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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:ALB-SERPING1 (FusionGDB2 ID:HG213TG710)

Fusion Gene Summary for ALB-SERPING1

check button Fusion gene summary
Fusion gene informationFusion gene name: ALB-SERPING1
Fusion gene ID: hg213tg710
HgeneTgene
Gene symbol

ALB

SERPING1

Gene ID

213

710

Gene namealbuminserpin family G member 1
SynonymsHSA|PRO0883|PRO0903|PRO1341C1IN|C1INH|C1NH|HAE1|HAE2
Cytomap('ALB')('SERPING1')

4q13.3

11q12.1

Type of geneprotein-codingprotein-coding
Descriptionserum albuminplasma protease C1 inhibitorC1 esterase inhibitorC1-inhibiting factorC1-inhibitorcomplement component 1 inhibitorepididymis secretory sperm binding proteinserine/cysteine proteinase inhibitor clade G member 1serpin G1serpin peptidase inhibitor cla
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000505649, ENST00000295897, 
ENST00000401494, ENST00000415165, 
ENST00000503124, ENST00000509063, 
Fusion gene scores* DoF score66 X 51 X 5=1683011 X 13 X 6=858
# samples 7413
** MAII scorelog2(74/16830*10)=-4.507366095701
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/858*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALB [Title/Abstract] AND SERPING1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALB(74280802)-SERPING1(57382101), # samples:1
ALB(74280817)-SERPING1(57382085), # samples:1
ALB(74274476)-SERPING1(57381845), # samples:1
Anticipated loss of major functional domain due to fusion event.ALB-SERPING1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ALB-SERPING1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ALB-SERPING1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ALB-SERPING1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ALB-SERPING1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ALB-SERPING1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ALB-SERPING1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneALB

GO:0009267

cellular response to starvation

16245148

HgeneALB

GO:0043066

negative regulation of apoptotic process

16153637

HgeneALB

GO:0051659

maintenance of mitochondrion location

16153637

TgeneSERPING1

GO:0001869

negative regulation of complement activation, lectin pathway

10946292


check buttonFusion gene breakpoints across ALB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SERPING1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CHOLTCGA-W5-AA2R-11AALBchr4

74280802

-SERPING1chr11

57382101

+
ChimerDB4CHOLTCGA-ZU-A8S4-11AALBchr4

74280817

-SERPING1chr11

57382085

+
ChiTaRS5.0N/ABP294362ALBchr4

74274476

+SERPING1chr11

57381845

+


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Fusion Gene ORF analysis for ALB-SERPING1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000505649ENST00000278407ALBchr4

