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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FGB-HP (FusionGDB2 ID:HG2244TG3240)

Fusion Gene Summary for FGB-HP

check button Fusion gene summary
Fusion gene informationFusion gene name: FGB-HP
Fusion gene ID: hg2244tg3240
HgeneTgene
Gene symbol

FGB

HP

Gene ID

2244

3240

Gene namefibrinogen beta chainhaptoglobin
SynonymsHEL-S-78pBP|HP2ALPHA2|HPA1S
Cytomap('FGB')('HP')

4q31.3

16q22.2

Type of geneprotein-codingprotein-coding
Descriptionfibrinogen beta chainbeta-fibrinogenepididymis secretory sperm binding protein Li 78pfibrinogen, B beta polypeptidehaptoglobinbinding peptidehaptoglobin alpha(1S)-betahaptoglobin alpha(2FS)-betahaptoglobin, alpha polypeptidehaptoglobin, beta polypeptidezonulin
Modification date2020031320200313
UniProtAcc

P02675

P00738

Ensembl transtripts involved in fusion geneENST00000502545, ENST00000302068, 
ENST00000509493, 
Fusion gene scores* DoF score10 X 8 X 4=32014 X 11 X 3=462
# samples 1113
** MAII scorelog2(11/320*10)=-1.5405683813627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/462*10)=-1.8293812283876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGB [Title/Abstract] AND HP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFGB(155489646)-HP(72093016), # samples:1
Anticipated loss of major functional domain due to fusion event.FGB-HP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FGB-HP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FGB-HP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FGB-HP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGB

GO:0007160

cell-matrix adhesion

10903502

HgeneFGB

GO:0031639

plasminogen activation

16846481

HgeneFGB

GO:0034116

positive regulation of heterotypic cell-cell adhesion

8100742

HgeneFGB

GO:0034622

cellular protein-containing complex assembly

8910396

HgeneFGB

GO:0042730

fibrinolysis

16846481

HgeneFGB

GO:0043152

induction of bacterial agglutination

24367264

HgeneFGB

GO:0045907

positive regulation of vasoconstriction

15739255

HgeneFGB

GO:0045921

positive regulation of exocytosis

19193866

HgeneFGB

GO:0050714

positive regulation of protein secretion

19193866

HgeneFGB

GO:0051258

protein polymerization

12706644

HgeneFGB

GO:0051592

response to calcium ion

6777381

HgeneFGB

GO:0070374

positive regulation of ERK1 and ERK2 cascade

10903502|19193866

HgeneFGB

GO:0070527

platelet aggregation

6281794

HgeneFGB

GO:0072378

blood coagulation, fibrin clot formation

16846481

HgeneFGB

GO:0090277

positive regulation of peptide hormone secretion

19193866

HgeneFGB

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

10903502

HgeneFGB

GO:2000352

negative regulation of endothelial cell apoptotic process

10903502

TgeneHP

GO:0010942

positive regulation of cell death

19740759

TgeneHP

GO:0042542

response to hydrogen peroxide

19740759

TgeneHP

GO:0051354

negative regulation of oxidoreductase activity

19740759

TgeneHP

GO:2000296

negative regulation of hydrogen peroxide catabolic process

19740759


check buttonFusion gene breakpoints across FGB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across HP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-G3-A3CI-01AFGBchr4

155489646

+HPchr16

72093016

+


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Fusion Gene ORF analysis for FGB-HP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000502545ENST00000355906FGBchr4

155489646

+HPchr16

72093016

+
3UTR-3CDSENST00000502545ENST00000357763FGBchr4

155489646

+HPchr16

72093016

+
3UTR-3CDSENST00000502545ENST00000398131FGBchr4

155489646

+HPchr16

72093016

+
3UTR-3CDSENST00000502545ENST00000562526FGBchr4

155489646

+HPchr16

72093016

+
3UTR-3CDSENST00000502545ENST00000569639FGBchr4

155489646

+HPchr16

72093016

+
3UTR-3CDSENST00000502545ENST00000570083FGBchr4

155489646

+HPchr16

72093016

+
3UTR-intronENST00000502545ENST00000565574FGBchr4

155489646

+HPchr16

72093016

+
5CDS-intronENST00000302068ENST00000565574FGBchr4

155489646

+HPchr16

72093016

+
5CDS-intronENST00000509493ENST00000565574FGBchr4

155489646

+HPchr16

72093016

+
Frame-shiftENST00000302068ENST00000569639FGBchr4

155489646

+HPchr16

72093016

+
Frame-shiftENST00000509493ENST00000569639FGBchr4

155489646

+HPchr16

72093016

+
In-frameENST00000302068ENST00000355906FGBchr4

155489646

+HPchr16

72093016

+
In-frameENST00000302068ENST00000357763FGBchr4

155489646

+HPchr16

72093016

+
In-frameENST00000302068ENST00000398131FGBchr4

155489646

+HPchr16

72093016

+
In-frameENST00000302068ENST00000562526FGBchr4

155489646

+HPchr16

72093016

+
In-frameENST00000302068ENST00000570083FGBchr4

155489646

+HPchr16

72093016

+
In-frameENST00000509493ENST00000355906FGBchr4

155489646

+HPchr16

72093016

+
In-frameENST00000509493ENST00000357763FGBchr4

155489646

+HPchr16

72093016

+
In-frameENST00000509493ENST00000398131FGBchr4

155489646

+HPchr16

72093016

+
In-frameENST00000509493ENST00000562526FGBchr4

155489646

+HPchr16

72093016

+
In-frameENST00000509493ENST00000570083FGBchr4

155489646

+HPchr16

72093016

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000302068FGBchr4155489646+ENST00000570083HPchr1672093016+1914895631748561
ENST00000302068FGBchr4155489646+ENST00000355906HPchr1672093016+1913895631748561
ENST00000302068FGBchr4155489646+ENST00000398131HPchr1672093016+1913895631748561
ENST00000302068FGBchr4155489646+ENST00000357763HPchr1672093016+1875895631748561
ENST00000302068FGBchr4155489646+ENST00000562526HPchr1672093016+136389563983306
ENST00000509493FGBchr4155489646+ENST00000570083HPchr1672093016+14684491421302386
ENST00000509493FGBchr4155489646+ENST00000355906HPchr1672093016+14674491421302386
ENST00000509493FGBchr4155489646+ENST00000398131HPchr1672093016+14674491421302386
ENST00000509493FGBchr4155489646+ENST00000357763HPchr1672093016+14294491421302386
ENST00000509493FGBchr4155489646+ENST00000562526HPchr1672093016+917449142537131

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000302068ENST00000570083FGBchr4155489646+HPchr1672093016+0.0016910170.998309
ENST00000302068ENST00000355906FGBchr4155489646+HPchr1672093016+0.0017102370.99828976
ENST00000302068ENST00000398131FGBchr4155489646+HPchr1672093016+0.0017102370.99828976
ENST00000302068ENST00000357763FGBchr4155489646+HPchr1672093016+0.0017603430.99823964
ENST00000302068ENST00000562526FGBchr4155489646+HPchr1672093016+0.0007638030.9992362
ENST00000509493ENST00000570083FGBchr4155489646+HPchr1672093016+0.0011207290.99887925
ENST00000509493ENST00000355906FGBchr4155489646+HPchr1672093016+0.0011329090.99886715
ENST00000509493ENST00000398131FGBchr4155489646+HPchr1672093016+0.0011329090.99886715
ENST00000509493ENST00000357763FGBchr4155489646+HPchr1672093016+0.0011870050.99881303
ENST00000509493ENST00000562526FGBchr4155489646+HPchr1672093016+0.315450970.6845491

