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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AAK1-FNTA (FusionGDB2 ID:HG22848TG2339)

Fusion Gene Summary for AAK1-FNTA

check button Fusion gene summary
Fusion gene informationFusion gene name: AAK1-FNTA
Fusion gene ID: hg22848tg2339
HgeneTgene
Gene symbol

AAK1

FNTA

Gene ID

22848

2339

Gene nameAP2 associated kinase 1farnesyltransferase, CAAX box, alpha
Synonyms-FPTA|PGGT1A|PTAR2
Cytomap('AAK1')('FNTA')

2p13.3

8p11.21

Type of geneprotein-codingprotein-coding
DescriptionAP2-associated protein kinase 1adaptor-associated kinase 1protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaFTase-alphaGGTase-I-alphafarnesyl-protein transferase alpha-subunitprotein prenyltransferase alpha subunit repeat containing 2ras proteins prenyltransferase subunit alphatype
Modification date2020032220200313
UniProtAcc.

P49354

Ensembl transtripts involved in fusion geneENST00000406297, ENST00000409085, 
ENST00000409068, ENST00000470281, 
Fusion gene scores* DoF score19 X 13 X 11=271710 X 11 X 7=770
# samples 2214
** MAII scorelog2(22/2717*10)=-3.62643913669732
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/770*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AAK1 [Title/Abstract] AND FNTA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAAK1(69732700)-FNTA(42919243), # samples:2
Anticipated loss of major functional domain due to fusion event.AAK1-FNTA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AAK1-FNTA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AAK1-FNTA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AAK1-FNTA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAAK1

GO:0006468

protein phosphorylation

17494869|18657069

HgeneAAK1

GO:0032880

regulation of protein localization

18657069

HgeneAAK1

GO:0045747

positive regulation of Notch signaling pathway

21464124

HgeneAAK1

GO:0050821

protein stabilization

21464124

HgeneAAK1

GO:2000369

regulation of clathrin-dependent endocytosis

18657069

TgeneFNTA

GO:0018343

protein farnesylation

16893176|19228685

TgeneFNTA

GO:0018344

protein geranylgeranylation

16893176

TgeneFNTA

GO:0090044

positive regulation of tubulin deacetylation

19228685

TgeneFNTA

GO:0090045

positive regulation of deacetylase activity

19228685


check buttonFusion gene breakpoints across AAK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across FNTA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A8NQAAK1chr2

69732700

-FNTAchr8

42919243

+


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Fusion Gene ORF analysis for AAK1-FNTA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000406297ENST00000524546AAK1chr2

69732700

-FNTAchr8

42919243

+
5CDS-3UTRENST00000409085ENST00000524546AAK1chr2

69732700

-FNTAchr8

42919243

+
5CDS-5UTRENST00000406297ENST00000529687AAK1chr2

69732700

-FNTAchr8

42919243

+
5CDS-5UTRENST00000409085ENST00000529687AAK1chr2

69732700

-FNTAchr8

42919243

+
5CDS-intronENST00000406297ENST00000342116AAK1chr2

69732700

-FNTAchr8

42919243

+
5CDS-intronENST00000409085ENST00000342116AAK1chr2

69732700

-FNTAchr8

42919243

+
In-frameENST00000406297ENST00000302279AAK1chr2

69732700

-FNTAchr8

42919243

+
In-frameENST00000409085ENST00000302279AAK1chr2

69732700

-FNTAchr8

42919243

+
intron-3CDSENST00000409068ENST00000302279AAK1chr2

69732700

-FNTAchr8

42919243

+
intron-3CDSENST00000470281ENST00000302279AAK1chr2

69732700

-FNTAchr8

42919243

+
intron-3UTRENST00000409068ENST00000524546AAK1chr2

69732700

-FNTAchr8

42919243

+
intron-3UTRENST00000470281ENST00000524546AAK1chr2

69732700

-FNTAchr8

42919243

+
intron-5UTRENST00000409068ENST00000529687AAK1chr2

69732700

-FNTAchr8

42919243

+
intron-5UTRENST00000470281ENST00000529687AAK1chr2

69732700

-FNTAchr8

42919243

+
intron-intronENST00000409068ENST00000342116AAK1chr2

69732700

-FNTAchr8

42919243

+
intron-intronENST00000470281ENST00000342116AAK1chr2

69732700

-FNTAchr8

42919243

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409085AAK1chr269732700-ENST00000302279FNTAchr842919243+4006264627834991073
ENST00000406297AAK1chr269732700-ENST00000302279FNTAchr842919243+4006264627834991073