74274476

+SERPING1chr11

57381845

+
3UTR-3CDSENST00000505649ENST00000340687ALBchr4

74274476

+SERPING1chr11

57381845

+
3UTR-3CDSENST00000505649ENST00000378323ALBchr4

74274476

+SERPING1chr11

57381845

+
3UTR-3CDSENST00000505649ENST00000378324ALBchr4

74274476

+SERPING1chr11

57381845

+
3UTR-3CDSENST00000505649ENST00000403558ALBchr4

74274476

+SERPING1chr11

57381845

+
3UTR-3UTRENST00000505649ENST00000278407ALBchr4

74280802

-SERPING1chr11

57382101

+
3UTR-3UTRENST00000505649ENST00000278407ALBchr4

74280817

-SERPING1chr11

57382085

+
3UTR-3UTRENST00000505649ENST00000340687ALBchr4

74280802

-SERPING1chr11

57382101

+
3UTR-3UTRENST00000505649ENST00000340687ALBchr4

74280817

-SERPING1chr11

57382085

+
3UTR-3UTRENST00000505649ENST00000378323ALBchr4

74280802

-SERPING1chr11

57382101

+
3UTR-3UTRENST00000505649ENST00000378323ALBchr4

74280817

-SERPING1chr11

57382085

+
3UTR-3UTRENST00000505649ENST00000378324ALBchr4

74280802

-SERPING1chr11

57382101

+
3UTR-3UTRENST00000505649ENST00000378324ALBchr4

74280817

-SERPING1chr11

57382085

+
3UTR-3UTRENST00000505649ENST00000403558ALBchr4

74280802

-SERPING1chr11

57382101

+
3UTR-3UTRENST00000505649ENST00000403558ALBchr4

74280817

-SERPING1chr11

57382085

+
3UTR-intronENST00000505649ENST00000531605ALBchr4

74280802

-SERPING1chr11

57382101

+
3UTR-intronENST00000505649ENST00000531605ALBchr4

74280817

-SERPING1chr11

57382085

+
3UTR-intronENST00000505649ENST00000531605ALBchr4

74274476

+SERPING1chr11

57381845

+
5CDS-3UTRENST00000295897ENST00000278407ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000295897ENST00000278407ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000295897ENST00000340687ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000295897ENST00000340687ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000295897ENST00000378323ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000295897ENST00000378323ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000295897ENST00000378324ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000295897ENST00000378324ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000295897ENST00000403558ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000295897ENST00000403558ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000401494ENST00000278407ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000401494ENST00000278407ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000401494ENST00000340687ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000401494ENST00000340687ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000401494ENST00000378323ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000401494ENST00000378323ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000401494ENST00000378324ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000401494ENST00000378324ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000401494ENST00000403558ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000401494ENST00000403558ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000415165ENST00000278407ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000415165ENST00000278407ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000415165ENST00000340687ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000415165ENST00000340687ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000415165ENST00000378323ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000415165ENST00000378323ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000415165ENST00000378324ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000415165ENST00000378324ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000415165ENST00000403558ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000415165ENST00000403558ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000503124ENST00000278407ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000503124ENST00000278407ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000503124ENST00000340687ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000503124ENST00000340687ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000503124ENST00000378323ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000503124ENST00000378323ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000503124ENST00000378324ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000503124ENST00000378324ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000503124ENST00000403558ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000503124ENST00000403558ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000509063ENST00000278407ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000509063ENST00000278407ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000509063ENST00000340687ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000509063ENST00000340687ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000509063ENST00000378323ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000509063ENST00000378323ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000509063ENST00000378324ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000509063ENST00000378324ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-3UTRENST00000509063ENST00000403558ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-3UTRENST00000509063ENST00000403558ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-intronENST00000295897ENST00000531605ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-intronENST00000295897ENST00000531605ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-intronENST00000295897ENST00000531605ALBchr4

74274476

+SERPING1chr11

57381845

+
5CDS-intronENST00000401494ENST00000531605ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-intronENST00000401494ENST00000531605ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-intronENST00000415165ENST00000531605ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-intronENST00000415165ENST00000531605ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-intronENST00000503124ENST00000531605ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-intronENST00000503124ENST00000531605ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-intronENST00000509063ENST00000531605ALBchr4

74280802

-SERPING1chr11

57382101

+
5CDS-intronENST00000509063ENST00000531605ALBchr4

74280817

-SERPING1chr11

57382085

+
5CDS-intronENST00000509063ENST00000531605ALBchr4

74274476

+SERPING1chr11

57381845

+
Frame-shiftENST00000295897ENST00000278407ALBchr4

74274476

+SERPING1chr11

57381845

+
Frame-shiftENST00000295897ENST00000378323ALBchr4

74274476

+SERPING1chr11

57381845

+
Frame-shiftENST00000295897ENST00000378324ALBchr4

74274476

+SERPING1chr11

57381845

+
Frame-shiftENST00000295897ENST00000403558ALBchr4

74274476

+SERPING1chr11

57381845

+
Frame-shiftENST00000509063ENST00000278407ALBchr4

74274476

+SERPING1chr11

57381845

+
Frame-shiftENST00000509063ENST00000378323ALBchr4

74274476

+SERPING1chr11

57381845

+
Frame-shiftENST00000509063ENST00000378324ALBchr4

74274476

+SERPING1chr11

57381845

+
Frame-shiftENST00000509063ENST00000403558ALBchr4

74274476

+SERPING1chr11

57381845

+
In-frameENST00000295897ENST00000340687ALBchr4

74274476

+SERPING1chr11

57381845

+
In-frameENST00000509063ENST00000340687ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000401494ENST00000278407ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000401494ENST00000340687ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000401494ENST00000378323ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000401494ENST00000378324ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000401494ENST00000403558ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000415165ENST00000278407ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000415165ENST00000340687ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000415165ENST00000378323ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000415165ENST00000378324ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000415165ENST00000403558ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000503124ENST00000278407ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000503124ENST00000340687ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000503124ENST00000378323ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000503124ENST00000378324ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-3CDSENST00000503124ENST00000403558ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-intronENST00000401494ENST00000531605ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-intronENST00000415165ENST00000531605ALBchr4

74274476

+SERPING1chr11

57381845

+
intron-intronENST00000503124ENST00000531605ALBchr4

74274476

+SERPING1chr11

57381845

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000295897ALBchr474274476+ENST00000340687SERPING1chr1157381845+879405465836123
ENST00000509063ALBchr474274476+ENST00000340687SERPING1chr1157381845+814340400771123

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000295897ENST00000340687ALBchr474274476+SERPING1chr1157381845+0.035943660.9640563
ENST00000509063ENST00000340687ALBchr474274476+SERPING1chr1157381845+0.0356668760.9643332

Top

Fusion Genomic Features for ALB-SERPING1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for ALB-SERPING1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:74280802/chr11:57382101)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSERPING1chr4:74274476chr11:57381845ENST000002784070885_1190501.0RegionNote=7 X 4 AA tandem repeats of [QE]-P-T-[TQ]
TgeneSERPING1chr4:74274476chr11:57381845ENST0000027840708101_1040501.0RepeatNote=5
TgeneSERPING1chr4:74274476chr11:57381845ENST0000027840708105_1080501.0RepeatNote=6
TgeneSERPING1chr4:74274476chr11:57381845ENST0000027840708116_1190501.0RepeatNote=7
TgeneSERPING1chr4:74274476chr11:57381845ENST000002784070885_880501.0RepeatNote=1
TgeneSERPING1chr4:74274476chr11:57381845ENST000002784070889_920501.0RepeatNote=2
TgeneSERPING1chr4:74274476chr11:57381845ENST000002784070893_960501.0RepeatNote=3
TgeneSERPING1chr4:74274476chr11:57381845ENST000002784070897_1000501.0RepeatNote=4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneALBchr4:74274476chr11:57381845ENST00000295897+11519_2100661.0DomainAlbumin 1
HgeneALBchr4:74274476chr11:57381845ENST00000295897+115211_4030661.0DomainAlbumin 2
HgeneALBchr4:74274476chr11:57381845ENST00000295897+115404_6010661.0DomainAlbumin 3
HgeneALBchr4:74274476chr11:57381845ENST00000509063+11419_2100605.0DomainAlbumin 1
HgeneALBchr4:74274476chr11:57381845ENST00000509063+114211_4030605.0DomainAlbumin 2
HgeneALBchr4:74274476chr11:57381845ENST00000509063+114404_6010605.0DomainAlbumin 3


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Fusion Gene Sequence for ALB-SERPING1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3791_3791_1_ALB-SERPING1_ALB_chr4_74274476_ENST00000295897_SERPING1_chr11_57381845_ENST00000340687_length(transcript)=879nt_BP=405nt
AATTATTGGTTAAAGAAGTATATTAGTGCTAATTTCCCTCCGTTTGTCCTAGCTTTTCTCTTCTGTCAACCCCACACGCCTTTGGCACAA
TGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGTGTGTTTCGTCGAGATGCACACAAGAGTGAGG
TTGCTCATCGGTTTAAAGATTTGGGAGAAGAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTTG
AAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGATGAGTCAGCTGAAAATTGTGACAAATCACTTT
GATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAAAAAGGACCCAGATCTTCAGGTTTCTGCGATGCAGCACCAGACAGTGC
TGGAACTGACAGAGACTGGGGTGGAGGCGGCTGCAGCCTCCGCCATCTCTGTGGCCCGCACCCTGCTGGTCTTTGAAGTGCAGCAGCCCT
TCCTCTTCGTGCTCTGGGACCAGCAGCACAAGTTCCCTGTCTTCATGGGGCGAGTATATGACCCCAGGGCCTGAGACCTGCAGGATCAGG
TTAGGGCGAGCGCTACCTCTCCAGCCTCAGCTCTCAGTTGCAGCCCTGCTGCTGCCTGCCTGGACTTGGCCCCTGCCACCTCCTGCCTCA
GGTGTCCGCTATCCACCAAAAGGGCTCCCTGAGGGTCTGGGCAAGGGACCTGCTTCTATTAGCCCTTCTCCATGGCCCTGCCATGCTCTC

>3791_3791_1_ALB-SERPING1_ALB_chr4_74274476_ENST00000295897_SERPING1_chr11_57381845_ENST00000340687_length(amino acids)=123AA_BP=
MGWRRLQPPPSLWPAPCWSLKCSSPSSSCSGTSSTSSLSSWGEYMTPGPETCRIRLGRALPLQPQLSVAALLLPAWTWPLPPPASGVRYP

--------------------------------------------------------------
>3791_3791_2_ALB-SERPING1_ALB_chr4_74274476_ENST00000509063_SERPING1_chr11_57381845_ENST00000340687_length(transcript)=814nt_BP=340nt
TCAACCCCACACGCCTTTGGCACAATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGTGTGTTT
CGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAAGAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCT
CAGTATCTTCAGCAGTGTCCATTTGAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGATGAGTCA
GCTGAAAATTGTGACAAATCACTTTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAAAAAGGACCCAGATCTTCAGGTT
TCTGCGATGCAGCACCAGACAGTGCTGGAACTGACAGAGACTGGGGTGGAGGCGGCTGCAGCCTCCGCCATCTCTGTGGCCCGCACCCTG
CTGGTCTTTGAAGTGCAGCAGCCCTTCCTCTTCGTGCTCTGGGACCAGCAGCACAAGTTCCCTGTCTTCATGGGGCGAGTATATGACCCC
AGGGCCTGAGACCTGCAGGATCAGGTTAGGGCGAGCGCTACCTCTCCAGCCTCAGCTCTCAGTTGCAGCCCTGCTGCTGCCTGCCTGGAC
TTGGCCCCTGCCACCTCCTGCCTCAGGTGTCCGCTATCCACCAAAAGGGCTCCCTGAGGGTCTGGGCAAGGGACCTGCTTCTATTAGCCC
TTCTCCATGGCCCTGCCATGCTCTCCAAACCACTTTTTGCAGCTTTCTCTAGTTCAAGTTCACCAGACTCTATAAATAAAACCTGACAGA

