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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:FGF2-AKT3 (FusionGDB2 ID:HG2247TG10000) |
Fusion Gene Summary for FGF2-AKT3 |
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Fusion gene information | Fusion gene name: FGF2-AKT3 | Fusion gene ID: hg2247tg10000 | Hgene | Tgene | Gene symbol | FGF2 | AKT3 | Gene ID | 2247 | 10000 |
Gene name | fibroblast growth factor 2 | AKT serine/threonine kinase 3 | |
Synonyms | BFGF|FGF-2|FGFB|HBGF-2 | MPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2 | |
Cytomap | ('FGF2')('AKT3') 4q28.1 | 1q43-q44 | |
Type of gene | protein-coding | protein-coding | |
Description | fibroblast growth factor 2basic fibroblast growth factor bFGFfibroblast growth factor 2 (basic)heparin-binding growth factor 2prostatropin | RAC-gamma serine/threonine-protein kinasePKB gammaRAC-gamma serine/threonine protein kinasev-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | |
Modification date | 20200329 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000264498, ENST00000608478, | ||
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 19 X 18 X 8=2736 |
# samples | 2 | 19 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(19/2736*10)=-3.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FGF2 [Title/Abstract] AND AKT3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | FGF2(123748507)-AKT3(243801044), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | FGF2-AKT3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. FGF2-AKT3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. FGF2-AKT3 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FGF2 | GO:0001658 | branching involved in ureteric bud morphogenesis | 12631064 |
Hgene | FGF2 | GO:0001938 | positive regulation of endothelial cell proliferation | 16756958 |
Hgene | FGF2 | GO:0002042 | cell migration involved in sprouting angiogenesis | 18059339 |
Hgene | FGF2 | GO:0006661 | phosphatidylinositol biosynthetic process | 20011604 |
Hgene | FGF2 | GO:0008284 | positive regulation of cell proliferation | 2161540 |
Hgene | FGF2 | GO:0008543 | fibroblast growth factor receptor signaling pathway | 16774925|17500071 |
Hgene | FGF2 | GO:0010764 | negative regulation of fibroblast migration | 19577615 |
Hgene | FGF2 | GO:0010863 | positive regulation of phospholipase C activity | 20011604 |
Hgene | FGF2 | GO:0030214 | hyaluronan catabolic process | 19577615 |
Hgene | FGF2 | GO:0032958 | inositol phosphate biosynthetic process | 20011604 |
Hgene | FGF2 | GO:0042060 | wound healing | 16756958 |
Hgene | FGF2 | GO:0042660 | positive regulation of cell fate specification | 18635606 |
Hgene | FGF2 | GO:0043406 | positive regulation of MAP kinase activity | 16756958 |
Hgene | FGF2 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 18555217|20011604|28302677 |
Hgene | FGF2 | GO:0043537 | negative regulation of blood vessel endothelial cell migration | 18555217 |
Hgene | FGF2 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity | 20011604 |
Hgene | FGF2 | GO:0045766 | positive regulation of angiogenesis | 16774925|20011604|28302677 |
Hgene | FGF2 | GO:0045893 | positive regulation of transcription, DNA-templated | 17500071 |
Hgene | FGF2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 18059339 |
Hgene | FGF2 | GO:0051209 | release of sequestered calcium ion into cytosol | 20011604 |
Hgene | FGF2 | GO:0060045 | positive regulation of cardiac muscle cell proliferation | 9553078 |
Hgene | FGF2 | GO:0060548 | negative regulation of cell death | 12631064 |
Hgene | FGF2 | GO:0060591 | chondroblast differentiation | 17167778 |
Hgene | FGF2 | GO:0061045 | negative regulation of wound healing | 19577615 |
Hgene | FGF2 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 17167778 |
Hgene | FGF2 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis | 28302677 |
Hgene | FGF2 | GO:1903672 | positive regulation of sprouting angiogenesis | 16756958 |
Hgene | FGF2 | GO:2000544 | regulation of endothelial cell chemotaxis to fibroblast growth factor | 16756958 |
