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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:C6orf89-SOD2 (FusionGDB2 ID:HG221477TG6648) |
Fusion Gene Summary for C6orf89-SOD2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: C6orf89-SOD2 | Fusion gene ID: hg221477tg6648 | Hgene | Tgene | Gene symbol | C6orf89 | SOD2 | Gene ID | 221477 | 6648 |
Gene name | chromosome 6 open reading frame 89 | superoxide dismutase 2 | |
Synonyms | BRAP|PS1TP5TP1 | GClnc1|IPO-B|IPOB|MNSOD|MVCD6|Mn-SOD | |
Cytomap | ('C6orf89')('SOD2') 6p21.2 | 6q25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | bombesin receptor-activated protein C6orf89amfion | superoxide dismutase [Mn], mitochondrialMn superoxide dismutaseepididymis secretory sperm binding proteingastric cancer-associated lncRNA 1indophenoloxidase Bmanganese-containing superoxide dismutasemangano-superoxide dismutasesuperoxide dismutase | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000480824, ENST00000355190, ENST00000359359, ENST00000373685, ENST00000510325, | ||
Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 13 X 22 X 6=1716 |
# samples | 5 | 22 | |
** MAII score | log2(5/50*10)=0 | log2(22/1716*10)=-2.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: C6orf89 [Title/Abstract] AND SOD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | C6orf89(36894637)-SOD2(160100839), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | C6orf89 | GO:0042060 | wound healing | 21857995 |
Hgene | C6orf89 | GO:0045787 | positive regulation of cell cycle | 21857995 |
Hgene | C6orf89 | GO:0050673 | epithelial cell proliferation | 21857995 |
Hgene | C6orf89 | GO:1901727 | positive regulation of histone deacetylase activity | 23460338 |
Tgene | SOD2 | GO:0006801 | superoxide metabolic process | 12551919|14980699 |
Tgene | SOD2 | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation | 27021683 |
Tgene | SOD2 | GO:1905461 | positive regulation of vascular associated smooth muscle cell apoptotic process | 27021683 |
Tgene | SOD2 | GO:1905932 | positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching | 27021683 |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SARC | TCGA-HB-A2OT-01A | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
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Fusion Gene ORF analysis for C6orf89-SOD2 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000480824 | ENST00000538183 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
3UTR-intron | ENST00000480824 | ENST00000337404 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
3UTR-intron | ENST00000480824 | ENST00000367054 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
3UTR-intron | ENST00000480824 | ENST00000367055 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
3UTR-intron | ENST00000480824 | ENST00000444946 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
3UTR-intron | ENST00000480824 | ENST00000452684 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
3UTR-intron | ENST00000480824 | ENST00000535372 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