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409085ENST00000302279AAK1chr269732700-FNTAchr842919243+0.0041931570.9958068
ENST00000406297ENST00000302279AAK1chr269732700-FNTAchr842919243+0.0041931570.9958068

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Fusion Genomic Features for AAK1-FNTA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AAK1chr269732700-FNTAchr842919243+1.75E-081
AAK1chr269732700-FNTAchr842919243+1.75E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AAK1-FNTA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:69732700/chr8:42919243)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FNTA

P49354

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8419339, ECO:0000269|PubMed:8494894}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAAK1chr2:69732700chr8:42919243ENST00000406297-161812_42756864.0Compositional biasNote=Gly-rich
HgeneAAK1chr2:69732700chr8:42919243ENST00000406297-1618397_614756864.0Compositional biasNote=Gln-rich
HgeneAAK1chr2:69732700chr8:42919243ENST00000406297-1618658_663756864.0Compositional biasNote=Poly-Ala
HgeneAAK1chr2:69732700chr8:42919243ENST00000409085-162212_42756962.0Compositional biasNote=Gly-rich
HgeneAAK1chr2:69732700chr8:42919243ENST00000409085-1622397_614756962.0Compositional biasNote=Gln-rich
HgeneAAK1chr2:69732700chr8:42919243ENST00000409085-1622658_663756962.0Compositional biasNote=Poly-Ala
HgeneAAK1chr2:69732700chr8:42919243ENST00000406297-161846_315756864.0DomainProtein kinase
HgeneAAK1chr2:69732700chr8:42919243ENST00000409085-162246_315756962.0DomainProtein kinase
HgeneAAK1chr2:69732700chr8:42919243ENST00000406297-161852_60756864.0Nucleotide bindingATP
HgeneAAK1chr2:69732700chr8:42919243ENST00000409085-162252_60756962.0Nucleotide bindingATP
TgeneFNTAchr2:69732700chr8:42919243ENST000003421160722_310313.0Compositional biasNote=Pro-rich
TgeneFNTAchr2:69732700chr8:42919243ENST0000030227919112_14695380.0RepeatNote=PFTA 1
TgeneFNTAchr2:69732700chr8:42919243ENST0000030227919147_18095380.0RepeatNote=PFTA 2
TgeneFNTAchr2:69732700chr8:42919243ENST0000030227919181_21595380.0RepeatNote=PFTA 3
TgeneFNTAchr2:69732700chr8:42919243ENST0000030227919216_24995380.0RepeatNote=PFTA 4
TgeneFNTAchr2:69732700chr8:42919243ENST0000030227919255_28995380.0RepeatNote=PFTA 5
TgeneFNTAchr2:69732700chr8:42919243ENST0000034211607112_1460313.0RepeatNote=PFTA 1
TgeneFNTAchr2:69732700chr8:42919243ENST0000034211607147_1800313.0RepeatNote=PFTA 2
TgeneFNTAchr2:69732700chr8:42919243ENST0000034211607181_2150313.0RepeatNote=PFTA 3
TgeneFNTAchr2:69732700chr8:42919243ENST0000034211607216_2490313.0RepeatNote=PFTA 4
TgeneFNTAchr2:69732700chr8:42919243ENST0000034211607255_2890313.0RepeatNote=PFTA 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAAK1chr2:69732700chr8:42919243ENST00000406297-1618823_960756864.0RegionClathrin-binding domain (CBD)
HgeneAAK1chr2:69732700chr8:42919243ENST00000409085-1622823_960756962.0RegionClathrin-binding domain (CBD)
TgeneFNTAchr2:69732700chr8:42919243ENST000003022791922_3195380.0Compositional biasNote=Pro-rich


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Fusion Gene Sequence for AAK1-FNTA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57_57_1_AAK1-FNTA_AAK1_chr2_69732700_ENST00000406297_FNTA_chr8_42919243_ENST00000302279_length(transcript)=4006nt_BP=2646nt
GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC
CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG
GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA
GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC
TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG
GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG
GTGGATTTGCTATTGTATTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCC
AGGTGTGCAAGAGAGAAATCCAGATAATGAGGGATCTTTCAGGGCACAAGAATATTGTGGGTTACATTGATTCTAGTATCAACAACGTGA
GTAGCGGTGATGTATGGGAAGTGCTCATTCTGATGGACTTTTGTAGAGGTGGCCAGGTGGTAAACCTGATGAACCAGCGCCTGCAAACAG
GCTTTACAGAGAATGAAGTGCTCCAGATATTTTGTGATACCTGTGAAGCTGTTGCCCGCCTGCATCAGTGCAAAACTCCTATTATCCACC
GGGACCTGAAGGTTGAAAACATCCTCTTGCATGACCGAGGCCACTATGTCCTGTGTGACTTTGGAAGCGCCACCAACAAATTCCAGAATC
CACAAACTGAGGGAGTCAATGCAGTAGAAGATGAGATTAAGAAATACACAACGCTGTCCTATCGAGCACCAGAAATGGTCAACCTGTACA
GTGGCAAAATCATCACTACGAAGGCAGACATTTGGGCTCTTGGATGTTTGTTGTATAAATTATGCTACTTCACTTTGCCATTTGGGGAAA
GTCAGGTGGCAATTTGTGATGGAAACTTCACAATTCCTGATAATTCTCGATATTCTCAAGACATGCACTGCCTAATTAGGTATATGTTGG
AACCAGACCCTGACAAAAGGCCGGATATTTACCAGGTGTCCTACTTCTCATTTAAGCTACTCAAGAAAGAGTGCCCAATTCCAAATGTAC
AGAACTCTCCCATTCCTGCAAAGCTTCCTGAACCAGTGAAAGCCAGTGAGGCAGCTGCAAAAAAGACCCAGCCAAAGGCCAGACTGACAG
ATCCCATTCCCACCACAGAGACTTCAATTGCACCCCGCCAGAGGCCTAAAGCTGGGCAGACTCAGCCGAACCCAGGAATCCTTCCCATCC
AGCCAGCGCTGACACCCCGGAAGAGGGCCACTGTTCAGCCCCCACCTCAGGCTGCAGGATCCAGCAATCAGCCTGGCCTTTTAGCCAGTG
TTCCCCAACCAAAACCCCAAGCCCCACCCAGCCAGCCTCTGCCGCAAACTCAGGCCAAGCAGCCACAGGCTCCTCCCACTCCACAGCAGA
CGCCTTCTACTCAGGCCCAGGGTCTGCCCGCTCAGGCCCAGGCCACACCCCAGCACCAGCAGCAACTCTTCCTCAAGCAGCAACAGCAGC
AGCAACAGCCACCGCCAGCACAGCAGCAGCCGGCAGGCACGTTTTACCAGCAGCAGCAGGCCCAGACTCAGCAGTTTCAGGCAGTACATC
CAGCAACCCAGAAACCAGCAATTGCTCAGTTCCCTGTGGTGTCCCAAGGAGGCTCTCAACAGCAGCTAATGCAGAATTTCTACCAGCAGC
AGCAGCAGCAGCAACAACAACAGCAACAGCAACAGCTGGCCACAGCCCTGCATCAACAACAGCTGATGACTCAGCAGGCTGCCTTGCAGC
AAAAGCCCACTATGGCAGCAGGACAGCAGCCCCAGCCACAGCCAGCTGCAGCCCCACAGCCAGCCCCTGCCCAGGAGCCAGCGATTCAAG
CCCCAGTAAGACAACAGCCAAAGGTTCAGACAACCCCACCTCCTGCCGTCCAGGGGCAGAAAGTTGGATCTCTCACTCCACCCTCATCCC
CCAAAACCCAACGTGCTGGGCACAGGCGTATTCTCAGTGACGTAACCCACAGTGCAGTCTTTGGGGTCCCTGCCAGCAAATCAACCCAGC
TGCTCCAGGCAGCTGCAGCTGAGGCCAGTCTCAATAAGTCCAAGTCTGCAACCACCACTCCATCAGGCTCTCCTCGGACCTCTCAACAAA
ACGTTTATAATCCTTCAGAAGGGTCTACGTGGAATCCCTTTGATGACGATAATTTCTCCAAACTCACAGCTGAAGAACTGCTAAACAAGG
ACTTTGCCAAGCTTGGGGAAGGCAAACATCCCGAGAAGCTTGGAGGCTCAGCTGAGAGTTTGATCCCAGGCTTTCAATCAACCCAAGGTG
ATGCTTTTGCTACGACCTCATTTTCTGCTGGAACTGTTAGAGATGTTTATGATTACTTCCGAGCTGTCCTGCAGCGTGATGAAAGAAGTG
AACGAGCTTTTAAGCTAACCCGGGATGCTATTGAGTTAAATGCAGCCAATTATACAGTGTGGCATTTCCGGAGAGTTCTTTTGAAGTCAC
TTCAGAAGGATCTACATGAGGAAATGAACTACATCACTGCAATAATTGAGGAGCAGCCCAAAAACTATCAAGTTTGGCATCATAGGCGAG
TATTAGTGGAATGGCTAAGAGATCCATCTCAGGAGCTTGAATTTATTGCTGATATTCTTAATCAGGATGCAAAGAATTATCATGCCTGGC
AGCATCGACAATGGGTTATTCAGGAATTTAAACTTTGGGATAATGAGCTGCAGTATGTGGACCAACTTCTGAAAGAGGATGTGAGAAATA
ACTCTGTCTGGAACCAAAGATACTTCGTTATTTCTAACACCACTGGCTACAATGATCGTGCTGTATTGGAGAGAGAAGTCCAATACACTC
TGGAAATGATTAAACTAGTACCACATAATGAAAGTGCATGGAACTATTTGAAAGGGATTTTGCAGGATCGTGGTCTTTCCAAATATCCTA
ATCTGTTAAATCAATTACTTGATTTACAACCAAGTCATAGTTCCCCCTACCTAATTGCCTTTCTTGTGGATATCTATGAAGACATGCTAG
AAAATCAGTGTGACAATAAGGAAGACATTCTTAATAAAGCATTAGAGTTATGTGAAATCCTAGCTAAAGAAAAGGACACTATAAGAAAGG
AATATTGGAGATACATTGGAAGATCCCTTCAAAGCAAACACAGCACAGAAAATGACTCACCAACAAATGTACAGCAATAACACCATCCAG
AAGAACTTGATGGAATGCTTTTATTTTTTATTAAGGGACCCTGCAGGAGTTTCACACGAGAGTGGTCCTTCCCTTTGCCTGTGGTGTAAA
AGTGCATCACACAGGTATTGCTTTTTAACAAGAACTGATGCTCCTTGGGTGCTGCTGCTACTCAGACTAGCTCTAAGTAATGTGATTCTT
CTAAAGCAAAGTCATTGGATGGGAGGAGGAAGAAAAAGTCCCATAAAGGAACTTTTGTAGTCTTATCAACATATAATCTAATCCCTTAGC
ATCAGCTCCTCCCTCAGTGGTACATGCGTCAAGATTTGTAGCAGTAATAACTGCAGGTCACTTGTATGTAATGGATGTGAGGTAGCCGAA
GTTTGGTTCAGTAAGCAGGGAATACAGTCGTTCCATCAGAGCTGGTCTGCACACTCACATTATCTTGCTATCACTGTAACCAACTAATGC
CAAAAGAACGGTTTTGTAATAAAATTATAGCTGTATCTAAAAACAA