Hgene | FGF2 | GO:2000546 | positive regulation of endothelial cell chemotaxis to fibroblast growth factor | 16756958 |
Hgene | FGF2 | GO:2000573 | positive regulation of DNA biosynthetic process | 16774925 |
Tgene | AKT3 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 28254819 |
Tgene | AKT3 | GO:1905564 | positive regulation of vascular endothelial cell proliferation | 28254819 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-BR-A4J7-01A | FGF2 | chr4 | 123748507 | + | AKT3 | chr1 | 243801044 | - |
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Fusion Gene ORF analysis for FGF2-AKT3 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000264498 | ENST00000492957 | FGF2 | chr4 | 123748507 | + | AKT3 | chr1 | 243801044 | - |
5CDS-intron | ENST00000608478 | ENST00000492957 | FGF2 | chr4 | 123748507 | + | AKT3 | chr1 | 243801044 | - |
Frame-shift | ENST00000264498 | ENST00000263826 | FGF2 | chr4 | 123748507 | + | AKT3 | chr1 | 243801044 | - |
Frame-shift | ENST00000264498 | ENST00000336199 | FGF2 | chr4 | 123748507 | + | AKT3 | chr1 | 243801044 | - |
Frame-shift | ENST00000264498 | ENST00000366539 | FGF2 | chr4 | 123748507 | + | AKT3 | chr1 | 243801044 | - |
Frame-shift | ENST00000264498 | ENST00000366540 | FGF2 | chr4 | 123748507 | + | AKT3 | chr1 | 243801044 | - |
Frame-shift | ENST00000608478 | ENST00000263826 | FGF2 | chr4 | 123748507 | + | AKT3 | chr1 | 243801044 | - |
Frame-shift | ENST00000608478 | ENST00000336199 | FGF2 | chr4 | 123748507 | + | AKT3 | chr1 | 243801044 | - |
Frame-shift | ENST00000608478 | ENST00000366539 | FGF2 | chr4 | 123748507 | + | AKT3 | chr1 | 243801044 | - |
Frame-shift | ENST00000608478 | ENST00000366540 | FGF2 | chr4 | 123748507 | + | AKT3 | chr1 | 243801044 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for FGF2-AKT3 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for FGF2-AKT3 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:123748507/:243801044) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for FGF2-AKT3 |
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Fusion Gene PPI Analysis for FGF2-AKT3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FGF2-AKT3 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FGF2-AKT3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FGF2 | C0525045 | Mood Disorders | 3 | PSYGENET |
Hgene | FGF2 | C0151744 | Myocardial Ischemia | 2 | CTD_human |
Hgene | FGF2 | C0008924 | Cleft upper lip | 1 | CTD_human |
Hgene | FGF2 | C0008925 | Cleft Palate | 1 | CTD_human |
Hgene | FGF2 | C0009171 | Cocaine Abuse | 1 | CTD_human |
Hgene | FGF2 | C0011573 | Endogenous depression | 1 | CTD_human |
Hgene | FGF2 | C0011581 | Depressive disorder | 1 | CTD_human |
Hgene | FGF2 | C0014549 | Tonic-Clonic Epilepsy | 1 | CTD_human |
Hgene | FGF2 | C0017638 | Glioma | 1 | CTD_human |
Hgene | FGF2 | C0017639 | Gliosis | 1 | CTD_human |
Hgene | FGF2 | C0018800 | Cardiomegaly | 1 | CTD_human |
Hgene | FGF2 | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
Hgene | FGF2 | C0021368 | Inflammation | 1 | CTD_human |
Hgene | FGF2 | C0022333 | Jacksonian Seizure | 1 | CTD_human |
Hgene | FGF2 | C0022658 | Kidney Diseases | 1 | CTD_human |
Hgene | FGF2 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Hgene | FGF2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | FGF2 | C0025193 | Melancholia | 1 | CTD_human |
Hgene | FGF2 | C0025500 | Mesothelioma | 1 | CTD_human |
Hgene | FGF2 | C0027719 | Nephrosclerosis | 1 | CTD_human |
Hgene | FGF2 | C0027726 | Nephrotic Syndrome | 1 | CTD_human |
Hgene | FGF2 | C0027746 | Nerve Degeneration | 1 | CTD_human |
Hgene | FGF2 | C0029172 | Oral Submucous Fibrosis | 1 | CTD_human |
Hgene | FGF2 | C0031030 | Periapical Periodontitis | 1 | CTD_human |
Hgene | FGF2 | C0033054 | Prenatal Exposure Delayed Effects | 1 | CTD_human |
Hgene | FGF2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | FGF2 | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
Hgene | FGF2 | C0035126 | Reperfusion Injury | 1 | CTD_human |
Hgene | FGF2 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | FGF2 | C0036572 | Seizures | 1 | CTD_human |
Hgene | FGF2 | C0040028 | Thrombocythemia, Essential | 1 | CTD_human |
Hgene | FGF2 | C0041696 | Unipolar Depression | 1 | CTD_human |
Hgene | FGF2 | C0085109 | Corneal Neovascularization | 1 | CTD_human |
Hgene | FGF2 | C0085207 | Gestational Diabetes | 1 | CTD_human |
Hgene | FGF2 | C0086133 | Depressive Syndrome | 1 | CTD_human |
Hgene | FGF2 | C0149958 | Complex partial seizures | 1 | CTD_human |
Hgene | FGF2 | C0234533 | Generalized seizures | 1 | CTD_human |
Hgene | FGF2 | C0234535 | Clonic Seizures | 1 | CTD_human |
Hgene | FGF2 | C0235874 | Disease Exacerbation | 1 | CTD_human |
Hgene | FGF2 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
Hgene | FGF2 | C0239946 | Fibrosis, Liver | 1 | CTD_human |
Hgene | FGF2 | C0259783 | mixed gliomas | 1 | CTD_human |
Hgene | FGF2 | C0270824 | Visual seizure | 1 | CTD_human |
Hgene | FGF2 | C0270844 | Tonic Seizures | 1 | CTD_human |
Hgene | FGF2 | C0270846 | Epileptic drop attack | 1 | CTD_human |
Hgene | FGF2 | C0282126 | Depression, Neurotic | 1 | CTD_human |
Hgene | FGF2 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
Hgene | FGF2 | C0393953 | Anterior Cerebral Circulation Infarction | 1 | CTD_human |
Hgene | FGF2 | C0422850 | Seizures, Somatosensory | 1 | CTD_human |
Hgene | FGF2 | C0422852 | Seizures, Auditory | 1 | CTD_human |
Hgene | FGF2 | C0422853 | Olfactory seizure | 1 | CTD_human |
Hgene | FGF2 | C0422854 | Gustatory seizure | 1 | CTD_human |
Hgene | FGF2 | C0422855 | Vertiginous seizure | 1 | CTD_human |
Hgene | FGF2 | C0494475 | Tonic - clonic seizures | 1 | CTD_human |
Hgene | FGF2 | C0524686 | Periodontitis, Acute Nonsuppurative | 1 | CTD_human |
Hgene | FGF2 | C0555198 | Malignant Glioma | 1 | CTD_human |
Hgene | FGF2 | C0600427 | Cocaine Dependence | 1 | CTD_human |
Hgene | FGF2 | C0751056 | Non-epileptic convulsion | 1 | CTD_human |
Hgene | FGF2 | C0751110 | Single Seizure | 1 | CTD_human |
Hgene | FGF2 | C0751117 | Cryptogenic Tonic-Clonic Epilepsy | 1 | CTD_human |
Hgene | FGF2 | C0751118 | Epilepsy, Tonic-Clonic, Familial | 1 | CTD_human |
Hgene | FGF2 | C0751119 | Epilepsy, Tonic-Clonic, Symptomatic | 1 | CTD_human |
Hgene | FGF2 | C0751123 | Atonic Absence Seizures | 1 | CTD_human |
Hgene | FGF2 | C0751494 | Convulsive Seizures | 1 | CTD_human |
Hgene | FGF2 | C0751495 | Seizures, Focal | 1 | CTD_human |
Hgene | FGF2 | C0751496 | Seizures, Sensory | 1 | CTD_human |
Hgene | FGF2 | C0751952 | Anterior Circulation Brain Infarction | 1 | CTD_human |
Hgene | FGF2 | C0751953 | Brain Infarction, Posterior Circulation | 1 | CTD_human |
Hgene | FGF2 | C0751954 | Venous Infarction, Brain | 1 | CTD_human |
Hgene | FGF2 | C0751955 | Brain Infarction | 1 | CTD_human |
Hgene | FGF2 | C1383860 | Cardiac Hypertrophy | 1 | CTD_human |
Hgene | FGF2 | C1837218 | Cleft palate, isolated | 1 | CTD_human |
Hgene | FGF2 | C3489628 | Thrombocytosis, Autosomal Dominant | 1 | CTD_human |
Hgene | FGF2 | C3495874 | Nonepileptic Seizures | 1 | CTD_human |
Hgene | FGF2 | C3887640 | Astrocytosis | 1 | CTD_human |
Hgene | FGF2 | C4048158 | Convulsions | 1 | CTD_human |
Hgene | FGF2 | C4316903 | Absence Seizures | 1 | CTD_human |
Hgene | FGF2 | C4317109 | Epileptic Seizures | 1 | CTD_human |
Hgene | FGF2 | C4317123 | Myoclonic Seizures | 1 | CTD_human |
Hgene | FGF2 | C4505436 | Generalized Absence Seizures | 1 | CTD_human |
Hgene | FGF2 | C4721507 | Alveolitis, Fibrosing | 1 | CTD_human |
Tgene | C4014738 | MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2 | 4 | GENOMICS_ENGLAND;UNIPROT | |
Tgene | C4012727 | MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 1 | 2 | GENOMICS_ENGLAND | |
Tgene | C0152427 | Polydactyly | 1 | GENOMICS_ENGLAND | |
Tgene | C0431380 | Cortical Dysplasia | 1 | CTD_human | |
Tgene | C0431391 | Hemimegalencephaly | 1 | ORPHANET | |
Tgene | C1863924 | Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome | 1 | CTD_human;ORPHANET | |
Tgene | C1955869 | Malformations of Cortical Development | 1 | CTD_human |