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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FGF12-SYN3 (FusionGDB2 ID:HG2257TG8224)

Fusion Gene Summary for FGF12-SYN3

check button Fusion gene summary
Fusion gene informationFusion gene name: FGF12-SYN3
Fusion gene ID: hg2257tg8224
HgeneTgene
Gene symbol

FGF12

SYN3

Gene ID

2257

8224

Gene namefibroblast growth factor 12synapsin III
SynonymsEIEE47|FGF12B|FHF1-
Cytomap('FGF12')('SYN3')

3q28-q29

22q12.3

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor 12fibroblast growth factor 12Bfibroblast growth factor FGF-12bfibroblast growth factor homologous factor 1myocyte-activating factorsynapsin-3cN28H9.2 (synapsin III)
Modification date2020031520200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264730, ENST00000430714, 
ENST00000445105, ENST00000450716, 
ENST00000454309, ENST00000466144, 
Fusion gene scores* DoF score10 X 7 X 4=28015 X 15 X 4=900
# samples 1015
** MAII scorelog2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/900*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGF12 [Title/Abstract] AND SYN3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFGF12(192053150)-SYN3(32992722), # samples:3
Anticipated loss of major functional domain due to fusion event.FGF12-SYN3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FGF12-SYN3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FGF12-SYN3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FGF12-SYN3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FGF12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SYN3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A0TP-01AFGF12chr3

192053150

-SYN3chr22

32992722

-


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Fusion Gene ORF analysis for FGF12-SYN3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264730ENST00000467095FGF12chr3

192053150

-SYN3chr22

32992722

-
5CDS-intronENST00000430714ENST00000467095FGF12chr3

192053150

-SYN3chr22

32992722

-
5CDS-intronENST00000445105ENST00000467095FGF12chr3

192053150

-SYN3chr22

32992722

-
5CDS-intronENST00000450716ENST00000467095FGF12chr3

192053150

-SYN3chr22

32992722

-
5CDS-intronENST00000454309ENST00000467095FGF12chr3

192053150

-SYN3chr22

32992722

-
Frame-shiftENST00000430714ENST00000332840FGF12chr3

192053150

-SYN3chr22

32992722

-
Frame-shiftENST00000430714ENST00000358763FGF12chr3

192053150

-SYN3chr22

32992722

-
Frame-shiftENST00000445105ENST00000332840FGF12chr3

192053150

-SYN3chr22

32992722

-
Frame-shiftENST00000445105ENST00000358763FGF12chr3

192053150

-SYN3chr22

32992722

-
In-frameENST00000264730ENST00000332840FGF12chr3

192053150

-SYN3chr22

32992722

-
In-frameENST00000264730ENST00000358763FGF12chr3

192053150

-SYN3chr22

32992722

-
In-frameENST00000450716ENST00000332840FGF12chr3

192053150

-SYN3chr22

32992722

-
In-frameENST00000450716ENST00000358763FGF12chr3

192053150

-SYN3chr22

32992722

-
In-frameENST00000454309ENST00000332840FGF12chr3

192053150

-SYN3chr22

32992722

-
In-frameENST00000454309ENST00000358763FGF12chr3

192053150

-SYN3chr22

32992722

-
intron-3CDSENST00000466144ENST00000332840FGF12chr3

192053150

-SYN3chr22

32992722

-
intron-3CDSENST00000466144ENST00000358763FGF12chr3

192053150

-SYN3chr22

32992722

-
intron-intronENST00000466144ENST00000467095FGF12chr3

192053150

-SYN3chr22

32992722

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264730FGF12chr3192053150-ENST00000358763SYN3chr2232992722-240022801259419
ENST00000264730FGF12chr3192053150-ENST00000332840SYN3chr2232992722-239722801259419
ENST00000454309FGF12chr3192053150-ENST00000358763SYN3chr2232992722-341212408262271481
ENST00000454309FGF12chr3192053150-ENST00000332840SYN3chr2232992722-340912408262271481
ENST00000450716FGF12chr3192053150-ENST00000358763SYN3chr2232992722-25914191911450419
ENST00000450716FGF12chr3192053150-ENST00000332840SYN3chr2232992722-25884191911450419

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264730ENST00000358763FGF12chr3192053150-SYN3chr2232992722-0.0051467340.9948533
ENST00000264730ENST00000332840FGF12chr3192053150-SYN3chr2232992722-0.0051262190.9948738
ENST00000454309ENST00000358763FGF12chr3192053150-SYN3chr2232992722-0.01022490.98977506
ENST00000454309ENST00000332840FGF12chr3192053150-SYN3chr2232992722-0.0102544030.9897456
ENST00000450716ENST00000358763FGF12chr3192053150-SYN3chr2232992722-0.0057580620.9942419
ENST00000450716ENST00000332840FGF12chr3192053150-SYN3chr2232992722-0.0057570030.99424297

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Fusion Genomic Features for FGF12-SYN3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FGF12-SYN3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:192053150/chr22:32992722)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGF12chr3:192053150chr22:32992722ENST00000264730-3511_3876182.0MotifBipartite nuclear localization signal
HgeneFGF12chr3:192053150chr22:32992722ENST00000445105-4611_3876182.0MotifBipartite nuclear localization signal
HgeneFGF12chr3:192053150chr22:32992722ENST00000450716-4611_3876182.0MotifBipartite nuclear localization signal
HgeneFGF12chr3:192053150chr22:32992722ENST00000454309-3511_38138244.0MotifBipartite nuclear localization signal
TgeneSYN3chr3:192053150chr22:32992722ENST00000332840413400_531237581.0RegionNote=J%3B Pro-rich linker
TgeneSYN3chr3:192053150chr22:32992722ENST00000332840413532_580237581.0RegionNote=E
TgeneSYN3chr3:192053150chr22:32992722ENST00000358763514400_531237581.0RegionNote=J%3B Pro-rich linker
TgeneSYN3chr3:192053150chr22:32992722ENST00000358763514532_580237581.0RegionNote=E

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSYN3chr3:192053150chr22:32992722ENST000003328404131_28237581.0RegionNote=A
TgeneSYN3chr3:192053150chr22:32992722ENST0000033284041328_90237581.0RegionNote=B%3B linker
TgeneSYN3chr3:192053150chr22:32992722ENST0000033284041391_399237581.0RegionNote=C%3B actin-binding and synaptic-vesicle binding
TgeneSYN3chr3:192053150chr22:32992722ENST000003587635141_28237581.0RegionNote=A
TgeneSYN3chr3:192053150chr22:32992722ENST0000035876351428_90237581.0RegionNote=B%3B linker
TgeneSYN3chr3:192053150chr22:32992722ENST0000035876351491_399237581.0RegionNote=C%3B actin-binding and synaptic-vesicle binding