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Fusion Genomic Features for FGB-HP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FGBchr4155489646+HPchr1672093012+0.0006396960.99936026
FGBchr4155489646+HPchr1672093012+0.0006396960.99936026

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FGB-HP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:155489646/chr16:72093016)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGB

P02675

HP

P00738

FUNCTION: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.FUNCTION: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. {ECO:0000269|PubMed:21248165}.; FUNCTION: The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. {ECO:0000269|PubMed:21248165}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGBchr4:155489646chr16:72093016ENST00000302068+58157_222277492.0Coiled coilOntology_term=ECO:0000305,ECO:0000305,ECO:0000305
HgeneFGBchr4:155489646chr16:72093016ENST00000302068+5845_47277492.0RegionNote=Beta-chain polymerization%2C binding distal domain of another fibrin
TgeneHPchr4:155489646chr16:72093016ENST0000035590647162_404122407.0DomainPeptidase S1
TgeneHPchr4:155489646chr16:72093016ENST0000039813125162_40463348.0DomainPeptidase S1
TgeneHPchr4:155489646chr16:72093016ENST000003981312590_14763348.0DomainSushi 2
TgeneHPchr4:155489646chr16:72093016ENST0000056557405162_4040348.0DomainPeptidase S1
TgeneHPchr4:155489646chr16:72093016ENST000005655740531_880348.0DomainSushi 1
TgeneHPchr4:155489646chr16:72093016ENST000005655740590_1470348.0DomainSushi 2
TgeneHPchr4:155489646chr16:72093016ENST0000057008325162_40463348.0DomainPeptidase S1
TgeneHPchr4:155489646chr16:72093016ENST000005700832590_14763348.0DomainSushi 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGBchr4:155489646chr16:72093016ENST00000302068+58232_488277492.0DomainFibrinogen C-terminal
TgeneHPchr4:155489646chr16:72093016ENST000003559064731_88122407.0DomainSushi 1
TgeneHPchr4:155489646chr16:72093016ENST000003559064790_147122407.0DomainSushi 2
TgeneHPchr4:155489646chr16:72093016ENST000003981312531_8863348.0DomainSushi 1
TgeneHPchr4:155489646chr16:72093016ENST000005700832531_8863348.0DomainSushi 1


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Fusion Gene Sequence for FGB-HP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30142_30142_1_FGB-HP_FGB_chr4_155489646_ENST00000302068_HP_chr16_72093016_ENST00000355906_length(transcript)=1913nt_BP=895nt
GAAGTCATTCCTAGCAGAGGACTCAGATATATATAGGATTGAAGATCTCTCAGTTAAGTCTACATGAAAAGGATGGTTTCTTGGAGCTTC
CACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTGTCAACGACAATGAGGAGGGT
TTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGTGGAGGT
GGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCACGCTGAC
CCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTTGATGAG
TTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAGAGGCAG
AAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAATAGC
AATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGCTCAA
ATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGT
GAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGAGTG
TACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGAAT
CCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCATAAT
CTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAGCG
AAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTCCCAG
GTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGCAGAA
GTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGTGGCT
GACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCATACTG
AATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGACCTG
GAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCC
ATCCAGGACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTGGAAG
AGGGCAAAGTGGACGGGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGCATTGCTGAGTCAATC
AATAAAGAGCTTTCTTTTGACCC

>30142_30142_1_FGB-HP_FGB_chr4_155489646_ENST00000302068_HP_chr16_72093016_ENST00000355906_length(amino acids)=561AA_BP=277
MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAP
DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQ
LYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYC
DMNTENGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLF
LNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDH
LKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAE
YGVYVKVTSIQDWVQKTIAEN

