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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:COBLL1-FMNL2 (FusionGDB2 ID:HG22837TG114793)

Fusion Gene Summary for COBLL1-FMNL2

check button Fusion gene summary
Fusion gene informationFusion gene name: COBLL1-FMNL2
Fusion gene ID: hg22837tg114793
HgeneTgene
Gene symbol

COBLL1

FMNL2

Gene ID

22837

114793

Gene namecordon-bleu WH2 repeat protein like 1formin like 2
SynonymsCOBLR1FHOD2
Cytomap('COBLL1')('FMNL2')

2q24.3

2q23.3

Type of geneprotein-codingprotein-coding
Descriptioncordon-bleu protein-like 1COBL-like 1formin-like protein 2formin homology 2 domain containing 2formin homology 2 domain-containing protein 2
Modification date2020031320200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000194871, ENST00000342193, 
ENST00000375458, ENST00000392717, 
ENST00000409184, ENST00000491126, 
Fusion gene scores* DoF score11 X 7 X 8=61614 X 15 X 6=1260
# samples 1617
** MAII scorelog2(16/616*10)=-1.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1260*10)=-2.88981708224958
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COBLL1 [Title/Abstract] AND FMNL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCOBLL1(165697666)-FMNL2(153378457), # samples:2
Anticipated loss of major functional domain due to fusion event.COBLL1-FMNL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
COBLL1-FMNL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
COBLL1-FMNL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
COBLL1-FMNL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
COBLL1-FMNL2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across COBLL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across FMNL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A6B8-01ACOBLL1chr2

165697666

-FMNL2chr2

153378457

+


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Fusion Gene ORF analysis for COBLL1-FMNL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000194871ENST00000475377COBLL1chr2

165697666

-FMNL2chr2

153378457

+
5CDS-intronENST00000194871ENST00000497192COBLL1chr2

165697666

-FMNL2chr2

153378457

+
5CDS-intronENST00000342193ENST00000475377COBLL1chr2

165697666

-FMNL2chr2

153378457

+
5CDS-intronENST00000342193ENST00000497192COBLL1chr2

165697666

-FMNL2chr2

153378457

+
5CDS-intronENST00000375458ENST00000475377COBLL1chr2

165697666

-FMNL2chr2

153378457

+
5CDS-intronENST00000375458ENST00000497192COBLL1chr2

165697666

-FMNL2chr2

153378457

+
5CDS-intronENST00000392717ENST00000475377COBLL1chr2

165697666

-FMNL2chr2

153378457

+
5CDS-intronENST00000392717ENST00000497192COBLL1chr2

165697666

-FMNL2chr2

153378457

+
5CDS-intronENST00000409184ENST00000475377COBLL1chr2

165697666

-FMNL2chr2

153378457

+
5CDS-intronENST00000409184ENST00000497192COBLL1chr2

165697666

-FMNL2chr2

153378457

+
5UTR-3CDSENST00000491126ENST00000288670COBLL1chr2

165697666

-FMNL2chr2

153378457

+
5UTR-intronENST00000491126ENST00000475377COBLL1chr2

165697666

-FMNL2chr2

153378457

+
5UTR-intronENST00000491126ENST00000497192COBLL1chr2

165697666

-FMNL2chr2

153378457

+
Frame-shiftENST00000194871ENST00000288670COBLL1chr2

165697666

-FMNL2chr2

153378457

+
Frame-shiftENST00000392717ENST00000288670COBLL1chr2

165697666

-FMNL2chr2

153378457

+
Frame-shiftENST00000409184ENST00000288670COBLL1chr2

165697666

-FMNL2chr2

153378457

+
In-frameENST00000342193ENST00000288670COBLL1chr2

165697666

-FMNL2chr2

153378457

+
In-frameENST00000375458ENST00000288670COBLL1chr2

165697666

-FMNL2chr2

153378457

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375458COBLL1chr2165697666-ENST00000288670FMNL2chr2153378457+535426326934241051
ENST00000342193COBLL1chr2165697666-ENST00000288670FMNL2chr2153378457+534825726334181051

