Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:BPTF-PLXDC1 (FusionGDB2 ID:HG2186TG57125)

Fusion Gene Summary for BPTF-PLXDC1

check button Fusion gene summary
Fusion gene informationFusion gene name: BPTF-PLXDC1
Fusion gene ID: hg2186tg57125
HgeneTgene
Gene symbol

BPTF

PLXDC1

Gene ID

2186

57125

Gene namebromodomain PHD finger transcription factorplexin domain containing 1
SynonymsFAC1|FALZ|NEDDFL|NURF301TEM3|TEM7
Cytomap('BPTF')('PLXDC1')

17q24.2

17q12

Type of geneprotein-codingprotein-coding
Descriptionnucleosome-remodeling factor subunit BPTFbromodomain and PHD domain transcription factorbromodomain and PHD finger-containing transcription factorfetal Alz-50 clone 1 proteinfetal Alz-50 reactive clone 1fetal Alzheimer antigennucleosome remodeling fplexin domain-containing protein 12410003I07Riktumor endothelial marker 3tumor endothelial marker 7
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000306378, ENST00000321892, 
ENST00000335221, ENST00000424123, 
ENST00000577770, 
Fusion gene scores* DoF score27 X 21 X 13=737113 X 9 X 6=702
# samples 4215
** MAII scorelog2(42/7371*10)=-4.1333991254172
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/702*10)=-2.22650852980868
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BPTF [Title/Abstract] AND PLXDC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBPTF(65962772)-PLXDC1(37243955), # samples:3
Anticipated loss of major functional domain due to fusion event.BPTF-PLXDC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BPTF-PLXDC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BPTF-PLXDC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BPTF-PLXDC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBPTF

GO:0000122

negative regulation of transcription by RNA polymerase II

10727212

HgeneBPTF

GO:0006338

chromatin remodeling

14609955


check buttonFusion gene breakpoints across BPTF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PLXDC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-3C-AALI-01ABPTFchr17

65962772

-PLXDC1chr17

37243955

-
ChimerDB4BRCATCGA-3C-AALI-01ABPTFchr17

65962772

+PLXDC1chr17

37243955

-


Top

Fusion Gene ORF analysis for BPTF-PLXDC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000306378ENST00000394316BPTFchr17

65962772

+PLXDC1chr17

37243955

-
5CDS-5UTRENST00000306378ENST00000444911BPTFchr17

65962772

+PLXDC1chr17

37243955

-
5CDS-5UTRENST00000306378ENST00000493200BPTFchr17

65962772

+PLXDC1chr17

37243955

-
5CDS-5UTRENST00000306378ENST00000539608BPTFchr17

65962772

+PLXDC1chr17

37243955

-
5CDS-5UTRENST00000321892ENST00000394316BPTFchr17

65962772

+PLXDC1chr17

37243955

-
5CDS-5UTRENST00000321892ENST00000444911BPTFchr17

65962772

+PLXDC1chr17

37243955

-
5CDS-5UTRENST00000321892ENST00000493200BPTFchr17

65962772

+PLXDC1chr17

37243955

-
5CDS-5UTRENST00000321892ENST00000539608BPTFchr17

65962772

+PLXDC1chr17

37243955

-
5CDS-5UTRENST00000335221ENST00000394316BPTFchr17

65962772

+PLXDC1chr17

37243955

-
5CDS-5UTRENST00000335221ENST00000444911BPTFchr17

65962772

+PLXDC1chr17

37243955

-
5CDS-5UTRENST00000335221ENST00000493200BPTFchr17

65962772

+PLXDC1chr17

37243955

-
5CDS-5UTRENST00000335221ENST00000539608BPTFchr17

65962772

+PLXDC1chr17

37243955

-
5CDS-5UTRENST00000424123ENST00000394316BPTFchr17

65962772

+PLXDC1chr17

37243955

-
5CDS-5UTRENST00000424123ENST00000444911BPTFchr17

65962772

+PLXDC1chr17

37243955

-
5CDS-5UTRENST00000424123ENST00000493200BPTFchr17

65962772

+PLXDC1chr17

37243955

-
5CDS-5UTRENST00000424123ENST00000539608BPTFchr17

65962772

+PLXDC1chr17

37243955

-
In-frameENST00000306378ENST00000315392BPTFchr17

65962772

+PLXDC1chr17

37243955

-
In-frameENST00000321892ENST00000315392BPTFchr17

65962772

+PLXDC1chr17

37243955

-
In-frameENST00000335221ENST00000315392BPTFchr17

65962772

+PLXDC1chr17

37243955

-
In-frameENST00000424123ENST00000315392BPTFchr17

65962772

+PLXDC1chr17

37243955

-
intron-3CDSENST00000577770ENST00000315392BPTFchr17

65962772

+PLXDC1chr17

37243955

-
intron-5UTRENST00000577770ENST00000394316BPTFchr17

65962772

+PLXDC1chr17

37243955

-
intron-5UTRENST00000577770ENST00000444911BPTFchr17

65962772

+PLXDC1chr17

37243955

-
intron-5UTRENST00000577770ENST00000493200BPTFchr17

65962772

+PLXDC1chr17

37243955

-
intron-5UTRENST00000577770ENST00000539608BPTFchr17

65962772

+PLXDC1chr17

37243955

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000335221BPTFchr1765962772+ENST00000315392PLXDC1chr1737243955-1377885496192403059
ENST00000321892BPTFchr1765962772+ENST00000315392PLXDC1chr1737243955-1420789786196693202
ENST00000306378BPTFchr1765962772+ENST00000315392PLXDC1chr1737243955-1382885996092903076
ENST00000424123BPTFchr1765962772+ENST00000315392PLXDC1chr1737243955-133008071087622920

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000335221ENST00000315392BPTFchr1765962772+PLXDC1chr1737243955-0.000682480.9993175
ENST00000321892ENST00000315392BPTFchr1765962772+PLXDC1chr1737243955-0.0006100510.9993899
ENST00000306378ENST00000315392BPTFchr1765962772+PLXDC1chr1737243955-0.0005769590.999423
ENST00000424123ENST00000315392BPTFchr1765962772+PLXDC1chr1737243955-0.0005757780.9994242

Top

Fusion Genomic Features for BPTF-PLXDC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for BPTF-PLXDC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:65962772/chr17:37243955)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBPTFchr17:65962772chr17:37243955ENST00000306378+26282022_205028462921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65962772chr17:37243955ENST00000306378+26282706_273228462921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65962772chr17:37243955ENST00000306378+2628574_60428462921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65962772chr17:37243955ENST00000306378+2628978_100728462921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65962772chr17:37243955ENST00000321892+28302022_205029723047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65962772chr17:37243955ENST00000321892+28302706_273229723047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65962772chr17:37243955ENST00000321892+2830574_60429723047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65962772chr17:37243955ENST00000321892+2830978_100729723047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65962772chr17:37243955ENST00000335221+28302022_205028292904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65962772chr17:37243955ENST00000335221+28302706_273228292904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65962772chr17:37243955ENST00000335221+2830574_60428292904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65962772chr17:37243955ENST00000335221+2830978_100728292904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65962772chr17:37243955ENST00000306378+2628143_18028462921.0Compositional biasNote=Glu-rich
HgeneBPTFchr17:65962772chr17:37243955ENST00000306378+2628149_18528462921.0Compositional biasNote=Asp-rich
HgeneBPTFchr17:65962772chr17:37243955ENST00000306378+26281709_180328462921.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65962772chr17:37243955ENST00000306378+26282338_236128462921.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65962772chr17:37243955ENST00000306378+26282795_281728462921.0Compositional biasNote=Pro-rich
HgeneBPTFchr17:65962772chr17:37243955ENST00000321892+2830143_18029723047.0Compositional biasNote=Glu-rich
HgeneBPTFchr17:65962772chr17:37243955ENST00000321892+2830149_18529723047.0Compositional biasNote=Asp-rich
HgeneBPTFchr17:65962772chr17:37243955ENST00000321892+28301709_180329723047.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65962772chr17:37243955ENST00000321892+28302338_236129723047.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65962772chr17:37243955ENST00000321892+28302795_281729723047.0Compositional biasNote=Pro-rich
HgeneBPTFchr17:65962772chr17:37243955ENST00000321892+28302848_285329723047.0Compositional biasNote=Poly-Lys
HgeneBPTFchr17:65962772chr17:37243955ENST00000335221+2830143_18028292904.0Compositional biasNote=Glu-rich
HgeneBPTFchr17:65962772chr17:37243955ENST00000335221+2830149_18528292904.0Compositional biasNote=Asp-rich
HgeneBPTFchr17:65962772chr17:37243955ENST00000335221+28301709_180328292904.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65962772chr17:37243955ENST00000335221+28302338_236128292904.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65962772chr17:37243955ENST00000335221+28302795_281728292904.0Compositional biasNote=Pro-rich
HgeneBPTFchr17:65962772chr17:37243955ENST00000306378+2628240_30028462921.0DomainDDT
HgeneBPTFchr17:65962772chr17:37243955ENST00000321892+2830240_30029723047.0DomainDDT
HgeneBPTFchr17:65962772chr17:37243955ENST00000335221+2830240_30028292904.0DomainDDT
HgeneBPTFchr17:65962772chr17:37243955ENST00000306378+2628390_43728462921.0Zinc fingerPHD-type 1
HgeneBPTFchr17:65962772chr17:37243955ENST00000321892+28302867_291829723047.0Zinc fingerPHD-type 2
HgeneBPTFchr17:65962772chr17:37243955ENST00000321892+2830390_43729723047.0Zinc fingerPHD-type 1
HgeneBPTFchr17:65962772chr17:37243955ENST00000335221+2830390_43728292904.0Zinc fingerPHD-type 1
TgenePLXDC1chr17:65962772chr17:37243955ENST00000315392614448_500270501.0Topological domainCytoplasmic
TgenePLXDC1chr17:65962772chr17:37243955ENST00000394316610448_500270338.0Topological domainCytoplasmic
TgenePLXDC1chr17:65962772chr17:37243955ENST00000315392614427_447270501.0TransmembraneHelical
TgenePLXDC1chr17:65962772chr17:37243955ENST00000394316610427_447270338.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBPTFchr17:65962772chr17:37243955ENST00000306378+26282848_285328462921.0Compositional biasNote=Poly-Lys
HgeneBPTFchr17:65962772chr17:37243955ENST00000335221+28302848_285328292904.0Compositional biasNote=Poly-Lys
HgeneBPTFchr17:65962772chr17:37243955ENST00000306378+26282944_301428462921.0DomainBromo
HgeneBPTFchr17:65962772chr17:37243955ENST00000321892+28302944_301429723047.0DomainBromo
HgeneBPTFchr17:65962772chr17:37243955ENST00000335221+28302944_301428292904.0DomainBromo
HgeneBPTFchr17:65962772chr17:37243955ENST00000306378+26282867_291828462921.0Zinc fingerPHD-type 2
HgeneBPTFchr17:65962772chr17:37243955ENST00000335221+28302867_291828292904.0Zinc fingerPHD-type 2
TgenePLXDC1chr17:65962772chr17:37243955ENST0000031539261419_426270501.0Topological domainExtracellular
TgenePLXDC1chr17:65962772chr17:37243955ENST0000039431661019_426270338.0Topological domainExtracellular


Top

Fusion Gene Sequence for BPTF-PLXDC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10098_10098_1_BPTF-PLXDC1_BPTF_chr17_65962772_ENST00000306378_PLXDC1_chr17_37243955_ENST00000315392_length(transcript)=13828nt_BP=8599nt
GCCCCCCCTGCGCCCGCCCCTCCCCCTTCGCTTTCCTTCTCCCCCCGCCTCGGCTCCGACATGAGGGGCCGGCGGGGCAGGCCGCCCAAG
CAGCCCGCGGCTCCCGCTGCGGAGCGCTGCGCCCCGGCCCCGCCGCCACCGCCGCCGCCGCCCACGTCCGGACCCATCGGGGGGCTCCGC
TCGCGGCACCGCGGCAGCAGCCGGGGCAGGTGGGCCGCCGCCCAGGCTGAGGTGGCGCCCAAGACGCGGCTGAGCTCGCCCAGGGGGGGC
AGCAGTAGCCGGAGGAAGCCGCCGCCGCCGCCGCCGGCCCCCCCCAGCACCAGCGCCCCGGGCCGGGGGGGGCGAGGAGGCGGGGGCGGC
AGGACGGGGGGCGGGGGCGGCGGCGGCCACCTGGCCCGGACCACCGCGGCCCGGAGGGCCGTCAACAAAGTGGTGTACGATGACCACGAG
AGCGAGGAGGAGGAGGAAGAGGAGGACATGGTCTCCGAGGAGGAGGAGGAGGAGGACGGCGACGCCGAGGAGACCCAGGATTCTGAGGAC
GACGAGGAGGATGAGATGGAAGAGGACGACGATGACTCCGATTATCCGGAGGAGATGGAAGACGACGACGACGACGCCAGTTACTGCACG
GAAAGCAGCTTCAGGAGCCATAGTACCTACAGCAGCACTCCAGGTAGGCGAAAACCAAGAGTACATCGGCCTCGTTCTCCTATATTGGAA
GAAAAAGACATCCCGCCCCTTGAATTTCCCAAGTCCTCTGAGGATTTAATGGTGCCTAATGAGCATATAATGAATGTCATTGCCATTTAC
GAGGTACTGCGGAACTTTGGCACTGTTTTGAGATTATCTCCTTTTCGCTTTGAGGACTTTTGTGCAGCTCTGGTGAGCCAAGAGCAGTGC
ACACTCATGGCAGAGATGCATGTTGTGCTTTTGAAAGCAGTTCTGCGTGAAGAAGACACTTCCAATACTACCTTTGGACCTGCTGATCTG
AAAGATAGCGTTAATTCCACACTGTATTTCATAGATGGGATGACGTGGCCAGAGGTGCTGCGGGTGTACTGTGAGAGTGATAAGGAGTAC
CATCACGTTCTTCCTTACCAAGAGGCAGAGGACTACCCATATGGACCAGTAGAGAACAAGATCAAAGTTCTACAGTTTCTAGTCGATCAG
TTTCTTACAACAAATATTGCTCGAGAGGAATTGATGTCTGAAGGGGTGATACAGTATGATGACCATTGTAGGGTTTGTCACAAACTTGGG
GATTTGCTTTGCTGTGAGACATGTTCAGCAGTATACCATTTGGAATGTGTGAAGCCACCTCTTGAGGAGGTGCCAGAGGACGAGTGGCAG
TGTGAAGTCTGTGTAGCACACAAGGTGCCTGGTGTGACTGACTGTGTTGCTGAAATCCAAAAAAATAAACCATATATTCGACATGAACCT
ATTGGATATGATAGAAGTCGGAGGAAATACTGGTTCTTGAACCGAAGACTCATAATAGAAGAAGATACAGAAAATGAAAATGAAAAGAAA
ATTTGGTATTACAGCACAAAGGTCCAACTTGCAGAATTAATTGACTGTCTAGACAAAGATTATTGGGAAGCAGAACTCTGCAAAATTCTA
GAAGAAATGCGTGAAGAAATCCACCGACACATGGACATAACTGAAGACCTGACCAATAAGGCTCGGGGCAGTAACAAATCCTTTCTGGCG
GCAGCTAATGAAGAAATTTTGGAATCCATAAGAGCCAAAAAGGGAGACATTGATAATGTTAAAAGCCCAGAAGAAACAGAAAAAGACAAG
AATGAGACTGAGAATGACTCTAAAGATGCTGAGAAAAACAGAGAAGAATTTGAAGACCAGTCCCTTGAAAAAGACAGTGACGACAAAACA
CCAGATGATGACCCTGAGCAAGGAAAATCTGAGGTAGGTGATTTCAAATCGGAGAAGTCCAACGGGGAGCTAAGTGAATCTCCTGGAGCT
GGAAAAGGAGCATCTGGCTCAACTCGAATCATCACCAGATTGCGGAATCCAGATAGCAAACTTAGTCAGCTGAAGAGCCAGCAGGTGGCA
GCCGCTGCACATGAAGCAAATAAATTATTTAAGGAGGGCAAAGAGGTACTGGTAGTTAACTCTCAAGGAGAAATTTCACGGTTGAGCACC
AAAAAGGAAGTGATCATGAAAGGAAATATCAACAATTATTTTAAATTGGGTCAAGAAGGGAAGTATCGCGTCTACCACAATCAATACTCC
ACCAATTCATTTGCTTTGAATAAGCACCAGCACAGAGAAGACCATGATAAGAGAAGGCATCTTGCACATAAGTTCTGTCTGACTCCAGCA
GGAGAGTTCAAATGGAACGGTTCTGTCCATGGGTCCAAAGTTCTTACCATATCTACTCTGAGACTGACTATCACCCAATTAGAAAACAAC
ATCCCTTCATCCTTTCTTCATCCCAACTGGGCATCACATAGGGCAAATTGGATCAAGGCAGTTCAGATGTGTAGCAAACCCAGAGAATTT
GCATTGGCTTTAGCCATTTTGGAGTGTGCAGTTAAACCAGTTGTGATGCTACCAATATGGCGAGAATCTTTAGGACATACCAGGTTACAC
CGGATGACATCAATTGAAAGAGAAGAAAAGGAGAAAGTCAAAAAAAAAGAGAAGAAACAGGAAGAAGAAGAAACGATGCAGCAAGCGACA
TGGGTAAAATACACATTTCCAGTTAAGCATCAGGTTTGGAAACAAAAAGGTGAAGAGTACAGAGTGACAGGATATGGTGGTTGGAGCTGG
ATTAGTAAAACTCATGTTTATAGGTTTGTTCCTAAATTGCCAGGCAATACTAATGTGAATTACAGAAAGTCGTTAGAAGGAACCAAAAAT
AATATGGATGAAAATATGGATGAGTCAGATAAAAGAAAATGTTCACGAAGTCCAAAAAAAATAAAAATAGAGCCTGATTCTGAAAAAGAT
GAGGTAAAAGGTTCAGATGCTGCAAAAGGAGCAGACCAAAATGAAATGGATATCTCAAAGATTACTGAGAAGAAGGACCAAGATGTGAAG
GAGCTCTTAGATTCTGACAGTGATAAACCCTGCAAGGAAGAACCAATGGAAGTAGACGATGACATGAAAACAGAGTCACATGTAAATTGT
CAGGAGAGTTCTCAAGTAGATGTGGTCAATGTTAGTGAGGGTTTTCATCTAAGGACTAGTTACAAAAAGAAAACAAAATCATCCAAACTA
GATGGACTTCTTGAAAGGAGAATTAAACAGTTTACACTGGAAGAAAAACAGCGACTCGAAAAAATCAAGTTGGAGGGTGGAATTAAGGGT
ATAGGAAAGACTTCTACAAATTCTTCAAAAAATCTCTCTGAATCACCAGTAATAACGAAAGCAAAAGAAGGGTGTCAGAGTGACTCGATG
AGACAAGAACAGAGCCCAAATGCAAATAATGATCAACCTGAGGACTTGATTCAGGGATGTTCAGAAAGTGATTCCTCAGTTCTTAGAATG
AGTGATCCTAGTCATACCACAAACAAACTTTATCCAAAAGATCGAGTGTTAGATGATGTCTCCATTCGGAGCCCAGAAACAAAATGTCCG
AAACAAAATTCCATTGAAAATGACATAGAAGAAAAAGTCTCTGACCTTGCCAGTAGAGGCCAGGAACCCAGTAAGAGTAAAACAAAAGGA
AATGATTTTTTCATCGATGACTCTAAACTAGCCAGTGCAGATGATATTGGTACTTTGATCTGTAAGAACAAAAAACCGCTCATACAGGAG
GAAAGTGACACCATTGTTTCTTCTTCCAAGAGTGCTTTACATTCATCAGTGCCTAAAAGTACCAATGACAGAGATGCCACACCTCTGTCA
AGAGCAATGGACTTTGAAGGAAAACTGGGATGTGACTCTGAATCTAATAGCACTTTGGAAAATAGTTCTGATACCGTGTCTATTCAGGAT
AGCAGTGAAGAAGATATGATTGTTCAGAATAGCAATGAAAGCATTTCTGAACAGTTCAGAACTCGAGAACAAGATGTTGAAGTCTTGGAG
CCGTTAAAGTGTGAGTTGGTTTCTGGTGAGTCCACTGGAAACTGTGAGGACAGGCTGCCGGTCAAGGGGACTGAAGCAAATGGTAAAAAA
CCAAGTCAGCAGAAGAAATTAGAGGAGAGACCAGTTAATAAATGTAGTGATCAAATAAAGCTAAAAAATACCACTGACAAAAAGAATAAT
GAAAATCGAGAGTCTGAAAAGAAAGGACAGAGAACAAGTACATTTCAAATAAATGGAAAAGATAATAAACCCAAAATATATTTGAAAGGT
GAATGCTTGAAAGAAATTTCTGAGAGTAGAGTAGTAAGTGGTAATGTTGAACCAAAGGTTAATAATATAAATAAAATAATCCCTGAGAAT
GATATTAAATCATTGACTGTTAAAGAATCTGCTATAAGGCCATTCATTAATGGTGATGTCATCATGGAAGATTTTAATGAAAGAAACAGC
TCCGAAACAAAATCGCATTTGCTGAGTTCTTCAGATGCTGAAGGTAACTACCGAGATAGCCTTGAGACCCTGCCATCAACCAAAGAGTCT
GACAGTACACAGACGACCACACCCTCAGCATCTTGTCCAGAAAGCAATTCAGTTAATCAGGTAGAAGATATGGAAATAGAAACCTCAGAA
GTTAAGAAAGTTACTTCATCACCTATTACTTCTGAAGAGGAATCTAATCTCAGTAATGACTTTATTGATGAAAATGGTCTGCCCATCAAC
AAAAATGAAAATGTCAATGGAGAATCTAAAAGAAAAACCGTCATCACAGAAGTCACCACGATGACCTCCACAGTGGCCACAGAATCAAAA
ACTGTGATCAAGGTAGAAAAAGGCGATAAGCAAACTGTGGTTTCTTCCACAGAAAATTGTGCAAAATCCACTGTCACAACCACCACTACA
ACAGTGACCAAGCTTTCCACACCCTCCACAGGCGGCAGTGTGGACATCATCTCTGTAAAGGAGCAGAGCAAAACCGTGGTCACCACGACA
GTGACAGACTCCCTGACCACCACGGGAGGCACACTGGTTACATCTATGACTGTGAGCAAAGAGTATTCCACACGAGACAAAGTGAAACTG
ATGAAATTTTCAAGACCAAAGAAGACTCGTTCAGGTACAGCTCTGCCATCCTATAGAAAATTTGTTACCAAGAGCAGCAAGAAGAGCATT
TTTGTTTTGCCTAATGATGACTTAAAAAAGTTGGCCCGAAAAGGAGGAATCCGAGAGGTCCCTTATTTTAATTACAATGCAAAACCTGCT
TTGGATATATGGCCATATCCTTCTCCTAGACCGACCTTTGGCATCACTTGGAGGTATAGACTTCAGACAGTAAAGTCCTTAGCTGGAGTG
AGCCTGATGTTACGGTTACTGTGGGCAAGTTTGAGATGGGATGATATGGCGGCCAAGGCTCCTCCAGGAGGAGGGACTACACGGACAGAA
ACATCCGAAACTGAAATCACAACAACAGAAATAATTAAGAGGAGAGATGTTGGTCCTTATGGCATTCGATCTGAATATTGTATCAGGAAA
ATCATTTGTCCCATTGGAGTTCCAGAAACACCAAAAGAAACGCCTACACCTCAGAGGAAAGGCCTTCGATCAAGTGCACTGCGGCCAAAG
AGACCAGAAACGCCCAAGCAAACTGGCCCTGTTATTATTGAAACCTGGGTAGCAGAAGAAGAACTGGAATTGTGGGAGATCAGGGCATTT
GCTGAGAGAGTGGAGAAAGAAAAGGCACAAGCAGTTGAGCAACAGGCTAAGAAACGACTGGAGCAGCAGAAGCCGACAGTGATTGCAACT
TCCACTACTTCCCCAACAAGCAGTACAACCAGCACCATCTCTCCAGCACAGAAGGTTATGGTGGCCCCCATAAGTGGCTCAGTTACAACT
GGAACCAAAATGGTACTAACTACTAAAGTTGGATCTCCAGCTACAGTAACATTCCAACAAAACAAGAACTTTCATCAAACCTTTGCTACA
TGGGTTAAGCAAGGCCAGTCAAATTCAGGCGTTGTTCAAGTACAGCAGAAAGTCCTGGGTATCATTCCATCAAGTACAGGTACCAGTCAG
CAAACCTTTACTTCATTCCAGCCCAGGACAGCAACAGTCACAATTAGGCCCAATACCTCAGGCTCTGGAGGAACCACAAGCAATTCACAA
GTAATCACAGGGCCTCAGATTCGCCCTGGTATGACCGTGATTAGAACACCACTCCAACAGTCAACACTAGGAAAGGCAATTATTCGAACA
CCTGTGATGGTACAGCCAGGTGCTCCTCAGCAAGTGATGACTCAAATCATCAGGGGGCAGCCTGTCTCCACTGCAGTCTCCGCCCCTAAC
ACGGTTTCCTCAACACCTGGGCAGAAAAGCTTAACTTCAGCAACGTCCACTTCAAATATACAGTCTTCAGCCTCACAACCCCCTCGCCCC
CAACAAGGACAAGTGAAGCTCACCATGGCTCAACTTACTCAGTTAACACAGGGCCACGGTGGCAATCAAGGTTTGACAGTAGTAATTCAA
GGACAAGGTCAAACTACTGGACAGTTGCAGTTGATACCTCAAGGGGTGACTGTACTCCCAGGCCCAGGCCAGCAGCTAATGCAAGCTGCA
ATGCCAAATGGTACTGTTCAGCGATTCCTCTTTACCCCATTGGCAACAACAGCCACCACAGCCAGCACCACCACCACCACTGTTTCCACG
ACAGCAGCAGGTACAGGTGAACAAAGGCAGAGTAAACTGTCACCCCAGATGCAGGTACATCAAGACAAAACCCTGCCACCAGCTCAGTCA
TCAAGTGTGGGTCCAGCAGAAGCCCAGCCACAGACTGCTCAGCCTTCAGCTCAGCCCCAGCCCCAAACCCAGCCCCAGTCCCCAGCTCAG
CCTGAAGTTCAGACTCAGCCTGAAGTTCAGACCCAAACAACTGTTTCATCCCATGTCCCTTCTGAAGCACAACCCACCCACGCACAGTCA
TCCAAGCCCCAAGTTGCAGCACAGTCTCAGCCTCAAAGTAATGTCCAAGGACAGTCTCCTGTTCGTGTCCAAAGTCCATCACAGACTCGA
ATACGTCCATCAACTCCATCCCAACTGTCTCCTGGACAACAATCCCAGGTTCAGACTACAACCTCACAACCGATTCCAATTCAACCACAT
ACATCTCTTCAGATACCTTCCCAAGGCCAGCCACAGTCACAACCCCAGGTACAGTCTTCAACTCAAACTCTTTCATCAGGACAAACTTTA
AATCAAGTTACTGTTTCATCCCCATCCCGTCCTCAGCTACAAATACAGCAGCCACAGCCCCAAGTCATTGCTGTGCCTCAGCTGCAACAA
CAAGTCCAGGTTCTCTCTCAGATCCAGTCACAGGTTGTGGCTCAGATACAGGCTCAGCAAAGTGGTGTGCCCCAGCAAATCAAACTCCAG
TTACCTATCCAAATTCAGCAAAGCAGTGCTGTGCAGACTCACCAGATTCAGAATGTGGTTACAGTGCAGGCAGCCAGTGTGCAAGAGCAG
TTGCAAAGGGTTCAGCAACTCAGGGATCAGCAGCAAAAGAAGAAACAGCAACAGATAGAAATTAAGCGTGAACACACCCTCCAAGCTTCT
AATCAAAGTGAAATCATTCAGAAACAGGTGGTGATGAAGCATAATGCTGTAATAGAACATTTAAAACAGAAAAAGAGCATGACTCCAGCT
GAAAGAGAAGAGAATCAAAGAATGATTGTCTGTAACCAGGTGATGAAGTATATTTTGGATAAGATAGATAAAGAAGAAAAACAGGCAGCA
AAAAAACGGAAGCGTGAAGAGAGTGTGGAGCAGAAACGTAGCAAGCAGAATGCCACTAAGCTGTCAGCTCTGCTCTTCAAGCACAAAGAG
CAGCTCAGAGCCGAGATCCTGAAGAAGAGAGCACTCCTGGACAAGGATCTGCAAATTGAAGTGCAGGAAGAGCTGAAGAGAGACCTGAAA
ATTAAGAAAGAAAAAGACCTGATGCAGTTGGCTCAGGCCACAGCAGTAGCTGCACCCTGCCCCCCAGTGACACCAGCTCCTCCAGCCCCT
CCAGCCCCTCCACCTTCACCTCCCCCTCCACCTGCTGTGCAACACACAGGCCTTCTGTCCACGCCCACCTTACCTGCTGCTTCCCAGAAG
AGGAAGCGGGAAGAGGAAAAAGACTCCAGCTCAAAGTCCAAGAAAAAGAAAATGATCTCTACTACCTCAAAGGAAACTAAGAAGGACACA
AAGCTTTACTGTATCTGTAAAACGCCTTATGATGAATCTAAATTTTATATTGGCTGTGATCGGTGTCAGAATTGGTACCATGGGCGCTGC
GTTGGCATCTTGCAAAGTGAGGCAGAGCTCATTGATGAGTATGTCTGTCCACAGTGCCAGTCAACAGAGGATGCCATGACAGTGCTCACG
CCACTAACAGAGAAGGATTATGAGGGGTTGAAGAGGGTGCTCCGTTCCTTACAGGCCCATAAGATGGCCTGGCCTTTCCTTGAACCAGTA
GACCCTAATGATGCACCAGATTATTATGGTGTTATTAAGGAACCTATGGAATCTCGGCGAAGGAGCATCTTTGAATATCACCGCATAGAG
CTGGACCCCAGCAAGGTCACCAGCATGTCGGCCGTGGAGTTCACCCCATTGCCGACCTGCCTGCAGCATAGGAGCTGTGACGCCTGCATG
TCCTCAGACCTGACCTTCAACTGCAGCTGGTGCCATGTCCTCCAGAGATGCTCCAGTGGCTTTGACCGCTATCGCCAGGAGTGGATGGAC
TATGGCTGTGCACAGGAGGCAGAGGGCAGGATGTGCGAGGACTTCCAGGATGAGGACCACGACTCAGCCTCCCCTGACACTTCCTTCAGC
CCCTATGATGGAGACCTCACCACTACCTCCTCCTCCCTCTTCATCGACAGCCTCACCACAGAAGATGACACCAAGTTGAATCCCTATGCA
GGAGGAGACGGCCTTCAGAACAACCTGTCCCCCAAGACAAAGGGCACTCCTGTGCACCTGGGCACCATCGTGGGCATCGTGCTGGCAGTC
CTCCTCGTGGCGGCCATCATCCTGGCTGGAATTTACATCAATGGCCACCCCACATCCAATGCTGCGCTCTTCTTCATCGAGCGTAGACCT
CACCACTGGCCAGCCATGAAGTTTCGCAGCCACCCTGACCATTCCACCTATGCGGAGGTGGAGCCCTCGGGCCATGAGAAGGAGGGCTTC
ATGGAGGCTGAGCAGTGCTGAGAACACCAAGTCTCCCCTTTGAAGACTTTGAGGCCACAGAAAAGACAGTTAAAGCAAAGAAGAGAAGTG
ACTTTTCCTGGCCTCTCCCAGCATGCCCTGGGCTGAGATGAGATGGTGGTTTATGGCTCCAGAGCTGCTGCTCGCTTCGTCAGCACACCC
CGAATATTGAAGAGGGGGCCAAAAAACAACCACATGGATTTTTTATAGGAACAACAACCTAATCTCATCCTGTTTTGATGCAAGGGTTCT
CTTCTGTGTCTTGTAACCATGAAACAGCAGAAGAACTAACATAACTAACTCCATTTTTGTTTAAGGGGCCTTTACCTATTCCTGCACCTA
GGCTAGGATAACTTTAGAGCACTGACATAAAACGCAAAAACAGGAATCATGCCGTTTGCAAAACTAACTCTGGGATTAAAGGGGAAGCAT
GTAAACAGCTAACTGTTTTTGTTAAAGATTTATAGGAATGAGGAGGTTTGGCTATTGTCACATGACAGACTGTTAGCCAAGGACAAAGAA
GTTCTGCAAACCTCCCCTGGACCCTTGCTGGTGTCCAGATGTCTGCGGTTGTCAGCCCCTTCCTTTCCCCCGACCTAAACATAAAAGACA
AGGCAAAGCCCGCATAATTTTAAGACGGTTCTTTAGGACATTAGTCCACCATCTTCTTGGTTTGCTGGCTCTCCGAAATAAAGTCCCTTT
CCTTGCTCCAACTCCTTGTCTCTCAACGTATTGGCTATGACGCAGCAAGCAGAATGAATTTGGACTCAGTTACAGGCTGTCAATGGTCTG
CTCTGTAGCAGTCTCAGAGCCTCCCCGACCCACTACCTGGAGATAGCCAGATAGCCAGATGCCCTGCTCCTGGCCACCTTTAAAGCCCCT
GCATATGACACAGGTTAACTAAAGTCAAGATTGGGGCTGCTGCATTCCAGGTTCCCTAGACTCACAAGCTGGTCCTTGGCCAGGTGCAGT
GGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACCTGAAGTCAGAAGTTTGAGACCAGCCTGGCCAACATAAT
TAAAATGTCTCTACTAAAAATACAAAAAATTAGCTGGGTGTGGTGACGCTTGCCTGTATCCCAGCTACTCAGGAAGCTGAGACACGAGAA
TCACTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCTCAGATAGTGCCACTGCACTCCAGCCTGGGTGACAGAGCGAGACTCCGTCTCAAA
AAAAAAAAAAGAAAGCAGATCCTCATGGCTATAGAGTTGGCATTTTAGCCCCAGCTTCTGTAGCTCTGAAAGCCTAAAGAAGGTATTCTC
TCCATCTGTTAAACACAGTATAGTGGCTCTCAGCCCTTGGGGCATGTTATCATGGGAGGGAAGTCAAATAAGAGGAGAGAAAAGAACTCA
AGGGGGAAACTGCATTTTTAGGCTTTGCTCTCTTACCTTGCCCTTTCTACTCAGAACCAATAACTTCTGCATCAAAACATGTTACAGCCT
GCATCAAGGGCTTTACCCCAACCTGCAGCCCAGCCTTCCCTGGGTGAGCTTGCTATGCGCAGCCACATTTACCATGTGGGGCTCCCTATT
CTGATGGCCTGTTCGGTGCCGGGTTTACTCACTGCCCTGTTCTGATGTCAGTGCCTGTACATACCTCCAAAGGCAGGACTTGCCTGATAA
ATATTTTTCCTCCTCTGAACTGGATTTTATAGGCATTAAAGACAAGTCGGGTGGCTAGAGGGCTCCTTGAGACATACCTAGCAGGGAACT
GCAGGTGGATTCTGTTGAGAGGCAAAGCACCTGAGTGGTTGGGACACAGGCAGCTGGCATGGGAGGGACTTTTTTTGAGACAGGGTCTCA
CTGTGTCGCCCAGGGCAAGGATGCCCAAAGACACCAGGTTGGAGAGGCACCTGCCAACTACTTGCTTTCCCTGGAGCCTGCATGTGCCTG
TGGGGTGGGGAGGCGTAGGGGTCTACGGCTGCCTGAGATGGGTGTGCACAGTGTGTGAAGTACCTACCTCCTTGCCTTGCTGGACTGTCA
GCCAGTCGCAGGGCCGGCCACAAGACCCATGTCTCCATCTGGTCATACTCCATAGCTACCAAGTTAACCTGCTCTAAACTTTGGAGAACT
GGATCTGTCCAATAAACGCTTATTTGGCCAAGCCTGATGGCTCGTGCCTGTACTCCCAGCACTTTGGGAGGCTGAGGTGGGAGGGTTGCT
TGAGCCCAGGGGTTTGAGACCAGCTTGGGCAACAACAACAAAAATGCCAGGTGTGGTGGGGTGCACCTGTAGTCCCAGCTACTAGGGAGG
CTGAGCCAGGAGGATCACTTGAGCCCGGGAGGTTGAGGCTGCAGTGGGGGGTCATAATCATGCCACTGTACTCCAGCCTGGGTGACAGAG
TGAGACCCTGTCTCCGAAAAAAAAAAAAAAAAAAAGAACGGAAAAAGAAATGCTTACATTGTCAGGGATCCTGTAGACAATCATTAACTC
TATGAGATGCTTGGTTCTATTTTTTTGGGAGACTTTGTCCAAGTGTTTTGGCTTAAGAAATCCATAGGCCTCTCTTGGTGACACATCTCT
AGTACTTTTTGTCATAAACAAACAGGCCATCTGCCGCCAAATACATCCACTCCCCATGCCACTGACATCCTATGGGTCAGCCAGGCTTGC
TTTGACTGAGGCCGAGGCATCTGGAACTTTCTCTGCCTGCAGGGGCTAGCAGCAGAGGCTTCACCGCATCACCACCCCTTCCTCCACTCC
TGACATTCTTTCCCTTCAGGGATCCAAAATGGTTGGCCGAGCTCCCAGTGGGAAAACGTGTGCTAGAGTTGGGGAGTGAGATGAGTGGTG
CTGTCCATGGAATCAGGCCACAGCAGGAACTGCCCCACTGGCCATTTGAGACACACACAGGTGGTAAATGCTCTGCTGGTGGGCTGTGCT
TCCCTCATTCAGAGAGCTCTGTTACAGCCCACTGTGTCCTTTAGAAGCTTGAAAGGAACCCAACTCTTTGCTGCACTGTCCTTTTTCTTC
CTCAAATTCAGACCCTCCTTCCACCGGCACCCCCCTACTCCACCCTCAGCTCTTCCTTGCCTGGTTTATCAAGCAGAGCTGAGGCCCCAC
GTTTCCAACTCTGATTGTCACTTGCATCTTCACAAAGGATAAACCACGGAGCAACTGGAAAACCATCAGCCAAGCGTTCGGATGAGTCTG
GTTATTGGTCCACCCCCGACCAGATTCCCTTACACTTAACTCACTTCTTTCTTTGGCAATGACCCTCATGACATGTATAAATGGGTATGA
CTAAGAAGAGGCTGTGATCTAACATTTATTTGCTGCCATTTTTTACTCTGGGGAGAAGCAGCCCCAACTCATCACTGGGAAAGAACTCCC
CCTGCAAACCAGCTAAATTTGATAATTTAAACCCCCTGCCCCTAAAACTTCTCACAGAGCTGGGGAGTTGGTGGCAACTTTCCAAGTCAA
GGTCTTGCTTAGAAAGTCCTTCACTACATGGCCAGGTGCAGTGGCTCACGCCTGTAGTCCCAGGTACTTGGGAGCCTGAGGCAGGAGGAT
TGCTTGAGCTCAGGAGTTCAAGGCTGCAGAGAGCTATGATCATCCCACTGCATTTGTTTAAAAATAAATTTTTAAAATTTGTGTGTTTTA
TCAGGGGTCTCCTGTACAGTGTATCTGTGTATGTTTGTGTGTGTGTTTGTATACAGCCTTGTTTAATGTTTTGAGCAATAAGATATGCAC
ACACAGGTATTTTGTTGCTAAAGAGATTGGACAAGGTTGTAGCTGTGCTCAGGCTTCAGCTTGGTTTGTTAAATTGAGAGATAAACAATG
ACAAGAGCTGCCAGCCAACCACACTATTCAAAAAGCAAAGTGTTCACCACTAAAGCTAACCATTCATCTGGTTGCAGGCAAGGCTAAGGC
TCTCTCTCCTCTAGTTCCTGGAACAGACTCACAGATTGGCATGAAGCACTGATCAGGGGCTGCACTCAGACTCCCTGGCCAAGCAAACCT
ACACCAGAAGAGTCAGTGTCACAGATATGATGCGGCCAATCTCTGTCTCCAAAAACCTACCTGAACTTAATGGTAGAATTCAAAGATCTG
GGGACTGAGGGCACCCAGCCTTCTAAAACACAATGTATTCATGTGTTTAGTGTAAACTCTCTGCATGGATTCTCAGTGTTAATAATAAAA
GGAAGCATTCTTTTACAACTCCTGCTGTGTGCAAAAGAAAGTGCAAAGGATTTGGAGTGGCATTCCGAAGATCACCACACATACCTTGGT
TCTGATGGCTGCTGAACTCCGACTTCTTCGCTGAGACATGACTGTGGGAACAGCCTCCAGCTATCTGCTCATCAGAGGTGCTTTCCTCAA
CCTCCTGCACCACCTCCAAGAGAAACAGCCTAAAAAGAAACCCCAGCTGTTTACTTATATTGGTCTGTAAATCCCTGGAAGTAAACCCCA