3UTR-intron | ENST00000480824 | ENST00000546087 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-3UTR | ENST00000355190 | ENST00000538183 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-3UTR | ENST00000359359 | ENST00000538183 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-3UTR | ENST00000373685 | ENST00000538183 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-3UTR | ENST00000510325 | ENST00000538183 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000355190 | ENST00000337404 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000355190 | ENST00000367054 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000355190 | ENST00000367055 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000355190 | ENST00000444946 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000355190 | ENST00000452684 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000355190 | ENST00000535372 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000355190 | ENST00000546087 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000359359 | ENST00000337404 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000359359 | ENST00000367054 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000359359 | ENST00000367055 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000359359 | ENST00000444946 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000359359 | ENST00000452684 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000359359 | ENST00000535372 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000359359 | ENST00000546087 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000373685 | ENST00000337404 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000373685 | ENST00000367054 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000373685 | ENST00000367055 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000373685 | ENST00000444946 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000373685 | ENST00000452684 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000373685 | ENST00000535372 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000373685 | ENST00000546087 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000510325 | ENST00000337404 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000510325 | ENST00000367054 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000510325 | ENST00000367055 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000510325 | ENST00000444946 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000510325 | ENST00000452684 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000510325 | ENST00000535372 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
intron-intron | ENST00000510325 | ENST00000546087 | C6orf89 | chr6 | 36894637 | + | SOD2 | chr6 | 160100839 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for C6orf89-SOD2 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for C6orf89-SOD2 |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:36894637/:160100839) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for C6orf89-SOD2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for C6orf89-SOD2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for C6orf89-SOD2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for C6orf89-SOD2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0033578 | Prostatic Neoplasms | 8 | CTD_human | |
Tgene | C0376358 | Malignant neoplasm of prostate | 8 | CTD_human | |
Tgene | C0235874 | Disease Exacerbation | 7 | CTD_human | |
Tgene | C0006826 | Malignant Neoplasms | 6 | CTD_human | |
Tgene | C0027626 | Neoplasm Invasiveness | 6 | CTD_human | |
Tgene | C0027651 | Neoplasms | 6 | CTD_human | |
Tgene | C0035126 | Reperfusion Injury | 6 | CTD_human | |
Tgene | C0086692 | Benign Neoplasm | 6 | CTD_human | |
Tgene | C0007621 | Neoplastic Cell Transformation | 5 | CTD_human | |
Tgene | C0018801 | Heart failure | 5 | CTD_human | |
Tgene | C0018802 | Congestive heart failure | 5 | CTD_human | |
Tgene | C0023212 | Left-Sided Heart Failure | 5 | CTD_human | |
Tgene | C0235527 | Heart Failure, Right-Sided | 5 | CTD_human | |
Tgene | C1959583 | Myocardial Failure | 5 | CTD_human | |
Tgene | C1961112 | Heart Decompensation | 5 | CTD_human | |
Tgene | C0006142 | Malignant neoplasm of breast | 4 | CTD_human | |
Tgene | C0007114 | Malignant neoplasm of skin | 4 | CTD_human | |
Tgene | C0024623 | Malignant neoplasm of stomach | 4 | CTD_human | |
Tgene | C0025500 | Mesothelioma | 4 | CTD_human | |
Tgene | C0027627 | Neoplasm Metastasis | 4 | CTD_human | |
Tgene | C0036341 | Schizophrenia | 4 | PSYGENET | |
Tgene | C0037286 | Skin Neoplasms | 4 | CTD_human | |
Tgene | C0038356 | Stomach Neoplasms | 4 | CTD_human | |
Tgene | C0678222 | Breast Carcinoma | 4 | CTD_human | |
Tgene | C1257931 | Mammary Neoplasms, Human | 4 | CTD_human | |
Tgene | C1458155 | Mammary Neoplasms | 4 | CTD_human | |
Tgene | C1708349 | Hereditary Diffuse Gastric Cancer | 4 | CTD_human | |
Tgene | C2239176 | Liver carcinoma | 4 | CTD_human | |
Tgene | C4704874 | Mammary Carcinoma, Human | 4 | CTD_human | |
Tgene | C0003873 | Rheumatoid Arthritis | 3 | CTD_human | |
Tgene | C0007786 | Brain Ischemia | 3 | CTD_human | |
Tgene | C0020538 | Hypertensive disease | 3 | CTD_human | |
Tgene | C0024232 | Lymphatic Metastasis | 3 | CTD_human | |
Tgene | C0028754 | Obesity | 3 | CTD_human | |
Tgene | C0029408 | Degenerative polyarthritis | 3 | CTD_human | |
Tgene | C0030567 | Parkinson Disease | 3 | CTD_human | |
Tgene | C0086743 | Osteoarthrosis Deformans | 3 | CTD_human | |
Tgene | C0270715 | Degenerative Diseases, Central Nervous System | 3 | CTD_human | |
Tgene | C0524851 | Neurodegenerative Disorders | 3 | CTD_human | |
Tgene | C0751733 | Degenerative Diseases, Spinal Cord | 3 | CTD_human | |
Tgene | C0917798 | Cerebral Ischemia | 3 | CTD_human | |
Tgene | C0002152 | Alloxan Diabetes | 2 | CTD_human | |
Tgene | C0002896 | Sideroblastic anemia | 2 | CTD_human | |
Tgene | C0003129 | Anoxemia | 2 | CTD_human | |
Tgene | C0003130 | Anoxia | 2 | CTD_human | |
Tgene | C0004153 | Atherosclerosis | 2 | CTD_human | |
Tgene | C0005586 | Bipolar Disorder | 2 | PSYGENET | |
Tgene | C0005684 | Malignant neoplasm of urinary bladder | 2 | CTD_human | |
Tgene | C0005695 | Bladder Neoplasm | 2 | CTD_human | |
Tgene | C0007097 | Carcinoma | 2 | CTD_human | |
Tgene | C0007131 | Non-Small Cell Lung Carcinoma | 2 | CTD_human | |
Tgene | C0007137 | Squamous cell carcinoma | 2 | CTD_human | |
Tgene | C0007193 | Cardiomyopathy, Dilated | 2 | CTD_human | |
Tgene | C0009402 | Colorectal Carcinoma | 2 | CTD_human | |
Tgene | C0009404 | Colorectal Neoplasms | 2 | CTD_human | |
Tgene | C0011853 | Diabetes Mellitus, Experimental | 2 | CTD_human | |
Tgene | C0014859 | Esophageal Neoplasms | 2 | CTD_human | |
Tgene | C0022116 | Ischemia | 2 | CTD_human | |
Tgene | C0022658 | Kidney Diseases | 2 | CTD_human | |
Tgene | C0026640 | Mouth Neoplasms | 2 | CTD_human | |
Tgene | C0027540 | Necrosis | 2 | CTD_human | |
Tgene | C0032927 | Precancerous Conditions | 2 | CTD_human | |
Tgene | C0034535 | Radiation Syndrome | 2 | CTD_human | |
Tgene | C0038433 | Streptozotocin Diabetes | 2 | CTD_human | |
Tgene | C0042164 | Uveitis | 2 | CTD_human | |
Tgene | C0085207 | Gestational Diabetes | 2 | CTD_human | |