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Fusion Gene Sequence for FGF12-SYN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30206_30206_1_FGF12-SYN3_FGF12_chr3_192053150_ENST00000264730_SYN3_chr22_32992722_ENST00000332840_length(transcript)=2397nt_BP=228nt
ATGGAGAGCAAAGAACCCCAGCTCAAAGGGATTGTGACAAGGTTATTCAGCCAGCAGGGATACTTCCTGCAGATGCACCCAGATGGTACC
ATTGATGGGACCAAGGACGAAAACAGCGACTACACTCTCTTCAATCTAATTCCCGTGGGCCTGCGTGTAGTGGCCATCCAAGGAGTGAAG
GCTAGCCTCTATGTGGCCATGAATGGTGAAGGCTATCTCTACAGTTCAGTCACAGCCCCACACTTCCCGGTGGTAGTCAAGCTGGGACAT
GCCCACGCTGGAATGGGAAAGATCAAAGTGGAAAACCAGCTTGACTTCCAGGACATCACCAGCGTGGTCGCCATGGCCAAAACCTACGCC
ACCACCGAGGCCTTCATCGACTCCAAGTACGACATCCGCATCCAGAAAATTGGATCCAACTACAAGGCTTACATGAGAACCTCCATCTCT
GGGAACTGGAAGGCCAACACAGGCTCTGCCATGCTGGAGCAGGTGGCCATGACAGAGAGGTACAGGCTGTGGGTGGACAGCTGCTCGGAA
ATGTTTGGCGGCCTGGACATCTGTGCCGTCAAGGCTGTCCACAGCAAGGATGGCAGAGATTACATCATCGAGGTAATGGACAGCTCAATG
CCGCTGATTGGAGAGCATGTGGAAGAGGACAGACAGCTGATGGCCGACCTTGTTGTCTCCAAAATGAGCCAGCTCCCGATGCCAGGAGGC
ACAGCGCCCTCCCCCCTCAGACCTTGGGCTCCACAGATTAAATCAGCGAAATCCCCAGGGCAAGCCCAGCTGGGGCCTCAGCTAGGCCAG
CCCCAGCCACGCCCACCTCCGCAAGGAGGCCCTCGCCAAGCTCAGTCTCCTCAGCCCCAGAGATCTGGAAGCCCCTCCCAACAGAGGCTC
TCCCCACAAGGCCAGCAGCCCCTGAGCCCCCAGTCCGGATCTCCACAGCAGCAAAGGTCACCAGGCTCTCCGCAGCTATCCCGGGCATCC
AGTGGCAGCTCCCCAAACCAGGCCTCCAAGCCAGGTGCCACCCTCGCCTCACAGCCCCGGCCCCCTGTGCAGGGCCGTAGTACCTCCCAG
CAGGGTGAAGAGTCCAAGAAGCCAGCACCACCCCATCCGCATCTCAACAAATCTCAGTCCCTGACTAACAGCCTCAGCACATCCGACACC
TCCCAGCGTGGGACCCCAAGTGAAGACGAGGCCAAGGCTGAAACCATCCGCAACCTGAGGAAGTCTTTTGCCAGCCTGTTCTCTGACTAA
CGCCATCCAGGCTGGGAGGGGAAGAGTGCTCTGCTACACTCGTCCCCCTCCTGCCTCATCTTCCTTCTCAGCCTTGGTTCCTGATGGGAA
CAGAATGGAGGGCCTGAGAACATACTTTCTAAATGCCTTTGACCCAGGAACCGATTATCTATATTTGTTCCCATTTTCCTTCACCGTGAC
ATTCCAGCATTGTCTGACTGTGAGGTGGGCCTTTGAGAGCCTCCAGGTTCCTCAAAACAGGCCTGAGCGATGGGCATCACACCCTCTGCC
TACCCACGTGCCTGCTTACCTGCCAGATAACCAAGTGAGATGTCTGCGAGTGGCTAGTTTTCACATTCTTACTAGTGTTTGGCTCACCTT
TGGGCAAAGGCCCCCTCTAGGCCTTGCCCCACCTCCATCAAACGCAGACACTGTAGTCAGACCTCAGCAATATAGGAGGCAATAATCTTT
TAACAGTGTTTTGCAAACAAACAAAAAGAGAAAAATCCCAGCCAGGGGAACTCGCCACCTGCCCACGCTAGTTCCATCCACGCTCAAGAC
CCGCCCTTAGACCAGGCAGGCAAAGGCCCCCATCACACTCGGCCACTAGTGGGGTCCTGAGGCCAAGAAAGAAACCAGACCCTGTATGAC
AAGTGGGGTCTTTCAGAACACGACAGAAACAGGGGGGCCCTTGTAATGCCACTCATACTCAGAGCATTATTCTTATTTGGACAGCCAAGG
GCAGATCACAGGTTATTGTAGGAATAAAGACTAGTTTACAAAGGAGAAAGAGGCCCTGGACTTCCCAAGGAAAGGGTCAGGTTAGGGCTC
CTGTACCCATTCTGTTCCACCACTGTTTGATCTCTCTGGCCTCCCACCAGGAATGCCGTTTCCTTTTTATGGATCTGTTGGGAACCAGAG
AGAATCAACAGATCAATGACATAGGATCCGAAGTGCAATGATAGTCACTTCTAGTTTGGCATTTCACAAACTCTGTACAGCAAGGTATTG
GTAGGTTACTCAATTTCAAAAGGGCCCCATGGCCAAATATGTTTAGGAACCGCTGTTTGTATTTCTTTTTTTGGAGACGCATTGTATATA

>30206_30206_1_FGF12-SYN3_FGF12_chr3_192053150_ENST00000264730_SYN3_chr22_32992722_ENST00000332840_length(amino acids)=419AA_BP=76
MESKEPQLKGIVTRLFSQQGYFLQMHPDGTIDGTKDENSDYTLFNLIPVGLRVVAIQGVKASLYVAMNGEGYLYSSVTAPHFPVVVKLGH
AHAGMGKIKVENQLDFQDITSVVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSE
MFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDRQLMADLVVSKMSQLPMPGGTAPSPLRPWAPQIKSAKSPGQAQLGPQLGQ
PQPRPPPQGGPRQAQSPQPQRSGSPSQQRLSPQGQQPLSPQSGSPQQQRSPGSPQLSRASSGSSPNQASKPGATLASQPRPPVQGRSTSQ

--------------------------------------------------------------
>30206_30206_2_FGF12-SYN3_FGF12_chr3_192053150_ENST00000264730_SYN3_chr22_32992722_ENST00000358763_length(transcript)=2400nt_BP=228nt
ATGGAGAGCAAAGAACCCCAGCTCAAAGGGATTGTGACAAGGTTATTCAGCCAGCAGGGATACTTCCTGCAGATGCACCCAGATGGTACC
ATTGATGGGACCAAGGACGAAAACAGCGACTACACTCTCTTCAATCTAATTCCCGTGGGCCTGCGTGTAGTGGCCATCCAAGGAGTGAAG
GCTAGCCTCTATGTGGCCATGAATGGTGAAGGCTATCTCTACAGTTCAGTCACAGCCCCACACTTCCCGGTGGTAGTCAAGCTGGGACAT
GCCCACGCTGGAATGGGAAAGATCAAAGTGGAAAACCAGCTTGACTTCCAGGACATCACCAGCGTGGTCGCCATGGCCAAAACCTACGCC
ACCACCGAGGCCTTCATCGACTCCAAGTACGACATCCGCATCCAGAAAATTGGATCCAACTACAAGGCTTACATGAGAACCTCCATCTCT
GGGAACTGGAAGGCCAACACAGGCTCTGCCATGCTGGAGCAGGTGGCCATGACAGAGAGGTACAGGCTGTGGGTGGACAGCTGCTCGGAA
ATGTTTGGCGGCCTGGACATCTGTGCCGTCAAGGCTGTCCACAGCAAGGATGGCAGAGATTACATCATCGAGGTAATGGACAGCTCAATG
CCGCTGATTGGAGAGCATGTGGAAGAGGACAGACAGCTGATGGCCGACCTTGTTGTCTCCAAAATGAGCCAGCTCCCGATGCCAGGAGGC
ACAGCGCCCTCCCCCCTCAGACCTTGGGCTCCACAGATTAAATCAGCGAAATCCCCAGGGCAAGCCCAGCTGGGGCCTCAGCTAGGCCAG
CCCCAGCCACGCCCACCTCCGCAAGGAGGCCCTCGCCAAGCTCAGTCTCCTCAGCCCCAGAGATCTGGAAGCCCCTCCCAACAGAGGCTC
TCCCCACAAGGCCAGCAGCCCCTGAGCCCCCAGTCCGGATCTCCACAGCAGCAAAGGTCACCAGGCTCTCCGCAGCTATCCCGGGCATCC
AGTGGCAGCTCCCCAAACCAGGCCTCCAAGCCAGGTGCCACCCTCGCCTCACAGCCCCGGCCCCCTGTGCAGGGCCGTAGTACCTCCCAG
CAGGGTGAAGAGTCCAAGAAGCCAGCACCACCCCATCCGCATCTCAACAAATCTCAGTCCCTGACTAACAGCCTCAGCACATCCGACACC
TCCCAGCGTGGGACCCCAAGTGAAGACGAGGCCAAGGCTGAAACCATCCGCAACCTGAGGAAGTCTTTTGCCAGCCTGTTCTCTGACTAA
CGCCATCCAGGCTGGGAGGGGAAGAGTGCTCTGCTACACTCGTCCCCCTCCTGCCTCATCTTCCTTCTCAGCCTTGGTTCCTGATGGGAA
CAGAATGGAGGGCCTGAGAACATACTTTCTAAATGCCTTTGACCCAGGAACCGATTATCTATATTTGTTCCCATTTTCCTTCACCGTGAC
ATTCCAGCATTGTCTGACTGTGAGGTGGGCCTTTGAGAGCCTCCAGGTTCCTCAAAACAGGCCTGAGCGATGGGCATCACACCCTCTGCC
TACCCACGTGCCTGCTTACCTGCCAGATAACCAAGTGAGATGTCTGCGAGTGGCTAGTTTTCACATTCTTACTAGTGTTTGGCTCACCTT
TGGGCAAAGGCCCCCTCTAGGCCTTGCCCCACCTCCATCAAACGCAGACACTGTAGTCAGACCTCAGCAATATAGGAGGCAATAATCTTT
TAACAGTGTTTTGCAAACAAACAAAAAGAGAAAAATCCCAGCCAGGGGAACTCGCCACCTGCCCACGCTAGTTCCATCCACGCTCAAGAC
CCGCCCTTAGACCAGGCAGGCAAAGGCCCCCATCACACTCGGCCACTAGTGGGGTCCTGAGGCCAAGAAAGAAACCAGACCCTGTATGAC
AAGTGGGGTCTTTCAGAACACGACAGAAACAGGGGGGCCCTTGTAATGCCACTCATACTCAGAGCATTATTCTTATTTGGACAGCCAAGG
GCAGATCACAGGTTATTGTAGGAATAAAGACTAGTTTACAAAGGAGAAAGAGGCCCTGGACTTCCCAAGGAAAGGGTCAGGTTAGGGCTC
CTGTACCCATTCTGTTCCACCACTGTTTGATCTCTCTGGCCTCCCACCAGGAATGCCGTTTCCTTTTTATGGATCTGTTGGGAACCAGAG
AGAATCAACAGATCAATGACATAGGATCCGAAGTGCAATGATAGTCACTTCTAGTTTGGCATTTCACAAACTCTGTACAGCAAGGTATTG
GTAGGTTACTCAATTTCAAAAGGGCCCCATGGCCAAATATGTTTAGGAACCGCTGTTTGTATTTCTTTTTTTGGAGACGCATTGTATATA

>30206_30206_2_FGF12-SYN3_FGF12_chr3_192053150_ENST00000264730_SYN3_chr22_32992722_ENST00000358763_length(amino acids)=419AA_BP=76
MESKEPQLKGIVTRLFSQQGYFLQMHPDGTIDGTKDENSDYTLFNLIPVGLRVVAIQGVKASLYVAMNGEGYLYSSVTAPHFPVVVKLGH
AHAGMGKIKVENQLDFQDITSVVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSE
MFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDRQLMADLVVSKMSQLPMPGGTAPSPLRPWAPQIKSAKSPGQAQLGPQLGQ
PQPRPPPQGGPRQAQSPQPQRSGSPSQQRLSPQGQQPLSPQSGSPQQQRSPGSPQLSRASSGSSPNQASKPGATLASQPRPPVQGRSTSQ