>10098_10098_1_BPTF-PLXDC1_BPTF_chr17_65962772_ENST00000306378_PLXDC1_chr17_37243955_ENST00000315392_length(amino acids)=3076AA_BP=0
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGRRKPRVHRPRSPILEEKDIPPLEFPKSSEDLMVPNEHIMNVIAIYEVLRNFGTVLRLSPFRFEDF
CAALVSQEQCTLMAEMHVVLLKAVLREEDTSNTTFGPADLKDSVNSTLYFIDGMTWPEVLRVYCESDKEYHHVLPYQEAEDYPYGPVENK
IKVLQFLVDQFLTTNIAREELMSEGVIQYDDHCRVCHKLGDLLCCETCSAVYHLECVKPPLEEVPEDEWQCEVCVAHKVPGVTDCVAEIQ
KNKPYIRHEPIGYDRSRRKYWFLNRRLIIEEDTENENEKKIWYYSTKVQLAELIDCLDKDYWEAELCKILEEMREEIHRHMDITEDLTNK
ARGSNKSFLAAANEEILESIRAKKGDIDNVKSPEETEKDKNETENDSKDAEKNREEFEDQSLEKDSDDKTPDDDPEQGKSEVGDFKSEKS
NGELSESPGAGKGASGSTRIITRLRNPDSKLSQLKSQQVAAAAHEANKLFKEGKEVLVVNSQGEISRLSTKKEVIMKGNINNYFKLGQEG
KYRVYHNQYSTNSFALNKHQHREDHDKRRHLAHKFCLTPAGEFKWNGSVHGSKVLTISTLRLTITQLENNIPSSFLHPNWASHRANWIKA
VQMCSKPREFALALAILECAVKPVVMLPIWRESLGHTRLHRMTSIEREEKEKVKKKEKKQEEEETMQQATWVKYTFPVKHQVWKQKGEEY
RVTGYGGWSWISKTHVYRFVPKLPGNTNVNYRKSLEGTKNNMDENMDESDKRKCSRSPKKIKIEPDSEKDEVKGSDAAKGADQNEMDISK
ITEKKDQDVKELLDSDSDKPCKEEPMEVDDDMKTESHVNCQESSQVDVVNVSEGFHLRTSYKKKTKSSKLDGLLERRIKQFTLEEKQRLE
KIKLEGGIKGIGKTSTNSSKNLSESPVITKAKEGCQSDSMRQEQSPNANNDQPEDLIQGCSESDSSVLRMSDPSHTTNKLYPKDRVLDDV
SIRSPETKCPKQNSIENDIEEKVSDLASRGQEPSKSKTKGNDFFIDDSKLASADDIGTLICKNKKPLIQEESDTIVSSSKSALHSSVPKS
TNDRDATPLSRAMDFEGKLGCDSESNSTLENSSDTVSIQDSSEEDMIVQNSNESISEQFRTREQDVEVLEPLKCELVSGESTGNCEDRLP
VKGTEANGKKPSQQKKLEERPVNKCSDQIKLKNTTDKKNNENRESEKKGQRTSTFQINGKDNKPKIYLKGECLKEISESRVVSGNVEPKV
NNINKIIPENDIKSLTVKESAIRPFINGDVIMEDFNERNSSETKSHLLSSSDAEGNYRDSLETLPSTKESDSTQTTTPSASCPESNSVNQ
VEDMEIETSEVKKVTSSPITSEEESNLSNDFIDENGLPINKNENVNGESKRKTVITEVTTMTSTVATESKTVIKVEKGDKQTVVSSTENC
AKSTVTTTTTTVTKLSTPSTGGSVDIISVKEQSKTVVTTTVTDSLTTTGGTLVTSMTVSKEYSTRDKVKLMKFSRPKKTRSGTALPSYRK
FVTKSSKKSIFVLPNDDLKKLARKGGIREVPYFNYNAKPALDIWPYPSPRPTFGITWRYRLQTVKSLAGVSLMLRLLWASLRWDDMAAKA
PPGGGTTRTETSETEITTTEIIKRRDVGPYGIRSEYCIRKIICPIGVPETPKETPTPQRKGLRSSALRPKRPETPKQTGPVIIETWVAEE
ELELWEIRAFAERVEKEKAQAVEQQAKKRLEQQKPTVIATSTTSPTSSTTSTISPAQKVMVAPISGSVTTGTKMVLTTKVGSPATVTFQQ
NKNFHQTFATWVKQGQSNSGVVQVQQKVLGIIPSSTGTSQQTFTSFQPRTATVTIRPNTSGSGGTTSNSQVITGPQIRPGMTVIRTPLQQ
STLGKAIIRTPVMVQPGAPQQVMTQIIRGQPVSTAVSAPNTVSSTPGQKSLTSATSTSNIQSSASQPPRPQQGQVKLTMAQLTQLTQGHG
GNQGLTVVIQGQGQTTGQLQLIPQGVTVLPGPGQQLMQAAMPNGTVQRFLFTPLATTATTASTTTTTVSTTAAGTGEQRQSKLSPQMQVH
QDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTTVSSHVPSEAQPTHAQSSKPQVAAQSQPQSNVQGQSP
VRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQPQVQSSTQTLSSGQTLNQVTVSSPSRPQLQIQQPQP
QVIAVPQLQQQVQVLSQIQSQVVAQIQAQQSGVPQQIKLQLPIQIQQSSAVQTHQIQNVVTVQAASVQEQLQRVQQLRDQQQKKKQQQIE
IKREHTLQASNQSEIIQKQVVMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEEKQAAKKRKREESVEQKRSKQNATK
LSALLFKHKEQLRAEILKKRALLDKDLQIEVQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAPPAPPPSPPPPPAVQHTGLLS
TPTLPAASQKRKREEEKDSSSKSKKKKMISTTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAELIDEYVCPQCQ
STEDAMTVLTPLTEKDYEGLKRVLRSLQAHKMAWPFLEPVDPNDAPDYYGVIKEPMESRRRSIFEYHRIELDPSKVTSMSAVEFTPLPTC
LQHRSCDACMSSDLTFNCSWCHVLQRCSSGFDRYRQEWMDYGCAQEAEGRMCEDFQDEDHDSASPDTSFSPYDGDLTTTSSSLFIDSLTT
EDDTKLNPYAGGDGLQNNLSPKTKGTPVHLGTIVGIVLAVLLVAAIILAGIYINGHPTSNAALFFIERRPHHWPAMKFRSHPDHSTYAEV

