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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FANCA-CYP20A1 (FusionGDB2 ID:HG2175TG57404)

Fusion Gene Summary for FANCA-CYP20A1

check button Fusion gene summary
Fusion gene informationFusion gene name: FANCA-CYP20A1
Fusion gene ID: hg2175tg57404
HgeneTgene
Gene symbol

FANCA

CYP20A1

Gene ID

2175

57404

Gene nameFA complementation group Acytochrome P450 family 20 subfamily A member 1
SynonymsFA|FA-H|FA1|FAA|FACA|FAH|FANCHCYP-M
Cytomap('FANCA')('CYP20A1')

16q24.3

2q33.2

Type of geneprotein-codingprotein-coding
DescriptionFanconi anemia group A proteinFanconi anemia complementation group AFanconi anemia, complementation group HFanconi anemia, type 1cytochrome P450 20A1cytochrome P450 monooxygenasecytochrome P450, family 20, subfamily A, polypeptide 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000389301, ENST00000389302, 
ENST00000534992, ENST00000543736, 
ENST00000563673, ENST00000568369, 
ENST00000567284, 
Fusion gene scores* DoF score13 X 12 X 5=7808 X 11 X 5=440
# samples 139
** MAII scorelog2(13/780*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/440*10)=-2.28950661719499
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FANCA [Title/Abstract] AND CYP20A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFANCA(89880927)-CYP20A1(204143295), # samples:1
Anticipated loss of major functional domain due to fusion event.FANCA-CYP20A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FANCA-CYP20A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FANCA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CYP20A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-R5-A7ZFFANCAchr16

89880927

-CYP20A1chr2

204143295

+


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Fusion Gene ORF analysis for FANCA-CYP20A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000389301ENST00000429815FANCAchr16

89880927

-CYP20A1chr2

204143295

+
5CDS-3UTRENST00000389301ENST00000461371FANCAchr16

89880927

-CYP20A1chr2

204143295

+
5CDS-3UTRENST00000389302ENST00000429815FANCAchr16

89880927

-CYP20A1chr2

204143295

+
5CDS-3UTRENST00000389302ENST00000461371FANCAchr16

89880927

-CYP20A1chr2

204143295

+
5CDS-3UTRENST00000534992ENST00000429815FANCAchr16

89880927

-CYP20A1chr2

204143295

+
5CDS-3UTRENST00000534992ENST00000461371FANCAchr16

89880927

-CYP20A1chr2

204143295

+
5CDS-3UTRENST00000543736ENST00000429815FANCAchr16

89880927

-CYP20A1chr2

204143295

+
5CDS-3UTRENST00000543736ENST00000461371FANCAchr16

89880927

-CYP20A1chr2

204143295

+
5CDS-3UTRENST00000563673ENST00000429815FANCAchr16

89880927

-CYP20A1chr2

204143295

+
5CDS-3UTRENST00000563673ENST00000461371FANCAchr16

89880927

-CYP20A1chr2

204143295

+
5CDS-3UTRENST00000568369ENST00000429815FANCAchr16

89880927

-CYP20A1chr2

204143295

+
5CDS-3UTRENST00000568369ENST00000461371FANCAchr16

89880927

-CYP20A1chr2

204143295

+
In-frameENST00000389301ENST00000356079FANCAchr16

89880927

-CYP20A1chr2

204143295

+
In-frameENST00000389302ENST00000356079FANCAchr16

89880927

-CYP20A1chr2

204143295

+
In-frameENST00000534992ENST00000356079FANCAchr16

89880927

-CYP20A1chr2

204143295

+
In-frameENST00000543736ENST00000356079FANCAchr16

89880927

-CYP20A1chr2

204143295

+
In-frameENST00000563673ENST00000356079FANCAchr16

89880927

-CYP20A1chr2

204143295

+
In-frameENST00000568369ENST00000356079FANCAchr16

89880927

-CYP20A1chr2

204143295

+
intron-3CDSENST00000567284ENST00000356079FANCAchr16

89880927

-CYP20A1chr2

204143295

+
intron-3UTRENST00000567284ENST00000429815FANCAchr16

89880927

-CYP20A1chr2

204143295

+
intron-3UTRENST00000567284ENST00000461371FANCAchr16

89880927

-CYP20A1chr2

204143295

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000389301FANCAchr1689880927-ENST00000356079CYP20A1chr2204143295+1461314311023330
ENST00000568369FANCAchr1689880927-ENST00000356079CYP20A1chr2204143295+1461314311023330
ENST00000389302FANCAchr1689880927-ENST00000356079CYP20A1chr2204143295+1472325421034330
ENST00000563673FANCAchr1689880927-ENST00000356079CYP20A1chr2204143295+1450303201012330
ENST00000534992FANCAchr1689880927-ENST00000356079CYP20A1chr2204143295+1470323401032330
ENST00000543736FANCAchr1689880927-ENST00000356079CYP20A1chr2204143295+1472325421034330

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000389301ENST00000356079FANCAchr1689880927-CYP20A1chr2204143295+0.000176430.99982363
ENST00000568369ENST00000356079FANCAchr1689880927-CYP20A1chr2204143295+0.000176430.99982363
ENST00000389302ENST00000356079FANCAchr1689880927-CYP20A1chr2204143295+0.0001758750.9998241
ENST00000563673ENST00000356079FANCAchr1689880927-CYP20A1chr2204143295+0.0001739690.999826
ENST00000534992ENST00000356079FANCAchr1689880927-CYP20A1chr2204143295+0.0001791910.9998209
ENST00000543736ENST00000356079FANCAchr1689880927-CYP20A1chr2204143295+0.0001758750.9998241

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Fusion Genomic Features for FANCA-CYP20A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FANCAchr1689880927-CYP20A1chr2204143295+1.40E-060.99999857
FANCAchr1689880927-CYP20A1chr2204143295+1.40E-060.99999857

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FANCA-CYP20A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:89880927/chr2:204143295)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFANCAchr16:89880927chr2:204143295ENST00000389301-34318_34941456.0MotifNuclear localization signal
HgeneFANCAchr16:89880927chr2:204143295ENST00000389302-31118_3494298.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCYP20A1chr16:89880927chr2:204143295ENST000003560795134_24226463.0TransmembraneHelical


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Fusion Gene Sequence for FANCA-CYP20A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29303_29303_1_FANCA-CYP20A1_FANCA_chr16_89880927_ENST00000389301_CYP20A1_chr2_204143295_ENST00000356079_length(transcript)=1461nt_BP=314nt
AGCCGCCGCCGGGGCTGTAGGCGCCAAGGCCATGTCCGACTCGTGGGTCCCGAACTCCGCCTCGGGCCAGGACCCAGGGGGCCGCCGGAG
GGCCTGGGCCGAGCTGCTGGCGGGAAGGGTCAAGAGGGAAAAATATAATCCTGAAAGGGCACAGAAATTAAAGGAATCAGCTGTGCGCCT
CCTGCGAAGCCATCAGGACCTGAATGCCCTTTTGCTTGAGGTAGAAGGTCCACTGTGTAAAAAATTGTCTCTCAGCAAAGTGATTGACTG
TGACAGTTCTGAGGCCTATGCTAATCATTCTAGTTCATTTATAGCCCTCATGCAACTGGAGTCTGTTTTAAGGAACATCATAAAAGAACG
AAAAGGAAGGAACTTCAGTCAACATATTTTCATTGACTCCTTAGTACAAGGGAACCTTAATGACCAACAGATCCTAGAAGACAGTATGAT
ATTTTCTCTGGCCAGTTGCATAATAACTGCAAAATTGTGTACCTGGGCAATCTGTTTTTTAACCACCTCTGAAGAAGTTCAAAAAAAATT
ATATGAAGAGATAAACCAAGTTTTTGGAAATGGTCCTGTTACTCCAGAGAAAATTGAGCAGCTCAGATATTGTCAGCATGTGCTTTGTGA
AACTGTTCGAACTGCCAAACTGACTCCAGTTTCTGCCCAGCTTCAAGATATTGAAGGAAAAATTGACCGATTTATTATTCCTAGAGAGAC
CCTCGTCCTTTATGCCCTTGGTGTGGTACTTCAGGATCCTAATACTTGGCCATCTCCACACAAGTTTGATCCAGATCGGTTTGATGATGA
ATTAGTAATGAAAACTTTTTCCTCACTTGGATTCTCAGGCACACAGGAGTGTCCAGAGTTGAGGTTTGCATATATGGTGACCACAGTACT
TCTTAGTGTATTGGTGAAGAGACTGCACCTACTTTCTGTGGAGGGACAGGTTATTGAAACAAAGTATGAACTGGTAACATCATCAAGGGA
AGAAGCTTGGATCACTGTCTCAAAGAGATATTAAAATTTTATACATTTAAAATCATTGTTAAATTGATTGAGGAAAACAACCATTTAAAA
AAAATCTATGTTGAATCCTTTTATAAACCAGTATCACTTTGTAATATAAACACCTATTTGTACTTAATTTTGTAAATTTGGATTTTTATA
TATCATATTTTCTTAATTCATTGTACACATTTGACTTACTGCACAGTATATTGATCATTTTAATGGGAAACTTTAGCTTTCTACTTTTTA
TTTTTGTTTTTTCACTTTCTATGCCATTATTTTTGTATTCTTTTTCTTAGTGTGAGCTCTAAAATCAATGTTCTTGAAAAAGAAATTATT
TTGCAGAAGTTGGGGAATCATGTTTGTTGAATATGTATAAAATAGAAACATAGGCTGGGCGCGGTGGCTCACACCTGTAATCCCTACACT

>29303_29303_1_FANCA-CYP20A1_FANCA_chr16_89880927_ENST00000389301_CYP20A1_chr2_204143295_ENST00000356079_length(amino acids)=330AA_BP=94
MSDSWVPNSASGQDPGGRRRAWAELLAGRVKREKYNPERAQKLKESAVRLLRSHQDLNALLLEVEGPLCKKLSLSKVIDCDSSEAYANHS
SSFIALMQLESVLRNIIKERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGN
GPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLG

--------------------------------------------------------------
>29303_29303_2_FANCA-CYP20A1_FANCA_chr16_89880927_ENST00000389302_CYP20A1_chr2_204143295_ENST00000356079_length(transcript)=1472nt_BP=325nt
CGGGCGCAGGGAGCCGCCGCCGGGGCTGTAGGCGCCAAGGCCATGTCCGACTCGTGGGTCCCGAACTCCGCCTCGGGCCAGGACCCAGGG
GGCCGCCGGAGGGCCTGGGCCGAGCTGCTGGCGGGAAGGGTCAAGAGGGAAAAATATAATCCTGAAAGGGCACAGAAATTAAAGGAATCA
GCTGTGCGCCTCCTGCGAAGCCATCAGGACCTGAATGCCCTTTTGCTTGAGGTAGAAGGTCCACTGTGTAAAAAATTGTCTCTCAGCAAA
GTGATTGACTGTGACAGTTCTGAGGCCTATGCTAATCATTCTAGTTCATTTATAGCCCTCATGCAACTGGAGTCTGTTTTAAGGAACATC
ATAAAAGAACGAAAAGGAAGGAACTTCAGTCAACATATTTTCATTGACTCCTTAGTACAAGGGAACCTTAATGACCAACAGATCCTAGAA
GACAGTATGATATTTTCTCTGGCCAGTTGCATAATAACTGCAAAATTGTGTACCTGGGCAATCTGTTTTTTAACCACCTCTGAAGAAGTT
CAAAAAAAATTATATGAAGAGATAAACCAAGTTTTTGGAAATGGTCCTGTTACTCCAGAGAAAATTGAGCAGCTCAGATATTGTCAGCAT
GTGCTTTGTGAAACTGTTCGAACTGCCAAACTGACTCCAGTTTCTGCCCAGCTTCAAGATATTGAAGGAAAAATTGACCGATTTATTATT
CCTAGAGAGACCCTCGTCCTTTATGCCCTTGGTGTGGTACTTCAGGATCCTAATACTTGGCCATCTCCACACAAGTTTGATCCAGATCGG
TTTGATGATGAATTAGTAATGAAAACTTTTTCCTCACTTGGATTCTCAGGCACACAGGAGTGTCCAGAGTTGAGGTTTGCATATATGGTG
ACCACAGTACTTCTTAGTGTATTGGTGAAGAGACTGCACCTACTTTCTGTGGAGGGACAGGTTATTGAAACAAAGTATGAACTGGTAACA
TCATCAAGGGAAGAAGCTTGGATCACTGTCTCAAAGAGATATTAAAATTTTATACATTTAAAATCATTGTTAAATTGATTGAGGAAAACA
ACCATTTAAAAAAAATCTATGTTGAATCCTTTTATAAACCAGTATCACTTTGTAATATAAACACCTATTTGTACTTAATTTTGTAAATTT
GGATTTTTATATATCATATTTTCTTAATTCATTGTACACATTTGACTTACTGCACAGTATATTGATCATTTTAATGGGAAACTTTAGCTT
TCTACTTTTTATTTTTGTTTTTTCACTTTCTATGCCATTATTTTTGTATTCTTTTTCTTAGTGTGAGCTCTAAAATCAATGTTCTTGAAA
AAGAAATTATTTTGCAGAAGTTGGGGAATCATGTTTGTTGAATATGTATAAAATAGAAACATAGGCTGGGCGCGGTGGCTCACACCTGTA

>29303_29303_2_FANCA-CYP20A1_FANCA_chr16_89880927_ENST00000389302_CYP20A1_chr2_204143295_ENST00000356079_length(amino acids)=330AA_BP=94
MSDSWVPNSASGQDPGGRRRAWAELLAGRVKREKYNPERAQKLKESAVRLLRSHQDLNALLLEVEGPLCKKLSLSKVIDCDSSEAYANHS
SSFIALMQLESVLRNIIKERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGN
GPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLG

--------------------------------------------------------------
>29303_29303_3_FANCA-CYP20A1_FANCA_chr16_89880927_ENST00000534992_CYP20A1_chr2_204143295_ENST00000356079_length(transcript)=1470nt_BP=323nt
GGCGCAGGGAGCCGCCGCCGGGGCTGTAGGCGCCAAGGCCATGTCCGACTCGTGGGTCCCGAACTCCGCCTCGGGCCAGGACCCAGGGGG
CCGCCGGAGGGCCTGGGCCGAGCTGCTGGCGGGAAGGGTCAAGAGGGAAAAATATAATCCTGAAAGGGCACAGAAATTAAAGGAATCAGC
TGTGCGCCTCCTGCGAAGCCATCAGGACCTGAATGCCCTTTTGCTTGAGGTAGAAGGTCCACTGTGTAAAAAATTGTCTCTCAGCAAAGT
GATTGACTGTGACAGTTCTGAGGCCTATGCTAATCATTCTAGTTCATTTATAGCCCTCATGCAACTGGAGTCTGTTTTAAGGAACATCAT
AAAAGAACGAAAAGGAAGGAACTTCAGTCAACATATTTTCATTGACTCCTTAGTACAAGGGAACCTTAATGACCAACAGATCCTAGAAGA
CAGTATGATATTTTCTCTGGCCAGTTGCATAATAACTGCAAAATTGTGTACCTGGGCAATCTGTTTTTTAACCACCTCTGAAGAAGTTCA
AAAAAAATTATATGAAGAGATAAACCAAGTTTTTGGAAATGGTCCTGTTACTCCAGAGAAAATTGAGCAGCTCAGATATTGTCAGCATGT
GCTTTGTGAAACTGTTCGAACTGCCAAACTGACTCCAGTTTCTGCCCAGCTTCAAGATATTGAAGGAAAAATTGACCGATTTATTATTCC
TAGAGAGACCCTCGTCCTTTATGCCCTTGGTGTGGTACTTCAGGATCCTAATACTTGGCCATCTCCACACAAGTTTGATCCAGATCGGTT
TGATGATGAATTAGTAATGAAAACTTTTTCCTCACTTGGATTCTCAGGCACACAGGAGTGTCCAGAGTTGAGGTTTGCATATATGGTGAC
CACAGTACTTCTTAGTGTATTGGTGAAGAGACTGCACCTACTTTCTGTGGAGGGACAGGTTATTGAAACAAAGTATGAACTGGTAACATC
ATCAAGGGAAGAAGCTTGGATCACTGTCTCAAAGAGATATTAAAATTTTATACATTTAAAATCATTGTTAAATTGATTGAGGAAAACAAC
CATTTAAAAAAAATCTATGTTGAATCCTTTTATAAACCAGTATCACTTTGTAATATAAACACCTATTTGTACTTAATTTTGTAAATTTGG
ATTTTTATATATCATATTTTCTTAATTCATTGTACACATTTGACTTACTGCACAGTATATTGATCATTTTAATGGGAAACTTTAGCTTTC
TACTTTTTATTTTTGTTTTTTCACTTTCTATGCCATTATTTTTGTATTCTTTTTCTTAGTGTGAGCTCTAAAATCAATGTTCTTGAAAAA
GAAATTATTTTGCAGAAGTTGGGGAATCATGTTTGTTGAATATGTATAAAATAGAAACATAGGCTGGGCGCGGTGGCTCACACCTGTAAT

>29303_29303_3_FANCA-CYP20A1_FANCA_chr16_89880927_ENST00000534992_CYP20A1_chr2_204143295_ENST00000356079_length(amino acids)=330AA_BP=94
MSDSWVPNSASGQDPGGRRRAWAELLAGRVKREKYNPERAQKLKESAVRLLRSHQDLNALLLEVEGPLCKKLSLSKVIDCDSSEAYANHS
SSFIALMQLESVLRNIIKERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGN
GPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLG

--------------------------------------------------------------
>29303_29303_4_FANCA-CYP20A1_FANCA_chr16_89880927_ENST00000543736_CYP20A1_chr2_204143295_ENST00000356079_length(transcript)=1472nt_BP=325nt
CGGGCGCAGGGAGCCGCCGCCGGGGCTGTAGGCGCCAAGGCCATGTCCGACTCGTGGGTCCCGAACTCCGCCTCGGGCCAGGACCCAGGG
GGCCGCCGGAGGGCCTGGGCCGAGCTGCTGGCGGGAAGGGTCAAGAGGGAAAAATATAATCCTGAAAGGGCACAGAAATTAAAGGAATCA
GCTGTGCGCCTCCTGCGAAGCCATCAGGACCTGAATGCCCTTTTGCTTGAGGTAGAAGGTCCACTGTGTAAAAAATTGTCTCTCAGCAAA
GTGATTGACTGTGACAGTTCTGAGGCCTATGCTAATCATTCTAGTTCATTTATAGCCCTCATGCAACTGGAGTCTGTTTTAAGGAACATC
ATAAAAGAACGAAAAGGAAGGAACTTCAGTCAACATATTTTCATTGACTCCTTAGTACAAGGGAACCTTAATGACCAACAGATCCTAGAA
GACAGTATGATATTTTCTCTGGCCAGTTGCATAATAACTGCAAAATTGTGTACCTGGGCAATCTGTTTTTTAACCACCTCTGAAGAAGTT
CAAAAAAAATTATATGAAGAGATAAACCAAGTTTTTGGAAATGGTCCTGTTACTCCAGAGAAAATTGAGCAGCTCAGATATTGTCAGCAT
GTGCTTTGTGAAACTGTTCGAACTGCCAAACTGACTCCAGTTTCTGCCCAGCTTCAAGATATTGAAGGAAAAATTGACCGATTTATTATT
CCTAGAGAGACCCTCGTCCTTTATGCCCTTGGTGTGGTACTTCAGGATCCTAATACTTGGCCATCTCCACACAAGTTTGATCCAGATCGG
TTTGATGATGAATTAGTAATGAAAACTTTTTCCTCACTTGGATTCTCAGGCACACAGGAGTGTCCAGAGTTGAGGTTTGCATATATGGTG
ACCACAGTACTTCTTAGTGTATTGGTGAAGAGACTGCACCTACTTTCTGTGGAGGGACAGGTTATTGAAACAAAGTATGAACTGGTAACA
TCATCAAGGGAAGAAGCTTGGATCACTGTCTCAAAGAGATATTAAAATTTTATACATTTAAAATCATTGTTAAATTGATTGAGGAAAACA
ACCATTTAAAAAAAATCTATGTTGAATCCTTTTATAAACCAGTATCACTTTGTAATATAAACACCTATTTGTACTTAATTTTGTAAATTT
GGATTTTTATATATCATATTTTCTTAATTCATTGTACACATTTGACTTACTGCACAGTATATTGATCATTTTAATGGGAAACTTTAGCTT
TCTACTTTTTATTTTTGTTTTTTCACTTTCTATGCCATTATTTTTGTATTCTTTTTCTTAGTGTGAGCTCTAAAATCAATGTTCTTGAAA
AAGAAATTATTTTGCAGAAGTTGGGGAATCATGTTTGTTGAATATGTATAAAATAGAAACATAGGCTGGGCGCGGTGGCTCACACCTGTA

>29303_29303_4_FANCA-CYP20A1_FANCA_chr16_89880927_ENST00000543736_CYP20A1_chr2_204143295_ENST00000356079_length(amino acids)=330AA_BP=94
MSDSWVPNSASGQDPGGRRRAWAELLAGRVKREKYNPERAQKLKESAVRLLRSHQDLNALLLEVEGPLCKKLSLSKVIDCDSSEAYANHS
SSFIALMQLESVLRNIIKERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGN
GPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLG

--------------------------------------------------------------
>29303_29303_5_FANCA-CYP20A1_FANCA_chr16_89880927_ENST00000563673_CYP20A1_chr2_204143295_ENST00000356079_length(transcript)=1450nt_BP=303nt
GGGCTGTAGGCGCCAAGGCCATGTCCGACTCGTGGGTCCCGAACTCCGCCTCGGGCCAGGACCCAGGGGGCCGCCGGAGGGCCTGGGCCG
AGCTGCTGGCGGGAAGGGTCAAGAGGGAAAAATATAATCCTGAAAGGGCACAGAAATTAAAGGAATCAGCTGTGCGCCTCCTGCGAAGCC
ATCAGGACCTGAATGCCCTTTTGCTTGAGGTAGAAGGTCCACTGTGTAAAAAATTGTCTCTCAGCAAAGTGATTGACTGTGACAGTTCTG
AGGCCTATGCTAATCATTCTAGTTCATTTATAGCCCTCATGCAACTGGAGTCTGTTTTAAGGAACATCATAAAAGAACGAAAAGGAAGGA
ACTTCAGTCAACATATTTTCATTGACTCCTTAGTACAAGGGAACCTTAATGACCAACAGATCCTAGAAGACAGTATGATATTTTCTCTGG
CCAGTTGCATAATAACTGCAAAATTGTGTACCTGGGCAATCTGTTTTTTAACCACCTCTGAAGAAGTTCAAAAAAAATTATATGAAGAGA
TAAACCAAGTTTTTGGAAATGGTCCTGTTACTCCAGAGAAAATTGAGCAGCTCAGATATTGTCAGCATGTGCTTTGTGAAACTGTTCGAA
CTGCCAAACTGACTCCAGTTTCTGCCCAGCTTCAAGATATTGAAGGAAAAATTGACCGATTTATTATTCCTAGAGAGACCCTCGTCCTTT
ATGCCCTTGGTGTGGTACTTCAGGATCCTAATACTTGGCCATCTCCACACAAGTTTGATCCAGATCGGTTTGATGATGAATTAGTAATGA
AAACTTTTTCCTCACTTGGATTCTCAGGCACACAGGAGTGTCCAGAGTTGAGGTTTGCATATATGGTGACCACAGTACTTCTTAGTGTAT
TGGTGAAGAGACTGCACCTACTTTCTGTGGAGGGACAGGTTATTGAAACAAAGTATGAACTGGTAACATCATCAAGGGAAGAAGCTTGGA
TCACTGTCTCAAAGAGATATTAAAATTTTATACATTTAAAATCATTGTTAAATTGATTGAGGAAAACAACCATTTAAAAAAAATCTATGT
TGAATCCTTTTATAAACCAGTATCACTTTGTAATATAAACACCTATTTGTACTTAATTTTGTAAATTTGGATTTTTATATATCATATTTT
CTTAATTCATTGTACACATTTGACTTACTGCACAGTATATTGATCATTTTAATGGGAAACTTTAGCTTTCTACTTTTTATTTTTGTTTTT
TCACTTTCTATGCCATTATTTTTGTATTCTTTTTCTTAGTGTGAGCTCTAAAATCAATGTTCTTGAAAAAGAAATTATTTTGCAGAAGTT
GGGGAATCATGTTTGTTGAATATGTATAAAATAGAAACATAGGCTGGGCGCGGTGGCTCACACCTGTAATCCCTACACTTTGGGAGGCTG

>29303_29303_5_FANCA-CYP20A1_FANCA_chr16_89880927_ENST00000563673_CYP20A1_chr2_204143295_ENST00000356079_length(amino acids)=330AA_BP=94
MSDSWVPNSASGQDPGGRRRAWAELLAGRVKREKYNPERAQKLKESAVRLLRSHQDLNALLLEVEGPLCKKLSLSKVIDCDSSEAYANHS
SSFIALMQLESVLRNIIKERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGN
GPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLG

--------------------------------------------------------------
>29303_29303_6_FANCA-CYP20A1_FANCA_chr16_89880927_ENST00000568369_CYP20A1_chr2_204143295_ENST00000356079_length(transcript)=1461nt_BP=314nt
AGCCGCCGCCGGGGCTGTAGGCGCCAAGGCCATGTCCGACTCGTGGGTCCCGAACTCCGCCTCGGGCCAGGACCCAGGGGGCCGCCGGAG
GGCCTGGGCCGAGCTGCTGGCGGGAAGGGTCAAGAGGGAAAAATATAATCCTGAAAGGGCACAGAAATTAAAGGAATCAGCTGTGCGCCT
CCTGCGAAGCCATCAGGACCTGAATGCCCTTTTGCTTGAGGTAGAAGGTCCACTGTGTAAAAAATTGTCTCTCAGCAAAGTGATTGACTG
TGACAGTTCTGAGGCCTATGCTAATCATTCTAGTTCATTTATAGCCCTCATGCAACTGGAGTCTGTTTTAAGGAACATCATAAAAGAACG
AAAAGGAAGGAACTTCAGTCAACATATTTTCATTGACTCCTTAGTACAAGGGAACCTTAATGACCAACAGATCCTAGAAGACAGTATGAT
ATTTTCTCTGGCCAGTTGCATAATAACTGCAAAATTGTGTACCTGGGCAATCTGTTTTTTAACCACCTCTGAAGAAGTTCAAAAAAAATT
ATATGAAGAGATAAACCAAGTTTTTGGAAATGGTCCTGTTACTCCAGAGAAAATTGAGCAGCTCAGATATTGTCAGCATGTGCTTTGTGA
AACTGTTCGAACTGCCAAACTGACTCCAGTTTCTGCCCAGCTTCAAGATATTGAAGGAAAAATTGACCGATTTATTATTCCTAGAGAGAC
CCTCGTCCTTTATGCCCTTGGTGTGGTACTTCAGGATCCTAATACTTGGCCATCTCCACACAAGTTTGATCCAGATCGGTTTGATGATGA
ATTAGTAATGAAAACTTTTTCCTCACTTGGATTCTCAGGCACACAGGAGTGTCCAGAGTTGAGGTTTGCATATATGGTGACCACAGTACT
TCTTAGTGTATTGGTGAAGAGACTGCACCTACTTTCTGTGGAGGGACAGGTTATTGAAACAAAGTATGAACTGGTAACATCATCAAGGGA
AGAAGCTTGGATCACTGTCTCAAAGAGATATTAAAATTTTATACATTTAAAATCATTGTTAAATTGATTGAGGAAAACAACCATTTAAAA
AAAATCTATGTTGAATCCTTTTATAAACCAGTATCACTTTGTAATATAAACACCTATTTGTACTTAATTTTGTAAATTTGGATTTTTATA
TATCATATTTTCTTAATTCATTGTACACATTTGACTTACTGCACAGTATATTGATCATTTTAATGGGAAACTTTAGCTTTCTACTTTTTA
TTTTTGTTTTTTCACTTTCTATGCCATTATTTTTGTATTCTTTTTCTTAGTGTGAGCTCTAAAATCAATGTTCTTGAAAAAGAAATTATT
TTGCAGAAGTTGGGGAATCATGTTTGTTGAATATGTATAAAATAGAAACATAGGCTGGGCGCGGTGGCTCACACCTGTAATCCCTACACT

>29303_29303_6_FANCA-CYP20A1_FANCA_chr16_89880927_ENST00000568369_CYP20A1_chr2_204143295_ENST00000356079_length(amino acids)=330AA_BP=94
MSDSWVPNSASGQDPGGRRRAWAELLAGRVKREKYNPERAQKLKESAVRLLRSHQDLNALLLEVEGPLCKKLSLSKVIDCDSSEAYANHS
SSFIALMQLESVLRNIIKERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGN
GPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FANCA-CYP20A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FANCA-CYP20A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FANCA-CYP20A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFANCAC3469521FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)19CLINGEN;GENOMICS_ENGLAND;UNIPROT
HgeneFANCAC1856796Estren-Dameshek Variant of Fanconi Anemia6CLINGEN
HgeneFANCAC1856797Estren-Dameshek Variant of Fanconi Pancytopenia6CLINGEN
HgeneFANCAC0015625Fanconi Anemia5CTD_human;GENOMICS_ENGLAND
HgeneFANCAC0030312Pancytopenia2GENOMICS_ENGLAND
HgeneFANCAC1384666hearing impairment2GENOMICS_ENGLAND
HgeneFANCAC1855710Bone marrow hypocellularity2GENOMICS_ENGLAND
HgeneFANCAC2750866Growth retardation, pre- and postnatal2GENOMICS_ENGLAND
HgeneFANCAC0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneFANCAC0005695Bladder Neoplasm1CTD_human
HgeneFANCAC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneFANCAC0020459Hyperinsulinism1CTD_human
HgeneFANCAC0023418leukemia1CGI;GENOMICS_ENGLAND
HgeneFANCAC0023465Acute monocytic leukemia1GENOMICS_ENGLAND
HgeneFANCAC0023467Leukemia, Myelocytic, Acute1CGI;GENOMICS_ENGLAND
HgeneFANCAC0036095Salivary Gland Neoplasms1CTD_human
HgeneFANCAC0220636Malignant neoplasm of salivary gland1CTD_human
HgeneFANCAC0265219Miller Dieker syndrome1GENOMICS_ENGLAND
HgeneFANCAC1257963Endogenous Hyperinsulinism1CTD_human
HgeneFANCAC1257964Exogenous Hyperinsulinism1CTD_human
HgeneFANCAC1257965Compensatory Hyperinsulinemia1CTD_human
HgeneFANCAC3463824MYELODYSPLASTIC SYNDROME1GENOMICS_ENGLAND
HgeneFANCAC4228778Abnormality of radial ray1GENOMICS_ENGLAND