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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:FGB-ALDH2 (FusionGDB2 ID:HG2244TG217) |
Fusion Gene Summary for FGB-ALDH2 |
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Fusion gene information | Fusion gene name: FGB-ALDH2 | Fusion gene ID: hg2244tg217 | Hgene | Tgene | Gene symbol | FGB | ALDH2 | Gene ID | 2244 | 217 |
Gene name | fibrinogen beta chain | aldehyde dehydrogenase 2 family member | |
Synonyms | HEL-S-78p | ALDH-E2|ALDHI|ALDM | |
Cytomap | ('FGB')('ALDH2') 4q31.3 | 12q24.12 | |
Type of gene | protein-coding | protein-coding | |
Description | fibrinogen beta chainbeta-fibrinogenepididymis secretory sperm binding protein Li 78pfibrinogen, B beta polypeptide | aldehyde dehydrogenase, mitochondrialALDH class 2acetaldehyde dehydrogenase 2aldehyde dehydrogenase 2 family (mitochondrial)epididymis secretory sperm binding proteinliver mitochondrial ALDHnucleus-encoded mitochondrial aldehyde dehydrogenase 2 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P02675 | P05091 | |
Ensembl transtripts involved in fusion gene | ENST00000502545, ENST00000302068, ENST00000509493, | ||
Fusion gene scores | * DoF score | 10 X 8 X 4=320 | 6 X 9 X 7=378 |
# samples | 11 | 8 | |
** MAII score | log2(11/320*10)=-1.5405683813627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/378*10)=-2.24031432933371 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FGB [Title/Abstract] AND ALDH2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | FGB(155487717)-ALDH2(112227639), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | FGB-ALDH2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. FGB-ALDH2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. FGB-ALDH2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FGB | GO:0007160 | cell-matrix adhesion | 10903502 |
Hgene | FGB | GO:0031639 | plasminogen activation | 16846481 |
Hgene | FGB | GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 8100742 |
Hgene | FGB | GO:0034622 | cellular protein-containing complex assembly | 8910396 |
Hgene | FGB | GO:0042730 | fibrinolysis | 16846481 |
Hgene | FGB | GO:0043152 | induction of bacterial agglutination | 24367264 |
Hgene | FGB | GO:0045907 | positive regulation of vasoconstriction | 15739255 |
Hgene | FGB | GO:0045921 | positive regulation of exocytosis | 19193866 |
Hgene | FGB | GO:0050714 | positive regulation of protein secretion | 19193866 |
Hgene | FGB | GO:0051258 | protein polymerization | 12706644 |
Hgene | FGB | GO:0051592 | response to calcium ion | 6777381 |
Hgene | FGB | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10903502|19193866 |
Hgene | FGB | GO:0070527 | platelet aggregation | 6281794 |
Hgene | FGB | GO:0072378 | blood coagulation, fibrin clot formation | 16846481 |
Hgene | FGB | GO:0090277 | positive regulation of peptide hormone secretion | 19193866 |
Hgene | FGB | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 10903502 |
Hgene | FGB | GO:2000352 | negative regulation of endothelial cell apoptotic process | 10903502 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | Non-Cancer | TCGA-DD-A1EL-11A | FGB | chr4 | 155487717 | + | ALDH2 | chr12 | 112227639 | + |
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Fusion Gene ORF analysis for FGB-ALDH2 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000502545 | ENST00000261733 | FGB | chr4 | 155487717 | + | ALDH2 | chr12 | 112227639 | + |
3UTR-3CDS | ENST00000502545 | ENST00000416293 | FGB | chr4 | 155487717 | + | ALDH2 | chr12 | 112227639 | + |
Frame-shift | ENST00000302068 | ENST00000261733 | FGB | chr4 | 155487717 | + | ALDH2 | chr12 | 112227639 | + |
Frame-shift | ENST00000302068 | ENST00000416293 | FGB | chr4 | 155487717 | + | ALDH2 | chr12 | 112227639 | + |
intron-3CDS | ENST00000509493 | ENST00000261733 | FGB | chr4 | 155487717 | + | ALDH2 | chr12 | 112227639 | + |
intron-3CDS | ENST00000509493 | ENST00000416293 | FGB | chr4 | 155487717 | + | ALDH2 | chr12 | 112227639 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for FGB-ALDH2 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for FGB-ALDH2 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:155487717/:112227639) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
FGB | ALDH2 |
FUNCTION: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for FGB-ALDH2 |
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Fusion Gene PPI Analysis for FGB-ALDH2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FGB-ALDH2 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | FGB | P02675 | DB11311 | Prothrombin | Cleavage | Biotech | Approved |
Hgene | FGB | P02675 | DB11571 | Human thrombin | Activator | Biotech | Approved |
Hgene | FGB | P02675 | DB11572 | Thrombin alfa | Activator | Biotech | Approved |
Hgene | FGB | P02675 | DB11300 | Thrombin | Activator | Biotech | Approved|Investigational |
Hgene | FGB | P02675 | DB13151 | Anti-inhibitor coagulant complex | Cleavage | Biotech | Approved|Investigational |
Tgene | ALDH2 | P05091 | DB00536 | Guanidine | Inhibitor | Small molecule | Approved |
Tgene | ALDH2 | P05091 | DB00536 | Guanidine | Inhibitor | Small molecule | Approved |
Tgene | ALDH2 | P05091 | DB00822 | Disulfiram | Inhibitor | Small molecule | Approved |
Tgene | ALDH2 | P05091 | DB00822 | Disulfiram | Inhibitor | Small molecule | Approved |
Tgene | ALDH2 | P05091 | DB00157 | NADH | Small molecule | Approved|Nutraceutical | |
Tgene | ALDH2 | P05091 | DB00157 | NADH | Small molecule | Approved|Nutraceutical |
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Related Diseases for FGB-ALDH2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FGB | C2584774 | Congenital hypofibrinogenemia | 7 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | FGB | C0272350 | Dysfibrinogenemia, Congenital | 4 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | FGB | C0001787 | Osteoporosis, Age-Related | 1 | CTD_human |
Hgene | FGB | C0029456 | Osteoporosis | 1 | CTD_human |
Hgene | FGB | C0029459 | Osteoporosis, Senile | 1 | CTD_human |
Hgene | FGB | C0030567 | Parkinson Disease | 1 | CTD_human |
Hgene | FGB | C0751406 | Post-Traumatic Osteoporosis | 1 | CTD_human |
Tgene | C0001973 | Alcoholic Intoxication, Chronic | 7 | CTD_human;PSYGENET | |
Tgene | C0085762 | Alcohol abuse | 7 | CTD_human;PSYGENET | |
Tgene | C0001969 | Alcoholic Intoxication | 5 | PSYGENET | |
Tgene | C0393756 | Hangover from alcohol | 4 | PSYGENET | |
Tgene | C0236664 | Alcohol-Related Disorders | 3 | PSYGENET | |
Tgene | C0001956 | Alcohol Use Disorder | 2 | CTD_human | |
Tgene | C0004096 | Asthma | 2 | CTD_human | |
Tgene | C0005586 | Bipolar Disorder | 2 | PSYGENET | |
Tgene | C0279626 | Squamous cell carcinoma of esophagus | 2 | CTD_human | |
Tgene | C0009402 | Colorectal Carcinoma | 1 | CTD_human | |
Tgene | C0009404 | Colorectal Neoplasms | 1 | CTD_human | |
Tgene | C0014859 | Esophageal Neoplasms | 1 | CTD_human | |
Tgene | C0016382 | Flushing | 1 | CTD_human | |
Tgene | C0016689 | Freckles | 1 | CTD_human | |
Tgene | C0021364 | Male infertility | 1 | CTD_human | |
Tgene | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human | |
Tgene | C0025209 | Melanosis | 1 | CTD_human | |
Tgene | C0025218 | Chloasma | 1 | CTD_human | |
Tgene | C0028796 | Dermatitis, Occupational | 1 | CTD_human | |
Tgene | C0032927 | Precancerous Conditions | 1 | CTD_human | |
Tgene | C0042373 | Vascular Diseases | 1 | CTD_human | |
Tgene | C0086457 | Industrial Dermatosis | 1 | CTD_human | |
Tgene | C0236970 | Alcohol-Induced Disorders | 1 | CTD_human | |
Tgene | C0242973 | Ventricular Dysfunction | 1 | CTD_human | |
Tgene | C0282313 | Condition, Preneoplastic | 1 | CTD_human | |
Tgene | C0342257 | Complications of Diabetes Mellitus | 1 | CTD_human | |
Tgene | C0349464 | Wernicke-Korsakoff Syndrome | 1 | PSYGENET | |
Tgene | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human | |
Tgene | C0520459 | Necrotizing Enterocolitis | 1 | CTD_human | |
Tgene | C0546837 | Malignant neoplasm of esophagus | 1 | CTD_human | |
Tgene | C0848676 | Subfertility, Male | 1 | CTD_human | |
Tgene | C0917731 | Male sterility | 1 | CTD_human | |
Tgene | C2674838 | ALCOHOL SENSITIVITY, ACUTE | 1 | CTD_human | |
Tgene | C3241937 | Nonalcoholic Steatohepatitis | 1 | CTD_human |