--------------------------------------------------------------
>10098_10098_2_BPTF-PLXDC1_BPTF_chr17_65962772_ENST00000321892_PLXDC1_chr17_37243955_ENST00000315392_length(transcript)=14207nt_BP=8978nt
CGCCCCCCCTGCGCCCGCCCCTCCCCCTTCGCTTTCCTTCTCCCCCCGCCTCGGCTCCGACATGAGGGGCCGGCGGGGCAGGCCGCCCAA
GCAGCCCGCGGCTCCCGCTGCGGAGCGCTGCGCCCCGGCCCCGCCGCCACCGCCGCCGCCGCCCACGTCCGGACCCATCGGGGGGCTCCG
CTCGCGGCACCGCGGCAGCAGCCGGGGCAGGTGGGCCGCCGCCCAGGCTGAGGTGGCGCCCAAGACGCGGCTGAGCTCGCCCAGGGGGGG
CAGCAGTAGCCGGAGGAAGCCGCCGCCGCCGCCGCCGGCCCCCCCCAGCACCAGCGCCCCGGGCCGGGGGGGGCGAGGAGGCGGGGGCGG
CAGGACGGGGGGCGGGGGCGGCGGCGGCCACCTGGCCCGGACCACCGCGGCCCGGAGGGCCGTCAACAAAGTGGTGTACGATGACCACGA
GAGCGAGGAGGAGGAGGAAGAGGAGGACATGGTCTCCGAGGAGGAGGAGGAGGAGGACGGCGACGCCGAGGAGACCCAGGATTCTGAGGA
CGACGAGGAGGATGAGATGGAAGAGGACGACGATGACTCCGATTATCCGGAGGAGATGGAAGACGACGACGACGACGCCAGTTACTGCAC
GGAAAGCAGCTTCAGGAGCCATAGTACCTACAGCAGCACTCCAGGTAGGCGAAAACCAAGAGTACATCGGCCTCGTTCTCCTATATTGGA
AGAAAAAGACATCCCGCCCCTTGAATTTCCCAAGTCCTCTGAGGATTTAATGGTGCCTAATGAGCATATAATGAATGTCATTGCCATTTA
CGAGGTACTGCGGAACTTTGGCACTGTTTTGAGATTATCTCCTTTTCGCTTTGAGGACTTTTGTGCAGCTCTGGTGAGCCAAGAGCAGTG
CACACTCATGGCAGAGATGCATGTTGTGCTTTTGAAAGCAGTTCTGCGTGAAGAAGACACTTCCAATACTACCTTTGGACCTGCTGATCT
GAAAGATAGCGTTAATTCCACACTGTATTTCATAGATGGGATGACGTGGCCAGAGGTGCTGCGGGTGTACTGTGAGAGTGATAAGGAGTA
CCATCACGTTCTTCCTTACCAAGAGGCAGAGGACTACCCATATGGACCAGTAGAGAACAAGATCAAAGTTCTACAGTTTCTAGTCGATCA
GTTTCTTACAACAAATATTGCTCGAGAGGAATTGATGTCTGAAGGGGTGATACAGTATGATGACCATTGTAGGGTTTGTCACAAACTTGG
GGATTTGCTTTGCTGTGAGACATGTTCAGCAGTATACCATTTGGAATGTGTGAAGCCACCTCTTGAGGAGGTGCCAGAGGACGAGTGGCA
GTGTGAAGTCTGTGTAGCACACAAGGTGCCTGGTGTGACTGACTGTGTTGCTGAAATCCAAAAAAATAAACCATATATTCGACATGAACC
TATTGGATATGATAGAAGTCGGAGGAAATACTGGTTCTTGAACCGAAGACTCATAATAGAAGAAGATACAGAAAATGAAAATGAAAAGAA
AATTTGGTATTACAGCACAAAGGTCCAACTTGCAGAATTAATTGACTGTCTAGACAAAGATTATTGGGAAGCAGAACTCTGCAAAATTCT
AGAAGAAATGCGTGAAGAAATCCACCGACACATGGACATAACTGAAGACCTGACCAATAAGGCTCGGGGCAGTAACAAATCCTTTCTGGC
GGCAGCTAATGAAGAAATTTTGGAATCCATAAGAGCCAAAAAGGGAGACATTGATAATGTTAAAAGCCCAGAAGAAACAGAAAAAGACAA
GAATGAGACTGAGAATGACTCTAAAGATGCTGAGAAAAACAGAGAAGAATTTGAAGACCAGTCCCTTGAAAAAGACAGTGACGACAAAAC
ACCAGATGATGACCCTGAGCAAGGAAAATCTGAGGAGCCAACAGAAGTTGGGGATAAAGGTAACTCTGTGTCAGCAAATCTTGGCGACAA
CACAACAAATGCAACTTCAGAAGAGACTAGTCCCTCTGAAGGGAGGAGCCCTGTGGGGTGTCTCTCAGAAACCCCCGATAGCAGCAACAT
GGCAGAGAAGAAGGTGGCATCTGAGCTCCCCCAGGATGTGCCAGAAGAACCTAACAAGACATGTGAGAGCAGTAACACTAGTGCTACCAC
TACCTCCATCCAGCCTAATCTGGAAAACAGTAACAGCAGCAGTGAACTAAATTCTTCCCAGAGTGAATCTGCTAAGGCAGCTGATGATCC
TGAAAATGGAGAAAGAGAATCTCATACACCTGTCTCTATTCAGGAAGAGATAGTAGGTGATTTCAAATCGGAGAAGTCCAACGGGGAGCT
AAGTGAATCTCCTGGAGCTGGAAAAGGAGCATCTGGCTCAACTCGAATCATCACCAGATTGCGGAATCCAGATAGCAAACTTAGTCAGCT
GAAGAGCCAGCAGGTGGCAGCCGCTGCACATGAAGCAAATAAATTATTTAAGGAGGGCAAAGAGGTACTGGTAGTTAACTCTCAAGGAGA
AATTTCACGGTTGAGCACCAAAAAGGAAGTGATCATGAAAGGAAATATCAACAATTATTTTAAATTGGGTCAAGAAGGGAAGTATCGCGT
CTACCACAATCAATACTCCACCAATTCATTTGCTTTGAATAAGCACCAGCACAGAGAAGACCATGATAAGAGAAGGCATCTTGCACATAA
GTTCTGTCTGACTCCAGCAGGAGAGTTCAAATGGAACGGTTCTGTCCATGGGTCCAAAGTTCTTACCATATCTACTCTGAGACTGACTAT
CACCCAATTAGAAAACAACATCCCTTCATCCTTTCTTCATCCCAACTGGGCATCACATAGGGCAAATTGGATCAAGGCAGTTCAGATGTG
TAGCAAACCCAGAGAATTTGCATTGGCTTTAGCCATTTTGGAGTGTGCAGTTAAACCAGTTGTGATGCTACCAATATGGCGAGAATCTTT
AGGACATACCAGGTTACACCGGATGACATCAATTGAAAGAGAAGAAAAGGAGAAAGTCAAAAAAAAAGAGAAGAAACAGGAAGAAGAAGA
AACGATGCAGCAAGCGACATGGGTAAAATACACATTTCCAGTTAAGCATCAGGTTTGGAAACAAAAAGGTGAAGAGTACAGAGTGACAGG
ATATGGTGGTTGGAGCTGGATTAGTAAAACTCATGTTTATAGGTTTGTTCCTAAATTGCCAGGCAATACTAATGTGAATTACAGAAAGTC
GTTAGAAGGAACCAAAAATAATATGGATGAAAATATGGATGAGTCAGATAAAAGAAAATGTTCACGAAGTCCAAAAAAAATAAAAATAGA
GCCTGATTCTGAAAAAGATGAGGTAAAAGGTTCAGATGCTGCAAAAGGAGCAGACCAAAATGAAATGGATATCTCAAAGATTACTGAGAA
GAAGGACCAAGATGTGAAGGAGCTCTTAGATTCTGACAGTGATAAACCCTGCAAGGAAGAACCAATGGAAGTAGACGATGACATGAAAAC
AGAGTCACATGTAAATTGTCAGGAGAGTTCTCAAGTAGATGTGGTCAATGTTAGTGAGGGTTTTCATCTAAGGACTAGTTACAAAAAGAA
AACAAAATCATCCAAACTAGATGGACTTCTTGAAAGGAGAATTAAACAGTTTACACTGGAAGAAAAACAGCGACTCGAAAAAATCAAGTT
GGAGGGTGGAATTAAGGGTATAGGAAAGACTTCTACAAATTCTTCAAAAAATCTCTCTGAATCACCAGTAATAACGAAAGCAAAAGAAGG
GTGTCAGAGTGACTCGATGAGACAAGAACAGAGCCCAAATGCAAATAATGATCAACCTGAGGACTTGATTCAGGGATGTTCAGAAAGTGA
TTCCTCAGTTCTTAGAATGAGTGATCCTAGTCATACCACAAACAAACTTTATCCAAAAGATCGAGTGTTAGATGATGTCTCCATTCGGAG
CCCAGAAACAAAATGTCCGAAACAAAATTCCATTGAAAATGACATAGAAGAAAAAGTCTCTGACCTTGCCAGTAGAGGCCAGGAACCCAG
TAAGAGTAAAACAAAAGGAAATGATTTTTTCATCGATGACTCTAAACTAGCCAGTGCAGATGATATTGGTACTTTGATCTGTAAGAACAA
AAAACCGCTCATACAGGAGGAAAGTGACACCATTGTTTCTTCTTCCAAGAGTGCTTTACATTCATCAGTGCCTAAAAGTACCAATGACAG
AGATGCCACACCTCTGTCAAGAGCAATGGACTTTGAAGGAAAACTGGGATGTGACTCTGAATCTAATAGCACTTTGGAAAATAGTTCTGA
TACCGTGTCTATTCAGGATAGCAGTGAAGAAGATATGATTGTTCAGAATAGCAATGAAAGCATTTCTGAACAGTTCAGAACTCGAGAACA
AGATGTTGAAGTCTTGGAGCCGTTAAAGTGTGAGTTGGTTTCTGGTGAGTCCACTGGAAACTGTGAGGACAGGCTGCCGGTCAAGGGGAC
TGAAGCAAATGGTAAAAAACCAAGTCAGCAGAAGAAATTAGAGGAGAGACCAGTTAATAAATGTAGTGATCAAATAAAGCTAAAAAATAC
CACTGACAAAAAGAATAATGAAAATCGAGAGTCTGAAAAGAAAGGACAGAGAACAAGTACATTTCAAATAAATGGAAAAGATAATAAACC
CAAAATATATTTGAAAGGTGAATGCTTGAAAGAAATTTCTGAGAGTAGAGTAGTAAGTGGTAATGTTGAACCAAAGGTTAATAATATAAA
TAAAATAATCCCTGAGAATGATATTAAATCATTGACTGTTAAAGAATCTGCTATAAGGCCATTCATTAATGGTGATGTCATCATGGAAGA
TTTTAATGAAAGAAACAGCTCCGAAACAAAATCGCATTTGCTGAGTTCTTCAGATGCTGAAGGTAACTACCGAGATAGCCTTGAGACCCT
GCCATCAACCAAAGAGTCTGACAGTACACAGACGACCACACCCTCAGCATCTTGTCCAGAAAGCAATTCAGTTAATCAGGTAGAAGATAT
GGAAATAGAAACCTCAGAAGTTAAGAAAGTTACTTCATCACCTATTACTTCTGAAGAGGAATCTAATCTCAGTAATGACTTTATTGATGA
AAATGGTCTGCCCATCAACAAAAATGAAAATGTCAATGGAGAATCTAAAAGAAAAACCGTCATCACAGAAGTCACCACGATGACCTCCAC
AGTGGCCACAGAATCAAAAACTGTGATCAAGGTAGAAAAAGGCGATAAGCAAACTGTGGTTTCTTCCACAGAAAATTGTGCAAAATCCAC
TGTCACAACCACCACTACAACAGTGACCAAGCTTTCCACACCCTCCACAGGCGGCAGTGTGGACATCATCTCTGTAAAGGAGCAGAGCAA
AACCGTGGTCACCACGACAGTGACAGACTCCCTGACCACCACGGGAGGCACACTGGTTACATCTATGACTGTGAGCAAAGAGTATTCCAC
ACGAGACAAAGTGAAACTGATGAAATTTTCAAGACCAAAGAAGACTCGTTCAGGTACAGCTCTGCCATCCTATAGAAAATTTGTTACCAA
GAGCAGCAAGAAGAGCATTTTTGTTTTGCCTAATGATGACTTAAAAAAGTTGGCCCGAAAAGGAGGAATCCGAGAGGTCCCTTATTTTAA
TTACAATGCAAAACCTGCTTTGGATATATGGCCATATCCTTCTCCTAGACCGACCTTTGGCATCACTTGGAGGTATAGACTTCAGACAGT
AAAGTCCTTAGCTGGAGTGAGCCTGATGTTACGGTTACTGTGGGCAAGTTTGAGATGGGATGATATGGCGGCCAAGGCTCCTCCAGGAGG
AGGGACTACACGGACAGAAACATCCGAAACTGAAATCACAACAACAGAAATAATTAAGAGGAGAGATGTTGGTCCTTATGGCATTCGATC
TGAATATTGTATCAGGAAAATCATTTGTCCCATTGGAGTTCCAGAAACACCAAAAGAAACGCCTACACCTCAGAGGAAAGGCCTTCGATC
AAGTGCACTGCGGCCAAAGAGACCAGAAACGCCCAAGCAAACTGGCCCTGTTATTATTGAAACCTGGGTAGCAGAAGAAGAACTGGAATT
GTGGGAGATCAGGGCATTTGCTGAGAGAGTGGAGAAAGAAAAGGCACAAGCAGTTGAGCAACAGGCTAAGAAACGACTGGAGCAGCAGAA
GCCGACAGTGATTGCAACTTCCACTACTTCCCCAACAAGCAGTACAACCAGCACCATCTCTCCAGCACAGAAGGTTATGGTGGCCCCCAT
AAGTGGCTCAGTTACAACTGGAACCAAAATGGTACTAACTACTAAAGTTGGATCTCCAGCTACAGTAACATTCCAACAAAACAAGAACTT
TCATCAAACCTTTGCTACATGGGTTAAGCAAGGCCAGTCAAATTCAGGCGTTGTTCAAGTACAGCAGAAAGTCCTGGGTATCATTCCATC
AAGTACAGGTACCAGTCAGCAAACCTTTACTTCATTCCAGCCCAGGACAGCAACAGTCACAATTAGGCCCAATACCTCAGGCTCTGGAGG
AACCACAAGCAATTCACAAGTAATCACAGGGCCTCAGATTCGCCCTGGTATGACCGTGATTAGAACACCACTCCAACAGTCAACACTAGG
AAAGGCAATTATTCGAACACCTGTGATGGTACAGCCAGGTGCTCCTCAGCAAGTGATGACTCAAATCATCAGGGGGCAGCCTGTCTCCAC
TGCAGTCTCCGCCCCTAACACGGTTTCCTCAACACCTGGGCAGAAAAGCTTAACTTCAGCAACGTCCACTTCAAATATACAGTCTTCAGC
CTCACAACCCCCTCGCCCCCAACAAGGACAAGTGAAGCTCACCATGGCTCAACTTACTCAGTTAACACAGGGCCACGGTGGCAATCAAGG
TTTGACAGTAGTAATTCAAGGACAAGGTCAAACTACTGGACAGTTGCAGTTGATACCTCAAGGGGTGACTGTACTCCCAGGCCCAGGCCA
GCAGCTAATGCAAGCTGCAATGCCAAATGGTACTGTTCAGCGATTCCTCTTTACCCCATTGGCAACAACAGCCACCACAGCCAGCACCAC
CACCACCACTGTTTCCACGACAGCAGCAGGTACAGGTGAACAAAGGCAGAGTAAACTGTCACCCCAGATGCAGGTACATCAAGACAAAAC
CCTGCCACCAGCTCAGTCATCAAGTGTGGGTCCAGCAGAAGCCCAGCCACAGACTGCTCAGCCTTCAGCTCAGCCCCAGCCCCAAACCCA
GCCCCAGTCCCCAGCTCAGCCTGAAGTTCAGACTCAGCCTGAAGTTCAGACCCAAACAACTGTTTCATCCCATGTCCCTTCTGAAGCACA
ACCCACCCACGCACAGTCATCCAAGCCCCAAGTTGCAGCACAGTCTCAGCCTCAAAGTAATGTCCAAGGACAGTCTCCTGTTCGTGTCCA
AAGTCCATCACAGACTCGAATACGTCCATCAACTCCATCCCAACTGTCTCCTGGACAACAATCCCAGGTTCAGACTACAACCTCACAACC
GATTCCAATTCAACCACATACATCTCTTCAGATACCTTCCCAAGGCCAGCCACAGTCACAACCCCAGGTACAGTCTTCAACTCAAACTCT
TTCATCAGGACAAACTTTAAATCAAGTTACTGTTTCATCCCCATCCCGTCCTCAGCTACAAATACAGCAGCCACAGCCCCAAGTCATTGC
TGTGCCTCAGCTGCAACAACAAGTCCAGGTTCTCTCTCAGATCCAGTCACAGGTTGTGGCTCAGATACAGGCTCAGCAAAGTGGTGTGCC
CCAGCAAATCAAACTCCAGTTACCTATCCAAATTCAGCAAAGCAGTGCTGTGCAGACTCACCAGATTCAGAATGTGGTTACAGTGCAGGC
AGCCAGTGTGCAAGAGCAGTTGCAAAGGGTTCAGCAACTCAGGGATCAGCAGCAAAAGAAGAAACAGCAACAGATAGAAATTAAGCGTGA
ACACACCCTCCAAGCTTCTAATCAAAGTGAAATCATTCAGAAACAGGTGGTGATGAAGCATAATGCTGTAATAGAACATTTAAAACAGAA
AAAGAGCATGACTCCAGCTGAAAGAGAAGAGAATCAAAGAATGATTGTCTGTAACCAGGTGATGAAGTATATTTTGGATAAGATAGATAA
AGAAGAAAAACAGGCAGCAAAAAAACGGAAGCGTGAAGAGAGTGTGGAGCAGAAACGTAGCAAGCAGAATGCCACTAAGCTGTCAGCTCT
GCTCTTCAAGCACAAAGAGCAGCTCAGAGCCGAGATCCTGAAGAAGAGAGCACTCCTGGACAAGGATCTGCAAATTGAAGTGCAGGAAGA
GCTGAAGAGAGACCTGAAAATTAAGAAAGAAAAAGACCTGATGCAGTTGGCTCAGGCCACAGCAGTAGCTGCACCCTGCCCCCCAGTGAC
ACCAGCTCCTCCAGCCCCTCCAGCCCCTCCACCTTCACCTCCCCCTCCACCTGCTGTGCAACACACAGGCCTTCTGTCCACGCCCACCTT
ACCTGCTGCTTCCCAGAAGAGGAAGCGGGAAGAGGAAAAAGACTCCAGCTCAAAGTCCAAGAAAAAGAAAATGATCTCTACTACCTCAAA
GGAAACTAAGAAGGACACAAAGCTTTACTGTATCTGTAAAACGCCTTATGATGAATCTAAATTTTATATTGGCTGTGATCGGTGTCAGAA
TTGGTACCATGGGCGCTGCGTTGGCATCTTGCAAAGTGAGGCAGAGCTCATTGATGAGTATGTCTGTCCACAGTGCCAGTCAACAGAGGA
TGCCATGACAGTGCTCACGCCACTAACAGAGAAGGATTATGAGGGGTTGAAGAGGGTGCTCCGTTCCTTACAGGCCCATAAGATGGCCTG
GCCTTTCCTTGAACCAGTAGACCCTAATGATGCACCAGATTATTATGGTGTTATTAAGGAACCTATGGAATCTCGGCGAAGGAGCATCTT
TGAATATCACCGCATAGAGCTGGACCCCAGCAAGGTCACCAGCATGTCGGCCGTGGAGTTCACCCCATTGCCGACCTGCCTGCAGCATAG
GAGCTGTGACGCCTGCATGTCCTCAGACCTGACCTTCAACTGCAGCTGGTGCCATGTCCTCCAGAGATGCTCCAGTGGCTTTGACCGCTA
TCGCCAGGAGTGGATGGACTATGGCTGTGCACAGGAGGCAGAGGGCAGGATGTGCGAGGACTTCCAGGATGAGGACCACGACTCAGCCTC
CCCTGACACTTCCTTCAGCCCCTATGATGGAGACCTCACCACTACCTCCTCCTCCCTCTTCATCGACAGCCTCACCACAGAAGATGACAC
CAAGTTGAATCCCTATGCAGGAGGAGACGGCCTTCAGAACAACCTGTCCCCCAAGACAAAGGGCACTCCTGTGCACCTGGGCACCATCGT
GGGCATCGTGCTGGCAGTCCTCCTCGTGGCGGCCATCATCCTGGCTGGAATTTACATCAATGGCCACCCCACATCCAATGCTGCGCTCTT
CTTCATCGAGCGTAGACCTCACCACTGGCCAGCCATGAAGTTTCGCAGCCACCCTGACCATTCCACCTATGCGGAGGTGGAGCCCTCGGG
CCATGAGAAGGAGGGCTTCATGGAGGCTGAGCAGTGCTGAGAACACCAAGTCTCCCCTTTGAAGACTTTGAGGCCACAGAAAAGACAGTT
AAAGCAAAGAAGAGAAGTGACTTTTCCTGGCCTCTCCCAGCATGCCCTGGGCTGAGATGAGATGGTGGTTTATGGCTCCAGAGCTGCTGC
TCGCTTCGTCAGCACACCCCGAATATTGAAGAGGGGGCCAAAAAACAACCACATGGATTTTTTATAGGAACAACAACCTAATCTCATCCT
GTTTTGATGCAAGGGTTCTCTTCTGTGTCTTGTAACCATGAAACAGCAGAAGAACTAACATAACTAACTCCATTTTTGTTTAAGGGGCCT
TTACCTATTCCTGCACCTAGGCTAGGATAACTTTAGAGCACTGACATAAAACGCAAAAACAGGAATCATGCCGTTTGCAAAACTAACTCT
GGGATTAAAGGGGAAGCATGTAAACAGCTAACTGTTTTTGTTAAAGATTTATAGGAATGAGGAGGTTTGGCTATTGTCACATGACAGACT
GTTAGCCAAGGACAAAGAAGTTCTGCAAACCTCCCCTGGACCCTTGCTGGTGTCCAGATGTCTGCGGTTGTCAGCCCCTTCCTTTCCCCC
GACCTAAACATAAAAGACAAGGCAAAGCCCGCATAATTTTAAGACGGTTCTTTAGGACATTAGTCCACCATCTTCTTGGTTTGCTGGCTC
TCCGAAATAAAGTCCCTTTCCTTGCTCCAACTCCTTGTCTCTCAACGTATTGGCTATGACGCAGCAAGCAGAATGAATTTGGACTCAGTT
ACAGGCTGTCAATGGTCTGCTCTGTAGCAGTCTCAGAGCCTCCCCGACCCACTACCTGGAGATAGCCAGATAGCCAGATGCCCTGCTCCT
GGCCACCTTTAAAGCCCCTGCATATGACACAGGTTAACTAAAGTCAAGATTGGGGCTGCTGCATTCCAGGTTCCCTAGACTCACAAGCTG
GTCCTTGGCCAGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACCTGAAGTCAGAAGTTTGAGA
CCAGCCTGGCCAACATAATTAAAATGTCTCTACTAAAAATACAAAAAATTAGCTGGGTGTGGTGACGCTTGCCTGTATCCCAGCTACTCA
GGAAGCTGAGACACGAGAATCACTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCTCAGATAGTGCCACTGCACTCCAGCCTGGGTGACAG
AGCGAGACTCCGTCTCAAAAAAAAAAAAAGAAAGCAGATCCTCATGGCTATAGAGTTGGCATTTTAGCCCCAGCTTCTGTAGCTCTGAAA
GCCTAAAGAAGGTATTCTCTCCATCTGTTAAACACAGTATAGTGGCTCTCAGCCCTTGGGGCATGTTATCATGGGAGGGAAGTCAAATAA
GAGGAGAGAAAAGAACTCAAGGGGGAAACTGCATTTTTAGGCTTTGCTCTCTTACCTTGCCCTTTCTACTCAGAACCAATAACTTCTGCA
TCAAAACATGTTACAGCCTGCATCAAGGGCTTTACCCCAACCTGCAGCCCAGCCTTCCCTGGGTGAGCTTGCTATGCGCAGCCACATTTA
CCATGTGGGGCTCCCTATTCTGATGGCCTGTTCGGTGCCGGGTTTACTCACTGCCCTGTTCTGATGTCAGTGCCTGTACATACCTCCAAA
GGCAGGACTTGCCTGATAAATATTTTTCCTCCTCTGAACTGGATTTTATAGGCATTAAAGACAAGTCGGGTGGCTAGAGGGCTCCTTGAG
ACATACCTAGCAGGGAACTGCAGGTGGATTCTGTTGAGAGGCAAAGCACCTGAGTGGTTGGGACACAGGCAGCTGGCATGGGAGGGACTT
TTTTTGAGACAGGGTCTCACTGTGTCGCCCAGGGCAAGGATGCCCAAAGACACCAGGTTGGAGAGGCACCTGCCAACTACTTGCTTTCCC
TGGAGCCTGCATGTGCCTGTGGGGTGGGGAGGCGTAGGGGTCTACGGCTGCCTGAGATGGGTGTGCACAGTGTGTGAAGTACCTACCTCC
TTGCCTTGCTGGACTGTCAGCCAGTCGCAGGGCCGGCCACAAGACCCATGTCTCCATCTGGTCATACTCCATAGCTACCAAGTTAACCTG
CTCTAAACTTTGGAGAACTGGATCTGTCCAATAAACGCTTATTTGGCCAAGCCTGATGGCTCGTGCCTGTACTCCCAGCACTTTGGGAGG
CTGAGGTGGGAGGGTTGCTTGAGCCCAGGGGTTTGAGACCAGCTTGGGCAACAACAACAAAAATGCCAGGTGTGGTGGGGTGCACCTGTA
GTCCCAGCTACTAGGGAGGCTGAGCCAGGAGGATCACTTGAGCCCGGGAGGTTGAGGCTGCAGTGGGGGGTCATAATCATGCCACTGTAC
TCCAGCCTGGGTGACAGAGTGAGACCCTGTCTCCGAAAAAAAAAAAAAAAAAAAGAACGGAAAAAGAAATGCTTACATTGTCAGGGATCC
TGTAGACAATCATTAACTCTATGAGATGCTTGGTTCTATTTTTTTGGGAGACTTTGTCCAAGTGTTTTGGCTTAAGAAATCCATAGGCCT
CTCTTGGTGACACATCTCTAGTACTTTTTGTCATAAACAAACAGGCCATCTGCCGCCAAATACATCCACTCCCCATGCCACTGACATCCT
ATGGGTCAGCCAGGCTTGCTTTGACTGAGGCCGAGGCATCTGGAACTTTCTCTGCCTGCAGGGGCTAGCAGCAGAGGCTTCACCGCATCA
CCACCCCTTCCTCCACTCCTGACATTCTTTCCCTTCAGGGATCCAAAATGGTTGGCCGAGCTCCCAGTGGGAAAACGTGTGCTAGAGTTG
GGGAGTGAGATGAGTGGTGCTGTCCATGGAATCAGGCCACAGCAGGAACTGCCCCACTGGCCATTTGAGACACACACAGGTGGTAAATGC
TCTGCTGGTGGGCTGTGCTTCCCTCATTCAGAGAGCTCTGTTACAGCCCACTGTGTCCTTTAGAAGCTTGAAAGGAACCCAACTCTTTGC
TGCACTGTCCTTTTTCTTCCTCAAATTCAGACCCTCCTTCCACCGGCACCCCCCTACTCCACCCTCAGCTCTTCCTTGCCTGGTTTATCA
AGCAGAGCTGAGGCCCCACGTTTCCAACTCTGATTGTCACTTGCATCTTCACAAAGGATAAACCACGGAGCAACTGGAAAACCATCAGCC
AAGCGTTCGGATGAGTCTGGTTATTGGTCCACCCCCGACCAGATTCCCTTACACTTAACTCACTTCTTTCTTTGGCAATGACCCTCATGA
CATGTATAAATGGGTATGACTAAGAAGAGGCTGTGATCTAACATTTATTTGCTGCCATTTTTTACTCTGGGGAGAAGCAGCCCCAACTCA
TCACTGGGAAAGAACTCCCCCTGCAAACCAGCTAAATTTGATAATTTAAACCCCCTGCCCCTAAAACTTCTCACAGAGCTGGGGAGTTGG
TGGCAACTTTCCAAGTCAAGGTCTTGCTTAGAAAGTCCTTCACTACATGGCCAGGTGCAGTGGCTCACGCCTGTAGTCCCAGGTACTTGG
GAGCCTGAGGCAGGAGGATTGCTTGAGCTCAGGAGTTCAAGGCTGCAGAGAGCTATGATCATCCCACTGCATTTGTTTAAAAATAAATTT
TTAAAATTTGTGTGTTTTATCAGGGGTCTCCTGTACAGTGTATCTGTGTATGTTTGTGTGTGTGTTTGTATACAGCCTTGTTTAATGTTT
TGAGCAATAAGATATGCACACACAGGTATTTTGTTGCTAAAGAGATTGGACAAGGTTGTAGCTGTGCTCAGGCTTCAGCTTGGTTTGTTA
AATTGAGAGATAAACAATGACAAGAGCTGCCAGCCAACCACACTATTCAAAAAGCAAAGTGTTCACCACTAAAGCTAACCATTCATCTGG
TTGCAGGCAAGGCTAAGGCTCTCTCTCCTCTAGTTCCTGGAACAGACTCACAGATTGGCATGAAGCACTGATCAGGGGCTGCACTCAGAC
TCCCTGGCCAAGCAAACCTACACCAGAAGAGTCAGTGTCACAGATATGATGCGGCCAATCTCTGTCTCCAAAAACCTACCTGAACTTAAT
GGTAGAATTCAAAGATCTGGGGACTGAGGGCACCCAGCCTTCTAAAACACAATGTATTCATGTGTTTAGTGTAAACTCTCTGCATGGATT
CTCAGTGTTAATAATAAAAGGAAGCATTCTTTTACAACTCCTGCTGTGTGCAAAAGAAAGTGCAAAGGATTTGGAGTGGCATTCCGAAGA
TCACCACACATACCTTGGTTCTGATGGCTGCTGAACTCCGACTTCTTCGCTGAGACATGACTGTGGGAACAGCCTCCAGCTATCTGCTCA
TCAGAGGTGCTTTCCTCAACCTCCTGCACCACCTCCAAGAGAAACAGCCTAAAAAGAAACCCCAGCTGTTTACTTATATTGGTCTGTAAA

