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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ALDH2-LIN7A (FusionGDB2 ID:HG217TG8825) |
Fusion Gene Summary for ALDH2-LIN7A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ALDH2-LIN7A | Fusion gene ID: hg217tg8825 | Hgene | Tgene | Gene symbol | ALDH2 | LIN7A | Gene ID | 217 | 8825 |
| Gene name | aldehyde dehydrogenase 2 family member | lin-7 homolog A, crumbs cell polarity complex component | |
| Synonyms | ALDH-E2|ALDHI|ALDM | LIN-7A|LIN7|MALS-1|MALS1|TIP-33|VELI1 | |
| Cytomap | ('ALDH2')('LIN7A') 12q24.12 | 12q21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | aldehyde dehydrogenase, mitochondrialALDH class 2acetaldehyde dehydrogenase 2aldehyde dehydrogenase 2 family (mitochondrial)epididymis secretory sperm binding proteinliver mitochondrial ALDHnucleus-encoded mitochondrial aldehyde dehydrogenase 2 | protein lin-7 homolog Amammalian lin-seven protein 1tax interaction protein 33vertebrate LIN7 homolog 1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P05091 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000261733, ENST00000416293, | ||
| Fusion gene scores | * DoF score | 26 X 20 X 11=5720 | 12 X 5 X 4=240 |
| # samples | 21 | 7 | |
| ** MAII score | log2(21/5720*10)=-4.76755391399963 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/240*10)=-1.77760757866355 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ALDH2 [Title/Abstract] AND LIN7A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ALDH2(112204900)-LIN7A(81242101), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ALDH2-LIN7A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ALDH2-LIN7A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ALDH2-LIN7A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ALDH2-LIN7A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across ALDH2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across LIN7A (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-3B-A9HO-01A | ALDH2 | chr12 | 112204900 | - | LIN7A | chr12 | 81242101 | - |
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Fusion Gene ORF analysis for ALDH2-LIN7A |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261733 | ENST00000552864 | ALDH2 | chr12 | 112204900 | - | LIN7A | chr12 | 81242101 | - |
| In-frame | ENST00000416293 | ENST00000552864 | ALDH2 | chr12 | 112204900 | - | LIN7A | chr12 | 81242101 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000416293 | ALDH2 | chr12 | 112204900 | - | ENST00000552864 | LIN7A | chr12 | 81242101 | - | 5918 | 210 | 96 | 710 | 204 |
