Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:FNDC3A-RB1 (FusionGDB2 ID:HG22862TG5925)

Fusion Gene Summary for FNDC3A-RB1

check button Fusion gene summary
Fusion gene informationFusion gene name: FNDC3A-RB1
Fusion gene ID: hg22862tg5925
HgeneTgene
Gene symbol

FNDC3A

RB1

Gene ID

22862

5925

Gene namefibronectin type III domain containing 3ARB transcriptional corepressor 1
SynonymsFNDC3|HUGO|bA203I16.1|bA203I16.5OSRC|PPP1R130|RB|p105-Rb|p110-RB1|pRb|pp110
Cytomap('FNDC3A')('RB1')

13q14.2

13q14.2

Type of geneprotein-codingprotein-coding
Descriptionfibronectin type-III domain-containing protein 3Ahuman gene expressed in odontoblastsretinoblastoma-associated proteinGOS563 exon 17 substitution mutation causes premature stopexon 17 tumor GOS561 substitution mutation causes premature stopprepro-retinoblastoma-associated proteinprotein phosphatase 1, regulatory subunit 130retinoblas
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000398316, ENST00000492622, 
ENST00000541916, 		ENST00000398316, 
ENST00000492622, ENST00000541916, 
Fusion gene scores* DoF score15 X 12 X 7=126013 X 16 X 11=2288
# samples 1627
** MAII scorelog2(16/1260*10)=-2.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/2288*10)=-3.08305573972756
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FNDC3A [Title/Abstract] AND RB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFNDC3A(49688867)-RB1(49037867), # samples:2
Anticipated loss of major functional domain due to fusion event.FNDC3A-RB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FNDC3A-RB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FNDC3A-RB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FNDC3A-RB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RB1-FNDC3A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RB1-FNDC3A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRB1

GO:0043550

regulation of lipid kinase activity

16286473

TgeneRB1

GO:0045892

negative regulation of transcription, DNA-templated

10783144|12065415|19223331

TgeneRB1

GO:2000679

positive regulation of transcription regulatory region DNA binding

25100735


check buttonFusion gene breakpoints across FNDC3A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A12K-01AFNDC3Achr13

49688867

-RB1chr13

49037867

+
ChimerDB4BRCATCGA-C8-A12K-01AFNDC3Achr13

49688867

+RB1chr13

49037867

+
ChimerDB4BRCATCGA-C8-A12K-01AFNDC3Achr13

49688867

+RB1chr13

49039134

+
ChimerDB4CESCTCGA-C5-A3HE-01AFNDC3Achr13

49551053

-RB1chr13

48881416

+


Top

Fusion Gene ORF analysis for FNDC3A-RB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000398316ENST00000484879FNDC3Achr13

49688867

+RB1chr13

49037867

+
5CDS-intronENST00000398316ENST00000484879FNDC3Achr13

49688867

+RB1chr13

49039134

+
5CDS-intronENST00000492622ENST00000484879FNDC3Achr13

49688867

+RB1chr13

49037867

+
5CDS-intronENST00000492622ENST00000484879FNDC3Achr13

49688867

+RB1chr13

49039134

+
5CDS-intronENST00000541916ENST00000484879FNDC3Achr13

49688867

+RB1chr13

49037867

+
5CDS-intronENST00000541916ENST00000484879FNDC3Achr13

49688867

+RB1chr13

49039134

+
5UTR-3CDSENST00000541916ENST00000267163FNDC3Achr13

49551053

-RB1chr13

48881416

+
5UTR-intronENST00000541916ENST00000484879FNDC3Achr13

49551053

-RB1chr13

48881416

+
In-frameENST00000398316ENST00000267163FNDC3Achr13

49688867

+RB1chr13

49037867

+
In-frameENST00000398316ENST00000267163FNDC3Achr13

49688867

+RB1chr13

49039134

+
In-frameENST00000492622ENST00000267163FNDC3Achr13

49688867

+RB1chr13

49037867

+
In-frameENST00000492622ENST00000267163FNDC3Achr13

49688867

+RB1chr13

49039134

+
In-frameENST00000541916ENST00000267163FNDC3Achr13

49688867

+RB1chr13

49037867

+
In-frameENST00000541916ENST00000267163FNDC3Achr13

49688867

+RB1chr13

49039134

+
intron-3CDSENST00000398316ENST00000267163FNDC3Achr13

49551053

-RB1chr13

48881416

+
intron-3CDSENST00000492622ENST00000267163FNDC3Achr13

49551053

-RB1chr13

48881416

+
intron-intronENST00000398316ENST00000484879FNDC3Achr13

49551053

-RB1chr13

48881416

+
intron-intronENST00000492622ENST00000484879FNDC3Achr13

49551053

-RB1chr13

48881416

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000492622FNDC3Achr1349688867+ENST00000267163RB1chr1349037867+31535572991237312
ENST00000541916FNDC3Achr1349688867+ENST00000267163RB1chr1349037867+2921325671005312
ENST00000398316FNDC3Achr1349688867+ENST00000267163RB1chr1349037867+276717145851268
ENST00000492622FNDC3Achr1349688867+ENST00000267163RB1chr1349039134+30485572991132277
ENST00000541916FNDC3Achr1349688867+ENST00000267163RB1chr1349039134+281632567900277
ENST00000398316FNDC3Achr1349688867+ENST00000267163RB1chr1349039134+266217145746233

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000492622ENST00000267163FNDC3Achr1349688867+RB1chr1349037867+0.000116380.99988365
ENST00000541916ENST00000267163FNDC3Achr1349688867+RB1chr1349037867+8.05E-050.99991953
ENST00000398316ENST00000267163FNDC3Achr1349688867+RB1chr1349037867+0.0003767890.9996232
ENST00000492622ENST00000267163FNDC3Achr1349688867+RB1chr1349039134+0.0001090670.9998909
ENST00000541916ENST00000267163FNDC3Achr1349688867+RB1chr1349039134+9.00E-050.99991
ENST00000398316ENST00000267163FNDC3Achr1349688867+RB1chr1349039134+0.0007202670.9992798

Top

Fusion Genomic Features for FNDC3A-RB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FNDC3Achr1349688867+RB1chr1349037866+2.19E-050.99997807
FNDC3Achr1349688867+RB1chr1349039133+2.96E-060.999997
FNDC3Achr1349688867+RB1chr1349037866+2.19E-050.99997807
FNDC3Achr1349688867+RB1chr1349039133+2.96E-060.999997

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for FNDC3A-RB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:49688867/chr13:49037867)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRB1chr13:49688867chr13:49037867ENST000002671631927860_876702929.0MotifBipartite nuclear localization signal
TgeneRB1chr13:49688867chr13:49039134ENST000002671632027860_876737929.0MotifBipartite nuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+22468_133281143.0Compositional biasNote=Pro-rich
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+42668_133841199.0Compositional biasNote=Pro-rich
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+42668_133841199.0Compositional biasNote=Pro-rich
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000398316+22468_133281143.0Compositional biasNote=Pro-rich
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000492622+42668_133841199.0Compositional biasNote=Pro-rich
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000541916+42668_133841199.0Compositional biasNote=Pro-rich
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+2241046_1151281143.0DomainFibronectin type-III 9
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+224268_369281143.0DomainFibronectin type-III 1
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+224373_465281143.0DomainFibronectin type-III 2
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+224469_562281143.0DomainFibronectin type-III 3
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+224566_660281143.0DomainFibronectin type-III 4
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+224664_757281143.0DomainFibronectin type-III 5
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+224761_851281143.0DomainFibronectin type-III 6
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+224861_950281143.0DomainFibronectin type-III 7
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+224951_1045281143.0DomainFibronectin type-III 8
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+4261046_1151841199.0DomainFibronectin type-III 9
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+426268_369841199.0DomainFibronectin type-III 1
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+426373_465841199.0DomainFibronectin type-III 2
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+426469_562841199.0DomainFibronectin type-III 3
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+426566_660841199.0DomainFibronectin type-III 4
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+426664_757841199.0DomainFibronectin type-III 5
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+426761_851841199.0DomainFibronectin type-III 6
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+426861_950841199.0DomainFibronectin type-III 7
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+426951_1045841199.0DomainFibronectin type-III 8
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+4261046_1151841199.0DomainFibronectin type-III 9
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+426268_369841199.0DomainFibronectin type-III 1
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+426373_465841199.0DomainFibronectin type-III 2
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+426469_562841199.0DomainFibronectin type-III 3
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+426566_660841199.0DomainFibronectin type-III 4
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+426664_757841199.0DomainFibronectin type-III 5
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+426761_851841199.0DomainFibronectin type-III 6
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+426861_950841199.0DomainFibronectin type-III 7
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+426951_1045841199.0DomainFibronectin type-III 8
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000398316+2241046_1151281143.0DomainFibronectin type-III 9
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000398316+224268_369281143.0DomainFibronectin type-III 1
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000398316+224373_465281143.0DomainFibronectin type-III 2
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000398316+224469_562281143.0DomainFibronectin type-III 3
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000398316+224566_660281143.0DomainFibronectin type-III 4
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000398316+224664_757281143.0DomainFibronectin type-III 5
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000398316+224761_851281143.0DomainFibronectin type-III 6
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000398316+224861_950281143.0DomainFibronectin type-III 7
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000398316+224951_1045281143.0DomainFibronectin type-III 8
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000492622+4261046_1151841199.0DomainFibronectin type-III 9
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000492622+426268_369841199.0DomainFibronectin type-III 1
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000492622+426373_465841199.0DomainFibronectin type-III 2
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000492622+426469_562841199.0DomainFibronectin type-III 3
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000492622+426566_660841199.0DomainFibronectin type-III 4
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000492622+426664_757841199.0DomainFibronectin type-III 5
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000492622+426761_851841199.0DomainFibronectin type-III 6
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000492622+426861_950841199.0DomainFibronectin type-III 7
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000492622+426951_1045841199.0DomainFibronectin type-III 8
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000541916+4261046_1151841199.0DomainFibronectin type-III 9
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000541916+426268_369841199.0DomainFibronectin type-III 1
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000541916+426373_465841199.0DomainFibronectin type-III 2
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000541916+426469_562841199.0DomainFibronectin type-III 3
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000541916+426566_660841199.0DomainFibronectin type-III 4
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000541916+426664_757841199.0DomainFibronectin type-III 5
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000541916+426761_851841199.0DomainFibronectin type-III 6
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000541916+426861_950841199.0DomainFibronectin type-III 7
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000541916+426951_1045841199.0DomainFibronectin type-III 8
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+2241177_1197281143.0TransmembraneHelical
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+4261177_1197841199.0TransmembraneHelical
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+4261177_1197841199.0TransmembraneHelical
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000398316+2241177_1197281143.0TransmembraneHelical
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000492622+4261177_1197841199.0TransmembraneHelical
HgeneFNDC3Achr13:49688867chr13:49039134ENST00000541916+4261177_1197841199.0TransmembraneHelical
TgeneRB1chr13:49688867chr13:49037867ENST00000267163192710_18702929.0Compositional biasNote=Poly-Ala
TgeneRB1chr13:49688867chr13:49037867ENST00000267163192720_29702929.0Compositional biasNote=Poly-Pro
TgeneRB1chr13:49688867chr13:49039134ENST00000267163202710_18737929.0Compositional biasNote=Poly-Ala
TgeneRB1chr13:49688867chr13:49039134ENST00000267163202720_29737929.0Compositional biasNote=Poly-Pro
TgeneRB1chr13:49688867chr13:49037867ENST000002671631927373_579702929.0RegionNote=Domain A
TgeneRB1chr13:49688867chr13:49037867ENST000002671631927373_771702929.0RegionNote=Pocket%3B binds T and E1A
TgeneRB1chr13:49688867chr13:49037867ENST000002671631927580_639702929.0RegionNote=Spacer
TgeneRB1chr13:49688867chr13:49037867ENST000002671631927640_771702929.0RegionNote=Domain B
TgeneRB1chr13:49688867chr13:49039134ENST000002671632027373_579737929.0RegionNote=Domain A
TgeneRB1chr13:49688867chr13:49039134ENST000002671632027373_771737929.0RegionNote=Pocket%3B binds T and E1A
TgeneRB1chr13:49688867chr13:49039134ENST000002671632027580_639737929.0RegionNote=Spacer
TgeneRB1chr13:49688867chr13:49039134ENST000002671632027640_771737929.0RegionNote=Domain B