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375458ENST00000288670COBLL1chr2165697666-FMNL2chr2153378457+0.0001940020.999806
ENST00000342193ENST00000288670COBLL1chr2165697666-FMNL2chr2153378457+0.0001909920.9998091

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Fusion Genomic Features for COBLL1-FMNL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
COBLL1chr2165697665-FMNL2chr2153378456+9.27E-080.9999999
COBLL1chr2165697665-FMNL2chr2153378456+9.27E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for COBLL1-FMNL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:165697666/chr2:153378457)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFMNL2chr2:165697666chr2:153378457ENST00000288670026525_603391093.0Compositional biasNote=Pro-rich
TgeneFMNL2chr2:165697666chr2:153378457ENST000002886700261040_1079391093.0DomainDAD
TgeneFMNL2chr2:165697666chr2:153378457ENST00000288670026616_1007391093.0DomainFH2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCOBLL1chr2:165697666chr2:153378457ENST00000342193-1141081_1101131167.0DomainWH2
HgeneCOBLL1chr2:165697666chr2:153378457ENST00000375458-1131081_1101131129.0DomainWH2
HgeneCOBLL1chr2:165697666chr2:153378457ENST00000392717-2151081_1101511205.0DomainWH2
HgeneCOBLL1chr2:165697666chr2:153378457ENST00000409184-2141081_1101511167.0DomainWH2
HgeneCOBLL1chr2:165697666chr2:153378457ENST00000342193-114291_296131167.0MotifNote=KKRRAP 1
HgeneCOBLL1chr2:165697666chr2:153378457ENST00000342193-114360_365131167.0MotifNote=KKRRAP 2
HgeneCOBLL1chr2:165697666chr2:153378457ENST00000375458-113291_296131129.0MotifNote=KKRRAP 1
HgeneCOBLL1chr2:165697666chr2:153378457ENST00000375458-113360_365131129.0MotifNote=KKRRAP 2
HgeneCOBLL1chr2:165697666chr2:153378457ENST00000392717-215291_296511205.0MotifNote=KKRRAP 1
HgeneCOBLL1chr2:165697666chr2:153378457ENST00000392717-215360_365511205.0MotifNote=KKRRAP 2
HgeneCOBLL1chr2:165697666chr2:153378457ENST00000409184-214291_296511167.0MotifNote=KKRRAP 1
HgeneCOBLL1chr2:165697666chr2:153378457ENST00000409184-214360_365511167.0MotifNote=KKRRAP 2
TgeneFMNL2chr2:165697666chr2:153378457ENST0000028867002623_469391093.0DomainGBD/FH3


