2chr20:45725807chr20:30418622ENST00000375985713574_586408597.0RegionCalmodulin-binding
TgeneMYLK2chr20:45725807chr20:30418622ENST00000375994612574_586408597.0RegionCalmodulin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMYLK2chr20:45725807chr20:30418622ENST00000375985713261_268408597.0Compositional biasNote=Poly-Pro
TgeneMYLK2chr20:45725807chr20:30418622ENST00000375994612261_268408597.0Compositional biasNote=Poly-Pro
TgeneMYLK2chr20:45725807chr20:30418622ENST00000375985713285_540408597.0DomainProtein kinase
TgeneMYLK2chr20:45725807chr20:30418622ENST00000375994612285_540408597.0DomainProtein kinase
TgeneMYLK2chr20:45725807chr20:30418622ENST00000375985713291_299408597.0Nucleotide bindingATP
TgeneMYLK2chr20:45725807chr20:30418622ENST00000375994612291_299408597.0Nucleotide bindingATP


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Fusion Gene Sequence for EYA2-MYLK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28049_28049_1_EYA2-MYLK2_EYA2_chr20_45725807_ENST00000317304_MYLK2_chr20_30418622_ENST00000375985_length(transcript)=2357nt_BP=898nt
GTACAAGGAAATGGTAGAACTAGTGATCTCACCCAGCCTCACTGTAAACAGCGATTGTCTGGATAAACTGAAGTTTAACCGTGCTGACGC
TGCTGTGTGGACTCTGAGTGACAGACAAGGCATCACCAAATCGGCCCCCCTGAGAGTGTCCCAGCTCTTCTCCAGATCTTGCCCACGTGT
CCTCCCCCGCCAGCCTTCCACAGCCATGGCAGCCTACGGCCAGACGCAGTACAGTGCGGGGATCCAGCAGGCTACCCCCTATACAGCTTA
CCCACCTCCAGCACAAGCCTATGGAATCCCTTCCTACAGCATCAAGACAGAAGACAGCTTGAACCATTCCCCTGGCCAGAGTGGATTCCT
CAGCTATGGCTCCAGCTTCAGCACCTCACCCACTGGACAGAGCCCATACACCTACCAGATGCACGGCACAACAGGGTTCTATCAAGGAGG
AAATGGACTGGGCAACGCAGCCGGTTTCGGGAGTGTGCACCAGGACTATCCTTCCTACCCCGGCTTCCCCCAGAGCCAGTACCCCCAGTA
TTACGGCTCATCCTACAACCCTCCCTACGTCCCGGCCAGCAGCATCTGCCCTTCGCCCCTCTCCACGTCCACCTACGTCCTCCAGGAGGC
ATCTCACAACGTCCCCAACCAGAGTTCCGAGTCACTTGCTGGTGAATACAACACACACAATGGACCTTCCACACCAGCGAAAGAGGGAGA
CACAGACAGGCCGCACCGGGCCTCCGACGGGAAGCTCCGAGGCCGGTCTAAGAGGAGCAGTGACCCGTCCCCGGCAGGGGACAATGAGAT
TGAGCGTGTGTTCGTGTGGGACTTGGATGAGACAATAATTATTTTTCACTCCTTACTCACGGGGACATTTGCATCCAGATACGGGAAGCC
AGAGAACATCCTGTGTGTCAACACCACCGGGCATTTGGTGAAGATCATTGACTTTGGCCTGGCACGGAGGTATAACCCCAACGAGAAGCT
GAAGGTGAACTTTGGGACCCCAGAGTTCCTGTCACCTGAGGTGGTGAATTATGACCAAATCTCCGATAAGACAGACATGTGGAGTATGGG
GGTGATCACCTACATGCTGCTGAGCGGCCTCTCCCCCTTCCTGGGAGATGATGACACAGAGACCCTAAACAACGTTCTATCTGGCAACTG
GTACTTTGATGAAGAGACCTTTGAGGCCGTATCAGACGAGGCCAAAGACTTTGTCTCCAACCTCATCGTCAAGGACCAGAGGGCCCGGAT
GAACGCTGCCCAGTGTCTCGCCCATCCCTGGCTCAACAACCTGGCGGAGAAAGCCAAACGCTGTAACCGACGCCTTAAGTCCCAGATCTT
GCTTAAGAAATACCTCATGAAGAGGCGCTGGAAGAAAAACTTCATTGCTGTCAGCGCTGCCAACCGCTTCAAGAAGATCAGCAGCTCGGG
GGCACTGATGGCTCTGGGGGTCTGAGCCCTGGGCGCAGCTGAAGCCTGGACGCAGCCACACAGTGGCCGGGGCTGAAGCCACACAGCCCA
GAAGGCCAGAAAAGGCAGCCAGATCCCCAGGGCAGCCTCGTTAGGACAAGGCTGTGCCAGGCTGGGAGGCTCGGGGCTCCCCACGCCCCC
ATGCAGTGACCGCTTCCCCGATGTGAGCCGCCTCGGAGTGTGGCCTGGATCCATCCTGCTAGCACCTCCCCAGACAGGGCTCCAGCCTGT
CGGCCACACCCCAGACTCCAGGCCCCCGTTGAAGCCGCTCCCGGTTCCCTCCCCAGCTCCTCGTCTTTGAACTGCCGCCGCCGTGGTGAC
CCCTGCTTTGCCCCACTGGGAGAGTCCTTAGCCTGGGCCTCCTCCTAGCTGGAGTGCCATGGCTGGGGGGTCTCAGCATGTAGGGCTTCT
GTGGTTGTGGATGGGAGGCTCCTGGTGGGGCAGAAAGGCTGCAACGCTGATTCCTAAGGCCCAGCTGCCAGGGAAGACAGAGCAGGCTTT
GTGAGAGAGGACCTCCATGCCCCCGCCACCTCCCCACTCCAGCAGATAAGGCCGAGCCCACACCATCTGGCCCAGGCTGGCCCCCACCCA
CCTTCCTTGCGACCACCAACACACAGGAACTCTGTGTGAGAGAGAGGGCGCCCAGCCCAGGCCTGGTGGAGGGGGAGGGGAGAAGCCAAG
GGACACAGGAGACCACCCCCGAGCTTGCCTCAGGGCCAAGCCGGCCCAACCCAACCACTCGGGGCCCCCATCTTGGGGGTCACCCATGGC
CTCAGATGATGGGGTCAGCAGGCCCAGGAGAATTAGGAAGGCCATGGGGCAGCCTCCAGTCTGCTCTCAGCTTGTGCCTTGTAAATAAAT

>28049_28049_1_EYA2-MYLK2_EYA2_chr20_45725807_ENST00000317304_MYLK2_chr20_30418622_ENST00000375985_length(amino acids)=484AA_BP=296
MVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGIQQATPYTAYPPP
AQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTSPTGQSPYTYQMHGTTGFYQGGNGLGNAAGFGSVHQDYPSYPGFPQSQYPQYYGS
SYNPPYVPASSICPSPLSTSTYVLQEASHNVPNQSSESLAGEYNTHNGPSTPAKEGDTDRPHRASDGKLRGRSKRSSDPSPAGDNEIERV
FVWDLDETIIIFHSLLTGTFASRYGKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVIT
YMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKK

--------------------------------------------------------------
>28049_28049_2_EYA2-MYLK2_EYA2_chr20_45725807_ENST00000317304_MYLK2_chr20_30418622_ENST00000375994_length(transcript)=2357nt_BP=898nt
GTACAAGGAAATGGTAGAACTAGTGATCTCACCCAGCCTCACTGTAAACAGCGATTGTCTGGATAAACTGAAGTTTAACCGTGCTGACGC
TGCTGTGTGGACTCTGAGTGACAGACAAGGCATCACCAAATCGGCCCCCCTGAGAGTGTCCCAGCTCTTCTCCAGATCTTGCCCACGTGT
CCTCCCCCGCCAGCCTTCCACAGCCATGGCAGCCTACGGCCAGACGCAGTACAGTGCGGGGATCCAGCAGGCTACCCCCTATACAGCTTA
CCCACCTCCAGCACAAGCCTATGGAATCCCTTCCTACAGCATCAAGACAGAAGACAGCTTGAACCATTCCCCTGGCCAGAGTGGATTCCT
CAGCTATGGCTCCAGCTTCAGCACCTCACCCACTGGACAGAGCCCATACACCTACCAGATGCACGGCACAACAGGGTTCTATCAAGGAGG
AAATGGACTGGGCAACGCAGCCGGTTTCGGGAGTGTGCACCAGGACTATCCTTCCTACCCCGGCTTCCCCCAGAGCCAGTACCCCCAGTA
TTACGGCTCATCCTACAACCCTCCCTACGTCCCGGCCAGCAGCATCTGCCCTTCGCCCCTCTCCACGTCCACCTACGTCCTCCAGGAGGC
ATCTCACAACGTCCCCAACCAGAGTTCCGAGTCACTTGCTGGTGAATACAACACACACAATGGACCTTCCACACCAGCGAAAGAGGGAGA
CACAGACAGGCCGCACCGGGCCTCCGACGGGAAGCTCCGAGGCCGGTCTAAGAGGAGCAGTGACCCGTCCCCGGCAGGGGACAATGAGAT
TGAGCGTGTGTTCGTGTGGGACTTGGATGAGACAATAATTATTTTTCACTCCTTACTCACGGGGACATTTGCATCCAGATACGGGAAGCC
AGAGAACATCCTGTGTGTCAACACCACCGGGCATTTGGTGAAGATCATTGACTTTGGCCTGGCACGGAGGTATAACCCCAACGAGAAGCT
GAAGGTGAACTTTGGGACCCCAGAGTTCCTGTCACCTGAGGTGGTGAATTATGACCAAATCTCCGATAAGACAGACATGTGGAGTATGGG
GGTGATCACCTACATGCTGCTGAGCGGCCTCTCCCCCTTCCTGGGAGATGATGACACAGAGACCCTAAACAACGTTCTATCTGGCAACTG