>3791_3791_2_ALB-SERPING1_ALB_chr4_74274476_ENST00000509063_SERPING1_chr11_57381845_ENST00000340687_length(amino acids)=123AA_BP=
MGWRRLQPPPSLWPAPCWSLKCSSPSSSCSGTSSTSSLSSWGEYMTPGPETCRIRLGRALPLQPQLSVAALLLPAWTWPLPPPASGVRYP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ALB-SERPING1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ALB-SERPING1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ALB-SERPING1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALBC0033687Proteinuria9CTD_human
HgeneALBC0017658Glomerulonephritis8CTD_human
HgeneALBC0022658Kidney Diseases8CTD_human
HgeneALBC1704377Bright Disease8CTD_human
HgeneALBC0017665Membranous glomerulonephritis6CTD_human
HgeneALBC0027697Nephritis6CTD_human
HgeneALBC0086445Idiopathic Membranous Glomerulonephritis6CTD_human
HgeneALBC0342185Hyperthyroxinemia, Familial Dysalbuminemic6CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneALBC1704378Heymann Nephritis6CTD_human
HgeneALBC0022660Kidney Failure, Acute4CTD_human
HgeneALBC0027707Nephritis, Interstitial4CTD_human
HgeneALBC0038454Cerebrovascular accident4CTD_human
HgeneALBC0041349Nephritis, Tubulointerstitial4CTD_human
HgeneALBC0751956Acute Cerebrovascular Accidents4CTD_human
HgeneALBC1565662Acute Kidney Insufficiency4CTD_human
HgeneALBC2609414Acute kidney injury4CTD_human
HgeneALBC0023893Liver Cirrhosis, Experimental3CTD_human
HgeneALBC0025290Aseptic Meningitis3CTD_human
HgeneALBC0013221Drug toxicity2CTD_human
HgeneALBC0014544Epilepsy2CTD_human
HgeneALBC0019193Hepatitis, Toxic2CTD_human
HgeneALBC0020649Hypotension2CTD_human
HgeneALBC0023890Liver Cirrhosis2CTD_human
HgeneALBC0027726Nephrotic Syndrome2CTD_human
HgeneALBC0036830Serum Sickness2CTD_human
HgeneALBC0041755Adverse reaction to drug2CTD_human
HgeneALBC0086237Epilepsy, Cryptogenic2CTD_human
HgeneALBC0162557Liver Failure, Acute2CTD_human
HgeneALBC0236018Aura2CTD_human
HgeneALBC0239946Fibrosis, Liver2CTD_human
HgeneALBC0751111Awakening Epilepsy2CTD_human
HgeneALBC0860207Drug-Induced Liver Disease2CTD_human
HgeneALBC0878666Analbuminemia2ORPHANET
HgeneALBC1262760Hepatitis, Drug-Induced2CTD_human
HgeneALBC3658290Drug-Induced Acute Liver Injury2CTD_human
HgeneALBC4277682Chemical and Drug Induced Liver Injury2CTD_human
HgeneALBC4279912Chemically-Induced Liver Toxicity2CTD_human
HgeneALBC0002994Angioedema1CTD_human
HgeneALBC0003460Anuria1CTD_human
HgeneALBC0003865Arthritis, Adjuvant-Induced1CTD_human
HgeneALBC0004509Azoospermia1CTD_human
HgeneALBC0005398Cholestasis, Extrahepatic1CTD_human
HgeneALBC0006111Brain Diseases1CTD_human
HgeneALBC0007222Cardiovascular Diseases1CTD_human
HgeneALBC0007786Brain Ischemia1CTD_human
HgeneALBC0008312Primary biliary cirrhosis1CTD_human
HgeneALBC0011573Endogenous depression1CTD_human
HgeneALBC0011581Depressive disorder1CTD_human
HgeneALBC0011875Diabetic Angiopathies1CTD_human
HgeneALBC0011881Diabetic Nephropathy1CTD_human
HgeneALBC0013502Echinococcosis1CTD_human
HgeneALBC0014518Toxic Epidermal Necrolysis1CTD_human
HgeneALBC0016059Fibrosis1CTD_human
HgeneALBC0017662Glomerulonephritis, Membranoproliferative1CTD_human
HgeneALBC0017667Nodular glomerulosclerosis1CTD_human
HgeneALBC0018799Heart Diseases1CTD_human
HgeneALBC0018801Heart failure1CTD_human
HgeneALBC0018802Congestive heart failure1CTD_human
HgeneALBC0019061Hemolytic-Uremic Syndrome1CTD_human
HgeneALBC0019158Hepatitis1CTD_human
HgeneALBC0019209Hepatomegaly1CTD_human
HgeneALBC0019693HIV Infections1CTD_human
HgeneALBC0019699HIV Seropositivity1CTD_human
HgeneALBC0020517Hypersensitivity1CTD_human
HgeneALBC0020522Delayed Hypersensitivity1CTD_human
HgeneALBC0020538Hypertensive disease1CTD_human
HgeneALBC0022548Keloid1CTD_human
HgeneALBC0022661Kidney Failure, Chronic1CTD_human
HgeneALBC0023212Left-Sided Heart Failure1CTD_human
HgeneALBC0023892Biliary cirrhosis1CTD_human
HgeneALBC0024623Malignant neoplasm of stomach1CTD_human
HgeneALBC0025193Melancholia1CTD_human
HgeneALBC0025945Microangiopathy, Diabetic1CTD_human
HgeneALBC0026848Myopathy1CTD_human
HgeneALBC0027055Myocardial Reperfusion Injury1CTD_human
HgeneALBC0027720Nephrosis1CTD_human
HgeneALBC0028797Occupational Diseases1CTD_human
HgeneALBC0030193Pain1CTD_human
HgeneALBC0030286Pancreatic Diseases1CTD_human
HgeneALBC0030305Pancreatitis1CTD_human
HgeneALBC0035222Respiratory Distress Syndrome, Adult1CTD_human
HgeneALBC0035242Respiratory Tract Diseases1CTD_human
HgeneALBC0035457Rhinitis, Allergic, Perennial1CTD_human
HgeneALBC0038325Stevens-Johnson Syndrome1CTD_human
HgeneALBC0038356Stomach Neoplasms1CTD_human
HgeneALBC0040034Thrombocytopenia1CTD_human
HgeneALBC0041696Unipolar Depression1CTD_human
HgeneALBC0042109Urticaria1CTD_human
HgeneALBC0042164Uveitis1CTD_human
HgeneALBC0085584Encephalopathies1CTD_human
HgeneALBC0086133Depressive Syndrome1CTD_human
HgeneALBC0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneALBC0234230Pain, Burning1CTD_human
HgeneALBC0234238Ache1CTD_human
HgeneALBC0234254Radiating pain1CTD_human
HgeneALBC0235527Heart Failure, Right-Sided1CTD_human
HgeneALBC0238065Secondary Biliary Cholangitis1CTD_human
HgeneALBC0239981Hypoalbuminemia1CTD_human
HgeneALBC0268742Membranoproliferative Glomerulonephritis, Type I1CTD_human
HgeneALBC0268743Membranoproliferative Glomerulonephritis, Type II1CTD_human
HgeneALBC0273115Lung Injury1CTD_human
HgeneALBC0282126Depression, Neurotic1CTD_human
HgeneALBC0458257Pain, Splitting1CTD_human
HgeneALBC0458259Pain, Crushing1CTD_human
HgeneALBC0751407Pain, Migratory1CTD_human
HgeneALBC0751408Suffering, Physical1CTD_human
HgeneALBC0917798Cerebral Ischemia1CTD_human
HgeneALBC0971858Arthritis, Collagen-Induced1CTD_human
HgeneALBC0993582Arthritis, Experimental1CTD_human
HgeneALBC1274933Drug-Induced Stevens Johnson Syndrome1CTD_human
HgeneALBC1306571Hepatic Insufficiency1CTD_human
HgeneALBC1527304Allergic Reaction1CTD_human
HgeneALBC1623038Cirrhosis1CTD_human
HgeneALBC1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneALBC1720821Membranoproliferative Glomerulonephritis, Type III1CTD_human
HgeneALBC1959583Myocardial Failure1CTD_human
HgeneALBC1961112Heart Decompensation1CTD_human
HgeneALBC2350344Chronic Lung Injury1CTD_human
HgeneALBC3658301Mycoplasma-Induced Stevens-Johnson Syndrome1CTD_human
HgeneALBC3658302Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum1CTD_human
HgeneALBC4505456HIV Coinfection1CTD_human
HgeneALBC4551595Biliary Cirrhosis, Primary, 11CTD_human
HgeneALBC4553297Cystic Echinocccosis1CTD_human
TgeneC2717906Hereditary Angioedema Type I19CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0019243Angioedemas, Hereditary7CTD_human;GENOMICS_ENGLAND
TgeneC1862892Hereditary Angioedema Type II4CTD_human;ORPHANET
TgeneC2717905Hereditary Angioedema Types I and II3CTD_human
TgeneC2931758Acquired angioedema2CTD_human
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0021400Influenza1CTD_human
TgeneC0023890Liver Cirrhosis1CTD_human
TgeneC0024121Lung Neoplasms1CTD_human
TgeneC0024143Lupus Nephritis1CTD_human
TgeneC0239946Fibrosis, Liver1CTD_human
TgeneC0242379Malignant neoplasm of lung1CTD_human
TgeneC0272242Complement deficiency disease1GENOMICS_ENGLAND
TgeneC0398775Hereditary C1 esterase inhibitor deficiency - deficient factor1ORPHANET
TgeneC0398776Hereditary C1 esterase inhibitor deficiency - dysfunctional factor1ORPHANET
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC1852700Complement Component 4, Partial Deficiency Of1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human