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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ALDH2-HSPA1A (FusionGDB2 ID:HG217TG3303)

Fusion Gene Summary for ALDH2-HSPA1A

check button Fusion gene summary
Fusion gene informationFusion gene name: ALDH2-HSPA1A
Fusion gene ID: hg217tg3303
HgeneTgene
Gene symbol

ALDH2

HSPA1A

Gene ID

217

3303

Gene namealdehyde dehydrogenase 2 family memberheat shock protein family A (Hsp70) member 1A
SynonymsALDH-E2|ALDHI|ALDMHEL-S-103|HSP70-1|HSP70-1A|HSP70-2|HSP70.1|HSP70.2|HSP70I|HSP72|HSPA1
Cytomap('ALDH2')('HSPA1A')

12q24.12

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionaldehyde dehydrogenase, mitochondrialALDH class 2acetaldehyde dehydrogenase 2aldehyde dehydrogenase 2 family (mitochondrial)epididymis secretory sperm binding proteinliver mitochondrial ALDHnucleus-encoded mitochondrial aldehyde dehydrogenase 2heat shock 70 kDa protein 1AHSP70-1/HSP70-2HSP70.1/HSP70.2Heat shock 70 kDa protein 1BHeat shock 70 kDa protein 2dnaK-type molecular chaperone HSP70-1epididymis secretory protein Li 103epididymis secretory sperm binding proteinheat shock 70 kDa pr
Modification date2020031320200327
UniProtAcc

P05091

.
Ensembl transtripts involved in fusion geneENST00000261733, ENST00000416293, 
Fusion gene scores* DoF score26 X 20 X 11=57206 X 15 X 4=360
# samples 2111
** MAII scorelog2(21/5720*10)=-4.76755391399963
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALDH2 [Title/Abstract] AND HSPA1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALDH2(112221083)-HSPA1A(31785084), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHSPA1A

GO:0006402

mRNA catabolic process

10205060

TgeneHSPA1A

GO:0006986

response to unfolded protein

10859165

TgeneHSPA1A

GO:0031396

regulation of protein ubiquitination

16809764

TgeneHSPA1A

GO:0031397

negative regulation of protein ubiquitination

12150907

TgeneHSPA1A

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

24613385

TgeneHSPA1A

GO:0033120

positive regulation of RNA splicing

20625543

TgeneHSPA1A

GO:0034605

cellular response to heat

24061851

TgeneHSPA1A

GO:0042026

protein refolding

15603737|21231916

TgeneHSPA1A

GO:0046034

ATP metabolic process

23921388

TgeneHSPA1A

GO:0050821

protein stabilization

21909508

TgeneHSPA1A

GO:0051131

chaperone-mediated protein complex assembly

10811660

TgeneHSPA1A

GO:0090084

negative regulation of inclusion body assembly

15603737|21231916

TgeneHSPA1A

GO:0097201

negative regulation of transcription from RNA polymerase II promoter in response to stress

9499401

TgeneHSPA1A

GO:1901029

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

20625543

TgeneHSPA1A

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

12150907|20625543

TgeneHSPA1A

GO:1902380

positive regulation of endoribonuclease activity

20625543


check buttonFusion gene breakpoints across ALDH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across HSPA1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-3510-01AALDH2chr12

112221083

+HSPA1Achr6

31785084

+
ChimerDB4UCECTCGA-B5-A11S-01AALDH2chr12

112221083

+HSPA1Achr6

31785084

+


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Fusion Gene ORF analysis for ALDH2-HSPA1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000261733ENST00000383389ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
5CDS-intronENST00000261733ENST00000400040ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
5CDS-intronENST00000261733ENST00000422919ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
5CDS-intronENST00000261733ENST00000430065ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
5CDS-intronENST00000261733ENST00000433487ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
5CDS-intronENST00000261733ENST00000441618ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
5CDS-intronENST00000261733ENST00000449876ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
5CDS-intronENST00000261733ENST00000452298ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
In-frameENST00000261733ENST00000375651ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
In-frameENST00000261733ENST00000458062ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
In-frameENST00000261733ENST00000608703ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
intron-3CDSENST00000416293ENST00000375651ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
intron-3CDSENST00000416293ENST00000458062ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
intron-3CDSENST00000416293ENST00000608703ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
intron-intronENST00000416293ENST00000383389ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
intron-intronENST00000416293ENST00000400040ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
intron-intronENST00000416293ENST00000422919ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
intron-intronENST00000416293ENST00000430065ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
intron-intronENST00000416293ENST00000433487ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
intron-intronENST00000416293ENST00000441618ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
intron-intronENST00000416293ENST00000449876ALDH2chr12

112221083

+HSPA1Achr6

31785084

+
intron-intronENST00000416293ENST00000452298ALDH2chr12

112221083

+HSPA1Achr6

31785084

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261733ALDH2chr12112221083+ENST00000375651HSPA1Achr631785084+932299266673135
ENST00000261733ALDH2chr12112221083+ENST00000458062HSPA1Achr631785084+674299266673136
ENST00000261733ALDH2chr12112221083+ENST00000608703HSPA1Achr631785084+938299266673135

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261733ENST00000375651ALDH2chr12112221083+HSPA1Achr631785084+0.0078776860.99212223
ENST00000261733ENST00000458062ALDH2chr12112221083+HSPA1Achr631785084+0.0074140420.99258596
ENST00000261733ENST00000608703ALDH2chr12112221083+HSPA1Achr631785084+0.0080968710.9919031

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Fusion Genomic Features for ALDH2-HSPA1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ALDH2-HSPA1A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:112221083/chr6:31785084)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALDH2

P05091

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneALDH2chr12:112221083chr6:31785084ENST00000261733+113262_2670518.0Nucleotide bindingNAD
HgeneALDH2chr12:112221083chr6:31785084ENST00000416293+112262_2670471.0Nucleotide bindingNAD


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Fusion Gene Sequence for ALDH2-HSPA1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3874_3874_1_ALDH2-HSPA1A_ALDH2_chr12_112221083_ENST00000261733_HSPA1A_chr6_31785084_ENST00000375651_length(transcript)=932nt_BP=299nt
TCAGTGGCCCTGAGACCCTAGCTCTGCTCTCGGTCCGCTCGCTGTCCGCTAGCCCGCTGCGATGTTGCGCGCTGCCGCCCGCTTCGGGCC
CCGCCTGGGCCGCCGCCTCTTGTCAGCCGCCGCCACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTT
CATAAACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACTGGAGAGGTCATCTGTCAGGTAGCTGA
AGGGGACAAGGGACCGGACCTACCTGGCGATGGTGCAGGAGGCGGAGAAGTACAAAGCGGAGGACGAGGTGCAGCGCGAGAGGGTGTCAG
CCAAGAACGCCCTGGAGTCCTACGCCTTCAACATGAAGAGCGCCGTGGAGGATGAGGGGCTCAAGGGCAAGATCAGCGAGGCGGACAAGA
AGAAGGTGCTGGACAAGTGTCAAGAGGTCATCTCGTGGCTGGACGCCAACACCTTGGCCGAGAAGGACGAGTTTGAGCACAAGAGGAAGG
AGCTGGAGCAGGTGTGTAACCCCATCATCAGCGGACTGTACCAGGGTGCCGGTGGTCCCGGGCCTGGGGGCTTCGGGGCTCAGGGTCCCA
AGGGAGGGTCTGGGTCAGGCCCCACCATTGAGGAGGTAGATTAGGGGCCTTTCCAAGATTGCTGTTTTTGTTTTGGAGCTTCAAGACTTT
GCATTTCCTAGTATTTCTGTTTGTCAGTTCTCAATTTCCTGTGTTTGCAATGTTGAAATTTTTTGGTGAAGTACTGAACTTGCTTTTTTT
CCGGTTTCTACATGCAGAGATGAATTTATACTGCCATCTTACGACTATTTCTTCTTTTTAATACACTTAACTCAGGCCATTTTTTAAGTT

>3874_3874_1_ALDH2-HSPA1A_ALDH2_chr12_112221083_ENST00000261733_HSPA1A_chr6_31785084_ENST00000375651_length(amino acids)=135AA_BP=11
MKGTRDRTYLAMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKR

--------------------------------------------------------------
>3874_3874_2_ALDH2-HSPA1A_ALDH2_chr12_112221083_ENST00000261733_HSPA1A_chr6_31785084_ENST00000458062_length(transcript)=674nt_BP=299nt
TCAGTGGCCCTGAGACCCTAGCTCTGCTCTCGGTCCGCTCGCTGTCCGCTAGCCCGCTGCGATGTTGCGCGCTGCCGCCCGCTTCGGGCC
CCGCCTGGGCCGCCGCCTCTTGTCAGCCGCCGCCACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTT
CATAAACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACTGGAGAGGTCATCTGTCAGGTAGCTGA
AGGGGACAAGGGACCGGACCTACCTGGCGATGGTGCAGGAGGCGGAGAAGTACAAAGCGGAGGACGAGGTGCAGCGCGAGAGGGTGTCAG
CCAAGAACGCCCTGGAGTCCTACGCCTTCAACATGAAGAGCGCCGTGGAGGATGAGGGGCTCAAGGGCAAGATCAGCGAGGCGGACAAGA
AGAAGGTGCTGGACAAGTGTCAAGAGGTCATCTCGTGGCTGGACGCCAACACCTTGGCCGAGAAGGACGAGTTTGAGCACAAGAGGAAGG
AGCTGGAGCAGGTGTGTAACCCCATCATCAGCGGACTGTACCAGGGTGCCGGTGGTCCCGGGCCTGGGGGCTTCGGGGCTCAGGGTCCCA

>3874_3874_2_ALDH2-HSPA1A_ALDH2_chr12_112221083_ENST00000261733_HSPA1A_chr6_31785084_ENST00000458062_length(amino acids)=136AA_BP=11
MKGTRDRTYLAMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKR

--------------------------------------------------------------
>3874_3874_3_ALDH2-HSPA1A_ALDH2_chr12_112221083_ENST00000261733_HSPA1A_chr6_31785084_ENST00000608703_length(transcript)=938nt_BP=299nt
TCAGTGGCCCTGAGACCCTAGCTCTGCTCTCGGTCCGCTCGCTGTCCGCTAGCCCGCTGCGATGTTGCGCGCTGCCGCCCGCTTCGGGCC
CCGCCTGGGCCGCCGCCTCTTGTCAGCCGCCGCCACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTT
CATAAACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACTGGAGAGGTCATCTGTCAGGTAGCTGA
AGGGGACAAGGGACCGGACCTACCTGGCGATGGTGCAGGAGGCGGAGAAGTACAAAGCGGAGGACGAGGTGCAGCGCGAGAGGGTGTCAG
CCAAGAACGCCCTGGAGTCCTACGCCTTCAACATGAAGAGCGCCGTGGAGGATGAGGGGCTCAAGGGCAAGATCAGCGAGGCGGACAAGA
AGAAGGTGCTGGACAAGTGTCAAGAGGTCATCTCGTGGCTGGACGCCAACACCTTGGCCGAGAAGGACGAGTTTGAGCACAAGAGGAAGG
AGCTGGAGCAGGTGTGTAACCCCATCATCAGCGGACTGTACCAGGGTGCCGGTGGTCCCGGGCCTGGGGGCTTCGGGGCTCAGGGTCCCA
AGGGAGGGTCTGGGTCAGGCCCCACCATTGAGGAGGTAGATTAGGGGCCTTTCCAAGATTGCTGTTTTTGTTTTGGAGCTTCAAGACTTT
GCATTTCCTAGTATTTCTGTTTGTCAGTTCTCAATTTCCTGTGTTTGCAATGTTGAAATTTTTTGGTGAAGTACTGAACTTGCTTTTTTT
CCGGTTTCTACATGCAGAGATGAATTTATACTGCCATCTTACGACTATTTCTTCTTTTTAATACACTTAACTCAGGCCATTTTTTAAGTT

>3874_3874_3_ALDH2-HSPA1A_ALDH2_chr12_112221083_ENST00000261733_HSPA1A_chr6_31785084_ENST00000608703_length(amino acids)=135AA_BP=11
MKGTRDRTYLAMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ALDH2-HSPA1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ALDH2-HSPA1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneALDH2P05091DB00536GuanidineInhibitorSmall moleculeApproved
HgeneALDH2P05091DB00536GuanidineInhibitorSmall moleculeApproved
HgeneALDH2P05091DB00822DisulfiramInhibitorSmall moleculeApproved
HgeneALDH2P05091DB00822DisulfiramInhibitorSmall moleculeApproved
HgeneALDH2P05091DB00157NADHSmall moleculeApproved|Nutraceutical
HgeneALDH2P05091DB00157NADHSmall moleculeApproved|Nutraceutical

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Related Diseases for ALDH2-HSPA1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALDH2C0001973Alcoholic Intoxication, Chronic7CTD_human;PSYGENET
HgeneALDH2C0085762Alcohol abuse7CTD_human;PSYGENET
HgeneALDH2C0001969Alcoholic Intoxication5PSYGENET
HgeneALDH2C0393756Hangover from alcohol4PSYGENET
HgeneALDH2C0236664Alcohol-Related Disorders3PSYGENET
HgeneALDH2C0001956Alcohol Use Disorder2CTD_human
HgeneALDH2C0004096Asthma2CTD_human
HgeneALDH2C0005586Bipolar Disorder2PSYGENET
HgeneALDH2C0279626Squamous cell carcinoma of esophagus2CTD_human
HgeneALDH2C0009402Colorectal Carcinoma1CTD_human
HgeneALDH2C0009404Colorectal Neoplasms1CTD_human
HgeneALDH2C0014859Esophageal Neoplasms1CTD_human
HgeneALDH2C0016382Flushing1CTD_human
HgeneALDH2C0016689Freckles1CTD_human
HgeneALDH2C0021364Male infertility1CTD_human
HgeneALDH2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneALDH2C0025209Melanosis1CTD_human
HgeneALDH2C0025218Chloasma1CTD_human
HgeneALDH2C0028796Dermatitis, Occupational1CTD_human
HgeneALDH2C0032927Precancerous Conditions1CTD_human
HgeneALDH2C0042373Vascular Diseases1CTD_human
HgeneALDH2C0086457Industrial Dermatosis1CTD_human
HgeneALDH2C0236970Alcohol-Induced Disorders1CTD_human
HgeneALDH2C0242973Ventricular Dysfunction1CTD_human
HgeneALDH2C0282313Condition, Preneoplastic1CTD_human
HgeneALDH2C0342257Complications of Diabetes Mellitus1CTD_human
HgeneALDH2C0349464Wernicke-Korsakoff Syndrome1PSYGENET
HgeneALDH2C0400966Non-alcoholic Fatty Liver Disease1CTD_human
HgeneALDH2C0520459Necrotizing Enterocolitis1CTD_human
HgeneALDH2C0546837Malignant neoplasm of esophagus1CTD_human
HgeneALDH2C0848676Subfertility, Male1CTD_human
HgeneALDH2C0917731Male sterility1CTD_human
HgeneALDH2C2674838ALCOHOL SENSITIVITY, ACUTE1CTD_human
HgeneALDH2C3241937Nonalcoholic Steatohepatitis1CTD_human
TgeneC0036341Schizophrenia5PSYGENET
TgeneC0041696Unipolar Depression3PSYGENET
TgeneC1269683Major Depressive Disorder3PSYGENET
TgeneC0022660Kidney Failure, Acute2CTD_human
TgeneC1565662Acute Kidney Insufficiency2CTD_human
TgeneC2609414Acute kidney injury2CTD_human
TgeneC0013182Drug Allergy1CTD_human
TgeneC0023895Liver diseases1CTD_human
TgeneC0024517Major depression, single episode1PSYGENET
TgeneC0025202melanoma1CTD_human
TgeneC0027627Neoplasm Metastasis1CTD_human
TgeneC0030567Parkinson Disease1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0035126Reperfusion Injury1CTD_human
TgeneC0036349Paranoid Schizophrenia1PSYGENET
TgeneC0086565Liver Dysfunction1CTD_human
TgeneC0151744Myocardial Ischemia1CTD_human
TgeneC0282507Heat Stress Disorders1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC0887833Carcinoma, Pancreatic Ductal1CTD_human