Tgene | C0153381 | Malignant neoplasm of mouth | 2 | CTD_human | |
Tgene | C0162674 | Chronic progressive external ophthalmoplegia | 2 | CTD_human | |
Tgene | C0205696 | Anaplastic carcinoma | 2 | CTD_human | |
Tgene | C0205697 | Carcinoma, Spindle-Cell | 2 | CTD_human | |
Tgene | C0205698 | Undifferentiated carcinoma | 2 | CTD_human | |
Tgene | C0205699 | Carcinomatosis | 2 | CTD_human | |
Tgene | C0242184 | Hypoxia | 2 | CTD_human | |
Tgene | C0279626 | Squamous cell carcinoma of esophagus | 2 | CTD_human | |
Tgene | C0282313 | Condition, Preneoplastic | 2 | CTD_human | |
Tgene | C0546837 | Malignant neoplasm of esophagus | 2 | CTD_human | |
Tgene | C0700292 | Hypoxemia | 2 | CTD_human | |
Tgene | C0919267 | ovarian neoplasm | 2 | CTD_human | |
Tgene | C1140680 | Malignant neoplasm of ovary | 2 | CTD_human | |
Tgene | C1449563 | Cardiomyopathy, Familial Idiopathic | 2 | CTD_human | |
Tgene | C1510432 | Radiation Sickness | 2 | CTD_human | |
Tgene | C1563937 | Atherogenesis | 2 | CTD_human | |
Tgene | C0001418 | Adenocarcinoma | 1 | CTD_human | |
Tgene | C0001787 | Osteoporosis, Age-Related | 1 | CTD_human | |
Tgene | C0001925 | Albuminuria | 1 | CTD_human | |
Tgene | C0001969 | Alcoholic Intoxication | 1 | PSYGENET | |
Tgene | C0002390 | Extrinsic allergic alveolitis | 1 | CTD_human | |
Tgene | C0002395 | Alzheimer's Disease | 1 | CTD_human | |
Tgene | C0002736 | Amyotrophic Lateral Sclerosis | 1 | CTD_human | |
Tgene | C0002871 | Anemia | 1 | CTD_human | |
Tgene | C0003493 | Aortic Diseases | 1 | CTD_human | |
Tgene | C0004045 | Asphyxia Neonatorum | 1 | CTD_human | |
Tgene | C0004364 | Autoimmune Diseases | 1 | CTD_human | |
Tgene | C0006118 | Brain Neoplasms | 1 | CTD_human | |
Tgene | C0007102 | Malignant tumor of colon | 1 | CTD_human | |
Tgene | C0007134 | Renal Cell Carcinoma | 1 | CTD_human | |
Tgene | C0007682 | CNS disorder | 1 | CTD_human | |
Tgene | C0007787 | Transient Ischemic Attack | 1 | CTD_human | |
Tgene | C0009375 | Colonic Neoplasms | 1 | CTD_human | |
Tgene | C0011265 | Presenile dementia | 1 | CTD_human | |
Tgene | C0011570 | Mental Depression | 1 | PSYGENET | |
Tgene | C0011574 | Involutional Depression | 1 | CTD_human | |
Tgene | C0011581 | Depressive disorder | 1 | PSYGENET | |
Tgene | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human | |
Tgene | C0011881 | Diabetic Nephropathy | 1 | CTD_human | |
Tgene | C0014866 | Esophageal Stenosis | 1 | CTD_human | |
Tgene | C0014868 | Esophagitis | 1 | CTD_human | |
Tgene | C0015695 | Fatty Liver | 1 | CTD_human | |
Tgene | C0015967 | Fever | 1 | CTD_human | |
Tgene | C0016059 | Fibrosis | 1 | CTD_human | |
Tgene | C0017667 | Nodular glomerulosclerosis | 1 | CTD_human | |
Tgene | C0018200 | Granuloma, Respiratory Tract | 1 | CTD_human | |
Tgene | C0018800 | Cardiomegaly | 1 | CTD_human | |
Tgene | C0019193 | Hepatitis, Toxic | 1 | CTD_human | |
Tgene | C0020542 | Pulmonary Hypertension | 1 | CTD_human | |
Tgene | C0020550 | Hyperthyroidism | 1 | CTD_human | |
Tgene | C0020615 | Hypoglycemia | 1 | CTD_human | |
Tgene | C0021364 | Male infertility | 1 | CTD_human | |
Tgene | C0021367 | Mammary Ductal Carcinoma | 1 | CTD_human | |
Tgene | C0021655 | Insulin Resistance | 1 | CTD_human | |
Tgene | C0022333 | Jacksonian Seizure | 1 | CTD_human | |
Tgene | C0022665 | Kidney Neoplasm | 1 | CTD_human | |
Tgene | C0022672 | Acute Kidney Tubular Necrosis | 1 | CTD_human | |
Tgene | C0023891 | Liver Cirrhosis, Alcoholic | 1 | CTD_human | |
Tgene | C0024115 | Lung diseases | 1 | CTD_human | |
Tgene | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human | |
Tgene | C0024796 | Marfan Syndrome | 1 | CTD_human | |
Tgene | C0025312 | Meningomyelocele | 1 | CTD_human | |
Tgene | C0026764 | Multiple Myeloma | 1 | CTD_human | |
Tgene | C0027051 | Myocardial Infarction | 1 | CTD_human | |
Tgene | C0027726 | Nephrotic Syndrome | 1 | CTD_human | |
Tgene | C0027746 | Nerve Degeneration | 1 | CTD_human | |
Tgene | C0029456 | Osteoporosis | 1 | CTD_human | |
Tgene | C0029459 | Osteoporosis, Senile | 1 | CTD_human | |
Tgene | C0030246 | Pustulosis of Palms and Soles | 1 | CTD_human | |
Tgene | C0030297 | Pancreatic Neoplasm | 1 | CTD_human | |
Tgene | C0030354 | Papilloma | 1 | CTD_human | |
Tgene | C0032580 | Adenomatous Polyposis Coli | 1 | CTD_human | |
Tgene | C0033141 | Cardiomyopathies, Primary | 1 | CTD_human | |
Tgene | C0033860 | Psoriasis | 1 | CTD_human | |
Tgene | C0033937 | Psychoses, Drug | 1 | CTD_human | |
Tgene | C0033941 | Psychoses, Substance-Induced | 1 | CTD_human | |
Tgene | C0035222 | Respiratory Distress Syndrome, Adult | 1 | CTD_human | |
Tgene | C0036202 | Sarcoidosis | 1 | CTD_human | |
Tgene | C0036529 | Myocardial Diseases, Secondary | 1 | CTD_human | |
Tgene | C0036572 | Seizures | 1 | CTD_human | |
Tgene | C0036980 | Shock, Cardiogenic | 1 | CTD_human | |
Tgene | C0037268 | Skin Abnormalities | 1 | CTD_human | |
Tgene | C0037274 | Dermatologic disorders | 1 | CTD_human | |
Tgene | C0040411 | Tongue Neoplasms | 1 | CTD_human | |
Tgene | C0041408 | Turner Syndrome | 1 | CTD_human | |
Tgene | C0042373 | Vascular Diseases | 1 | CTD_human | |
Tgene | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human | |
Tgene | C0086664 | Myelocele | 1 | CTD_human | |
Tgene | C0149958 | Complex partial seizures | 1 | CTD_human | |
Tgene | C0151526 | Premature Birth | 1 | CTD_human | |
Tgene | C0151744 | Myocardial Ischemia | 1 | CTD_human | |
Tgene | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human | |
Tgene | C0153349 | Malignant neoplasm of tongue | 1 | CTD_human | |
Tgene | C0153633 | Malignant neoplasm of brain | 1 | CTD_human | |
Tgene | C0162309 | Adrenoleukodystrophy | 1 | CTD_human | |
Tgene | C0162671 | MELAS Syndrome | 1 | CTD_human | |
Tgene | C0162871 | Aortic Aneurysm, Abdominal | 1 | CTD_human | |
Tgene | C0205641 | Adenocarcinoma, Basal Cell | 1 | CTD_human | |
Tgene | C0205642 | Adenocarcinoma, Oxyphilic | 1 | CTD_human | |
Tgene | C0205643 | Carcinoma, Cribriform | 1 | CTD_human | |
Tgene | C0205644 | Carcinoma, Granular Cell | 1 | CTD_human | |
Tgene | C0205645 | Adenocarcinoma, Tubular | 1 | CTD_human | |
Tgene | C0205874 | Papilloma, Squamous Cell | 1 | CTD_human | |
Tgene | C0205875 | Papillomatosis | 1 | CTD_human | |
Tgene | C0206061 | Pneumonia, Interstitial | 1 | CTD_human | |
Tgene | C0206062 | Lung Diseases, Interstitial | 1 | CTD_human | |
Tgene | C0206160 | Reticulocytosis | 1 | CTD_human | |
Tgene | C0234533 | Generalized seizures | 1 | CTD_human | |
Tgene | C0234535 | Clonic Seizures | 1 | CTD_human | |
Tgene | C0235974 | Pancreatic carcinoma | 1 | CTD_human | |
Tgene | C0238281 | Middle Cerebral Artery Syndrome | 1 | CTD_human | |
Tgene | C0238461 | Anaplastic thyroid carcinoma | 1 | CTD_human | |
Tgene | C0242526 | Gonadal Dysgenesis, 45,X | 1 | CTD_human | |
Tgene | C0242698 | Ventricular Dysfunction, Left | 1 | CTD_human | |
Tgene | C0242992 | Multiple Chemical Sensitivity | 1 | CTD_human | |
Tgene | C0268255 | Farber Lipogranulomatosis | 1 | CTD_human | |
Tgene | C0268583 | Methylmalonic acidemia | 1 | CTD_human | |
Tgene | C0270824 | Visual seizure | 1 | CTD_human | |
Tgene | C0270844 | Tonic Seizures | 1 | CTD_human | |
Tgene | C0270846 | Epileptic drop attack | 1 | CTD_human | |
Tgene | C0271708 | Fasting Hypoglycemia | 1 | CTD_human | |
Tgene | C0271710 | Reactive hypoglycemia | 1 | CTD_human | |
Tgene | C0274861 | Arsenic Poisoning, Inorganic | 1 | CTD_human | |
Tgene | C0274862 | Nervous System, Organic Arsenic Poisoning | 1 | CTD_human | |
Tgene | C0276496 | Familial Alzheimer Disease (FAD) | 1 | CTD_human | |
Tgene | C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | CTD_human | |
Tgene | C0311375 | Arsenic Poisoning | 1 | CTD_human | |
Tgene | C0345967 | Malignant mesothelioma | 1 | CTD_human | |
Tgene | C0346647 | Malignant neoplasm of pancreas | 1 | CTD_human | |
Tgene | C0376618 | Endotoxemia | 1 | CTD_human | |
Tgene | C0393554 | Amyotrophic Lateral Sclerosis With Dementia | 1 | CTD_human | |
Tgene | C0422850 | Seizures, Somatosensory | 1 | CTD_human | |
Tgene | C0422852 | Seizures, Auditory | 1 | CTD_human | |
Tgene | C0422853 | Olfactory seizure | 1 | CTD_human | |
Tgene | C0422854 | Gustatory seizure | 1 | CTD_human | |
Tgene | C0422855 | Vertiginous seizure | 1 | CTD_human | |
Tgene | C0472381 | Posterior Circulation Transient Ischemic Attack | 1 | CTD_human | |
Tgene | C0494463 | Alzheimer Disease, Late Onset | 1 | CTD_human | |
Tgene | C0494475 | Tonic - clonic seizures | 1 | CTD_human | |
Tgene | C0496899 | Benign neoplasm of brain, unspecified | 1 | CTD_human | |
Tgene | C0520459 | Necrotizing Enterocolitis | 1 | CTD_human | |
Tgene | C0543859 | Amyotrophic Lateral Sclerosis, Guam Form | 1 | CTD_human | |
Tgene | C0546126 | Acute Confusional Senile Dementia | 1 | CTD_human | |
Tgene | C0740376 | Middle Cerebral Artery Thrombosis | 1 | CTD_human | |
Tgene | C0740391 | Middle Cerebral Artery Occlusion | 1 | CTD_human | |
Tgene | C0740392 | Infarction, Middle Cerebral Artery | 1 | CTD_human | |
Tgene | C0740457 | Malignant neoplasm of kidney | 1 | CTD_human | |
Tgene | C0750900 | Alzheimer's Disease, Focal Onset | 1 | CTD_human | |
Tgene | C0750901 | Alzheimer Disease, Early Onset | 1 | CTD_human | |
Tgene | C0750974 | Brain Tumor, Primary | 1 | CTD_human | |
Tgene | C0750977 | Recurrent Brain Neoplasm | 1 | CTD_human | |
Tgene | C0750979 | Primary malignant neoplasm of brain | 1 | CTD_human | |
Tgene | C0751019 | Carotid Circulation Transient Ischemic Attack | 1 | CTD_human | |
Tgene | C0751020 | Transient Ischemic Attack, Vertebrobasilar Circulation | 1 | CTD_human | |
Tgene | C0751021 | Crescendo Transient Ischemic Attacks | 1 | CTD_human | |
Tgene | C0751022 | Brain Stem Ischemia, Transient | 1 | CTD_human | |
Tgene | C0751056 | Non-epileptic convulsion | 1 | CTD_human | |
Tgene | C0751110 | Single Seizure | 1 | CTD_human | |
Tgene | C0751123 | Atonic Absence Seizures | 1 | CTD_human | |
Tgene | C0751316 | Acquired Meningomyelocele | 1 | CTD_human | |
Tgene | C0751406 | Post-Traumatic Osteoporosis | 1 | CTD_human | |
Tgene | C0751494 | Convulsive Seizures | 1 | CTD_human | |
Tgene | C0751495 | Seizures, Focal | 1 | CTD_human | |
Tgene | C0751496 | Seizures, Sensory | 1 | CTD_human | |
Tgene | C0751651 | Mitochondrial Diseases | 1 | CTD_human | |
Tgene | C0751845 | Middle Cerebral Artery Embolus | 1 | CTD_human | |
