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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ACSL1-HERC5 (FusionGDB2 ID:HG2180TG51191) |
Fusion Gene Summary for ACSL1-HERC5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACSL1-HERC5 | Fusion gene ID: hg2180tg51191 | Hgene | Tgene | Gene symbol | ACSL1 | HERC5 | Gene ID | 2180 | 51191 |
| Gene name | acyl-CoA synthetase long chain family member 1 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | |
| Synonyms | ACS1|FACL1|FACL2|LACS|LACS1|LACS2 | CEB1|CEBP1 | |
| Cytomap | ('ACSL1')('HERC5') 4q35.1 | 4q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | long-chain-fatty-acid--CoA ligase 1LACS 1LACS 2acyl-CoA synthetase 1arachidonate--CoA ligasefatty-acid-Coenzyme A ligase, long-chain 1fatty-acid-Coenzyme A ligase, long-chain 2lignoceroyl-CoA synthaselong-chain acyl-CoA synthetase 1long-chain acy | E3 ISG15--protein ligase HERC5HECT domain and RCC1-like domain-containing protein 5cyclin-E-binding protein 1hect domain and RLD 5probable E3 ubiquitin-protein ligase HERC5 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000281455, ENST00000437665, ENST00000454703, ENST00000504342, ENST00000504900, ENST00000507295, ENST00000513317, ENST00000515030, | ||
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ACSL1 [Title/Abstract] AND HERC5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ACSL1(185698038)-HERC5(89407266), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ACSL1-HERC5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACSL1-HERC5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACSL1-HERC5 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ACSL1-HERC5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ACSL1 | GO:0001676 | long-chain fatty acid metabolic process | 22022213|24269233 |
| Hgene | ACSL1 | GO:0008610 | lipid biosynthetic process | 21242590 |
| Hgene | ACSL1 | GO:0044539 | long-chain fatty acid import | 22022213 |
| Tgene | HERC5 | GO:0016567 | protein ubiquitination | 15331633 |
| Tgene | HERC5 | GO:0032020 | ISG15-protein conjugation | 20308324 |
| Tgene | HERC5 | GO:0050688 | regulation of defense response to virus | 20308324 |
| Fusion gene breakpoints across ACSL1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across HERC5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | ERR315425 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
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Fusion Gene ORF analysis for ACSL1-HERC5 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000281455 | ENST00000508695 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| 5CDS-intron | ENST00000437665 | ENST00000508695 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| 5CDS-intron | ENST00000454703 | ENST00000508695 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| 5CDS-intron | ENST00000504342 | ENST00000508695 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| 5CDS-intron | ENST00000504900 | ENST00000508695 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| 5CDS-intron | ENST00000507295 | ENST00000508695 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| 5CDS-intron | ENST00000513317 | ENST00000508695 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| 5CDS-intron | ENST00000515030 | ENST00000508695 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| Frame-shift | ENST00000454703 | ENST00000264350 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| Frame-shift | ENST00000454703 | ENST00000508159 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| Frame-shift | ENST00000504342 | ENST00000264350 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| Frame-shift | ENST00000504342 | ENST00000508159 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| Frame-shift | ENST00000513317 | ENST00000264350 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| Frame-shift | ENST00000513317 | ENST00000508159 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| In-frame | ENST00000281455 | ENST00000264350 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| In-frame | ENST00000281455 | ENST00000508159 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| In-frame | ENST00000437665 | ENST00000264350 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| In-frame | ENST00000437665 | ENST00000508159 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| In-frame | ENST00000504900 | ENST00000264350 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| In-frame | ENST00000504900 | ENST00000508159 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| In-frame | ENST00000507295 | ENST00000264350 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| In-frame | ENST00000507295 | ENST00000508159 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| In-frame | ENST00000515030 | ENST00000264350 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| In-frame | ENST00000515030 | ENST00000508159 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000515030 | ACSL1 | chr4 | 185698038 | - | ENST00000264350 | HERC5 | chr4 | 89407266 | + | 2526 | 903 | 957 | 2240 | 427 |
| ENST00000515030 | ACSL1 | chr4 | 185698038 | - | ENST00000508159 | HERC5 | chr4 | 89407266 | + | 2385 | 903 | 957 | 2240 | 427 |
