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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:COBLL1-SMYD3 (FusionGDB2 ID:HG22837TG64754)

Fusion Gene Summary for COBLL1-SMYD3

check button Fusion gene summary
Fusion gene informationFusion gene name: COBLL1-SMYD3
Fusion gene ID: hg22837tg64754
HgeneTgene
Gene symbol

COBLL1

SMYD3

Gene ID

22837

64754

Gene namecordon-bleu WH2 repeat protein like 1SET and MYND domain containing 3
SynonymsCOBLR1KMT3E|ZMYND1|ZNFN3A1|bA74P14.1
Cytomap('COBLL1')('SMYD3')

2q24.3

1q44

Type of geneprotein-codingprotein-coding
Descriptioncordon-bleu protein-like 1COBL-like 1histone-lysine N-methyltransferase SMYD3SET and MYND domain-containing protein 3bA74P14.1 (novel protein)zinc finger MYND domain-containing protein 1zinc finger protein, subfamily 3A (MYND domain containing), 1zinc finger, MYND domain containing 1
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000194871, ENST00000342193, 
ENST00000375458, ENST00000392717, 
ENST00000409184, ENST00000491126, 
Fusion gene scores* DoF score11 X 7 X 8=61629 X 14 X 17=6902
# samples 1647
** MAII scorelog2(16/616*10)=-1.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(47/6902*10)=-3.87628181187052
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COBLL1 [Title/Abstract] AND SMYD3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCOBLL1(165697666)-SMYD3(246093239), # samples:2
Anticipated loss of major functional domain due to fusion event.COBLL1-SMYD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
COBLL1-SMYD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
COBLL1-SMYD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
COBLL1-SMYD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
COBLL1-SMYD3 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
COBLL1-SMYD3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across COBLL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SMYD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-22-5474-01ACOBLL1chr2

165697666

-SMYD3chr1

246093239

-


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Fusion Gene ORF analysis for COBLL1-SMYD3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000194871ENST00000366517COBLL1chr2

165697666

-SMYD3chr1

246093239

-
5CDS-5UTRENST00000342193ENST00000366517COBLL1chr2

165697666

-SMYD3chr1

246093239

-
5CDS-5UTRENST00000375458ENST00000366517COBLL1chr2

165697666

-SMYD3chr1

246093239

-
5CDS-5UTRENST00000392717ENST00000366517COBLL1chr2

165697666

-SMYD3chr1

246093239

-
5CDS-5UTRENST00000409184ENST00000366517COBLL1chr2

165697666

-SMYD3chr1

246093239

-
5CDS-intronENST00000194871ENST00000403792COBLL1chr2

165697666

-SMYD3chr1

246093239

-
5CDS-intronENST00000342193ENST00000403792COBLL1chr2

165697666

-SMYD3chr1

246093239

-
5CDS-intronENST00000375458ENST00000403792COBLL1chr2

165697666

-SMYD3chr1

246093239

-
5CDS-intronENST00000392717ENST00000403792COBLL1chr2

165697666

-SMYD3chr1

246093239

-
5CDS-intronENST00000409184ENST00000403792COBLL1chr2

165697666

-SMYD3chr1

246093239

-
5UTR-3CDSENST00000491126ENST00000388985COBLL1chr2

165697666

-SMYD3chr1

246093239

-
5UTR-3CDSENST00000491126ENST00000490107COBLL1chr2

165697666

-SMYD3chr1

246093239

-
5UTR-3CDSENST00000491126ENST00000541742COBLL1chr2

165697666

-SMYD3chr1

246093239

-
5UTR-5UTRENST00000491126ENST00000366517COBLL1chr2

165697666

-SMYD3chr1

246093239

-
5UTR-intronENST00000491126ENST00000403792COBLL1chr2

165697666

-SMYD3chr1

246093239

-
Frame-shiftENST00000194871ENST00000388985COBLL1chr2

165697666

-SMYD3chr1

246093239

-
Frame-shiftENST00000194871ENST00000490107COBLL1chr2

165697666

-SMYD3chr1

246093239

-
Frame-shiftENST00000194871ENST00000541742COBLL1chr2

165697666

-SMYD3chr1

246093239

-
Frame-shiftENST00000392717ENST00000388985COBLL1chr2

165697666

-SMYD3chr1

246093239

-
Frame-shiftENST00000392717ENST00000490107COBLL1chr2

165697666

-SMYD3chr1

246093239

-
Frame-shiftENST00000392717ENST00000541742COBLL1chr2

165697666

-SMYD3chr1

246093239

-
Frame-shiftENST00000409184ENST00000388985COBLL1chr2

165697666

-SMYD3chr1

246093239

-
Frame-shiftENST00000409184ENST00000490107COBLL1chr2

165697666

-SMYD3chr1

246093239

-
Frame-shiftENST00000409184ENST00000541742COBLL1chr2

165697666

-SMYD3chr1

246093239

-
In-frameENST00000342193ENST00000388985COBLL1chr2

165697666

-SMYD3chr1

246093239

-
In-frameENST00000342193ENST00000490107COBLL1chr2

165697666

-SMYD3chr1

246093239

-
In-frameENST00000342193ENST00000541742COBLL1chr2

165697666

-SMYD3chr1

246093239

-
In-frameENST00000375458ENST00000388985COBLL1chr2

165697666

-SMYD3chr1

246093239

-
In-frameENST00000375458ENST00000490107COBLL1chr2

165697666

-SMYD3chr1

246093239

-
In-frameENST00000375458ENST00000541742COBLL1chr2

165697666

-SMYD3chr1

246093239

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375458COBLL1chr2165697666-ENST00000541742SMYD3chr1246093239-12422632991018239
ENST00000375458COBLL1chr2165697666-ENST00000490107SMYD3chr1246093239-12402632991018239
ENST00000375458COBLL1chr2165697666-ENST00000388985SMYD3chr1246093239-10192632991018240
ENST00000342193COBLL1chr2165697666-ENST00000541742SMYD3chr1246093239-12362572931012239
ENST00000342193COBLL1chr2165697666-ENST00000490107SMYD3chr1246093239-12342572931012239
ENST00000342193COBLL1chr2165697666-ENST00000388985SMYD3chr1246093239-10132572931012240

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375458ENST00000541742COBLL1chr2165697666-SMYD3chr1246093239-0.0019619570.9980381
ENST00000375458ENST00000490107COBLL1chr2165697666-SMYD3chr1246093239-0.0020118950.9979881
ENST00000375458ENST00000388985COBLL1chr2165697666-SMYD3chr1246093239-0.0023188160.99768114
ENST00000342193ENST00000541742COBLL1chr2165697666-SMYD3chr1246093239-0.0020588690.9979411
ENST00000342193ENST00000490107COBLL1chr2165697666-SMYD3chr1246093239-0.0021137350.99788624
ENST00000342193ENST00000388985COBLL1chr2165697666-SMYD3chr1246093239-0.0025123670.99748766

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Fusion Genomic Features for COBLL1-SMYD3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for COBLL1-SMYD3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:165697666/chr1:246093239)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSMYD3chr2:165697666chr1:246093239ENST00000388985412205_206177429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr2:165697666chr1:246093239ENST00000490107412205_206118370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr2:165697666chr1:246093239ENST00000541742412205_206118370.0RegionS-adenosyl-L-methionine binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCOBLL1chr2:165697666chr1:246093239ENST00000342193-1141081_1101131167.0DomainWH2
HgeneCOBLL1chr2:165697666chr1:246093239ENST00000375458-1131081_1101131129.0DomainWH2
HgeneCOBLL1chr2:165697666chr1:246093239ENST00000392717-2151081_1101511205.0DomainWH2
HgeneCOBLL1chr2:165697666chr1:246093239ENST00000409184-2141081_1101511167.0DomainWH2
HgeneCOBLL1chr2:165697666chr1:246093239ENST00000342193-114291_296131167.0MotifNote=KKRRAP 1
HgeneCOBLL1chr2:165697666chr1:246093239ENST00000342193-114360_365131167.0MotifNote=KKRRAP 2
HgeneCOBLL1chr2:165697666chr1:246093239ENST00000375458-113291_296131129.0MotifNote=KKRRAP 1
HgeneCOBLL1chr2:165697666chr1:246093239ENST00000375458-113360_365131129.0MotifNote=KKRRAP 2
HgeneCOBLL1chr2:165697666chr1:246093239ENST00000392717-215291_296511205.0MotifNote=KKRRAP 1
HgeneCOBLL1chr2:165697666chr1:246093239ENST00000392717-215360_365511205.0MotifNote=KKRRAP 2
HgeneCOBLL1chr2:165697666chr1:246093239ENST00000409184-214291_296511167.0MotifNote=KKRRAP 1
HgeneCOBLL1chr2:165697666chr1:246093239ENST00000409184-214360_365511167.0MotifNote=KKRRAP 2
TgeneSMYD3chr2:165697666chr1:246093239ENST000003889854124_240177429.0DomainSET
TgeneSMYD3chr2:165697666chr1:246093239ENST000004901074124_240118370.0DomainSET
TgeneSMYD3chr2:165697666chr1:246093239ENST000005417424124_240118370.0DomainSET
TgeneSMYD3chr2:165697666chr1:246093239ENST0000038898541214_16177429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr2:165697666chr1:246093239ENST0000049010741214_16118370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr2:165697666chr1:246093239ENST0000054174241214_16118370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr2:165697666chr1:246093239ENST0000038898541249_87177429.0Zinc fingerMYND-type
TgeneSMYD3chr2:165697666chr1:246093239ENST0000049010741249_87118370.0Zinc fingerMYND-type
TgeneSMYD3chr2:165697666chr1:246093239ENST0000054174241249_87118370.0Zinc fingerMYND-type


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Fusion Gene Sequence for COBLL1-SMYD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>17985_17985_1_COBLL1-SMYD3_COBLL1_chr2_165697666_ENST00000342193_SMYD3_chr1_246093239_ENST00000388985_length(transcript)=1013nt_BP=257nt
CGGCGCCCGCGGGCTGGGAGCCGGGGCCCGCAGGTGGAAGCGCACCCGGGAGGCGGGCCGGCCGGGGCTGGAGCGGCTCGGGCGGGCTCT
TGACGCTCAGCCAGCTTCGCTCCGGCCTCGGGAAGGCGCGCGTCCCGCCCTGACCCGCCGGCCTCTCCCACCCCAGCAGTGACGCGCCGC
CTGGGAGCTGGAGCCCGCGCAGCGCCCCGCAGGGCGATGGACGGCCGAACCCCGCGCCCGCAGGACGCCCCAGCCAGGTGATCTGCAACT
CTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACT
GTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATA
TGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGG
ATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGT
GGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCG
ACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTT
TCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGA
ATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCG
ACGCCAACATCAGAGCATCCTAA

>17985_17985_1_COBLL1-SMYD3_COBLL1_chr2_165697666_ENST00000342193_SMYD3_chr1_246093239_ENST00000388985_length(amino acids)=240AA_BP=
MQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGD
EQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVR
GVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRASX

--------------------------------------------------------------
>17985_17985_2_COBLL1-SMYD3_COBLL1_chr2_165697666_ENST00000342193_SMYD3_chr1_246093239_ENST00000490107_length(transcript)=1234nt_BP=257nt
CGGCGCCCGCGGGCTGGGAGCCGGGGCCCGCAGGTGGAAGCGCACCCGGGAGGCGGGCCGGCCGGGGCTGGAGCGGCTCGGGCGGGCTCT
TGACGCTCAGCCAGCTTCGCTCCGGCCTCGGGAAGGCGCGCGTCCCGCCCTGACCCGCCGGCCTCTCCCACCCCAGCAGTGACGCGCCGC
CTGGGAGCTGGAGCCCGCGCAGCGCCCCGCAGGGCGATGGACGGCCGAACCCCGCGCCCGCAGGACGCCCCAGCCAGGTGATCTGCAACT
CTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACT
GTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATA
TGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGG
ATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGT
GGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCG
ACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTT
TCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGA
ATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCG
ACGCCAACATCAGAGCATCCTAAGGGAACGCAGTCAGAGGGAAATACGGCGTGTGTCTTTGTTGAATGCCTTATTGAGGTCACACACTCT
ATGCTTTGTTAGCTGTGTGAACCTCTCCTATTGGAAATTCTGTTCCGTGTTTGTGTAGGTAAATAAAGGCAGACATGGTTTGCAAACCAC
AAGAATCATTAGTTGTAGAGAAGCACGATTATAATAAATTCAAAACATTTGGTTGAGGATGCCA

>17985_17985_2_COBLL1-SMYD3_COBLL1_chr2_165697666_ENST00000342193_SMYD3_chr1_246093239_ENST00000490107_length(amino acids)=239AA_BP=
MQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGD
EQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVR
GVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS

--------------------------------------------------------------
>17985_17985_3_COBLL1-SMYD3_COBLL1_chr2_165697666_ENST00000342193_SMYD3_chr1_246093239_ENST00000541742_length(transcript)=1236nt_BP=257nt
CGGCGCCCGCGGGCTGGGAGCCGGGGCCCGCAGGTGGAAGCGCACCCGGGAGGCGGGCCGGCCGGGGCTGGAGCGGCTCGGGCGGGCTCT
TGACGCTCAGCCAGCTTCGCTCCGGCCTCGGGAAGGCGCGCGTCCCGCCCTGACCCGCCGGCCTCTCCCACCCCAGCAGTGACGCGCCGC
CTGGGAGCTGGAGCCCGCGCAGCGCCCCGCAGGGCGATGGACGGCCGAACCCCGCGCCCGCAGGACGCCCCAGCCAGGTGATCTGCAACT
CTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACT
GTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATA
TGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGG
ATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGT
GGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCG
ACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTT
TCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGA
ATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAGAATGCG
ACGCCAACATCAGAGCATCCTAAGGGAACGCAGTCAGAGGGAAATACGGCGTGTGTCTTTGTTGAATGCCTTATTGAGGTCACACACTCT
ATGCTTTGTTAGCTGTGTGAACCTCTCCTATTGGAAATTCTGTTCCGTGTTTGTGTAGGTAAATAAAGGCAGACATGGTTTGCAAACCAC
AAGAATCATTAGTTGTAGAGAAGCACGATTATAATAAATTCAAAACATTTGGTTGAGGATGCCATC

>17985_17985_3_COBLL1-SMYD3_COBLL1_chr2_165697666_ENST00000342193_SMYD3_chr1_246093239_ENST00000541742_length(amino acids)=239AA_BP=
MQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGD
EQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVR
GVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS

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>17985_17985_4_COBLL1-SMYD3_COBLL1_chr2_165697666_ENST00000375458_SMYD3_chr1_246093239_ENST00000388985_length(transcript)=1019nt_BP=263nt
CGGCGGCGGCGCCCGCGGGCTGGGAGCCGGGGCCCGCAGGTGGAAGCGCACCCGGGAGGCGGGCCGGCCGGGGCTGGAGCGGCTCGGGCG
GGCTCTTGACGCTCAGCCAGCTTCGCTCCGGCCTCGGGAAGGCGCGCGTCCCGCCCTGACCCGCCGGCCTCTCCCACCCCAGCAGTGACG
CGCCGCCTGGGAGCTGGAGCCCGCGCAGCGCCCCGCAGGGCGATGGACGGCCGAACCCCGCGCCCGCAGGACGCCCCAGCCAGGTGATCT
GCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACC
CCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACC
TGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGG
ACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACT
GGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGG
TGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGA
TTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAA
TGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAG
AATGCGACGCCAACATCAGAGCATCCTAA

>17985_17985_4_COBLL1-SMYD3_COBLL1_chr2_165697666_ENST00000375458_SMYD3_chr1_246093239_ENST00000388985_length(amino acids)=240AA_BP=
MQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGD
EQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVR
GVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRASX

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>17985_17985_5_COBLL1-SMYD3_COBLL1_chr2_165697666_ENST00000375458_SMYD3_chr1_246093239_ENST00000490107_length(transcript)=1240nt_BP=263nt
CGGCGGCGGCGCCCGCGGGCTGGGAGCCGGGGCCCGCAGGTGGAAGCGCACCCGGGAGGCGGGCCGGCCGGGGCTGGAGCGGCTCGGGCG
GGCTCTTGACGCTCAGCCAGCTTCGCTCCGGCCTCGGGAAGGCGCGCGTCCCGCCCTGACCCGCCGGCCTCTCCCACCCCAGCAGTGACG
CGCCGCCTGGGAGCTGGAGCCCGCGCAGCGCCCCGCAGGGCGATGGACGGCCGAACCCCGCGCCCGCAGGACGCCCCAGCCAGGTGATCT
GCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACC
CCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACC
TGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGG
ACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACT
GGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGG
TGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGA
TTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAA
TGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAG
AATGCGACGCCAACATCAGAGCATCCTAAGGGAACGCAGTCAGAGGGAAATACGGCGTGTGTCTTTGTTGAATGCCTTATTGAGGTCACA
CACTCTATGCTTTGTTAGCTGTGTGAACCTCTCCTATTGGAAATTCTGTTCCGTGTTTGTGTAGGTAAATAAAGGCAGACATGGTTTGCA
AACCACAAGAATCATTAGTTGTAGAGAAGCACGATTATAATAAATTCAAAACATTTGGTTGAGGATGCCA

>17985_17985_5_COBLL1-SMYD3_COBLL1_chr2_165697666_ENST00000375458_SMYD3_chr1_246093239_ENST00000490107_length(amino acids)=239AA_BP=
MQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGD
EQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVR
GVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS

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>17985_17985_6_COBLL1-SMYD3_COBLL1_chr2_165697666_ENST00000375458_SMYD3_chr1_246093239_ENST00000541742_length(transcript)=1242nt_BP=263nt
CGGCGGCGGCGCCCGCGGGCTGGGAGCCGGGGCCCGCAGGTGGAAGCGCACCCGGGAGGCGGGCCGGCCGGGGCTGGAGCGGCTCGGGCG
GGCTCTTGACGCTCAGCCAGCTTCGCTCCGGCCTCGGGAAGGCGCGCGTCCCGCCCTGACCCGCCGGCCTCTCCCACCCCAGCAGTGACG
CGCCGCCTGGGAGCTGGAGCCCGCGCAGCGCCCCGCAGGGCGATGGACGGCCGAACCCCGCGCCCGCAGGACGCCCCAGCCAGGTGATCT
GCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACC
CCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACC
TGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGG
ACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACT
GGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGG
TGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGA
TTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAA
TGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTACTTTTAGAAG
AATGCGACGCCAACATCAGAGCATCCTAAGGGAACGCAGTCAGAGGGAAATACGGCGTGTGTCTTTGTTGAATGCCTTATTGAGGTCACA
CACTCTATGCTTTGTTAGCTGTGTGAACCTCTCCTATTGGAAATTCTGTTCCGTGTTTGTGTAGGTAAATAAAGGCAGACATGGTTTGCA
AACCACAAGAATCATTAGTTGTAGAGAAGCACGATTATAATAAATTCAAAACATTTGGTTGAGGATGCCATC

>17985_17985_6_COBLL1-SMYD3_COBLL1_chr2_165697666_ENST00000375458_SMYD3_chr1_246093239_ENST00000541742_length(amino acids)=239AA_BP=
MQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGD
EQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVR
GVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS

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Fusion Gene PPI Analysis for COBLL1-SMYD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for COBLL1-SMYD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for COBLL1-SMYD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0236733Amphetamine-Related Disorders1CTD_human
TgeneC0236804Amphetamine Addiction1CTD_human
TgeneC0236807Amphetamine Abuse1CTD_human