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Fusion Gene Sequence for COBLL1-FMNL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>17977_17977_1_COBLL1-FMNL2_COBLL1_chr2_165697666_ENST00000342193_FMNL2_chr2_153378457_ENST00000288670_length(transcript)=5348nt_BP=257nt
CGGCGCCCGCGGGCTGGGAGCCGGGGCCCGCAGGTGGAAGCGCACCCGGGAGGCGGGCCGGCCGGGGCTGGAGCGGCTCGGGCGGGCTCT
TGACGCTCAGCCAGCTTCGCTCCGGCCTCGGGAAGGCGCGCGTCCCGCCCTGACCCGCCGGCCTCTCCCACCCCAGCAGTGACGCGCCGC
CTGGGAGCTGGAGCCCGCGCAGCGCCCCGCAGGGCGATGGACGGCCGAACCCCGCGCCCGCAGGACGCCCCAGCCAGAATGCTATGAACC
TACCTCCTGACAAAGCCAGGTTACTGCGGCAGTATGATAATGAGAAAAAATGGGAACTGATTTGTGATCAGGAACGATTCCAGGTGAAGA
ATCCTCCCCATACATACATTCAAAAGCTCAAAGGCTATCTGGATCCAGCTGTAACCAGGAAGAAATTCAGACGGCGTGTTCAAGAATCTA
CACAAGTGCTAAGAGAACTGGAAATTTCTTTGAGAACTAACCACATTGGATGGGTCAGAGAATTTCTGAATGAAGAAAACAAAGGTCTTG
ATGTTCTAGTGGAATATCTCTCATTTGCACAGTACGCGGTAACTTTTGACTTTGAAAGTGTGGAGAGTACTGTGGAGAGCTCGGTGGACA
AATCAAAGCCCTGGAGTAGGTCCATCGAGGACCTGCACAGAGGGAGCAACCTGCCCTCACCTGTGGGCAACAGTGTCTCCCGCTCTGGAA
GACATTCTGCACTGCGATATAATACATTGCCAAGCAGAAGAACTCTGAAAAATTCAAGATTAGTGAGTAAGAAAGATGATGTGCATGTCT
GTATCATGTGTTTACGTGCCATCATGAATTATCAGTATGGTTTCAACATGGTCATGTCTCATCCACACGCTGTCAATGAGATTGCACTAA
GCCTGAACAACAAGAATCCCAGAACAAAAGCCCTTGTCTTAGAACTGTTGGCAGCCGTTTGTCTTGTCAGAGGCGGGCATGAAATCATTT
TATCAGCATTTGATAACTTTAAAGAGGTTTGTGGAGAAAAACAGCGCTTTGAGAAGTTGATGGAACATTTCAGGAATGAAGACAATAACA
TAGATTTTATGGTGGCTTCTATGCAGTTTATTAATATTGTAGTCCATTCAGTAGAAGATATGAATTTCAGAGTTCACCTGCAGTATGAAT
TTACCAAATTAGGCCTGGACGAATACTTGGACAAGCTGAAACACACTGAGAGTGACAAGCTTCAAGTCCAGATCCAGGCTTACCTGGACA
ATGTTTTTGATGTAGGAGCTCTACTGGAAGATGCTGAAACTAAGAATGCTGCCTTGGAGAGGGTGGAAGAACTGGAAGAAAACATTTCTC
ATTTATCTGAAAAACTGCAAGACACAGAGAATGAAGCCATGTCCAAGATTGTGGAACTGGAAAAGCAACTCATGCAGAGGAACAAGGAGC
TGGATGTCGTTCGGGAAATCTACAAAGATGCAAATACTCAAGTTCACACATTAAGAAAAATGGTCAAAGAAAAAGAAGAAGCAATTCAAA
GACAGTCTACCCTGGAAAAAAAGATTCATGAGCTAGAGAAACAAGGGACCATTAAAATTCAGAAGAAAGGGGATGGGGATATCGCCATAC
TGCCAGTTGTGGCTTCTGGCACATTGTCCATGGGGTCAGAAGTGGTAGCAGGTAACTCTGTGGGACCCACAATGGGGGCCGCTTCCTCAG
GACCCTTGCCCCCTCCTCCACCACCACTGCCTCCCTCATCAGACACACCTGAAACAGTGCAAAATGGTCCAGTAACACCACCTATGCCAC
CGCCGCCGCCGCCCCCTCCTCCACCTCCTCCTCCCCCACCGCCCCCTCCGCCTCCTCCTCTCCCAGGCCCTGCAGCTGAGACTGTACCAG
CTCCTCCCTTAGCACCTCCCCTTCCCTCTGCACCTCCGCTGCCTGGAACATCTTCACCCACAGTGGTTTTCAACTCAGGATTAGCAGCTG
TGAAAATTAAGAAGCCAATCAAGACGAAGTTCAGAATGCCAGTGTTTAACTGGGTTGCTCTGAAGCCCAATCAGATCAATGGCACAGTCT
TCAATGAAATTGATGATGAGCGAATTCTGGAGGATTTAAATGTGGATGAATTTGAGGAAATATTCAAGACAAAAGCCCAAGGACCTGCCA
TTGATCTTTCTTCAAGCAAACAGAAGATACCACAGAAGGGATCAAACAAAGTGACATTACTAGAAGCAAACAGGGCCAAAAATCTTGCCA
TAACTTTAAGGAAAGCTGGAAAGACTGCTGATGAAATATGTAAAGCTATTCATGTATTTGACTTGAAGACACTGCCTGTGGACTTTGTGG
AATGCTTGATGCGGTTCCTACCAACTGAGAATGAAGTGAAAGTGCTTCGGCTCTACGAGCGGGAAAGGAAGCCTCTGGAAAACTTGTCAG
ATGAAGATCGGTTCATGATGCAGTTTAGTAAAATCGAGAGGCTCATGCAGAAGATGACCATCATGGCCTTCATTGGGAACTTTGCTGAAA
GCATTCAGATGCTGACTCCTCAACTACATGCGATTATAGCAGCATCTGTCTCTATAAAGTCGTCCCAAAAACTCAAGAAAATTCTGGAGA
TCATCTTAGCCCTTGGAAACTACATGAATAGCAGTAAAAGAGGAGCAGTTTATGGATTTAAACTTCAGAGTTTAGATCTGCTCTTAGATA
CAAAGTCAACAGACAGAAAGCAAACACTGTTGCACTATATATCCAATGTGGTGAAAGAAAAATATCACCAAGTGTCCCTGTTTTATAATG
AGCTTCATTATGTGGAAAAAGCTGCTGCAGTCTCCCTTGAGAATGTTTTGCTGGATGTCAAGGAGCTCCAGAGGGGAATGGACTTGACCA
AGAGAGAGTACACCATGCATGACCATAACACGCTGCTGAAGGAGTTCATCCTCAACAATGAGGGGAAGCTGAAGAAGCTGCAGGATGATG
CCAAGATCGCACAGGATGCCTTTGATGATGTTGTGAAGTATTTTGGAGAAAACCCCAAGACAACACCACCCTCTGTCTTCTTTCCTGTCT
TTGTCCGGTTTGTGAAAGCATATAAGCAAGCAGAAGAGGAAAATGAGCTGAGGAAAAAGCAGGAACAAGCTCTCATGGAAAAACTCCTAG
AGCAAGAAGCTCTGATGGAGCAGCAGGATCCAAAGTCTCCTTCTCATAAATCAAAGAGGCAGCAGCAAGAGTTAATTGCAGAATTAAGAA
GACGACAAGTTAAAGATAACAGACATGTATATGAGGGAAAAGATGGTGCCATTGAAGATATTATCACAGATCTTAGAAACCAACCATACA
GACGAGCCGATGCGGTGAGGAGAAGCGTCAGGCGGCGCTTTGATGATCAGAACTTGCGTTCTGTTAATGGTGCCGAAATAACAATGTGAA
CCTGAGACTGGCCTGCATGAATACAGGGTGTGCGTGAATGAAACTGCCCACATGAACTTTATGTGCTACGATTTAACTGCAGCCTTGAAC
ACACACAAAAATATTCTTAAGGGCTCAGATTTAGCAAACACGGAAGAATTTTAAAATGAGCTCTCCTTTCAACCCTTGTTAACAAGTGCC
TAAAAATGGAAGTACCTGTTCAGATTAATCAAAGCAATAGGATTTGATTTGATTAGGTATCTTTTTACACCAGTATGTTATTTTTAACCA
AAATGTAAAGTTCTTATTAAACTCATTACCTGCCATTGTGATTGTCCCATCATGGCCCACCTGGTTTCCTGATGTTGTAAATAACATCAA
TGCATCTGCTGTGGGTCCTTTGCTGAGATGTCTTCGAAGGAATTTTGTTTTAGCCATATCCATCAACTTTGTATTTTACTTGCAATTTGG
AAGAAGGAAAGTCACATGATGAAACTCCTTTTGTCTATAACCAGGCCCTGGCAAAGTGCAAACAGGATGCAACTGCAGTGGCACAAAGGT
CACTCAATCCTTTGTTTCCAGTTTCACATTCTACTACTTCTGCGCTAGAGAACGATGCTCTGTGAGAGGCATTCACTAGTATGAATGTGG
GGATATAGTGTATAAGACTTATTTGCAGTACTGTGTTCTTCAGCTAGAGGCAGCTTTTTAAATAATGCAAGTGTATTTATTAGCATTAAA
ATTAACATCTCAGTAATCAGCATTAGCATTTCTGAGGACCATTATTAATTCTGAGAACAGAAATTGGTGCCTTGCAAGGAAGTTTACTAG
CTCTATCAACAAGCATTCAAGGTTACATCTGCTAGCAGAGTAGTGTTAGGAACCTGGCCTTACTCTCCTCTGACAATCGCAATTTTTTCT
TATTTTTTATAAATTCAAGAAGATACACTTGGCATCGTGTATCGAGGCTAAGTTTTTCATGCATTTCCCAGACTACTTATGGAGAATTGC
AGTTTAAGTTGCTGAAAAGTATTAACATGGTATTAAGCTTAAATAATACGTAATGGGACTAGATGGCCCACTAAGCCACTGTTATTTTCC
TTCCTCTCTGGCAGGGCACTTGATCCATTCCAAAGTCAAAAACTGGACTGAAGCTAAATTTGTACTTTTCATAATATACATTCTGCTTCT
GGCTTATCTTCTTGGTACATCAATATATTAATTGTAAAGTTTATTGTATAGTATTTAACCGCTGAAGTTCCTATTTTATGTTGTGCTTAT
GTGAACCCCTTGGTGAAGGTCCCTTTTCCTTGGATGTGTAGTTATATGATCTTTTTAAATGTACAGATATTTTGCTATAAAATCGGTGCA
GTTTTTTATGGTTTTTACACTTCTCTTTAATTCCCACCTAAGCCTCTGGGTAATATTGTAAATATTGTTTTAAAATGCATCAGCCTATGC
TATACAATCTGAATGTTATTTTAACTTATAGTTTTTTTTAATATATATATTTAACTATAAGGACAGTTTAGGGAACAAGTTACCTACCAC
ATTTCACTTTAGTGTACCTATTTACAGAAAGATTAAACTGCCACCTGCGGGCACATTCCCATAAATGTGTACTTTACTTTAAAAAGAACA
TGCCACGATTTTGTCTTTCTGTGGACTCAACATTCACTTCGATTAAAAATAGCAATTTGACCAAGTTGGACTTCCACTACAAAGCAGCTG
TTTTCCAAAGTTCAATGCTGACATATATGTATATTAAAATAATTGCCTATTTATTAATCTACAAATAGACAACGTTGGCATGTTCTTTTC
TGTTTGTCTATTAATGGGCCTGCTTCTTAGCAATATTAGAATGTTTTATAAAAGCAATTCATGTTACTTTTCTGGTCTTTTCATGGCATA
TGAGCAAATAATAAACTATTTACACTACTATTCTGTAA

>17977_17977_1_COBLL1-FMNL2_COBLL1_chr2_165697666_ENST00000342193_FMNL2_chr2_153378457_ENST00000288670_length(amino acids)=1051AA_BP=0
MNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENK
GLDVLVEYLSFAQYAVTFDFESVESTVESSVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDV
HVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNED
NNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEEN
ISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDI
AILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAET
VPAPPLAPPLPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQG
PAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLEN
LSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLL
LDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFILNNEGKLKKLQ
DDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDPKSPSHKSKRQQQELIAE
LRRRQVKDNRHVYEGKDGAIEDIITDLRNQPYRRADAVRRSVRRRFDDQNLRSVNGAEITM

--------------------------------------------------------------
>17977_17977_2_COBLL1-FMNL2_COBLL1_chr2_165697666_ENST00000375458_FMNL2_chr2_153378457_ENST00000288670_length(transcript)=5354nt_BP=263nt
CGGCGGCGGCGCCCGCGGGCTGGGAGCCGGGGCCCGCAGGTGGAAGCGCACCCGGGAGGCGGGCCGGCCGGGGCTGGAGCGGCTCGGGCG
GGCTCTTGACGCTCAGCCAGCTTCGCTCCGGCCTCGGGAAGGCGCGCGTCCCGCCCTGACCCGCCGGCCTCTCCCACCCCAGCAGTGACG
CGCCGCCTGGGAGCTGGAGCCCGCGCAGCGCCCCGCAGGGCGATGGACGGCCGAACCCCGCGCCCGCAGGACGCCCCAGCCAGAATGCTA
TGAACCTACCTCCTGACAAAGCCAGGTTACTGCGGCAGTATGATAATGAGAAAAAATGGGAACTGATTTGTGATCAGGAACGATTCCAGG
TGAAGAATCCTCCCCATACATACATTCAAAAGCTCAAAGGCTATCTGGATCCAGCTGTAACCAGGAAGAAATTCAGACGGCGTGTTCAAG
AATCTACACAAGTGCTAAGAGAACTGGAAATTTCTTTGAGAACTAACCACATTGGATGGGTCAGAGAATTTCTGAATGAAGAAAACAAAG
GTCTTGATGTTCTAGTGGAATATCTCTCATTTGCACAGTACGCGGTAACTTTTGACTTTGAAAGTGTGGAGAGTACTGTGGAGAGCTCGG
TGGACAAATCAAAGCCCTGGAGTAGGTCCATCGAGGACCTGCACAGAGGGAGCAACCTGCCCTCACCTGTGGGCAACAGTGTCTCCCGCT
CTGGAAGACATTCTGCACTGCGATATAATACATTGCCAAGCAGAAGAACTCTGAAAAATTCAAGATTAGTGAGTAAGAAAGATGATGTGC
ATGTCTGTATCATGTGTTTACGTGCCATCATGAATTATCAGTATGGTTTCAACATGGTCATGTCTCATCCACACGCTGTCAATGAGATTG
CACTAAGCCTGAACAACAAGAATCCCAGAACAAAAGCCCTTGTCTTAGAACTGTTGGCAGCCGTTTGTCTTGTCAGAGGCGGGCATGAAA
TCATTTTATCAGCATTTGATAACTTTAAAGAGGTTTGTGGAGAAAAACAGCGCTTTGAGAAGTTGATGGAACATTTCAGGAATGAAGACA
ATAACATAGATTTTATGGTGGCTTCTATGCAGTTTATTAATATTGTAGTCCATTCAGTAGAAGATATGAATTTCAGAGTTCACCTGCAGT
ATGAATTTACCAAATTAGGCCTGGACGAATACTTGGACAAGCTGAAACACACTGAGAGTGACAAGCTTCAAGTCCAGATCCAGGCTTACC
TGGACAATGTTTTTGATGTAGGAGCTCTACTGGAAGATGCTGAAACTAAGAATGCTGCCTTGGAGAGGGTGGAAGAACTGGAAGAAAACA
TTTCTCATTTATCTGAAAAACTGCAAGACACAGAGAATGAAGCCATGTCCAAGATTGTGGAACTGGAAAAGCAACTCATGCAGAGGAACA
AGGAGCTGGATGTCGTTCGGGAAATCTACAAAGATGCAAATACTCAAGTTCACACATTAAGAAAAATGGTCAAAGAAAAAGAAGAAGCAA
TTCAAAGACAGTCTACCCTGGAAAAAAAGATTCATGAGCTAGAGAAACAAGGGACCATTAAAATTCAGAAGAAAGGGGATGGGGATATCG
CCATACTGCCAGTTGTGGCTTCTGGCACATTGTCCATGGGGTCAGAAGTGGTAGCAGGTAACTCTGTGGGACCCACAATGGGGGCCGCTT
CCTCAGGACCCTTGCCCCCTCCTCCACCACCACTGCCTCCCTCATCAGACACACCTGAAACAGTGCAAAATGGTCCAGTAACACCACCTA
TGCCACCGCCGCCGCCGCCCCCTCCTCCACCTCCTCCTCCCCCACCGCCCCCTCCGCCTCCTCCTCTCCCAGGCCCTGCAGCTGAGACTG
TACCAGCTCCTCCCTTAGCACCTCCCCTTCCCTCTGCACCTCCGCTGCCTGGAACATCTTCACCCACAGTGGTTTTCAACTCAGGATTAG
CAGCTGTGAAAATTAAGAAGCCAATCAAGACGAAGTTCAGAATGCCAGTGTTTAACTGGGTTGCTCTGAAGCCCAATCAGATCAATGGCA
CAGTCTTCAATGAAATTGATGATGAGCGAATTCTGGAGGATTTAAATGTGGATGAATTTGAGGAAATATTCAAGACAAAAGCCCAAGGAC
CTGCCATTGATCTTTCTTCAAGCAAACAGAAGATACCACAGAAGGGATCAAACAAAGTGACATTACTAGAAGCAAACAGGGCCAAAAATC
TTGCCATAACTTTAAGGAAAGCTGGAAAGACTGCTGATGAAATATGTAAAGCTATTCATGTATTTGACTTGAAGACACTGCCTGTGGACT
TTGTGGAATGCTTGATGCGGTTCCTACCAACTGAGAATGAAGTGAAAGTGCTTCGGCTCTACGAGCGGGAAAGGAAGCCTCTGGAAAACT
TGTCAGATGAAGATCGGTTCATGATGCAGTTTAGTAAAATCGAGAGGCTCATGCAGAAGATGACCATCATGGCCTTCATTGGGAACTTTG
CTGAAAGCATTCAGATGCTGACTCCTCAACTACATGCGATTATAGCAGCATCTGTCTCTATAAAGTCGTCCCAAAAACTCAAGAAAATTC
TGGAGATCATCTTAGCCCTTGGAAACTACATGAATAGCAGTAAAAGAGGAGCAGTTTATGGATTTAAACTTCAGAGTTTAGATCTGCTCT
TAGATACAAAGTCAACAGACAGAAAGCAAACACTGTTGCACTATATATCCAATGTGGTGAAAGAAAAATATCACCAAGTGTCCCTGTTTT
ATAATGAGCTTCATTATGTGGAAAAAGCTGCTGCAGTCTCCCTTGAGAATGTTTTGCTGGATGTCAAGGAGCTCCAGAGGGGAATGGACT
TGACCAAGAGAGAGTACACCATGCATGACCATAACACGCTGCTGAAGGAGTTCATCCTCAACAATGAGGGGAAGCTGAAGAAGCTGCAGG
ATGATGCCAAGATCGCACAGGATGCCTTTGATGATGTTGTGAAGTATTTTGGAGAAAACCCCAAGACAACACCACCCTCTGTCTTCTTTC
CTGTCTTTGTCCGGTTTGTGAAAGCATATAAGCAAGCAGAAGAGGAAAATGAGCTGAGGAAAAAGCAGGAACAAGCTCTCATGGAAAAAC
TCCTAGAGCAAGAAGCTCTGATGGAGCAGCAGGATCCAAAGTCTCCTTCTCATAAATCAAAGAGGCAGCAGCAAGAGTTAATTGCAGAAT
TAAGAAGACGACAAGTTAAAGATAACAGACATGTATATGAGGGAAAAGATGGTGCCATTGAAGATATTATCACAGATCTTAGAAACCAAC
CATACAGACGAGCCGATGCGGTGAGGAGAAGCGTCAGGCGGCGCTTTGATGATCAGAACTTGCGTTCTGTTAATGGTGCCGAAATAACAA
TGTGAACCTGAGACTGGCCTGCATGAATACAGGGTGTGCGTGAATGAAACTGCCCACATGAACTTTATGTGCTACGATTTAACTGCAGCC
TTGAACACACACAAAAATATTCTTAAGGGCTCAGATTTAGCAAACACGGAAGAATTTTAAAATGAGCTCTCCTTTCAACCCTTGTTAACA
AGTGCCTAAAAATGGAAGTACCTGTTCAGATTAATCAAAGCAATAGGATTTGATTTGATTAGGTATCTTTTTACACCAGTATGTTATTTT
TAACCAAAATGTAAAGTTCTTATTAAACTCATTACCTGCCATTGTGATTGTCCCATCATGGCCCACCTGGTTTCCTGATGTTGTAAATAA
CATCAATGCATCTGCTGTGGGTCCTTTGCTGAGATGTCTTCGAAGGAATTTTGTTTTAGCCATATCCATCAACTTTGTATTTTACTTGCA
ATTTGGAAGAAGGAAAGTCACATGATGAAACTCCTTTTGTCTATAACCAGGCCCTGGCAAAGTGCAAACAGGATGCAACTGCAGTGGCAC