--------------------------------------------------------------
>30206_30206_3_FGF12-SYN3_FGF12_chr3_192053150_ENST00000450716_SYN3_chr22_32992722_ENST00000332840_length(transcript)=2588nt_BP=419nt
TTAAAGCAGGAGCCTTGAGAGCCTGATAAGCTGTTGACACAAGTGCTTTTGAGAATAGCAGGAAGCCTGAGGGGAAGGAAGGAAGTACGG
GCGAAATCATCAGATTGGCTTCCCAGATTTGGGAATCTGAAGCGGGCCCACATCTTCCGGCCAACTTCCATTGAACTTCCCAGCACTCGA
AAGGGACCGAAATGGAGAGCAAAGAACCCCAGCTCAAAGGGATTGTGACAAGGTTATTCAGCCAGCAGGGATACTTCCTGCAGATGCACC
CAGATGGTACCATTGATGGGACCAAGGACGAAAACAGCGACTACACTCTCTTCAATCTAATTCCCGTGGGCCTGCGTGTAGTGGCCATCC
AAGGAGTGAAGGCTAGCCTCTATGTGGCCATGAATGGTGAAGGCTATCTCTACAGTTCAGTCACAGCCCCACACTTCCCGGTGGTAGTCA
AGCTGGGACATGCCCACGCTGGAATGGGAAAGATCAAAGTGGAAAACCAGCTTGACTTCCAGGACATCACCAGCGTGGTCGCCATGGCCA
AAACCTACGCCACCACCGAGGCCTTCATCGACTCCAAGTACGACATCCGCATCCAGAAAATTGGATCCAACTACAAGGCTTACATGAGAA
CCTCCATCTCTGGGAACTGGAAGGCCAACACAGGCTCTGCCATGCTGGAGCAGGTGGCCATGACAGAGAGGTACAGGCTGTGGGTGGACA
GCTGCTCGGAAATGTTTGGCGGCCTGGACATCTGTGCCGTCAAGGCTGTCCACAGCAAGGATGGCAGAGATTACATCATCGAGGTAATGG
ACAGCTCAATGCCGCTGATTGGAGAGCATGTGGAAGAGGACAGACAGCTGATGGCCGACCTTGTTGTCTCCAAAATGAGCCAGCTCCCGA
TGCCAGGAGGCACAGCGCCCTCCCCCCTCAGACCTTGGGCTCCACAGATTAAATCAGCGAAATCCCCAGGGCAAGCCCAGCTGGGGCCTC
AGCTAGGCCAGCCCCAGCCACGCCCACCTCCGCAAGGAGGCCCTCGCCAAGCTCAGTCTCCTCAGCCCCAGAGATCTGGAAGCCCCTCCC
AACAGAGGCTCTCCCCACAAGGCCAGCAGCCCCTGAGCCCCCAGTCCGGATCTCCACAGCAGCAAAGGTCACCAGGCTCTCCGCAGCTAT
CCCGGGCATCCAGTGGCAGCTCCCCAAACCAGGCCTCCAAGCCAGGTGCCACCCTCGCCTCACAGCCCCGGCCCCCTGTGCAGGGCCGTA
GTACCTCCCAGCAGGGTGAAGAGTCCAAGAAGCCAGCACCACCCCATCCGCATCTCAACAAATCTCAGTCCCTGACTAACAGCCTCAGCA
CATCCGACACCTCCCAGCGTGGGACCCCAAGTGAAGACGAGGCCAAGGCTGAAACCATCCGCAACCTGAGGAAGTCTTTTGCCAGCCTGT
TCTCTGACTAACGCCATCCAGGCTGGGAGGGGAAGAGTGCTCTGCTACACTCGTCCCCCTCCTGCCTCATCTTCCTTCTCAGCCTTGGTT
CCTGATGGGAACAGAATGGAGGGCCTGAGAACATACTTTCTAAATGCCTTTGACCCAGGAACCGATTATCTATATTTGTTCCCATTTTCC
TTCACCGTGACATTCCAGCATTGTCTGACTGTGAGGTGGGCCTTTGAGAGCCTCCAGGTTCCTCAAAACAGGCCTGAGCGATGGGCATCA
CACCCTCTGCCTACCCACGTGCCTGCTTACCTGCCAGATAACCAAGTGAGATGTCTGCGAGTGGCTAGTTTTCACATTCTTACTAGTGTT
TGGCTCACCTTTGGGCAAAGGCCCCCTCTAGGCCTTGCCCCACCTCCATCAAACGCAGACACTGTAGTCAGACCTCAGCAATATAGGAGG
CAATAATCTTTTAACAGTGTTTTGCAAACAAACAAAAAGAGAAAAATCCCAGCCAGGGGAACTCGCCACCTGCCCACGCTAGTTCCATCC
ACGCTCAAGACCCGCCCTTAGACCAGGCAGGCAAAGGCCCCCATCACACTCGGCCACTAGTGGGGTCCTGAGGCCAAGAAAGAAACCAGA
CCCTGTATGACAAGTGGGGTCTTTCAGAACACGACAGAAACAGGGGGGCCCTTGTAATGCCACTCATACTCAGAGCATTATTCTTATTTG
GACAGCCAAGGGCAGATCACAGGTTATTGTAGGAATAAAGACTAGTTTACAAAGGAGAAAGAGGCCCTGGACTTCCCAAGGAAAGGGTCA
GGTTAGGGCTCCTGTACCCATTCTGTTCCACCACTGTTTGATCTCTCTGGCCTCCCACCAGGAATGCCGTTTCCTTTTTATGGATCTGTT
GGGAACCAGAGAGAATCAACAGATCAATGACATAGGATCCGAAGTGCAATGATAGTCACTTCTAGTTTGGCATTTCACAAACTCTGTACA
GCAAGGTATTGGTAGGTTACTCAATTTCAAAAGGGCCCCATGGCCAAATATGTTTAGGAACCGCTGTTTGTATTTCTTTTTTTGGAGACG