| ENST00000261733 | ALDH2 | chr12 | 112204900 | - | ENST00000552864 | LIN7A | chr12 | 81242101 | - | 5883 | 175 | 61 | 675 | 204 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000416293 | ENST00000552864 | ALDH2 | chr12 | 112204900 | - | LIN7A | chr12 | 81242101 | - | 0.001411533 | 0.9985884 |
| ENST00000261733 | ENST00000552864 | ALDH2 | chr12 | 112204900 | - | LIN7A | chr12 | 81242101 | - | 0.001407128 | 0.9985929 |
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Fusion Genomic Features for ALDH2-LIN7A |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for ALDH2-LIN7A |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:112204900/chr12:81242101) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ALDH2 | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | LIN7A | chr12:112204900 | chr12:81242101 | ENST00000552864 | 1 | 6 | 210_213 | 67 | 1908.0 | Compositional bias | Note=Poly-Gln | |
| Tgene | LIN7A | chr12:112204900 | chr12:81242101 | ENST00000552864 | 1 | 6 | 217_229 | 67 | 1908.0 | Compositional bias | Note=Poly-Gln | |
| Tgene | LIN7A | chr12:112204900 | chr12:81242101 | ENST00000552864 | 1 | 6 | 108_190 | 67 | 1908.0 | Domain | PDZ |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ALDH2 | chr12:112204900 | chr12:81242101 | ENST00000261733 | - | 1 | 13 | 262_267 | 38 | 518.0 | Nucleotide binding | NAD |
| Hgene | ALDH2 | chr12:112204900 | chr12:81242101 | ENST00000416293 | - | 1 | 12 | 262_267 | 38 | 471.0 | Nucleotide binding | NAD |
| Tgene | LIN7A | chr12:112204900 | chr12:81242101 | ENST00000552864 | 1 | 6 | 25_80 | 67 | 1908.0 | Domain | L27 | |
| Tgene | LIN7A | chr12:112204900 | chr12:81242101 | ENST00000552864 | 1 | 6 | 14_28 | 67 | 1908.0 | Motif | Note=Kinase interacting site |
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Fusion Gene Sequence for ALDH2-LIN7A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >3878_3878_1_ALDH2-LIN7A_ALDH2_chr12_112204900_ENST00000261733_LIN7A_chr12_81242101_ENST00000552864_length(transcript)=5883nt_BP=175nt TCAGTGGCCCTGAGACCCTAGCTCTGCTCTCGGTCCGCTCGCTGTCCGCTAGCCCGCTGCGATGTTGCGCGCTGCCGCCCGCTTCGGGCC CCGCCTGGGCCGCCGCCTCTTGTCAGCCGCCGCCACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGGTGTA TCAATATATGCATGAAACGATAACTGTTAATGGCTGTCCCGAATTCCGTGCGAGGGCAACAGCAAAGGCAACAGTTGCAGCTTTTGCAGC TAGTGAAGGCCACTCCCACCCTCGAGTAGTTGAACTGCCAAAGACTGATGAAGGCCTTGGTTTTAATGTGATGGGAGGAAAGGAGCAAAA TTCCCCCATTTATATCTCTCGCATAATTCCTGGAGGGGTGGCTGAAAGACACGGAGGCCTCAAAAGAGGAGACCAGCTGCTATCAGTGAA CGGAGTGAGTGTGGAAGGAGAACACCATGAGAAAGCTGTGGAACTACTCAAGGCTGCTAAAGACAGCGTCAAGCTGGTGGTGCGATACAC CCCAAAAGTTCTGGAAGAAATGGAGGCTCGCTTTGAAAAGCTACGAACAGCCAGGCGTCGGCAGCAGCAGCAATTGCTAATTCAGCAGCA GCAACAGCAGCAGCAGCAACAAACACAACAAAACCACATGTCATAGGCCCTTGAGGGAAAGCTACTTGATCAAACATCCGATAGTCACAA ATTTGAAACCGTGCTTCAGAATCCCAGCACATAGTAAAAGACAACACTGATAATTATACCTGTCAAGAAGCTGTGAACACATGGTGTATA AATTCTTTACCAAGGCAACTCAACACCTTCTTTCTCTGGGCTTGAACCGCCACTGCTCACGTGGGCTTTACATACATTGACCTTCCATTC ACTGCAGTGGGAATTCTCAGTGTGCAGAGGGAGAGGTTTTCTAGTCTGCAAACTGAAACAGTGTAAGAAGAATAAAGTCTATGACTTTTA AATAAATCACCAGGGCCAAGATTGAGTGAATCTTGGGTCCATAGCTTTTCCAGATATTAGCAAACCCCTCATTAGGCTATAATTCAAACT GCATCAGTTCAAAGTGAAACCTACACATTGCTCCTTACCCTCACCTGCTCCACAATCCATAGTGCTGAGTTGTCTGAATTGGAATTCCAG TTAATTGCAAGTTCAACCTGTTTTCCTCTTGAAAATCGCAAGGTATCATACTATATTTATATTTTCTTCAGGTTCTAGAAGCAATCGGCT TTTTCTTTTGTTTCCATGAATTTTATTATGCATTAATAGAATGGACCAATTTTAGCTCAACTTTTAGTTTGTTAGAAGCAAGTGTAGGAA CTCTAGCACTGTAGTTTTTAATTATTGCTTGTATCTATTATTATTAATTCCAACAGAGTATAATGTATATTTATTCTATAAAATATATAT TATCAGAGTGCATTTGTTACAACTTAGGTTCTTTTCTTACCAAGTATTAAGAATCTAGTAAGAGAATACTAGCAAAGGACCTAGCCCTGT GAACAGATTCTCGTATGTTATATACATAAACCCACTCTCAATATTTTTTGAGTTTTATACTTTTTGATTGATAAACACTGAAGAAATCTA AACTCTACTCACACTGATGTGCTGTCATAGAAGCCTATTTCATATTTTAAAGCTTAGCAAAACTAAATTATATGTGCATATATATTCAAA TATTTGTGTCACACAAAGTTTAGGTCAATTTCCCCAAATATAAACCAGATATTTTTGGCACTCTCAGATAAACAAGTATTATTTCTCTTA TAATTGGGCAGGTGGAAACCAGTGATATCAATATTGTGAATGGCAGATGCTGCTTCCTCTAGAAAAATAAAATAAAATCACCAACTTTAA TATATTCCCATAGGTAAATAGACAATGAGATATCATTTTTCAGAAAATATCATTCACTGGAAAATAATCTGTTATAACTACATTTACAGG TCATAATTTTTGGTTTATGGTAAATCTAGGCACCTAAGTCTGATTTTACTTTATGAAATAAATAGGAAGCAATAATTGTTTGGGCATTTG AATACCTTAAGCACATAAATGAACCTAAGAAAAGAATAATTGCTTAGTTGAAGTATTCAAAATAGATCAGTAAACCACAGGCAAATATTT GAATGTTCCCTTTTCTCAAATACAGAAATTGATTCCCCAAGATACAATACAATTTGACACTTCAGATAATCCCCCAAAATAGAAATGTAT GAAGCTCAGTTTAGACTGTCTTCTTGAAAATAAAACAAAACCAATCAAAACTACCCAGCACATTTTATTATGCCCTGTTGGGTGATAGTA TTGTCAATACCAGGTTTTCCCTGCTCTTCACAATGCATCCCTCACCAGAGGAAAAACAGCAAGAAAACTAGGACATTTGCTAATTTCAAC AATACACCCCTGTGATAACAGATTCCCATCCTTGAATACATATCATTTTTTACTAGAGAGAACGGGGGTGGTGAGGTGGGGGCAGTTAGG ACCCTGTATGTTATGTAAAATAGATTTACAAAAAGGACAAGCATGATAAAAGGGAATGAATGGAGACGATGTATTATTCAGTTTGAAAGA GATAGTTCACATTTTTATAAGAAAAATTTAATAAAACATATATTTTAGTTATCATTTAACAAAGATATATTAAAGCTATTCAGGCAATGC CACAGGATTCTCATGAAGGGAAATCACTGAACCCTTGTCATGAGAAAATGGTCATTTCAACACATTTCAATACATTGTATAAATTTGGAG CTTAAGGTGAGTGAGTATGTTTTCACTTAGTCATAAATGTTTGGTCAAAATTAAAGTTATCATATGGTTTCACATCAATACAAATATTGT CACAGTGTTACAGAAACAACTATCAAATGGTAAGATAGTTTACATTTGTGTTTTCTAGAAACCTTTGTATTTATGCTTCATTTGGTTAAT GTTAAGTGCTGATAAAGGCATACCAGATTGTTTGTCAAAGTAAAGAAGCAATCCATCACACCTAGGACATCTAAGGATGGATTATACGTC AGAGTGGTCTCATATACAAATGACCATTTTCCTTCAGTAAAATCTTGTTGGTTGAAATGTAAGTCTTTTCCTAAAGTTTTAATCAGAGGT AGCCATCACTAAGACTTAAGCCACCTGTGGTTCTCTTAAGTTTCACTGAAGCCAGAAGAAGGAAATTACCACAACTTGTATTATACTAAT TATCTTCATTATTAACGATCATATTAGAGCCACTGACATGTCCCAAATTATATTAAAATAAAAACCTGCATTGCTCTGACATGAAGCTCA ATTCAATGTAATAAACAAATTAGGTATTAAACGTTATAATTTAAAAAACTTCTACGATATCACCAGAAATCCTGGTGAAATTTAATTTTT TCCCTTTTTTAGGTCAGTGGCCGGTGGGATAGATTTTTCTAAACTTTTTCCTGCTATGATTTTGAAGGCAAATACATAGAGCACAGTTCA GTAAAAGAGTTTCCAAGCCTTTTCACTGGAGCATTTACATTTTGATTCTGTTGTCATTTGAAATAGAACATCTGCAGGGAGATAATGAGC TTAAGTTACAATTGACTTTGGAAAGAATAACAGACTTTTGTGTTTCCTCAATCATGTAGTCAATAGGGAATTCTCCAGTTATGTGAACAA TCACAGTCTTTTAAGACAATACTTAGATCTAAATGCAAAATCTAGCATGCAGAGGCTTTTTAAGGATTTTAGACTGTCTCCAAAGAACTT GGCTCGAGATGGATTACACAGATTTACAAATGCAGTTTTCAACTGTGACATCAAACTGATCTTATCTCATTTCATGTTACTCAACTGTGC CCGTAGGACCCCAAGAGGTGGAATATTTTGTCTACATTATTTTAAACATCTATAGATATGTGTGGATGTGTGAATAATGCCTAAATTTCT CATCTTTTAACTAGTTTGTTTTTATCATACAGACACAGCCTGTTCATAAGACCAGCTTTAGACAACTTAGAACTCAATGCTCTGAAGATT CAGGGAGGCCAACATAGAAAAAGATCTTCCAAAATATGGGGTGGTCCAACCCATCTCATCCCTCTCTAGCTGGAAAACTATAGAGAAAGG GCTGTGACTGCCTTGACCACTGCCTGGCACAATGTAGGCACTCGGTATTTGTTGGATGAATAAGTGGCTGAATCAGTGAATAGACAAAAA ACATGGATTTTGCCTTCTGAAAATCTCACAAATTTTACCAGCTTATATTATACTGATTGTCACTATGATTTCTAAGTTTCATGGTTAGAA CCATATTTTGAGTCTATATAAAAACTTTTTAGATGTATGAATTTGAAATTTCATTAATTACTTTAAAGGCTTCAAAGATTTGAGGACATT TGAACAGTGGATAAGGAACAATGTTTGGGGATACAGAGTTTTTATGCTGAGTTGAACTCAACCTTTCTAGTTCTTTATACAAGCTTCCTG AATTATCTGGCAGGAATGATTCAAACATAAAACCCCATTTTTAAATTTTATAAAAGATATTTTCATTTTTATATAAAAAGATCATCAGGC ATATTATCCCCTTTGATATTTATTAACAACCATTCTCTAAGAAATTCATAATAATTGGAGACACCATCCCTAAATCTCTTCCTATTTTCA AAAGATCATTTATCCTTTCATATTTGATTCCTGGAATACACTAAGCTGAAGTTTAATCACATACTTACTCAGATGTTTCCATGTGTTTAT TCATTTAACAAATACTTATTGTGTACCTAGTGCATGCTAGGTTCTGGAAATGCAACAGCAAACAAGACAGACACAATCCCTCTTGGAGGT TACTGTGAGAAACTCTCCAACATTTACTCTAGCAATAACTAGAGAGTTTACTGTCCATTGGGTCCTCTTCACACCTGATAGAAAAAATAA AATTCCTCACCCCATGGAAGTCATGAAATACTCCCTGCACAGATTTGTGTGAGCTTGCTTTTCTAAAACCACTGCTCAAAAATGCTGCTT AGTTTATCTATAAACCACGGTTATACCCCAGTGAGGTAGGTAAGTAATTTATTCATAACTAACATTTATGCAGCTCTATTTTCTAGCCAC TGTGCTGAGTGCTTTTATGGACTATCTCACCAAATCCCTTCAACAACTCTATTCAGTAGGTTCCATTTTATAGATACAAAAACTGAAGCA CAGATATATTATGTGACTTGTCCAAGGTCACACAGCTAGCAGGTGGAACTGGGATTTGAACCCATGCAATCTGACACAAGAGTTCATGTG TCTAATCATTATCTGTGGTTTGGGGGACACCATTACATTAAAATGAATGAGTCACTAAGTGAGTCACTGTATATAAAATACTTGGAAATT GTAAAGTAATATACAAAAGATATTAACAAAGTATTATTCATGGTAAACAAATCACATCAGTAGCAAACACAGGGTGGGAACTCAATCTTA TGTTATAGCTTACTCTTAAGAAGAATATGTGAAGCCAGGAACATGGTTAAAGGTACAGACCAGAAAATTTCTGACATGTGATAAATATTT CAGTGACTTTTCAGATTTATTTCTTGTTAGCCGCTGTGTCTATTTGGTGCTACAAAAACTGAAAGAAACAAAATCCCTGATGTAAGGGCT TATAATAAATACACAGTTTGGAGATGAACTAAGGATATTTTACATTTACGGGAAAGGATTGGACAATAGTATCATTTTCTCACCATTTGC ATGTACATCATGTCTTTCCAATTGTTTTCATTATTTTTCTGAAAGAGCTGCAAAATTGTGCAGTGGTTCAACCTGACCAAAGTGGTATTA >3878_3878_1_ALDH2-LIN7A_ALDH2_chr12_112204900_ENST00000261733_LIN7A_chr12_81242101_ENST00000552864_length(amino acids)=204AA_BP=38 MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQVYQYMHETITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLG FNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLRTARRR -------------------------------------------------------------- >3878_3878_2_ALDH2-LIN7A_ALDH2_chr12_112204900_ENST00000416293_LIN7A_chr12_81242101_ENST00000552864_length(transcript)=5918nt_BP=210nt ATTGGCTGCCGCGCGGGGCGGGGAGCGGGGTCGGCTCAGTGGCCCTGAGACCCTAGCTCTGCTCTCGGTCCGCTCGCTGTCCGCTAGCCC GCTGCGATGTTGCGCGCTGCCGCCCGCTTCGGGCCCCGCCTGGGCCGCCGCCTCTTGTCAGCCGCCGCCACCCAGGCCGTGCCTGCCCCC AACCAGCAGCCCGAGGTCTTCTGCAACCAGGTGTATCAATATATGCATGAAACGATAACTGTTAATGGCTGTCCCGAATTCCGTGCGAGG GCAACAGCAAAGGCAACAGTTGCAGCTTTTGCAGCTAGTGAAGGCCACTCCCACCCTCGAGTAGTTGAACTGCCAAAGACTGATGAAGGC CTTGGTTTTAATGTGATGGGAGGAAAGGAGCAAAATTCCCCCATTTATATCTCTCGCATAATTCCTGGAGGGGTGGCTGAAAGACACGGA GGCCTCAAAAGAGGAGACCAGCTGCTATCAGTGAACGGAGTGAGTGTGGAAGGAGAACACCATGAGAAAGCTGTGGAACTACTCAAGGCT GCTAAAGACAGCGTCAAGCTGGTGGTGCGATACACCCCAAAAGTTCTGGAAGAAATGGAGGCTCGCTTTGAAAAGCTACGAACAGCCAGG CGTCGGCAGCAGCAGCAATTGCTAATTCAGCAGCAGCAACAGCAGCAGCAGCAACAAACACAACAAAACCACATGTCATAGGCCCTTGAG GGAAAGCTACTTGATCAAACATCCGATAGTCACAAATTTGAAACCGTGCTTCAGAATCCCAGCACATAGTAAAAGACAACACTGATAATT ATACCTGTCAAGAAGCTGTGAACACATGGTGTATAAATTCTTTACCAAGGCAACTCAACACCTTCTTTCTCTGGGCTTGAACCGCCACTG CTCACGTGGGCTTTACATACATTGACCTTCCATTCACTGCAGTGGGAATTCTCAGTGTGCAGAGGGAGAGGTTTTCTAGTCTGCAAACTG AAACAGTGTAAGAAGAATAAAGTCTATGACTTTTAAATAAATCACCAGGGCCAAGATTGAGTGAATCTTGGGTCCATAGCTTTTCCAGAT ATTAGCAAACCCCTCATTAGGCTATAATTCAAACTGCATCAGTTCAAAGTGAAACCTACACATTGCTCCTTACCCTCACCTGCTCCACAA TCCATAGTGCTGAGTTGTCTGAATTGGAATTCCAGTTAATTGCAAGTTCAACCTGTTTTCCTCTTGAAAATCGCAAGGTATCATACTATA TTTATATTTTCTTCAGGTTCTAGAAGCAATCGGCTTTTTCTTTTGTTTCCATGAATTTTATTATGCATTAATAGAATGGACCAATTTTAG CTCAACTTTTAGTTTGTTAGAAGCAAGTGTAGGAACTCTAGCACTGTAGTTTTTAATTATTGCTTGTATCTATTATTATTAATTCCAACA GAGTATAATGTATATTTATTCTATAAAATATATATTATCAGAGTGCATTTGTTACAACTTAGGTTCTTTTCTTACCAAGTATTAAGAATC TAGTAAGAGAATACTAGCAAAGGACCTAGCCCTGTGAACAGATTCTCGTATGTTATATACATAAACCCACTCTCAATATTTTTTGAGTTT TATACTTTTTGATTGATAAACACTGAAGAAATCTAAACTCTACTCACACTGATGTGCTGTCATAGAAGCCTATTTCATATTTTAAAGCTT AGCAAAACTAAATTATATGTGCATATATATTCAAATATTTGTGTCACACAAAGTTTAGGTCAATTTCCCCAAATATAAACCAGATATTTT TGGCACTCTCAGATAAACAAGTATTATTTCTCTTATAATTGGGCAGGTGGAAACCAGTGATATCAATATTGTGAATGGCAGATGCTGCTT CCTCTAGAAAAATAAAATAAAATCACCAACTTTAATATATTCCCATAGGTAAATAGACAATGAGATATCATTTTTCAGAAAATATCATTC ACTGGAAAATAATCTGTTATAACTACATTTACAGGTCATAATTTTTGGTTTATGGTAAATCTAGGCACCTAAGTCTGATTTTACTTTATG AAATAAATAGGAAGCAATAATTGTTTGGGCATTTGAATACCTTAAGCACATAAATGAACCTAAGAAAAGAATAATTGCTTAGTTGAAGTA TTCAAAATAGATCAGTAAACCACAGGCAAATATTTGAATGTTCCCTTTTCTCAAATACAGAAATTGATTCCCCAAGATACAATACAATTT GACACTTCAGATAATCCCCCAAAATAGAAATGTATGAAGCTCAGTTTAGACTGTCTTCTTGAAAATAAAACAAAACCAATCAAAACTACC CAGCACATTTTATTATGCCCTGTTGGGTGATAGTATTGTCAATACCAGGTTTTCCCTGCTCTTCACAATGCATCCCTCACCAGAGGAAAA ACAGCAAGAAAACTAGGACATTTGCTAATTTCAACAATACACCCCTGTGATAACAGATTCCCATCCTTGAATACATATCATTTTTTACTA GAGAGAACGGGGGTGGTGAGGTGGGGGCAGTTAGGACCCTGTATGTTATGTAAAATAGATTTACAAAAAGGACAAGCATGATAAAAGGGA ATGAATGGAGACGATGTATTATTCAGTTTGAAAGAGATAGTTCACATTTTTATAAGAAAAATTTAATAAAACATATATTTTAGTTATCAT TTAACAAAGATATATTAAAGCTATTCAGGCAATGCCACAGGATTCTCATGAAGGGAAATCACTGAACCCTTGTCATGAGAAAATGGTCAT TTCAACACATTTCAATACATTGTATAAATTTGGAGCTTAAGGTGAGTGAGTATGTTTTCACTTAGTCATAAATGTTTGGTCAAAATTAAA GTTATCATATGGTTTCACATCAATACAAATATTGTCACAGTGTTACAGAAACAACTATCAAATGGTAAGATAGTTTACATTTGTGTTTTC TAGAAACCTTTGTATTTATGCTTCATTTGGTTAATGTTAAGTGCTGATAAAGGCATACCAGATTGTTTGTCAAAGTAAAGAAGCAATCCA TCACACCTAGGACATCTAAGGATGGATTATACGTCAGAGTGGTCTCATATACAAATGACCATTTTCCTTCAGTAAAATCTTGTTGGTTGA AATGTAAGTCTTTTCCTAAAGTTTTAATCAGAGGTAGCCATCACTAAGACTTAAGCCACCTGTGGTTCTCTTAAGTTTCACTGAAGCCAG AAGAAGGAAATTACCACAACTTGTATTATACTAATTATCTTCATTATTAACGATCATATTAGAGCCACTGACATGTCCCAAATTATATTA AAATAAAAACCTGCATTGCTCTGACATGAAGCTCAATTCAATGTAATAAACAAATTAGGTATTAAACGTTATAATTTAAAAAACTTCTAC GATATCACCAGAAATCCTGGTGAAATTTAATTTTTTCCCTTTTTTAGGTCAGTGGCCGGTGGGATAGATTTTTCTAAACTTTTTCCTGCT ATGATTTTGAAGGCAAATACATAGAGCACAGTTCAGTAAAAGAGTTTCCAAGCCTTTTCACTGGAGCATTTACATTTTGATTCTGTTGTC ATTTGAAATAGAACATCTGCAGGGAGATAATGAGCTTAAGTTACAATTGACTTTGGAAAGAATAACAGACTTTTGTGTTTCCTCAATCAT GTAGTCAATAGGGAATTCTCCAGTTATGTGAACAATCACAGTCTTTTAAGACAATACTTAGATCTAAATGCAAAATCTAGCATGCAGAGG CTTTTTAAGGATTTTAGACTGTCTCCAAAGAACTTGGCTCGAGATGGATTACACAGATTTACAAATGCAGTTTTCAACTGTGACATCAAA CTGATCTTATCTCATTTCATGTTACTCAACTGTGCCCGTAGGACCCCAAGAGGTGGAATATTTTGTCTACATTATTTTAAACATCTATAG ATATGTGTGGATGTGTGAATAATGCCTAAATTTCTCATCTTTTAACTAGTTTGTTTTTATCATACAGACACAGCCTGTTCATAAGACCAG CTTTAGACAACTTAGAACTCAATGCTCTGAAGATTCAGGGAGGCCAACATAGAAAAAGATCTTCCAAAATATGGGGTGGTCCAACCCATC TCATCCCTCTCTAGCTGGAAAACTATAGAGAAAGGGCTGTGACTGCCTTGACCACTGCCTGGCACAATGTAGGCACTCGGTATTTGTTGG ATGAATAAGTGGCTGAATCAGTGAATAGACAAAAAACATGGATTTTGCCTTCTGAAAATCTCACAAATTTTACCAGCTTATATTATACTG ATTGTCACTATGATTTCTAAGTTTCATGGTTAGAACCATATTTTGAGTCTATATAAAAACTTTTTAGATGTATGAATTTGAAATTTCATT AATTACTTTAAAGGCTTCAAAGATTTGAGGACATTTGAACAGTGGATAAGGAACAATGTTTGGGGATACAGAGTTTTTATGCTGAGTTGA ACTCAACCTTTCTAGTTCTTTATACAAGCTTCCTGAATTATCTGGCAGGAATGATTCAAACATAAAACCCCATTTTTAAATTTTATAAAA GATATTTTCATTTTTATATAAAAAGATCATCAGGCATATTATCCCCTTTGATATTTATTAACAACCATTCTCTAAGAAATTCATAATAAT TGGAGACACCATCCCTAAATCTCTTCCTATTTTCAAAAGATCATTTATCCTTTCATATTTGATTCCTGGAATACACTAAGCTGAAGTTTA ATCACATACTTACTCAGATGTTTCCATGTGTTTATTCATTTAACAAATACTTATTGTGTACCTAGTGCATGCTAGGTTCTGGAAATGCAA CAGCAAACAAGACAGACACAATCCCTCTTGGAGGTTACTGTGAGAAACTCTCCAACATTTACTCTAGCAATAACTAGAGAGTTTACTGTC CATTGGGTCCTCTTCACACCTGATAGAAAAAATAAAATTCCTCACCCCATGGAAGTCATGAAATACTCCCTGCACAGATTTGTGTGAGCT TGCTTTTCTAAAACCACTGCTCAAAAATGCTGCTTAGTTTATCTATAAACCACGGTTATACCCCAGTGAGGTAGGTAAGTAATTTATTCA TAACTAACATTTATGCAGCTCTATTTTCTAGCCACTGTGCTGAGTGCTTTTATGGACTATCTCACCAAATCCCTTCAACAACTCTATTCA GTAGGTTCCATTTTATAGATACAAAAACTGAAGCACAGATATATTATGTGACTTGTCCAAGGTCACACAGCTAGCAGGTGGAACTGGGAT TTGAACCCATGCAATCTGACACAAGAGTTCATGTGTCTAATCATTATCTGTGGTTTGGGGGACACCATTACATTAAAATGAATGAGTCAC TAAGTGAGTCACTGTATATAAAATACTTGGAAATTGTAAAGTAATATACAAAAGATATTAACAAAGTATTATTCATGGTAAACAAATCAC ATCAGTAGCAAACACAGGGTGGGAACTCAATCTTATGTTATAGCTTACTCTTAAGAAGAATATGTGAAGCCAGGAACATGGTTAAAGGTA CAGACCAGAAAATTTCTGACATGTGATAAATATTTCAGTGACTTTTCAGATTTATTTCTTGTTAGCCGCTGTGTCTATTTGGTGCTACAA AAACTGAAAGAAACAAAATCCCTGATGTAAGGGCTTATAATAAATACACAGTTTGGAGATGAACTAAGGATATTTTACATTTACGGGAAA GGATTGGACAATAGTATCATTTTCTCACCATTTGCATGTACATCATGTCTTTCCAATTGTTTTCATTATTTTTCTGAAAGAGCTGCAAAA >3878_3878_2_ALDH2-LIN7A_ALDH2_chr12_112204900_ENST00000416293_LIN7A_chr12_81242101_ENST00000552864_length(amino acids)=204AA_BP=38 MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQVYQYMHETITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLG FNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLRTARRR -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ALDH2-LIN7A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ALDH2-LIN7A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ALDH2 | P05091 | DB00536 | Guanidine | Inhibitor | Small molecule | Approved |
| Hgene | ALDH2 | P05091 | DB00536 | Guanidine | Inhibitor | Small molecule | Approved |
| Hgene | ALDH2 | P05091 | DB00822 | Disulfiram | Inhibitor | Small molecule | Approved |
| Hgene | ALDH2 | P05091 | DB00822 | Disulfiram | Inhibitor | Small molecule | Approved |
| Hgene | ALDH2 | P05091 | DB00157 | NADH | Small molecule | Approved|Nutraceutical | |
| Hgene | ALDH2 | P05091 | DB00157 | NADH | Small molecule | Approved|Nutraceutical |
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Related Diseases for ALDH2-LIN7A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ALDH2 | C0001973 | Alcoholic Intoxication, Chronic | 7 | CTD_human;PSYGENET |
| Hgene | ALDH2 | C0085762 | Alcohol abuse | 7 | CTD_human;PSYGENET |
| Hgene | ALDH2 | C0001969 | Alcoholic Intoxication | 5 | PSYGENET |
| Hgene | ALDH2 | C0393756 | Hangover from alcohol | 4 | PSYGENET |
| Hgene | ALDH2 | C0236664 | Alcohol-Related Disorders | 3 | PSYGENET |
| Hgene | ALDH2 | C0001956 | Alcohol Use Disorder | 2 | CTD_human |
| Hgene | ALDH2 | C0004096 | Asthma | 2 | CTD_human |
| Hgene | ALDH2 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Hgene | ALDH2 | C0279626 | Squamous cell carcinoma of esophagus | 2 | CTD_human |
| Hgene | ALDH2 | C0009402 | Colorectal Carcinoma | 1 | CTD_human |
| Hgene | ALDH2 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Hgene | ALDH2 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
| Hgene | ALDH2 | C0016382 | Flushing | 1 | CTD_human |
| Hgene | ALDH2 | C0016689 | Freckles | 1 | CTD_human |
| Hgene | ALDH2 | C0021364 | Male infertility | 1 | CTD_human |
| Hgene | ALDH2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | ALDH2 | C0025209 | Melanosis | 1 | CTD_human |
| Hgene | ALDH2 | C0025218 | Chloasma | 1 | CTD_human |
| Hgene | ALDH2 | C0028796 | Dermatitis, Occupational | 1 | CTD_human |
| Hgene | ALDH2 | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Hgene | ALDH2 | C0042373 | Vascular Diseases | 1 | CTD_human |
| Hgene | ALDH2 | C0086457 | Industrial Dermatosis | 1 | CTD_human |
| Hgene | ALDH2 | C0236970 | Alcohol-Induced Disorders | 1 | CTD_human |
| Hgene | ALDH2 | C0242973 | Ventricular Dysfunction | 1 | CTD_human |
| Hgene | ALDH2 | C0282313 | Condition, Preneoplastic | 1 | CTD_human |
| Hgene | ALDH2 | C0342257 | Complications of Diabetes Mellitus | 1 | CTD_human |
| Hgene | ALDH2 | C0349464 | Wernicke-Korsakoff Syndrome | 1 | PSYGENET |
| Hgene | ALDH2 | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human |
| Hgene | ALDH2 | C0520459 | Necrotizing Enterocolitis | 1 | CTD_human |
| Hgene | ALDH2 | C0546837 | Malignant neoplasm of esophagus | 1 | CTD_human |
| Hgene | ALDH2 | C0848676 | Subfertility, Male | 1 | CTD_human |
| Hgene | ALDH2 | C0917731 | Male sterility | 1 | CTD_human |
| Hgene | ALDH2 | C2674838 | ALCOHOL SENSITIVITY, ACUTE | 1 | CTD_human |
| Hgene | ALDH2 | C3241937 | Nonalcoholic Steatohepatitis | 1 | CTD_human |
| Tgene | C0007097 | Carcinoma | 1 | CTD_human | |
| Tgene | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human | |
| Tgene | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human | |
| Tgene | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human | |
| Tgene | C0205696 | Anaplastic carcinoma | 1 | CTD_human | |
| Tgene | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human | |
| Tgene | C0205698 | Undifferentiated carcinoma | 1 | CTD_human | |
| Tgene | C0205699 | Carcinomatosis | 1 | CTD_human | |
| Tgene | C1257925 | Mammary Carcinoma, Animal | 1 | CTD_human |
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