Top

Fusion Gene Sequence for FNDC3A-RB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30903_30903_1_FNDC3A-RB1_FNDC3A_chr13_49688867_ENST00000398316_RB1_chr13_49037867_ENST00000267163_length(transcript)=2767nt_BP=171nt
AGCCGTTCTCCAATTAAAGCTGTTAACGTGTACTACGCTGTTTCCTTGTTGGATTTTCTTGTTCTCTGCTGCTACTGTAAAAACGAAATG
AGTGGTCCTGCTCAGGTTCCAATGATGTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTCCTGGATATGCCCCACAGATTATGATG
TGTTCCATGTATGGCATATGCAAAGTGAAGAATATAGACCTTAAATTCAAAATCATTGTAACAGCATACAAGGATCTTCCTCATGCTGTT
CAGGAGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAA
ACAAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCA
CCCTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATG
ACTCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGC
GACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCA
GATGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAA
ATGAATGATAGCATGGATACCTCAAACAAGGAAGAGAAATGAGGATCTCAGGACCTTGGTGGACACTGTGTACACCTCTGGATTCATTGT
CTCTCACAGATGTGACTGTATAACTTTCCCAGGTTCTGTTTATGGCCACATTTAATATCTTCAGCTCTTTTTGTGGATATAAAATGTGCA
GATGCAATTGTTTGGGTGATTCCTAAGCCACTTGAAATGTTAGTCATTGTTATTTATACAAGATTGAAAATCTTGTGTAAATCCTGCCAT
TTAAAAAGTTGTAGCAGATTGTTTCCTCTTCCAAAGTAAAATTGCTGTGCTTTATGGATAGTAAGAATGGCCCTAGAGTGGGAGTCCTGA
TAACCCAGGCCTGTCTGACTACTTTGCCTTCTTTTGTAGCATATAGGTGATGTTTGCTCTTGTTTTTATTAATTTATATGTATATTTTTT
TAATTTAACATGAACACCCTTAGAAAATGTGTCCTATCTATCTTCCAAATGCAATTTGATTGACTGCCCATTCACCAAAATTATCCTGAA
CTCTTCTGCAAAAATGGATATTATTAGAAATTAGAAAAAAATTACTAATTTTACACATTAGATTTTATTTTACTATTGGAATCTGATATA
CTGTGTGCTTGTTTTATAAAATTTTGCTTTTAATTAAATAAAAGCTGGAAGCAAAGTATAACCATATGATACTATCATACTACTGAAACA
GATTTCATACCTCAGAATGTAAAAGAACTTACTGATTATTTTCTTCATCCAACTTATGTTTTTAAATGAGGATTATTGATAGTACTCTTG
GTTTTTATACCATTCAGATCACTGAATTTATAAAGTACCCATCTAGTACTTGAAAAAGTAAAGTGTTCTGCCAGATCTTAGGTATAGAGG
ACCCTAACACAGTATATCCCAAGTGCACTTTCTAATGTTTCTGGGTCCTGAAGAATTAAGATACAAATTAATTTTACTCCATAAACAGAC
TGTTAATTATAGGAGCCTTAATTTTTTTTTCATAGAGATTTGTCTAATTGCATCTCAAAATTATTCTGCCCTCCTTAATTTGGGAAGGTT
TGTGTTTTCTCTGGAATGGTACATGTCTTCCATGTATCTTTTGAACTGGCAATTGTCTATTTATCTTTTATTTTTTTAAGTCAGTATGGT
CTAACACTGGCATGTTCAAAGCCACATTATTTCTAGTCCAAAATTACAAGTAATCAAGGGTCATTATGGGTTAGGCATTAATGTTTCTAT
CTGATTTTGTGCAAAAGCTTCAAATTAAAACAGCTGCATTAGAAAAAGAGGCGCTTCTCCCCTCCCCTACACCTAAAGGTGTATTTAAAC
TATCTTGTGTGATTAACTTATTTAGAGATGCTGTAACTTAAAATAGGGGATATTTAAGGTAGCTTCAGCTAGCTTTTAGGAAAATCACTT
TGTCTAACTCAGAATTATTTTTAAAAAGAAATCTGGTCTTGTTAGAAAACAAAATTTTATTTTGTGCTCATTTAAGTTTCAAACTTACTA
TTTTGACAGTTATTTTGATAACAATGACACTAGAAAACTTGACTCCATTTCATCATTGTTTCTGCATGAATATCATACAAATCAGTTAGT
TTTTAGGTCAAGGGCTTACTATTTCTGGGTCTTTTGCTACTAAGTTCACATTAGAATTAGTGCCAGAATTTTAGGAACTTCAGAGATCGT
GTATTGAGATTTCTTAAATAATGCTTCAGATATTATTGCTTTATTGCTTTTTTGTATTGGTTAAAACTGTACATTTAAAATTGCTATGTT
ACTATTTTCTACAATTAATAGTTTGTCTATTTTAAAATAAATTAGTTGTTAAGAGTCTTAATGGTCTGATGTTGTGTTCTTTGTATTAAG

>30903_30903_1_FNDC3A-RB1_FNDC3A_chr13_49688867_ENST00000398316_RB1_chr13_49037867_ENST00000267163_length(amino acids)=268AA_BP=42
MLDFLVLCCYCKNEMSGPAQVPMMSPNGSVPPIYVPPGYAPQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYD
SIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFG

--------------------------------------------------------------
>30903_30903_2_FNDC3A-RB1_FNDC3A_chr13_49688867_ENST00000398316_RB1_chr13_49039134_ENST00000267163_length(transcript)=2662nt_BP=171nt
AGCCGTTCTCCAATTAAAGCTGTTAACGTGTACTACGCTGTTTCCTTGTTGGATTTTCTTGTTCTCTGCTGCTACTGTAAAAACGAAATG
AGTGGTCCTGCTCAGGTTCCAATGATGTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTCCTGGATATGCCCCACAGACATTCAAA
CGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACAAATATTTTGCAG
TATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGGATTCCT
GGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACTCCAAGATCAAGA
ATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGACCGTGTGCTCAAA
AGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGATGGAAGTAAACAT
CTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAATGAATGATAGCATG
GATACCTCAAACAAGGAAGAGAAATGAGGATCTCAGGACCTTGGTGGACACTGTGTACACCTCTGGATTCATTGTCTCTCACAGATGTGA
CTGTATAACTTTCCCAGGTTCTGTTTATGGCCACATTTAATATCTTCAGCTCTTTTTGTGGATATAAAATGTGCAGATGCAATTGTTTGG
GTGATTCCTAAGCCACTTGAAATGTTAGTCATTGTTATTTATACAAGATTGAAAATCTTGTGTAAATCCTGCCATTTAAAAAGTTGTAGC
AGATTGTTTCCTCTTCCAAAGTAAAATTGCTGTGCTTTATGGATAGTAAGAATGGCCCTAGAGTGGGAGTCCTGATAACCCAGGCCTGTC
TGACTACTTTGCCTTCTTTTGTAGCATATAGGTGATGTTTGCTCTTGTTTTTATTAATTTATATGTATATTTTTTTAATTTAACATGAAC
ACCCTTAGAAAATGTGTCCTATCTATCTTCCAAATGCAATTTGATTGACTGCCCATTCACCAAAATTATCCTGAACTCTTCTGCAAAAAT
GGATATTATTAGAAATTAGAAAAAAATTACTAATTTTACACATTAGATTTTATTTTACTATTGGAATCTGATATACTGTGTGCTTGTTTT
ATAAAATTTTGCTTTTAATTAAATAAAAGCTGGAAGCAAAGTATAACCATATGATACTATCATACTACTGAAACAGATTTCATACCTCAG
AATGTAAAAGAACTTACTGATTATTTTCTTCATCCAACTTATGTTTTTAAATGAGGATTATTGATAGTACTCTTGGTTTTTATACCATTC
AGATCACTGAATTTATAAAGTACCCATCTAGTACTTGAAAAAGTAAAGTGTTCTGCCAGATCTTAGGTATAGAGGACCCTAACACAGTAT
ATCCCAAGTGCACTTTCTAATGTTTCTGGGTCCTGAAGAATTAAGATACAAATTAATTTTACTCCATAAACAGACTGTTAATTATAGGAG
CCTTAATTTTTTTTTCATAGAGATTTGTCTAATTGCATCTCAAAATTATTCTGCCCTCCTTAATTTGGGAAGGTTTGTGTTTTCTCTGGA
ATGGTACATGTCTTCCATGTATCTTTTGAACTGGCAATTGTCTATTTATCTTTTATTTTTTTAAGTCAGTATGGTCTAACACTGGCATGT
TCAAAGCCACATTATTTCTAGTCCAAAATTACAAGTAATCAAGGGTCATTATGGGTTAGGCATTAATGTTTCTATCTGATTTTGTGCAAA
AGCTTCAAATTAAAACAGCTGCATTAGAAAAAGAGGCGCTTCTCCCCTCCCCTACACCTAAAGGTGTATTTAAACTATCTTGTGTGATTA
ACTTATTTAGAGATGCTGTAACTTAAAATAGGGGATATTTAAGGTAGCTTCAGCTAGCTTTTAGGAAAATCACTTTGTCTAACTCAGAAT
TATTTTTAAAAAGAAATCTGGTCTTGTTAGAAAACAAAATTTTATTTTGTGCTCATTTAAGTTTCAAACTTACTATTTTGACAGTTATTT
TGATAACAATGACACTAGAAAACTTGACTCCATTTCATCATTGTTTCTGCATGAATATCATACAAATCAGTTAGTTTTTAGGTCAAGGGC
TTACTATTTCTGGGTCTTTTGCTACTAAGTTCACATTAGAATTAGTGCCAGAATTTTAGGAACTTCAGAGATCGTGTATTGAGATTTCTT
AAATAATGCTTCAGATATTATTGCTTTATTGCTTTTTTGTATTGGTTAAAACTGTACATTTAAAATTGCTATGTTACTATTTTCTACAAT
TAATAGTTTGTCTATTTTAAAATAAATTAGTTGTTAAGAGTCTTAATGGTCTGATGTTGTGTTCTTTGTATTAAGTACACTAATGTTCTC

>30903_30903_2_FNDC3A-RB1_FNDC3A_chr13_49688867_ENST00000398316_RB1_chr13_49039134_ENST00000267163_length(amino acids)=233AA_BP=40
MLDFLVLCCYCKNEMSGPAQVPMMSPNGSVPPIYVPPGYAPQTFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHI
PRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKL

--------------------------------------------------------------
>30903_30903_3_FNDC3A-RB1_FNDC3A_chr13_49688867_ENST00000492622_RB1_chr13_49037867_ENST00000267163_length(transcript)=3153nt_BP=557nt
CTCCCGGCTCCGTAGTAAGCATGGCGGCGGCGGCGTTCGTGGTCCCTCGGGTGAAACAGAAAGCGGGAGCTACGCGGAGAGGGAGCGAAG
AGCGGGGCTGAGGCGGCGGCGTCACTGCCAGGAAACAACCCCAACAGTCAGCGCGCCGGCGGCCGCGGCGGCCCTGAGAGCTGACTCTGC
AGCTGAGGTAGAGAGACAACGATCAGGAACCCTAAGAAGAGGCGCCAGAGGAGCCGCCTTCTGCCTCAGAACGGCGTGACTCGGAGAATT
GGAGCGTTATTCAGTATATTAATGTCTTATTGATAATGGCAGAACATCCACCACTACTGGATACAACTCAGATCTTAAGTAGTGATATTT
CTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGAACACAACAGGTTATTCTGGTACAAGTTAACCCAGGAGAAGCATTTACAATAAGAA
GAGAAGATGGACAGTTTCAGTGCATTACAGGTCCTGCTCAGGTTCCAATGATGTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTC
CTGGATATGCCCCACAGATTATGATGTGTTCCATGTATGGCATATGCAAAGTGAAGAATATAGACCTTAAATTCAAAATCATTGTAACAG
CATACAAGGATCTTCCTCATGCTGTTCAGGAGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATA
ACTCGGTCTTCATGCAGAGACTGAAAACAAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTC
GAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAG
AAGGTCTGCCAACACCAACAAAAATGACTCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGA
AAATAAATCAGATGGTATGTAACAGCGACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCT
TTGATATTGAAGGATCAGATGAAGCAGATGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTA
CTCGAACACGAATGCAAAAGCAGAAAATGAATGATAGCATGGATACCTCAAACAAGGAAGAGAAATGAGGATCTCAGGACCTTGGTGGAC
ACTGTGTACACCTCTGGATTCATTGTCTCTCACAGATGTGACTGTATAACTTTCCCAGGTTCTGTTTATGGCCACATTTAATATCTTCAG
CTCTTTTTGTGGATATAAAATGTGCAGATGCAATTGTTTGGGTGATTCCTAAGCCACTTGAAATGTTAGTCATTGTTATTTATACAAGAT
TGAAAATCTTGTGTAAATCCTGCCATTTAAAAAGTTGTAGCAGATTGTTTCCTCTTCCAAAGTAAAATTGCTGTGCTTTATGGATAGTAA
GAATGGCCCTAGAGTGGGAGTCCTGATAACCCAGGCCTGTCTGACTACTTTGCCTTCTTTTGTAGCATATAGGTGATGTTTGCTCTTGTT
TTTATTAATTTATATGTATATTTTTTTAATTTAACATGAACACCCTTAGAAAATGTGTCCTATCTATCTTCCAAATGCAATTTGATTGAC
TGCCCATTCACCAAAATTATCCTGAACTCTTCTGCAAAAATGGATATTATTAGAAATTAGAAAAAAATTACTAATTTTACACATTAGATT
TTATTTTACTATTGGAATCTGATATACTGTGTGCTTGTTTTATAAAATTTTGCTTTTAATTAAATAAAAGCTGGAAGCAAAGTATAACCA
TATGATACTATCATACTACTGAAACAGATTTCATACCTCAGAATGTAAAAGAACTTACTGATTATTTTCTTCATCCAACTTATGTTTTTA
AATGAGGATTATTGATAGTACTCTTGGTTTTTATACCATTCAGATCACTGAATTTATAAAGTACCCATCTAGTACTTGAAAAAGTAAAGT
GTTCTGCCAGATCTTAGGTATAGAGGACCCTAACACAGTATATCCCAAGTGCACTTTCTAATGTTTCTGGGTCCTGAAGAATTAAGATAC
AAATTAATTTTACTCCATAAACAGACTGTTAATTATAGGAGCCTTAATTTTTTTTTCATAGAGATTTGTCTAATTGCATCTCAAAATTAT
TCTGCCCTCCTTAATTTGGGAAGGTTTGTGTTTTCTCTGGAATGGTACATGTCTTCCATGTATCTTTTGAACTGGCAATTGTCTATTTAT
CTTTTATTTTTTTAAGTCAGTATGGTCTAACACTGGCATGTTCAAAGCCACATTATTTCTAGTCCAAAATTACAAGTAATCAAGGGTCAT
TATGGGTTAGGCATTAATGTTTCTATCTGATTTTGTGCAAAAGCTTCAAATTAAAACAGCTGCATTAGAAAAAGAGGCGCTTCTCCCCTC
CCCTACACCTAAAGGTGTATTTAAACTATCTTGTGTGATTAACTTATTTAGAGATGCTGTAACTTAAAATAGGGGATATTTAAGGTAGCT
TCAGCTAGCTTTTAGGAAAATCACTTTGTCTAACTCAGAATTATTTTTAAAAAGAAATCTGGTCTTGTTAGAAAACAAAATTTTATTTTG
TGCTCATTTAAGTTTCAAACTTACTATTTTGACAGTTATTTTGATAACAATGACACTAGAAAACTTGACTCCATTTCATCATTGTTTCTG
CATGAATATCATACAAATCAGTTAGTTTTTAGGTCAAGGGCTTACTATTTCTGGGTCTTTTGCTACTAAGTTCACATTAGAATTAGTGCC
AGAATTTTAGGAACTTCAGAGATCGTGTATTGAGATTTCTTAAATAATGCTTCAGATATTATTGCTTTATTGCTTTTTTGTATTGGTTAA
AACTGTACATTTAAAATTGCTATGTTACTATTTTCTACAATTAATAGTTTGTCTATTTTAAAATAAATTAGTTGTTAAGAGTCTTAATGG
TCTGATGTTGTGTTCTTTGTATTAAGTACACTAATGTTCTCTTTTCTGTCTAGGAGAAGATAGATAGAAGATAACTCTCCTAGTATCTCA

>30903_30903_3_FNDC3A-RB1_FNDC3A_chr13_49688867_ENST00000492622_RB1_chr13_49037867_ENST00000267163_length(amino acids)=312AA_BP=86
MIMAEHPPLLDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGPAQVPMMSPNGSVPPIYVPPGYAPQIMMC
SMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSP
LRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEAD

--------------------------------------------------------------
>30903_30903_4_FNDC3A-RB1_FNDC3A_chr13_49688867_ENST00000492622_RB1_chr13_49039134_ENST00000267163_length(transcript)=3048nt_BP=557nt
CTCCCGGCTCCGTAGTAAGCATGGCGGCGGCGGCGTTCGTGGTCCCTCGGGTGAAACAGAAAGCGGGAGCTACGCGGAGAGGGAGCGAAG
AGCGGGGCTGAGGCGGCGGCGTCACTGCCAGGAAACAACCCCAACAGTCAGCGCGCCGGCGGCCGCGGCGGCCCTGAGAGCTGACTCTGC
AGCTGAGGTAGAGAGACAACGATCAGGAACCCTAAGAAGAGGCGCCAGAGGAGCCGCCTTCTGCCTCAGAACGGCGTGACTCGGAGAATT
GGAGCGTTATTCAGTATATTAATGTCTTATTGATAATGGCAGAACATCCACCACTACTGGATACAACTCAGATCTTAAGTAGTGATATTT
CTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGAACACAACAGGTTATTCTGGTACAAGTTAACCCAGGAGAAGCATTTACAATAAGAA
GAGAAGATGGACAGTTTCAGTGCATTACAGGTCCTGCTCAGGTTCCAATGATGTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTC
CTGGATATGCCCCACAGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGC
AGAGACTGAAAACAAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGT
TTCCTAGTTCACCCTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACAC
CAACAAAAATGACTCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGG
TATGTAACAGCGACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGAT
CAGATGAAGCAGATGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGC
AAAAGCAGAAAATGAATGATAGCATGGATACCTCAAACAAGGAAGAGAAATGAGGATCTCAGGACCTTGGTGGACACTGTGTACACCTCT
GGATTCATTGTCTCTCACAGATGTGACTGTATAACTTTCCCAGGTTCTGTTTATGGCCACATTTAATATCTTCAGCTCTTTTTGTGGATA
TAAAATGTGCAGATGCAATTGTTTGGGTGATTCCTAAGCCACTTGAAATGTTAGTCATTGTTATTTATACAAGATTGAAAATCTTGTGTA
AATCCTGCCATTTAAAAAGTTGTAGCAGATTGTTTCCTCTTCCAAAGTAAAATTGCTGTGCTTTATGGATAGTAAGAATGGCCCTAGAGT
GGGAGTCCTGATAACCCAGGCCTGTCTGACTACTTTGCCTTCTTTTGTAGCATATAGGTGATGTTTGCTCTTGTTTTTATTAATTTATAT
GTATATTTTTTTAATTTAACATGAACACCCTTAGAAAATGTGTCCTATCTATCTTCCAAATGCAATTTGATTGACTGCCCATTCACCAAA
ATTATCCTGAACTCTTCTGCAAAAATGGATATTATTAGAAATTAGAAAAAAATTACTAATTTTACACATTAGATTTTATTTTACTATTGG
AATCTGATATACTGTGTGCTTGTTTTATAAAATTTTGCTTTTAATTAAATAAAAGCTGGAAGCAAAGTATAACCATATGATACTATCATA
CTACTGAAACAGATTTCATACCTCAGAATGTAAAAGAACTTACTGATTATTTTCTTCATCCAACTTATGTTTTTAAATGAGGATTATTGA
TAGTACTCTTGGTTTTTATACCATTCAGATCACTGAATTTATAAAGTACCCATCTAGTACTTGAAAAAGTAAAGTGTTCTGCCAGATCTT
AGGTATAGAGGACCCTAACACAGTATATCCCAAGTGCACTTTCTAATGTTTCTGGGTCCTGAAGAATTAAGATACAAATTAATTTTACTC
CATAAACAGACTGTTAATTATAGGAGCCTTAATTTTTTTTTCATAGAGATTTGTCTAATTGCATCTCAAAATTATTCTGCCCTCCTTAAT
TTGGGAAGGTTTGTGTTTTCTCTGGAATGGTACATGTCTTCCATGTATCTTTTGAACTGGCAATTGTCTATTTATCTTTTATTTTTTTAA
GTCAGTATGGTCTAACACTGGCATGTTCAAAGCCACATTATTTCTAGTCCAAAATTACAAGTAATCAAGGGTCATTATGGGTTAGGCATT
AATGTTTCTATCTGATTTTGTGCAAAAGCTTCAAATTAAAACAGCTGCATTAGAAAAAGAGGCGCTTCTCCCCTCCCCTACACCTAAAGG
TGTATTTAAACTATCTTGTGTGATTAACTTATTTAGAGATGCTGTAACTTAAAATAGGGGATATTTAAGGTAGCTTCAGCTAGCTTTTAG
GAAAATCACTTTGTCTAACTCAGAATTATTTTTAAAAAGAAATCTGGTCTTGTTAGAAAACAAAATTTTATTTTGTGCTCATTTAAGTTT
CAAACTTACTATTTTGACAGTTATTTTGATAACAATGACACTAGAAAACTTGACTCCATTTCATCATTGTTTCTGCATGAATATCATACA
AATCAGTTAGTTTTTAGGTCAAGGGCTTACTATTTCTGGGTCTTTTGCTACTAAGTTCACATTAGAATTAGTGCCAGAATTTTAGGAACT
TCAGAGATCGTGTATTGAGATTTCTTAAATAATGCTTCAGATATTATTGCTTTATTGCTTTTTTGTATTGGTTAAAACTGTACATTTAAA
ATTGCTATGTTACTATTTTCTACAATTAATAGTTTGTCTATTTTAAAATAAATTAGTTGTTAAGAGTCTTAATGGTCTGATGTTGTGTTC

>30903_30903_4_FNDC3A-RB1_FNDC3A_chr13_49688867_ENST00000492622_RB1_chr13_49039134_ENST00000267163_length(amino acids)=277AA_BP=84
MIMAEHPPLLDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGPAQVPMMSPNGSVPPIYVPPGYAPQTFKR
VLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRI
LVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTSTRTRMQKQKMNDSMD

--------------------------------------------------------------
>30903_30903_5_FNDC3A-RB1_FNDC3A_chr13_49688867_ENST00000541916_RB1_chr13_49037867_ENST00000267163_length(transcript)=2921nt_BP=325nt
TTGACACGGCTTTGGAAACGACGTCATGTGTTAGAATTGGAGCGTTATTCAGTATATTAATGTCTTATTGATAATGGCAGAACATCCACC
ACTACTGGATACAACTCAGATCTTAAGTAGTGATATTTCTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGAACACAACAGGTTATTCT
GGTACAAGTTAACCCAGGAGAAGCATTTACAATAAGAAGAGAAGATGGACAGTTTCAGTGCATTACAGGTCCTGCTCAGGTTCCAATGAT
GTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTCCTGGATATGCCCCACAGATTATGATGTGTTCCATGTATGGCATATGCAAAGT
GAAGAATATAGACCTTAAATTCAAAATCATTGTAACAGCATACAAGGATCTTCCTCATGCTGTTCAGGAGACATTCAAACGTGTTTTGAT
CAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACAAATATTTTGCAGTATGCTTCCAC
CAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGGATTCCTGGAGGGAACAT
CTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACTCCAAGATCAAGAATCTTAGTATC
AATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGACCGTGTGCTCAAAAGAAGTGCTGA
AGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGATGGAAGTAAACATCTCCCAGGAGA
GTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAATGAATGATAGCATGGATACCTCAAA
CAAGGAAGAGAAATGAGGATCTCAGGACCTTGGTGGACACTGTGTACACCTCTGGATTCATTGTCTCTCACAGATGTGACTGTATAACTT
TCCCAGGTTCTGTTTATGGCCACATTTAATATCTTCAGCTCTTTTTGTGGATATAAAATGTGCAGATGCAATTGTTTGGGTGATTCCTAA
GCCACTTGAAATGTTAGTCATTGTTATTTATACAAGATTGAAAATCTTGTGTAAATCCTGCCATTTAAAAAGTTGTAGCAGATTGTTTCC
TCTTCCAAAGTAAAATTGCTGTGCTTTATGGATAGTAAGAATGGCCCTAGAGTGGGAGTCCTGATAACCCAGGCCTGTCTGACTACTTTG
CCTTCTTTTGTAGCATATAGGTGATGTTTGCTCTTGTTTTTATTAATTTATATGTATATTTTTTTAATTTAACATGAACACCCTTAGAAA
ATGTGTCCTATCTATCTTCCAAATGCAATTTGATTGACTGCCCATTCACCAAAATTATCCTGAACTCTTCTGCAAAAATGGATATTATTA
GAAATTAGAAAAAAATTACTAATTTTACACATTAGATTTTATTTTACTATTGGAATCTGATATACTGTGTGCTTGTTTTATAAAATTTTG
CTTTTAATTAAATAAAAGCTGGAAGCAAAGTATAACCATATGATACTATCATACTACTGAAACAGATTTCATACCTCAGAATGTAAAAGA
ACTTACTGATTATTTTCTTCATCCAACTTATGTTTTTAAATGAGGATTATTGATAGTACTCTTGGTTTTTATACCATTCAGATCACTGAA
TTTATAAAGTACCCATCTAGTACTTGAAAAAGTAAAGTGTTCTGCCAGATCTTAGGTATAGAGGACCCTAACACAGTATATCCCAAGTGC
ACTTTCTAATGTTTCTGGGTCCTGAAGAATTAAGATACAAATTAATTTTACTCCATAAACAGACTGTTAATTATAGGAGCCTTAATTTTT
TTTTCATAGAGATTTGTCTAATTGCATCTCAAAATTATTCTGCCCTCCTTAATTTGGGAAGGTTTGTGTTTTCTCTGGAATGGTACATGT
CTTCCATGTATCTTTTGAACTGGCAATTGTCTATTTATCTTTTATTTTTTTAAGTCAGTATGGTCTAACACTGGCATGTTCAAAGCCACA
TTATTTCTAGTCCAAAATTACAAGTAATCAAGGGTCATTATGGGTTAGGCATTAATGTTTCTATCTGATTTTGTGCAAAAGCTTCAAATT
AAAACAGCTGCATTAGAAAAAGAGGCGCTTCTCCCCTCCCCTACACCTAAAGGTGTATTTAAACTATCTTGTGTGATTAACTTATTTAGA
GATGCTGTAACTTAAAATAGGGGATATTTAAGGTAGCTTCAGCTAGCTTTTAGGAAAATCACTTTGTCTAACTCAGAATTATTTTTAAAA
AGAAATCTGGTCTTGTTAGAAAACAAAATTTTATTTTGTGCTCATTTAAGTTTCAAACTTACTATTTTGACAGTTATTTTGATAACAATG
ACACTAGAAAACTTGACTCCATTTCATCATTGTTTCTGCATGAATATCATACAAATCAGTTAGTTTTTAGGTCAAGGGCTTACTATTTCT
GGGTCTTTTGCTACTAAGTTCACATTAGAATTAGTGCCAGAATTTTAGGAACTTCAGAGATCGTGTATTGAGATTTCTTAAATAATGCTT
CAGATATTATTGCTTTATTGCTTTTTTGTATTGGTTAAAACTGTACATTTAAAATTGCTATGTTACTATTTTCTACAATTAATAGTTTGT
CTATTTTAAAATAAATTAGTTGTTAAGAGTCTTAATGGTCTGATGTTGTGTTCTTTGTATTAAGTACACTAATGTTCTCTTTTCTGTCTA

>30903_30903_5_FNDC3A-RB1_FNDC3A_chr13_49688867_ENST00000541916_RB1_chr13_49037867_ENST00000267163_length(amino acids)=312AA_BP=86
MIMAEHPPLLDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGPAQVPMMSPNGSVPPIYVPPGYAPQIMMC
SMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSP
LRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEAD

--------------------------------------------------------------
>30903_30903_6_FNDC3A-RB1_FNDC3A_chr13_49688867_ENST00000541916_RB1_chr13_49039134_ENST00000267163_length(transcript)=2816nt_BP=325nt
TTGACACGGCTTTGGAAACGACGTCATGTGTTAGAATTGGAGCGTTATTCAGTATATTAATGTCTTATTGATAATGGCAGAACATCCACC
ACTACTGGATACAACTCAGATCTTAAGTAGTGATATTTCTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGAACACAACAGGTTATTCT
GGTACAAGTTAACCCAGGAGAAGCATTTACAATAAGAAGAGAAGATGGACAGTTTCAGTGCATTACAGGTCCTGCTCAGGTTCCAATGAT
GTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTCCTGGATATGCCCCACAGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTA
TGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACAAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTT
GTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCT
GAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACTCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATT
CGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCC
TAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGATGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCA
GAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAATGAATGATAGCATGGATACCTCAAACAAGGAAGAGAAATG
AGGATCTCAGGACCTTGGTGGACACTGTGTACACCTCTGGATTCATTGTCTCTCACAGATGTGACTGTATAACTTTCCCAGGTTCTGTTT
ATGGCCACATTTAATATCTTCAGCTCTTTTTGTGGATATAAAATGTGCAGATGCAATTGTTTGGGTGATTCCTAAGCCACTTGAAATGTT
AGTCATTGTTATTTATACAAGATTGAAAATCTTGTGTAAATCCTGCCATTTAAAAAGTTGTAGCAGATTGTTTCCTCTTCCAAAGTAAAA
TTGCTGTGCTTTATGGATAGTAAGAATGGCCCTAGAGTGGGAGTCCTGATAACCCAGGCCTGTCTGACTACTTTGCCTTCTTTTGTAGCA
TATAGGTGATGTTTGCTCTTGTTTTTATTAATTTATATGTATATTTTTTTAATTTAACATGAACACCCTTAGAAAATGTGTCCTATCTAT
CTTCCAAATGCAATTTGATTGACTGCCCATTCACCAAAATTATCCTGAACTCTTCTGCAAAAATGGATATTATTAGAAATTAGAAAAAAA
TTACTAATTTTACACATTAGATTTTATTTTACTATTGGAATCTGATATACTGTGTGCTTGTTTTATAAAATTTTGCTTTTAATTAAATAA
AAGCTGGAAGCAAAGTATAACCATATGATACTATCATACTACTGAAACAGATTTCATACCTCAGAATGTAAAAGAACTTACTGATTATTT
TCTTCATCCAACTTATGTTTTTAAATGAGGATTATTGATAGTACTCTTGGTTTTTATACCATTCAGATCACTGAATTTATAAAGTACCCA
TCTAGTACTTGAAAAAGTAAAGTGTTCTGCCAGATCTTAGGTATAGAGGACCCTAACACAGTATATCCCAAGTGCACTTTCTAATGTTTC
TGGGTCCTGAAGAATTAAGATACAAATTAATTTTACTCCATAAACAGACTGTTAATTATAGGAGCCTTAATTTTTTTTTCATAGAGATTT
GTCTAATTGCATCTCAAAATTATTCTGCCCTCCTTAATTTGGGAAGGTTTGTGTTTTCTCTGGAATGGTACATGTCTTCCATGTATCTTT
TGAACTGGCAATTGTCTATTTATCTTTTATTTTTTTAAGTCAGTATGGTCTAACACTGGCATGTTCAAAGCCACATTATTTCTAGTCCAA
AATTACAAGTAATCAAGGGTCATTATGGGTTAGGCATTAATGTTTCTATCTGATTTTGTGCAAAAGCTTCAAATTAAAACAGCTGCATTA
GAAAAAGAGGCGCTTCTCCCCTCCCCTACACCTAAAGGTGTATTTAAACTATCTTGTGTGATTAACTTATTTAGAGATGCTGTAACTTAA
AATAGGGGATATTTAAGGTAGCTTCAGCTAGCTTTTAGGAAAATCACTTTGTCTAACTCAGAATTATTTTTAAAAAGAAATCTGGTCTTG
TTAGAAAACAAAATTTTATTTTGTGCTCATTTAAGTTTCAAACTTACTATTTTGACAGTTATTTTGATAACAATGACACTAGAAAACTTG
ACTCCATTTCATCATTGTTTCTGCATGAATATCATACAAATCAGTTAGTTTTTAGGTCAAGGGCTTACTATTTCTGGGTCTTTTGCTACT
AAGTTCACATTAGAATTAGTGCCAGAATTTTAGGAACTTCAGAGATCGTGTATTGAGATTTCTTAAATAATGCTTCAGATATTATTGCTT
TATTGCTTTTTTGTATTGGTTAAAACTGTACATTTAAAATTGCTATGTTACTATTTTCTACAATTAATAGTTTGTCTATTTTAAAATAAA
TTAGTTGTTAAGAGTCTTAATGGTCTGATGTTGTGTTCTTTGTATTAAGTACACTAATGTTCTCTTTTCTGTCTAGGAGAAGATAGATAG

>30903_30903_6_FNDC3A-RB1_FNDC3A_chr13_49688867_ENST00000541916_RB1_chr13_49039134_ENST00000267163_length(amino acids)=277AA_BP=84
MIMAEHPPLLDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGPAQVPMMSPNGSVPPIYVPPGYAPQTFKR
VLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRI
LVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTSTRTRMQKQKMNDSMD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for FNDC3A-RB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneRB1chr13:49688867chr13:49037867ENST000002671631927763_928702.0929.0LIMD1
TgeneRB1chr13:49688867chr13:49039134ENST000002671632027763_928737.0929.0LIMD1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for FNDC3A-RB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for FNDC3A-RB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0035335Retinoblastoma15CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0006142Malignant neoplasm of breast3CGI;CTD_human
TgeneC0149925Small cell carcinoma of lung3CGI;CTD_human;ORPHANET
TgeneC0678222Breast Carcinoma3CGI;CTD_human
TgeneC0751483Familial Retinoblastoma3CTD_human;ORPHANET
TgeneC1257931Mammary Neoplasms, Human3CTD_human
TgeneC1458155Mammary Neoplasms3CTD_human
TgeneC4704874Mammary Carcinoma, Human3CTD_human
TgeneC0029463Osteosarcoma2CTD_human;ORPHANET
TgeneC2239176Liver carcinoma2CTD_human
TgeneC0001624Adrenal Gland Neoplasms1CTD_human
TgeneC0007097Carcinoma1CTD_human
TgeneC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneC0007786Brain Ischemia1CTD_human
TgeneC0014518Toxic Epidermal Necrolysis1CTD_human
TgeneC0019207Hepatoma, Morris1CTD_human
TgeneC0019208Hepatoma, Novikoff1CTD_human
TgeneC0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
TgeneC0023453L2 Acute Lymphoblastic Leukemia1CTD_human
TgeneC0023904Liver Neoplasms, Experimental1CTD_human
TgeneC0024667Animal Mammary Neoplasms1CTD_human
TgeneC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneC0027627Neoplasm Metastasis1CTD_human
TgeneC0027659Neoplasms, Experimental1CTD_human
TgeneC0030297Pancreatic Neoplasm1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0036920Sezary Syndrome1CTD_human
TgeneC0038325Stevens-Johnson Syndrome1CTD_human
TgeneC0086404Experimental Hepatoma1CTD_human
TgeneC0205696Anaplastic carcinoma1CTD_human
TgeneC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneC0205698Undifferentiated carcinoma1CTD_human
TgeneC0205699Carcinomatosis1CTD_human
TgeneC0206686Adrenocortical carcinoma1CTD_human
TgeneC0238198Gastrointestinal Stromal Tumors1CTD_human
TgeneC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneC0346647Malignant neoplasm of pancreas1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC0750887Adrenal Cancer1CTD_human
TgeneC0917798Cerebral Ischemia1CTD_human
TgeneC1257925Mammary Carcinoma, Animal1CTD_human
TgeneC1274933Drug-Induced Stevens Johnson Syndrome1CTD_human
TgeneC1368275Pigmented Basal Cell Carcinoma1CTD_human
TgeneC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneC2608045Trilateral Retinoblastoma1GENOMICS_ENGLAND
TgeneC2930974Acute erythroleukemia1CTD_human
TgeneC2930975Acute erythroleukemia - M6a subtype1CTD_human
TgeneC2930976Acute myeloid leukemia FAB-M61CTD_human
TgeneC2930977Acute erythroleukemia - M6b subtype1CTD_human
TgeneC3151302Chromosome 13q14 deletion syndrome1ORPHANET
TgeneC3179349Gastrointestinal Stromal Sarcoma1CTD_human
TgeneC3658301Mycoplasma-Induced Stevens-Johnson Syndrome1CTD_human
TgeneC3658302Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum1CTD_human
TgeneC4721806Carcinoma, Basal Cell1CTD_human