| ENST00000281455 | ACSL1 | chr4 | 185698038 | - | ENST00000264350 | HERC5 | chr4 | 89407266 | + | 2411 | 788 | 842 | 2125 | 427 |
| ENST00000281455 | ACSL1 | chr4 | 185698038 | - | ENST00000508159 | HERC5 | chr4 | 89407266 | + | 2270 | 788 | 842 | 2125 | 427 |
| ENST00000507295 | ACSL1 | chr4 | 185698038 | - | ENST00000264350 | HERC5 | chr4 | 89407266 | + | 2249 | 626 | 680 | 1963 | 427 |
| ENST00000507295 | ACSL1 | chr4 | 185698038 | - | ENST00000508159 | HERC5 | chr4 | 89407266 | + | 2108 | 626 | 680 | 1963 | 427 |
| ENST00000437665 | ACSL1 | chr4 | 185698038 | - | ENST00000264350 | HERC5 | chr4 | 89407266 | + | 2527 | 904 | 958 | 2241 | 427 |
| ENST00000437665 | ACSL1 | chr4 | 185698038 | - | ENST00000508159 | HERC5 | chr4 | 89407266 | + | 2386 | 904 | 958 | 2241 | 427 |
| ENST00000504900 | ACSL1 | chr4 | 185698038 | - | ENST00000264350 | HERC5 | chr4 | 89407266 | + | 2369 | 746 | 800 | 2083 | 427 |
| ENST00000504900 | ACSL1 | chr4 | 185698038 | - | ENST00000508159 | HERC5 | chr4 | 89407266 | + | 2228 | 746 | 800 | 2083 | 427 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000515030 | ENST00000264350 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + | 0.0003356 | 0.9996644 |
| ENST00000515030 | ENST00000508159 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + | 0.000396136 | 0.9996039 |
| ENST00000281455 | ENST00000264350 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + | 0.0003005 | 0.9996995 |
| ENST00000281455 | ENST00000508159 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + | 0.00034358 | 0.99965644 |
| ENST00000507295 | ENST00000264350 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + | 0.000235241 | 0.99976474 |
| ENST00000507295 | ENST00000508159 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + | 0.000265659 | 0.99973434 |
| ENST00000437665 | ENST00000264350 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + | 0.000203426 | 0.99979657 |
| ENST00000437665 | ENST00000508159 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + | 0.00023 | 0.99977 |
| ENST00000504900 | ENST00000264350 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + | 0.000271546 | 0.9997284 |
| ENST00000504900 | ENST00000508159 | ACSL1 | chr4 | 185698038 | - | HERC5 | chr4 | 89407266 | + | 0.000310405 | 0.9996896 |
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Fusion Genomic Features for ACSL1-HERC5 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| ACSL1 | chr4 | 185698037 | - | HERC5 | chr4 | 89407265 | + | 0.000342943 | 0.99965703 |
| ACSL1 | chr4 | 185698037 | - | HERC5 | chr4 | 89407265 | + | 0.000342943 | 0.99965703 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ACSL1-HERC5 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:185698038/chr4:89407266) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ACSL1 | chr4:185698038 | chr4:89407266 | ENST00000281455 | - | 6 | 21 | 25_45 | 192 | 699.0 | Transmembrane | Helical%3B Signal-anchor for type III membrane protein |
| Hgene | ACSL1 | chr4:185698038 | chr4:89407266 | ENST00000504342 | - | 6 | 21 | 25_45 | 192 | 699.0 | Transmembrane | Helical%3B Signal-anchor for type III membrane protein |
| Hgene | ACSL1 | chr4:185698038 | chr4:89407266 | ENST00000515030 | - | 6 | 21 | 25_45 | 192 | 699.0 | Transmembrane | Helical%3B Signal-anchor for type III membrane protein |
| Tgene | HERC5 | chr4:185698038 | chr4:89407266 | ENST00000264350 | 12 | 23 | 702_1024 | 579 | 1025.0 | Domain | HECT |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ACSL1 | chr4:185698038 | chr4:89407266 | ENST00000281455 | - | 6 | 21 | 46_698 | 192 | 699.0 | Topological domain | Cytoplasmic |
| Hgene | ACSL1 | chr4:185698038 | chr4:89407266 | ENST00000504342 | - | 6 | 21 | 46_698 | 192 | 699.0 | Topological domain | Cytoplasmic |
| Hgene | ACSL1 | chr4:185698038 | chr4:89407266 | ENST00000515030 | - | 6 | 21 | 46_698 | 192 | 699.0 | Topological domain | Cytoplasmic |
| Tgene | HERC5 | chr4:185698038 | chr4:89407266 | ENST00000264350 | 12 | 23 | 156_208 | 579 | 1025.0 | Repeat | Note=RCC1 2 | |
| Tgene | HERC5 | chr4:185698038 | chr4:89407266 | ENST00000264350 | 12 | 23 | 209_260 | 579 | 1025.0 | Repeat | Note=RCC1 3 | |
| Tgene | HERC5 | chr4:185698038 | chr4:89407266 | ENST00000264350 | 12 | 23 | 262_312 | 579 | 1025.0 | Repeat | Note=RCC1 4 | |
| Tgene | HERC5 | chr4:185698038 | chr4:89407266 | ENST00000264350 | 12 | 23 | 314_364 | 579 | 1025.0 | Repeat | Note=RCC1 5 | |
| Tgene | HERC5 | chr4:185698038 | chr4:89407266 | ENST00000264350 | 12 | 23 | 96_155 | 579 | 1025.0 | Repeat | Note=RCC1 1 |
