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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:FHL1-ANXA2 (FusionGDB2 ID:HG2273TG302) |
Fusion Gene Summary for FHL1-ANXA2 |
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Fusion gene information | Fusion gene name: FHL1-ANXA2 | Fusion gene ID: hg2273tg302 | Hgene | Tgene | Gene symbol | FHL1 | ANXA2 | Gene ID | 2273 | 302 |
Gene name | four and a half LIM domains 1 | annexin A2 | |
Synonyms | FCMSU|FHL-1|FHL1A|FHL1B|FLH1A|KYOT|RBMX1A|RBMX1B|SLIM|SLIM-1|SLIM1|SLIMMER|XMPMA | ANX2|ANX2L4|CAL1H|HEL-S-270|LIP2|LPC2|LPC2D|P36|PAP-IV | |
Cytomap | ('FHL1')('ANXA2') Xq26.3 | 15q22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | four and a half LIM domains protein 1LIM protein SLIMMERfour-and-a-half Lin11, Isl-1 and Mec-3 domains 1skeletal muscle LIM-protein 1 | annexin A2annexin IIannexin-2calpactin I heavy chaincalpactin I heavy polypeptidecalpactin-1 heavy chainchromobindin 8epididymis secretory protein Li 270epididymis secretory sperm binding proteinlipocortin IIplacental anticoagulant protein IVpr | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000345434, ENST00000370690, ENST00000394153, ENST00000394155, ENST00000535737, ENST00000543669, ENST00000370676, ENST00000370683, ENST00000477080, ENST00000539015, | ||
Fusion gene scores | * DoF score | 6 X 4 X 3=72 | 33 X 12 X 13=5148 |
# samples | 6 | 39 | |
** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(39/5148*10)=-3.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FHL1 [Title/Abstract] AND ANXA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | FHL1(135252139)-ANXA2(60656722), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FHL1 | GO:0003254 | regulation of membrane depolarization | 18281375 |
Hgene | FHL1 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | 21702045 |
Hgene | FHL1 | GO:0030308 | negative regulation of cell growth | 21702045 |
Hgene | FHL1 | GO:0043268 | positive regulation of potassium ion transport | 18281375 |
Hgene | FHL1 | GO:1901016 | regulation of potassium ion transmembrane transporter activity | 18281375 |
Hgene | FHL1 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle | 21702045 |
Tgene | ANXA2 | GO:0001921 | positive regulation of receptor recycling | 22848640 |
Tgene | ANXA2 | GO:0031340 | positive regulation of vesicle fusion | 2138016 |
Tgene | ANXA2 | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process | 22848640 |
Tgene | ANXA2 | GO:0036035 | osteoclast development | 7961821 |
Tgene | ANXA2 | GO:1905581 | positive regulation of low-density lipoprotein particle clearance | 22848640 |
Tgene | ANXA2 | GO:1905597 | positive regulation of low-density lipoprotein particle receptor binding | 22848640 |
Tgene | ANXA2 | GO:1905602 | positive regulation of receptor-mediated endocytosis involved in cholesterol transport | 22848640 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-AR-A0TS-01A | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
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Fusion Gene ORF analysis for FHL1-ANXA2 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000345434 | ENST00000332680 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000345434 | ENST00000396024 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000345434 | ENST00000421017 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000345434 | ENST00000451270 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000370690 | ENST00000332680 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000370690 | ENST00000396024 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000370690 | ENST00000421017 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000370690 | ENST00000451270 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000394153 | ENST00000332680 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000394153 | ENST00000396024 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000394153 | ENST00000421017 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000394153 | ENST00000451270 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000394155 | ENST00000332680 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000394155 | ENST00000396024 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000394155 | ENST00000421017 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000394155 | ENST00000451270 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000535737 | ENST00000332680 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000535737 | ENST00000396024 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000535737 | ENST00000421017 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000535737 | ENST00000451270 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000543669 | ENST00000332680 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000543669 | ENST00000396024 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000543669 | ENST00000421017 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-3CDS | ENST00000543669 | ENST00000451270 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-5UTR | ENST00000345434 | ENST00000557937 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-5UTR | ENST00000370690 | ENST00000557937 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-5UTR | ENST00000394153 | ENST00000557937 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-5UTR | ENST00000394155 | ENST00000557937 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-5UTR | ENST00000535737 | ENST00000557937 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
5UTR-5UTR | ENST00000543669 | ENST00000557937 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-3CDS | ENST00000370676 | ENST00000332680 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-3CDS | ENST00000370676 | ENST00000396024 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-3CDS | ENST00000370676 | ENST00000421017 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-3CDS | ENST00000370676 | ENST00000451270 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-3CDS | ENST00000370683 | ENST00000332680 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-3CDS | ENST00000370683 | ENST00000396024 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-3CDS | ENST00000370683 | ENST00000421017 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-3CDS | ENST00000370683 | ENST00000451270 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-3CDS | ENST00000477080 | ENST00000332680 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-3CDS | ENST00000477080 | ENST00000396024 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-3CDS | ENST00000477080 | ENST00000421017 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-3CDS | ENST00000477080 | ENST00000451270 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-3CDS | ENST00000539015 | ENST00000332680 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-3CDS | ENST00000539015 | ENST00000396024 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-3CDS | ENST00000539015 | ENST00000421017 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-3CDS | ENST00000539015 | ENST00000451270 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-5UTR | ENST00000370676 | ENST00000557937 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-5UTR | ENST00000370683 | ENST00000557937 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-5UTR | ENST00000477080 | ENST00000557937 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
intron-5UTR | ENST00000539015 | ENST00000557937 | FHL1 | chrX | 135252139 | + | ANXA2 | chr15 | 60656722 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for FHL1-ANXA2 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for FHL1-ANXA2 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:135252139/:60656722) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for FHL1-ANXA2 |
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Fusion Gene PPI Analysis for FHL1-ANXA2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FHL1-ANXA2 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FHL1-ANXA2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FHL1 | C4225159 | REDUCING BODY MYOPATHY, X-LINKED 1B, WITH LATE CHILDHOOD OR ADULT ONSET | 6 | GENOMICS_ENGLAND;UNIPROT |
Hgene | FHL1 | C2678055 | MYOPATHY, X-LINKED, WITH POSTURAL MUSCLE ATROPHY (disorder) | 5 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | FHL1 | C4225423 | REDUCING BODY MYOPATHY, X-LINKED 1A, SEVERE, WITH INFANTILE OR EARLY CHILDHOOD ONSET | 4 | GENOMICS_ENGLAND;UNIPROT |
Hgene | FHL1 | C2678061 | SCAPULOPERONEAL MYOPATHY, X-LINKED DOMINANT | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | FHL1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | FHL1 | C0270970 | Reducing-body myopathy | 1 | ORPHANET |
Hgene | FHL1 | C1135196 | Heart Failure, Diastolic | 1 | CTD_human |
Hgene | FHL1 | C1846010 | URUGUAY FACIOCARDIOMUSCULOSKELETAL SYNDROME | 1 | GENOMICS_ENGLAND |
Tgene | C0001787 | Osteoporosis, Age-Related | 1 | CTD_human | |
Tgene | C0007137 | Squamous cell carcinoma | 1 | CTD_human | |
Tgene | C0019193 | Hepatitis, Toxic | 1 | CTD_human | |
Tgene | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human | |
Tgene | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human | |
Tgene | C0023903 | Liver neoplasms | 1 | CTD_human | |
Tgene | C0024121 | Lung Neoplasms | 1 | CTD_human | |
Tgene | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human | |
Tgene | C0026640 | Mouth Neoplasms | 1 | CTD_human | |
Tgene | C0026998 | Acute Myeloid Leukemia, M1 | 1 | CTD_human | |
Tgene | C0027626 | Neoplasm Invasiveness | 1 | CTD_human | |
Tgene | C0029456 | Osteoporosis | 1 | CTD_human | |
Tgene | C0029459 | Osteoporosis, Senile | 1 | CTD_human | |
Tgene | C0043094 | Weight Gain | 1 | CTD_human | |
Tgene | C0153381 | Malignant neoplasm of mouth | 1 | CTD_human | |
Tgene | C0242379 | Malignant neoplasm of lung | 1 | CTD_human | |
Tgene | C0345904 | Malignant neoplasm of liver | 1 | CTD_human | |
Tgene | C0345967 | Malignant mesothelioma | 1 | CTD_human | |
Tgene | C0751406 | Post-Traumatic Osteoporosis | 1 | CTD_human | |
Tgene | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human | |
Tgene | C1257925 | Mammary Carcinoma, Animal | 1 | CTD_human | |
Tgene | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human | |
Tgene | C1879321 | Acute Myeloid Leukemia (AML-M2) | 1 | CTD_human | |
Tgene | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human | |
Tgene | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human | |
Tgene | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |