|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ALDOA-ACTA1 (FusionGDB2 ID:HG226TG58) |
Fusion Gene Summary for ALDOA-ACTA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ALDOA-ACTA1 | Fusion gene ID: hg226tg58 | Hgene | Tgene | Gene symbol | ALDOA | ACTA1 | Gene ID | 226 | 58 |
| Gene name | aldolase, fructose-bisphosphate A | actin alpha 1, skeletal muscle | |
| Synonyms | ALDA|GSD12|HEL-S-87p | ACTA|ASMA|CFTD|CFTD1|CFTDM|MPFD|NEM1|NEM2|NEM3|SHPM | |
| Cytomap | ('ALDOA')('ACTA1') 16p11.2 | 1q42.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fructose-bisphosphate aldolase Aaldolase A, fructose-bisphosphateepididymis secretory sperm binding protein Li 87pfructose-1,6-bisphosphate triosephosphate-lyaselung cancer antigen NY-LU-1muscle-type aldolase | actin, alpha skeletal musclenemaline myopathy type 3 | |
| Modification date | 20200313 | 20200328 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000338110, ENST00000395240, ENST00000395248, ENST00000412304, ENST00000563060, ENST00000564546, ENST00000564595, ENST00000566897, ENST00000569545, ENST00000569798, ENST00000575627, | ||
| Fusion gene scores | * DoF score | 37 X 23 X 12=10212 | 3 X 3 X 2=18 |
| # samples | 42 | 3 | |
| ** MAII score | log2(42/10212*10)=-4.603732304741 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ALDOA [Title/Abstract] AND ACTA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ALDOA(30080868)-ACTA1(229567339), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ALDOA-ACTA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ALDOA-ACTA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ALDOA-ACTA1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ALDOA-ACTA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ALDOA | GO:0008360 | regulation of cell shape | 9244396 |
| Hgene | ALDOA | GO:0030388 | fructose 1,6-bisphosphate metabolic process | 9244396|14766013 |
| Fusion gene breakpoints across ALDOA (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across ACTA1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Top |
Fusion Gene ORF analysis for ALDOA-ACTA1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000338110 | ENST00000366683 | ALDOA | chr16 | 30080868 | + | ACTA1 | chr1 | 229567339 | - | 0.005463678 | 0.9945364 |
| ENST00000395248 | ENST00000366683 | ALDOA | chr16 | 30080868 | + | ACTA1 | chr1 | 229567339 | - | 0.16749176 | 0.83250827 |
| ENST00000566897 | ENST00000366683 | ALDOA | chr16 | 30080868 | + | ACTA1 | chr1 | 229567339 | - | 0.008634299 | 0.9913657 |
| ENST00000569545 | ENST00000366683 | ALDOA | chr16 | 30080868 | + | ACTA1 | chr1 | 229567339 | - | 0.002493806 | 0.9975062 |
| ENST00000563060 | ENST00000366683 | ALDOA | chr16 | 30080868 | + | ACTA1 | chr1 | 229567339 | - | 0.004807414 | 0.99519265 |
| ENST00000412304 | ENST00000366683 | ALDOA | chr16 | 30080868 | + | ACTA1 | chr1 | 229567339 | - | 0.005906439 | 0.9940936 |
| ENST00000564546 | ENST00000366683 | ALDOA | chr16 | 30080868 | + | ACTA1 | chr1 | 229567339 | - | 0.005532181 | 0.99446785 |
| ENST00000564595 | ENST00000366683 | ALDOA | chr16 | 30080868 | + | ACTA1 | chr1 | 229567339 | - | 0.004921446 | 0.99507856 |
| ENST00000569798 | ENST00000366683 | ALDOA | chr16 | 30080868 | + | ACTA1 | chr1 | 229567339 | - | 0.003299014 | 0.99670094 |
| ENST00000395240 | ENST00000366683 | ALDOA | chr16 | 30080868 | + | ACTA1 | chr1 | 229567339 | - | 0.00315741 | 0.9968426 |
Top |
Fusion Genomic Features for ALDOA-ACTA1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
Top |
Fusion Protein Features for ALDOA-ACTA1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:30080868/chr1:229567339) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for ALDOA-ACTA1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >3932_3932_1_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000338110_ACTA1_chr1_229567339_ENST00000366683_length(transcript)=2181nt_BP=1837nt AAACACCGCTCTGGTCACCATGGCAACAGCGGGATGCCGCGAACGGCTTCTGGGCGGGGCCGGTCCCTCGGACGATTGGACCTAGCTTGG CGCGGAATCCGTGAATTGCCCGCGGCCCGAGGGTGCAGCTCCCGGACTGACTGGCTCTGCCCTTCCCCATGGACGCCTCCTCTAGCCCGT GGAATCCAACCCCGGCTCCTGTCAGCAGCCCTCCCCTGCTGCTCCCCATCCCTGCCATCGTCTTCATCGCTGTGGGCATCTATTTGTTGC TGCTGGGTCTAGTCCTGCTGACTAGGAACTGCCTGCTGGCCCAGGGCTGCTGCGCGGACGGTAGCTCCCCCTGCAGGAAGCAAGGTTCCT CCGGGCCCCCAGACTGCTGCTGGACCTGTGCAGAAGCCTGCAACTTTCCTCTGCCTAGCCCGGCCCACTTCCTGGATGCTTGCTGCCCCC AGCCCACCAGAGCTGACTGGGCACCTCGCTGCCCCCGCTGCTGCCCACTCTGCGACTGTGCCTGTACGTGCCAGCTCCCCGACTGCCAGA GCCTCAACTGTCTCTGCTTCGAGATCAAGCTCCGATGAGGACCCAGGGCCCCTGCCCTCTGGGGAGCGGCCAGCCCCCAGGGCCCATGTG CCCTCCTCCCTGAAGAGCCTTTCCCCACGCCACTGGAACCACAGATGGCCTGCCGAGCACCCAGGCCTGGGAACTGGAAGTGGCAGCGCA GGGCCTGGCTCCCTGCAGGGCAGGACTCTTGGCCGGCTGGACGGCAGCTCCTCTGGAGGGCCAGAAAAGAGAGGGGCTAGTGCTCGGGCA GGTGCCCTGGCTTCCCTTCCCCTCCACACGTCAACGATTCTATTTGAAGTTGGGCAGGGGGGTGGCGCTGCTCACCACACACAAGTGTTA TAGGAGGAGTCTGGCCCTTGAGTACCGGGTACGCAGGGGTGCCTCAACCACACTCCGTCCACGGACTCTCCGTTATTTTAGGAGGTCCCT GGCCAAAGATTTATTTCTCTTGACAACCAAGGGCCTCCGTCTGGATTTCCAAGGAAGAATTTCCTCTGAAGCACCGGAACTTGCTACTAC CAGCACCATGCCCTACCAATATCCAGCACTGACCCCGGAGCAGAAGAAGGAGCTGTCTGACATCGCTCACCGCATCGTGGCACCTGGCAA GGGCATCCTGGCTGCAGATGAGTCCACTGGGAGCATTGCCAAGCGGCTGCAGTCCATTGGCACCGAGAACACCGAGGAGAACCGGCGCTT CTACCGCCAGCTGCTGCTGACAGCTGACGACCGCGTGAACCCCTGCATTGGGGGTGTCATCCTCTTCCATGAGACACTCTACCAGAAGGC GGATGATGGGCGTCCCTTCCCCCAAGTTATCAAATCCAAGGGCGGTGTTGTGGGCATCAAGGTAGACAAGGGCGTGGTCCCCCTGGCAGG GACAAATGGCGAGACTACCACCCAAGGGTTGGATGGGCTGTCTGAGCGCTGTGCCCAGTACAAGAAGGACGGAGCTGACTTCGCCAAGTG GCGTTGTGTGCTGAAGATTGGGGAACACACCCCCTCAGCCCTCGCCATCATGGAAAATGCCAATGTTCTGGCCCGTTATGCCAGTATCTG CCAGCAGAATGGCATTGTGCCCATCGTGGAGCCTGAGATCCTCCCTGATGGGGACCATGACTTGAAGCGCTGCCAGTATGTGACCGAGAA GAAGGCACCTTGCTGAAGCCCAACATGGTCACCCCAGGCCATGCTTGCACTCAGAAGTTTTCTCATGAGGAGATTGCCATGGCGACCGTC ACAGCGCTGCGCCGCACAGTGCCCCCCGCTGTCACTGCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCACCAAGCAGGAGTACG ACGAGGCCGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGACACACTCCACCTCCAGCACGCGACTTCTCAGGACGACGAATCTTCTCA ATGGGGGGGCGGCTGAGCTCCAGCCACCCCGCAGTCACTTTCTTTGTAACAACTTCCGTTGCTGCCATCGTAAACTGACACAGTGTTTAT AACGTGTACATACATTAACTTATTACCTCATTTTGTTATTTTTCGAAACAAAGCCCTGTGGAAGAAAATGGAAAACTTGAAGAAGCATTA >3932_3932_1_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000338110_ACTA1_chr1_229567339_ENST00000366683_length(amino acids)=348AA_BP= MPSTQAWELEVAAQGLAPCRAGLLAGWTAAPLEGQKREGLVLGQVPWLPFPSTRQRFYLKLGRGVALLTTHKCYRRSLALEYRVRRGAST TLRPRTLRYFRRSLAKDLFLLTTKGLRLDFQGRISSEAPELATTSTMPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRL QSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSER -------------------------------------------------------------- >3932_3932_2_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000395240_ACTA1_chr1_229567339_ENST00000366683_length(transcript)=1278nt_BP=934nt CCCCTTCCGAGGCTAAATCGGCTGCGTTCCTCTCGGAACGCGCCGCAGAAGGGGTCCTGGTGACGAGTCCCGCGTTCTCTCCTTGAATCC ACTCGCCAGCCCGCCGCCCTCTGCCGCCGCACCCTGCACACCCGCCCCTCTCCTGTGCCAGGAACTTGCTACTACCAGCACCATGCCCTA CCAATATCCAGCACTGACCCCGGAGCAGAAGAAGGAGCTGTCTGACATCGCTCACCGCATCGTGGCACCTGGCAAGGGCATCCTGGCTGC