>30206_30206_3_FGF12-SYN3_FGF12_chr3_192053150_ENST00000450716_SYN3_chr22_32992722_ENST00000332840_length(amino acids)=419AA_BP=76
MESKEPQLKGIVTRLFSQQGYFLQMHPDGTIDGTKDENSDYTLFNLIPVGLRVVAIQGVKASLYVAMNGEGYLYSSVTAPHFPVVVKLGH
AHAGMGKIKVENQLDFQDITSVVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSE
MFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDRQLMADLVVSKMSQLPMPGGTAPSPLRPWAPQIKSAKSPGQAQLGPQLGQ
PQPRPPPQGGPRQAQSPQPQRSGSPSQQRLSPQGQQPLSPQSGSPQQQRSPGSPQLSRASSGSSPNQASKPGATLASQPRPPVQGRSTSQ

--------------------------------------------------------------
>30206_30206_4_FGF12-SYN3_FGF12_chr3_192053150_ENST00000450716_SYN3_chr22_32992722_ENST00000358763_length(transcript)=2591nt_BP=419nt
TTAAAGCAGGAGCCTTGAGAGCCTGATAAGCTGTTGACACAAGTGCTTTTGAGAATAGCAGGAAGCCTGAGGGGAAGGAAGGAAGTACGG
GCGAAATCATCAGATTGGCTTCCCAGATTTGGGAATCTGAAGCGGGCCCACATCTTCCGGCCAACTTCCATTGAACTTCCCAGCACTCGA
AAGGGACCGAAATGGAGAGCAAAGAACCCCAGCTCAAAGGGATTGTGACAAGGTTATTCAGCCAGCAGGGATACTTCCTGCAGATGCACC
CAGATGGTACCATTGATGGGACCAAGGACGAAAACAGCGACTACACTCTCTTCAATCTAATTCCCGTGGGCCTGCGTGTAGTGGCCATCC
AAGGAGTGAAGGCTAGCCTCTATGTGGCCATGAATGGTGAAGGCTATCTCTACAGTTCAGTCACAGCCCCACACTTCCCGGTGGTAGTCA
AGCTGGGACATGCCCACGCTGGAATGGGAAAGATCAAAGTGGAAAACCAGCTTGACTTCCAGGACATCACCAGCGTGGTCGCCATGGCCA
AAACCTACGCCACCACCGAGGCCTTCATCGACTCCAAGTACGACATCCGCATCCAGAAAATTGGATCCAACTACAAGGCTTACATGAGAA
CCTCCATCTCTGGGAACTGGAAGGCCAACACAGGCTCTGCCATGCTGGAGCAGGTGGCCATGACAGAGAGGTACAGGCTGTGGGTGGACA
GCTGCTCGGAAATGTTTGGCGGCCTGGACATCTGTGCCGTCAAGGCTGTCCACAGCAAGGATGGCAGAGATTACATCATCGAGGTAATGG
ACAGCTCAATGCCGCTGATTGGAGAGCATGTGGAAGAGGACAGACAGCTGATGGCCGACCTTGTTGTCTCCAAAATGAGCCAGCTCCCGA
TGCCAGGAGGCACAGCGCCCTCCCCCCTCAGACCTTGGGCTCCACAGATTAAATCAGCGAAATCCCCAGGGCAAGCCCAGCTGGGGCCTC
AGCTAGGCCAGCCCCAGCCACGCCCACCTCCGCAAGGAGGCCCTCGCCAAGCTCAGTCTCCTCAGCCCCAGAGATCTGGAAGCCCCTCCC
AACAGAGGCTCTCCCCACAAGGCCAGCAGCCCCTGAGCCCCCAGTCCGGATCTCCACAGCAGCAAAGGTCACCAGGCTCTCCGCAGCTAT
CCCGGGCATCCAGTGGCAGCTCCCCAAACCAGGCCTCCAAGCCAGGTGCCACCCTCGCCTCACAGCCCCGGCCCCCTGTGCAGGGCCGTA
GTACCTCCCAGCAGGGTGAAGAGTCCAAGAAGCCAGCACCACCCCATCCGCATCTCAACAAATCTCAGTCCCTGACTAACAGCCTCAGCA
CATCCGACACCTCCCAGCGTGGGACCCCAAGTGAAGACGAGGCCAAGGCTGAAACCATCCGCAACCTGAGGAAGTCTTTTGCCAGCCTGT
TCTCTGACTAACGCCATCCAGGCTGGGAGGGGAAGAGTGCTCTGCTACACTCGTCCCCCTCCTGCCTCATCTTCCTTCTCAGCCTTGGTT
CCTGATGGGAACAGAATGGAGGGCCTGAGAACATACTTTCTAAATGCCTTTGACCCAGGAACCGATTATCTATATTTGTTCCCATTTTCC
TTCACCGTGACATTCCAGCATTGTCTGACTGTGAGGTGGGCCTTTGAGAGCCTCCAGGTTCCTCAAAACAGGCCTGAGCGATGGGCATCA
CACCCTCTGCCTACCCACGTGCCTGCTTACCTGCCAGATAACCAAGTGAGATGTCTGCGAGTGGCTAGTTTTCACATTCTTACTAGTGTT
TGGCTCACCTTTGGGCAAAGGCCCCCTCTAGGCCTTGCCCCACCTCCATCAAACGCAGACACTGTAGTCAGACCTCAGCAATATAGGAGG
CAATAATCTTTTAACAGTGTTTTGCAAACAAACAAAAAGAGAAAAATCCCAGCCAGGGGAACTCGCCACCTGCCCACGCTAGTTCCATCC
ACGCTCAAGACCCGCCCTTAGACCAGGCAGGCAAAGGCCCCCATCACACTCGGCCACTAGTGGGGTCCTGAGGCCAAGAAAGAAACCAGA
CCCTGTATGACAAGTGGGGTCTTTCAGAACACGACAGAAACAGGGGGGCCCTTGTAATGCCACTCATACTCAGAGCATTATTCTTATTTG
GACAGCCAAGGGCAGATCACAGGTTATTGTAGGAATAAAGACTAGTTTACAAAGGAGAAAGAGGCCCTGGACTTCCCAAGGAAAGGGTCA
GGTTAGGGCTCCTGTACCCATTCTGTTCCACCACTGTTTGATCTCTCTGGCCTCCCACCAGGAATGCCGTTTCCTTTTTATGGATCTGTT
GGGAACCAGAGAGAATCAACAGATCAATGACATAGGATCCGAAGTGCAATGATAGTCACTTCTAGTTTGGCATTTCACAAACTCTGTACA
GCAAGGTATTGGTAGGTTACTCAATTTCAAAAGGGCCCCATGGCCAAATATGTTTAGGAACCGCTGTTTGTATTTCTTTTTTTGGAGACG

>30206_30206_4_FGF12-SYN3_FGF12_chr3_192053150_ENST00000450716_SYN3_chr22_32992722_ENST00000358763_length(amino acids)=419AA_BP=76
MESKEPQLKGIVTRLFSQQGYFLQMHPDGTIDGTKDENSDYTLFNLIPVGLRVVAIQGVKASLYVAMNGEGYLYSSVTAPHFPVVVKLGH
AHAGMGKIKVENQLDFQDITSVVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSE
MFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDRQLMADLVVSKMSQLPMPGGTAPSPLRPWAPQIKSAKSPGQAQLGPQLGQ
PQPRPPPQGGPRQAQSPQPQRSGSPSQQRLSPQGQQPLSPQSGSPQQQRSPGSPQLSRASSGSSPNQASKPGATLASQPRPPVQGRSTSQ

--------------------------------------------------------------
>30206_30206_5_FGF12-SYN3_FGF12_chr3_192053150_ENST00000454309_SYN3_chr22_32992722_ENST00000332840_length(transcript)=3409nt_BP=1240nt
AGTGCTGCTGGCCGGGAGTTGCTCTCACCGCAGCTGGAAACAGCTGCCCCCGCCCCGCGCCCCTACCCAGACTCCGGGTAACCGCTCCCA
CTTCGCGCCTCTCGGAATTCCAGAACTCGGGTGGCCGGCCCCTGGAAAGCCGCAGCCGGCGCGATGCATTCTGTAGACCTCACCCTGCTG
GGACGGACCTCCTAATCTTCAGAACCGCGGGCCGCAGGGAGTTAAATTGCTGCCTTCCTCTCCTTCTCTCGTGCGGTTGGTGGCTTGTTT
TCTAAAGGAACGTTTTATTCACTTTTTAGTATTTTCTACCGGGGGCGCGCTACCCGCCTGGGTCCAGACTCTGCTTTGTAAACGGGTTTT
CTATGTATGTATGTGTAGGTATACTTTGGACACCTTACAACGCTTGCGCCTCTCCAACAGAGGCACGTCTTGTTATTTTGGGCATCGTTC
TTCCCCTTCCACTTGGTACCCCGAACGCAGTGTGACTAAACTCCCCACTGCCCCTTGGACGCCGATCGCCTTGGGGTGCAAGTTTGGGGT
GCAAACGTCTACTTCGCAAGAGGGCCTGGGACCGCCCCGCCCCGCCCCCCGGCCGCCAGAGGTTGGGGAAGTTTACATCTGGATTTTCAC
ACATTTTGTCGCCACTGCCCAGACTTTGACTAACCTTGTGAGCGCCGGGTTTTCGATACTGCAGCCTCCTCAAATTTTAGCACTGCCTCC
CCGCGACTGCCCTTTCCCTGGCCGCCCAGGTCCTGCCCTCGCCCCGGCGGAGCGCAAGCCGGAGGGCGCAGTAGAGGCTGGGGCCTGAGG
CCCTCGCTGAGCAGCTATGGCTGCGGCGATAGCCAGCTCCTTGATCCGGCAGAAGCGGCAGGCGAGGGAGTCCAACAGCGACCGAGTGTC
GGCCTCCAAGCGCCGCTCCAGCCCCAGCAAAGACGGGCGCTCCCTGTGCGAGAGGCACGTCCTCGGGGTGTTCAGCAAAGTGCGCTTCTG
CAGCGGCCGCAAGAGGCCGGTGAGGCGGAGACCAGAACCCCAGCTCAAAGGGATTGTGACAAGGTTATTCAGCCAGCAGGGATACTTCCT
GCAGATGCACCCAGATGGTACCATTGATGGGACCAAGGACGAAAACAGCGACTACACTCTCTTCAATCTAATTCCCGTGGGCCTGCGTGT
AGTGGCCATCCAAGGAGTGAAGGCTAGCCTCTATGTGGCCATGAATGGTGAAGGCTATCTCTACAGTTCAGTCACAGCCCCACACTTCCC
GGTGGTAGTCAAGCTGGGACATGCCCACGCTGGAATGGGAAAGATCAAAGTGGAAAACCAGCTTGACTTCCAGGACATCACCAGCGTGGT
CGCCATGGCCAAAACCTACGCCACCACCGAGGCCTTCATCGACTCCAAGTACGACATCCGCATCCAGAAAATTGGATCCAACTACAAGGC
TTACATGAGAACCTCCATCTCTGGGAACTGGAAGGCCAACACAGGCTCTGCCATGCTGGAGCAGGTGGCCATGACAGAGAGGTACAGGCT
GTGGGTGGACAGCTGCTCGGAAATGTTTGGCGGCCTGGACATCTGTGCCGTCAAGGCTGTCCACAGCAAGGATGGCAGAGATTACATCAT
CGAGGTAATGGACAGCTCAATGCCGCTGATTGGAGAGCATGTGGAAGAGGACAGACAGCTGATGGCCGACCTTGTTGTCTCCAAAATGAG
CCAGCTCCCGATGCCAGGAGGCACAGCGCCCTCCCCCCTCAGACCTTGGGCTCCACAGATTAAATCAGCGAAATCCCCAGGGCAAGCCCA
GCTGGGGCCTCAGCTAGGCCAGCCCCAGCCACGCCCACCTCCGCAAGGAGGCCCTCGCCAAGCTCAGTCTCCTCAGCCCCAGAGATCTGG
AAGCCCCTCCCAACAGAGGCTCTCCCCACAAGGCCAGCAGCCCCTGAGCCCCCAGTCCGGATCTCCACAGCAGCAAAGGTCACCAGGCTC
TCCGCAGCTATCCCGGGCATCCAGTGGCAGCTCCCCAAACCAGGCCTCCAAGCCAGGTGCCACCCTCGCCTCACAGCCCCGGCCCCCTGT
GCAGGGCCGTAGTACCTCCCAGCAGGGTGAAGAGTCCAAGAAGCCAGCACCACCCCATCCGCATCTCAACAAATCTCAGTCCCTGACTAA
CAGCCTCAGCACATCCGACACCTCCCAGCGTGGGACCCCAAGTGAAGACGAGGCCAAGGCTGAAACCATCCGCAACCTGAGGAAGTCTTT
TGCCAGCCTGTTCTCTGACTAACGCCATCCAGGCTGGGAGGGGAAGAGTGCTCTGCTACACTCGTCCCCCTCCTGCCTCATCTTCCTTCT
CAGCCTTGGTTCCTGATGGGAACAGAATGGAGGGCCTGAGAACATACTTTCTAAATGCCTTTGACCCAGGAACCGATTATCTATATTTGT
TCCCATTTTCCTTCACCGTGACATTCCAGCATTGTCTGACTGTGAGGTGGGCCTTTGAGAGCCTCCAGGTTCCTCAAAACAGGCCTGAGC
GATGGGCATCACACCCTCTGCCTACCCACGTGCCTGCTTACCTGCCAGATAACCAAGTGAGATGTCTGCGAGTGGCTAGTTTTCACATTC
TTACTAGTGTTTGGCTCACCTTTGGGCAAAGGCCCCCTCTAGGCCTTGCCCCACCTCCATCAAACGCAGACACTGTAGTCAGACCTCAGC
AATATAGGAGGCAATAATCTTTTAACAGTGTTTTGCAAACAAACAAAAAGAGAAAAATCCCAGCCAGGGGAACTCGCCACCTGCCCACGC
TAGTTCCATCCACGCTCAAGACCCGCCCTTAGACCAGGCAGGCAAAGGCCCCCATCACACTCGGCCACTAGTGGGGTCCTGAGGCCAAGA
AAGAAACCAGACCCTGTATGACAAGTGGGGTCTTTCAGAACACGACAGAAACAGGGGGGCCCTTGTAATGCCACTCATACTCAGAGCATT
ATTCTTATTTGGACAGCCAAGGGCAGATCACAGGTTATTGTAGGAATAAAGACTAGTTTACAAAGGAGAAAGAGGCCCTGGACTTCCCAA
GGAAAGGGTCAGGTTAGGGCTCCTGTACCCATTCTGTTCCACCACTGTTTGATCTCTCTGGCCTCCCACCAGGAATGCCGTTTCCTTTTT
ATGGATCTGTTGGGAACCAGAGAGAATCAACAGATCAATGACATAGGATCCGAAGTGCAATGATAGTCACTTCTAGTTTGGCATTTCACA
AACTCTGTACAGCAAGGTATTGGTAGGTTACTCAATTTCAAAAGGGCCCCATGGCCAAATATGTTTAGGAACCGCTGTTTGTATTTCTTT

>30206_30206_5_FGF12-SYN3_FGF12_chr3_192053150_ENST00000454309_SYN3_chr22_32992722_ENST00000332840_length(amino acids)=481AA_BP=138
MAAAIASSLIRQKRQARESNSDRVSASKRRSSPSKDGRSLCERHVLGVFSKVRFCSGRKRPVRRRPEPQLKGIVTRLFSQQGYFLQMHPD
GTIDGTKDENSDYTLFNLIPVGLRVVAIQGVKASLYVAMNGEGYLYSSVTAPHFPVVVKLGHAHAGMGKIKVENQLDFQDITSVVAMAKT
YATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDS
SMPLIGEHVEEDRQLMADLVVSKMSQLPMPGGTAPSPLRPWAPQIKSAKSPGQAQLGPQLGQPQPRPPPQGGPRQAQSPQPQRSGSPSQQ
RLSPQGQQPLSPQSGSPQQQRSPGSPQLSRASSGSSPNQASKPGATLASQPRPPVQGRSTSQQGEESKKPAPPHPHLNKSQSLTNSLSTS

--------------------------------------------------------------
>30206_30206_6_FGF12-SYN3_FGF12_chr3_192053150_ENST00000454309_SYN3_chr22_32992722_ENST00000358763_length(transcript)=3412nt_BP=1240nt
AGTGCTGCTGGCCGGGAGTTGCTCTCACCGCAGCTGGAAACAGCTGCCCCCGCCCCGCGCCCCTACCCAGACTCCGGGTAACCGCTCCCA
CTTCGCGCCTCTCGGAATTCCAGAACTCGGGTGGCCGGCCCCTGGAAAGCCGCAGCCGGCGCGATGCATTCTGTAGACCTCACCCTGCTG
GGACGGACCTCCTAATCTTCAGAACCGCGGGCCGCAGGGAGTTAAATTGCTGCCTTCCTCTCCTTCTCTCGTGCGGTTGGTGGCTTGTTT
TCTAAAGGAACGTTTTATTCACTTTTTAGTATTTTCTACCGGGGGCGCGCTACCCGCCTGGGTCCAGACTCTGCTTTGTAAACGGGTTTT
CTATGTATGTATGTGTAGGTATACTTTGGACACCTTACAACGCTTGCGCCTCTCCAACAGAGGCACGTCTTGTTATTTTGGGCATCGTTC
TTCCCCTTCCACTTGGTACCCCGAACGCAGTGTGACTAAACTCCCCACTGCCCCTTGGACGCCGATCGCCTTGGGGTGCAAGTTTGGGGT
GCAAACGTCTACTTCGCAAGAGGGCCTGGGACCGCCCCGCCCCGCCCCCCGGCCGCCAGAGGTTGGGGAAGTTTACATCTGGATTTTCAC
ACATTTTGTCGCCACTGCCCAGACTTTGACTAACCTTGTGAGCGCCGGGTTTTCGATACTGCAGCCTCCTCAAATTTTAGCACTGCCTCC
CCGCGACTGCCCTTTCCCTGGCCGCCCAGGTCCTGCCCTCGCCCCGGCGGAGCGCAAGCCGGAGGGCGCAGTAGAGGCTGGGGCCTGAGG
CCCTCGCTGAGCAGCTATGGCTGCGGCGATAGCCAGCTCCTTGATCCGGCAGAAGCGGCAGGCGAGGGAGTCCAACAGCGACCGAGTGTC
GGCCTCCAAGCGCCGCTCCAGCCCCAGCAAAGACGGGCGCTCCCTGTGCGAGAGGCACGTCCTCGGGGTGTTCAGCAAAGTGCGCTTCTG
CAGCGGCCGCAAGAGGCCGGTGAGGCGGAGACCAGAACCCCAGCTCAAAGGGATTGTGACAAGGTTATTCAGCCAGCAGGGATACTTCCT
GCAGATGCACCCAGATGGTACCATTGATGGGACCAAGGACGAAAACAGCGACTACACTCTCTTCAATCTAATTCCCGTGGGCCTGCGTGT
AGTGGCCATCCAAGGAGTGAAGGCTAGCCTCTATGTGGCCATGAATGGTGAAGGCTATCTCTACAGTTCAGTCACAGCCCCACACTTCCC
GGTGGTAGTCAAGCTGGGACATGCCCACGCTGGAATGGGAAAGATCAAAGTGGAAAACCAGCTTGACTTCCAGGACATCACCAGCGTGGT
CGCCATGGCCAAAACCTACGCCACCACCGAGGCCTTCATCGACTCCAAGTACGACATCCGCATCCAGAAAATTGGATCCAACTACAAGGC
TTACATGAGAACCTCCATCTCTGGGAACTGGAAGGCCAACACAGGCTCTGCCATGCTGGAGCAGGTGGCCATGACAGAGAGGTACAGGCT
GTGGGTGGACAGCTGCTCGGAAATGTTTGGCGGCCTGGACATCTGTGCCGTCAAGGCTGTCCACAGCAAGGATGGCAGAGATTACATCAT
CGAGGTAATGGACAGCTCAATGCCGCTGATTGGAGAGCATGTGGAAGAGGACAGACAGCTGATGGCCGACCTTGTTGTCTCCAAAATGAG
CCAGCTCCCGATGCCAGGAGGCACAGCGCCCTCCCCCCTCAGACCTTGGGCTCCACAGATTAAATCAGCGAAATCCCCAGGGCAAGCCCA
GCTGGGGCCTCAGCTAGGCCAGCCCCAGCCACGCCCACCTCCGCAAGGAGGCCCTCGCCAAGCTCAGTCTCCTCAGCCCCAGAGATCTGG
AAGCCCCTCCCAACAGAGGCTCTCCCCACAAGGCCAGCAGCCCCTGAGCCCCCAGTCCGGATCTCCACAGCAGCAAAGGTCACCAGGCTC
TCCGCAGCTATCCCGGGCATCCAGTGGCAGCTCCCCAAACCAGGCCTCCAAGCCAGGTGCCACCCTCGCCTCACAGCCCCGGCCCCCTGT
GCAGGGCCGTAGTACCTCCCAGCAGGGTGAAGAGTCCAAGAAGCCAGCACCACCCCATCCGCATCTCAACAAATCTCAGTCCCTGACTAA
CAGCCTCAGCACATCCGACACCTCCCAGCGTGGGACCCCAAGTGAAGACGAGGCCAAGGCTGAAACCATCCGCAACCTGAGGAAGTCTTT
TGCCAGCCTGTTCTCTGACTAACGCCATCCAGGCTGGGAGGGGAAGAGTGCTCTGCTACACTCGTCCCCCTCCTGCCTCATCTTCCTTCT
CAGCCTTGGTTCCTGATGGGAACAGAATGGAGGGCCTGAGAACATACTTTCTAAATGCCTTTGACCCAGGAACCGATTATCTATATTTGT
TCCCATTTTCCTTCACCGTGACATTCCAGCATTGTCTGACTGTGAGGTGGGCCTTTGAGAGCCTCCAGGTTCCTCAAAACAGGCCTGAGC
GATGGGCATCACACCCTCTGCCTACCCACGTGCCTGCTTACCTGCCAGATAACCAAGTGAGATGTCTGCGAGTGGCTAGTTTTCACATTC
TTACTAGTGTTTGGCTCACCTTTGGGCAAAGGCCCCCTCTAGGCCTTGCCCCACCTCCATCAAACGCAGACACTGTAGTCAGACCTCAGC
AATATAGGAGGCAATAATCTTTTAACAGTGTTTTGCAAACAAACAAAAAGAGAAAAATCCCAGCCAGGGGAACTCGCCACCTGCCCACGC
TAGTTCCATCCACGCTCAAGACCCGCCCTTAGACCAGGCAGGCAAAGGCCCCCATCACACTCGGCCACTAGTGGGGTCCTGAGGCCAAGA
AAGAAACCAGACCCTGTATGACAAGTGGGGTCTTTCAGAACACGACAGAAACAGGGGGGCCCTTGTAATGCCACTCATACTCAGAGCATT
ATTCTTATTTGGACAGCCAAGGGCAGATCACAGGTTATTGTAGGAATAAAGACTAGTTTACAAAGGAGAAAGAGGCCCTGGACTTCCCAA
GGAAAGGGTCAGGTTAGGGCTCCTGTACCCATTCTGTTCCACCACTGTTTGATCTCTCTGGCCTCCCACCAGGAATGCCGTTTCCTTTTT
ATGGATCTGTTGGGAACCAGAGAGAATCAACAGATCAATGACATAGGATCCGAAGTGCAATGATAGTCACTTCTAGTTTGGCATTTCACA
AACTCTGTACAGCAAGGTATTGGTAGGTTACTCAATTTCAAAAGGGCCCCATGGCCAAATATGTTTAGGAACCGCTGTTTGTATTTCTTT

>30206_30206_6_FGF12-SYN3_FGF12_chr3_192053150_ENST00000454309_SYN3_chr22_32992722_ENST00000358763_length(amino acids)=481AA_BP=138
MAAAIASSLIRQKRQARESNSDRVSASKRRSSPSKDGRSLCERHVLGVFSKVRFCSGRKRPVRRRPEPQLKGIVTRLFSQQGYFLQMHPD
GTIDGTKDENSDYTLFNLIPVGLRVVAIQGVKASLYVAMNGEGYLYSSVTAPHFPVVVKLGHAHAGMGKIKVENQLDFQDITSVVAMAKT
YATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDS
SMPLIGEHVEEDRQLMADLVVSKMSQLPMPGGTAPSPLRPWAPQIKSAKSPGQAQLGPQLGQPQPRPPPQGGPRQAQSPQPQRSGSPSQQ
RLSPQGQQPLSPQSGSPQQQRSPGSPQLSRASSGSSPNQASKPGATLASQPRPPVQGRSTSQQGEESKKPAPPHPHLNKSQSLTNSLSTS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FGF12-SYN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FGF12-SYN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FGF12-SYN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGF12C4310685EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 473CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGF12C0019209Hepatomegaly1CTD_human
HgeneFGF12C0543888Epileptic encephalopathy1GENOMICS_ENGLAND
TgeneC0036341Schizophrenia4PSYGENET
TgeneC0005586Bipolar Disorder1PSYGENET
TgeneC0809983Schizophrenia and related disorders1PSYGENET