>10098_10098_2_BPTF-PLXDC1_BPTF_chr17_65962772_ENST00000321892_PLXDC1_chr17_37243955_ENST00000315392_length(amino acids)=3202AA_BP=0
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGRRKPRVHRPRSPILEEKDIPPLEFPKSSEDLMVPNEHIMNVIAIYEVLRNFGTVLRLSPFRFEDF
CAALVSQEQCTLMAEMHVVLLKAVLREEDTSNTTFGPADLKDSVNSTLYFIDGMTWPEVLRVYCESDKEYHHVLPYQEAEDYPYGPVENK
IKVLQFLVDQFLTTNIAREELMSEGVIQYDDHCRVCHKLGDLLCCETCSAVYHLECVKPPLEEVPEDEWQCEVCVAHKVPGVTDCVAEIQ
KNKPYIRHEPIGYDRSRRKYWFLNRRLIIEEDTENENEKKIWYYSTKVQLAELIDCLDKDYWEAELCKILEEMREEIHRHMDITEDLTNK
ARGSNKSFLAAANEEILESIRAKKGDIDNVKSPEETEKDKNETENDSKDAEKNREEFEDQSLEKDSDDKTPDDDPEQGKSEEPTEVGDKG
NSVSANLGDNTTNATSEETSPSEGRSPVGCLSETPDSSNMAEKKVASELPQDVPEEPNKTCESSNTSATTTSIQPNLENSNSSSELNSSQ
SESAKAADDPENGERESHTPVSIQEEIVGDFKSEKSNGELSESPGAGKGASGSTRIITRLRNPDSKLSQLKSQQVAAAAHEANKLFKEGK
EVLVVNSQGEISRLSTKKEVIMKGNINNYFKLGQEGKYRVYHNQYSTNSFALNKHQHREDHDKRRHLAHKFCLTPAGEFKWNGSVHGSKV
LTISTLRLTITQLENNIPSSFLHPNWASHRANWIKAVQMCSKPREFALALAILECAVKPVVMLPIWRESLGHTRLHRMTSIEREEKEKVK
KKEKKQEEEETMQQATWVKYTFPVKHQVWKQKGEEYRVTGYGGWSWISKTHVYRFVPKLPGNTNVNYRKSLEGTKNNMDENMDESDKRKC
SRSPKKIKIEPDSEKDEVKGSDAAKGADQNEMDISKITEKKDQDVKELLDSDSDKPCKEEPMEVDDDMKTESHVNCQESSQVDVVNVSEG
FHLRTSYKKKTKSSKLDGLLERRIKQFTLEEKQRLEKIKLEGGIKGIGKTSTNSSKNLSESPVITKAKEGCQSDSMRQEQSPNANNDQPE
DLIQGCSESDSSVLRMSDPSHTTNKLYPKDRVLDDVSIRSPETKCPKQNSIENDIEEKVSDLASRGQEPSKSKTKGNDFFIDDSKLASAD
DIGTLICKNKKPLIQEESDTIVSSSKSALHSSVPKSTNDRDATPLSRAMDFEGKLGCDSESNSTLENSSDTVSIQDSSEEDMIVQNSNES
ISEQFRTREQDVEVLEPLKCELVSGESTGNCEDRLPVKGTEANGKKPSQQKKLEERPVNKCSDQIKLKNTTDKKNNENRESEKKGQRTST
FQINGKDNKPKIYLKGECLKEISESRVVSGNVEPKVNNINKIIPENDIKSLTVKESAIRPFINGDVIMEDFNERNSSETKSHLLSSSDAE
GNYRDSLETLPSTKESDSTQTTTPSASCPESNSVNQVEDMEIETSEVKKVTSSPITSEEESNLSNDFIDENGLPINKNENVNGESKRKTV
ITEVTTMTSTVATESKTVIKVEKGDKQTVVSSTENCAKSTVTTTTTTVTKLSTPSTGGSVDIISVKEQSKTVVTTTVTDSLTTTGGTLVT
SMTVSKEYSTRDKVKLMKFSRPKKTRSGTALPSYRKFVTKSSKKSIFVLPNDDLKKLARKGGIREVPYFNYNAKPALDIWPYPSPRPTFG
ITWRYRLQTVKSLAGVSLMLRLLWASLRWDDMAAKAPPGGGTTRTETSETEITTTEIIKRRDVGPYGIRSEYCIRKIICPIGVPETPKET
PTPQRKGLRSSALRPKRPETPKQTGPVIIETWVAEEELELWEIRAFAERVEKEKAQAVEQQAKKRLEQQKPTVIATSTTSPTSSTTSTIS
PAQKVMVAPISGSVTTGTKMVLTTKVGSPATVTFQQNKNFHQTFATWVKQGQSNSGVVQVQQKVLGIIPSSTGTSQQTFTSFQPRTATVT
IRPNTSGSGGTTSNSQVITGPQIRPGMTVIRTPLQQSTLGKAIIRTPVMVQPGAPQQVMTQIIRGQPVSTAVSAPNTVSSTPGQKSLTSA
TSTSNIQSSASQPPRPQQGQVKLTMAQLTQLTQGHGGNQGLTVVIQGQGQTTGQLQLIPQGVTVLPGPGQQLMQAAMPNGTVQRFLFTPL
ATTATTASTTTTTVSTTAAGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTT
VSSHVPSEAQPTHAQSSKPQVAAQSQPQSNVQGQSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQ
PQVQSSTQTLSSGQTLNQVTVSSPSRPQLQIQQPQPQVIAVPQLQQQVQVLSQIQSQVVAQIQAQQSGVPQQIKLQLPIQIQQSSAVQTH
QIQNVVTVQAASVQEQLQRVQQLRDQQQKKKQQQIEIKREHTLQASNQSEIIQKQVVMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQV
MKYILDKIDKEEKQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAEILKKRALLDKDLQIEVQEELKRDLKIKKEKDLMQLAQAT
AVAAPCPPVTPAPPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKRKREEEKDSSSKSKKKKMISTTSKETKKDTKLYCICKTPYDESK
FYIGCDRCQNWYHGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVLRSLQAHKMAWPFLEPVDPNDAPDYYGVIKE
PMESRRRSIFEYHRIELDPSKVTSMSAVEFTPLPTCLQHRSCDACMSSDLTFNCSWCHVLQRCSSGFDRYRQEWMDYGCAQEAEGRMCED
FQDEDHDSASPDTSFSPYDGDLTTTSSSLFIDSLTTEDDTKLNPYAGGDGLQNNLSPKTKGTPVHLGTIVGIVLAVLLVAAIILAGIYIN

--------------------------------------------------------------
>10098_10098_3_BPTF-PLXDC1_BPTF_chr17_65962772_ENST00000335221_PLXDC1_chr17_37243955_ENST00000315392_length(transcript)=13778nt_BP=8549nt
CGCCCCCCCTGCGCCCGCCCCTCCCCCTTCGCTTTCCTTCTCCCCCCGCCTCGGCTCCGACATGAGGGGCCGGCGGGGCAGGCCGCCCAA
GCAGCCCGCGGCTCCCGCTGCGGAGCGCTGCGCCCCGGCCCCGCCGCCACCGCCGCCGCCGCCCACGTCCGGACCCATCGGGGGGCTCCG
CTCGCGGCACCGCGGCAGCAGCCGGGGCAGGTGGGCCGCCGCCCAGGCTGAGGTGGCGCCCAAGACGCGGCTGAGCTCGCCCAGGGGGGG
CAGCAGTAGCCGGAGGAAGCCGCCGCCGCCGCCGCCGGCCCCCCCCAGCACCAGCGCCCCGGGCCGGGGGGGGCGAGGAGGCGGGGGCGG
CAGGACGGGGGGCGGGGGCGGCGGCGGCCACCTGGCCCGGACCACCGCGGCCCGGAGGGCCGTCAACAAAGTGGTGTACGATGACCACGA
GAGCGAGGAGGAGGAGGAAGAGGAGGACATGGTCTCCGAGGAGGAGGAGGAGGAGGACGGCGACGCCGAGGAGACCCAGGATTCTGAGGA
CGACGAGGAGGATGAGATGGAAGAGGACGACGATGACTCCGATTATCCGGAGGAGATGGAAGACGACGACGACGACGCCAGTTACTGCAC
GGAAAGCAGCTTCAGGAGCCATAGTACCTACAGCAGCACTCCAGGTAGGCGAAAACCAAGAGTACATCGGCCTCGTTCTCCTATATTGGA
AGAAAAAGACATCCCGCCCCTTGAATTTCCCAAGTCCTCTGAGGATTTAATGGTGCCTAATGAGCATATAATGAATGTCATTGCCATTTA
CGAGGTACTGCGGAACTTTGGCACTGTTTTGAGATTATCTCCTTTTCGCTTTGAGGACTTTTGTGCAGCTCTGGTGAGCCAAGAGCAGTG
CACACTCATGGCAGAGATGCATGTTGTGCTTTTGAAAGCAGTTCTGCGTGAAGAAGACACTTCCAATACTACCTTTGGACCTGCTGATCT
GAAAGATAGCGTTAATTCCACACTGTATTTCATAGATGGGATGACGTGGCCAGAGGTGCTGCGGGTGTACTGTGAGAGTGATAAGGAGTA
CCATCACGTTCTTCCTTACCAAGAGGCAGAGGACTACCCATATGGACCAGTAGAGAACAAGATCAAAGTTCTACAGTTTCTAGTCGATCA
GTTTCTTACAACAAATATTGCTCGAGAGGAATTGATGTCTGAAGGGGTGATACAGTATGATGACCATTGTAGGGTTTGTCACAAACTTGG
GGATTTGCTTTGCTGTGAGACATGTTCAGCAGTATACCATTTGGAATGTGTGAAGCCACCTCTTGAGGAGGTGCCAGAGGACGAGTGGCA
GTGTGAAGTCTGTGTAGCACACAAGGTGCCTGGTGTGACTGACTGTGTTGCTGAAATCCAAAAAAATAAACCATATATTCGACATGAACC
TATTGGATATGATAGAAGTCGGAGGAAATACTGGTTCTTGAACCGAAGACTCATAATAGAAGAAGATACAGAAAATGAAAATGAAAAGAA
AATTTGGTATTACAGCACAAAGGTCCAACTTGCAGAATTAATTGACTGTCTAGACAAAGATTATTGGGAAGCAGAACTCTGCAAAATTCT
AGAAGAAATGCGTGAAGAAATCCACCGACACATGGACATAACTGAAGACCTGACCAATAAGGCTCGGGGCAGTAACAAATCCTTTCTGGC
GGCAGCTAATGAAGAAATTTTGGAATCCATAAGAGCCAAAAAGGGAGACATTGATAATGTTAAAAGCCCAGAAGAAACAGAAAAAGACAA
GAATGAGACTGAGAATGACTCTAAAGATGCTGAGAAAAACAGAGAAGAATTTGAAGACCAGTCCCTTGAAAAAGACAGTGACGACAAAAC
ACCAGATGATGACCCTGAGCAAGGAAAATCTGAGGAGCCAACAGAAGTTGGGGATAAAGGTAACTCTGTGTCAGCAAATCTTGGCGACAA
CACAACAAATGCAACTTCAGAAGAGACTAGTCCCTCTGAAGGGAGGAGCCCTGTGGGGTGTCTCTCAGAAACCCCCGATAGCAGCAACAT
GGCAGAGAAGAAGGTGGCATCTGAGCTCCCCCAGGATGTGCCAGAAGAACCTAACAAGACATGTGAGAGCAGTAACACTAGTGCTACCAC
TACCTCCATCCAGCCTAATCTGGAAAACAGTAACAGCAGCAGTGAACTAAATTCTTCCCAGAGTGAATCTGCTAAGGCAGCTGATGATCC
TGAAAATGGAGAAAGAGAATCTCATACACCTGTCTCTATTCAGGAAGAGATAGTAGGTGATTTCAAATCGGAGAAGTCCAACGGGGAGCT
AAGTGAATCTCCTGGAGCTGGAAAAGGAGCATCTGGCTCAACTCGAATCATCACCAGATTGCGGAATCCAGATAGCAAACTTAGTCAGCT
GAAGAGCCAGCAGGTGGCAGCCGCTGCACATGAAGCAAATAAATTATTTAAGGAGGGCAAAGAGGTACTGGTAGTTAACTCTCAAGGAGA
AATTTCACGGTTGAGCACCAAAAAGGAAGTGATCATGAAAGGAAATATCAACAATTATTTTAAATTGGGTCAAGAAGGGAAGTATCGCGT
CTACCACAATCAATACTCCACCAATTCATTTGCTTTGAATAAGCACCAGCACAGAGAAGACCATGATAAGAGAAGGCATCTTGCACATAA
GTTCTGTCTGACTCCAGCAGGAGAGTTCAAATGGAACGGTTCTGTCCATGGGTCCAAAGTTCTTACCATATCTACTCTGAGACTGACTAT
CACCCAATTAGAAAACAACATCCCTTCATCCTTTCTTCATCCCAACTGGGCATCACATAGGGCAAATTGGATCAAGGCAGTTCAGATGTG
TAGCAAACCCAGAGAATTTGCATTGGCTTTAGCCATTTTGGAGTGTGCAGTTAAACCAGTTGTGATGCTACCAATATGGCGAGAATCTTT
AGGACATACCAGGTTACACCGGATGACATCAATTGAAAGAGAAGAAAAGGAGAAAGTCAAAAAAAAAGAGAAGAAACAGGAAGAAGAAGA
AACGATGCAGCAAGCGACATGGGTAAAATACACATTTCCAGTTAAGCATCAGGTTTGGAAACAAAAAGGTGAAGAGTACAGAGTGACAGG
ATATGGTGGTTGGAGCTGGATTAGTAAAACTCATGTTTATAGGTTTGTTCCTAAATTGCCAGGCAATACTAATGTGAATTACAGAAAGTC
GTTAGAAGGAACCAAAAATAATATGGATGAAAATATGGATGAGTCAGATAAAAGAAAATGTTCACGAAGTCCAAAAAAAATAAAAATAGA
GCCTGATTCTGAAAAAGATGAGGTAAAAGGTTCAGATGCTGCAAAAGGAGCAGACCAAAATGAAATGGATATCTCAAAGATTACTGAGAA
GAAGGACCAAGATGTGAAGGAGCTCTTAGATTCTGACAGTGATAAACCCTGCAAGGAAGAACCAATGGAAGTAGACGATGACATGAAAAC
AGAGTCACATGTAAATTGTCAGGAGAGTTCTCAAGTAGATGTGGTCAATGTTAGTGAGGGTTTTCATCTAAGGACTAGTTACAAAAAGAA
AACAAAATCATCCAAACTAGATGGACTTCTTGAAAGGAGAATTAAACAGTTTACACTGGAAGAAAAACAGCGACTCGAAAAAATCAAGTT
GGAGGGTGGAATTAAGGGTATAGGAAAGACTTCTACAAATTCTTCAAAAAATCTCTCTGAATCACCAGTAATAACGAAAGCAAAAGAAGG
GTGTCAGAGTGACTCGATGAGACAAGAACAGAGCCCAAATGCAAATAATGATCAACCTGAGGACTTGATTCAGGGATGTTCAGAAAGTGA
TTCCTCAGTTCTTAGAATGAGTGATCCTAGTCATACCACAAACAAACTTTATCCAAAAGATCGAGTGTTAGATGATGTCTCCATTCGGAG
CCCAGAAACAAAATGTCCGAAACAAAATTCCATTGAAAATGACATAGAAGAAAAAGTCTCTGACCTTGCCAGTAGAGGCCAGGAACCCAG
TAAGAGTAAAACAAAAGGAAATGATTTTTTCATCGATGACTCTAAACTAGCCAGTGCAGATGATATTGGTACTTTGATCTGTAAGAACAA
AAAACCGCTCATACAGGAGGAAAGTGACACCATTGTTTCTTCTTCCAAGAGTGCTTTACATTCATCAGTGCCTAAAAGTACCAATGACAG
AGATGCCACACCTCTGTCAAGAGCAATGGACTTTGAAGGAAAACTGGGATGTGACTCTGAATCTAATAGCACTTTGGAAAATAGTTCTGA
TACCGTGTCTATTCAGGATAGCAGTGAAGAAGATATGATTGTTCAGAATAGCAATGAAAGCATTTCTGAACAGTTCAGAACTCGAGAACA
AGATGTTGAAGTCTTGGAGCCGTTAAAGTGTGAGTTGGTTTCTGGTGAGTCCACTGGAAACTGTGAGGACAGGCTGCCGGTCAAGGGGAC
TGAAGCAAATGGTAAAAAACCAAGTCAGCAGAAGAAATTAGAGGAGAGACCAGTTAATAAATGTAGTGATCAAATAAAGCTAAAAAATAC
CACTGACAAAAAGAATAATGAAAATCGAGAGTCTGAAAAGAAAGGACAGAGAACAAGTACATTTCAAATAAATGGAAAAGATAATAAACC
CAAAATATATTTGAAAGGTGAATGCTTGAAAGAAATTTCTGAGAGTAGAGTAGTAAGTGGTAATGTTGAACCAAAGGTTAATAATATAAA
TAAAATAATCCCTGAGAATGATATTAAATCATTGACTGTTAAAGAATCTGCTATAAGGCCATTCATTAATGGTGATGTCATCATGGAAGA
TTTTAATGAAAGAAACAGCTCCGAAACAAAATCGCATTTGCTGAGTTCTTCAGATGCTGAAGGTAACTACCGAGATAGCCTTGAGACCCT
GCCATCAACCAAAGAGTCTGACAGTACACAGACGACCACACCCTCAGCATCTTGTCCAGAAAGCAATTCAGTTAATCAGGTAGAAGATAT
GGAAATAGAAACCTCAGAAGTTAAGAAAGTTACTTCATCACCTATTACTTCTGAAGAGGAATCTAATCTCAGTAATGACTTTATTGATGA
AAATGGTCTGCCCATCAACAAAAATGAAAATGTCAATGGAGAATCTAAAAGAAAAACCGTCATCACAGAAGTCACCACGATGACCTCCAC
AGTGGCCACAGAATCAAAAACTGTGATCAAGGTAGAAAAAGGCGATAAGCAAACTGTGGTTTCTTCCACAGAAAATTGTGCAAAATCCAC
TGTCACAACCACCACTACAACAGTGACCAAGCTTTCCACACCCTCCACAGGCGGCAGTGTGGACATCATCTCTGTAAAGGAGCAGAGCAA
AACCGTGGTCACCACGACAGTGACAGACTCCCTGACCACCACGGGAGGCACACTGGTTACATCTATGACTGTGAGCAAAGAGTATTCCAC
ACGAGACAAAGTGAAACTGATGAAATTTTCAAGACCAAAGAAGACTCGTTCAGGTACAGCTCTGCCATCCTATAGAAAATTTGTTACCAA
GAGCAGCAAGAAGAGCATTTTTGTTTTGCCTAATGATGACTTAAAAAAGTTGGCCCGAAAAGGAGGAATCCGAGAGGTCCCTTATTTTAA
TTACAATGCAAAACCTGCTTTGGATATATGGCCATATCCTTCTCCTAGACCGACCTTTGGCATCACTTGGAGGTATAGACTTCAGACAGT
AAAGTCCTTAGCTGGAGTGAGCCTGATGTTACGGTTACTGTGGGCAAGTTTGAGATGGGATGATATGGCGGCCAAGGCTCCTCCAGGAGG
AGGGACTACACGGACAGAAACATCCGAAACTGAAATCACAACAACAGAAATAATTAAGAGGAGAGATGTTGGTCCTTATGGCATTCGATC
TGAATATTGTATCAGGAAAATCATTTGTCCCATTGGAGTTCCAGAAACACCAAAAGAAACGCCTACACCTCAGAGGAAAGGCCTTCGATC
AAGTGCACTGCGGCCAAAGAGACCAGAAACGCCCAAGCAAACTGGCCCTGTTATTATTGAAACCTGGGTAGCAGAAGAAGAACTGGAATT
GTGGGAGATCAGGGCATTTGCTGAGAGAGTGGAGAAAGAAAAGGCACAAGCAGTTGAGCAACAGGCTAAGAAACGACTGGAGCAGCAGAA
GCCGACAGTGATTGCAACTTCCACTACTTCCCCAACAAGCAGTACAACCAGCACCATCTCTCCAGCACAGAAGGTTATGGTGGCCCCCAT
AAGTGGCTCAGTTACAACTGGAACCAAAATGGTACTAACTACTAAAGTTGGATCTCCAGCTACAGTAACATTCCAACAAAACAAGAACTT
TCATCAAACCTTTGCTACATGGGTTAAGCAAGGCCAGTCAAATTCAGGCGTTGTTCAAGTACAGCAGAAAGTCCTGGGTATCATTCCATC
AAGTACAGGTACCAGTCAGCAAACCTTTACTTCATTCCAGCCCAGGACAGCAACAGTCACAATTAGGCCCAATACCTCAGGCTCTGGAGG
AACCACAAGCAATTCACAAGTAATCACAGGGCCTCAGATTCGCCCTGGTATGACCGTGATTAGAACACCACTCCAACAGTCAACACTAGG
AAAGGCAATTATTCGAACACCTGTGATGGTACAGCCAGGTGCTCCTCAGCAAGTGATGACTCAAATCATCAGGGGGCAGCCTGTCTCCAC
TGCAGTCTCCGCCCCTAACACGGTTTCCTCAACACCTGGGCAGAAAAGCTTAACTTCAGCAACGTCCACTTCAAATATACAGTCTTCAGC
CTCACAACCCCCTCGCCCCCAACAAGGACAAGTGAAGCTCACCATGGCTCAACTTACTCAGTTAACACAGGGCCACGGTGGCAATCAAGG
TTTGACAGTAGTAATTCAAGGACAAGGTCAAACTACTGGACAGTTGCAGTTGATACCTCAAGGGGTGACTGTACTCCCAGGCCCAGGCCA
GCAGCTAATGCAAGCTGCAATGCCAAATGGTACTGTTCAGCGATTCCTCTTTACCCCATTGGCAACAACAGCCACCACAGCCAGCACCAC
CACCACCACTGTTTCCACGACAGCAGCAGGTACAGGTGAACAAAGGCAGAGTAAACTGTCACCCCAGATGCAGGTACATCAAGACAAAAC
CCTGCCACCAGCTCAGTCATCAAGTGTGGGTCCAGCAGAAGCCCAGCCACAGACTGCTCAGCCTTCAGCTCAGCCCCAGCCCCAAACCCA
GCCCCAGTCCCCAGCTCAGCCTGAAGTTCAGACTCAGCCTGAAGTTCAGACCCAAACAACTGTTTCATCCCATGTCCCTTCTGAAGCACA
ACCCACCCACGCACAGTCATCCAAGCCCCAAGTTGCAGCACAGTCTCAGCCTCAAAGTAATGTCCAAGGACAGTCTCCTGTTCGTGTCCA
AAGTCCATCACAGACTCGAATACGTCCATCAACTCCATCCCAACTGTCTCCTGGACAACAATCCCAGGTTCAGACTACAACCTCACAACC
GATTCCAATTCAACCACATACATCTCTTCAGATACCTTCCCAAGGCCAGCCACAGTCACAACCCCAGGTGGTGATGAAGCATAATGCTGT
AATAGAACATTTAAAACAGAAAAAGAGCATGACTCCAGCTGAAAGAGAAGAGAATCAAAGAATGATTGTCTGTAACCAGGTGATGAAGTA
TATTTTGGATAAGATAGATAAAGAAGAAAAACAGGCAGCAAAAAAACGGAAGCGTGAAGAGAGTGTGGAGCAGAAACGTAGCAAGCAGAA
TGCCACTAAGCTGTCAGCTCTGCTCTTCAAGCACAAAGAGCAGCTCAGAGCCGAGATCCTGAAGAAGAGAGCACTCCTGGACAAGGATCT
GCAAATTGAAGTGCAGGAAGAGCTGAAGAGAGACCTGAAAATTAAGAAAGAAAAAGACCTGATGCAGTTGGCTCAGGCCACAGCAGTAGC
TGCACCCTGCCCCCCAGTGACACCAGCTCCTCCAGCCCCTCCAGCCCCTCCACCTTCACCTCCCCCTCCACCTGCTGTGCAACACACAGG
CCTTCTGTCCACGCCCACCTTACCTGCTGCTTCCCAGAAGAGGAAGCGGGAAGAGGAAAAAGACTCCAGCTCAAAGTCCAAGAAAAAGAA
AATGATCTCTACTACCTCAAAGGAAACTAAGAAGGACACAAAGCTTTACTGTATCTGTAAAACGCCTTATGATGAATCTAAATTTTATAT
TGGCTGTGATCGGTGTCAGAATTGGTACCATGGGCGCTGCGTTGGCATCTTGCAAAGTGAGGCAGAGCTCATTGATGAGTATGTCTGTCC
ACAGTGCCAGTCAACAGAGGATGCCATGACAGTGCTCACGCCACTAACAGAGAAGGATTATGAGGGGTTGAAGAGGGTGCTCCGTTCCTT
ACAGGCCCATAAGATGGCCTGGCCTTTCCTTGAACCAGTAGACCCTAATGATGCACCAGATTATTATGGTGTTATTAAGGAACCTATGGA
ATCTCGGCGAAGGAGCATCTTTGAATATCACCGCATAGAGCTGGACCCCAGCAAGGTCACCAGCATGTCGGCCGTGGAGTTCACCCCATT
GCCGACCTGCCTGCAGCATAGGAGCTGTGACGCCTGCATGTCCTCAGACCTGACCTTCAACTGCAGCTGGTGCCATGTCCTCCAGAGATG
CTCCAGTGGCTTTGACCGCTATCGCCAGGAGTGGATGGACTATGGCTGTGCACAGGAGGCAGAGGGCAGGATGTGCGAGGACTTCCAGGA
TGAGGACCACGACTCAGCCTCCCCTGACACTTCCTTCAGCCCCTATGATGGAGACCTCACCACTACCTCCTCCTCCCTCTTCATCGACAG
CCTCACCACAGAAGATGACACCAAGTTGAATCCCTATGCAGGAGGAGACGGCCTTCAGAACAACCTGTCCCCCAAGACAAAGGGCACTCC
TGTGCACCTGGGCACCATCGTGGGCATCGTGCTGGCAGTCCTCCTCGTGGCGGCCATCATCCTGGCTGGAATTTACATCAATGGCCACCC
CACATCCAATGCTGCGCTCTTCTTCATCGAGCGTAGACCTCACCACTGGCCAGCCATGAAGTTTCGCAGCCACCCTGACCATTCCACCTA
TGCGGAGGTGGAGCCCTCGGGCCATGAGAAGGAGGGCTTCATGGAGGCTGAGCAGTGCTGAGAACACCAAGTCTCCCCTTTGAAGACTTT
GAGGCCACAGAAAAGACAGTTAAAGCAAAGAAGAGAAGTGACTTTTCCTGGCCTCTCCCAGCATGCCCTGGGCTGAGATGAGATGGTGGT
TTATGGCTCCAGAGCTGCTGCTCGCTTCGTCAGCACACCCCGAATATTGAAGAGGGGGCCAAAAAACAACCACATGGATTTTTTATAGGA
ACAACAACCTAATCTCATCCTGTTTTGATGCAAGGGTTCTCTTCTGTGTCTTGTAACCATGAAACAGCAGAAGAACTAACATAACTAACT
CCATTTTTGTTTAAGGGGCCTTTACCTATTCCTGCACCTAGGCTAGGATAACTTTAGAGCACTGACATAAAACGCAAAAACAGGAATCAT
GCCGTTTGCAAAACTAACTCTGGGATTAAAGGGGAAGCATGTAAACAGCTAACTGTTTTTGTTAAAGATTTATAGGAATGAGGAGGTTTG
GCTATTGTCACATGACAGACTGTTAGCCAAGGACAAAGAAGTTCTGCAAACCTCCCCTGGACCCTTGCTGGTGTCCAGATGTCTGCGGTT
GTCAGCCCCTTCCTTTCCCCCGACCTAAACATAAAAGACAAGGCAAAGCCCGCATAATTTTAAGACGGTTCTTTAGGACATTAGTCCACC
ATCTTCTTGGTTTGCTGGCTCTCCGAAATAAAGTCCCTTTCCTTGCTCCAACTCCTTGTCTCTCAACGTATTGGCTATGACGCAGCAAGC
AGAATGAATTTGGACTCAGTTACAGGCTGTCAATGGTCTGCTCTGTAGCAGTCTCAGAGCCTCCCCGACCCACTACCTGGAGATAGCCAG
ATAGCCAGATGCCCTGCTCCTGGCCACCTTTAAAGCCCCTGCATATGACACAGGTTAACTAAAGTCAAGATTGGGGCTGCTGCATTCCAG
GTTCCCTAGACTCACAAGCTGGTCCTTGGCCAGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCA
CCTGAAGTCAGAAGTTTGAGACCAGCCTGGCCAACATAATTAAAATGTCTCTACTAAAAATACAAAAAATTAGCTGGGTGTGGTGACGCT
TGCCTGTATCCCAGCTACTCAGGAAGCTGAGACACGAGAATCACTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCTCAGATAGTGCCACT
GCACTCCAGCCTGGGTGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAGAAAGCAGATCCTCATGGCTATAGAGTTGGCATTTTAGCC
CCAGCTTCTGTAGCTCTGAAAGCCTAAAGAAGGTATTCTCTCCATCTGTTAAACACAGTATAGTGGCTCTCAGCCCTTGGGGCATGTTAT
CATGGGAGGGAAGTCAAATAAGAGGAGAGAAAAGAACTCAAGGGGGAAACTGCATTTTTAGGCTTTGCTCTCTTACCTTGCCCTTTCTAC
TCAGAACCAATAACTTCTGCATCAAAACATGTTACAGCCTGCATCAAGGGCTTTACCCCAACCTGCAGCCCAGCCTTCCCTGGGTGAGCT
TGCTATGCGCAGCCACATTTACCATGTGGGGCTCCCTATTCTGATGGCCTGTTCGGTGCCGGGTTTACTCACTGCCCTGTTCTGATGTCA
GTGCCTGTACATACCTCCAAAGGCAGGACTTGCCTGATAAATATTTTTCCTCCTCTGAACTGGATTTTATAGGCATTAAAGACAAGTCGG
GTGGCTAGAGGGCTCCTTGAGACATACCTAGCAGGGAACTGCAGGTGGATTCTGTTGAGAGGCAAAGCACCTGAGTGGTTGGGACACAGG
CAGCTGGCATGGGAGGGACTTTTTTTGAGACAGGGTCTCACTGTGTCGCCCAGGGCAAGGATGCCCAAAGACACCAGGTTGGAGAGGCAC
CTGCCAACTACTTGCTTTCCCTGGAGCCTGCATGTGCCTGTGGGGTGGGGAGGCGTAGGGGTCTACGGCTGCCTGAGATGGGTGTGCACA
GTGTGTGAAGTACCTACCTCCTTGCCTTGCTGGACTGTCAGCCAGTCGCAGGGCCGGCCACAAGACCCATGTCTCCATCTGGTCATACTC
CATAGCTACCAAGTTAACCTGCTCTAAACTTTGGAGAACTGGATCTGTCCAATAAACGCTTATTTGGCCAAGCCTGATGGCTCGTGCCTG
TACTCCCAGCACTTTGGGAGGCTGAGGTGGGAGGGTTGCTTGAGCCCAGGGGTTTGAGACCAGCTTGGGCAACAACAACAAAAATGCCAG
GTGTGGTGGGGTGCACCTGTAGTCCCAGCTACTAGGGAGGCTGAGCCAGGAGGATCACTTGAGCCCGGGAGGTTGAGGCTGCAGTGGGGG
GTCATAATCATGCCACTGTACTCCAGCCTGGGTGACAGAGTGAGACCCTGTCTCCGAAAAAAAAAAAAAAAAAAAGAACGGAAAAAGAAA
TGCTTACATTGTCAGGGATCCTGTAGACAATCATTAACTCTATGAGATGCTTGGTTCTATTTTTTTGGGAGACTTTGTCCAAGTGTTTTG
GCTTAAGAAATCCATAGGCCTCTCTTGGTGACACATCTCTAGTACTTTTTGTCATAAACAAACAGGCCATCTGCCGCCAAATACATCCAC
TCCCCATGCCACTGACATCCTATGGGTCAGCCAGGCTTGCTTTGACTGAGGCCGAGGCATCTGGAACTTTCTCTGCCTGCAGGGGCTAGC
AGCAGAGGCTTCACCGCATCACCACCCCTTCCTCCACTCCTGACATTCTTTCCCTTCAGGGATCCAAAATGGTTGGCCGAGCTCCCAGTG
GGAAAACGTGTGCTAGAGTTGGGGAGTGAGATGAGTGGTGCTGTCCATGGAATCAGGCCACAGCAGGAACTGCCCCACTGGCCATTTGAG
ACACACACAGGTGGTAAATGCTCTGCTGGTGGGCTGTGCTTCCCTCATTCAGAGAGCTCTGTTACAGCCCACTGTGTCCTTTAGAAGCTT
GAAAGGAACCCAACTCTTTGCTGCACTGTCCTTTTTCTTCCTCAAATTCAGACCCTCCTTCCACCGGCACCCCCCTACTCCACCCTCAGC
TCTTCCTTGCCTGGTTTATCAAGCAGAGCTGAGGCCCCACGTTTCCAACTCTGATTGTCACTTGCATCTTCACAAAGGATAAACCACGGA
GCAACTGGAAAACCATCAGCCAAGCGTTCGGATGAGTCTGGTTATTGGTCCACCCCCGACCAGATTCCCTTACACTTAACTCACTTCTTT
CTTTGGCAATGACCCTCATGACATGTATAAATGGGTATGACTAAGAAGAGGCTGTGATCTAACATTTATTTGCTGCCATTTTTTACTCTG
GGGAGAAGCAGCCCCAACTCATCACTGGGAAAGAACTCCCCCTGCAAACCAGCTAAATTTGATAATTTAAACCCCCTGCCCCTAAAACTT
CTCACAGAGCTGGGGAGTTGGTGGCAACTTTCCAAGTCAAGGTCTTGCTTAGAAAGTCCTTCACTACATGGCCAGGTGCAGTGGCTCACG
CCTGTAGTCCCAGGTACTTGGGAGCCTGAGGCAGGAGGATTGCTTGAGCTCAGGAGTTCAAGGCTGCAGAGAGCTATGATCATCCCACTG
CATTTGTTTAAAAATAAATTTTTAAAATTTGTGTGTTTTATCAGGGGTCTCCTGTACAGTGTATCTGTGTATGTTTGTGTGTGTGTTTGT
ATACAGCCTTGTTTAATGTTTTGAGCAATAAGATATGCACACACAGGTATTTTGTTGCTAAAGAGATTGGACAAGGTTGTAGCTGTGCTC
AGGCTTCAGCTTGGTTTGTTAAATTGAGAGATAAACAATGACAAGAGCTGCCAGCCAACCACACTATTCAAAAAGCAAAGTGTTCACCAC
TAAAGCTAACCATTCATCTGGTTGCAGGCAAGGCTAAGGCTCTCTCTCCTCTAGTTCCTGGAACAGACTCACAGATTGGCATGAAGCACT
GATCAGGGGCTGCACTCAGACTCCCTGGCCAAGCAAACCTACACCAGAAGAGTCAGTGTCACAGATATGATGCGGCCAATCTCTGTCTCC
AAAAACCTACCTGAACTTAATGGTAGAATTCAAAGATCTGGGGACTGAGGGCACCCAGCCTTCTAAAACACAATGTATTCATGTGTTTAG
TGTAAACTCTCTGCATGGATTCTCAGTGTTAATAATAAAAGGAAGCATTCTTTTACAACTCCTGCTGTGTGCAAAAGAAAGTGCAAAGGA
TTTGGAGTGGCATTCCGAAGATCACCACACATACCTTGGTTCTGATGGCTGCTGAACTCCGACTTCTTCGCTGAGACATGACTGTGGGAA
CAGCCTCCAGCTATCTGCTCATCAGAGGTGCTTTCCTCAACCTCCTGCACCACCTCCAAGAGAAACAGCCTAAAAAGAAACCCCAGCTGT
TTACTTATATTGGTCTGTAAATCCCTGGAAGTAAACCCCATGCATTTTTATCTACTGTCTGAGGACATACAATAAATCTGAGAAAGTCTA

>10098_10098_3_BPTF-PLXDC1_BPTF_chr17_65962772_ENST00000335221_PLXDC1_chr17_37243955_ENST00000315392_length(amino acids)=3059AA_BP=0
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGRRKPRVHRPRSPILEEKDIPPLEFPKSSEDLMVPNEHIMNVIAIYEVLRNFGTVLRLSPFRFEDF
CAALVSQEQCTLMAEMHVVLLKAVLREEDTSNTTFGPADLKDSVNSTLYFIDGMTWPEVLRVYCESDKEYHHVLPYQEAEDYPYGPVENK
IKVLQFLVDQFLTTNIAREELMSEGVIQYDDHCRVCHKLGDLLCCETCSAVYHLECVKPPLEEVPEDEWQCEVCVAHKVPGVTDCVAEIQ
KNKPYIRHEPIGYDRSRRKYWFLNRRLIIEEDTENENEKKIWYYSTKVQLAELIDCLDKDYWEAELCKILEEMREEIHRHMDITEDLTNK
ARGSNKSFLAAANEEILESIRAKKGDIDNVKSPEETEKDKNETENDSKDAEKNREEFEDQSLEKDSDDKTPDDDPEQGKSEEPTEVGDKG
NSVSANLGDNTTNATSEETSPSEGRSPVGCLSETPDSSNMAEKKVASELPQDVPEEPNKTCESSNTSATTTSIQPNLENSNSSSELNSSQ
SESAKAADDPENGERESHTPVSIQEEIVGDFKSEKSNGELSESPGAGKGASGSTRIITRLRNPDSKLSQLKSQQVAAAAHEANKLFKEGK
EVLVVNSQGEISRLSTKKEVIMKGNINNYFKLGQEGKYRVYHNQYSTNSFALNKHQHREDHDKRRHLAHKFCLTPAGEFKWNGSVHGSKV
LTISTLRLTITQLENNIPSSFLHPNWASHRANWIKAVQMCSKPREFALALAILECAVKPVVMLPIWRESLGHTRLHRMTSIEREEKEKVK
KKEKKQEEEETMQQATWVKYTFPVKHQVWKQKGEEYRVTGYGGWSWISKTHVYRFVPKLPGNTNVNYRKSLEGTKNNMDENMDESDKRKC
SRSPKKIKIEPDSEKDEVKGSDAAKGADQNEMDISKITEKKDQDVKELLDSDSDKPCKEEPMEVDDDMKTESHVNCQESSQVDVVNVSEG
FHLRTSYKKKTKSSKLDGLLERRIKQFTLEEKQRLEKIKLEGGIKGIGKTSTNSSKNLSESPVITKAKEGCQSDSMRQEQSPNANNDQPE
DLIQGCSESDSSVLRMSDPSHTTNKLYPKDRVLDDVSIRSPETKCPKQNSIENDIEEKVSDLASRGQEPSKSKTKGNDFFIDDSKLASAD
DIGTLICKNKKPLIQEESDTIVSSSKSALHSSVPKSTNDRDATPLSRAMDFEGKLGCDSESNSTLENSSDTVSIQDSSEEDMIVQNSNES
ISEQFRTREQDVEVLEPLKCELVSGESTGNCEDRLPVKGTEANGKKPSQQKKLEERPVNKCSDQIKLKNTTDKKNNENRESEKKGQRTST
FQINGKDNKPKIYLKGECLKEISESRVVSGNVEPKVNNINKIIPENDIKSLTVKESAIRPFINGDVIMEDFNERNSSETKSHLLSSSDAE
GNYRDSLETLPSTKESDSTQTTTPSASCPESNSVNQVEDMEIETSEVKKVTSSPITSEEESNLSNDFIDENGLPINKNENVNGESKRKTV
ITEVTTMTSTVATESKTVIKVEKGDKQTVVSSTENCAKSTVTTTTTTVTKLSTPSTGGSVDIISVKEQSKTVVTTTVTDSLTTTGGTLVT
SMTVSKEYSTRDKVKLMKFSRPKKTRSGTALPSYRKFVTKSSKKSIFVLPNDDLKKLARKGGIREVPYFNYNAKPALDIWPYPSPRPTFG
ITWRYRLQTVKSLAGVSLMLRLLWASLRWDDMAAKAPPGGGTTRTETSETEITTTEIIKRRDVGPYGIRSEYCIRKIICPIGVPETPKET
PTPQRKGLRSSALRPKRPETPKQTGPVIIETWVAEEELELWEIRAFAERVEKEKAQAVEQQAKKRLEQQKPTVIATSTTSPTSSTTSTIS
PAQKVMVAPISGSVTTGTKMVLTTKVGSPATVTFQQNKNFHQTFATWVKQGQSNSGVVQVQQKVLGIIPSSTGTSQQTFTSFQPRTATVT
IRPNTSGSGGTTSNSQVITGPQIRPGMTVIRTPLQQSTLGKAIIRTPVMVQPGAPQQVMTQIIRGQPVSTAVSAPNTVSSTPGQKSLTSA
TSTSNIQSSASQPPRPQQGQVKLTMAQLTQLTQGHGGNQGLTVVIQGQGQTTGQLQLIPQGVTVLPGPGQQLMQAAMPNGTVQRFLFTPL
ATTATTASTTTTTVSTTAAGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTT
VSSHVPSEAQPTHAQSSKPQVAAQSQPQSNVQGQSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQ
PQVVMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEEKQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAEIL
KKRALLDKDLQIEVQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKRKREEEK
DSSSKSKKKKMISTTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTPLTEKDY
EGLKRVLRSLQAHKMAWPFLEPVDPNDAPDYYGVIKEPMESRRRSIFEYHRIELDPSKVTSMSAVEFTPLPTCLQHRSCDACMSSDLTFN
CSWCHVLQRCSSGFDRYRQEWMDYGCAQEAEGRMCEDFQDEDHDSASPDTSFSPYDGDLTTTSSSLFIDSLTTEDDTKLNPYAGGDGLQN

--------------------------------------------------------------
>10098_10098_4_BPTF-PLXDC1_BPTF_chr17_65962772_ENST00000424123_PLXDC1_chr17_37243955_ENST00000315392_length(transcript)=13300nt_BP=8071nt
ATGGTCTCCGAGGAGGAGGAGGAGGAGGACGGCGACGCCGAGGAGACCCAGGATTCTGAGGACGACGAGGAGGATGAGATGGAAGAGGAC
GACGATGACTCCGATTATCCGGAGGAGATGGAAGACGACGACGACGACGCCAGTTACTGCACGGAAAGCAGCTTCAGGAGCCATAGTACC
TACAGCAGCACTCCAGGTAGGCGAAAACCAAGAGTACATCGGCCTCGTTCTCCTATATTGGAAGAAAAAGACATCCCGCCCCTTGAATTT
CCCAAGTCCTCTGAGGATTTAATGGTGCCTAATGAGCATATAATGAATGTCATTGCCATTTACGAGGTACTGCGGAACTTTGGCACTGTT
TTGAGATTATCTCCTTTTCGCTTTGAGGACTTTTGTGCAGCTCTGGTGAGCCAAGAGCAGTGCACACTCATGGCAGAGATGCATGTTGTG
CTTTTGAAAGCAGTTCTGCGTGAAGAAGACACTTCCAATACTACCTTTGGACCTGCTGATCTGAAAGATAGCGTTAATTCCACACTGTAT
TTCATAGATGGGATGACGTGGCCAGAGGTGCTGCGGGTGTACTGTGAGAGTGATAAGGAGTACCATCACGTTCTTCCTTACCAAGAGGCA
GAGGACTACCCATATGGACCAGTAGAGAACAAGATCAAAGTTCTACAGTTTCTAGTCGATCAGTTTCTTACAACAAATATTGCTCGAGAG
GAATTGATGTCTGAAGGGGTGATACAGTATGATGACCATTGTAGGGTTTGTCACAAACTTGGGGATTTGCTTTGCTGTGAGACATGTTCA
GCAGTATACCATTTGGAATGTGTGAAGCCACCTCTTGAGGAGGTGCCAGAGGACGAGTGGCAGTGTGAAGTCTGTGTAGCACACAAGGTG
CCTGGTGTGACTGACTGTGTTGCTGAAATCCAAAAAAATAAACCATATATTCGACATGAACCTATTGGATATGATAGAAGTCGGAGGAAA
TACTGGTTCTTGAACCGAAGACTCATAATAGAAGAAGATACAGAAAATGAAAATGAAAAGAAAATTTGGTATTACAGCACAAAGGTCCAA
CTTGCAGAATTAATTGACTGTCTAGACAAAGATTATTGGGAAGCAGAACTCTGCAAAATTCTAGAAGAAATGCGTGAAGAAATCCACCGA
CACATGGACATAACTGAAGACCTGACCAATAAGGCTCGGGGCAGTAACAAATCCTTTCTGGCGGCAGCTAATGAAGAAATTTTGGAATCC
ATAAGAGCCAAAAAGGGAGACATTGATAATGTTAAAAGCCCAGAAGAAACAGAAAAAGACAAGAATGAGACTGAGAATGACTCTAAAGAT
GCTGAGAAAAACAGAGAAGAATTTGAAGACCAGTCCCTTGAAAAAGACAGTGACGACAAAACACCAGATGATGACCCTGAGCAAGGAAAA
TCTGAGGAGCCAACAGAAGTTGGGGATAAAGGTAACTCTGTGTCAGCAAATCTTGGCGACAACACAACAAATGCAACTTCAGAAGAGACT
AGTCCCTCTGAAGGGAGGAGCCCTGTGGGGTGTCTCTCAGAAACCCCCGATAGCAGCAACATGGCAGAGAAGAAGGTGGCATCTGAGCTC
CCCCAGGATGTGCCAGAAGAACCTAACAAGACATGTGAGAGCAGTAACACTAGTGCTACCACTACCTCCATCCAGCCTAATCTGGAAAAC
AGTAACAGCAGCAGTGAACTAAATTCTTCCCAGAGTGAATCTGCTAAGGCAGCTGATGATCCTGAAAATGGAGAAAGAGAATCTCATACA
CCTGTCTCTATTCAGGAAGAGATAGTAGGTGATTTCAAATCGGAGAAGTCCAACGGGGAGCTAAGTGAATCTCCTGGAGCTGGAAAAGGA
GCATCTGGCTCAACTCGAATCATCACCAGATTGCGGAATCCAGATAGCAAACTTAGTCAGCTGAAGAGCCAGCAGGTGGCAGCCGCTGCA
CATGAAGCAAATAAATTATTTAAGGAGGGCAAAGAGGTACTGGTAGTTAACTCTCAAGGAGAAATTTCACGGTTGAGCACCAAAAAGGAA
GTGATCATGAAAGGAAATATCAACAATTATTTTAAATTGGGTCAAGAAGGGAAGTATCGCGTCTACCACAATCAATACTCCACCAATTCA
TTTGCTTTGAATAAGCACCAGCACAGAGAAGACCATGATAAGAGAAGGCATCTTGCACATAAGTTCTGTCTGACTCCAGCAGGAGAGTTC
AAATGGAACGGTTCTGTCCATGGGTCCAAAGTTCTTACCATATCTACTCTGAGACTGACTATCACCCAATTAGAAAACAACATCCCTTCA
TCCTTTCTTCATCCCAACTGGGCATCACATAGGGCAAATTGGATCAAGGCAGTTCAGATGTGTAGCAAACCCAGAGAATTTGCATTGGCT
TTAGCCATTTTGGAGTGTGCAGTTAAACCAGTTGTGATGCTACCAATATGGCGAGAATCTTTAGGACATACCAGGTTACACCGGATGACA
TCAATTGAAAGAGAAGAAAAGGAGAAAGTCAAAAAAAAAGAGAAGAAACAGGAAGAAGAAGAAACGATGCAGCAAGCGACATGGGTAAAA
TACACATTTCCAGTTAAGCATCAGGTTTGGAAACAAAAAGGTGAAGAGTACAGAGTGACAGGATATGGTGGTTGGAGCTGGATTAGTAAA
ACTCATGTTTATAGGTTTGTTCCTAAATTGCCAGGCAATACTAATGTGAATTACAGAAAGTCGTTAGAAGGAACCAAAAATAATATGGAT
GAAAATATGGATGAGTCAGATAAAAGAAAATGTTCACGAAGTCCAAAAAAAATAAAAATAGAGCCTGATTCTGAAAAAGATGAGGTAAAA
GGTTCAGATGCTGCAAAAGGAGCAGACCAAAATGAAATGGATATCTCAAAGATTACTGAGAAGAAGGACCAAGATGTGAAGGAGCTCTTA
GATTCTGACAGTGATAAACCCTGCAAGGAAGAACCAATGGAAGTAGACGATGACATGAAAACAGAGTCACATGTAAATTGTCAGGAGAGT
TCTCAAGTAGATGTGGTCAATGTTAGTGAGGGTTTTCATCTAAGGACTAGTTACAAAAAGAAAACAAAATCATCCAAACTAGATGGACTT
CTTGAAAGGAGAATTAAACAGTTTACACTGGAAGAAAAACAGCGACTCGAAAAAATCAAGTTGGAGGGTGGAATTAAGGGTATAGGAAAG
ACTTCTACAAATTCTTCAAAAAATCTCTCTGAATCACCAGTAATAACGAAAGCAAAAGAAGGGTGTCAGAGTGACTCGATGAGACAAGAA
CAGAGCCCAAATGCAAATAATGATCAACCTGAGGACTTGATTCAGGGATGTTCAGAAAGTGATTCCTCAGTTCTTAGAATGAGTGATCCT
AGTCATACCACAAACAAACTTTATCCAAAAGATCGAGTGTTAGATGATGTCTCCATTCGGAGCCCAGAAACAAAATGTCCGAAACAAAAT
TCCATTGAAAATGACATAGAAGAAAAAGTCTCTGACCTTGCCAGTAGAGGCCAGGAACCCAGTAAGAGTAAAACAAAAGGAAATGATTTT
TTCATCGATGACTCTAAACTAGCCAGTGCAGATGATATTGGTACTTTGATCTGTAAGAACAAAAAACCGCTCATACAGGAGGAAAGTGAC
ACCATTGTTTCTTCTTCCAAGAGTGCTTTACATTCATCAGTGCCTAAAAGTACCAATGACAGAGATGCCACACCTCTGTCAAGAGCAATG
GACTTTGAAGGAAAACTGGGATGTGACTCTGAATCTAATAGCACTTTGGAAAATAGTTCTGATACCGTGTCTATTCAGGATAGCAGTGAA
GAAGATATGATTGTTCAGAATAGCAATGAAAGCATTTCTGAACAGTTCAGAACTCGAGAACAAGATGTTGAAGTCTTGGAGCCGTTAAAG
TGTGAGTTGGTTTCTGGTGAGTCCACTGGAAACTGTGAGGACAGGCTGCCGGTCAAGGGGACTGAAGCAAATGGTAAAAAACCAAGTCAG
CAGAAGAAATTAGAGGAGAGACCAGTTAATAAATGTAGTGATCAAATAAAGCTAAAAAATACCACTGACAAAAAGAATAATGAAAATCGA
GAGTCTGAAAAGAAAGGACAGAGAACAAGTACATTTCAAATAAATGGAAAAGATAATAAACCCAAAATATATTTGAAAGGTGAATGCTTG
AAAGAAATTTCTGAGAGTAGAGTAGTAAGTGGTAATGTTGAACCAAAGGTTAATAATATAAATAAAATAATCCCTGAGAATGATATTAAA
TCATTGACTGTTAAAGAATCTGCTATAAGGCCATTCATTAATGGTGATGTCATCATGGAAGATTTTAATGAAAGAAACAGCTCCGAAACA
AAATCGCATTTGCTGAGTTCTTCAGATGCTGAAGGTAACTACCGAGATAGCCTTGAGACCCTGCCATCAACCAAAGAGTCTGACAGTACA
CAGACGACCACACCCTCAGCATCTTGTCCAGAAAGCAATTCAGTTAATCAGGTAGAAGATATGGAAATAGAAACCTCAGAAGTTAAGAAA
GTTACTTCATCACCTATTACTTCTGAAGAGGAATCTAATCTCAGTAATGACTTTATTGATGAAAATGGTCTGCCCATCAACAAAAATGAA
AATGTCAATGGAGAATCTAAAAGAAAAACCGTCATCACAGAAGTCACCACGATGACCTCCACAGTGGCCACAGAATCAAAAACTGTGATC
AAGGTAGAAAAAGGCGATAAGCAAACTGTGGTTTCTTCCACAGAAAATTGTGCAAAATCCACTGTCACAACCACCACTACAACAGTGACC
AAGCTTTCCACACCCTCCACAGGCGGCAGTGTGGACATCATCTCTGTAAAGGAGCAGAGCAAAACCGTGGTCACCACGACAGTGACAGAC
TCCCTGACCACCACGGGAGGCACACTGGTTACATCTATGACTGTGAGCAAAGAGTATTCCACACGAGACAAAGTGAAACTGATGAAATTT
TCAAGACCAAAGAAGACTCGTTCAGGTACAGCTCTGCCATCCTATAGAAAATTTGTTACCAAGAGCAGCAAGAAGAGCATTTTTGTTTTG
CCTAATGATGACTTAAAAAAGTTGGCCCGAAAAGGAGGAATCCGAGAGGTCCCTTATTTTAATTACAATGCAAAACCTGCTTTGGATATA
TGGCCATATCCTTCTCCTAGACCGACCTTTGGCATCACTTGGAGGTATAGACTTCAGACAGTAAAGTCCTTAGCTGGAGTGAGCCTGATG
TTACGGTTACTGTGGGCAAGTTTGAGATGGGATGATATGGCGGCCAAGGCTCCTCCAGGAGGAGGGACTACACGGACAGAAACATCCGAA
ACTGAAATCACAACAACAGAAATAATTAAGAGGAGAGATGTTGGTCCTTATGGCATTCGATCTGAATATTGTATCAGGAAAATCATTTGT
CCCATTGGAGTTCCAGAAACACCAAAAGAAACGCCTACACCTCAGAGGAAAGGCCTTCGATCAAGTGCACTGCGGCCAAAGAGACCAGAA
ACGCCCAAGCAAACTGGCCCTGTTATTATTGAAACCTGGGTAGCAGAAGAAGAACTGGAATTGTGGGAGATCAGGGCATTTGCTGAGAGA
GTGGAGAAAGAAAAGGCACAAGCAGTTGAGCAACAGGCTAAGAAACGACTGGAGCAGCAGAAGCCGACAGTGATTGCAACTTCCACTACT
TCCCCAACAAGCAGTACAACCAGCACCATCTCTCCAGCACAGAAGGTTATGGTGGCCCCCATAAGTGGCTCAGTTACAACTGGAACCAAA
ATGGTACTAACTACTAAAGTTGGATCTCCAGCTACAGTAACATTCCAACAAAACAAGAACTTTCATCAAACCTTTGCTACATGGGTTAAG
CAAGGCCAGTCAAATTCAGGCGTTGTTCAAGTACAGCAGAAAGTCCTGGGTATCATTCCATCAAGTACAGGTACCAGTCAGCAAACCTTT
ACTTCATTCCAGCCCAGGACAGCAACAGTCACAATTAGGCCCAATACCTCAGGCTCTGGAGGAACCACAAGCAATTCACAAGTAATCACA
GGGCCTCAGATTCGCCCTGGTATGACCGTGATTAGAACACCACTCCAACAGTCAACACTAGGAAAGGCAATTATTCGAACACCTGTGATG
GTACAGCCAGGTGCTCCTCAGCAAGTGATGACTCAAATCATCAGGGGGCAGCCTGTCTCCACTGCAGTCTCCGCCCCTAACACGGTTTCC
TCAACACCTGGGCAGAAAAGCTTAACTTCAGCAACGTCCACTTCAAATATACAGTCTTCAGCCTCACAACCCCCTCGCCCCCAACAAGGA
CAAGTGAAGCTCACCATGGCTCAACTTACTCAGTTAACACAGGGCCACGGTGGCAATCAAGGTTTGACAGTAGTAATTCAAGGACAAGGT
CAAACTACTGGACAGTTGCAGTTGATACCTCAAGGGGTGACTGTACTCCCAGGCCCAGGCCAGCAGCTAATGCAAGCTGCAATGCCAAAT
GGTACTGTTCAGCGATTCCTCTTTACCCCATTGGCAACAACAGCCACCACAGCCAGCACCACCACCACCACTGTTTCCACGACAGCAGCA
GGTACAGGTGAACAAAGGCAGAGTAAACTGTCACCCCAGATGCAGGTACATCAAGACAAAACCCTGCCACCAGCTCAGTCATCAAGTGTG
GGTCCAGCAGAAGCCCAGCCACAGACTGCTCAGCCTTCAGCTCAGCCCCAGCCCCAAACCCAGCCCCAGTCCCCAGCTCAGCCTGAAGTT
CAGACTCAGCCTGAAGTTCAGACCCAAACAACTGTTTCATCCCATGTCCCTTCTGAAGCACAACCCACCCACGCACAGTCATCCAAGCCC
CAAGTTGCAGCACAGTCTCAGCCTCAAAGTAATGTCCAAGGACAGTCTCCTGTTCGTGTCCAAAGTCCATCACAGACTCGAATACGTCCA
TCAACTCCATCCCAACTGTCTCCTGGACAACAATCCCAGGTTCAGACTACAACCTCACAACCGATTCCAATTCAACCACATACATCTCTT
CAGATACCTTCCCAAGGCCAGCCACAGTCACAACCCCAGGTGGTGATGAAGCATAATGCTGTAATAGAACATTTAAAACAGAAAAAGAGC
ATGACTCCAGCTGAAAGAGAAGAGAATCAAAGAATGATTGTCTGTAACCAGGTGATGAAGTATATTTTGGATAAGATAGATAAAGAAGAA
AAACAGGCAGCAAAAAAACGGAAGCGTGAAGAGAGTGTGGAGCAGAAACGTAGCAAGCAGAATGCCACTAAGCTGTCAGCTCTGCTCTTC
AAGCACAAAGAGCAGCTCAGAGCCGAGATCCTGAAGAAGAGAGCACTCCTGGACAAGGATCTGCAAATTGAAGTGCAGGAAGAGCTGAAG
AGAGACCTGAAAATTAAGAAAGAAAAAGACCTGATGCAGTTGGCTCAGGCCACAGCAGTAGCTGCACCCTGCCCCCCAGTGACACCAGCT
CCTCCAGCCCCTCCAGCCCCTCCACCTTCACCTCCCCCTCCACCTGCTGTGCAACACACAGGCCTTCTGTCCACGCCCACCTTACCTGCT
GCTTCCCAGAAGAGGAAGCGGGAAGAGGAAAAAGACTCCAGCTCAAAGTCCAAGAAAAAGAAAATGATCTCTACTACCTCAAAGGAAACT
AAGAAGGACACAAAGCTTTACTGTATCTGTAAAACGCCTTATGATGAATCTAAATTTTATATTGGCTGTGATCGGTGTCAGAATTGGTAC
CATGGGCGCTGCGTTGGCATCTTGCAAAGTGAGGCAGAGCTCATTGATGAGTATGTCTGTCCACAGTGCCAGTCAACAGAGGATGCCATG
ACAGTGCTCACGCCACTAACAGAGAAGGATTATGAGGGGTTGAAGAGGGTGCTCCGTTCCTTACAGGCCCATAAGATGGCCTGGCCTTTC
CTTGAACCAGTAGACCCTAATGATGCACCAGATTATTATGGTGTTATTAAGGAACCTATGGAATCTCGGCGAAGGAGCATCTTTGAATAT
CACCGCATAGAGCTGGACCCCAGCAAGGTCACCAGCATGTCGGCCGTGGAGTTCACCCCATTGCCGACCTGCCTGCAGCATAGGAGCTGT
GACGCCTGCATGTCCTCAGACCTGACCTTCAACTGCAGCTGGTGCCATGTCCTCCAGAGATGCTCCAGTGGCTTTGACCGCTATCGCCAG
GAGTGGATGGACTATGGCTGTGCACAGGAGGCAGAGGGCAGGATGTGCGAGGACTTCCAGGATGAGGACCACGACTCAGCCTCCCCTGAC
ACTTCCTTCAGCCCCTATGATGGAGACCTCACCACTACCTCCTCCTCCCTCTTCATCGACAGCCTCACCACAGAAGATGACACCAAGTTG
AATCCCTATGCAGGAGGAGACGGCCTTCAGAACAACCTGTCCCCCAAGACAAAGGGCACTCCTGTGCACCTGGGCACCATCGTGGGCATC
GTGCTGGCAGTCCTCCTCGTGGCGGCCATCATCCTGGCTGGAATTTACATCAATGGCCACCCCACATCCAATGCTGCGCTCTTCTTCATC
GAGCGTAGACCTCACCACTGGCCAGCCATGAAGTTTCGCAGCCACCCTGACCATTCCACCTATGCGGAGGTGGAGCCCTCGGGCCATGAG
AAGGAGGGCTTCATGGAGGCTGAGCAGTGCTGAGAACACCAAGTCTCCCCTTTGAAGACTTTGAGGCCACAGAAAAGACAGTTAAAGCAA
AGAAGAGAAGTGACTTTTCCTGGCCTCTCCCAGCATGCCCTGGGCTGAGATGAGATGGTGGTTTATGGCTCCAGAGCTGCTGCTCGCTTC
GTCAGCACACCCCGAATATTGAAGAGGGGGCCAAAAAACAACCACATGGATTTTTTATAGGAACAACAACCTAATCTCATCCTGTTTTGA
TGCAAGGGTTCTCTTCTGTGTCTTGTAACCATGAAACAGCAGAAGAACTAACATAACTAACTCCATTTTTGTTTAAGGGGCCTTTACCTA
TTCCTGCACCTAGGCTAGGATAACTTTAGAGCACTGACATAAAACGCAAAAACAGGAATCATGCCGTTTGCAAAACTAACTCTGGGATTA
AAGGGGAAGCATGTAAACAGCTAACTGTTTTTGTTAAAGATTTATAGGAATGAGGAGGTTTGGCTATTGTCACATGACAGACTGTTAGCC
AAGGACAAAGAAGTTCTGCAAACCTCCCCTGGACCCTTGCTGGTGTCCAGATGTCTGCGGTTGTCAGCCCCTTCCTTTCCCCCGACCTAA
ACATAAAAGACAAGGCAAAGCCCGCATAATTTTAAGACGGTTCTTTAGGACATTAGTCCACCATCTTCTTGGTTTGCTGGCTCTCCGAAA
TAAAGTCCCTTTCCTTGCTCCAACTCCTTGTCTCTCAACGTATTGGCTATGACGCAGCAAGCAGAATGAATTTGGACTCAGTTACAGGCT
GTCAATGGTCTGCTCTGTAGCAGTCTCAGAGCCTCCCCGACCCACTACCTGGAGATAGCCAGATAGCCAGATGCCCTGCTCCTGGCCACC
TTTAAAGCCCCTGCATATGACACAGGTTAACTAAAGTCAAGATTGGGGCTGCTGCATTCCAGGTTCCCTAGACTCACAAGCTGGTCCTTG
GCCAGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACCTGAAGTCAGAAGTTTGAGACCAGCCT
GGCCAACATAATTAAAATGTCTCTACTAAAAATACAAAAAATTAGCTGGGTGTGGTGACGCTTGCCTGTATCCCAGCTACTCAGGAAGCT
GAGACACGAGAATCACTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCTCAGATAGTGCCACTGCACTCCAGCCTGGGTGACAGAGCGAGA
CTCCGTCTCAAAAAAAAAAAAAGAAAGCAGATCCTCATGGCTATAGAGTTGGCATTTTAGCCCCAGCTTCTGTAGCTCTGAAAGCCTAAA
GAAGGTATTCTCTCCATCTGTTAAACACAGTATAGTGGCTCTCAGCCCTTGGGGCATGTTATCATGGGAGGGAAGTCAAATAAGAGGAGA
GAAAAGAACTCAAGGGGGAAACTGCATTTTTAGGCTTTGCTCTCTTACCTTGCCCTTTCTACTCAGAACCAATAACTTCTGCATCAAAAC
ATGTTACAGCCTGCATCAAGGGCTTTACCCCAACCTGCAGCCCAGCCTTCCCTGGGTGAGCTTGCTATGCGCAGCCACATTTACCATGTG
GGGCTCCCTATTCTGATGGCCTGTTCGGTGCCGGGTTTACTCACTGCCCTGTTCTGATGTCAGTGCCTGTACATACCTCCAAAGGCAGGA
CTTGCCTGATAAATATTTTTCCTCCTCTGAACTGGATTTTATAGGCATTAAAGACAAGTCGGGTGGCTAGAGGGCTCCTTGAGACATACC
TAGCAGGGAACTGCAGGTGGATTCTGTTGAGAGGCAAAGCACCTGAGTGGTTGGGACACAGGCAGCTGGCATGGGAGGGACTTTTTTTGA
GACAGGGTCTCACTGTGTCGCCCAGGGCAAGGATGCCCAAAGACACCAGGTTGGAGAGGCACCTGCCAACTACTTGCTTTCCCTGGAGCC
TGCATGTGCCTGTGGGGTGGGGAGGCGTAGGGGTCTACGGCTGCCTGAGATGGGTGTGCACAGTGTGTGAAGTACCTACCTCCTTGCCTT
GCTGGACTGTCAGCCAGTCGCAGGGCCGGCCACAAGACCCATGTCTCCATCTGGTCATACTCCATAGCTACCAAGTTAACCTGCTCTAAA
CTTTGGAGAACTGGATCTGTCCAATAAACGCTTATTTGGCCAAGCCTGATGGCTCGTGCCTGTACTCCCAGCACTTTGGGAGGCTGAGGT
GGGAGGGTTGCTTGAGCCCAGGGGTTTGAGACCAGCTTGGGCAACAACAACAAAAATGCCAGGTGTGGTGGGGTGCACCTGTAGTCCCAG
CTACTAGGGAGGCTGAGCCAGGAGGATCACTTGAGCCCGGGAGGTTGAGGCTGCAGTGGGGGGTCATAATCATGCCACTGTACTCCAGCC
TGGGTGACAGAGTGAGACCCTGTCTCCGAAAAAAAAAAAAAAAAAAAGAACGGAAAAAGAAATGCTTACATTGTCAGGGATCCTGTAGAC
AATCATTAACTCTATGAGATGCTTGGTTCTATTTTTTTGGGAGACTTTGTCCAAGTGTTTTGGCTTAAGAAATCCATAGGCCTCTCTTGG
TGACACATCTCTAGTACTTTTTGTCATAAACAAACAGGCCATCTGCCGCCAAATACATCCACTCCCCATGCCACTGACATCCTATGGGTC
AGCCAGGCTTGCTTTGACTGAGGCCGAGGCATCTGGAACTTTCTCTGCCTGCAGGGGCTAGCAGCAGAGGCTTCACCGCATCACCACCCC
TTCCTCCACTCCTGACATTCTTTCCCTTCAGGGATCCAAAATGGTTGGCCGAGCTCCCAGTGGGAAAACGTGTGCTAGAGTTGGGGAGTG
AGATGAGTGGTGCTGTCCATGGAATCAGGCCACAGCAGGAACTGCCCCACTGGCCATTTGAGACACACACAGGTGGTAAATGCTCTGCTG
GTGGGCTGTGCTTCCCTCATTCAGAGAGCTCTGTTACAGCCCACTGTGTCCTTTAGAAGCTTGAAAGGAACCCAACTCTTTGCTGCACTG
TCCTTTTTCTTCCTCAAATTCAGACCCTCCTTCCACCGGCACCCCCCTACTCCACCCTCAGCTCTTCCTTGCCTGGTTTATCAAGCAGAG
CTGAGGCCCCACGTTTCCAACTCTGATTGTCACTTGCATCTTCACAAAGGATAAACCACGGAGCAACTGGAAAACCATCAGCCAAGCGTT
CGGATGAGTCTGGTTATTGGTCCACCCCCGACCAGATTCCCTTACACTTAACTCACTTCTTTCTTTGGCAATGACCCTCATGACATGTAT
AAATGGGTATGACTAAGAAGAGGCTGTGATCTAACATTTATTTGCTGCCATTTTTTACTCTGGGGAGAAGCAGCCCCAACTCATCACTGG
GAAAGAACTCCCCCTGCAAACCAGCTAAATTTGATAATTTAAACCCCCTGCCCCTAAAACTTCTCACAGAGCTGGGGAGTTGGTGGCAAC
TTTCCAAGTCAAGGTCTTGCTTAGAAAGTCCTTCACTACATGGCCAGGTGCAGTGGCTCACGCCTGTAGTCCCAGGTACTTGGGAGCCTG
AGGCAGGAGGATTGCTTGAGCTCAGGAGTTCAAGGCTGCAGAGAGCTATGATCATCCCACTGCATTTGTTTAAAAATAAATTTTTAAAAT
TTGTGTGTTTTATCAGGGGTCTCCTGTACAGTGTATCTGTGTATGTTTGTGTGTGTGTTTGTATACAGCCTTGTTTAATGTTTTGAGCAA
TAAGATATGCACACACAGGTATTTTGTTGCTAAAGAGATTGGACAAGGTTGTAGCTGTGCTCAGGCTTCAGCTTGGTTTGTTAAATTGAG
AGATAAACAATGACAAGAGCTGCCAGCCAACCACACTATTCAAAAAGCAAAGTGTTCACCACTAAAGCTAACCATTCATCTGGTTGCAGG
CAAGGCTAAGGCTCTCTCTCCTCTAGTTCCTGGAACAGACTCACAGATTGGCATGAAGCACTGATCAGGGGCTGCACTCAGACTCCCTGG
CCAAGCAAACCTACACCAGAAGAGTCAGTGTCACAGATATGATGCGGCCAATCTCTGTCTCCAAAAACCTACCTGAACTTAATGGTAGAA
TTCAAAGATCTGGGGACTGAGGGCACCCAGCCTTCTAAAACACAATGTATTCATGTGTTTAGTGTAAACTCTCTGCATGGATTCTCAGTG
TTAATAATAAAAGGAAGCATTCTTTTACAACTCCTGCTGTGTGCAAAAGAAAGTGCAAAGGATTTGGAGTGGCATTCCGAAGATCACCAC
ACATACCTTGGTTCTGATGGCTGCTGAACTCCGACTTCTTCGCTGAGACATGACTGTGGGAACAGCCTCCAGCTATCTGCTCATCAGAGG
TGCTTTCCTCAACCTCCTGCACCACCTCCAAGAGAAACAGCCTAAAAAGAAACCCCAGCTGTTTACTTATATTGGTCTGTAAATCCCTGG

>10098_10098_4_BPTF-PLXDC1_BPTF_chr17_65962772_ENST00000424123_PLXDC1_chr17_37243955_ENST00000315392_length(amino acids)=2920AA_BP=2519
MVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEMEDDDDDASYCTESSFRSHSTYSSTPGRRKPRVHRPRSPILEEKDIPPLEF
PKSSEDLMVPNEHIMNVIAIYEVLRNFGTVLRLSPFRFEDFCAALVSQEQCTLMAEMHVVLLKAVLREEDTSNTTFGPADLKDSVNSTLY
FIDGMTWPEVLRVYCESDKEYHHVLPYQEAEDYPYGPVENKIKVLQFLVDQFLTTNIAREELMSEGVIQYDDHCRVCHKLGDLLCCETCS
AVYHLECVKPPLEEVPEDEWQCEVCVAHKVPGVTDCVAEIQKNKPYIRHEPIGYDRSRRKYWFLNRRLIIEEDTENENEKKIWYYSTKVQ
LAELIDCLDKDYWEAELCKILEEMREEIHRHMDITEDLTNKARGSNKSFLAAANEEILESIRAKKGDIDNVKSPEETEKDKNETENDSKD
AEKNREEFEDQSLEKDSDDKTPDDDPEQGKSEEPTEVGDKGNSVSANLGDNTTNATSEETSPSEGRSPVGCLSETPDSSNMAEKKVASEL
PQDVPEEPNKTCESSNTSATTTSIQPNLENSNSSSELNSSQSESAKAADDPENGERESHTPVSIQEEIVGDFKSEKSNGELSESPGAGKG
ASGSTRIITRLRNPDSKLSQLKSQQVAAAAHEANKLFKEGKEVLVVNSQGEISRLSTKKEVIMKGNINNYFKLGQEGKYRVYHNQYSTNS
FALNKHQHREDHDKRRHLAHKFCLTPAGEFKWNGSVHGSKVLTISTLRLTITQLENNIPSSFLHPNWASHRANWIKAVQMCSKPREFALA
LAILECAVKPVVMLPIWRESLGHTRLHRMTSIEREEKEKVKKKEKKQEEEETMQQATWVKYTFPVKHQVWKQKGEEYRVTGYGGWSWISK
THVYRFVPKLPGNTNVNYRKSLEGTKNNMDENMDESDKRKCSRSPKKIKIEPDSEKDEVKGSDAAKGADQNEMDISKITEKKDQDVKELL
DSDSDKPCKEEPMEVDDDMKTESHVNCQESSQVDVVNVSEGFHLRTSYKKKTKSSKLDGLLERRIKQFTLEEKQRLEKIKLEGGIKGIGK
TSTNSSKNLSESPVITKAKEGCQSDSMRQEQSPNANNDQPEDLIQGCSESDSSVLRMSDPSHTTNKLYPKDRVLDDVSIRSPETKCPKQN
SIENDIEEKVSDLASRGQEPSKSKTKGNDFFIDDSKLASADDIGTLICKNKKPLIQEESDTIVSSSKSALHSSVPKSTNDRDATPLSRAM
DFEGKLGCDSESNSTLENSSDTVSIQDSSEEDMIVQNSNESISEQFRTREQDVEVLEPLKCELVSGESTGNCEDRLPVKGTEANGKKPSQ
QKKLEERPVNKCSDQIKLKNTTDKKNNENRESEKKGQRTSTFQINGKDNKPKIYLKGECLKEISESRVVSGNVEPKVNNINKIIPENDIK
SLTVKESAIRPFINGDVIMEDFNERNSSETKSHLLSSSDAEGNYRDSLETLPSTKESDSTQTTTPSASCPESNSVNQVEDMEIETSEVKK
VTSSPITSEEESNLSNDFIDENGLPINKNENVNGESKRKTVITEVTTMTSTVATESKTVIKVEKGDKQTVVSSTENCAKSTVTTTTTTVT
KLSTPSTGGSVDIISVKEQSKTVVTTTVTDSLTTTGGTLVTSMTVSKEYSTRDKVKLMKFSRPKKTRSGTALPSYRKFVTKSSKKSIFVL
PNDDLKKLARKGGIREVPYFNYNAKPALDIWPYPSPRPTFGITWRYRLQTVKSLAGVSLMLRLLWASLRWDDMAAKAPPGGGTTRTETSE
TEITTTEIIKRRDVGPYGIRSEYCIRKIICPIGVPETPKETPTPQRKGLRSSALRPKRPETPKQTGPVIIETWVAEEELELWEIRAFAER
VEKEKAQAVEQQAKKRLEQQKPTVIATSTTSPTSSTTSTISPAQKVMVAPISGSVTTGTKMVLTTKVGSPATVTFQQNKNFHQTFATWVK
QGQSNSGVVQVQQKVLGIIPSSTGTSQQTFTSFQPRTATVTIRPNTSGSGGTTSNSQVITGPQIRPGMTVIRTPLQQSTLGKAIIRTPVM
VQPGAPQQVMTQIIRGQPVSTAVSAPNTVSSTPGQKSLTSATSTSNIQSSASQPPRPQQGQVKLTMAQLTQLTQGHGGNQGLTVVIQGQG
QTTGQLQLIPQGVTVLPGPGQQLMQAAMPNGTVQRFLFTPLATTATTASTTTTTVSTTAAGTGEQRQSKLSPQMQVHQDKTLPPAQSSSV
GPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTTVSSHVPSEAQPTHAQSSKPQVAAQSQPQSNVQGQSPVRVQSPSQTRIRP
STPSQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQPQVVMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEE
KQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAEILKKRALLDKDLQIEVQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPA
PPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKRKREEEKDSSSKSKKKKMISTTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWY
HGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVLRSLQAHKMAWPFLEPVDPNDAPDYYGVIKEPMESRRRSIFEY
HRIELDPSKVTSMSAVEFTPLPTCLQHRSCDACMSSDLTFNCSWCHVLQRCSSGFDRYRQEWMDYGCAQEAEGRMCEDFQDEDHDSASPD
TSFSPYDGDLTTTSSSLFIDSLTTEDDTKLNPYAGGDGLQNNLSPKTKGTPVHLGTIVGIVLAVLLVAAIILAGIYINGHPTSNAALFFI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for BPTF-PLXDC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneBPTFchr17:65962772chr17:37243955ENST00000306378+2628640_7492846.33333333333352921.0KEAP1
HgeneBPTFchr17:65962772chr17:37243955ENST00000321892+2830640_7492972.33333333333353047.0KEAP1
HgeneBPTFchr17:65962772chr17:37243955ENST00000335221+2830640_7492829.33333333333352904.0KEAP1
HgeneBPTFchr17:65962772chr17:37243955ENST00000306378+2628839_9212846.33333333333352921.0MAZ
HgeneBPTFchr17:65962772chr17:37243955ENST00000321892+2830839_9212972.33333333333353047.0MAZ
HgeneBPTFchr17:65962772chr17:37243955ENST00000335221+2830839_9212829.33333333333352904.0MAZ


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for BPTF-PLXDC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for BPTF-PLXDC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBPTFC0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneBPTFC0005695Bladder Neoplasm1CTD_human
HgeneBPTFC3714756Intellectual Disability1GENOMICS_ENGLAND
HgeneBPTFC4540327NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND DISTAL LIMB ANOMALIES1GENOMICS_ENGLAND;UNIPROT
TgeneC2239176Liver carcinoma1CTD_human