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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FASN-NRXN3 (FusionGDB2 ID:HG2194TG9369)

Fusion Gene Summary for FASN-NRXN3

check button Fusion gene summary
Fusion gene informationFusion gene name: FASN-NRXN3
Fusion gene ID: hg2194tg9369
HgeneTgene
Gene symbol

FASN

NRXN3

Gene ID

2194

9369

Gene namefatty acid synthaseneurexin 3
SynonymsFAS|OA-519|SDR27X1C14orf60
Cytomap('FASN')('NRXN3')

17q25.3

14q24.3-q31.1

Type of geneprotein-codingprotein-coding
Descriptionfatty acid synthaseshort chain dehydrogenase/reductase family 27X, member 1neurexin 3neurexin IIIneurexin-3-alpha
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000306749, ENST00000579758, 
Fusion gene scores* DoF score11 X 12 X 6=79213 X 12 X 3=468
# samples 1116
** MAII scorelog2(11/792*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/468*10)=-1.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FASN [Title/Abstract] AND NRXN3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFASN(80036321)-NRXN3(79757005), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for FASN-NRXN3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FASN-NRXN3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for FASN-NRXN3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:80036321/:79757005)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FASN-NRXN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FASN-NRXN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FASN-NRXN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FASN-NRXN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFASNC0025202melanoma3CTD_human
HgeneFASNC2239176Liver carcinoma3CTD_human
HgeneFASNC0006142Malignant neoplasm of breast2CTD_human
HgeneFASNC0678222Breast Carcinoma2CTD_human
HgeneFASNC1257931Mammary Neoplasms, Human2CTD_human
HgeneFASNC1458155Mammary Neoplasms2CTD_human
HgeneFASNC4704874Mammary Carcinoma, Human2CTD_human
HgeneFASNC0006826Malignant Neoplasms1CTD_human
HgeneFASNC0007193Cardiomyopathy, Dilated1CTD_human
HgeneFASNC0007194Hypertrophic Cardiomyopathy1CTD_human
HgeneFASNC0018801Heart failure1CTD_human
HgeneFASNC0018802Congestive heart failure1CTD_human
HgeneFASNC0019193Hepatitis, Toxic1CTD_human
HgeneFASNC0020796Profound Mental Retardation1CTD_human
HgeneFASNC0022661Kidney Failure, Chronic1CTD_human
HgeneFASNC0023212Left-Sided Heart Failure1CTD_human
HgeneFASNC0023827liposarcoma1CTD_human
HgeneFASNC0025363Mental Retardation, Psychosocial1CTD_human
HgeneFASNC0027651Neoplasms1CTD_human
HgeneFASNC0028754Obesity1CTD_human
HgeneFASNC0086132Depressive Symptoms1PSYGENET
HgeneFASNC0086692Benign Neoplasm1CTD_human
HgeneFASNC0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneFASNC0205824Liposarcoma, Dedifferentiated1CTD_human
HgeneFASNC0205825Liposarcoma, Pleomorphic1CTD_human
HgeneFASNC0235527Heart Failure, Right-Sided1CTD_human
HgeneFASNC0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneFASNC0860207Drug-Induced Liver Disease1CTD_human
HgeneFASNC0917816Mental deficiency1CTD_human
HgeneFASNC0919267ovarian neoplasm1CTD_human
HgeneFASNC0948089Acute Coronary Syndrome1CTD_human
HgeneFASNC1140680Malignant neoplasm of ovary1CTD_human
HgeneFASNC1262760Hepatitis, Drug-Induced1CTD_human
HgeneFASNC1370889Liposarcoma, well differentiated1CTD_human
HgeneFASNC1449563Cardiomyopathy, Familial Idiopathic1CTD_human
HgeneFASNC1959583Myocardial Failure1CTD_human
HgeneFASNC1961112Heart Decompensation1CTD_human
HgeneFASNC3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneFASNC3714756Intellectual Disability1CTD_human
HgeneFASNC4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneFASNC4279912Chemically-Induced Liver Toxicity1CTD_human
HgeneFASNC4551472Hypertrophic obstructive cardiomyopathy1CTD_human
TgeneC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneC0004352Autistic Disorder1GENOMICS_ENGLAND
TgeneC0013146Drug abuse1CTD_human
TgeneC0013170Drug habituation1CTD_human
TgeneC0013222Drug Use Disorders1CTD_human
TgeneC0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneC0036341Schizophrenia1PSYGENET
TgeneC0038580Substance Dependence1CTD_human
TgeneC0038586Substance Use Disorders1CTD_human
TgeneC0236969Substance-Related Disorders1CTD_human
TgeneC0740858Substance abuse problem1CTD_human
TgeneC0853193Bipolar I disorder1PSYGENET
TgeneC1510472Drug Dependence1CTD_human
TgeneC1510586Autism Spectrum Disorders1GENOMICS_ENGLAND
TgeneC4316881Prescription Drug Abuse1CTD_human