>57_57_1_AAK1-FNTA_AAK1_chr2_69732700_ENST00000406297_FNTA_chr8_42919243_ENST00000302279_length(amino acids)=1073AA_BP=789
MRRNPWISFLKKKKKKKKSRNHRYFALLLPIRKMKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGF
AIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFT
ENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGK
IITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNS
PIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQ
PKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPAT
QKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPV
RQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVY
NPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTVRDVYDYFRAVLQRDERSERA
FKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNYHAWQHR
QWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLL
NQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSTENDSPTNVQQ

--------------------------------------------------------------
>57_57_2_AAK1-FNTA_AAK1_chr2_69732700_ENST00000409085_FNTA_chr8_42919243_ENST00000302279_length(transcript)=4006nt_BP=2646nt
GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC
CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG
GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA
GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC
TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG
GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG
GTGGATTTGCTATTGTATTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCC
AGGTGTGCAAGAGAGAAATCCAGATAATGAGGGATCTTTCAGGGCACAAGAATATTGTGGGTTACATTGATTCTAGTATCAACAACGTGA
GTAGCGGTGATGTATGGGAAGTGCTCATTCTGATGGACTTTTGTAGAGGTGGCCAGGTGGTAAACCTGATGAACCAGCGCCTGCAAACAG
GCTTTACAGAGAATGAAGTGCTCCAGATATTTTGTGATACCTGTGAAGCTGTTGCCCGCCTGCATCAGTGCAAAACTCCTATTATCCACC
GGGACCTGAAGGTTGAAAACATCCTCTTGCATGACCGAGGCCACTATGTCCTGTGTGACTTTGGAAGCGCCACCAACAAATTCCAGAATC
CACAAACTGAGGGAGTCAATGCAGTAGAAGATGAGATTAAGAAATACACAACGCTGTCCTATCGAGCACCAGAAATGGTCAACCTGTACA
GTGGCAAAATCATCACTACGAAGGCAGACATTTGGGCTCTTGGATGTTTGTTGTATAAATTATGCTACTTCACTTTGCCATTTGGGGAAA
GTCAGGTGGCAATTTGTGATGGAAACTTCACAATTCCTGATAATTCTCGATATTCTCAAGACATGCACTGCCTAATTAGGTATATGTTGG
AACCAGACCCTGACAAAAGGCCGGATATTTACCAGGTGTCCTACTTCTCATTTAAGCTACTCAAGAAAGAGTGCCCAATTCCAAATGTAC
AGAACTCTCCCATTCCTGCAAAGCTTCCTGAACCAGTGAAAGCCAGTGAGGCAGCTGCAAAAAAGACCCAGCCAAAGGCCAGACTGACAG
ATCCCATTCCCACCACAGAGACTTCAATTGCACCCCGCCAGAGGCCTAAAGCTGGGCAGACTCAGCCGAACCCAGGAATCCTTCCCATCC
AGCCAGCGCTGACACCCCGGAAGAGGGCCACTGTTCAGCCCCCACCTCAGGCTGCAGGATCCAGCAATCAGCCTGGCCTTTTAGCCAGTG
TTCCCCAACCAAAACCCCAAGCCCCACCCAGCCAGCCTCTGCCGCAAACTCAGGCCAAGCAGCCACAGGCTCCTCCCACTCCACAGCAGA
CGCCTTCTACTCAGGCCCAGGGTCTGCCCGCTCAGGCCCAGGCCACACCCCAGCACCAGCAGCAACTCTTCCTCAAGCAGCAACAGCAGC
AGCAACAGCCACCGCCAGCACAGCAGCAGCCGGCAGGCACGTTTTACCAGCAGCAGCAGGCCCAGACTCAGCAGTTTCAGGCAGTACATC
CAGCAACCCAGAAACCAGCAATTGCTCAGTTCCCTGTGGTGTCCCAAGGAGGCTCTCAACAGCAGCTAATGCAGAATTTCTACCAGCAGC
AGCAGCAGCAGCAACAACAACAGCAACAGCAACAGCTGGCCACAGCCCTGCATCAACAACAGCTGATGACTCAGCAGGCTGCCTTGCAGC
AAAAGCCCACTATGGCAGCAGGACAGCAGCCCCAGCCACAGCCAGCTGCAGCCCCACAGCCAGCCCCTGCCCAGGAGCCAGCGATTCAAG
CCCCAGTAAGACAACAGCCAAAGGTTCAGACAACCCCACCTCCTGCCGTCCAGGGGCAGAAAGTTGGATCTCTCACTCCACCCTCATCCC
CCAAAACCCAACGTGCTGGGCACAGGCGTATTCTCAGTGACGTAACCCACAGTGCAGTCTTTGGGGTCCCTGCCAGCAAATCAACCCAGC
TGCTCCAGGCAGCTGCAGCTGAGGCCAGTCTCAATAAGTCCAAGTCTGCAACCACCACTCCATCAGGCTCTCCTCGGACCTCTCAACAAA
ACGTTTATAATCCTTCAGAAGGGTCTACGTGGAATCCCTTTGATGACGATAATTTCTCCAAACTCACAGCTGAAGAACTGCTAAACAAGG
ACTTTGCCAAGCTTGGGGAAGGCAAACATCCCGAGAAGCTTGGAGGCTCAGCTGAGAGTTTGATCCCAGGCTTTCAATCAACCCAAGGTG
ATGCTTTTGCTACGACCTCATTTTCTGCTGGAACTGTTAGAGATGTTTATGATTACTTCCGAGCTGTCCTGCAGCGTGATGAAAGAAGTG
AACGAGCTTTTAAGCTAACCCGGGATGCTATTGAGTTAAATGCAGCCAATTATACAGTGTGGCATTTCCGGAGAGTTCTTTTGAAGTCAC
TTCAGAAGGATCTACATGAGGAAATGAACTACATCACTGCAATAATTGAGGAGCAGCCCAAAAACTATCAAGTTTGGCATCATAGGCGAG
TATTAGTGGAATGGCTAAGAGATCCATCTCAGGAGCTTGAATTTATTGCTGATATTCTTAATCAGGATGCAAAGAATTATCATGCCTGGC
AGCATCGACAATGGGTTATTCAGGAATTTAAACTTTGGGATAATGAGCTGCAGTATGTGGACCAACTTCTGAAAGAGGATGTGAGAAATA
ACTCTGTCTGGAACCAAAGATACTTCGTTATTTCTAACACCACTGGCTACAATGATCGTGCTGTATTGGAGAGAGAAGTCCAATACACTC
TGGAAATGATTAAACTAGTACCACATAATGAAAGTGCATGGAACTATTTGAAAGGGATTTTGCAGGATCGTGGTCTTTCCAAATATCCTA
ATCTGTTAAATCAATTACTTGATTTACAACCAAGTCATAGTTCCCCCTACCTAATTGCCTTTCTTGTGGATATCTATGAAGACATGCTAG
AAAATCAGTGTGACAATAAGGAAGACATTCTTAATAAAGCATTAGAGTTATGTGAAATCCTAGCTAAAGAAAAGGACACTATAAGAAAGG
AATATTGGAGATACATTGGAAGATCCCTTCAAAGCAAACACAGCACAGAAAATGACTCACCAACAAATGTACAGCAATAACACCATCCAG
AAGAACTTGATGGAATGCTTTTATTTTTTATTAAGGGACCCTGCAGGAGTTTCACACGAGAGTGGTCCTTCCCTTTGCCTGTGGTGTAAA
AGTGCATCACACAGGTATTGCTTTTTAACAAGAACTGATGCTCCTTGGGTGCTGCTGCTACTCAGACTAGCTCTAAGTAATGTGATTCTT
CTAAAGCAAAGTCATTGGATGGGAGGAGGAAGAAAAAGTCCCATAAAGGAACTTTTGTAGTCTTATCAACATATAATCTAATCCCTTAGC
ATCAGCTCCTCCCTCAGTGGTACATGCGTCAAGATTTGTAGCAGTAATAACTGCAGGTCACTTGTATGTAATGGATGTGAGGTAGCCGAA
GTTTGGTTCAGTAAGCAGGGAATACAGTCGTTCCATCAGAGCTGGTCTGCACACTCACATTATCTTGCTATCACTGTAACCAACTAATGC
CAAAAGAACGGTTTTGTAATAAAATTATAGCTGTATCTAAAAACAA

>57_57_2_AAK1-FNTA_AAK1_chr2_69732700_ENST00000409085_FNTA_chr8_42919243_ENST00000302279_length(amino acids)=1073AA_BP=789
MRRNPWISFLKKKKKKKKSRNHRYFALLLPIRKMKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGF
AIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFT
ENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGK
IITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNS
PIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQ
PKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPAT
QKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPV
RQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVY
NPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTVRDVYDYFRAVLQRDERSERA
FKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNYHAWQHR
QWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLL
NQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSTENDSPTNVQQ

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Fusion Gene PPI Analysis for AAK1-FNTA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AAK1-FNTA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFNTAP49354DB06448LonafarnibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for AAK1-FNTA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource