Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ALB-FGA (FusionGDB2 ID:HG213TG2243)

Fusion Gene Summary for ALB-FGA

check button Fusion gene summary
Fusion gene informationFusion gene name: ALB-FGA
Fusion gene ID: hg213tg2243
HgeneTgene
Gene symbol

ALB

FGA

Gene ID

213

2243

Gene namealbuminfibrinogen alpha chain
SynonymsHSA|PRO0883|PRO0903|PRO1341Fib2
Cytomap('ALB')('FGA')

4q13.3

4q31.3

Type of geneprotein-codingprotein-coding
Descriptionserum albuminfibrinogen alpha chainfibrinogen, A alpha polypeptide
Modification date2020032920200315
UniProtAcc.

P02671

Ensembl transtripts involved in fusion geneENST00000505649, ENST00000295897, 
ENST00000401494, ENST00000415165, 
ENST00000503124, ENST00000509063, 
Fusion gene scores* DoF score66 X 51 X 5=168306 X 5 X 3=90
# samples 746
** MAII scorelog2(74/16830*10)=-4.507366095701
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALB [Title/Abstract] AND FGA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALB(74284002)-FGA(155507309), # samples:1
Anticipated loss of major functional domain due to fusion event.ALB-FGA seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ALB-FGA seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneALB

GO:0009267

cellular response to starvation

16245148

HgeneALB

GO:0043066

negative regulation of apoptotic process

16153637

HgeneALB

GO:0051659

maintenance of mitochondrion location

16153637

TgeneFGA

GO:0007160

cell-matrix adhesion

10903502

TgeneFGA

GO:0031639

plasminogen activation

16846481

TgeneFGA

GO:0034116

positive regulation of heterotypic cell-cell adhesion

8100742

TgeneFGA

GO:0034622

cellular protein-containing complex assembly

8910396

TgeneFGA

GO:0042730

fibrinolysis

16846481

TgeneFGA

GO:0043152

induction of bacterial agglutination

24367264

TgeneFGA

GO:0045907

positive regulation of vasoconstriction

15739255

TgeneFGA

GO:0045921

positive regulation of exocytosis

19193866

TgeneFGA

GO:0050714

positive regulation of protein secretion

19193866

TgeneFGA

GO:0051258

protein polymerization

12706644

TgeneFGA

GO:0051592

response to calcium ion

6777381

TgeneFGA

GO:0070374

positive regulation of ERK1 and ERK2 cascade

10903502|19193866

TgeneFGA

GO:0070527

platelet aggregation

6281794

TgeneFGA

GO:0072378

blood coagulation, fibrin clot formation

16846481

TgeneFGA

GO:0090277

positive regulation of peptide hormone secretion

19193866

TgeneFGA

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

10903502

TgeneFGA

GO:2000352

negative regulation of endothelial cell apoptotic process

10903502



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-EP-A3RK-11AALBchr4

74284002

+FGAchr4

155507309

-


Top

Fusion Gene ORF analysis for ALB-FGA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000505649ENST00000302053ALBchr4

74284002

+FGAchr4

155507309

-
3UTR-3CDSENST00000505649ENST00000403106ALBchr4

74284002

+FGAchr4

155507309

-
Frame-shiftENST00000295897ENST00000302053ALBchr4

74284002

+FGAchr4

155507309

-
Frame-shiftENST00000295897ENST00000403106ALBchr4

74284002

+FGAchr4

155507309

-
Frame-shiftENST00000401494ENST00000302053ALBchr4

74284002

+FGAchr4

155507309

-
Frame-shiftENST00000401494ENST00000403106ALBchr4

74284002

+FGAchr4

155507309

-
Frame-shiftENST00000415165ENST00000302053ALBchr4

74284002

+FGAchr4

155507309

-
Frame-shiftENST00000415165ENST00000403106ALBchr4

74284002

+FGAchr4

155507309

-
Frame-shiftENST00000503124ENST00000302053ALBchr4

74284002

+FGAchr4

155507309

-
Frame-shiftENST00000503124ENST00000403106ALBchr4

74284002

+FGAchr4

155507309

-
Frame-shiftENST00000509063ENST00000302053ALBchr4

74284002

+FGAchr4

155507309

-
Frame-shiftENST00000509063ENST00000403106ALBchr4

74284002

+FGAchr4

155507309

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for ALB-FGA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


Top

Fusion Protein Features for ALB-FGA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:74284002/:155507309)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FGA

P02671

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for ALB-FGA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ALB-FGA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ALB-FGA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFGAP02671DB00009AlteplaseBiotechApproved
TgeneFGAP02671DB00029AnistreplaseBiotechApproved
TgeneFGAP02671DB00031TenecteplaseBiotechApproved
TgeneFGAP02671DB11311ProthrombinCleavageBiotechApproved
TgeneFGAP02671DB11571Human thrombinActivatorBiotechApproved
TgeneFGAP02671DB11572Thrombin alfaActivatorBiotechApproved
TgeneFGAP02671DB14548Zinc sulfate, unspecified formBinderSmall moleculeApproved|Experimental
TgeneFGAP02671DB00015ReteplaseBiotechApproved|Investigational
TgeneFGAP02671DB01593ZincSmall moleculeApproved|Investigational
TgeneFGAP02671DB05099AncrodBiotechApproved|Investigational
TgeneFGAP02671DB11300ThrombinActivatorBiotechApproved|Investigational
TgeneFGAP02671DB13151Anti-inhibitor coagulant complexCleavageBiotechApproved|Investigational
TgeneFGAP02671DB14487Zinc acetateSmall moleculeApproved|Investigational
TgeneFGAP02671DB14533Zinc chlorideBinderSmall moleculeApproved|Investigational

Top

Related Diseases for ALB-FGA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALBC0033687Proteinuria9CTD_human
HgeneALBC0017658Glomerulonephritis8CTD_human
HgeneALBC0022658Kidney Diseases8CTD_human
HgeneALBC1704377Bright Disease8CTD_human
HgeneALBC0017665Membranous glomerulonephritis6CTD_human
HgeneALBC0027697Nephritis6CTD_human
HgeneALBC0086445Idiopathic Membranous Glomerulonephritis6CTD_human
HgeneALBC0342185Hyperthyroxinemia, Familial Dysalbuminemic6CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneALBC1704378Heymann Nephritis6CTD_human
HgeneALBC0022660Kidney Failure, Acute4CTD_human
HgeneALBC0027707Nephritis, Interstitial4CTD_human
HgeneALBC0038454Cerebrovascular accident4CTD_human
HgeneALBC0041349Nephritis, Tubulointerstitial4CTD_human
HgeneALBC0751956Acute Cerebrovascular Accidents4CTD_human
HgeneALBC1565662Acute Kidney Insufficiency4CTD_human
HgeneALBC2609414Acute kidney injury4CTD_human
HgeneALBC0023893Liver Cirrhosis, Experimental3CTD_human
HgeneALBC0025290Aseptic Meningitis3CTD_human
HgeneALBC0013221Drug toxicity2CTD_human
HgeneALBC0014544Epilepsy2CTD_human
HgeneALBC0019193Hepatitis, Toxic2CTD_human
HgeneALBC0020649Hypotension2CTD_human
HgeneALBC0023890Liver Cirrhosis2CTD_human
HgeneALBC0027726Nephrotic Syndrome2CTD_human
HgeneALBC0036830Serum Sickness2CTD_human
HgeneALBC0041755Adverse reaction to drug2CTD_human
HgeneALBC0086237Epilepsy, Cryptogenic2CTD_human
HgeneALBC0162557Liver Failure, Acute2CTD_human
HgeneALBC0236018Aura2CTD_human
HgeneALBC0239946Fibrosis, Liver2CTD_human
HgeneALBC0751111Awakening Epilepsy2CTD_human
HgeneALBC0860207Drug-Induced Liver Disease2CTD_human
HgeneALBC0878666Analbuminemia2ORPHANET
HgeneALBC1262760Hepatitis, Drug-Induced2CTD_human
HgeneALBC3658290Drug-Induced Acute Liver Injury2CTD_human
HgeneALBC4277682Chemical and Drug Induced Liver Injury2CTD_human
HgeneALBC4279912Chemically-Induced Liver Toxicity2CTD_human
HgeneALBC0002994Angioedema1CTD_human
HgeneALBC0003460Anuria1CTD_human
HgeneALBC0003865Arthritis, Adjuvant-Induced1CTD_human
HgeneALBC0004509Azoospermia1CTD_human
HgeneALBC0005398Cholestasis, Extrahepatic1CTD_human
HgeneALBC0006111Brain Diseases1CTD_human
HgeneALBC0007222Cardiovascular Diseases1CTD_human
HgeneALBC0007786Brain Ischemia1CTD_human
HgeneALBC0008312Primary biliary cirrhosis1CTD_human
HgeneALBC0011573Endogenous depression1CTD_human
HgeneALBC0011581Depressive disorder1CTD_human
HgeneALBC0011875Diabetic Angiopathies1CTD_human
HgeneALBC0011881Diabetic Nephropathy1CTD_human
HgeneALBC0013502Echinococcosis1CTD_human
HgeneALBC0014518Toxic Epidermal Necrolysis1CTD_human
HgeneALBC0016059Fibrosis1CTD_human
HgeneALBC0017662Glomerulonephritis, Membranoproliferative1CTD_human
HgeneALBC0017667Nodular glomerulosclerosis1CTD_human
HgeneALBC0018799Heart Diseases1CTD_human
HgeneALBC0018801Heart failure1CTD_human
HgeneALBC0018802Congestive heart failure1CTD_human
HgeneALBC0019061Hemolytic-Uremic Syndrome1CTD_human
HgeneALBC0019158Hepatitis1CTD_human
HgeneALBC0019209Hepatomegaly1CTD_human
HgeneALBC0019693HIV Infections1CTD_human
HgeneALBC0019699HIV Seropositivity1CTD_human
HgeneALBC0020517Hypersensitivity1CTD_human
HgeneALBC0020522Delayed Hypersensitivity1CTD_human
HgeneALBC0020538Hypertensive disease1CTD_human
HgeneALBC0022548Keloid1CTD_human
HgeneALBC0022661Kidney Failure, Chronic1CTD_human
HgeneALBC0023212Left-Sided Heart Failure1CTD_human
HgeneALBC0023892Biliary cirrhosis1CTD_human
HgeneALBC0024623Malignant neoplasm of stomach1CTD_human
HgeneALBC0025193Melancholia1CTD_human
HgeneALBC0025945Microangiopathy, Diabetic1CTD_human
HgeneALBC0026848Myopathy1CTD_human
HgeneALBC0027055Myocardial Reperfusion Injury1CTD_human
HgeneALBC0027720Nephrosis1CTD_human
HgeneALBC0028797Occupational Diseases1CTD_human
HgeneALBC0030193Pain1CTD_human
HgeneALBC0030286Pancreatic Diseases1CTD_human
HgeneALBC0030305Pancreatitis1CTD_human
HgeneALBC0035222Respiratory Distress Syndrome, Adult1CTD_human
HgeneALBC0035242Respiratory Tract Diseases1CTD_human
HgeneALBC0035457Rhinitis, Allergic, Perennial1CTD_human
HgeneALBC0038325Stevens-Johnson Syndrome1CTD_human
HgeneALBC0038356Stomach Neoplasms1CTD_human
HgeneALBC0040034Thrombocytopenia1CTD_human
HgeneALBC0041696Unipolar Depression1CTD_human
HgeneALBC0042109Urticaria1CTD_human
HgeneALBC0042164Uveitis1CTD_human
HgeneALBC0085584Encephalopathies1CTD_human
HgeneALBC0086133Depressive Syndrome1CTD_human
HgeneALBC0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneALBC0234230Pain, Burning1CTD_human
HgeneALBC0234238Ache1CTD_human
HgeneALBC0234254Radiating pain1CTD_human
HgeneALBC0235527Heart Failure, Right-Sided1CTD_human
HgeneALBC0238065Secondary Biliary Cholangitis1CTD_human
HgeneALBC0239981Hypoalbuminemia1CTD_human
HgeneALBC0268742Membranoproliferative Glomerulonephritis, Type I1CTD_human
HgeneALBC0268743Membranoproliferative Glomerulonephritis, Type II1CTD_human
HgeneALBC0273115Lung Injury1CTD_human
HgeneALBC0282126Depression, Neurotic1CTD_human
HgeneALBC0458257Pain, Splitting1CTD_human
HgeneALBC0458259Pain, Crushing1CTD_human
HgeneALBC0751407Pain, Migratory1CTD_human
HgeneALBC0751408Suffering, Physical1CTD_human
HgeneALBC0917798Cerebral Ischemia1CTD_human
HgeneALBC0971858Arthritis, Collagen-Induced1CTD_human
HgeneALBC0993582Arthritis, Experimental1CTD_human
HgeneALBC1274933Drug-Induced Stevens Johnson Syndrome1CTD_human
HgeneALBC1306571Hepatic Insufficiency1CTD_human
HgeneALBC1527304Allergic Reaction1CTD_human
HgeneALBC1623038Cirrhosis1CTD_human
HgeneALBC1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneALBC1720821Membranoproliferative Glomerulonephritis, Type III1CTD_human
HgeneALBC1959583Myocardial Failure1CTD_human
HgeneALBC1961112Heart Decompensation1CTD_human
HgeneALBC2350344Chronic Lung Injury1CTD_human
HgeneALBC3658301Mycoplasma-Induced Stevens-Johnson Syndrome1CTD_human
HgeneALBC3658302Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum1CTD_human
HgeneALBC4505456HIV Coinfection1CTD_human
HgeneALBC4551595Biliary Cirrhosis, Primary, 11CTD_human
HgeneALBC4553297Cystic Echinocccosis1CTD_human
TgeneC2584774Congenital hypofibrinogenemia8CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0272350Dysfibrinogenemia, Congenital5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0001733Afibrinogenemia4CTD_human
TgeneC4316812Fibrinogen Deficiency4CTD_human;GENOMICS_ENGLAND
TgeneC0268389Amyloidosis, familial visceral3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0022658Kidney Diseases2CTD_human
TgeneC0740340Amyloidosis, Familial2CTD_human
TgeneC0001787Osteoporosis, Age-Related1CTD_human
TgeneC0008370Cholestasis1CTD_human
TgeneC0013221Drug toxicity1CTD_human
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0026640Mouth Neoplasms1CTD_human
TgeneC0029456Osteoporosis1CTD_human
TgeneC0029459Osteoporosis, Senile1CTD_human
TgeneC0034065Pulmonary Embolism1CTD_human
TgeneC0038454Cerebrovascular accident1CTD_human
TgeneC0040053Thrombosis1CTD_human;GENOMICS_ENGLAND
TgeneC0041755Adverse reaction to drug1CTD_human
TgeneC0087086Thrombus1CTD_human
TgeneC0153381Malignant neoplasm of mouth1CTD_human
TgeneC0398623Thrombophilia1CTD_human;GENOMICS_ENGLAND
TgeneC0524702Pulmonary Thromboembolisms1CTD_human
TgeneC0751406Post-Traumatic Osteoporosis1CTD_human
TgeneC0751956Acute Cerebrovascular Accidents1CTD_human
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC1861172Venous Thromboembolism1CTD_human
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human