GTACTTTGATGAAGAGACCTTTGAGGCCGTATCAGACGAGGCCAAAGACTTTGTCTCCAACCTCATCGTCAAGGACCAGAGGGCCCGGAT
GAACGCTGCCCAGTGTCTCGCCCATCCCTGGCTCAACAACCTGGCGGAGAAAGCCAAACGCTGTAACCGACGCCTTAAGTCCCAGATCTT
GCTTAAGAAATACCTCATGAAGAGGCGCTGGAAGAAAAACTTCATTGCTGTCAGCGCTGCCAACCGCTTCAAGAAGATCAGCAGCTCGGG
GGCACTGATGGCTCTGGGGGTCTGAGCCCTGGGCGCAGCTGAAGCCTGGACGCAGCCACACAGTGGCCGGGGCTGAAGCCACACAGCCCA
GAAGGCCAGAAAAGGCAGCCAGATCCCCAGGGCAGCCTCGTTAGGACAAGGCTGTGCCAGGCTGGGAGGCTCGGGGCTCCCCACGCCCCC
ATGCAGTGACCGCTTCCCCGATGTGAGCCGCCTCGGAGTGTGGCCTGGATCCATCCTGCTAGCACCTCCCCAGACAGGGCTCCAGCCTGT
CGGCCACACCCCAGACTCCAGGCCCCCGTTGAAGCCGCTCCCGGTTCCCTCCCCAGCTCCTCGTCTTTGAACTGCCGCCGCCGTGGTGAC
CCCTGCTTTGCCCCACTGGGAGAGTCCTTAGCCTGGGCCTCCTCCTAGCTGGAGTGCCATGGCTGGGGGGTCTCAGCATGTAGGGCTTCT
GTGGTTGTGGATGGGAGGCTCCTGGTGGGGCAGAAAGGCTGCAACGCTGATTCCTAAGGCCCAGCTGCCAGGGAAGACAGAGCAGGCTTT
GTGAGAGAGGACCTCCATGCCCCCGCCACCTCCCCACTCCAGCAGATAAGGCCGAGCCCACACCATCTGGCCCAGGCTGGCCCCCACCCA
CCTTCCTTGCGACCACCAACACACAGGAACTCTGTGTGAGAGAGAGGGCGCCCAGCCCAGGCCTGGTGGAGGGGGAGGGGAGAAGCCAAG
GGACACAGGAGACCACCCCCGAGCTTGCCTCAGGGCCAAGCCGGCCCAACCCAACCACTCGGGGCCCCCATCTTGGGGGTCACCCATGGC
CTCAGATGATGGGGTCAGCAGGCCCAGGAGAATTAGGAAGGCCATGGGGCAGCCTCCAGTCTGCTCTCAGCTTGTGCCTTGTAAATAAAT

>28049_28049_2_EYA2-MYLK2_EYA2_chr20_45725807_ENST00000317304_MYLK2_chr20_30418622_ENST00000375994_length(amino acids)=484AA_BP=296
MVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGIQQATPYTAYPPP
AQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTSPTGQSPYTYQMHGTTGFYQGGNGLGNAAGFGSVHQDYPSYPGFPQSQYPQYYGS
SYNPPYVPASSICPSPLSTSTYVLQEASHNVPNQSSESLAGEYNTHNGPSTPAKEGDTDRPHRASDGKLRGRSKRSSDPSPAGDNEIERV
FVWDLDETIIIFHSLLTGTFASRYGKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVIT
YMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKK

--------------------------------------------------------------
>28049_28049_3_EYA2-MYLK2_EYA2_chr20_45725807_ENST00000327619_MYLK2_chr20_30418622_ENST00000375985_length(transcript)=2721nt_BP=1262nt
GCGCGCTCTGCTCGGCTGCAGGCTCAGGAAGCGGCGCGGCGGCACGTGCTGGGCCAGAGCCCCGCGCCCTGCGTCCAGCCGCCGGGTGTG
TGCGCCCGCGTAGCCCAGCGTCGCGCCTCGGCGCCCCCACGCGCCCACGCAGCGGCGCGGGGACCCGGGCGGGGGCAGAGGGAGGGCCCG
GCCCAGGGAGGAGAAGGGGCCGGTCCTCCCGGCGCAGGCAGCAGCCGCGGCAGCCCAGGAGGCGGAGGCAGCGGCAACGGCAGAGACAGC
AACGTGCCCGCCGCAGTCAGCCCGGCCTCGTCGGACCCGCACCGGCCCGCCCGCCCGCCCGCACCGCGTCGGGGCGCCCTCTCCACTGCG
CGCGGTACAAGGAAATGGTAGAACTAGTGATCTCACCCAGCCTCACTGTAAACAGCGATTGTCTGGATAAACTGAAGTTTAACCGTGCTG
ACGCTGCTGTGTGGACTCTGAGTGACAGACAAGGCATCACCAAATCGGCCCCCCTGAGAGTGTCCCAGCTCTTCTCCAGATCTTGCCCAC
GTGTCCTCCCCCGCCAGCCTTCCACAGCCATGGCAGCCTACGGCCAGACGCAGTACAGTGCGGGGATCCAGCAGGCTACCCCCTATACAG
CTTACCCACCTCCAGCACAAGCCTATGGAATCCCTTCCTACAGCATCAAGACAGAAGACAGCTTGAACCATTCCCCTGGCCAGAGTGGAT
TCCTCAGCTATGGCTCCAGCTTCAGCACCTCACCCACTGGACAGAGCCCATACACCTACCAGATGCACGGCACAACAGGGTTCTATCAAG
GAGGAAATGGACTGGGCAACGCAGCCGGTTTCGGGAGTGTGCACCAGGACTATCCTTCCTACCCCGGCTTCCCCCAGAGCCAGTACCCCC
AGTATTACGGCTCATCCTACAACCCTCCCTACGTCCCGGCCAGCAGCATCTGCCCTTCGCCCCTCTCCACGTCCACCTACGTCCTCCAGG
AGGCATCTCACAACGTCCCCAACCAGAGTTCCGAGTCACTTGCTGGTGAATACAACACACACAATGGACCTTCCACACCAGCGAAAGAGG
GAGACACAGACAGGCCGCACCGGGCCTCCGACGGGAAGCTCCGAGGCCGGTCTAAGAGGAGCAGTGACCCGTCCCCGGCAGGGGACAATG
AGATTGAGCGTGTGTTCGTGTGGGACTTGGATGAGACAATAATTATTTTTCACTCCTTACTCACGGGGACATTTGCATCCAGATACGGGA
AGCCAGAGAACATCCTGTGTGTCAACACCACCGGGCATTTGGTGAAGATCATTGACTTTGGCCTGGCACGGAGGTATAACCCCAACGAGA
AGCTGAAGGTGAACTTTGGGACCCCAGAGTTCCTGTCACCTGAGGTGGTGAATTATGACCAAATCTCCGATAAGACAGACATGTGGAGTA
TGGGGGTGATCACCTACATGCTGCTGAGCGGCCTCTCCCCCTTCCTGGGAGATGATGACACAGAGACCCTAAACAACGTTCTATCTGGCA
ACTGGTACTTTGATGAAGAGACCTTTGAGGCCGTATCAGACGAGGCCAAAGACTTTGTCTCCAACCTCATCGTCAAGGACCAGAGGGCCC
GGATGAACGCTGCCCAGTGTCTCGCCCATCCCTGGCTCAACAACCTGGCGGAGAAAGCCAAACGCTGTAACCGACGCCTTAAGTCCCAGA
TCTTGCTTAAGAAATACCTCATGAAGAGGCGCTGGAAGAAAAACTTCATTGCTGTCAGCGCTGCCAACCGCTTCAAGAAGATCAGCAGCT
CGGGGGCACTGATGGCTCTGGGGGTCTGAGCCCTGGGCGCAGCTGAAGCCTGGACGCAGCCACACAGTGGCCGGGGCTGAAGCCACACAG
CCCAGAAGGCCAGAAAAGGCAGCCAGATCCCCAGGGCAGCCTCGTTAGGACAAGGCTGTGCCAGGCTGGGAGGCTCGGGGCTCCCCACGC
CCCCATGCAGTGACCGCTTCCCCGATGTGAGCCGCCTCGGAGTGTGGCCTGGATCCATCCTGCTAGCACCTCCCCAGACAGGGCTCCAGC
CTGTCGGCCACACCCCAGACTCCAGGCCCCCGTTGAAGCCGCTCCCGGTTCCCTCCCCAGCTCCTCGTCTTTGAACTGCCGCCGCCGTGG
TGACCCCTGCTTTGCCCCACTGGGAGAGTCCTTAGCCTGGGCCTCCTCCTAGCTGGAGTGCCATGGCTGGGGGGTCTCAGCATGTAGGGC
TTCTGTGGTTGTGGATGGGAGGCTCCTGGTGGGGCAGAAAGGCTGCAACGCTGATTCCTAAGGCCCAGCTGCCAGGGAAGACAGAGCAGG
CTTTGTGAGAGAGGACCTCCATGCCCCCGCCACCTCCCCACTCCAGCAGATAAGGCCGAGCCCACACCATCTGGCCCAGGCTGGCCCCCA
CCCACCTTCCTTGCGACCACCAACACACAGGAACTCTGTGTGAGAGAGAGGGCGCCCAGCCCAGGCCTGGTGGAGGGGGAGGGGAGAAGC
CAAGGGACACAGGAGACCACCCCCGAGCTTGCCTCAGGGCCAAGCCGGCCCAACCCAACCACTCGGGGCCCCCATCTTGGGGGTCACCCA
TGGCCTCAGATGATGGGGTCAGCAGGCCCAGGAGAATTAGGAAGGCCATGGGGCAGCCTCCAGTCTGCTCTCAGCTTGTGCCTTGTAAAT

>28049_28049_3_EYA2-MYLK2_EYA2_chr20_45725807_ENST00000327619_MYLK2_chr20_30418622_ENST00000375985_length(amino acids)=586AA_BP=398
MRPAAGCVRPRSPASRLGAPTRPRSGAGTRAGAEGGPGPGRRRGRSSRRRQQPRQPRRRRQRQRQRQQRARRSQPGLVGPAPARPPARTA
SGRPLHCARYKEMVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGI
QQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTSPTGQSPYTYQMHGTTGFYQGGNGLGNAAGFGSVHQDYPSYPG
FPQSQYPQYYGSSYNPPYVPASSICPSPLSTSTYVLQEASHNVPNQSSESLAGEYNTHNGPSTPAKEGDTDRPHRASDGKLRGRSKRSSD
PSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQIS
DKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRC

--------------------------------------------------------------
>28049_28049_4_EYA2-MYLK2_EYA2_chr20_45725807_ENST00000327619_MYLK2_chr20_30418622_ENST00000375994_length(transcript)=2721nt_BP=1262nt
GCGCGCTCTGCTCGGCTGCAGGCTCAGGAAGCGGCGCGGCGGCACGTGCTGGGCCAGAGCCCCGCGCCCTGCGTCCAGCCGCCGGGTGTG
TGCGCCCGCGTAGCCCAGCGTCGCGCCTCGGCGCCCCCACGCGCCCACGCAGCGGCGCGGGGACCCGGGCGGGGGCAGAGGGAGGGCCCG
GCCCAGGGAGGAGAAGGGGCCGGTCCTCCCGGCGCAGGCAGCAGCCGCGGCAGCCCAGGAGGCGGAGGCAGCGGCAACGGCAGAGACAGC
AACGTGCCCGCCGCAGTCAGCCCGGCCTCGTCGGACCCGCACCGGCCCGCCCGCCCGCCCGCACCGCGTCGGGGCGCCCTCTCCACTGCG
CGCGGTACAAGGAAATGGTAGAACTAGTGATCTCACCCAGCCTCACTGTAAACAGCGATTGTCTGGATAAACTGAAGTTTAACCGTGCTG
ACGCTGCTGTGTGGACTCTGAGTGACAGACAAGGCATCACCAAATCGGCCCCCCTGAGAGTGTCCCAGCTCTTCTCCAGATCTTGCCCAC
GTGTCCTCCCCCGCCAGCCTTCCACAGCCATGGCAGCCTACGGCCAGACGCAGTACAGTGCGGGGATCCAGCAGGCTACCCCCTATACAG
CTTACCCACCTCCAGCACAAGCCTATGGAATCCCTTCCTACAGCATCAAGACAGAAGACAGCTTGAACCATTCCCCTGGCCAGAGTGGAT
TCCTCAGCTATGGCTCCAGCTTCAGCACCTCACCCACTGGACAGAGCCCATACACCTACCAGATGCACGGCACAACAGGGTTCTATCAAG
GAGGAAATGGACTGGGCAACGCAGCCGGTTTCGGGAGTGTGCACCAGGACTATCCTTCCTACCCCGGCTTCCCCCAGAGCCAGTACCCCC
AGTATTACGGCTCATCCTACAACCCTCCCTACGTCCCGGCCAGCAGCATCTGCCCTTCGCCCCTCTCCACGTCCACCTACGTCCTCCAGG
AGGCATCTCACAACGTCCCCAACCAGAGTTCCGAGTCACTTGCTGGTGAATACAACACACACAATGGACCTTCCACACCAGCGAAAGAGG
GAGACACAGACAGGCCGCACCGGGCCTCCGACGGGAAGCTCCGAGGCCGGTCTAAGAGGAGCAGTGACCCGTCCCCGGCAGGGGACAATG
AGATTGAGCGTGTGTTCGTGTGGGACTTGGATGAGACAATAATTATTTTTCACTCCTTACTCACGGGGACATTTGCATCCAGATACGGGA
AGCCAGAGAACATCCTGTGTGTCAACACCACCGGGCATTTGGTGAAGATCATTGACTTTGGCCTGGCACGGAGGTATAACCCCAACGAGA
AGCTGAAGGTGAACTTTGGGACCCCAGAGTTCCTGTCACCTGAGGTGGTGAATTATGACCAAATCTCCGATAAGACAGACATGTGGAGTA
TGGGGGTGATCACCTACATGCTGCTGAGCGGCCTCTCCCCCTTCCTGGGAGATGATGACACAGAGACCCTAAACAACGTTCTATCTGGCA
ACTGGTACTTTGATGAAGAGACCTTTGAGGCCGTATCAGACGAGGCCAAAGACTTTGTCTCCAACCTCATCGTCAAGGACCAGAGGGCCC
GGATGAACGCTGCCCAGTGTCTCGCCCATCCCTGGCTCAACAACCTGGCGGAGAAAGCCAAACGCTGTAACCGACGCCTTAAGTCCCAGA
TCTTGCTTAAGAAATACCTCATGAAGAGGCGCTGGAAGAAAAACTTCATTGCTGTCAGCGCTGCCAACCGCTTCAAGAAGATCAGCAGCT
CGGGGGCACTGATGGCTCTGGGGGTCTGAGCCCTGGGCGCAGCTGAAGCCTGGACGCAGCCACACAGTGGCCGGGGCTGAAGCCACACAG
CCCAGAAGGCCAGAAAAGGCAGCCAGATCCCCAGGGCAGCCTCGTTAGGACAAGGCTGTGCCAGGCTGGGAGGCTCGGGGCTCCCCACGC
CCCCATGCAGTGACCGCTTCCCCGATGTGAGCCGCCTCGGAGTGTGGCCTGGATCCATCCTGCTAGCACCTCCCCAGACAGGGCTCCAGC
CTGTCGGCCACACCCCAGACTCCAGGCCCCCGTTGAAGCCGCTCCCGGTTCCCTCCCCAGCTCCTCGTCTTTGAACTGCCGCCGCCGTGG
TGACCCCTGCTTTGCCCCACTGGGAGAGTCCTTAGCCTGGGCCTCCTCCTAGCTGGAGTGCCATGGCTGGGGGGTCTCAGCATGTAGGGC
TTCTGTGGTTGTGGATGGGAGGCTCCTGGTGGGGCAGAAAGGCTGCAACGCTGATTCCTAAGGCCCAGCTGCCAGGGAAGACAGAGCAGG
CTTTGTGAGAGAGGACCTCCATGCCCCCGCCACCTCCCCACTCCAGCAGATAAGGCCGAGCCCACACCATCTGGCCCAGGCTGGCCCCCA
CCCACCTTCCTTGCGACCACCAACACACAGGAACTCTGTGTGAGAGAGAGGGCGCCCAGCCCAGGCCTGGTGGAGGGGGAGGGGAGAAGC
CAAGGGACACAGGAGACCACCCCCGAGCTTGCCTCAGGGCCAAGCCGGCCCAACCCAACCACTCGGGGCCCCCATCTTGGGGGTCACCCA
TGGCCTCAGATGATGGGGTCAGCAGGCCCAGGAGAATTAGGAAGGCCATGGGGCAGCCTCCAGTCTGCTCTCAGCTTGTGCCTTGTAAAT

>28049_28049_4_EYA2-MYLK2_EYA2_chr20_45725807_ENST00000327619_MYLK2_chr20_30418622_ENST00000375994_length(amino acids)=586AA_BP=398
MRPAAGCVRPRSPASRLGAPTRPRSGAGTRAGAEGGPGPGRRRGRSSRRRQQPRQPRRRRQRQRQRQQRARRSQPGLVGPAPARPPARTA
SGRPLHCARYKEMVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGI
QQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTSPTGQSPYTYQMHGTTGFYQGGNGLGNAAGFGSVHQDYPSYPG
FPQSQYPQYYGSSYNPPYVPASSICPSPLSTSTYVLQEASHNVPNQSSESLAGEYNTHNGPSTPAKEGDTDRPHRASDGKLRGRSKRSSD
PSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQIS
DKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRC

--------------------------------------------------------------
>28049_28049_5_EYA2-MYLK2_EYA2_chr20_45725807_ENST00000357410_MYLK2_chr20_30418622_ENST00000375985_length(transcript)=2721nt_BP=1262nt
GCGCGCTCTGCTCGGCTGCAGGCTCAGGAAGCGGCGCGGCGGCACGTGCTGGGCCAGAGCCCCGCGCCCTGCGTCCAGCCGCCGGGTGTG
TGCGCCCGCGTAGCCCAGCGTCGCGCCTCGGCGCCCCCACGCGCCCACGCAGCGGCGCGGGGACCCGGGCGGGGGCAGAGGGAGGGCCCG
GCCCAGGGAGGAGAAGGGGCCGGTCCTCCCGGCGCAGGCAGCAGCCGCGGCAGCCCAGGAGGCGGAGGCAGCGGCAACGGCAGAGACAGC
AACGTGCCCGCCGCAGTCAGCCCGGCCTCGTCGGACCCGCACCGGCCCGCCCGCCCGCCCGCACCGCGTCGGGGCGCCCTCTCCACTGCG
CGCGGTACAAGGAAATGGTAGAACTAGTGATCTCACCCAGCCTCACTGTAAACAGCGATTGTCTGGATAAACTGAAGTTTAACCGTGCTG
ACGCTGCTGTGTGGACTCTGAGTGACAGACAAGGCATCACCAAATCGGCCCCCCTGAGAGTGTCCCAGCTCTTCTCCAGATCTTGCCCAC
GTGTCCTCCCCCGCCAGCCTTCCACAGCCATGGCAGCCTACGGCCAGACGCAGTACAGTGCGGGGATCCAGCAGGCTACCCCCTATACAG
CTTACCCACCTCCAGCACAAGCCTATGGAATCCCTTCCTACAGCATCAAGACAGAAGACAGCTTGAACCATTCCCCTGGCCAGAGTGGAT
TCCTCAGCTATGGCTCCAGCTTCAGCACCTCACCCACTGGACAGAGCCCATACACCTACCAGATGCACGGCACAACAGGGTTCTATCAAG
GAGGAAATGGACTGGGCAACGCAGCCGGTTTCGGGAGTGTGCACCAGGACTATCCTTCCTACCCCGGCTTCCCCCAGAGCCAGTACCCCC
AGTATTACGGCTCATCCTACAACCCTCCCTACGTCCCGGCCAGCAGCATCTGCCCTTCGCCCCTCTCCACGTCCACCTACGTCCTCCAGG
AGGCATCTCACAACGTCCCCAACCAGAGTTCCGAGTCACTTGCTGGTGAATACAACACACACAATGGACCTTCCACACCAGCGAAAGAGG
GAGACACAGACAGGCCGCACCGGGCCTCCGACGGGAAGCTCCGAGGCCGGTCTAAGAGGAGCAGTGACCCGTCCCCGGCAGGGGACAATG
AGATTGAGCGTGTGTTCGTGTGGGACTTGGATGAGACAATAATTATTTTTCACTCCTTACTCACGGGGACATTTGCATCCAGATACGGGA
AGCCAGAGAACATCCTGTGTGTCAACACCACCGGGCATTTGGTGAAGATCATTGACTTTGGCCTGGCACGGAGGTATAACCCCAACGAGA
AGCTGAAGGTGAACTTTGGGACCCCAGAGTTCCTGTCACCTGAGGTGGTGAATTATGACCAAATCTCCGATAAGACAGACATGTGGAGTA
TGGGGGTGATCACCTACATGCTGCTGAGCGGCCTCTCCCCCTTCCTGGGAGATGATGACACAGAGACCCTAAACAACGTTCTATCTGGCA
ACTGGTACTTTGATGAAGAGACCTTTGAGGCCGTATCAGACGAGGCCAAAGACTTTGTCTCCAACCTCATCGTCAAGGACCAGAGGGCCC
GGATGAACGCTGCCCAGTGTCTCGCCCATCCCTGGCTCAACAACCTGGCGGAGAAAGCCAAACGCTGTAACCGACGCCTTAAGTCCCAGA
TCTTGCTTAAGAAATACCTCATGAAGAGGCGCTGGAAGAAAAACTTCATTGCTGTCAGCGCTGCCAACCGCTTCAAGAAGATCAGCAGCT
CGGGGGCACTGATGGCTCTGGGGGTCTGAGCCCTGGGCGCAGCTGAAGCCTGGACGCAGCCACACAGTGGCCGGGGCTGAAGCCACACAG
CCCAGAAGGCCAGAAAAGGCAGCCAGATCCCCAGGGCAGCCTCGTTAGGACAAGGCTGTGCCAGGCTGGGAGGCTCGGGGCTCCCCACGC
CCCCATGCAGTGACCGCTTCCCCGATGTGAGCCGCCTCGGAGTGTGGCCTGGATCCATCCTGCTAGCACCTCCCCAGACAGGGCTCCAGC
CTGTCGGCCACACCCCAGACTCCAGGCCCCCGTTGAAGCCGCTCCCGGTTCCCTCCCCAGCTCCTCGTCTTTGAACTGCCGCCGCCGTGG
TGACCCCTGCTTTGCCCCACTGGGAGAGTCCTTAGCCTGGGCCTCCTCCTAGCTGGAGTGCCATGGCTGGGGGGTCTCAGCATGTAGGGC
TTCTGTGGTTGTGGATGGGAGGCTCCTGGTGGGGCAGAAAGGCTGCAACGCTGATTCCTAAGGCCCAGCTGCCAGGGAAGACAGAGCAGG
CTTTGTGAGAGAGGACCTCCATGCCCCCGCCACCTCCCCACTCCAGCAGATAAGGCCGAGCCCACACCATCTGGCCCAGGCTGGCCCCCA
CCCACCTTCCTTGCGACCACCAACACACAGGAACTCTGTGTGAGAGAGAGGGCGCCCAGCCCAGGCCTGGTGGAGGGGGAGGGGAGAAGC
CAAGGGACACAGGAGACCACCCCCGAGCTTGCCTCAGGGCCAAGCCGGCCCAACCCAACCACTCGGGGCCCCCATCTTGGGGGTCACCCA
TGGCCTCAGATGATGGGGTCAGCAGGCCCAGGAGAATTAGGAAGGCCATGGGGCAGCCTCCAGTCTGCTCTCAGCTTGTGCCTTGTAAAT

>28049_28049_5_EYA2-MYLK2_EYA2_chr20_45725807_ENST00000357410_MYLK2_chr20_30418622_ENST00000375985_length(amino acids)=586AA_BP=398
MRPAAGCVRPRSPASRLGAPTRPRSGAGTRAGAEGGPGPGRRRGRSSRRRQQPRQPRRRRQRQRQRQQRARRSQPGLVGPAPARPPARTA
SGRPLHCARYKEMVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGI
QQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTSPTGQSPYTYQMHGTTGFYQGGNGLGNAAGFGSVHQDYPSYPG
FPQSQYPQYYGSSYNPPYVPASSICPSPLSTSTYVLQEASHNVPNQSSESLAGEYNTHNGPSTPAKEGDTDRPHRASDGKLRGRSKRSSD
PSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQIS
DKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRC

--------------------------------------------------------------
>28049_28049_6_EYA2-MYLK2_EYA2_chr20_45725807_ENST00000357410_MYLK2_chr20_30418622_ENST00000375994_length(transcript)=2721nt_BP=1262nt
GCGCGCTCTGCTCGGCTGCAGGCTCAGGAAGCGGCGCGGCGGCACGTGCTGGGCCAGAGCCCCGCGCCCTGCGTCCAGCCGCCGGGTGTG
TGCGCCCGCGTAGCCCAGCGTCGCGCCTCGGCGCCCCCACGCGCCCACGCAGCGGCGCGGGGACCCGGGCGGGGGCAGAGGGAGGGCCCG
GCCCAGGGAGGAGAAGGGGCCGGTCCTCCCGGCGCAGGCAGCAGCCGCGGCAGCCCAGGAGGCGGAGGCAGCGGCAACGGCAGAGACAGC
AACGTGCCCGCCGCAGTCAGCCCGGCCTCGTCGGACCCGCACCGGCCCGCCCGCCCGCCCGCACCGCGTCGGGGCGCCCTCTCCACTGCG
CGCGGTACAAGGAAATGGTAGAACTAGTGATCTCACCCAGCCTCACTGTAAACAGCGATTGTCTGGATAAACTGAAGTTTAACCGTGCTG
ACGCTGCTGTGTGGACTCTGAGTGACAGACAAGGCATCACCAAATCGGCCCCCCTGAGAGTGTCCCAGCTCTTCTCCAGATCTTGCCCAC
GTGTCCTCCCCCGCCAGCCTTCCACAGCCATGGCAGCCTACGGCCAGACGCAGTACAGTGCGGGGATCCAGCAGGCTACCCCCTATACAG
CTTACCCACCTCCAGCACAAGCCTATGGAATCCCTTCCTACAGCATCAAGACAGAAGACAGCTTGAACCATTCCCCTGGCCAGAGTGGAT
TCCTCAGCTATGGCTCCAGCTTCAGCACCTCACCCACTGGACAGAGCCCATACACCTACCAGATGCACGGCACAACAGGGTTCTATCAAG
GAGGAAATGGACTGGGCAACGCAGCCGGTTTCGGGAGTGTGCACCAGGACTATCCTTCCTACCCCGGCTTCCCCCAGAGCCAGTACCCCC
AGTATTACGGCTCATCCTACAACCCTCCCTACGTCCCGGCCAGCAGCATCTGCCCTTCGCCCCTCTCCACGTCCACCTACGTCCTCCAGG