--------------------------------------------------------------
>30142_30142_2_FGB-HP_FGB_chr4_155489646_ENST00000302068_HP_chr16_72093016_ENST00000357763_length(transcript)=1875nt_BP=895nt
GAAGTCATTCCTAGCAGAGGACTCAGATATATATAGGATTGAAGATCTCTCAGTTAAGTCTACATGAAAAGGATGGTTTCTTGGAGCTTC
CACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTGTCAACGACAATGAGGAGGGT
TTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGTGGAGGT
GGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCACGCTGAC
CCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTTGATGAG
TTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAGAGGCAG
AAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAATAGC
AATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGCTCAA
ATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGT
GAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGAGTG
TACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGAAT
CCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCATAAT
CTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAGCG
AAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTCCCAG
GTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGCAGAA
GTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGTGGCT
GACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCATACTG
AATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGACCTG
GAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCC
ATCCAGGACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTGGAAG
AGGGCAAAGTGGACGGGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGC

>30142_30142_2_FGB-HP_FGB_chr4_155489646_ENST00000302068_HP_chr16_72093016_ENST00000357763_length(amino acids)=561AA_BP=277
MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAP
DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQ
LYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYC
DMNTENGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLF
LNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDH
LKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAE
YGVYVKVTSIQDWVQKTIAEN

--------------------------------------------------------------
>30142_30142_3_FGB-HP_FGB_chr4_155489646_ENST00000302068_HP_chr16_72093016_ENST00000398131_length(transcript)=1913nt_BP=895nt
GAAGTCATTCCTAGCAGAGGACTCAGATATATATAGGATTGAAGATCTCTCAGTTAAGTCTACATGAAAAGGATGGTTTCTTGGAGCTTC
CACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTGTCAACGACAATGAGGAGGGT
TTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGTGGAGGT
GGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCACGCTGAC
CCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTTGATGAG
TTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAGAGGCAG
AAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAATAGC
AATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGCTCAA
ATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGT
GAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGAGTG
TACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGAAT
CCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCATAAT
CTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAGCG
AAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTCCCAG
GTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGCAGAA
GTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGTGGCT
GACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCATACTG
AATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGACCTG
GAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCC
ATCCAGGACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTGGAAG
AGGGCAAAGTGGACGGGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGCATTGCTGAGTCAATC
AATAAAGAGCTTTCTTTTGACCC

>30142_30142_3_FGB-HP_FGB_chr4_155489646_ENST00000302068_HP_chr16_72093016_ENST00000398131_length(amino acids)=561AA_BP=277
MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAP
DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQ
LYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYC
DMNTENGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLF
LNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDH
LKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAE
YGVYVKVTSIQDWVQKTIAEN

--------------------------------------------------------------
>30142_30142_4_FGB-HP_FGB_chr4_155489646_ENST00000302068_HP_chr16_72093016_ENST00000562526_length(transcript)=1363nt_BP=895nt
GAAGTCATTCCTAGCAGAGGACTCAGATATATATAGGATTGAAGATCTCTCAGTTAAGTCTACATGAAAAGGATGGTTTCTTGGAGCTTC
CACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTGTCAACGACAATGAGGAGGGT
TTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGTGGAGGT
GGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCACGCTGAC
CCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTTGATGAG
TTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAGAGGCAG
AAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAATAGC
AATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGCTCAA
ATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGT
GAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGAGTG
TACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGCCCATACTGAATGAACACAC
CTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGACCTGGAGGAGGACAC
CTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCCATCCAGGACTG
GGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTGGAAGAGGGCAAAGTG
GACGGGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGCATTGCTGAGTCAATCAATAAAGAGCT
TTCTTTTGACCCA

>30142_30142_4_FGB-HP_FGB_chr4_155489646_ENST00000302068_HP_chr16_72093016_ENST00000562526_length(amino acids)=306AA_BP=277
MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAP
DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQ
LYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYC
DMNTENGGVYTLNNEKQWINKAVGDKLPECEAAHTE

--------------------------------------------------------------
>30142_30142_5_FGB-HP_FGB_chr4_155489646_ENST00000302068_HP_chr16_72093016_ENST00000570083_length(transcript)=1914nt_BP=895nt
GAAGTCATTCCTAGCAGAGGACTCAGATATATATAGGATTGAAGATCTCTCAGTTAAGTCTACATGAAAAGGATGGTTTCTTGGAGCTTC
CACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTGTCAACGACAATGAGGAGGGT
TTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGTGGAGGT
GGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCACGCTGAC
CCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTTGATGAG
TTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAGAGGCAG
AAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAATAGC
AATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGCTCAA
ATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGT
GAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGAGTG
TACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGAAT
CCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCATAAT
CTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAGCG
AAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTCCCAG
GTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGCAGAA
GTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGTGGCT
GACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCATACTG
AATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGACCTG
GAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCC
ATCCAGGACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTGGAAG
AGGGCAAAGTGGACGGGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGCATTGCTGAGTCAATC
AATAAAGAGCTTTCTTTTGACCCA

>30142_30142_5_FGB-HP_FGB_chr4_155489646_ENST00000302068_HP_chr16_72093016_ENST00000570083_length(amino acids)=561AA_BP=277
MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAP
DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQ
LYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYC
DMNTENGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLF
LNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDH
LKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAE
YGVYVKVTSIQDWVQKTIAEN

--------------------------------------------------------------
>30142_30142_6_FGB-HP_FGB_chr4_155489646_ENST00000509493_HP_chr16_72093016_ENST00000355906_length(transcript)=1467nt_BP=449nt
GGATGGTTTCTTGGAGCTTCCACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTG
TCAACGACAATGAGGAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAA
TAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGC
TCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGG
AGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGG
AGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAA
GAATCCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCA
TAATCTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAAC
AGCGAAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTC
CCAGGTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGC
AGAAGTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGT
GGCTGACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCAT
ACTGAATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGA
CCTGGAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGAC
TTCCATCCAGGACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTG
GAAGAGGGCAAAGTGGACGGGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGCATTGCTGAGTC
AATCAATAAAGAGCTTTCTTTTGACCC

>30142_30142_6_FGB-HP_FGB_chr4_155489646_ENST00000509493_HP_chr16_72093016_ENST00000355906_length(amino acids)=386AA_BP=102
MEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKP
YRVYCDMNTENGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTT
AKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANF
KFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKS
CAVAEYGVYVKVTSIQDWVQKTIAEN

--------------------------------------------------------------
>30142_30142_7_FGB-HP_FGB_chr4_155489646_ENST00000509493_HP_chr16_72093016_ENST00000357763_length(transcript)=1429nt_BP=449nt
GGATGGTTTCTTGGAGCTTCCACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTG
TCAACGACAATGAGGAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAA
TAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGC
TCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGG
AGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGG
AGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAA
GAATCCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCA
TAATCTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAAC
AGCGAAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTC
CCAGGTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGC
AGAAGTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGT
GGCTGACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCAT
ACTGAATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGA
CCTGGAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGAC
TTCCATCCAGGACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTG
GAAGAGGGCAAAGTGGACGGGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGC

>30142_30142_7_FGB-HP_FGB_chr4_155489646_ENST00000509493_HP_chr16_72093016_ENST00000357763_length(amino acids)=386AA_BP=102
MEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKP
YRVYCDMNTENGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTT
AKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANF
KFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKS
CAVAEYGVYVKVTSIQDWVQKTIAEN

--------------------------------------------------------------
>30142_30142_8_FGB-HP_FGB_chr4_155489646_ENST00000509493_HP_chr16_72093016_ENST00000398131_length(transcript)=1467nt_BP=449nt
GGATGGTTTCTTGGAGCTTCCACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTG
TCAACGACAATGAGGAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAA
TAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGC
TCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGG
AGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGG
AGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAA
GAATCCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCA
TAATCTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAAC
AGCGAAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTC
CCAGGTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGC
AGAAGTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGT
GGCTGACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCAT
ACTGAATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGA
CCTGGAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGAC
TTCCATCCAGGACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTG
GAAGAGGGCAAAGTGGACGGGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGCATTGCTGAGTC
AATCAATAAAGAGCTTTCTTTTGACCC

>30142_30142_8_FGB-HP_FGB_chr4_155489646_ENST00000509493_HP_chr16_72093016_ENST00000398131_length(amino acids)=386AA_BP=102
MEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKP
YRVYCDMNTENGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTT
AKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANF
KFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKS
CAVAEYGVYVKVTSIQDWVQKTIAEN

--------------------------------------------------------------
>30142_30142_9_FGB-HP_FGB_chr4_155489646_ENST00000509493_HP_chr16_72093016_ENST00000562526_length(transcript)=917nt_BP=449nt
GGATGGTTTCTTGGAGCTTCCACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTG
TCAACGACAATGAGGAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAA
TAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGC
TCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGG
AGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGG
AGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGCCCATACTGAATGAAC
ACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGACCTGGAGGAGG
ACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCCATCCAGG
ACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTGGAAGAGGGCAA
AGTGGACGGGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGCATTGCTGAGTCAATCAATAAAG
AGCTTTCTTTTGACCCA

>30142_30142_9_FGB-HP_FGB_chr4_155489646_ENST00000509493_HP_chr16_72093016_ENST00000562526_length(amino acids)=131AA_BP=102
MEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKP
YRVYCDMNTENGGVYTLNNEKQWINKAVGDKLPECEAAHTE

--------------------------------------------------------------
>30142_30142_10_FGB-HP_FGB_chr4_155489646_ENST00000509493_HP_chr16_72093016_ENST00000570083_length(transcript)=1468nt_BP=449nt
GGATGGTTTCTTGGAGCTTCCACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTG
TCAACGACAATGAGGAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAA
TAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGC
TCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGG
AGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGG
AGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAA
GAATCCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCA
TAATCTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAAC
AGCGAAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTC
CCAGGTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGC
AGAAGTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGT
GGCTGACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCAT
ACTGAATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGA
CCTGGAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGAC
TTCCATCCAGGACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTG
GAAGAGGGCAAAGTGGACGGGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGCATTGCTGAGTC
AATCAATAAAGAGCTTTCTTTTGACCCA

>30142_30142_10_FGB-HP_FGB_chr4_155489646_ENST00000509493_HP_chr16_72093016_ENST00000570083_length(amino acids)=386AA_BP=102
MEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKP
YRVYCDMNTENGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTT
AKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANF
KFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKS
CAVAEYGVYVKVTSIQDWVQKTIAEN

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Fusion Gene PPI Analysis for FGB-HP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneHPchr4:155489646chr16:72093016ENST0000035590647318_323122.33333333333333407.0CD163
TgeneHPchr4:155489646chr16:72093016ENST0000039813125318_32363.333333333333336348.0CD163
TgeneHPchr4:155489646chr16:72093016ENST0000056557405318_3230348.0CD163
TgeneHPchr4:155489646chr16:72093016ENST0000057008325318_32363.333333333333336348.0CD163


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FGB-HP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFGBP02675DB11311ProthrombinCleavageBiotechApproved
HgeneFGBP02675DB11571Human thrombinActivatorBiotechApproved
HgeneFGBP02675DB11572Thrombin alfaActivatorBiotechApproved
HgeneFGBP02675DB11300ThrombinActivatorBiotechApproved|Investigational
HgeneFGBP02675DB13151Anti-inhibitor coagulant complexCleavageBiotechApproved|Investigational
TgeneHPP00738DB14548Zinc sulfate, unspecified formBinderSmall moleculeApproved|Experimental
TgeneHPP00738DB14533Zinc chlorideBinderSmall moleculeApproved|Investigational

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Related Diseases for FGB-HP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGBC2584774Congenital hypofibrinogenemia7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGBC0272350Dysfibrinogenemia, Congenital4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGBC0001787Osteoporosis, Age-Related1CTD_human
HgeneFGBC0029456Osteoporosis1CTD_human
HgeneFGBC0029459Osteoporosis, Senile1CTD_human
HgeneFGBC0030567Parkinson Disease1CTD_human
HgeneFGBC0751406Post-Traumatic Osteoporosis1CTD_human
TgeneC0041696Unipolar Depression4PSYGENET
TgeneC0011570Mental Depression3PSYGENET
TgeneC0011581Depressive disorder3PSYGENET
TgeneC0027051Myocardial Infarction3CTD_human
TgeneC1269683Major Depressive Disorder3PSYGENET
TgeneC0024530Malaria2CTD_human
TgeneC0525045Mood Disorders2PSYGENET
TgeneC0001723Affective Disorders, Psychotic1PSYGENET
TgeneC0002871Anemia1CTD_human
TgeneC0002895Anemia, Sickle Cell1CTD_human
TgeneC0003864Arthritis1CTD_human
TgeneC0004153Atherosclerosis1CTD_human
TgeneC0004364Autoimmune Diseases1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0007222Cardiovascular Diseases1CTD_human
TgeneC0011854Diabetes Mellitus, Insulin-Dependent1CTD_human
TgeneC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneC0011875Diabetic Angiopathies1CTD_human
TgeneC0013221Drug toxicity1CTD_human
TgeneC0016479Food Poisoning1CTD_human
TgeneC0017416Genital Neoplasms, Female1CTD_human
TgeneC0018995Hemochromatosis1CTD_human
TgeneC0019054Hemolysis (disorder)1CTD_human
TgeneC0019163Hepatitis B1CTD_human
TgeneC0019693HIV Infections1CTD_human
TgeneC0020517Hypersensitivity1CTD_human
TgeneC0020538Hypertensive disease1CTD_human
TgeneC0022660Kidney Failure, Acute1CTD_human
TgeneC0023418leukemia1CTD_human
TgeneC0025945Microangiopathy, Diabetic1CTD_human
TgeneC0035305Retinal Detachment1CTD_human
TgeneC0036341Schizophrenia1CTD_human
TgeneC0041296Tuberculosis1CTD_human
TgeneC0041755Adverse reaction to drug1CTD_human
TgeneC0085397Pasteurellaceae Infections1CTD_human
TgeneC0162323Polyarthritis1CTD_human
TgeneC0205734Diabetes, Autoimmune1CTD_human
TgeneC0235574Intravascular hemolysis1CTD_human
TgeneC0242339Dyslipidemias1CTD_human
TgeneC0312854Extravascular Hemolysis1CTD_human
TgeneC0339546Retinal Pigment Epithelial Detachment1CTD_human
TgeneC0341934Transient hypertension of pregnancy1CTD_human
TgeneC0342257Complications of Diabetes Mellitus1CTD_human
TgeneC0342302Brittle diabetes1CTD_human
TgeneC0392514Hereditary hemochromatosis1CTD_human
TgeneC0524909Hepatitis B, Chronic1CTD_human
TgeneC0524910Hepatitis C, Chronic1CTD_human
TgeneC0598784Dyslipoproteinemias1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0679360Foodborne Disease1CTD_human
TgeneC0852036Pregnancy associated hypertension1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1527304Allergic Reaction1CTD_human
TgeneC1563937Atherogenesis1CTD_human
TgeneC1565662Acute Kidney Insufficiency1CTD_human
TgeneC2609414Acute kidney injury1CTD_human
TgeneC3279786ANHAPTOGLOBINEMIA1UNIPROT
TgeneC3837958Diabetes Mellitus, Ketosis-Prone1CTD_human
TgeneC4505456HIV Coinfection1CTD_human
TgeneC4554117Diabetes Mellitus, Sudden-Onset1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human