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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAAH-FAAH (FusionGDB2 ID:HG2166TG2166)

Fusion Gene Summary for FAAH-FAAH

check button Fusion gene summary
Fusion gene informationFusion gene name: FAAH-FAAH
Fusion gene ID: hg2166tg2166
HgeneTgene
Gene symbol

FAAH

FAAH

Gene ID

2166

2166

Gene namefatty acid amide hydrolasefatty acid amide hydrolase
SynonymsFAAH-1|PSABFAAH-1|PSAB
Cytomap('FAAH')('FAAH')

1p33

1p33

Type of geneprotein-codingprotein-coding
Descriptionfatty-acid amide hydrolase 1anandamide amidohydrolase 1oleamide hydrolase 1fatty-acid amide hydrolase 1anandamide amidohydrolase 1oleamide hydrolase 1
Modification date2020031520200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000243167, ENST00000493735, 
ENST00000243167, ENST00000493735, 
Fusion gene scores* DoF score3 X 4 X 2=244 X 6 X 3=72
# samples 46
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAAH [Title/Abstract] AND FAAH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAAH(46878908)-FAAH(46878954), # samples:1
FAAH(46879292)-FAAH(46879145), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFAAH

GO:0009062

fatty acid catabolic process

9122178

TgeneFAAH

GO:0009062

fatty acid catabolic process

9122178



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for FAAH-FAAH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FAAH-FAAH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for FAAH-FAAH


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:46878908/:46878954)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FAAH-FAAH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FAAH-FAAH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAAH-FAAH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAAH-FAAH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFAAHC0024809Marijuana Abuse3PSYGENET
HgeneFAAHC0013146Drug abuse2CTD_human
HgeneFAAHC0013170Drug habituation2CTD_human
HgeneFAAHC0013222Drug Use Disorders2CTD_human
HgeneFAAHC0028754Obesity2CTD_human
HgeneFAAHC0029231Organic Mental Disorders, Substance-Induced2CTD_human
HgeneFAAHC0038580Substance Dependence2CTD_human
HgeneFAAHC0038586Substance Use Disorders2CTD_human
HgeneFAAHC0038587Substance Withdrawal Syndrome2CTD_human
HgeneFAAHC0086189Drug Withdrawal Symptoms2CTD_human
HgeneFAAHC0087169Withdrawal Symptoms2CTD_human
HgeneFAAHC0236969Substance-Related Disorders2CTD_human
HgeneFAAHC0740858Substance abuse problem2CTD_human
HgeneFAAHC1510472Drug Dependence2CTD_human
HgeneFAAHC4316881Prescription Drug Abuse2CTD_human
HgeneFAAHC0006870Cannabis Dependence1PSYGENET
HgeneFAAHC0020179Huntington Disease1CTD_human
HgeneFAAHC0022333Jacksonian Seizure1CTD_human
HgeneFAAHC0032962Pregnancy Complications1CTD_human
HgeneFAAHC0036572Seizures1CTD_human
HgeneFAAHC0149958Complex partial seizures1CTD_human
HgeneFAAHC0234533Generalized seizures1CTD_human
HgeneFAAHC0234535Clonic Seizures1CTD_human
HgeneFAAHC0270824Visual seizure1CTD_human
HgeneFAAHC0270844Tonic Seizures1CTD_human
HgeneFAAHC0270846Epileptic drop attack1CTD_human
HgeneFAAHC0393574Huntington Disease, Late Onset1CTD_human
HgeneFAAHC0422850Seizures, Somatosensory1CTD_human
HgeneFAAHC0422852Seizures, Auditory1CTD_human
HgeneFAAHC0422853Olfactory seizure1CTD_human
HgeneFAAHC0422854Gustatory seizure1CTD_human
HgeneFAAHC0422855Vertiginous seizure1CTD_human
HgeneFAAHC0494475Tonic - clonic seizures1CTD_human
HgeneFAAHC0751056Non-epileptic convulsion1CTD_human
HgeneFAAHC0751110Single Seizure1CTD_human
HgeneFAAHC0751123Atonic Absence Seizures1CTD_human
HgeneFAAHC0751207Akinetic-Rigid Variant of Huntington Disease1CTD_human
HgeneFAAHC0751208Juvenile Huntington Disease1CTD_human
HgeneFAAHC0751494Convulsive Seizures1CTD_human
HgeneFAAHC0751495Seizures, Focal1CTD_human
HgeneFAAHC0751496Seizures, Sensory1CTD_human
HgeneFAAHC3495874Nonepileptic Seizures1CTD_human
HgeneFAAHC4048158Convulsions1CTD_human
HgeneFAAHC4316903Absence Seizures1CTD_human
HgeneFAAHC4317109Epileptic Seizures1CTD_human
HgeneFAAHC4317123Myoclonic Seizures1CTD_human
HgeneFAAHC4505436Generalized Absence Seizures1CTD_human
TgeneC0024809Marijuana Abuse3PSYGENET
TgeneC0013146Drug abuse2CTD_human
TgeneC0013170Drug habituation2CTD_human
TgeneC0013222Drug Use Disorders2CTD_human
TgeneC0028754Obesity2CTD_human
TgeneC0029231Organic Mental Disorders, Substance-Induced2CTD_human
TgeneC0038580Substance Dependence2CTD_human
TgeneC0038586Substance Use Disorders2CTD_human
TgeneC0038587Substance Withdrawal Syndrome2CTD_human
TgeneC0086189Drug Withdrawal Symptoms2CTD_human
TgeneC0087169Withdrawal Symptoms2CTD_human
TgeneC0236969Substance-Related Disorders2CTD_human
TgeneC0740858Substance abuse problem2CTD_human
TgeneC1510472Drug Dependence2CTD_human
TgeneC4316881Prescription Drug Abuse2CTD_human
TgeneC0006870Cannabis Dependence1PSYGENET
TgeneC0020179Huntington Disease1CTD_human
TgeneC0022333Jacksonian Seizure1CTD_human
TgeneC0032962Pregnancy Complications1CTD_human
TgeneC0036572Seizures1CTD_human
TgeneC0149958Complex partial seizures1CTD_human
TgeneC0234533Generalized seizures1CTD_human
TgeneC0234535Clonic Seizures1CTD_human
TgeneC0270824Visual seizure1CTD_human
TgeneC0270844Tonic Seizures1CTD_human
TgeneC0270846Epileptic drop attack1CTD_human
TgeneC0393574Huntington Disease, Late Onset1CTD_human
TgeneC0422850Seizures, Somatosensory1CTD_human
TgeneC0422852Seizures, Auditory1CTD_human
TgeneC0422853Olfactory seizure1CTD_human
TgeneC0422854Gustatory seizure1CTD_human
TgeneC0422855Vertiginous seizure1CTD_human
TgeneC0494475Tonic - clonic seizures1CTD_human
TgeneC0751056Non-epileptic convulsion1CTD_human
TgeneC0751110Single Seizure1CTD_human
TgeneC0751123Atonic Absence Seizures1CTD_human
TgeneC0751207Akinetic-Rigid Variant of Huntington Disease1CTD_human
TgeneC0751208Juvenile Huntington Disease1CTD_human
TgeneC0751494Convulsive Seizures1CTD_human
TgeneC0751495Seizures, Focal1CTD_human
TgeneC0751496Seizures, Sensory1CTD_human
TgeneC3495874Nonepileptic Seizures1CTD_human
TgeneC4048158Convulsions1CTD_human
TgeneC4316903Absence Seizures1CTD_human
TgeneC4317109Epileptic Seizures1CTD_human
TgeneC4317123Myoclonic Seizures1CTD_human
TgeneC4505436Generalized Absence Seizures1CTD_human