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Fusion Gene Sequence for ACSL1-HERC5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >1493_1493_1_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000281455_HERC5_chr4_89407266_ENST00000264350_length(transcript)=2411nt_BP=788nt GGGGCCGGCGCGGCGAGCGCACCAGCAGCATCCTGGCTCAGCCGCGGCGGTGGCGGGGGCGCAACCAGCGGGCCGAGGCGGCGGCGCCAG CGGCGCCTTAAATAGCATCCAGAGCCGGCGCGGGGCAGGGAGTGGGCTGCAGTGACAGCCGGCGGCGGAGCGGCCGGTCCACGGAGGAGA ATTCAGCTTAGAGAACTATCAACACAGGACAATGCAAGCCCATGAGCTGTTCCGGTATTTTCGAATGCCAGAGCTGGTTGACTTCCGACA GTACGTGCGTACTCTTCCGACCAACACGCTTATGGGCTTCGGAGCTTTTGCAGCACTCACCACCTTCTGGTACGCCACGAGACCCAAACC CCTGAAGCCGCCATGCGACCTCTCCATGCAGTCAGTGGAAGTGGCGGGTAGTGGTGGTGCACGAAGATCCGCACTACTTGACAGCGACGA GCCCTTGGTGTATTTCTATGATGATGTCACAACATTATACGAAGGTTTCCAGAGGGGAATACAGGTGTCAAATAATGGCCCTTGTTTAGG CTCTCGGAAACCAGACCAACCCTATGAATGGCTTTCATATAAACAGGTTGCAGAATTGTCGGAGTGCATAGGCTCAGCACTGATCCAGAA GGGCTTCAAGACTGCCCCAGATCAGTTCATTGGCATCTTTGCTCAAAATAGACCTGAGTGGGTGATTATTGAACAAGGATGCTTTGCTTA TTCGATGGTGATCGTTCCACTTTATGATACCCTTGGAAATGAAGCCATCACGTACATAGTCAACAAAGGTAAACCAGGTGAAATGTCAAC TACCTGAAAGTATTTTCCAAGTAGACGAACTCTTGCACCGTCTCAATTTTTTTGTAGAAGTATGCAGAAGGTACTTGTGGAAAATGACTG TGGACGCTTCAGAAAATGTACAATGCTGCGTCATATTCAGTCACTTTCCATTTATCTTTAATAATCTGTCGAAAATTAAACTACTACATA CAGACACACTTTTAAAAATAGAGAGTAAAAAACATAAAGCTTATCTTAGGTCGGCAGCAATTGAGGAAGAAAGAGAGTCTGAATTCGCTT TGAGGCCCACGTTTGATCTAACAGTCAGAAGGAATCACTTGATTGAGGATGTTTTGAATCAGCTAAGTCAATTTGAGAATGAAGACCTGA GGAAAGAGTTATGGGTTTCATTTAGTGGAGAAATTGGGTATGACCTCGGAGGAGTCAAGAAAGAGTTCTTCTACTGTCTGTTTGCAGAGA TGATCCAGCCGGAATATGGGATGTTCATGTATCCTGAAGGGGCTTCCTGCATGTGGTTTCCTGTCAAGCCTAAATTTGAGAAGAAAAGAT ACTTCTTTTTTGGGGTTCTATGTGGACTTTCCCTGTTCAATTGCAATGTTGCCAACCTTCCTTTCCCACTGGCACTGTTTAAGAAACTTT TGGACCAAATGCCATCATTGGAAGACTTGAAAGAACTCAGTCCTGATTTGGGAAAGAATTTGCAAACACTTCTGGATGATGAAGGTGATA ACTTTGAGGAAGTATTTTACATCCATTTTAATGTGCACTGGGACAGAAACGACACAAACTTAATTCCTAATGGAAGTAGCATAACTGTCA ACCAGACTAACAAGAGAGACTATGTTTCTAAGTATATCAATTACATTTTCAACGACTCTGTAAAGGCGGTTTATGAAGAATTTCGGAGAG GATTTTATAAAATGTGCGACGAAGACATTATCAAATTATTCCACCCCGAAGAACTGAAGGATGTGATTGTTGGAAATACAGATTATGATT GGAAAACATTTGAAAAGAATGCACGTTATGAACCAGGATATAACAGTTCACATCCCACCATAGTGATGTTTTGGAAGGCTTTCCACAAAT TGACTCTGGAAGAAAAGAAAAAATTCCTTGTATTTCTTACAGGAACTGACAGACTACAAATGAAAGATTTAAATAATATGAAAATAACAT TTTGCTGTCCTGAAAGTTGGAATGAAAGAGACCCTATAAGAGCACTGACATGTTTCAGTGTCCTCTTCCTCCCTAAATATTCTACAATGG AAACAGTTGAAGAAGCGCTTCAAGAAGCCATCAACAACAACAGAGGATTTGGCTGACCAGCTTGCTTGTCCAACAGCCTTATTTTGTTGT TGTTATCGTTGTTGTTGTTGTTGTTGTTGTTGTTTCTCTACTTTGTTTTGTTTTAGGCTTTTAGCAGCCTGAAGCCATGGTTTTTCATTT CTGTCTCTAGTGATAAGCAGGAAAGAGGGATGAAGAAGAGGGTTTACTGGCCGGTTAGAACCCGTGACTGTATTCTCTCCCTTGGATACC >1493_1493_1_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000281455_HERC5_chr4_89407266_ENST00000264350_length(amino acids)=427AA_BP= MHRLNFFVEVCRRYLWKMTVDASENVQCCVIFSHFPFIFNNLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRR NHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLS LFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSSITVNQTNKRDYVSK YINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLV -------------------------------------------------------------- >1493_1493_2_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000281455_HERC5_chr4_89407266_ENST00000508159_length(transcript)=2270nt_BP=788nt GGGGCCGGCGCGGCGAGCGCACCAGCAGCATCCTGGCTCAGCCGCGGCGGTGGCGGGGGCGCAACCAGCGGGCCGAGGCGGCGGCGCCAG CGGCGCCTTAAATAGCATCCAGAGCCGGCGCGGGGCAGGGAGTGGGCTGCAGTGACAGCCGGCGGCGGAGCGGCCGGTCCACGGAGGAGA ATTCAGCTTAGAGAACTATCAACACAGGACAATGCAAGCCCATGAGCTGTTCCGGTATTTTCGAATGCCAGAGCTGGTTGACTTCCGACA GTACGTGCGTACTCTTCCGACCAACACGCTTATGGGCTTCGGAGCTTTTGCAGCACTCACCACCTTCTGGTACGCCACGAGACCCAAACC CCTGAAGCCGCCATGCGACCTCTCCATGCAGTCAGTGGAAGTGGCGGGTAGTGGTGGTGCACGAAGATCCGCACTACTTGACAGCGACGA GCCCTTGGTGTATTTCTATGATGATGTCACAACATTATACGAAGGTTTCCAGAGGGGAATACAGGTGTCAAATAATGGCCCTTGTTTAGG CTCTCGGAAACCAGACCAACCCTATGAATGGCTTTCATATAAACAGGTTGCAGAATTGTCGGAGTGCATAGGCTCAGCACTGATCCAGAA GGGCTTCAAGACTGCCCCAGATCAGTTCATTGGCATCTTTGCTCAAAATAGACCTGAGTGGGTGATTATTGAACAAGGATGCTTTGCTTA TTCGATGGTGATCGTTCCACTTTATGATACCCTTGGAAATGAAGCCATCACGTACATAGTCAACAAAGGTAAACCAGGTGAAATGTCAAC TACCTGAAAGTATTTTCCAAGTAGACGAACTCTTGCACCGTCTCAATTTTTTTGTAGAAGTATGCAGAAGGTACTTGTGGAAAATGACTG TGGACGCTTCAGAAAATGTACAATGCTGCGTCATATTCAGTCACTTTCCATTTATCTTTAATAATCTGTCGAAAATTAAACTACTACATA CAGACACACTTTTAAAAATAGAGAGTAAAAAACATAAAGCTTATCTTAGGTCGGCAGCAATTGAGGAAGAAAGAGAGTCTGAATTCGCTT TGAGGCCCACGTTTGATCTAACAGTCAGAAGGAATCACTTGATTGAGGATGTTTTGAATCAGCTAAGTCAATTTGAGAATGAAGACCTGA GGAAAGAGTTATGGGTTTCATTTAGTGGAGAAATTGGGTATGACCTCGGAGGAGTCAAGAAAGAGTTCTTCTACTGTCTGTTTGCAGAGA TGATCCAGCCGGAATATGGGATGTTCATGTATCCTGAAGGGGCTTCCTGCATGTGGTTTCCTGTCAAGCCTAAATTTGAGAAGAAAAGAT ACTTCTTTTTTGGGGTTCTATGTGGACTTTCCCTGTTCAATTGCAATGTTGCCAACCTTCCTTTCCCACTGGCACTGTTTAAGAAACTTT TGGACCAAATGCCATCATTGGAAGACTTGAAAGAACTCAGTCCTGATTTGGGAAAGAATTTGCAAACACTTCTGGATGATGAAGGTGATA ACTTTGAGGAAGTATTTTACATCCATTTTAATGTGCACTGGGACAGAAACGACACAAACTTAATTCCTAATGGAAGTAGCATAACTGTCA ACCAGACTAACAAGAGAGACTATGTTTCTAAGTATATCAATTACATTTTCAACGACTCTGTAAAGGCGGTTTATGAAGAATTTCGGAGAG GATTTTATAAAATGTGCGACGAAGACATTATCAAATTATTCCACCCCGAAGAACTGAAGGATGTGATTGTTGGAAATACAGATTATGATT GGAAAACATTTGAAAAGAATGCACGTTATGAACCAGGATATAACAGTTCACATCCCACCATAGTGATGTTTTGGAAGGCTTTCCACAAAT TGACTCTGGAAGAAAAGAAAAAATTCCTTGTATTTCTTACAGGAACTGACAGACTACAAATGAAAGATTTAAATAATATGAAAATAACAT TTTGCTGTCCTGAAAGTTGGAATGAAAGAGACCCTATAAGAGCACTGACATGTTTCAGTGTCCTCTTCCTCCCTAAATATTCTACAATGG AAACAGTTGAAGAAGCGCTTCAAGAAGCCATCAACAACAACAGAGGATTTGGCTGACCAGCTTGCTTGTCCAACAGCCTTATTTTGTTGT TGTTATCGTTGTTGTTGTTGTTGTTGTTGTTGTTTCTCTACTTTGTTTTGTTTTAGGCTTTTAGCAGCCTGAAGCCATGGTTTTTCATTT >1493_1493_2_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000281455_HERC5_chr4_89407266_ENST00000508159_length(amino acids)=427AA_BP= MHRLNFFVEVCRRYLWKMTVDASENVQCCVIFSHFPFIFNNLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRR NHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLS LFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSSITVNQTNKRDYVSK YINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLV -------------------------------------------------------------- >1493_1493_3_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000437665_HERC5_chr4_89407266_ENST00000264350_length(transcript)=2527nt_BP=904nt ATTTATGTGGGTTTGTTTGAGGGCTGCATTCCTAGTGAAGTATTCCATCAAACTGCCATTATTCATCTTGATGAAAGCTTGAGGAACTTT AGAAGGAGAGAAACATCCAGACCACCCGGTTTTTGGTTTCTAAATGACATGAAGAGAATACAATGTTAATAATTCAGCTTAGAGAACTAT CAACACAGGACAATGCAAGCCCATGAGCTGTTCCGGTATTTTCGAATGCCAGAGCTGGTTGACTTCCGACAGTACGTGCGTACTCTTCCG ACCAACACGCTTATGGGCTTCGGAGCTTTTGCAGCACTCACCACCTTCTGGTACGCCACGAGACCCAAACCCCTGAAGCCGCCATGCGAC CTCTCCATGCAGTCAGTGGAAGTGGCGGGTAGTGGTGGTGCACGAAGATCCGCACTACTTGACAGCGACGAGCCCTTGGTGTATTTCTAT GATGATGTCACAACATTATACGAAGGTTTCCAGAGGGGAATACAGGTGTCAAGATCGCTCAGGCCCCTCTGTGTCCACTGTAACTTTCCC AGAGTCGGTCCCAAAGCTCACTGGACCCTCTAGATGTTCCCTGTGGCCCTGGGGGCTCCATGGTCAAATATGTGAGTGTCACATCCTGTA TTTTATGATAATGGCCCTTGTTTAGGCTCTCGGAAACCAGACCAACCCTATGAATGGCTTTCATATAAACAGGTTGCAGAATTGTCGGAG TGCATAGGCTCAGCACTGATCCAGAAGGGCTTCAAGACTGCCCCAGATCAGTTCATTGGCATCTTTGCTCAAAATAGACCTGAGTGGGTG ATTATTGAACAAGGATGCTTTGCTTATTCGATGGTGATCGTTCCACTTTATGATACCCTTGGAAATGAAGCCATCACGTACATAGTCAAC AAAGGTAAACCAGGTGAAATGTCAACTACCTGAAAGTATTTTCCAAGTAGACGAACTCTTGCACCGTCTCAATTTTTTTGTAGAAGTATG CAGAAGGTACTTGTGGAAAATGACTGTGGACGCTTCAGAAAATGTACAATGCTGCGTCATATTCAGTCACTTTCCATTTATCTTTAATAA TCTGTCGAAAATTAAACTACTACATACAGACACACTTTTAAAAATAGAGAGTAAAAAACATAAAGCTTATCTTAGGTCGGCAGCAATTGA GGAAGAAAGAGAGTCTGAATTCGCTTTGAGGCCCACGTTTGATCTAACAGTCAGAAGGAATCACTTGATTGAGGATGTTTTGAATCAGCT AAGTCAATTTGAGAATGAAGACCTGAGGAAAGAGTTATGGGTTTCATTTAGTGGAGAAATTGGGTATGACCTCGGAGGAGTCAAGAAAGA GTTCTTCTACTGTCTGTTTGCAGAGATGATCCAGCCGGAATATGGGATGTTCATGTATCCTGAAGGGGCTTCCTGCATGTGGTTTCCTGT CAAGCCTAAATTTGAGAAGAAAAGATACTTCTTTTTTGGGGTTCTATGTGGACTTTCCCTGTTCAATTGCAATGTTGCCAACCTTCCTTT CCCACTGGCACTGTTTAAGAAACTTTTGGACCAAATGCCATCATTGGAAGACTTGAAAGAACTCAGTCCTGATTTGGGAAAGAATTTGCA AACACTTCTGGATGATGAAGGTGATAACTTTGAGGAAGTATTTTACATCCATTTTAATGTGCACTGGGACAGAAACGACACAAACTTAAT TCCTAATGGAAGTAGCATAACTGTCAACCAGACTAACAAGAGAGACTATGTTTCTAAGTATATCAATTACATTTTCAACGACTCTGTAAA GGCGGTTTATGAAGAATTTCGGAGAGGATTTTATAAAATGTGCGACGAAGACATTATCAAATTATTCCACCCCGAAGAACTGAAGGATGT GATTGTTGGAAATACAGATTATGATTGGAAAACATTTGAAAAGAATGCACGTTATGAACCAGGATATAACAGTTCACATCCCACCATAGT GATGTTTTGGAAGGCTTTCCACAAATTGACTCTGGAAGAAAAGAAAAAATTCCTTGTATTTCTTACAGGAACTGACAGACTACAAATGAA AGATTTAAATAATATGAAAATAACATTTTGCTGTCCTGAAAGTTGGAATGAAAGAGACCCTATAAGAGCACTGACATGTTTCAGTGTCCT CTTCCTCCCTAAATATTCTACAATGGAAACAGTTGAAGAAGCGCTTCAAGAAGCCATCAACAACAACAGAGGATTTGGCTGACCAGCTTG CTTGTCCAACAGCCTTATTTTGTTGTTGTTATCGTTGTTGTTGTTGTTGTTGTTGTTGTTTCTCTACTTTGTTTTGTTTTAGGCTTTTAG CAGCCTGAAGCCATGGTTTTTCATTTCTGTCTCTAGTGATAAGCAGGAAAGAGGGATGAAGAAGAGGGTTTACTGGCCGGTTAGAACCCG TGACTGTATTCTCTCCCTTGGATACCCCTATGCCTACATCATATTCCTTACCTCTTTTGGGAAATATTTTTCAAAAATAAAATAACCGAA >1493_1493_3_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000437665_HERC5_chr4_89407266_ENST00000264350_length(amino acids)=427AA_BP= MHRLNFFVEVCRRYLWKMTVDASENVQCCVIFSHFPFIFNNLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRR NHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLS LFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSSITVNQTNKRDYVSK YINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLV -------------------------------------------------------------- >1493_1493_4_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000437665_HERC5_chr4_89407266_ENST00000508159_length(transcript)=2386nt_BP=904nt ATTTATGTGGGTTTGTTTGAGGGCTGCATTCCTAGTGAAGTATTCCATCAAACTGCCATTATTCATCTTGATGAAAGCTTGAGGAACTTT AGAAGGAGAGAAACATCCAGACCACCCGGTTTTTGGTTTCTAAATGACATGAAGAGAATACAATGTTAATAATTCAGCTTAGAGAACTAT CAACACAGGACAATGCAAGCCCATGAGCTGTTCCGGTATTTTCGAATGCCAGAGCTGGTTGACTTCCGACAGTACGTGCGTACTCTTCCG ACCAACACGCTTATGGGCTTCGGAGCTTTTGCAGCACTCACCACCTTCTGGTACGCCACGAGACCCAAACCCCTGAAGCCGCCATGCGAC CTCTCCATGCAGTCAGTGGAAGTGGCGGGTAGTGGTGGTGCACGAAGATCCGCACTACTTGACAGCGACGAGCCCTTGGTGTATTTCTAT GATGATGTCACAACATTATACGAAGGTTTCCAGAGGGGAATACAGGTGTCAAGATCGCTCAGGCCCCTCTGTGTCCACTGTAACTTTCCC AGAGTCGGTCCCAAAGCTCACTGGACCCTCTAGATGTTCCCTGTGGCCCTGGGGGCTCCATGGTCAAATATGTGAGTGTCACATCCTGTA TTTTATGATAATGGCCCTTGTTTAGGCTCTCGGAAACCAGACCAACCCTATGAATGGCTTTCATATAAACAGGTTGCAGAATTGTCGGAG TGCATAGGCTCAGCACTGATCCAGAAGGGCTTCAAGACTGCCCCAGATCAGTTCATTGGCATCTTTGCTCAAAATAGACCTGAGTGGGTG ATTATTGAACAAGGATGCTTTGCTTATTCGATGGTGATCGTTCCACTTTATGATACCCTTGGAAATGAAGCCATCACGTACATAGTCAAC AAAGGTAAACCAGGTGAAATGTCAACTACCTGAAAGTATTTTCCAAGTAGACGAACTCTTGCACCGTCTCAATTTTTTTGTAGAAGTATG CAGAAGGTACTTGTGGAAAATGACTGTGGACGCTTCAGAAAATGTACAATGCTGCGTCATATTCAGTCACTTTCCATTTATCTTTAATAA TCTGTCGAAAATTAAACTACTACATACAGACACACTTTTAAAAATAGAGAGTAAAAAACATAAAGCTTATCTTAGGTCGGCAGCAATTGA GGAAGAAAGAGAGTCTGAATTCGCTTTGAGGCCCACGTTTGATCTAACAGTCAGAAGGAATCACTTGATTGAGGATGTTTTGAATCAGCT AAGTCAATTTGAGAATGAAGACCTGAGGAAAGAGTTATGGGTTTCATTTAGTGGAGAAATTGGGTATGACCTCGGAGGAGTCAAGAAAGA GTTCTTCTACTGTCTGTTTGCAGAGATGATCCAGCCGGAATATGGGATGTTCATGTATCCTGAAGGGGCTTCCTGCATGTGGTTTCCTGT CAAGCCTAAATTTGAGAAGAAAAGATACTTCTTTTTTGGGGTTCTATGTGGACTTTCCCTGTTCAATTGCAATGTTGCCAACCTTCCTTT CCCACTGGCACTGTTTAAGAAACTTTTGGACCAAATGCCATCATTGGAAGACTTGAAAGAACTCAGTCCTGATTTGGGAAAGAATTTGCA AACACTTCTGGATGATGAAGGTGATAACTTTGAGGAAGTATTTTACATCCATTTTAATGTGCACTGGGACAGAAACGACACAAACTTAAT TCCTAATGGAAGTAGCATAACTGTCAACCAGACTAACAAGAGAGACTATGTTTCTAAGTATATCAATTACATTTTCAACGACTCTGTAAA GGCGGTTTATGAAGAATTTCGGAGAGGATTTTATAAAATGTGCGACGAAGACATTATCAAATTATTCCACCCCGAAGAACTGAAGGATGT GATTGTTGGAAATACAGATTATGATTGGAAAACATTTGAAAAGAATGCACGTTATGAACCAGGATATAACAGTTCACATCCCACCATAGT GATGTTTTGGAAGGCTTTCCACAAATTGACTCTGGAAGAAAAGAAAAAATTCCTTGTATTTCTTACAGGAACTGACAGACTACAAATGAA AGATTTAAATAATATGAAAATAACATTTTGCTGTCCTGAAAGTTGGAATGAAAGAGACCCTATAAGAGCACTGACATGTTTCAGTGTCCT CTTCCTCCCTAAATATTCTACAATGGAAACAGTTGAAGAAGCGCTTCAAGAAGCCATCAACAACAACAGAGGATTTGGCTGACCAGCTTG CTTGTCCAACAGCCTTATTTTGTTGTTGTTATCGTTGTTGTTGTTGTTGTTGTTGTTGTTTCTCTACTTTGTTTTGTTTTAGGCTTTTAG >1493_1493_4_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000437665_HERC5_chr4_89407266_ENST00000508159_length(amino acids)=427AA_BP= MHRLNFFVEVCRRYLWKMTVDASENVQCCVIFSHFPFIFNNLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRR NHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLS LFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSSITVNQTNKRDYVSK YINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLV -------------------------------------------------------------- >1493_1493_5_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000504900_HERC5_chr4_89407266_ENST00000264350_length(transcript)=2369nt_BP=746nt CGCGGCGGTGGCGGGGGCGCAACCAGCGGGCCGAGGCGGCGGCGCCAGCGGCGCCTTAAATAGCATCCAGAGCCGGCGCGGGGCAGGGAG TGGGCTGCAGTGACAGCCGGCGGCGGAGCGGCCGGTCCACGGAGGAGAATTCAGCTTAGAGAACTATCAACACAGGACAATGCAAGCCCA TGAGCTGTTCCGGTATTTTCGAATGCCAGAGCTGGTTGACTTCCGACAGTACGTGCGTACTCTTCCGACCAACACGCTTATGGGCTTCGG AGCTTTTGCAGCACTCACCACCTTCTGGTACGCCACGAGACCCAAACCCCTGAAGCCGCCATGCGACCTCTCCATGCAGTCAGTGGAAGT GGCGGGTAGTGGTGGTGCACGAAGATCCGCACTACTTGACAGCGACGAGCCCTTGGTGTATTTCTATGATGATGTCACAACATTATACGA AGGTTTCCAGAGGGGAATACAGGTGTCAAATAATGGCCCTTGTTTAGGCTCTCGGAAACCAGACCAACCCTATGAATGGCTTTCATATAA ACAGGTTGCAGAATTGTCGGAGTGCATAGGCTCAGCACTGATCCAGAAGGGCTTCAAGACTGCCCCAGATCAGTTCATTGGCATCTTTGC TCAAAATAGACCTGAGTGGGTGATTATTGAACAAGGATGCTTTGCTTATTCGATGGTGATCGTTCCACTTTATGATACCCTTGGAAATGA AGCCATCACGTACATAGTCAACAAAGGTAAACCAGGTGAAATGTCAACTACCTGAAAGTATTTTCCAAGTAGACGAACTCTTGCACCGTC TCAATTTTTTTGTAGAAGTATGCAGAAGGTACTTGTGGAAAATGACTGTGGACGCTTCAGAAAATGTACAATGCTGCGTCATATTCAGTC ACTTTCCATTTATCTTTAATAATCTGTCGAAAATTAAACTACTACATACAGACACACTTTTAAAAATAGAGAGTAAAAAACATAAAGCTT ATCTTAGGTCGGCAGCAATTGAGGAAGAAAGAGAGTCTGAATTCGCTTTGAGGCCCACGTTTGATCTAACAGTCAGAAGGAATCACTTGA TTGAGGATGTTTTGAATCAGCTAAGTCAATTTGAGAATGAAGACCTGAGGAAAGAGTTATGGGTTTCATTTAGTGGAGAAATTGGGTATG ACCTCGGAGGAGTCAAGAAAGAGTTCTTCTACTGTCTGTTTGCAGAGATGATCCAGCCGGAATATGGGATGTTCATGTATCCTGAAGGGG CTTCCTGCATGTGGTTTCCTGTCAAGCCTAAATTTGAGAAGAAAAGATACTTCTTTTTTGGGGTTCTATGTGGACTTTCCCTGTTCAATT GCAATGTTGCCAACCTTCCTTTCCCACTGGCACTGTTTAAGAAACTTTTGGACCAAATGCCATCATTGGAAGACTTGAAAGAACTCAGTC CTGATTTGGGAAAGAATTTGCAAACACTTCTGGATGATGAAGGTGATAACTTTGAGGAAGTATTTTACATCCATTTTAATGTGCACTGGG ACAGAAACGACACAAACTTAATTCCTAATGGAAGTAGCATAACTGTCAACCAGACTAACAAGAGAGACTATGTTTCTAAGTATATCAATT ACATTTTCAACGACTCTGTAAAGGCGGTTTATGAAGAATTTCGGAGAGGATTTTATAAAATGTGCGACGAAGACATTATCAAATTATTCC ACCCCGAAGAACTGAAGGATGTGATTGTTGGAAATACAGATTATGATTGGAAAACATTTGAAAAGAATGCACGTTATGAACCAGGATATA ACAGTTCACATCCCACCATAGTGATGTTTTGGAAGGCTTTCCACAAATTGACTCTGGAAGAAAAGAAAAAATTCCTTGTATTTCTTACAG GAACTGACAGACTACAAATGAAAGATTTAAATAATATGAAAATAACATTTTGCTGTCCTGAAAGTTGGAATGAAAGAGACCCTATAAGAG CACTGACATGTTTCAGTGTCCTCTTCCTCCCTAAATATTCTACAATGGAAACAGTTGAAGAAGCGCTTCAAGAAGCCATCAACAACAACA GAGGATTTGGCTGACCAGCTTGCTTGTCCAACAGCCTTATTTTGTTGTTGTTATCGTTGTTGTTGTTGTTGTTGTTGTTGTTTCTCTACT TTGTTTTGTTTTAGGCTTTTAGCAGCCTGAAGCCATGGTTTTTCATTTCTGTCTCTAGTGATAAGCAGGAAAGAGGGATGAAGAAGAGGG TTTACTGGCCGGTTAGAACCCGTGACTGTATTCTCTCCCTTGGATACCCCTATGCCTACATCATATTCCTTACCTCTTTTGGGAAATATT >1493_1493_5_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000504900_HERC5_chr4_89407266_ENST00000264350_length(amino acids)=427AA_BP= MHRLNFFVEVCRRYLWKMTVDASENVQCCVIFSHFPFIFNNLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRR NHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLS LFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSSITVNQTNKRDYVSK YINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLV -------------------------------------------------------------- >1493_1493_6_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000504900_HERC5_chr4_89407266_ENST00000508159_length(transcript)=2228nt_BP=746nt CGCGGCGGTGGCGGGGGCGCAACCAGCGGGCCGAGGCGGCGGCGCCAGCGGCGCCTTAAATAGCATCCAGAGCCGGCGCGGGGCAGGGAG TGGGCTGCAGTGACAGCCGGCGGCGGAGCGGCCGGTCCACGGAGGAGAATTCAGCTTAGAGAACTATCAACACAGGACAATGCAAGCCCA TGAGCTGTTCCGGTATTTTCGAATGCCAGAGCTGGTTGACTTCCGACAGTACGTGCGTACTCTTCCGACCAACACGCTTATGGGCTTCGG AGCTTTTGCAGCACTCACCACCTTCTGGTACGCCACGAGACCCAAACCCCTGAAGCCGCCATGCGACCTCTCCATGCAGTCAGTGGAAGT GGCGGGTAGTGGTGGTGCACGAAGATCCGCACTACTTGACAGCGACGAGCCCTTGGTGTATTTCTATGATGATGTCACAACATTATACGA AGGTTTCCAGAGGGGAATACAGGTGTCAAATAATGGCCCTTGTTTAGGCTCTCGGAAACCAGACCAACCCTATGAATGGCTTTCATATAA ACAGGTTGCAGAATTGTCGGAGTGCATAGGCTCAGCACTGATCCAGAAGGGCTTCAAGACTGCCCCAGATCAGTTCATTGGCATCTTTGC TCAAAATAGACCTGAGTGGGTGATTATTGAACAAGGATGCTTTGCTTATTCGATGGTGATCGTTCCACTTTATGATACCCTTGGAAATGA AGCCATCACGTACATAGTCAACAAAGGTAAACCAGGTGAAATGTCAACTACCTGAAAGTATTTTCCAAGTAGACGAACTCTTGCACCGTC TCAATTTTTTTGTAGAAGTATGCAGAAGGTACTTGTGGAAAATGACTGTGGACGCTTCAGAAAATGTACAATGCTGCGTCATATTCAGTC ACTTTCCATTTATCTTTAATAATCTGTCGAAAATTAAACTACTACATACAGACACACTTTTAAAAATAGAGAGTAAAAAACATAAAGCTT ATCTTAGGTCGGCAGCAATTGAGGAAGAAAGAGAGTCTGAATTCGCTTTGAGGCCCACGTTTGATCTAACAGTCAGAAGGAATCACTTGA TTGAGGATGTTTTGAATCAGCTAAGTCAATTTGAGAATGAAGACCTGAGGAAAGAGTTATGGGTTTCATTTAGTGGAGAAATTGGGTATG ACCTCGGAGGAGTCAAGAAAGAGTTCTTCTACTGTCTGTTTGCAGAGATGATCCAGCCGGAATATGGGATGTTCATGTATCCTGAAGGGG CTTCCTGCATGTGGTTTCCTGTCAAGCCTAAATTTGAGAAGAAAAGATACTTCTTTTTTGGGGTTCTATGTGGACTTTCCCTGTTCAATT GCAATGTTGCCAACCTTCCTTTCCCACTGGCACTGTTTAAGAAACTTTTGGACCAAATGCCATCATTGGAAGACTTGAAAGAACTCAGTC CTGATTTGGGAAAGAATTTGCAAACACTTCTGGATGATGAAGGTGATAACTTTGAGGAAGTATTTTACATCCATTTTAATGTGCACTGGG ACAGAAACGACACAAACTTAATTCCTAATGGAAGTAGCATAACTGTCAACCAGACTAACAAGAGAGACTATGTTTCTAAGTATATCAATT ACATTTTCAACGACTCTGTAAAGGCGGTTTATGAAGAATTTCGGAGAGGATTTTATAAAATGTGCGACGAAGACATTATCAAATTATTCC ACCCCGAAGAACTGAAGGATGTGATTGTTGGAAATACAGATTATGATTGGAAAACATTTGAAAAGAATGCACGTTATGAACCAGGATATA ACAGTTCACATCCCACCATAGTGATGTTTTGGAAGGCTTTCCACAAATTGACTCTGGAAGAAAAGAAAAAATTCCTTGTATTTCTTACAG GAACTGACAGACTACAAATGAAAGATTTAAATAATATGAAAATAACATTTTGCTGTCCTGAAAGTTGGAATGAAAGAGACCCTATAAGAG CACTGACATGTTTCAGTGTCCTCTTCCTCCCTAAATATTCTACAATGGAAACAGTTGAAGAAGCGCTTCAAGAAGCCATCAACAACAACA GAGGATTTGGCTGACCAGCTTGCTTGTCCAACAGCCTTATTTTGTTGTTGTTATCGTTGTTGTTGTTGTTGTTGTTGTTGTTTCTCTACT >1493_1493_6_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000504900_HERC5_chr4_89407266_ENST00000508159_length(amino acids)=427AA_BP= MHRLNFFVEVCRRYLWKMTVDASENVQCCVIFSHFPFIFNNLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRR NHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLS LFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSSITVNQTNKRDYVSK YINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLV -------------------------------------------------------------- >1493_1493_7_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000507295_HERC5_chr4_89407266_ENST00000264350_length(transcript)=2249nt_BP=626nt GCAACCAGCGGGCCGAGGCGGCGGCGCCAGCGGCGCCTTAAATAGCATCCAGAGCCGGCGCGGGGCAGGGAGTGGGCTGCAGTGACAGCC GGCGGCGGAGCGGCCGGTCCACGGAGGAGAATTCAGCTTAGAGAACTATCAACACAGGACAATGCAAGCCCATGAGCTGTTCCGGTATTT TCGAATGCCAGAGCTGGTTGACTTCCGACAGTACGTGCGTACTCTTCCGACCAACACGCTTATGGGCTTCGGAGCTTTTGCAGCACTCAC CACCTTCTGGTACGCCACGAGACCCAAACCCCTGAAGCCGCCATGCGACCTCTCCATGCAGTCAGTGGAAGTGGCGGGTAGTGGTGGTGC ACGAAGATCCGCACTACTTGACAGCGACGAGCCCTTGGTGTATTTCTATGATGATGTCACAACATTATACGAAGGTTTCCAGAGGGGAAT ACAGGTGTCAAATAATGGCCCTTGTTTAGGCTCTCGGAAACCAGACCAACCCTATGAATGGCTTTCATATAAACAGTGGGTGATTATTGA ACAAGGATGCTTTGCTTATTCGATGGTGATCGTTCCACTTTATGATACCCTTGGAAATGAAGCCATCACGTACATAGTCAACAAAGGTAA ACCAGGTGAAATGTCAACTACCTGAAAGTATTTTCCAAGTAGACGAACTCTTGCACCGTCTCAATTTTTTTGTAGAAGTATGCAGAAGGT ACTTGTGGAAAATGACTGTGGACGCTTCAGAAAATGTACAATGCTGCGTCATATTCAGTCACTTTCCATTTATCTTTAATAATCTGTCGA AAATTAAACTACTACATACAGACACACTTTTAAAAATAGAGAGTAAAAAACATAAAGCTTATCTTAGGTCGGCAGCAATTGAGGAAGAAA GAGAGTCTGAATTCGCTTTGAGGCCCACGTTTGATCTAACAGTCAGAAGGAATCACTTGATTGAGGATGTTTTGAATCAGCTAAGTCAAT TTGAGAATGAAGACCTGAGGAAAGAGTTATGGGTTTCATTTAGTGGAGAAATTGGGTATGACCTCGGAGGAGTCAAGAAAGAGTTCTTCT ACTGTCTGTTTGCAGAGATGATCCAGCCGGAATATGGGATGTTCATGTATCCTGAAGGGGCTTCCTGCATGTGGTTTCCTGTCAAGCCTA AATTTGAGAAGAAAAGATACTTCTTTTTTGGGGTTCTATGTGGACTTTCCCTGTTCAATTGCAATGTTGCCAACCTTCCTTTCCCACTGG CACTGTTTAAGAAACTTTTGGACCAAATGCCATCATTGGAAGACTTGAAAGAACTCAGTCCTGATTTGGGAAAGAATTTGCAAACACTTC TGGATGATGAAGGTGATAACTTTGAGGAAGTATTTTACATCCATTTTAATGTGCACTGGGACAGAAACGACACAAACTTAATTCCTAATG GAAGTAGCATAACTGTCAACCAGACTAACAAGAGAGACTATGTTTCTAAGTATATCAATTACATTTTCAACGACTCTGTAAAGGCGGTTT ATGAAGAATTTCGGAGAGGATTTTATAAAATGTGCGACGAAGACATTATCAAATTATTCCACCCCGAAGAACTGAAGGATGTGATTGTTG GAAATACAGATTATGATTGGAAAACATTTGAAAAGAATGCACGTTATGAACCAGGATATAACAGTTCACATCCCACCATAGTGATGTTTT GGAAGGCTTTCCACAAATTGACTCTGGAAGAAAAGAAAAAATTCCTTGTATTTCTTACAGGAACTGACAGACTACAAATGAAAGATTTAA ATAATATGAAAATAACATTTTGCTGTCCTGAAAGTTGGAATGAAAGAGACCCTATAAGAGCACTGACATGTTTCAGTGTCCTCTTCCTCC CTAAATATTCTACAATGGAAACAGTTGAAGAAGCGCTTCAAGAAGCCATCAACAACAACAGAGGATTTGGCTGACCAGCTTGCTTGTCCA ACAGCCTTATTTTGTTGTTGTTATCGTTGTTGTTGTTGTTGTTGTTGTTGTTTCTCTACTTTGTTTTGTTTTAGGCTTTTAGCAGCCTGA AGCCATGGTTTTTCATTTCTGTCTCTAGTGATAAGCAGGAAAGAGGGATGAAGAAGAGGGTTTACTGGCCGGTTAGAACCCGTGACTGTA >1493_1493_7_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000507295_HERC5_chr4_89407266_ENST00000264350_length(amino acids)=427AA_BP= MHRLNFFVEVCRRYLWKMTVDASENVQCCVIFSHFPFIFNNLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRR NHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLS LFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSSITVNQTNKRDYVSK YINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLV -------------------------------------------------------------- >1493_1493_8_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000507295_HERC5_chr4_89407266_ENST00000508159_length(transcript)=2108nt_BP=626nt GCAACCAGCGGGCCGAGGCGGCGGCGCCAGCGGCGCCTTAAATAGCATCCAGAGCCGGCGCGGGGCAGGGAGTGGGCTGCAGTGACAGCC GGCGGCGGAGCGGCCGGTCCACGGAGGAGAATTCAGCTTAGAGAACTATCAACACAGGACAATGCAAGCCCATGAGCTGTTCCGGTATTT TCGAATGCCAGAGCTGGTTGACTTCCGACAGTACGTGCGTACTCTTCCGACCAACACGCTTATGGGCTTCGGAGCTTTTGCAGCACTCAC CACCTTCTGGTACGCCACGAGACCCAAACCCCTGAAGCCGCCATGCGACCTCTCCATGCAGTCAGTGGAAGTGGCGGGTAGTGGTGGTGC ACGAAGATCCGCACTACTTGACAGCGACGAGCCCTTGGTGTATTTCTATGATGATGTCACAACATTATACGAAGGTTTCCAGAGGGGAAT ACAGGTGTCAAATAATGGCCCTTGTTTAGGCTCTCGGAAACCAGACCAACCCTATGAATGGCTTTCATATAAACAGTGGGTGATTATTGA ACAAGGATGCTTTGCTTATTCGATGGTGATCGTTCCACTTTATGATACCCTTGGAAATGAAGCCATCACGTACATAGTCAACAAAGGTAA ACCAGGTGAAATGTCAACTACCTGAAAGTATTTTCCAAGTAGACGAACTCTTGCACCGTCTCAATTTTTTTGTAGAAGTATGCAGAAGGT ACTTGTGGAAAATGACTGTGGACGCTTCAGAAAATGTACAATGCTGCGTCATATTCAGTCACTTTCCATTTATCTTTAATAATCTGTCGA AAATTAAACTACTACATACAGACACACTTTTAAAAATAGAGAGTAAAAAACATAAAGCTTATCTTAGGTCGGCAGCAATTGAGGAAGAAA GAGAGTCTGAATTCGCTTTGAGGCCCACGTTTGATCTAACAGTCAGAAGGAATCACTTGATTGAGGATGTTTTGAATCAGCTAAGTCAAT TTGAGAATGAAGACCTGAGGAAAGAGTTATGGGTTTCATTTAGTGGAGAAATTGGGTATGACCTCGGAGGAGTCAAGAAAGAGTTCTTCT ACTGTCTGTTTGCAGAGATGATCCAGCCGGAATATGGGATGTTCATGTATCCTGAAGGGGCTTCCTGCATGTGGTTTCCTGTCAAGCCTA AATTTGAGAAGAAAAGATACTTCTTTTTTGGGGTTCTATGTGGACTTTCCCTGTTCAATTGCAATGTTGCCAACCTTCCTTTCCCACTGG CACTGTTTAAGAAACTTTTGGACCAAATGCCATCATTGGAAGACTTGAAAGAACTCAGTCCTGATTTGGGAAAGAATTTGCAAACACTTC TGGATGATGAAGGTGATAACTTTGAGGAAGTATTTTACATCCATTTTAATGTGCACTGGGACAGAAACGACACAAACTTAATTCCTAATG GAAGTAGCATAACTGTCAACCAGACTAACAAGAGAGACTATGTTTCTAAGTATATCAATTACATTTTCAACGACTCTGTAAAGGCGGTTT ATGAAGAATTTCGGAGAGGATTTTATAAAATGTGCGACGAAGACATTATCAAATTATTCCACCCCGAAGAACTGAAGGATGTGATTGTTG GAAATACAGATTATGATTGGAAAACATTTGAAAAGAATGCACGTTATGAACCAGGATATAACAGTTCACATCCCACCATAGTGATGTTTT GGAAGGCTTTCCACAAATTGACTCTGGAAGAAAAGAAAAAATTCCTTGTATTTCTTACAGGAACTGACAGACTACAAATGAAAGATTTAA ATAATATGAAAATAACATTTTGCTGTCCTGAAAGTTGGAATGAAAGAGACCCTATAAGAGCACTGACATGTTTCAGTGTCCTCTTCCTCC CTAAATATTCTACAATGGAAACAGTTGAAGAAGCGCTTCAAGAAGCCATCAACAACAACAGAGGATTTGGCTGACCAGCTTGCTTGTCCA ACAGCCTTATTTTGTTGTTGTTATCGTTGTTGTTGTTGTTGTTGTTGTTGTTTCTCTACTTTGTTTTGTTTTAGGCTTTTAGCAGCCTGA >1493_1493_8_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000507295_HERC5_chr4_89407266_ENST00000508159_length(amino acids)=427AA_BP= MHRLNFFVEVCRRYLWKMTVDASENVQCCVIFSHFPFIFNNLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRR NHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLS LFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSSITVNQTNKRDYVSK YINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLV -------------------------------------------------------------- >1493_1493_9_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000515030_HERC5_chr4_89407266_ENST00000264350_length(transcript)=2526nt_BP=903nt AAACTCCACGGTAACGGGGACCAATGTTGTTAGAGGTTGAGGTTCCTGGTAGGTCCCAGGTGCTAAAAGGAAGAGCAGCCTTTGGGATGT GAGCCCGAAAACCATCGTGTTGGCTTCTGAAGCCCCAAGATGGGCATGGCAGGGACGCGGAAGCCCTCAGAACCGCGGAAGCCCTCAGAA CCGCACAGCAGGTGGCCGCCGTGGTGCAGCGCGCAGTCGGCCCTCAGCTCCCCTGCACCGGCGCGAGCTGCGGGCGCTGCCCACGTCAGG CTCTGCAGACACCAGACAGAAAAGAATTCAGCTTAGAGAACTATCAACACAGGACAATGCAAGCCCATGAGCTGTTCCGGTATTTTCGAA TGCCAGAGCTGGTTGACTTCCGACAGTACGTGCGTACTCTTCCGACCAACACGCTTATGGGCTTCGGAGCTTTTGCAGCACTCACCACCT TCTGGTACGCCACGAGACCCAAACCCCTGAAGCCGCCATGCGACCTCTCCATGCAGTCAGTGGAAGTGGCGGGTAGTGGTGGTGCACGAA GATCCGCACTACTTGACAGCGACGAGCCCTTGGTGTATTTCTATGATGATGTCACAACATTATACGAAGGTTTCCAGAGGGGAATACAGG TGTCAAATAATGGCCCTTGTTTAGGCTCTCGGAAACCAGACCAACCCTATGAATGGCTTTCATATAAACAGGTTGCAGAATTGTCGGAGT GCATAGGCTCAGCACTGATCCAGAAGGGCTTCAAGACTGCCCCAGATCAGTTCATTGGCATCTTTGCTCAAAATAGACCTGAGTGGGTGA TTATTGAACAAGGATGCTTTGCTTATTCGATGGTGATCGTTCCACTTTATGATACCCTTGGAAATGAAGCCATCACGTACATAGTCAACA AAGGTAAACCAGGTGAAATGTCAACTACCTGAAAGTATTTTCCAAGTAGACGAACTCTTGCACCGTCTCAATTTTTTTGTAGAAGTATGC AGAAGGTACTTGTGGAAAATGACTGTGGACGCTTCAGAAAATGTACAATGCTGCGTCATATTCAGTCACTTTCCATTTATCTTTAATAAT CTGTCGAAAATTAAACTACTACATACAGACACACTTTTAAAAATAGAGAGTAAAAAACATAAAGCTTATCTTAGGTCGGCAGCAATTGAG GAAGAAAGAGAGTCTGAATTCGCTTTGAGGCCCACGTTTGATCTAACAGTCAGAAGGAATCACTTGATTGAGGATGTTTTGAATCAGCTA AGTCAATTTGAGAATGAAGACCTGAGGAAAGAGTTATGGGTTTCATTTAGTGGAGAAATTGGGTATGACCTCGGAGGAGTCAAGAAAGAG TTCTTCTACTGTCTGTTTGCAGAGATGATCCAGCCGGAATATGGGATGTTCATGTATCCTGAAGGGGCTTCCTGCATGTGGTTTCCTGTC AAGCCTAAATTTGAGAAGAAAAGATACTTCTTTTTTGGGGTTCTATGTGGACTTTCCCTGTTCAATTGCAATGTTGCCAACCTTCCTTTC CCACTGGCACTGTTTAAGAAACTTTTGGACCAAATGCCATCATTGGAAGACTTGAAAGAACTCAGTCCTGATTTGGGAAAGAATTTGCAA ACACTTCTGGATGATGAAGGTGATAACTTTGAGGAAGTATTTTACATCCATTTTAATGTGCACTGGGACAGAAACGACACAAACTTAATT CCTAATGGAAGTAGCATAACTGTCAACCAGACTAACAAGAGAGACTATGTTTCTAAGTATATCAATTACATTTTCAACGACTCTGTAAAG GCGGTTTATGAAGAATTTCGGAGAGGATTTTATAAAATGTGCGACGAAGACATTATCAAATTATTCCACCCCGAAGAACTGAAGGATGTG ATTGTTGGAAATACAGATTATGATTGGAAAACATTTGAAAAGAATGCACGTTATGAACCAGGATATAACAGTTCACATCCCACCATAGTG ATGTTTTGGAAGGCTTTCCACAAATTGACTCTGGAAGAAAAGAAAAAATTCCTTGTATTTCTTACAGGAACTGACAGACTACAAATGAAA GATTTAAATAATATGAAAATAACATTTTGCTGTCCTGAAAGTTGGAATGAAAGAGACCCTATAAGAGCACTGACATGTTTCAGTGTCCTC TTCCTCCCTAAATATTCTACAATGGAAACAGTTGAAGAAGCGCTTCAAGAAGCCATCAACAACAACAGAGGATTTGGCTGACCAGCTTGC TTGTCCAACAGCCTTATTTTGTTGTTGTTATCGTTGTTGTTGTTGTTGTTGTTGTTGTTTCTCTACTTTGTTTTGTTTTAGGCTTTTAGC AGCCTGAAGCCATGGTTTTTCATTTCTGTCTCTAGTGATAAGCAGGAAAGAGGGATGAAGAAGAGGGTTTACTGGCCGGTTAGAACCCGT GACTGTATTCTCTCCCTTGGATACCCCTATGCCTACATCATATTCCTTACCTCTTTTGGGAAATATTTTTCAAAAATAAAATAACCGAAA >1493_1493_9_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000515030_HERC5_chr4_89407266_ENST00000264350_length(amino acids)=427AA_BP= MHRLNFFVEVCRRYLWKMTVDASENVQCCVIFSHFPFIFNNLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRR NHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLS LFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSSITVNQTNKRDYVSK YINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLV -------------------------------------------------------------- >1493_1493_10_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000515030_HERC5_chr4_89407266_ENST00000508159_length(transcript)=2385nt_BP=903nt AAACTCCACGGTAACGGGGACCAATGTTGTTAGAGGTTGAGGTTCCTGGTAGGTCCCAGGTGCTAAAAGGAAGAGCAGCCTTTGGGATGT GAGCCCGAAAACCATCGTGTTGGCTTCTGAAGCCCCAAGATGGGCATGGCAGGGACGCGGAAGCCCTCAGAACCGCGGAAGCCCTCAGAA CCGCACAGCAGGTGGCCGCCGTGGTGCAGCGCGCAGTCGGCCCTCAGCTCCCCTGCACCGGCGCGAGCTGCGGGCGCTGCCCACGTCAGG CTCTGCAGACACCAGACAGAAAAGAATTCAGCTTAGAGAACTATCAACACAGGACAATGCAAGCCCATGAGCTGTTCCGGTATTTTCGAA TGCCAGAGCTGGTTGACTTCCGACAGTACGTGCGTACTCTTCCGACCAACACGCTTATGGGCTTCGGAGCTTTTGCAGCACTCACCACCT TCTGGTACGCCACGAGACCCAAACCCCTGAAGCCGCCATGCGACCTCTCCATGCAGTCAGTGGAAGTGGCGGGTAGTGGTGGTGCACGAA GATCCGCACTACTTGACAGCGACGAGCCCTTGGTGTATTTCTATGATGATGTCACAACATTATACGAAGGTTTCCAGAGGGGAATACAGG TGTCAAATAATGGCCCTTGTTTAGGCTCTCGGAAACCAGACCAACCCTATGAATGGCTTTCATATAAACAGGTTGCAGAATTGTCGGAGT GCATAGGCTCAGCACTGATCCAGAAGGGCTTCAAGACTGCCCCAGATCAGTTCATTGGCATCTTTGCTCAAAATAGACCTGAGTGGGTGA TTATTGAACAAGGATGCTTTGCTTATTCGATGGTGATCGTTCCACTTTATGATACCCTTGGAAATGAAGCCATCACGTACATAGTCAACA AAGGTAAACCAGGTGAAATGTCAACTACCTGAAAGTATTTTCCAAGTAGACGAACTCTTGCACCGTCTCAATTTTTTTGTAGAAGTATGC AGAAGGTACTTGTGGAAAATGACTGTGGACGCTTCAGAAAATGTACAATGCTGCGTCATATTCAGTCACTTTCCATTTATCTTTAATAAT CTGTCGAAAATTAAACTACTACATACAGACACACTTTTAAAAATAGAGAGTAAAAAACATAAAGCTTATCTTAGGTCGGCAGCAATTGAG GAAGAAAGAGAGTCTGAATTCGCTTTGAGGCCCACGTTTGATCTAACAGTCAGAAGGAATCACTTGATTGAGGATGTTTTGAATCAGCTA AGTCAATTTGAGAATGAAGACCTGAGGAAAGAGTTATGGGTTTCATTTAGTGGAGAAATTGGGTATGACCTCGGAGGAGTCAAGAAAGAG TTCTTCTACTGTCTGTTTGCAGAGATGATCCAGCCGGAATATGGGATGTTCATGTATCCTGAAGGGGCTTCCTGCATGTGGTTTCCTGTC AAGCCTAAATTTGAGAAGAAAAGATACTTCTTTTTTGGGGTTCTATGTGGACTTTCCCTGTTCAATTGCAATGTTGCCAACCTTCCTTTC CCACTGGCACTGTTTAAGAAACTTTTGGACCAAATGCCATCATTGGAAGACTTGAAAGAACTCAGTCCTGATTTGGGAAAGAATTTGCAA ACACTTCTGGATGATGAAGGTGATAACTTTGAGGAAGTATTTTACATCCATTTTAATGTGCACTGGGACAGAAACGACACAAACTTAATT CCTAATGGAAGTAGCATAACTGTCAACCAGACTAACAAGAGAGACTATGTTTCTAAGTATATCAATTACATTTTCAACGACTCTGTAAAG GCGGTTTATGAAGAATTTCGGAGAGGATTTTATAAAATGTGCGACGAAGACATTATCAAATTATTCCACCCCGAAGAACTGAAGGATGTG ATTGTTGGAAATACAGATTATGATTGGAAAACATTTGAAAAGAATGCACGTTATGAACCAGGATATAACAGTTCACATCCCACCATAGTG ATGTTTTGGAAGGCTTTCCACAAATTGACTCTGGAAGAAAAGAAAAAATTCCTTGTATTTCTTACAGGAACTGACAGACTACAAATGAAA GATTTAAATAATATGAAAATAACATTTTGCTGTCCTGAAAGTTGGAATGAAAGAGACCCTATAAGAGCACTGACATGTTTCAGTGTCCTC TTCCTCCCTAAATATTCTACAATGGAAACAGTTGAAGAAGCGCTTCAAGAAGCCATCAACAACAACAGAGGATTTGGCTGACCAGCTTGC TTGTCCAACAGCCTTATTTTGTTGTTGTTATCGTTGTTGTTGTTGTTGTTGTTGTTGTTTCTCTACTTTGTTTTGTTTTAGGCTTTTAGC >1493_1493_10_ACSL1-HERC5_ACSL1_chr4_185698038_ENST00000515030_HERC5_chr4_89407266_ENST00000508159_length(amino acids)=427AA_BP= MHRLNFFVEVCRRYLWKMTVDASENVQCCVIFSHFPFIFNNLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRR NHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLS LFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDRNDTNLIPNGSSITVNQTNKRDYVSK YINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ACSL1-HERC5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ACSL1-HERC5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ACSL1-HERC5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ACSL1 | C0002152 | Alloxan Diabetes | 1 | CTD_human |
| Hgene | ACSL1 | C0003865 | Arthritis, Adjuvant-Induced | 1 | CTD_human |
| Hgene | ACSL1 | C0007097 | Carcinoma | 1 | CTD_human |
| Hgene | ACSL1 | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
| Hgene | ACSL1 | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
| Hgene | ACSL1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | ACSL1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | ACSL1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Hgene | ACSL1 | C0028754 | Obesity | 1 | CTD_human |
| Hgene | ACSL1 | C0038433 | Streptozotocin Diabetes | 1 | CTD_human |
| Hgene | ACSL1 | C0205696 | Anaplastic carcinoma | 1 | CTD_human |
| Hgene | ACSL1 | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human |
| Hgene | ACSL1 | C0205698 | Undifferentiated carcinoma | 1 | CTD_human |
| Hgene | ACSL1 | C0205699 | Carcinomatosis | 1 | CTD_human |
| Hgene | ACSL1 | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
| Hgene | ACSL1 | C0971858 | Arthritis, Collagen-Induced | 1 | CTD_human |
| Hgene | ACSL1 | C0993582 | Arthritis, Experimental | 1 | CTD_human |
| Hgene | ACSL1 | C1257925 | Mammary Carcinoma, Animal | 1 | CTD_human |
| Hgene | ACSL1 | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
| Hgene | ACSL1 | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
| Hgene | ACSL1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| Hgene | ACSL1 | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
| Tgene | C0014175 | Endometriosis | 1 | CTD_human | |
| Tgene | C0021400 | Influenza | 1 | CTD_human | |
| Tgene | C0269102 | Endometrioma | 1 | CTD_human | |
| Tgene | C2239176 | Liver carcinoma | 1 | CTD_human |
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