AGGCATCTCACAACGTCCCCAACCAGAGTTCCGAGTCACTTGCTGGTGAATACAACACACACAATGGACCTTCCACACCAGCGAAAGAGG
GAGACACAGACAGGCCGCACCGGGCCTCCGACGGGAAGCTCCGAGGCCGGTCTAAGAGGAGCAGTGACCCGTCCCCGGCAGGGGACAATG
AGATTGAGCGTGTGTTCGTGTGGGACTTGGATGAGACAATAATTATTTTTCACTCCTTACTCACGGGGACATTTGCATCCAGATACGGGA
AGCCAGAGAACATCCTGTGTGTCAACACCACCGGGCATTTGGTGAAGATCATTGACTTTGGCCTGGCACGGAGGTATAACCCCAACGAGA
AGCTGAAGGTGAACTTTGGGACCCCAGAGTTCCTGTCACCTGAGGTGGTGAATTATGACCAAATCTCCGATAAGACAGACATGTGGAGTA
TGGGGGTGATCACCTACATGCTGCTGAGCGGCCTCTCCCCCTTCCTGGGAGATGATGACACAGAGACCCTAAACAACGTTCTATCTGGCA
ACTGGTACTTTGATGAAGAGACCTTTGAGGCCGTATCAGACGAGGCCAAAGACTTTGTCTCCAACCTCATCGTCAAGGACCAGAGGGCCC
GGATGAACGCTGCCCAGTGTCTCGCCCATCCCTGGCTCAACAACCTGGCGGAGAAAGCCAAACGCTGTAACCGACGCCTTAAGTCCCAGA
TCTTGCTTAAGAAATACCTCATGAAGAGGCGCTGGAAGAAAAACTTCATTGCTGTCAGCGCTGCCAACCGCTTCAAGAAGATCAGCAGCT
CGGGGGCACTGATGGCTCTGGGGGTCTGAGCCCTGGGCGCAGCTGAAGCCTGGACGCAGCCACACAGTGGCCGGGGCTGAAGCCACACAG
CCCAGAAGGCCAGAAAAGGCAGCCAGATCCCCAGGGCAGCCTCGTTAGGACAAGGCTGTGCCAGGCTGGGAGGCTCGGGGCTCCCCACGC
CCCCATGCAGTGACCGCTTCCCCGATGTGAGCCGCCTCGGAGTGTGGCCTGGATCCATCCTGCTAGCACCTCCCCAGACAGGGCTCCAGC
CTGTCGGCCACACCCCAGACTCCAGGCCCCCGTTGAAGCCGCTCCCGGTTCCCTCCCCAGCTCCTCGTCTTTGAACTGCCGCCGCCGTGG
TGACCCCTGCTTTGCCCCACTGGGAGAGTCCTTAGCCTGGGCCTCCTCCTAGCTGGAGTGCCATGGCTGGGGGGTCTCAGCATGTAGGGC
TTCTGTGGTTGTGGATGGGAGGCTCCTGGTGGGGCAGAAAGGCTGCAACGCTGATTCCTAAGGCCCAGCTGCCAGGGAAGACAGAGCAGG
CTTTGTGAGAGAGGACCTCCATGCCCCCGCCACCTCCCCACTCCAGCAGATAAGGCCGAGCCCACACCATCTGGCCCAGGCTGGCCCCCA
CCCACCTTCCTTGCGACCACCAACACACAGGAACTCTGTGTGAGAGAGAGGGCGCCCAGCCCAGGCCTGGTGGAGGGGGAGGGGAGAAGC
CAAGGGACACAGGAGACCACCCCCGAGCTTGCCTCAGGGCCAAGCCGGCCCAACCCAACCACTCGGGGCCCCCATCTTGGGGGTCACCCA
TGGCCTCAGATGATGGGGTCAGCAGGCCCAGGAGAATTAGGAAGGCCATGGGGCAGCCTCCAGTCTGCTCTCAGCTTGTGCCTTGTAAAT

>28049_28049_6_EYA2-MYLK2_EYA2_chr20_45725807_ENST00000357410_MYLK2_chr20_30418622_ENST00000375994_length(amino acids)=586AA_BP=398
MRPAAGCVRPRSPASRLGAPTRPRSGAGTRAGAEGGPGPGRRRGRSSRRRQQPRQPRRRRQRQRQRQQRARRSQPGLVGPAPARPPARTA
SGRPLHCARYKEMVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGI
QQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTSPTGQSPYTYQMHGTTGFYQGGNGLGNAAGFGSVHQDYPSYPG
FPQSQYPQYYGSSYNPPYVPASSICPSPLSTSTYVLQEASHNVPNQSSESLAGEYNTHNGPSTPAKEGDTDRPHRASDGKLRGRSKRSSD
PSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQIS
DKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EYA2-MYLK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EYA2-MYLK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EYA2-MYLK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0007194Hypertrophic Cardiomyopathy7CLINGEN
TgeneC3495498Cardiomyopathy, Familial Hypertrophic, 1 (disorder)2CTD_human;GENOMICS_ENGLAND;UNIPROT