AAAGGTCACTCAATCCTTTGTTTCCAGTTTCACATTCTACTACTTCTGCGCTAGAGAACGATGCTCTGTGAGAGGCATTCACTAGTATGA
ATGTGGGGATATAGTGTATAAGACTTATTTGCAGTACTGTGTTCTTCAGCTAGAGGCAGCTTTTTAAATAATGCAAGTGTATTTATTAGC
ATTAAAATTAACATCTCAGTAATCAGCATTAGCATTTCTGAGGACCATTATTAATTCTGAGAACAGAAATTGGTGCCTTGCAAGGAAGTT
TACTAGCTCTATCAACAAGCATTCAAGGTTACATCTGCTAGCAGAGTAGTGTTAGGAACCTGGCCTTACTCTCCTCTGACAATCGCAATT
TTTTCTTATTTTTTATAAATTCAAGAAGATACACTTGGCATCGTGTATCGAGGCTAAGTTTTTCATGCATTTCCCAGACTACTTATGGAG
AATTGCAGTTTAAGTTGCTGAAAAGTATTAACATGGTATTAAGCTTAAATAATACGTAATGGGACTAGATGGCCCACTAAGCCACTGTTA
TTTTCCTTCCTCTCTGGCAGGGCACTTGATCCATTCCAAAGTCAAAAACTGGACTGAAGCTAAATTTGTACTTTTCATAATATACATTCT
GCTTCTGGCTTATCTTCTTGGTACATCAATATATTAATTGTAAAGTTTATTGTATAGTATTTAACCGCTGAAGTTCCTATTTTATGTTGT
GCTTATGTGAACCCCTTGGTGAAGGTCCCTTTTCCTTGGATGTGTAGTTATATGATCTTTTTAAATGTACAGATATTTTGCTATAAAATC
GGTGCAGTTTTTTATGGTTTTTACACTTCTCTTTAATTCCCACCTAAGCCTCTGGGTAATATTGTAAATATTGTTTTAAAATGCATCAGC
CTATGCTATACAATCTGAATGTTATTTTAACTTATAGTTTTTTTTAATATATATATTTAACTATAAGGACAGTTTAGGGAACAAGTTACC
TACCACATTTCACTTTAGTGTACCTATTTACAGAAAGATTAAACTGCCACCTGCGGGCACATTCCCATAAATGTGTACTTTACTTTAAAA
AGAACATGCCACGATTTTGTCTTTCTGTGGACTCAACATTCACTTCGATTAAAAATAGCAATTTGACCAAGTTGGACTTCCACTACAAAG
CAGCTGTTTTCCAAAGTTCAATGCTGACATATATGTATATTAAAATAATTGCCTATTTATTAATCTACAAATAGACAACGTTGGCATGTT
CTTTTCTGTTTGTCTATTAATGGGCCTGCTTCTTAGCAATATTAGAATGTTTTATAAAAGCAATTCATGTTACTTTTCTGGTCTTTTCAT
GGCATATGAGCAAATAATAAACTATTTACACTACTATTCTGTAA

>17977_17977_2_COBLL1-FMNL2_COBLL1_chr2_165697666_ENST00000375458_FMNL2_chr2_153378457_ENST00000288670_length(amino acids)=1051AA_BP=0
MNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENK
GLDVLVEYLSFAQYAVTFDFESVESTVESSVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDV
HVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNED
NNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEEN
ISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDI
AILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAET
VPAPPLAPPLPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQG
PAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLEN
LSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLL
LDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFILNNEGKLKKLQ
DDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDPKSPSHKSKRQQQELIAE
LRRRQVKDNRHVYEGKDGAIEDIITDLRNQPYRRADAVRRSVRRRFDDQNLRSVNGAEITM

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Fusion Gene PPI Analysis for COBLL1-FMNL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for COBLL1-FMNL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for COBLL1-FMNL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource