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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ALDH2-CLIC1 (FusionGDB2 ID:HG217TG1192)

Fusion Gene Summary for ALDH2-CLIC1

check button Fusion gene summary
Fusion gene informationFusion gene name: ALDH2-CLIC1
Fusion gene ID: hg217tg1192
HgeneTgene
Gene symbol

ALDH2

CLIC1

Gene ID

217

1192

Gene namealdehyde dehydrogenase 2 family memberchloride intracellular channel 1
SynonymsALDH-E2|ALDHI|ALDMCL1C1|CLCNL1|G6|NCC27
Cytomap('ALDH2')('CLIC1')

12q24.12

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionaldehyde dehydrogenase, mitochondrialALDH class 2acetaldehyde dehydrogenase 2aldehyde dehydrogenase 2 family (mitochondrial)epididymis secretory sperm binding proteinliver mitochondrial ALDHnucleus-encoded mitochondrial aldehyde dehydrogenase 2chloride intracellular channel protein 1RNCC proteinchloride channel ABPhRNCCnuclear chloride ion channel 27nuclear chloride ion channel proteinp64CLCPregulatory nuclear chloride ion channel protein
Modification date2020031320200313
UniProtAcc

P05091

.
Ensembl transtripts involved in fusion geneENST00000261733, ENST00000416293, 
Fusion gene scores* DoF score26 X 20 X 11=57208 X 10 X 4=320
# samples 219
** MAII scorelog2(21/5720*10)=-4.76755391399963
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/320*10)=-1.83007499855769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALDH2 [Title/Abstract] AND CLIC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALDH2(112221082)-CLIC1(31698653), # samples:3
Anticipated loss of major functional domain due to fusion event.ALDH2-CLIC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ALDH2-CLIC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ALDH2-CLIC1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ALDH2-CLIC1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ALDH2-CLIC1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCLIC1

GO:0006821

chloride transport

9139710


check buttonFusion gene breakpoints across ALDH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CLIC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-A03F-01AALDH2chr12

112221082

+CLIC1chr6

31698653

-
ChimerDB4COADTCGA-AZ-4681-01AALDH2chr12

112221082

+CLIC1chr6

31698653

-
ChimerDB4READTCGA-AG-3728ALDH2chr12

112221082

+CLIC1chr6

31698653

-


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Fusion Gene ORF analysis for ALDH2-CLIC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000261733ENST00000383404ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000383405ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000400052ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000400058ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000415179ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000418285ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000420458ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000422167ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000423055ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000423143ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000423804ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000425464ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000431921ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000433916ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000434202ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000435242ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000438708ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000438750ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000442045ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000447338ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000447369ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000451546ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000456863ALDH2chr12

112221082

+CLIC1chr6

31698653

-
5CDS-intronENST00000261733ENST00000457485ALDH2chr12

112221082

+CLIC1chr6

31698653

-
Frame-shiftENST00000261733ENST00000375779ALDH2chr12

112221082

+CLIC1chr6

31698653

-
Frame-shiftENST00000261733ENST00000375784ALDH2chr12

112221082

+CLIC1chr6

31698653

-
In-frameENST00000261733ENST00000375780ALDH2chr12

112221082

+CLIC1chr6

31698653

-
In-frameENST00000261733ENST00000395892ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-3CDSENST00000416293ENST00000375779ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-3CDSENST00000416293ENST00000375780ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-3CDSENST00000416293ENST00000375784ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-3CDSENST00000416293ENST00000395892ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000383404ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000383405ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000400052ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000400058ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000415179ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000418285ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000420458ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000422167ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000423055ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000423143ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000423804ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000425464ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000431921ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000433916ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000434202ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000435242ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000438708ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000438750ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000442045ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000447338ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000447369ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000451546ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000456863ALDH2chr12

112221082

+CLIC1chr6

31698653

-
intron-intronENST00000416293ENST00000457485ALDH2chr12

112221082

+CLIC1chr6

31698653

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261733ALDH2chr12112221082+ENST00000375780CLIC1chr631698653-596300294593100
ENST00000261733ALDH2chr12112221082+ENST00000395892CLIC1chr631698653-596300294593100

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261733ENST00000375780ALDH2chr12112221082+CLIC1chr631698653-0.59376130.4062387
ENST00000261733ENST00000395892ALDH2chr12112221082+CLIC1chr631698653-0.59376130.4062387

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Fusion Genomic Features for ALDH2-CLIC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ALDH2-CLIC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:112221082/chr6:31698653)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALDH2

P05091

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCLIC1chr12:112221082chr6:31698653ENST000003757790793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000003757800793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000003757840693_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000003834040793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000003834050793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000003958920893_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004000520693_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004000580893_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004151790893_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004182850693_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004204580793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004221670693_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004230550793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004231430793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004238040793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004254640693_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004319210793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004339160893_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004342020793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004352420893_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004387080793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004387500793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004420450793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004473380893_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004473690793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004515460893_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004568630693_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004574850693_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST00000375779072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000375780072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000375784062_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000383404072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000383405072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000395892082_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000400052062_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000400058082_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000415179082_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000418285062_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000420458072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000422167062_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000423055072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000423143072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000423804072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000425464062_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000431921072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000433916082_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000434202072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000435242082_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000438708072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000438750072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000442045072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000447338082_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000447369072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000451546082_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000456863062_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000457485062_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000003757790726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000003757800726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000003757840626_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000003834040726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000003834050726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000003958920826_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004000520626_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004000580826_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004151790826_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004182850626_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004204580726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004221670626_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004230550726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004231430726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004238040726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004254640626_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004319210726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004339160826_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004342020726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004352420826_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004387080726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004387500726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004420450726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004473380826_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004473690726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004515460826_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004568630626_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004574850626_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneALDH2chr12:112221082chr6:31698653ENST00000261733+113262_2670518.0Nucleotide bindingNAD
HgeneALDH2chr12:112221082chr6:31698653ENST00000416293+112262_2670471.0Nucleotide bindingNAD


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Fusion Gene Sequence for ALDH2-CLIC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3868_3868_1_ALDH2-CLIC1_ALDH2_chr12_112221082_ENST00000261733_CLIC1_chr6_31698653_ENST00000375780_length(transcript)=596nt_BP=300nt
TCAGTGGCCCTGAGACCCTAGCTCTGCTCTCGGTCCGCTCGCTGTCCGCTAGCCCGCTGCGATGTTGCGCGCTGCCGCCCGCTTCGGGCC
CCGCCTGGGCCGCCGCCTCTTGTCAGCCGCCGCCACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTT
CATAAACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACTGGAGAGGTCATCTGTCAGGTAGCTGA
AGGGGACAAGGGGACCGGACCTACCTGGCGTCGCCTATGAGCAAGTGGCAAAGGCCCTCAAATAAGCCCCTCCTGGGACTCCCTCAACCC
CCTCCATTTTCTCCACAAAGGCCCTGGTGGTTTCCACATTGCTACCCAATGGACACACTCCAAAATGGCCAGTGGGCAGGGAATCCTGGA
GCACTTGTTCCGGGATGGTGTGGTGGAAGAGGGGATGAGGGAAAGAAATGGGGGGCCTGGGTCAGATTTTTATTGTGGGGTGGGATGAGT

>3868_3868_1_ALDH2-CLIC1_ALDH2_chr12_112221082_ENST00000261733_CLIC1_chr6_31698653_ENST00000375780_length(amino acids)=100AA_BP=2
MASPMSKWQRPSNKPLLGLPQPPPFSPQRPWWFPHCYPMDTLQNGQWAGNPGALVPGWCGGRGDEGKKWGAWVRFLLWGGMSRTTYFSNK

--------------------------------------------------------------
>3868_3868_2_ALDH2-CLIC1_ALDH2_chr12_112221082_ENST00000261733_CLIC1_chr6_31698653_ENST00000395892_length(transcript)=596nt_BP=300nt
TCAGTGGCCCTGAGACCCTAGCTCTGCTCTCGGTCCGCTCGCTGTCCGCTAGCCCGCTGCGATGTTGCGCGCTGCCGCCCGCTTCGGGCC
CCGCCTGGGCCGCCGCCTCTTGTCAGCCGCCGCCACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTT
CATAAACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACTGGAGAGGTCATCTGTCAGGTAGCTGA
AGGGGACAAGGGGACCGGACCTACCTGGCGTCGCCTATGAGCAAGTGGCAAAGGCCCTCAAATAAGCCCCTCCTGGGACTCCCTCAACCC
CCTCCATTTTCTCCACAAAGGCCCTGGTGGTTTCCACATTGCTACCCAATGGACACACTCCAAAATGGCCAGTGGGCAGGGAATCCTGGA
GCACTTGTTCCGGGATGGTGTGGTGGAAGAGGGGATGAGGGAAAGAAATGGGGGGCCTGGGTCAGATTTTTATTGTGGGGTGGGATGAGT

>3868_3868_2_ALDH2-CLIC1_ALDH2_chr12_112221082_ENST00000261733_CLIC1_chr6_31698653_ENST00000395892_length(amino acids)=100AA_BP=2
MASPMSKWQRPSNKPLLGLPQPPPFSPQRPWWFPHCYPMDTLQNGQWAGNPGALVPGWCGGRGDEGKKWGAWVRFLLWGGMSRTTYFSNK

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Fusion Gene PPI Analysis for ALDH2-CLIC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ALDH2-CLIC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneALDH2P05091DB00536GuanidineInhibitorSmall moleculeApproved
HgeneALDH2P05091DB00536GuanidineInhibitorSmall moleculeApproved
HgeneALDH2P05091DB00822DisulfiramInhibitorSmall moleculeApproved
HgeneALDH2P05091DB00822DisulfiramInhibitorSmall moleculeApproved
HgeneALDH2P05091DB00157NADHSmall moleculeApproved|Nutraceutical
HgeneALDH2P05091DB00157NADHSmall moleculeApproved|Nutraceutical

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Related Diseases for ALDH2-CLIC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALDH2C0001973Alcoholic Intoxication, Chronic7CTD_human;PSYGENET
HgeneALDH2C0085762Alcohol abuse7CTD_human;PSYGENET
HgeneALDH2C0001969Alcoholic Intoxication5PSYGENET
HgeneALDH2C0393756Hangover from alcohol4PSYGENET
HgeneALDH2C0236664Alcohol-Related Disorders3PSYGENET
HgeneALDH2C0001956Alcohol Use Disorder2CTD_human
HgeneALDH2C0004096Asthma2CTD_human
HgeneALDH2C0005586Bipolar Disorder2PSYGENET
HgeneALDH2C0279626Squamous cell carcinoma of esophagus2CTD_human
HgeneALDH2C0009402Colorectal Carcinoma1CTD_human
HgeneALDH2C0009404Colorectal Neoplasms1CTD_human
HgeneALDH2C0014859Esophageal Neoplasms1CTD_human
HgeneALDH2C0016382Flushing1CTD_human
HgeneALDH2C0016689Freckles1CTD_human
HgeneALDH2C0021364Male infertility1CTD_human
HgeneALDH2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneALDH2C0025209Melanosis1CTD_human
HgeneALDH2C0025218Chloasma1CTD_human
HgeneALDH2C0028796Dermatitis, Occupational1CTD_human
HgeneALDH2C0032927Precancerous Conditions1CTD_human
HgeneALDH2C0042373Vascular Diseases1CTD_human
HgeneALDH2C0086457Industrial Dermatosis1CTD_human
HgeneALDH2C0236970Alcohol-Induced Disorders1CTD_human
HgeneALDH2C0242973Ventricular Dysfunction1CTD_human
HgeneALDH2C0282313Condition, Preneoplastic1CTD_human
HgeneALDH2C0342257Complications of Diabetes Mellitus1CTD_human
HgeneALDH2C0349464Wernicke-Korsakoff Syndrome1PSYGENET
HgeneALDH2C0400966Non-alcoholic Fatty Liver Disease1CTD_human
HgeneALDH2C0520459Necrotizing Enterocolitis1CTD_human
HgeneALDH2C0546837Malignant neoplasm of esophagus1CTD_human
HgeneALDH2C0848676Subfertility, Male1CTD_human
HgeneALDH2C0917731Male sterility1CTD_human
HgeneALDH2C2674838ALCOHOL SENSITIVITY, ACUTE1CTD_human
HgeneALDH2C3241937Nonalcoholic Steatohepatitis1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0019693HIV Infections1CTD_human
TgeneC0022548Keloid1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0027627Neoplasm Metastasis1CTD_human
TgeneC0029408Degenerative polyarthritis1CTD_human
TgeneC0086743Osteoarthrosis Deformans1CTD_human
TgeneC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC4505456HIV Coinfection1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human