AGATGAGTCCACTGGGAGCATTGCCAAGCGGCTGCAGTCCATTGGCACCGAGAACACCGAGGAGAACCGGCGCTTCTACCGCCAGCTGCT GCTGACAGCTGACGACCGCGTGAACCCCTGCATTGGGGGTGTCATCCTCTTCCATGAGACACTCTACCAGAAGGCGGATGATGGGCGTCC CTTCCCCCAAGTTATCAAATCCAAGGGCGGTGTTGTGGGCATCAAGGTAGACAAGGGCGTGGTCCCCCTGGCAGGGACAAATGGCGAGAC TACCACCCAAGGGTTGGATGGGCTGTCTGAGCGCTGTGCCCAGTACAAGAAGGACGGAGCTGACTTCGCCAAGTGGCGTTGTGTGCTGAA GATTGGGGAACACACCCCCTCAGCCCTCGCCATCATGGAAAATGCCAATGTTCTGGCCCGTTATGCCAGTATCTGCCAGCAGGTGGGCCT GCAGAATGGCATTGTGCCCATCGTGGAGCCTGAGATCCTCCCTGATGGGGACCATGACTTGAAGCGCTGCCAGTATGTGACCGAGAAGAA GGCACCTTGCTGAAGCCCAACATGGTCACCCCAGGCCATGCTTGCACTCAGAAGTTTTCTCATGAGGAGATTGCCATGGCGACCGTCACA GCGCTGCGCCGCACAGTGCCCCCCGCTGTCACTGCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCACCAAGCAGGAGTACGACG AGGCCGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGACACACTCCACCTCCAGCACGCGACTTCTCAGGACGACGAATCTTCTCAATG GGGGGGCGGCTGAGCTCCAGCCACCCCGCAGTCACTTTCTTTGTAACAACTTCCGTTGCTGCCATCGTAAACTGACACAGTGTTTATAAC GTGTACATACATTAACTTATTACCTCATTTTGTTATTTTTCGAAACAAAGCCCTGTGGAAGAAAATGGAAAACTTGAAGAAGCATTAAAG >3932_3932_2_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000395240_ACTA1_chr1_229567339_ENST00000366683_length(amino acids)=246AA_BP= MNPLASPPPSAAAPCTPAPLLCQELATTSTMPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYR QLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRC -------------------------------------------------------------- >3932_3932_3_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000395248_ACTA1_chr1_229567339_ENST00000366683_length(transcript)=2238nt_BP=1894nt ATGCCGCGAACGGCTTCTGGGCGGGGCCGGTCCCTCGGACGATTGGACCTAGCTTGGCGCGGAATCCGTGAATTGCCCGCGGCCCGAGGG TGCAGCTCCCGGACTGACTGGCTCTGCCCTTCCCCATGGACGCCTCCTCTAGCCCGTGGAATCCAACCCCGGCTCCTGTCAGCAGCCCTC CCCTGCTGCTCCCCATCCCTGCCATCGTCTTCATCGCTGTGGGCATCTATTTGTTGCTGCTGGGTCTAGTCCTGCTGACTAGGAACTGCC TGCTGGCCCAGGGCTGCTGCGCGGACGGTAGCTCCCCCTGCAGGAAGCAAGGTTCCTCCGGGCCCCCAGACTGCTGCTGGACCTGTGCAG AAGCCTGCAACTTTCCTCTGCCTAGCCCGGCCCACTTCCTGGATGCTTGCTGCCCCCAGCCCACCAGAGCTGGCTTCCATTCTGGTGATG GAGAGAGAGAAATAACCAGGCCATTACAACAGAGGGTGAGAAATGACGTGCTATGGAGCAGCGGTTGCTCAGCCCTGCATGCGATCAGAA GCAGGACTGGGCACCTCGCTGCCCCCGCTGCTGCCCACTCTGCGACTGTGCCTGTACGTGCCAGCTCCCCGACTGCCAGAGCCTCAACTG TCTCTGCTTCGAGATCAAGCTCCGATGAGGACCCAGGGCCCCTGCCCTCTGGGGAGCGGCCAGCCCCCAGGGCCCATGTGCCCTCCTCCC TGAAGAGCCTTTCCCCACGCCACTGGAACCACAGATGGCCTGCCGAGCACCCAGGCCTGGGAACTGGAAGTGGCAGCGCAGGGCCTGGCT CCCTGCAGGGCAGGACTCTTGGCCGGCTGGACGGCAGCTCCTCTGGAGGGCCAGAAAAGAGAGGGGCTAGTGCTCGGGTCCCTGGCCAAA GATTTATTTCTCTTGACAACCAAGGGCCTCCGTCTGGATTTCCAAGGAAGAATTTCCTCTGAAGCACCGGCAAGGTGACCCCATGGCAAG GCGCAAGCCAGAAGGGTCCAGCTTCAACATGACCCACCTGTCCATGGCTATGGCCTTTTCCTTTCCCCCAGTTGCCAGTGGGCAACTCCA CCCTCAGCTGGGCAACACCCAGCACCAGACAGAGTTAGGAAAGGAACTTGCTACTACCAGCACCATGCCCTACCAATATCCAGCACTGAC CCCGGAGCAGAAGAAGGAGCTGTCTGACATCGCTCACCGCATCGTGGCACCTGGCAAGGGCATCCTGGCTGCAGATGAGTCCACTGGGAG CATTGCCAAGCGGCTGCAGTCCATTGGCACCGAGAACACCGAGGAGAACCGGCGCTTCTACCGCCAGCTGCTGCTGACAGCTGACGACCG CGTGAACCCCTGCATTGGGGGTGTCATCCTCTTCCATGAGACACTCTACCAGAAGGCGGATGATGGGCGTCCCTTCCCCCAAGTTATCAA ATCCAAGGGCGGTGTTGTGGGCATCAAGGTAGACAAGGGCGTGGTCCCCCTGGCAGGGACAAATGGCGAGACTACCACCCAAGGGTTGGA TGGGCTGTCTGAGCGCTGTGCCCAGTACAAGAAGGACGGAGCTGACTTCGCCAAGTGGCGTTGTGTGCTGAAGATTGGGGAACACACCCC CTCAGCCCTCGCCATCATGGAAAATGCCAATGTTCTGGCCCGTTATGCCAGTATCTGCCAGCAGAATGGCATTGTGCCCATCGTGGAGCC TGAGATCCTCCCTGATGGGGACCATGACTTGAAGCGCTGCCAGTATGTGACCGAGAAGAAGGCACCTTGCTGAAGCCCAACATGGTCACC CCAGGCCATGCTTGCACTCAGAAGTTTTCTCATGAGGAGATTGCCATGGCGACCGTCACAGCGCTGCGCCGCACAGTGCCCCCCGCTGTC ACTGCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCACCAAGCAGGAGTACGACGAGGCCGGCCCTTCCATCGTCCACCGCAAAT GCTTCTAGACACACTCCACCTCCAGCACGCGACTTCTCAGGACGACGAATCTTCTCAATGGGGGGGCGGCTGAGCTCCAGCCACCCCGCA GTCACTTTCTTTGTAACAACTTCCGTTGCTGCCATCGTAAACTGACACAGTGTTTATAACGTGTACATACATTAACTTATTACCTCATTT >3932_3932_3_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000395248_ACTA1_chr1_229567339_ENST00000366683_length(amino acids)=293AA_BP= MVLGVAQLRVELPTGNWGKGKGHSHGQVGHVEAGPFWLAPCHGVTLPVLQRKFFLGNPDGGPWLSREINLWPGTRALAPLFSGPPEELPS SRPRVLPCREPGPALPLPVPRPGCSAGHLWFQWRGERLFREEGTWALGAGRSPEGRGPGSSSELDLEAETVEALAVGELARTGTVAEWAA AGAARCPVLLLIACRAEQPLLHSTSFLTLCCNGLVISLSPSPEWKPALVGWGQQASRKWAGLGRGKLQASAQVQQQSGGPEEPCFLQGEL -------------------------------------------------------------- >3932_3932_4_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000412304_ACTA1_chr1_229567339_ENST00000366683_length(transcript)=1403nt_BP=1059nt GAAGCACCGGTGAGTGGGCAGGGGCTCCCTCCCCATCAATAGGGCCGACCCAAGTCTTCCTCCCCCTTCCCCCATGCCGGGCCCCACGAT AGTGTGAATGTCAGGGGCTTCAGGTTTCCCTAAATATAGGTCCCTGCCAGAGGATCCGTGGCGGGAAAAGGGCAGGGGTCATTAGAGAAG ATCGGGGACACATGTGGGGCGGGCAGGAGCTGCCTTATAACCAGCCCGGGAACCCCTAGCTCACTCGCTGCTGACCAGGCTCTGCCGGCT CCTTCGGCCTCGCCGCAGGAACTTGCTACTACCAGCACCATGCCCTACCAATATCCAGCACTGACCCCGGAGCAGAAGAAGGAGCTGTCT GACATCGCTCACCGCATCGTGGCACCTGGCAAGGGCATCCTGGCTGCAGATGAGTCCACTGGGAGCATTGCCAAGCGGCTGCAGTCCATT GGCACCGAGAACACCGAGGAGAACCGGCGCTTCTACCGCCAGCTGCTGCTGACAGCTGACGACCGCGTGAACCCCTGCATTGGGGGTGTC ATCCTCTTCCATGAGACACTCTACCAGAAGGCGGATGATGGGCGTCCCTTCCCCCAAGTTATCAAATCCAAGGGCGGTGTTGTGGGCATC AAGGTAGACAAGGGCGTGGTCCCCCTGGCAGGGACAAATGGCGAGACTACCACCCAAGGGTTGGATGGGCTGTCTGAGCGCTGTGCCCAG TACAAGAAGGACGGAGCTGACTTCGCCAAGTGGCGTTGTGTGCTGAAGATTGGGGAACACACCCCCTCAGCCCTCGCCATCATGGAAAAT GCCAATGTTCTGGCCCGTTATGCCAGTATCTGCCAGCAGAATGGCATTGTGCCCATCGTGGAGCCTGAGATCCTCCCTGATGGGGACCAT GACTTGAAGCGCTGCCAGTATGTGACCGAGAAGAAGGCACCTTGCTGAAGCCCAACATGGTCACCCCAGGCCATGCTTGCACTCAGAAGT TTTCTCATGAGGAGATTGCCATGGCGACCGTCACAGCGCTGCGCCGCACAGTGCCCCCCGCTGTCACTGCCTGGCCTCGCTGTCCACCTT CCAGCAGATGTGGATCACCAAGCAGGAGTACGACGAGGCCGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGACACACTCCACCTCCAG CACGCGACTTCTCAGGACGACGAATCTTCTCAATGGGGGGGCGGCTGAGCTCCAGCCACCCCGCAGTCACTTTCTTTGTAACAACTTCCG TTGCTGCCATCGTAAACTGACACAGTGTTTATAACGTGTACATACATTAACTTATTACCTCATTTTGTTATTTTTCGAAACAAAGCCCTG >3932_3932_4_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000412304_ACTA1_chr1_229567339_ENST00000366683_length(amino acids)=228AA_BP= MPAPSASPQELATTSTMPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCI GGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAI -------------------------------------------------------------- >3932_3932_5_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000563060_ACTA1_chr1_229567339_ENST00000366683_length(transcript)=1347nt_BP=1003nt TCCTTCTTAAAAAAAACCAGGGCTCCAGAGAATCAGAACAGCCACCATCACCGCAGGGAGTCAAGGGAGGAGGGAGATTAGAGAAGGAGC CAGGGAGGGTGGCAGGGAGGCCACGTGATCCGAGTCCCCTCACCCCTTTCCTTCCCACAGGTCCCTGGCCAAAGATTTATTTCTCTTGAC AACCAAGGGCCTCCGTCTGGATTTCCAAGGAAGAATTTCCTCTGAAGCACCGGAACTTGCTACTACCAGCACCATGCCCTACCAATATCC AGCACTGACCCCGGAGCAGAAGAAGGAGCTGTCTGACATCGCTCACCGCATCGTGGCACCTGGCAAGGGCATCCTGGCTGCAGATGAGTC CACTGGGAGCATTGCCAAGCGGCTGCAGTCCATTGGCACCGAGAACACCGAGGAGAACCGGCGCTTCTACCGCCAGCTGCTGCTGACAGC TGACGACCGCGTGAACCCCTGCATTGGGGGTGTCATCCTCTTCCATGAGACACTCTACCAGAAGGCGGATGATGGGCGTCCCTTCCCCCA AGTTATCAAATCCAAGGGCGGTGTTGTGGGCATCAAGGTAGACAAGGGCGTGGTCCCCCTGGCAGGGACAAATGGCGAGACTACCACCCA AGGGTTGGATGGGCTGTCTGAGCGCTGTGCCCAGTACAAGAAGGACGGAGCTGACTTCGCCAAGTGGCGTTGTGTGCTGAAGATTGGGGA ACACACCCCCTCAGCCCTCGCCATCATGGAAAATGCCAATGTTCTGGCCCGTTATGCCAGTATCTGCCAGCAGAATGGCATTGTGCCCAT CGTGGAGCCTGAGATCCTCCCTGATGGGGACCATGACTTGAAGCGCTGCCAGTATGTGACCGAGAAGAAGGCACCTTGCTGAAGCCCAAC ATGGTCACCCCAGGCCATGCTTGCACTCAGAAGTTTTCTCATGAGGAGATTGCCATGGCGACCGTCACAGCGCTGCGCCGCACAGTGCCC CCCGCTGTCACTGCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCACCAAGCAGGAGTACGACGAGGCCGGCCCTTCCATCGTCC ACCGCAAATGCTTCTAGACACACTCCACCTCCAGCACGCGACTTCTCAGGACGACGAATCTTCTCAATGGGGGGGCGGCTGAGCTCCAGC CACCCCGCAGTCACTTTCTTTGTAACAACTTCCGTTGCTGCCATCGTAAACTGACACAGTGTTTATAACGTGTACATACATTAACTTATT >3932_3932_5_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000563060_ACTA1_chr1_229567339_ENST00000366683_length(amino acids)=245AA_BP= MAKDLFLLTTKGLRLDFQGRISSEAPELATTSTMPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRR FYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAK -------------------------------------------------------------- >3932_3932_6_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000564546_ACTA1_chr1_229567339_ENST00000366683_length(transcript)=1895nt_BP=1551nt TCGCCTCCGCGCGCCGCTAGTTCCGCCGCCTTCTCGCGCTCCCTGCGTGTCCTCTCGATGCCCTTTCCTCCGCCTCCCTTACGCCTGGGC CAGTGACAGGGTGTCGGCTCCGCGCCGATTCAGCCCGCGGGCGAGGCAGGCTAACGCACGACTGCGCGATGTGGCCCCTATGGTGACACG CGCTGCAGCCGCGAAGACCGGAAGCTGGGGCGGCCCCGGGCCGCGCGCGCTGGGCCTGGGAGGCGAAACTCAGCTTCCTTCGTTTCCGAC TTTTCCATCCGCGTCCTCCACTTCCCCGTTCCGCCCTCCCCCATTGCCAACATTCTGGCTGAGTCACGGCGCCCCAGAGCGCGCCAGGCT GGGGGAAAGGAGCAGAAGGGAGGGCCCTAGCGACCCGCGGGATGTGGTCCGAGTCACGTCCGAGGGGGGTGGGGAGGGATCGTGTTCTCG GCGCCCGCCCCTTCCTAGCGCGGCCTCTGGGCTGCGCCTCTCGGGGGCGGCCCGTAGCCCAGTCCGTCGCCTGCCATTGGACGCCGCCCG CTCCTCGTAAAGGAAAAAGCTCGGCGGAGGGCGGAGTGGTGCCTTTAAAAGGCCGGGCGCCGCCTTCCGCCTGCCCGCCTCCTGCGCCGC CCCTTCCGAGGCTAAATCGGCTGCGTTCCTCTCGGAACGCGCCGCAGAAGGGGTCCTGGTGACGAGTCCCGCGTTCTCTCCTTGAATCCA CTCGCCAGCCCGCCGCCCTCTGCCGCCGCACCCTGCACACCCGCCCCTCTCCTGTGCCAGGAACTTGCTACTACCAGCACCATGCCCTAC CAATATCCAGCACTGACCCCGGAGCAGAAGAAGGAGCTGTCTGACATCGCTCACCGCATCGTGGCACCTGGCAAGGGCATCCTGGCTGCA GATGAGTCCACTGGGAGCATTGCCAAGCGGCTGCAGTCCATTGGCACCGAGAACACCGAGGAGAACCGGCGCTTCTACCGCCAGCTGCTG CTGACAGCTGACGACCGCGTGAACCCCTGCATTGGGGGTGTCATCCTCTTCCATGAGACACTCTACCAGAAGGCGGATGATGGGCGTCCC TTCCCCCAAGTTATCAAATCCAAGGGCGGTGTTGTGGGCATCAAGGTAGACAAGGGCGTGGTCCCCCTGGCAGGGACAAATGGCGAGACT ACCACCCAAGGGTTGGATGGGCTGTCTGAGCGCTGTGCCCAGTACAAGAAGGACGGAGCTGACTTCGCCAAGTGGCGTTGTGTGCTGAAG ATTGGGGAACACACCCCCTCAGCCCTCGCCATCATGGAAAATGCCAATGTTCTGGCCCGTTATGCCAGTATCTGCCAGCAGAATGGCATT GTGCCCATCGTGGAGCCTGAGATCCTCCCTGATGGGGACCATGACTTGAAGCGCTGCCAGTATGTGACCGAGAAGAAGGCACCTTGCTGA AGCCCAACATGGTCACCCCAGGCCATGCTTGCACTCAGAAGTTTTCTCATGAGGAGATTGCCATGGCGACCGTCACAGCGCTGCGCCGCA CAGTGCCCCCCGCTGTCACTGCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCACCAAGCAGGAGTACGACGAGGCCGGCCCTTC CATCGTCCACCGCAAATGCTTCTAGACACACTCCACCTCCAGCACGCGACTTCTCAGGACGACGAATCTTCTCAATGGGGGGGCGGCTGA GCTCCAGCCACCCCGCAGTCACTTTCTTTGTAACAACTTCCGTTGCTGCCATCGTAAACTGACACAGTGTTTATAACGTGTACATACATT AACTTATTACCTCATTTTGTTATTTTTCGAAACAAAGCCCTGTGGAAGAAAATGGAAAACTTGAAGAAGCATTAAAGTCATTCTGTTAAG >3932_3932_6_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000564546_ACTA1_chr1_229567339_ENST00000366683_length(amino acids)=242AA_BP= MNPLASPPPSAAAPCTPAPLLCQELATTSTMPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYR QLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRC -------------------------------------------------------------- >3932_3932_7_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000564595_ACTA1_chr1_229567339_ENST00000366683_length(transcript)=1463nt_BP=1119nt AAAAGGCCGGGCGCCGCCTTCCGCCTGCCCGCCTCCTGCGCCGCCCCTTCCGAGGCTAAATCGGCTGCGTTCCTCTCGGAACGCGCCGCA GAAGGGGTCCTGGTGACGAGTCCCGCGTTCTCTCCTTGAATCCACTCGCCAGCCCGCCGCCCTCTGCCGCCGCACCCTGCACACCCGCCC CTCTCCTGTGCCAGGCAAGGTGACCCCATGGCAAGGCGCAAGCCAGAAGGGTCCAGCTTCAACATGACCCACCTGTCCATGGCTATGGCC TTTTCCTTTCCCCCAGTTGCCAGTGGGCAACTCCACCCTCAGCTGGGCAACACCCAGCACCAGACAGAGTTAGGAAAGGAACTTGCTACT ACCAGCACCATGCCCTACCAATATCCAGCACTGACCCCGGAGCAGAAGAAGGAGCTGTCTGACATCGCTCACCGCATCGTGGCACCTGGC AAGGGCATCCTGGCTGCAGATGAGTCCACTGGGAGCATTGCCAAGCGGCTGCAGTCCATTGGCACCGAGAACACCGAGGAGAACCGGCGC TTCTACCGCCAGCTGCTGCTGACAGCTGACGACCGCGTGAACCCCTGCATTGGGGGTGTCATCCTCTTCCATGAGACACTCTACCAGAAG GCGGATGATGGGCGTCCCTTCCCCCAAGTTATCAAATCCAAGGGCGGTGTTGTGGGCATCAAGGTAGACAAGGGCGTGGTCCCCCTGGCA GGGACAAATGGCGAGACTACCACCCAAGGGTTGGATGGGCTGTCTGAGCGCTGTGCCCAGTACAAGAAGGACGGAGCTGACTTCGCCAAG TGGCGTTGTGTGCTGAAGATTGGGGAACACACCCCCTCAGCCCTCGCCATCATGGAAAATGCCAATGTTCTGGCCCGTTATGCCAGTATC TGCCAGCAGAATGGCATTGTGCCCATCGTGGAGCCTGAGATCCTCCCTGATGGGGACCATGACTTGAAGCGCTGCCAGTATGTGACCGAG AAGAAGGCACCTTGCTGAAGCCCAACATGGTCACCCCAGGCCATGCTTGCACTCAGAAGTTTTCTCATGAGGAGATTGCCATGGCGACCG TCACAGCGCTGCGCCGCACAGTGCCCCCCGCTGTCACTGCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCACCAAGCAGGAGTA CGACGAGGCCGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGACACACTCCACCTCCAGCACGCGACTTCTCAGGACGACGAATCTTCT CAATGGGGGGGCGGCTGAGCTCCAGCCACCCCGCAGTCACTTTCTTTGTAACAACTTCCGTTGCTGCCATCGTAAACTGACACAGTGTTT ATAACGTGTACATACATTAACTTATTACCTCATTTTGTTATTTTTCGAAACAAAGCCCTGTGGAAGAAAATGGAAAACTTGAAGAAGCAT >3932_3932_7_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000564595_ACTA1_chr1_229567339_ENST00000366683_length(amino acids)=284AA_BP= MPPHPAHPPLSCARQGDPMARRKPEGSSFNMTHLSMAMAFSFPPVASGQLHPQLGNTQHQTELGKELATTSTMPYQYPALTPEQKKELSD IAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIK VDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHD -------------------------------------------------------------- >3932_3932_8_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000566897_ACTA1_chr1_229567339_ENST00000366683_length(transcript)=2246nt_BP=1902nt CGCGAACGGCTTCTGGGCGGGGCCGGTCCCTCGGACGATTGGACCTAGCTTGGCGCGGAATCCGTGAATTGCCCGCGGCCCGAGGGTGCA GGTGATGGGTGCTGACCGACTGGGGAAGCCCGGAGTGTGGGGACTGAGGAGGGGAGTGGCCTGGGGCGCGCTGGAGCCTGCGAGGAAGGC GCCGCCTCGGATCCCCCGCCCCCCATTCCCCTTCCCGAATTCCACCCTCCGGCCCAGCCATGGCCTCAGTTTCCCCAAACAGGAAAGGGA AGGAGGGTGGGCACCCCGGTCTAACGGTGCCTCTCAGCCTCTGAGACCCAGAACCTTCCTTCTGCAGCTCCCGGACTGACTGGCTCTGCC CTTCCCCATGGACGCCCAGGGCTGCTGCGCGGACGGTAGCTCCCCCTGCAGGAAGCAAGGTTCCTCCGGGCCCCCAGACTGCTGCTGGAC CTGTGCAGAAGCCTGCAACTTTCCTCTGCCTAGCCCGGCCCACTTCCTGGATGCTTGCTGCCCCCAGCCCACCAGAGCTGACTGGGCACC TCGCTGCCCCCGCTGCTGCCCACTCTGCGACTGTGCCTGTACGTGCCAGCTCCCCGACTGCCAGAGCCTCAACTGTCTCTGCTTCGAGAT CAAGCTCCGATGAGGACCCAGGGCCCCTGCCCTCTGGGGAGCGGCCAGCCCCCAGGGCCCATGTGCCCTCCTCCCTGAAGAGCCTTTCCC CACGCCACTGGAACCACAGATGGCCTGCCGAGCACCCAGGCCTGGGAACTGGAAGTGGCAGCGCAGGGCCTGGCTCCCTGCAGGGCAGGA CTCTTGGCCGGCTGGACGGCAGCTCCTCTGGAGGGCCAGAAAAGAGAGGGGCTAGTGCTCGGGCAGGTGCCCTGGCTTCCCTTCCCCTCC ACACGTCAACGATTCTATTTGAAGTTGGGCAGGGGGGTGGCGCTGCTCACCACACACAAGTGTTATAGGAGGAGTCTGGCCCTTGAGTAC CGGGTACGCAGGGGTGCCTCAACCACACTCCGTCCACGGACTCTCCGTTATTTTAGGAGGTCCCTGGCCAAAGATTTATTTCTCTTGACA ACCAAGGGCCTCCGTCTGGATTTCCAAGGAAGAATTTCCTCTGAAGCACCGGAACTTGCTACTACCAGCACCATGCCCTACCAATATCCA GCACTGACCCCGGAGCAGAAGAAGGAGCTGTCTGACATCGCTCACCGCATCGTGGCACCTGGCAAGGGCATCCTGGCTGCAGATGAGTCC ACTGGGAGCATTGCCAAGCGGCTGCAGTCCATTGGCACCGAGAACACCGAGGAGAACCGGCGCTTCTACCGCCAGCTGCTGCTGACAGCT GACGACCGCGTGAACCCCTGCATTGGGGGTGTCATCCTCTTCCATGAGACACTCTACCAGAAGGCGGATGATGGGCGTCCCTTCCCCCAA GTTATCAAATCCAAGGGCGGTGTTGTGGGCATCAAGGTAGACAAGGGCGTGGTCCCCCTGGCAGGGACAAATGGCGAGACTACCACCCAA GGGTTGGATGGGCTGTCTGAGCGCTGTGCCCAGTACAAGAAGGACGGAGCTGACTTCGCCAAGTGGCGTTGTGTGCTGAAGATTGGGGAA CACACCCCCTCAGCCCTCGCCATCATGGAAAATGCCAATGTTCTGGCCCGTTATGCCAGTATCTGCCAGCAGAATGGCATTGTGCCCATC GTGGAGCCTGAGATCCTCCCTGATGGGGACCATGACTTGAAGCGCTGCCAGTATGTGACCGAGAAGAAGGCACCTTGCTGAAGCCCAACA TGGTCACCCCAGGCCATGCTTGCACTCAGAAGTTTTCTCATGAGGAGATTGCCATGGCGACCGTCACAGCGCTGCGCCGCACAGTGCCCC CCGCTGTCACTGCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCACCAAGCAGGAGTACGACGAGGCCGGCCCTTCCATCGTCCA CCGCAAATGCTTCTAGACACACTCCACCTCCAGCACGCGACTTCTCAGGACGACGAATCTTCTCAATGGGGGGGCGGCTGAGCTCCAGCC ACCCCGCAGTCACTTTCTTTGTAACAACTTCCGTTGCTGCCATCGTAAACTGACACAGTGTTTATAACGTGTACATACATTAACTTATTA >3932_3932_8_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000566897_ACTA1_chr1_229567339_ENST00000366683_length(amino acids)=348AA_BP= MPSTQAWELEVAAQGLAPCRAGLLAGWTAAPLEGQKREGLVLGQVPWLPFPSTRQRFYLKLGRGVALLTTHKCYRRSLALEYRVRRGAST TLRPRTLRYFRRSLAKDLFLLTTKGLRLDFQGRISSEAPELATTSTMPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRL QSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSER -------------------------------------------------------------- >3932_3932_9_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000569545_ACTA1_chr1_229567339_ENST00000366683_length(transcript)=1313nt_BP=969nt AGTACCGGGTACGCAGGGGTGCCTCAACCACACTCCGTCCACGGACTCTCCGTTATTTTAGGAGGTCCCTGGCCAAAGATTTATTTCTCT TGACAACCAAGGGCCTCCGTCTGGATTTCCAAGGAAGAATTTCCTCTGAAGCACCGCCCGCCGCCCTCTGCCGCCGCACCCTGCACACCC GCCCCTCTCCTGTGCCAGGAACTTGCTACTACCAGCACCATGCCCTACCAATATCCAGCACTGACCCCGGAGCAGAAGAAGGAGCTGTCT GACATCGCTCACCGCATCGTGGCACCTGGCAAGGGCATCCTGGCTGCAGATGAGTCCACTGGGAGCATTGCCAAGCGGCTGCAGTCCATT GGCACCGAGAACACCGAGGAGAACCGGCGCTTCTACCGCCAGCTGCTGCTGACAGCTGACGACCGCGTGAACCCCTGCATTGGGGGTGTC ATCCTCTTCCATGAGACACTCTACCAGAAGGCGGATGATGGGCGTCCCTTCCCCCAAGTTATCAAATCCAAGGGCGGTGTTGTGGGCATC AAGGTAGACAAGGGCGTGGTCCCCCTGGCAGGGACAAATGGCGAGACTACCACCCAAGGGTTGGATGGGCTGTCTGAGCGCTGTGCCCAG TACAAGAAGGACGGAGCTGACTTCGCCAAGTGGCGTTGTGTGCTGAAGATTGGGGAACACACCCCCTCAGCCCTCGCCATCATGGAAAAT GCCAATGTTCTGGCCCGTTATGCCAGTATCTGCCAGCAGAATGGCATTGTGCCCATCGTGGAGCCTGAGATCCTCCCTGATGGGGACCAT GACTTGAAGCGCTGCCAGTATGTGACCGAGAAGAAGGCACCTTGCTGAAGCCCAACATGGTCACCCCAGGCCATGCTTGCACTCAGAAGT TTTCTCATGAGGAGATTGCCATGGCGACCGTCACAGCGCTGCGCCGCACAGTGCCCCCCGCTGTCACTGCCTGGCCTCGCTGTCCACCTT CCAGCAGATGTGGATCACCAAGCAGGAGTACGACGAGGCCGGCCCTTCCATCGTCCACCGCAAATGCTTCTAGACACACTCCACCTCCAG CACGCGACTTCTCAGGACGACGAATCTTCTCAATGGGGGGGCGGCTGAGCTCCAGCCACCCCGCAGTCACTTTCTTTGTAACAACTTCCG TTGCTGCCATCGTAAACTGACACAGTGTTTATAACGTGTACATACATTAACTTATTACCTCATTTTGTTATTTTTCGAAACAAAGCCCTG >3932_3932_9_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000569545_ACTA1_chr1_229567339_ENST00000366683_length(amino acids)=240AA_BP= MKHRPPPSAAAPCTPAPLLCQELATTSTMPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQL LLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVL -------------------------------------------------------------- >3932_3932_10_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000569798_ACTA1_chr1_229567339_ENST00000366683_length(transcript)=1271nt_BP=927nt CGCCGCCCCTTCCGAGGCTAAATCGGCTGCGTTCCTCTCGGAACGCGCCGCAGAAGGGGTCCTGGTGACGAGTCCCGCGTTCTCTCCTTG AATCCACTCGCCAGCCCGCCGCCCTCTGCCGCCGCACCCTGCACACCCGCCCCTCTCCTGTGCCAGGAACTTGCTACTACCAGCACCATG CCCTACCAATATCCAGCACTGACCCCGGAGCAGAAGAAGGAGCTGTCTGACATCGCTCACCGCATCGTGGCACCTGGCAAGGGCATCCTG GCTGCAGATGAGTCCACTGGGAGCATTGCCAAGCGGCTGCAGTCCATTGGCACCGAGAACACCGAGGAGAACCGGCGCTTCTACCGCCAG CTGCTGCTGACAGCTGACGACCGCGTGAACCCCTGCATTGGGGGTGTCATCCTCTTCCATGAGACACTCTACCAGAAGGCGGATGATGGG CGTCCCTTCCCCCAAGTTATCAAATCCAAGGGCGGTGTTGTGGGCATCAAGGTAGACAAGGGCGTGGTCCCCCTGGCAGGGACAAATGGC GAGACTACCACCCAAGGGTTGGATGGGCTGTCTGAGCGCTGTGCCCAGTACAAGAAGGACGGAGCTGACTTCGCCAAGTGGCGTTGTGTG CTGAAGATTGGGGAACACACCCCCTCAGCCCTCGCCATCATGGAAAATGCCAATGTTCTGGCCCGTTATGCCAGTATCTGCCAGCAGAAT GGCATTGTGCCCATCGTGGAGCCTGAGATCCTCCCTGATGGGGACCATGACTTGAAGCGCTGCCAGTATGTGACCGAGAAGAAGGCACCT TGCTGAAGCCCAACATGGTCACCCCAGGCCATGCTTGCACTCAGAAGTTTTCTCATGAGGAGATTGCCATGGCGACCGTCACAGCGCTGC GCCGCACAGTGCCCCCCGCTGTCACTGCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCACCAAGCAGGAGTACGACGAGGCCGG CCCTTCCATCGTCCACCGCAAATGCTTCTAGACACACTCCACCTCCAGCACGCGACTTCTCAGGACGACGAATCTTCTCAATGGGGGGGC GGCTGAGCTCCAGCCACCCCGCAGTCACTTTCTTTGTAACAACTTCCGTTGCTGCCATCGTAAACTGACACAGTGTTTATAACGTGTACA TACATTAACTTATTACCTCATTTTGTTATTTTTCGAAACAAAGCCCTGTGGAAGAAAATGGAAAACTTGAAGAAGCATTAAAGTCATTCT >3932_3932_10_ALDOA-ACTA1_ALDOA_chr16_30080868_ENST00000569798_ACTA1_chr1_229567339_ENST00000366683_length(amino acids)=242AA_BP= MNPLASPPPSAAAPCTPAPLLCQELATTSTMPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYR QLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRC -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for ALDOA-ACTA1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | ACTA1 | chr16:30080868 | chr1:229567339 | ENST00000366684 | 0 | 7 | 112_125 | 0 | 378.0 | alpha-actinin | |
| Tgene | ACTA1 | chr16:30080868 | chr1:229567339 | ENST00000366684 | 0 | 7 | 360_372 | 0 | 378.0 | alpha-actinin |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for ALDOA-ACTA1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for ALDOA-ACTA1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ALDOA | C0272066 | Glycogen Storage Disease XII | 7 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Hgene | ALDOA | C0017919 | Glycogen Storage Disease | 3 | GENOMICS_ENGLAND |
| Hgene | ALDOA | C0520572 | Enzymopathy | 2 | GENOMICS_ENGLAND |
| Hgene | ALDOA | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
| Hgene | ALDOA | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Hgene | ALDOA | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Hgene | ALDOA | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Hgene | ALDOA | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Hgene | ALDOA | C0678222 | Breast Carcinoma | 1 | CTD_human |
| Hgene | ALDOA | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| Hgene | ALDOA | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | ALDOA | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
| Tgene | C3711389 | Actin-Accumulation Myopathy | 16 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
| Tgene | C0546264 | Congenital Fiber Type Disproportion | 5 | CTD_human;GENOMICS_ENGLAND;UNIPROT | |
| Tgene | C0007194 | Hypertrophic Cardiomyopathy | 4 | CLINGEN;GENOMICS_ENGLAND | |
| Tgene | C0007193 | Cardiomyopathy, Dilated | 2 | GENOMICS_ENGLAND | |
| Tgene | C0149721 | Left Ventricular Hypertrophy | 1 | CTD_human | |
| Tgene | C0206157 | Myopathies, Nemaline | 1 | GENOMICS_ENGLAND | |
| Tgene | C0270969 | Zebra body myopathy | 1 | ORPHANET | |
| Tgene | C0410180 | Eichsfeld type congenital muscular dystrophy | 1 | ORPHANET | |
| Tgene | C1834339 | Myopathy, Actin, Congenital, with Excess of Thin Myofilaments | 1 | GENOMICS_ENGLAND | |
| Tgene | C2750537 | Myopathy, Actin, Congenital, With Cores | 1 | GENOMICS_ENGLAND | |
| Tgene | C4225181 | MYOPATHY, SCAPULOHUMEROPERONEAL | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies