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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FGB-LINC00907 (FusionGDB2 ID:HG2244TG284260)

Fusion Gene Summary for FGB-LINC00907

check button Fusion gene summary
Fusion gene informationFusion gene name: FGB-LINC00907
Fusion gene ID: hg2244tg284260
HgeneTgene
Gene symbol

FGB

LINC00907

Gene ID

2244

284260

Gene namefibrinogen beta chainlong intergenic non-protein coding RNA 907
SynonymsHEL-S-78p-
Cytomap('FGB')('LINC00907')

4q31.3

18q12.3

Type of geneprotein-codingncRNA
Descriptionfibrinogen beta chainbeta-fibrinogenepididymis secretory sperm binding protein Li 78pfibrinogen, B beta polypeptide-
Modification date2020031320200313
UniProtAcc

P02675

.
Ensembl transtripts involved in fusion geneENST00000302068, ENST00000502545, 
ENST00000509493, 
Fusion gene scores* DoF score10 X 8 X 4=3204 X 4 X 1=16
# samples 114
** MAII scorelog2(11/320*10)=-1.5405683813627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FGB [Title/Abstract] AND LINC00907 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFGB(155492238)-LINC00907(39932116), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGB

GO:0007160

cell-matrix adhesion

10903502

HgeneFGB

GO:0031639

plasminogen activation

16846481

HgeneFGB

GO:0034116

positive regulation of heterotypic cell-cell adhesion

8100742

HgeneFGB

GO:0034622

cellular protein-containing complex assembly

8910396

HgeneFGB

GO:0042730

fibrinolysis

16846481

HgeneFGB

GO:0043152

induction of bacterial agglutination

24367264

HgeneFGB

GO:0045907

positive regulation of vasoconstriction

15739255

HgeneFGB

GO:0045921

positive regulation of exocytosis

19193866

HgeneFGB

GO:0050714

positive regulation of protein secretion

19193866

HgeneFGB

GO:0051258

protein polymerization

12706644

HgeneFGB

GO:0051592

response to calcium ion

6777381

HgeneFGB

GO:0070374

positive regulation of ERK1 and ERK2 cascade

10903502|19193866

HgeneFGB

GO:0070527

platelet aggregation

6281794

HgeneFGB

GO:0072378

blood coagulation, fibrin clot formation

16846481

HgeneFGB

GO:0090277

positive regulation of peptide hormone secretion

19193866

HgeneFGB

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

10903502

HgeneFGB

GO:2000352

negative regulation of endothelial cell apoptotic process

10903502



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for FGB-LINC00907

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FGB-LINC00907


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for FGB-LINC00907


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:155492238/:39932116)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGB

P02675

.
FUNCTION: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FGB-LINC00907


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FGB-LINC00907


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FGB-LINC00907


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFGBP02675DB11311ProthrombinCleavageBiotechApproved
HgeneFGBP02675DB11571Human thrombinActivatorBiotechApproved
HgeneFGBP02675DB11572Thrombin alfaActivatorBiotechApproved
HgeneFGBP02675DB11300ThrombinActivatorBiotechApproved|Investigational
HgeneFGBP02675DB13151Anti-inhibitor coagulant complexCleavageBiotechApproved|Investigational

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Related Diseases for FGB-LINC00907


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGBC2584774Congenital hypofibrinogenemia7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGBC0272350Dysfibrinogenemia, Congenital4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGBC0001787Osteoporosis, Age-Related1CTD_human
HgeneFGBC0029456Osteoporosis1CTD_human
HgeneFGBC0029459Osteoporosis, Senile1CTD_human
HgeneFGBC0030567Parkinson Disease1CTD_human
HgeneFGBC0751406Post-Traumatic Osteoporosis1CTD_human