Tgene | C0751846 | Left Middle Cerebral Artery Infarction | 1 | CTD_human | |
Tgene | C0751847 | Embolic Infarction, Middle Cerebral Artery | 1 | CTD_human | |
Tgene | C0751848 | Thrombotic Infarction, Middle Cerebral Artery | 1 | CTD_human | |
Tgene | C0751849 | Right Middle Cerebral Artery Infarction | 1 | CTD_human | |
Tgene | C0751851 | Arsenic Encephalopathy | 1 | CTD_human | |
Tgene | C0751852 | Arsenic Induced Polyneuropathy | 1 | CTD_human | |
Tgene | C0752347 | Lewy Body Disease | 1 | CTD_human | |
Tgene | C0848676 | Subfertility, Male | 1 | CTD_human | |
Tgene | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human | |
Tgene | C0878544 | Cardiomyopathies | 1 | CTD_human | |
Tgene | C0917731 | Male sterility | 1 | CTD_human | |
Tgene | C0917805 | Transient Cerebral Ischemia | 1 | CTD_human | |
Tgene | C0920563 | Insulin Sensitivity | 1 | CTD_human | |
Tgene | C0948089 | Acute Coronary Syndrome | 1 | CTD_human | |
Tgene | C0949855 | Electron Transport Chain Deficiencies, Mitochondrial | 1 | CTD_human | |
Tgene | C0949856 | Oxidative Phosphorylation Deficiencies | 1 | CTD_human | |
Tgene | C0949857 | Mitochondrial Respiratory Chain Deficiencies | 1 | CTD_human | |
Tgene | C1134719 | Invasive Ductal Breast Carcinoma | 1 | CTD_human | |
Tgene | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human | |
Tgene | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human | |
Tgene | C1266042 | Chromophobe Renal Cell Carcinoma | 1 | CTD_human | |
Tgene | C1266043 | Sarcomatoid Renal Cell Carcinoma | 1 | CTD_human | |
Tgene | C1266044 | Collecting Duct Carcinoma of the Kidney | 1 | CTD_human | |
Tgene | C1269683 | Major Depressive Disorder | 1 | CTD_human | |
Tgene | C1306837 | Papillary Renal Cell Carcinoma | 1 | CTD_human | |
Tgene | C1383860 | Cardiac Hypertrophy | 1 | CTD_human | |
Tgene | C1527168 | Bonnevie-Ullrich Syndrome | 1 | CTD_human | |
Tgene | C1527231 | Adrenomyeloneuropathy | 1 | CTD_human | |
Tgene | C1527335 | Transient Ischemic Attack, Anterior Circulation | 1 | CTD_human | |
Tgene | C1527390 | Neoplasms, Intracranial | 1 | CTD_human | |
Tgene | C1571983 | Involutional paraphrenia | 1 | CTD_human | |
Tgene | C1571984 | Psychosis, Involutional | 1 | CTD_human | |
Tgene | C1623038 | Cirrhosis | 1 | CTD_human | |
Tgene | C1855119 | Methylmalonic aciduria | 1 | CTD_human | |
Tgene | C1859317 | Cataract and cardiomyopathy | 1 | CTD_human | |
Tgene | C2711227 | Steatohepatitis | 1 | CTD_human | |
Tgene | C2713442 | Polyposis, Adenomatous Intestinal | 1 | CTD_human | |
Tgene | C2713443 | Familial Intestinal Polyposis | 1 | CTD_human | |
Tgene | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human | |
Tgene | C3495874 | Nonepileptic Seizures | 1 | CTD_human | |
Tgene | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human | |
Tgene | C3714618 | Primary Hyperthyroidism | 1 | CTD_human | |
Tgene | C4048158 | Convulsions | 1 | CTD_human | |
Tgene | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human | |
Tgene | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human | |
Tgene | C4316903 | Absence Seizures | 1 | CTD_human | |
Tgene | C4317109 | Epileptic Seizures | 1 | CTD_human | |
Tgene | C4317123 | Myoclonic Seizures | 1 | CTD_human | |
Tgene | C4505436 | Generalized Absence Seizures | 1 | CTD_human | |
Tgene | C4551650 | Esophageal Stricture | 1 | CTD_human | |
Tgene | C4721453 | Peripheral Nervous System Diseases | 1 | CTD_human | |
Tgene | C4721845 | Marfan Syndrome, Type I | 1 | CTD_human |